ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of memory T cell differentiation (GO:0043380)	5.38461276
2	rRNA methylation (GO:0031167)	5.12863255
3	dopamine transport (GO:0015872)	5.04492572
4	rRNA modification (GO:0000154)	4.69847909
5	positive regulation of alpha-beta T cell proliferation (GO:0046641)	4.22801487
6	synapsis (GO:0007129)	4.08721386
7	necroptotic process (GO:0070266)	4.07338582
8	positive regulation of interleukin-17 production (GO:0032740)	3.98965754
9	regulation of RIG-I signaling pathway (GO:0039535)	3.74894851
10	regulation of B cell receptor signaling pathway (GO:0050855)	3.73116877
11	centriole replication (GO:0007099)	3.60050606
12	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	3.56281172
13	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.54912879
14	positive regulation of granulocyte differentiation (GO:0030854)	3.54761677
15	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	3.44929117
16	negative regulation of T-helper cell differentiation (GO:0045623)	3.44929117
17	regulation of alpha-beta T cell proliferation (GO:0046640)	3.43806632
18	DNA deamination (GO:0045006)	3.42761188
19	regulation of regulatory T cell differentiation (GO:0045589)	3.34405056
20	replication fork processing (GO:0031297)	3.33045684
21	organelle membrane fusion (GO:0090174)	3.32742050
22	programmed necrotic cell death (GO:0097300)	3.32159071
23	RNA methylation (GO:0001510)	3.27803733
24	reciprocal meiotic recombination (GO:0007131)	3.23485175
25	reciprocal DNA recombination (GO:0035825)	3.23485175
26	NIK/NF-kappaB signaling (GO:0038061)	3.21620173
27	regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)	3.21050090
28	negative regulation of phosphoprotein phosphatase activity (GO:0032515)	3.19666560
29	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	3.17751834
30	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	3.17715310
31	necrotic cell death (GO:0070265)	3.16129078
32	neutrophil activation involved in immune response (GO:0002283)	3.14014680
33	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.08594977
34	inositol phosphate catabolic process (GO:0071545)	2.98341822
35	regulation of female gonad development (GO:2000194)	2.97237837
36	sensory perception of smell (GO:0007608)	2.96665818
37	cellular ketone body metabolic process (GO:0046950)	2.96584242
38	lymph node development (GO:0048535)	2.95494189
39	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.93597876
40	protein localization to Golgi apparatus (GO:0034067)	2.93116218
41	double-strand break repair via homologous recombination (GO:0000724)	2.91913919
42	recombinational repair (GO:0000725)	2.91620498
43	proteasome assembly (GO:0043248)	2.91186273
44	negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)	2.86736274
45	regulation of interleukin-17 production (GO:0032660)	2.86395417
46	catecholamine transport (GO:0051937)	2.85001523
47	rRNA catabolic process (GO:0016075)	2.83245687
48	ketone body metabolic process (GO:1902224)	2.81504731
49	inositol phosphate dephosphorylation (GO:0046855)	2.81179675
50	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.81179675
51	regulation of establishment of cell polarity (GO:2000114)	2.80806330
52	intra-S DNA damage checkpoint (GO:0031573)	2.79529026
53	DNA double-strand break processing (GO:0000729)	2.78596556
54	regulation of meiosis I (GO:0060631)	2.78313364
55	mitochondrial RNA metabolic process (GO:0000959)	2.77708194
56	regulation of protein polyubiquitination (GO:1902914)	2.75816407
57	regulation of DNA endoreduplication (GO:0032875)	2.72924309
58	positive regulation of gamma-delta T cell activation (GO:0046645)	2.68712624
59	monoubiquitinated protein deubiquitination (GO:0035520)	2.67997938
60	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.67710175
61	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.67710175
62	AMP metabolic process (GO:0046033)	2.66732489
63	phosphorelay signal transduction system (GO:0000160)	2.64834303
64	regulation of DNA recombination (GO:0000018)	2.63348186
65	pyrimidine dimer repair (GO:0006290)	2.63249896
66	dopamine biosynthetic process (GO:0042416)	2.61311380
67	mast cell activation (GO:0045576)	2.58298388
68	prenylation (GO:0097354)	2.55691193
69	protein prenylation (GO:0018342)	2.55691193
70	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.54867014
71	monoamine transport (GO:0015844)	2.54188757
72	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	2.53749366
73	regulation of necroptotic process (GO:0060544)	2.53308791
74	piRNA metabolic process (GO:0034587)	2.50048718
75	hepatocyte apoptotic process (GO:0097284)	2.48894314
76	regulation of gamma-delta T cell differentiation (GO:0045586)	2.48042376
77	polyol catabolic process (GO:0046174)	2.47925932
78	protein K6-linked ubiquitination (GO:0085020)	2.47483961
79	ADP metabolic process (GO:0046031)	2.47409238
80	protein K11-linked deubiquitination (GO:0035871)	2.46586021
81	protoporphyrinogen IX metabolic process (GO:0046501)	2.45089106
82	histone mRNA catabolic process (GO:0071044)	2.43883875
83	response to pheromone (GO:0019236)	2.43823889
84	T cell proliferation (GO:0042098)	2.42795346
85	positive regulation of glycoprotein biosynthetic process (GO:0010560)	2.42491413
86	regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)	2.40739338
87	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.39520197
88	autophagic vacuole fusion (GO:0000046)	2.38937715
89	regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)	2.38687804
90	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO	2.38687804
91	regulation of establishment or maintenance of cell polarity (GO:0032878)	2.38295555
92	regulation of catecholamine metabolic process (GO:0042069)	2.38261194
93	regulation of dopamine metabolic process (GO:0042053)	2.38261194
94	negative regulation of DNA recombination (GO:0045910)	2.35983268
95	poly(A)+ mRNA export from nucleus (GO:0016973)	2.35919938
96	base-excision repair, AP site formation (GO:0006285)	2.35830904
97	mannosylation (GO:0097502)	2.35161294
98	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.34905010
99	positive regulation of mRNA catabolic process (GO:0061014)	2.32318112
100	positive regulation of natural killer cell activation (GO:0032816)	2.31567714

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.60594866
2	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.20575848
3	E2F7_22180533_ChIP-Seq_HELA_Human	2.86239099
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.80317459
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.77641949
6	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.70251532
7	VDR_22108803_ChIP-Seq_LS180_Human	2.65479104
8	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.60513941
9	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.59266787
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.40868485
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.38258503
12	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.33555636
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.32514121
14	ELK1_19687146_ChIP-ChIP_HELA_Human	2.23642132
15	ZNF274_21170338_ChIP-Seq_K562_Hela	2.22518598
16	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.17512620
17	VDR_23849224_ChIP-Seq_CD4+_Human	2.16139265
18	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.14593708
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.94105011
20	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.92366814
21	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.85702710
22	FOXP3_21729870_ChIP-Seq_TREG_Human	1.80080159
23	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.72306201
24	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.72006051
25	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.70798616
26	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.70605094
27	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.70361207
28	GATA1_22025678_ChIP-Seq_K562_Human	1.67033172
29	MYB_26560356_Chip-Seq_TH2_Human	1.66662907
30	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.65959259
31	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.64317118
32	ER_23166858_ChIP-Seq_MCF-7_Human	1.63825283
33	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.63060472
34	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.61490920
35	SCL_19346495_ChIP-Seq_HPC-7_Human	1.60336404
36	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.59005220
37	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.57215303
38	RUNX_20019798_ChIP-Seq_JUKART_Human	1.53217432
39	FUS_26573619_Chip-Seq_HEK293_Human	1.51746097
40	GBX2_23144817_ChIP-Seq_PC3_Human	1.50147169
41	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.49624535
42	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.48842596
43	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.48838908
44	EWS_26573619_Chip-Seq_HEK293_Human	1.47778829
45	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.44735309
46	GATA3_26560356_Chip-Seq_TH2_Human	1.43405409
47	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.36246623
48	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.31263065
49	TAF15_26573619_Chip-Seq_HEK293_Human	1.29406378
50	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.29405750
51	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.29113592
52	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	1.28157755
53	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.27171826
54	TP53_22573176_ChIP-Seq_HFKS_Human	1.26048310
55	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.25919374
56	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.24301285
57	GATA3_27048872_Chip-Seq_THYMUS_Human	1.23650524
58	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.23406840
59	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.22540764
60	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.22485920
61	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.22485920
62	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.22349602
63	IRF1_19129219_ChIP-ChIP_H3396_Human	1.21900016
64	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.19494524
65	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.18890519
66	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.17627629
67	MYB_26560356_Chip-Seq_TH1_Human	1.14939349
68	NANOG_19829295_ChIP-Seq_ESCs_Human	1.09638112
69	SOX2_19829295_ChIP-Seq_ESCs_Human	1.09638112
70	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.09492504
71	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.08054120
72	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.07402453
73	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.06266549
74	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.05773830
75	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	1.03313647
76	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.02102071
77	IRF8_27001747_Chip-Seq_BMDM_Mouse	1.01597710
78	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.01346097
79	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.01154984
80	STAT3_23295773_ChIP-Seq_U87_Human	0.97626979
81	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.97048770
82	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	0.96926284
83	PHF8_20622853_ChIP-Seq_HELA_Human	0.96176417
84	P300_18555785_Chip-Seq_ESCs_Mouse	0.95653270
85	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.95480577
86	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.95441246
87	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.95108671
88	RBPJ_21746931_ChIP-Seq_IB4_Human	0.94978295
89	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.94627250
90	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.94603937
91	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.93936661
92	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.93165036
93	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.92974206
94	CDX2_22108803_ChIP-Seq_LS180_Human	0.92869268
95	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.92834198
96	ETV1_20927104_ChIP-Seq_GIST48_Human	0.91879245
97	GATA3_26560356_Chip-Seq_TH1_Human	0.91826056
98	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.91712965
99	NMYC_18555785_Chip-Seq_ESCs_Mouse	0.91177386
100	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.90998686

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	3.99047624
2	MP0008877_abnormal_DNA_methylation	3.17776027
3	MP0003787_abnormal_imprinting	3.07131242
4	MP0008057_abnormal_DNA_replication	2.81188862
5	MP0008058_abnormal_DNA_repair	2.69350344
6	MP0002396_abnormal_hematopoietic_system	2.60161578
7	MP0008995_early_reproductive_senescence	2.49630191
8	MP0005379_endocrine/exocrine_gland_phen	2.44475401
9	MP0003786_premature_aging	2.42522301
10	MP0003806_abnormal_nucleotide_metabolis	2.42077523
11	MP0010094_abnormal_chromosome_stability	2.40977335
12	MP0002163_abnormal_gland_morphology	2.37075893
13	MP0003763_abnormal_thymus_physiology	2.20951955
14	MP0000372_irregular_coat_pigmentation	2.02567580
15	MP0005075_abnormal_melanosome_morpholog	1.98476748
16	MP0009785_altered_susceptibility_to	1.98028119
17	MP0000685_abnormal_immune_system	1.92904268
18	MP0001835_abnormal_antigen_presentation	1.92627357
19	MP0004147_increased_porphyrin_level	1.75460895
20	MP0003646_muscle_fatigue	1.71194714
21	MP0003724_increased_susceptibility_to	1.67814869
22	MP0000569_abnormal_digit_pigmentation	1.67195444
23	MP0008872_abnormal_physiological_respon	1.64255206
24	MP0003183_abnormal_peptide_metabolism	1.61682281
25	MP0002148_abnormal_hypersensitivity_rea	1.59789197
26	MP0003656_abnormal_erythrocyte_physiolo	1.58619250
27	MP0003718_maternal_effect	1.54932104
28	MP0001800_abnormal_humoral_immune	1.52310891
29	MP0006036_abnormal_mitochondrial_physio	1.51659468
30	MP0000015_abnormal_ear_pigmentation	1.48459222
31	MP0006054_spinal_hemorrhage	1.47932029
32	MP0009333_abnormal_splenocyte_physiolog	1.47879560
33	MP0005397_hematopoietic_system_phenotyp	1.47388412
34	MP0001545_abnormal_hematopoietic_system	1.47388412
35	MP0001764_abnormal_homeostasis	1.43491197
36	MP0000689_abnormal_spleen_morphology	1.43460482
37	MP0001501_abnormal_sleep_pattern	1.41300705
38	MP0002398_abnormal_bone_marrow	1.39218798
39	MP0003943_abnormal_hepatobiliary_system	1.38230693
40	MP0005671_abnormal_response_to	1.36354730
41	MP0005000_abnormal_immune_tolerance	1.34546637
42	MP0002722_abnormal_immune_system	1.31830529
43	MP0002723_abnormal_immune_serum	1.31516979
44	MP0000703_abnormal_thymus_morphology	1.30944687
45	MP0009697_abnormal_copulation	1.29785869
46	MP0002876_abnormal_thyroid_physiology	1.28127212
47	MP0002638_abnormal_pupillary_reflex	1.23434082
48	MP0000716_abnormal_immune_system	1.19108714
49	MP0002420_abnormal_adaptive_immunity	1.16794473
50	MP0002132_abnormal_respiratory_system	1.16551332
51	MP0001819_abnormal_immune_cell	1.16227182
52	MP0001905_abnormal_dopamine_level	1.15925951
53	MP0002019_abnormal_tumor_incidence	1.14699797
54	MP0002452_abnormal_antigen_presenting	1.10822702
55	MP0002429_abnormal_blood_cell	1.10738501
56	MP0001853_heart_inflammation	1.10539108
57	MP0009278_abnormal_bone_marrow	1.10259340
58	MP0008775_abnormal_heart_ventricle	1.06057431
59	MP0005464_abnormal_platelet_physiology	1.03071819
60	MP0001873_stomach_inflammation	1.02994800
61	MP0002166_altered_tumor_susceptibility	1.02385095
62	MP0005387_immune_system_phenotype	1.01957115
63	MP0001790_abnormal_immune_system	1.01957115
64	MP0003866_abnormal_defecation	1.00734790
65	MP0001986_abnormal_taste_sensitivity	0.99551491
66	MP0009764_decreased_sensitivity_to	0.99211077
67	MP0001929_abnormal_gametogenesis	0.98590037
68	MP0001191_abnormal_skin_condition	0.97991179
69	MP0005410_abnormal_fertilization	0.95058648
70	MP0005084_abnormal_gallbladder_morpholo	0.95032676
71	MP0005310_abnormal_salivary_gland	0.94543715
72	MP0005332_abnormal_amino_acid	0.93992708
73	MP0005174_abnormal_tail_pigmentation	0.91703048
74	MP0008875_abnormal_xenobiotic_pharmacok	0.89338102
75	MP0005083_abnormal_biliary_tract	0.89242666
76	MP0005025_abnormal_response_to	0.88994156
77	MP0002405_respiratory_system_inflammati	0.88564570
78	MP0010155_abnormal_intestine_physiology	0.88352066
79	MP0002095_abnormal_skin_pigmentation	0.88244337
80	MP0001845_abnormal_inflammatory_respons	0.87149440
81	MP0004883_abnormal_blood_vessel	0.85002691
82	MP0001177_atelectasis	0.84149200
83	MP0004957_abnormal_blastocyst_morpholog	0.83518875
84	MP0005266_abnormal_metabolism	0.83183143
85	MP0005376_homeostasis/metabolism_phenot	0.82350808
86	MP0003123_paternal_imprinting	0.80995800
87	MP0006082_CNS_inflammation	0.80970536
88	MP0006072_abnormal_retinal_apoptosis	0.80156025
89	MP0003121_genomic_imprinting	0.80124178
90	MP0004484_altered_response_of	0.79122574
91	MP0002419_abnormal_innate_immunity	0.78649406
92	MP0001119_abnormal_female_reproductive	0.76694210
93	MP0003436_decreased_susceptibility_to	0.76535244
94	MP0004808_abnormal_hematopoietic_stem	0.76482597
95	MP0002006_tumorigenesis	0.74431383
96	MP0005551_abnormal_eye_electrophysiolog	0.73340710
97	MP0010386_abnormal_urinary_bladder	0.72781463
98	MP0003252_abnormal_bile_duct	0.72429936
99	MP0000427_abnormal_hair_cycle	0.70995897
100	MP0005253_abnormal_eye_physiology	0.69809999

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chromsome breakage (HP:0040012)	3.76774239
2	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.49611747
3	Abnormality of DNA repair (HP:0003254)	3.32634250
4	Autoimmune hemolytic anemia (HP:0001890)	3.29752003
5	Metaphyseal dysplasia (HP:0100255)	3.14211325
6	Severe visual impairment (HP:0001141)	3.04614141
7	Abnormality of T cell number (HP:0011839)	2.93607299
8	Increased CSF lactate (HP:0002490)	2.83884236
9	Abnormality of chromosome stability (HP:0003220)	2.82567500
10	IgM deficiency (HP:0002850)	2.82553743
11	Duplicated collecting system (HP:0000081)	2.69938863
12	Neonatal respiratory distress (HP:0002643)	2.69238639
13	Attenuation of retinal blood vessels (HP:0007843)	2.64624655
14	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.60489571
15	T lymphocytopenia (HP:0005403)	2.54329243
16	Progressive microcephaly (HP:0000253)	2.53343779
17	Abnormality of the renal collecting system (HP:0004742)	2.52968186
18	IgG deficiency (HP:0004315)	2.51637920
19	Clubbing of toes (HP:0100760)	2.49611919
20	Abnormality of glycolysis (HP:0004366)	2.47294331
21	Increased serum pyruvate (HP:0003542)	2.46568022
22	Abnormality of macular pigmentation (HP:0008002)	2.43281762
23	Abnormality of the preputium (HP:0100587)	2.43137002
24	Hypoplastic iliac wings (HP:0002866)	2.42726284
25	Gonadotropin excess (HP:0000837)	2.40579727
26	Enlarged epiphyses (HP:0010580)	2.38498514
27	Brushfield spots (HP:0001088)	2.36961260
28	Abnormality of the fovea (HP:0000493)	2.35941291
29	Stomach cancer (HP:0012126)	2.34560959
30	Abnormal rod and cone electroretinograms (HP:0008323)	2.31469515
31	Increased serum lactate (HP:0002151)	2.30345030
32	Increased hepatocellular lipid droplets (HP:0006565)	2.29259409
33	Acute encephalopathy (HP:0006846)	2.26416802
34	Myelodysplasia (HP:0002863)	2.25345643
35	Hypokinesia (HP:0002375)	2.24470371
36	Renal cortical cysts (HP:0000803)	2.24335899
37	Limb dystonia (HP:0002451)	2.22714505
38	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.21320531
39	Hypoplasia of the fovea (HP:0007750)	2.21320531
40	Acute myeloid leukemia (HP:0004808)	2.21256762
41	Abnormality of the ileum (HP:0001549)	2.20552607
42	Lipid accumulation in hepatocytes (HP:0006561)	2.19058709
43	Meckel diverticulum (HP:0002245)	2.18954052
44	Acute necrotizing encephalopathy (HP:0006965)	2.18168298
45	Neoplasm of the adrenal gland (HP:0100631)	2.18080220
46	Small intestinal stenosis (HP:0012848)	2.16853441
47	Duodenal stenosis (HP:0100867)	2.16853441
48	Abnormality of the pons (HP:0007361)	2.16444398
49	Abnormality of B cell number (HP:0010975)	2.15126819
50	Hypoplasia of the pons (HP:0012110)	2.12439639
51	Constricted visual fields (HP:0001133)	2.12329765
52	Abnormality of T cells (HP:0002843)	2.12216010
53	Limb hypertonia (HP:0002509)	2.11601892
54	Mitochondrial inheritance (HP:0001427)	2.07876215
55	Stomatitis (HP:0010280)	2.07574009
56	Sloping forehead (HP:0000340)	2.07299547
57	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.07081689
58	Progressive macrocephaly (HP:0004481)	2.05037742
59	Embryonal renal neoplasm (HP:0011794)	2.04023358
60	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.02609449
61	Type II lissencephaly (HP:0007260)	2.01634857
62	Hepatic necrosis (HP:0002605)	2.00616132
63	Abnormality of T cell physiology (HP:0011840)	2.00266799
64	Abnormality of pyrimidine metabolism (HP:0004353)	1.93788409
65	Nephroblastoma (Wilms tumor) (HP:0002667)	1.93191151
66	Birth length less than 3rd percentile (HP:0003561)	1.90931578
67	Gaze-evoked nystagmus (HP:0000640)	1.90639772
68	Menstrual irregularities (HP:0000858)	1.90115925
69	Nephronophthisis (HP:0000090)	1.88618821
70	Congenital stationary night blindness (HP:0007642)	1.88312900
71	Abnormal mitochondria in muscle tissue (HP:0008316)	1.85690430
72	Increased IgM level (HP:0003496)	1.84043899
73	Carpal bone hypoplasia (HP:0001498)	1.81711989
74	Abnormal spermatogenesis (HP:0008669)	1.81201847
75	Medial flaring of the eyebrow (HP:0010747)	1.79407745
76	Neoplasm of the adrenal cortex (HP:0100641)	1.79321010
77	Paralysis (HP:0003470)	1.79173840
78	Disproportionate short-trunk short stature (HP:0003521)	1.77993772
79	Optic disc pallor (HP:0000543)	1.74652243
80	Elevated erythrocyte sedimentation rate (HP:0003565)	1.72602682
81	Abnormality of the duodenum (HP:0002246)	1.72107138
82	Gonadal dysgenesis (HP:0000133)	1.72080716
83	Diastasis recti (HP:0001540)	1.72069146
84	Acute lymphatic leukemia (HP:0006721)	1.72020397
85	Albinism (HP:0001022)	1.71505146
86	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.71457527
87	Abnormality of alanine metabolism (HP:0010916)	1.71457527
88	Hyperalaninemia (HP:0003348)	1.71457527
89	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	1.70686088
90	Intellectual disability, profound (HP:0002187)	1.70637766
91	Lactic acidosis (HP:0003128)	1.70613176
92	Molar tooth sign on MRI (HP:0002419)	1.69167790
93	Abnormality of midbrain morphology (HP:0002418)	1.69167790
94	Patchy hypopigmentation of hair (HP:0011365)	1.68753638
95	Respiratory difficulties (HP:0002880)	1.68156156
96	Ovarian neoplasm (HP:0100615)	1.67550700
97	Alveolar cell carcinoma (HP:0006519)	1.67482160
98	Central scotoma (HP:0000603)	1.67327100
99	Aplasia/Hypoplasia of the macula (HP:0008059)	1.67278902
100	Abnormal glycosylation (HP:0012345)	1.66861691

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NUAK1	4.40476936
2	PDK2	3.33894456
3	RIPK4	3.15607542
4	MST4	3.07734911
5	FRK	3.06993273
6	LATS1	2.76665978
7	EIF2AK1	2.36023645
8	PLK4	2.30517219
9	EIF2AK3	2.23123045
10	ZAK	2.20713192
11	TXK	2.19839645
12	CDC7	2.17499318
13	PINK1	2.11120870
14	BUB1	2.02764683
15	TEC	2.01319538
16	ACVR1B	1.91026864
17	TAOK3	1.85340882
18	BMPR1B	1.62639519
19	BRSK2	1.61391312
20	BMPR2	1.60056831
21	MAP3K2	1.50647746
22	PLK2	1.45279850
23	ITK	1.24676822
24	FLT3	1.23437308
25	PIK3CG	1.23103017
26	PLK3	1.20189850
27	VRK1	1.17447228
28	ADRBK2	1.17338754
29	BCR	1.14670199
30	TTK	1.11487567
31	WNK4	1.04301189
32	AKT3	1.01888758
33	CAMKK2	0.99397110
34	MAP4K1	0.94753777
35	MAP2K3	0.94715577
36	MAP2K6	0.93915851
37	IKBKB	0.90958617
38	CSNK1G3	0.90232223
39	MAP4K2	0.87338127
40	WEE1	0.86043618
41	CSNK1G2	0.82249466
42	KIT	0.80958349
43	TSSK6	0.80905877
44	TRIM28	0.79224495
45	TNIK	0.75444715
46	FES	0.75295282
47	MAPK11	0.73956856
48	MAPK13	0.73384505
49	GRK6	0.73251252
50	PBK	0.71251800
51	PRKCQ	0.70705010
52	CSNK1G1	0.70653885
53	CDK3	0.69065327
54	ATR	0.68810297
55	TRPM7	0.67901026
56	EIF2AK2	0.67550016
57	VRK2	0.66858671
58	WNK1	0.66024276
59	PLK1	0.65193796
60	SYK	0.65026644
61	BTK	0.64852140
62	MAPKAPK5	0.63750310
63	OXSR1	0.60824897
64	PTK2B	0.60756220
65	JAK1	0.60247669
66	GRK5	0.59857610
67	MELK	0.59640849
68	LCK	0.59272252
69	IRAK1	0.58368454
70	CHEK2	0.58307553
71	NLK	0.57539392
72	TNK2	0.57185716
73	ERBB3	0.57016481
74	DYRK1A	0.56039494
75	GRK1	0.55311757
76	ADRBK1	0.55066187
77	PHKG1	0.55000293
78	PHKG2	0.55000293
79	PAK3	0.53991381
80	SRPK1	0.50733580
81	STK3	0.50643873
82	ATM	0.50095262
83	HCK	0.46729676
84	YES1	0.45721950
85	MKNK2	0.44736336
86	TAF1	0.43930185
87	MAP3K12	0.43678373
88	STK4	0.42480212
89	CSF1R	0.42013873
90	NEK1	0.40101713
91	ERBB4	0.39974935
92	BRSK1	0.39934181
93	PKN1	0.39387695
94	PASK	0.39194970
95	MAP3K14	0.36357448
96	CSNK1D	0.34816382
97	CHEK1	0.34789716
98	MAP3K5	0.33747082
99	HIPK2	0.32974158
100	PIK3CA	0.32234368

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Homologous recombination_Homo sapiens_hsa03440	4.45523309
2	Fanconi anemia pathway_Homo sapiens_hsa03460	2.97791934
3	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.77458100
4	Non-homologous end-joining_Homo sapiens_hsa03450	2.45573002
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.38242768
6	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.31153354
7	Butanoate metabolism_Homo sapiens_hsa00650	2.22474319
8	RNA degradation_Homo sapiens_hsa03018	2.18870471
9	Selenocompound metabolism_Homo sapiens_hsa00450	2.15835411
10	Proteasome_Homo sapiens_hsa03050	2.12960123
11	One carbon pool by folate_Homo sapiens_hsa00670	2.11091085
12	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	2.09663516
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.99243056
14	Mismatch repair_Homo sapiens_hsa03430	1.91825560
15	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.89579538
16	Nitrogen metabolism_Homo sapiens_hsa00910	1.76559894
17	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.70888918
18	Basal transcription factors_Homo sapiens_hsa03022	1.56811598
19	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.50051488
20	RNA polymerase_Homo sapiens_hsa03020	1.49700190
21	Olfactory transduction_Homo sapiens_hsa04740	1.45811744
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.40934078
23	Primary immunodeficiency_Homo sapiens_hsa05340	1.39229718
24	Steroid biosynthesis_Homo sapiens_hsa00100	1.39106101
25	DNA replication_Homo sapiens_hsa03030	1.38494548
26	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.37343295
27	Base excision repair_Homo sapiens_hsa03410	1.34279303
28	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.28735404
29	Propanoate metabolism_Homo sapiens_hsa00640	1.22652005
30	Asthma_Homo sapiens_hsa05310	1.22110608
31	Pyrimidine metabolism_Homo sapiens_hsa00240	1.22012180
32	Sulfur metabolism_Homo sapiens_hsa00920	1.18837562
33	Parkinsons disease_Homo sapiens_hsa05012	1.15939650
34	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.11344963
35	Jak-STAT signaling pathway_Homo sapiens_hsa04630	1.10599072
36	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.09420047
37	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.09014990
38	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.07629645
39	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.06510897
40	Fatty acid elongation_Homo sapiens_hsa00062	1.03422720
41	Measles_Homo sapiens_hsa05162	1.00103150
42	Circadian rhythm_Homo sapiens_hsa04710	0.99672204
43	Oxidative phosphorylation_Homo sapiens_hsa00190	0.98811842
44	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.97927140
45	Purine metabolism_Homo sapiens_hsa00230	0.95352249
46	Amphetamine addiction_Homo sapiens_hsa05031	0.93843102
47	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.93466096
48	RNA transport_Homo sapiens_hsa03013	0.93380649
49	Collecting duct acid secretion_Homo sapiens_hsa04966	0.93136429
50	Protein export_Homo sapiens_hsa03060	0.93059704
51	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.89935252
52	TNF signaling pathway_Homo sapiens_hsa04668	0.89149929
53	Peroxisome_Homo sapiens_hsa04146	0.88285106
54	Taste transduction_Homo sapiens_hsa04742	0.84028499
55	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.80351303
56	p53 signaling pathway_Homo sapiens_hsa04115	0.79725929
57	Legionellosis_Homo sapiens_hsa05134	0.79359234
58	Nucleotide excision repair_Homo sapiens_hsa03420	0.78280146
59	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.77141314
60	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.75228288
61	Sphingolipid metabolism_Homo sapiens_hsa00600	0.73214641
62	Cell cycle_Homo sapiens_hsa04110	0.72526920
63	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.71472013
64	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.69058079
65	Pyruvate metabolism_Homo sapiens_hsa00620	0.66030360
66	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.64714667
67	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.64119686
68	Oocyte meiosis_Homo sapiens_hsa04114	0.63204639
69	Fatty acid degradation_Homo sapiens_hsa00071	0.61758890
70	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.61487950
71	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.60629273
72	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.59557850
73	Ether lipid metabolism_Homo sapiens_hsa00565	0.58723836
74	Spliceosome_Homo sapiens_hsa03040	0.57846577
75	Linoleic acid metabolism_Homo sapiens_hsa00591	0.55101728
76	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.54522475
77	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.53693574
78	Metabolic pathways_Homo sapiens_hsa01100	0.52432979
79	Regulation of autophagy_Homo sapiens_hsa04140	0.52087850
80	Sulfur relay system_Homo sapiens_hsa04122	0.51929705
81	Cocaine addiction_Homo sapiens_hsa05030	0.50053622
82	African trypanosomiasis_Homo sapiens_hsa05143	0.48883706
83	mRNA surveillance pathway_Homo sapiens_hsa03015	0.48359705
84	Fatty acid metabolism_Homo sapiens_hsa01212	0.45565942
85	Type I diabetes mellitus_Homo sapiens_hsa04940	0.43460731
86	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.43244717
87	Glycerolipid metabolism_Homo sapiens_hsa00561	0.42235458
88	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.41086066
89	Huntingtons disease_Homo sapiens_hsa05016	0.38932449
90	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.38930237
91	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.38748850
92	Rheumatoid arthritis_Homo sapiens_hsa05323	0.38332049
93	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.37727502
94	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.35921688
95	Tryptophan metabolism_Homo sapiens_hsa00380	0.35650721
96	Alzheimers disease_Homo sapiens_hsa05010	0.35252110
97	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.31970667
98	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.30537483
99	Chemokine signaling pathway_Homo sapiens_hsa04062	0.28146531
100	Herpes simplex infection_Homo sapiens_hsa05168	0.27358049

MRPL53P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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