MRPL54

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.76263921
2DNA deamination (GO:0045006)6.58588011
3viral transcription (GO:0019083)5.67150862
4translational termination (GO:0006415)5.44489089
5ribosomal small subunit biogenesis (GO:0042274)5.41777712
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.13257089
7maturation of SSU-rRNA (GO:0030490)5.00706123
8chaperone-mediated protein transport (GO:0072321)4.99311535
9cotranslational protein targeting to membrane (GO:0006613)4.98580945
10protein targeting to ER (GO:0045047)4.98379888
11translational elongation (GO:0006414)4.89671587
12protein localization to endoplasmic reticulum (GO:0070972)4.72848495
13establishment of protein localization to endoplasmic reticulum (GO:0072599)4.70216366
14ribosomal large subunit biogenesis (GO:0042273)4.59020546
15establishment of protein localization to mitochondrial membrane (GO:0090151)4.58967280
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.40652447
17viral life cycle (GO:0019058)4.33685997
18translational initiation (GO:0006413)4.33631533
19cellular protein complex disassembly (GO:0043624)4.30348584
20proteasome assembly (GO:0043248)4.29961072
21energy coupled proton transport, down electrochemical gradient (GO:0015985)4.16534493
22ATP synthesis coupled proton transport (GO:0015986)4.16534493
23nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.15299678
24telomere maintenance via semi-conservative replication (GO:0032201)4.14191220
25translation (GO:0006412)4.11052502
26deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.96936111
27negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.90651064
28DNA strand elongation involved in DNA replication (GO:0006271)3.89479094
29pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.82774645
30ribonucleoprotein complex biogenesis (GO:0022613)3.80504945
31protein complex disassembly (GO:0043241)3.73245080
32DNA strand elongation (GO:0022616)3.68717188
33telomere maintenance via recombination (GO:0000722)3.67674964
34formation of translation preinitiation complex (GO:0001731)3.66263022
35mitochondrial respiratory chain complex I assembly (GO:0032981)3.64706451
36mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.64706451
37positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.60129008
38purine deoxyribonucleotide catabolic process (GO:0009155)3.59608474
39deoxyribonucleotide catabolic process (GO:0009264)3.57969990
40macromolecular complex disassembly (GO:0032984)3.57420312
41deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.57113054
42regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.56720879
43negative regulation of ligase activity (GO:0051352)3.56494452
44negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.56494452
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.53886226
46cytochrome complex assembly (GO:0017004)3.52136516
47regulation of mitochondrial translation (GO:0070129)3.47932611
48DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.47824405
49deoxyribose phosphate catabolic process (GO:0046386)3.45944442
50anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.43997569
51GDP-mannose metabolic process (GO:0019673)3.42905652
52intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.40271871
53signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.40271871
54oxidative phosphorylation (GO:0006119)3.39864039
55antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.39845786
56signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.39007709
57signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.39007709
58signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.39007709
59regulation of cellular amino acid metabolic process (GO:0006521)3.36844440
60termination of RNA polymerase III transcription (GO:0006386)3.36216605
61transcription elongation from RNA polymerase III promoter (GO:0006385)3.36216605
62protein localization to mitochondrion (GO:0070585)3.35492863
63pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.34226980
64rRNA processing (GO:0006364)3.33541854
65cellular component biogenesis (GO:0044085)3.33254422
66mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.32471549
67spliceosomal snRNP assembly (GO:0000387)3.31715513
68signal transduction involved in DNA damage checkpoint (GO:0072422)3.30144145
69signal transduction involved in DNA integrity checkpoint (GO:0072401)3.30144145
70respiratory chain complex IV assembly (GO:0008535)3.28340157
71signal transduction involved in cell cycle checkpoint (GO:0072395)3.26687219
72respiratory electron transport chain (GO:0022904)3.25156830
73GTP biosynthetic process (GO:0006183)3.25039269
74mitotic recombination (GO:0006312)3.23590132
75base-excision repair, AP site formation (GO:0006285)3.23342623
76protein targeting to membrane (GO:0006612)3.22382501
77rRNA metabolic process (GO:0016072)3.21325279
78negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.20607382
79protein maturation by protein folding (GO:0022417)3.19971711
80electron transport chain (GO:0022900)3.18327455
81purine nucleotide salvage (GO:0032261)3.17819298
82nuclear-transcribed mRNA catabolic process (GO:0000956)3.17616329
83transcription-coupled nucleotide-excision repair (GO:0006283)3.15011703
84pyrimidine nucleotide catabolic process (GO:0006244)3.12061314
85pseudouridine synthesis (GO:0001522)3.11773882
86positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.10576911
872-deoxyribonucleotide metabolic process (GO:0009394)3.10316865
88telomere maintenance via telomere lengthening (GO:0010833)3.09871352
89negative regulation of B cell apoptotic process (GO:0002903)3.09797402
90exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.09108660
91nucleobase-containing small molecule interconversion (GO:0015949)3.08652367
92nucleotide-excision repair, DNA gap filling (GO:0006297)3.08605040
93nucleotide salvage (GO:0043173)3.08154988
94protein neddylation (GO:0045116)3.07994355
95rRNA modification (GO:0000154)3.07160528
96mRNA catabolic process (GO:0006402)3.00143007
97chromatin remodeling at centromere (GO:0031055)2.99552715
98CENP-A containing nucleosome assembly (GO:0034080)2.99393481
99deoxyribose phosphate metabolic process (GO:0019692)2.99143873
100positive regulation of ligase activity (GO:0051351)2.98319707
101nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.97664389
1027-methylguanosine mRNA capping (GO:0006370)2.96896418
103protein targeting to mitochondrion (GO:0006626)2.96661481
104ribosome biogenesis (GO:0042254)2.94720405
105purine nucleobase biosynthetic process (GO:0009113)2.94342665
106peptidyl-histidine modification (GO:0018202)2.93737548
107UTP biosynthetic process (GO:0006228)2.92452394
108mitochondrial transport (GO:0006839)2.91733193
109purine deoxyribonucleotide metabolic process (GO:0009151)2.90889897
110metallo-sulfur cluster assembly (GO:0031163)2.90808706
111iron-sulfur cluster assembly (GO:0016226)2.90808706
112RNA catabolic process (GO:0006401)2.90653416
113purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.90554142
114RNA capping (GO:0036260)2.90356082
1157-methylguanosine RNA capping (GO:0009452)2.90356082
116protein complex biogenesis (GO:0070271)2.89770238
117establishment of protein localization to mitochondrion (GO:0072655)2.89564976
118inner mitochondrial membrane organization (GO:0007007)2.88488863
119DNA replication initiation (GO:0006270)2.87960760
120purine nucleoside triphosphate biosynthetic process (GO:0009145)2.86396538
121RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.85269843
122tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.85269843
123purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.85016200
124viral mRNA export from host cell nucleus (GO:0046784)2.84536564
1252-deoxyribonucleotide biosynthetic process (GO:0009265)2.84177006
126deoxyribose phosphate biosynthetic process (GO:0046385)2.84177006
127nucleoside salvage (GO:0043174)2.82737151
128nucleobase biosynthetic process (GO:0046112)2.81951492
129spliceosomal complex assembly (GO:0000245)2.81897247
130deoxyribonucleotide biosynthetic process (GO:0009263)2.81149134
131positive regulation of cell cycle arrest (GO:0071158)2.79801153
132guanosine-containing compound biosynthetic process (GO:1901070)2.79268215
133pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.78389234
134DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.78387789
135cytidine metabolic process (GO:0046087)2.78369053
136cytidine catabolic process (GO:0006216)2.78369053
137cytidine deamination (GO:0009972)2.78369053
138pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.77811922
139mitochondrial respiratory chain complex assembly (GO:0033108)2.76635360
140NADH dehydrogenase complex assembly (GO:0010257)2.76537238

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.69974916
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.16955002
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.07914785
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.87725897
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.69691491
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.53875178
7* EST1_17652178_ChIP-ChIP_JURKAT_Human3.43278155
8* ETS1_20019798_ChIP-Seq_JURKAT_Human3.18390186
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.11613894
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.09023926
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.93275241
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.84260486
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.74577797
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.63730835
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.62411747
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.55485741
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.55260521
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.46073127
19XRN2_22483619_ChIP-Seq_HELA_Human2.42628883
20* VDR_23849224_ChIP-Seq_CD4+_Human2.39083021
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.37706160
22* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.32639022
23DCP1A_22483619_ChIP-Seq_HELA_Human2.30245365
24E2F4_17652178_ChIP-ChIP_JURKAT_Human2.28887481
25E2F1_18555785_ChIP-Seq_MESCs_Mouse2.24183529
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.10495541
27SRF_21415370_ChIP-Seq_HL-1_Mouse2.06001638
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.05975819
29FOXP3_21729870_ChIP-Seq_TREG_Human1.99656487
30GABP_19822575_ChIP-Seq_HepG2_Human1.98961752
31TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.94778109
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.93225751
33CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.90230175
34YY1_21170310_ChIP-Seq_MESCs_Mouse1.90162350
35FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.88383546
36TTF2_22483619_ChIP-Seq_HELA_Human1.88337928
37FOXM1_23109430_ChIP-Seq_U2OS_Human1.88204554
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.81863052
39* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.78095887
40ELK1_19687146_ChIP-ChIP_HELA_Human1.76502537
41MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.75758567
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69370734
43FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.67456334
44* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.65976780
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.60847751
46E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.58694465
47PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.56341680
48ERG_20887958_ChIP-Seq_HPC-7_Mouse1.54362349
49* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53368902
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.50969864
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.48495402
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.46005845
53* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45837620
54SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.45016353
55SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.43243291
56MYCN_18555785_ChIP-Seq_MESCs_Mouse1.39019351
57BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.35725680
58CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32468176
59CIITA_25753668_ChIP-Seq_RAJI_Human1.31394685
60* ELK1_22589737_ChIP-Seq_MCF10A_Human1.30450080
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.29559211
62E2F1_21310950_ChIP-Seq_MCF-7_Human1.25508571
63IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.24057839
64IRF8_22096565_ChIP-ChIP_GC-B_Human1.22005918
65KDM5A_27292631_Chip-Seq_BREAST_Human1.20661508
66* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19318677
67YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17986838
68BCL6_27268052_Chip-Seq_Bcells_Human1.17947953
69ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16316758
70SPI1_23547873_ChIP-Seq_NB4_Human1.16283941
71ELF1_20517297_ChIP-Seq_JURKAT_Human1.16199379
72* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.15372307
73STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12392290
74MAF_26560356_Chip-Seq_TH2_Human1.10433575
75SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10291519
76* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08989129
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.07012475
78VDR_21846776_ChIP-Seq_THP-1_Human1.06980042
79TFEB_21752829_ChIP-Seq_HELA_Human1.05335256
80* TET1_21451524_ChIP-Seq_MESCs_Mouse1.04413350
81DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03891713
82CTCF_18555785_ChIP-Seq_MESCs_Mouse1.03267381
83PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02737483
84GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02680760
85ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.01486486
86AR_21909140_ChIP-Seq_LNCAP_Human1.01084026
87UTX_26944678_Chip-Seq_JUKART_Human1.00281135
88CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99906004
89KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99768532
90* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99449659
91CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99216233
92MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.98950467
93POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98621375
94HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.97671352
95MAF_26560356_Chip-Seq_TH1_Human0.97198999
96* BCOR_27268052_Chip-Seq_Bcells_Human0.95836640
97DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94931848
98ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94857443
99MYB_26560356_Chip-Seq_TH2_Human0.94832621
100MYC_18940864_ChIP-ChIP_HL60_Human0.93647686
101STAT4_19710469_ChIP-ChIP_TH1__Mouse0.93618387
102RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.93543403
103KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93193268
104E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93023359
105FOXP1_21924763_ChIP-Seq_HESCs_Human0.92545687
106PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.90945669
107PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.90380256
108CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.88527703
109MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.87814646
110GATA1_22383799_ChIP-Seq_G1ME_Mouse0.87355721
111SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86838323
112KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.86770773
113TBX5_21415370_ChIP-Seq_HL-1_Mouse0.86645849
114IRF8_21731497_ChIP-ChIP_J774_Mouse0.86235690
115* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.85412657
116CTCF_26484167_Chip-Seq_Bcells_Mouse0.81867864
117YY1_22570637_ChIP-Seq_MALME-3M_Human0.81334717

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.84402332
2MP0004957_abnormal_blastocyst_morpholog3.57291098
3MP0003111_abnormal_nucleus_morphology2.77605932
4MP0010094_abnormal_chromosome_stability2.72552432
5MP0003077_abnormal_cell_cycle2.67235234
6MP0003186_abnormal_redox_activity2.64255249
7MP0008007_abnormal_cellular_replicative2.62112128
8MP0009379_abnormal_foot_pigmentation2.57838086
9MP0008058_abnormal_DNA_repair2.38953523
10MP0003786_premature_aging2.30094309
11MP0008932_abnormal_embryonic_tissue2.19658120
12MP0006082_CNS_inflammation2.18237924
13MP0001835_abnormal_antigen_presentation2.16055054
14MP0003806_abnormal_nucleotide_metabolis2.05205567
15MP0009333_abnormal_splenocyte_physiolog2.03884630
16MP0005058_abnormal_lysosome_morphology2.03427571
17MP0009785_altered_susceptibility_to2.02822440
18MP0000490_abnormal_crypts_of1.98751576
19MP0001790_abnormal_immune_system1.88811609
20MP0005387_immune_system_phenotype1.88811609
21MP0006036_abnormal_mitochondrial_physio1.84506759
22MP0003646_muscle_fatigue1.74330632
23MP0002148_abnormal_hypersensitivity_rea1.66119590
24MP0008057_abnormal_DNA_replication1.64653863
25MP0002132_abnormal_respiratory_system1.54770400
26MP0003315_abnormal_perineum_morphology1.48243601
27MP0003075_altered_response_to1.47727299
28MP0005451_abnormal_body_composition1.47607552
29MP0003763_abnormal_thymus_physiology1.44880838
30MP0000858_altered_metastatic_potential1.42782898
31MP0002396_abnormal_hematopoietic_system1.39701187
32MP0003436_decreased_susceptibility_to1.38803705
33MP0005671_abnormal_response_to1.38239466
34MP0000749_muscle_degeneration1.36802365
35MP0005025_abnormal_response_to1.32791755
36MP0009764_decreased_sensitivity_to1.32678325
37MP0004147_increased_porphyrin_level1.32659627
38MP0002139_abnormal_hepatobiliary_system1.31825376
39MP0001853_heart_inflammation1.30830456
40MP0000372_irregular_coat_pigmentation1.30449715
41MP0003221_abnormal_cardiomyocyte_apopto1.30107810
42MP0005464_abnormal_platelet_physiology1.28090247
43MP0005670_abnormal_white_adipose1.27814500
44MP0002019_abnormal_tumor_incidence1.27153178
45MP0000343_altered_response_to1.23887187
46MP0000313_abnormal_cell_death1.23781714
47MP0001730_embryonic_growth_arrest1.19516661
48MP0010030_abnormal_orbit_morphology1.17863263
49MP0000350_abnormal_cell_proliferation1.17828921
50MP0005379_endocrine/exocrine_gland_phen1.17269149
51MP0003718_maternal_effect1.17203702
52MP0005166_decreased_susceptibility_to1.17013370
53MP0002398_abnormal_bone_marrow1.16883255
54MP0005000_abnormal_immune_tolerance1.15171693
55MP0005084_abnormal_gallbladder_morpholo1.15072911
56MP0003011_delayed_dark_adaptation1.15016925
57MP0000685_abnormal_immune_system1.14730457
58MP0005397_hematopoietic_system_phenotyp1.14567381
59MP0001545_abnormal_hematopoietic_system1.14567381
60MP0002837_dystrophic_cardiac_calcinosis1.13815007
61MP0002138_abnormal_hepatobiliary_system1.13660632
62MP0003303_peritoneal_inflammation1.12069793
63MP0005645_abnormal_hypothalamus_physiol1.11634033
64MP0008875_abnormal_xenobiotic_pharmacok1.11442446
65MP0001905_abnormal_dopamine_level1.10053209
66MP0000750_abnormal_muscle_regeneration1.09892932
67MP0010155_abnormal_intestine_physiology1.09396808
68MP0002405_respiratory_system_inflammati1.09164817
69MP0002429_abnormal_blood_cell1.07753155
70MP0000689_abnormal_spleen_morphology1.07423099
71MP0002722_abnormal_immune_system1.06682107
72MP0006054_spinal_hemorrhage1.06008798
73MP0002452_abnormal_antigen_presenting1.05959321
74MP0005319_abnormal_enzyme/_coenzyme1.05406240
75MP0006035_abnormal_mitochondrial_morpho1.05285507
76MP0010352_gastrointestinal_tract_polyps1.03099689
77MP0002723_abnormal_immune_serum1.02974986
78MP0002877_abnormal_melanocyte_morpholog1.01982952
79MP0001819_abnormal_immune_cell1.01157347
80MP0002420_abnormal_adaptive_immunity1.01120493
81MP0009763_increased_sensitivity_to1.00612472
82MP0005332_abnormal_amino_acid1.00284010
83MP0003724_increased_susceptibility_to1.00160676
84MP0009697_abnormal_copulation0.99724115
85MP0000716_abnormal_immune_system0.98067370
86MP0001764_abnormal_homeostasis0.97089395
87MP0005165_increased_susceptibility_to0.96434393
88MP0004808_abnormal_hematopoietic_stem0.95529129
89MP0001800_abnormal_humoral_immune0.94426099
90MP0004084_abnormal_cardiac_muscle0.94155132
91MP0000358_abnormal_cell_content/0.93096710
92MP0008873_increased_physiological_sensi0.91441449
93MP0005310_abnormal_salivary_gland0.91413869
94MP0002166_altered_tumor_susceptibility0.89911591
95MP0005584_abnormal_enzyme/coenzyme_acti0.89882091
96MP0009643_abnormal_urine_homeostasis0.89575967
97MP0003191_abnormal_cellular_cholesterol0.89018828
98MP0002163_abnormal_gland_morphology0.88741986
99MP0001533_abnormal_skeleton_physiology0.88303338
100MP0009840_abnormal_foam_cell0.87812604
101MP0001845_abnormal_inflammatory_respons0.87002736
102MP0001727_abnormal_embryo_implantation0.86671751
103MP0005330_cardiomyopathy0.86162703
104MP0001697_abnormal_embryo_size0.86014557
105MP0008469_abnormal_protein_level0.85919478
106MP0002080_prenatal_lethality0.85873956
107MP0002419_abnormal_innate_immunity0.85442845
108MP0000703_abnormal_thymus_morphology0.84872492
109MP0005408_hypopigmentation0.84760104
110MP0008995_early_reproductive_senescence0.83230913
111MP0005075_abnormal_melanosome_morpholog0.81396052
112MP0003941_abnormal_skin_development0.79899976
113MP0003195_calcinosis0.79556764
114MP0003172_abnormal_lysosome_physiology0.79138231
115MP0003656_abnormal_erythrocyte_physiolo0.77939988
116MP0002638_abnormal_pupillary_reflex0.76969990
117MP0003123_paternal_imprinting0.76861938
118MP0002277_abnormal_respiratory_mucosa0.76797310
119MP0005360_urolithiasis0.76639892
120MP0001873_stomach_inflammation0.76365819
121MP0002693_abnormal_pancreas_physiology0.75353459
122MP0002933_joint_inflammation0.74872890
123MP0003448_altered_tumor_morphology0.74188244
124MP0002938_white_spotting0.73628206
125MP0003984_embryonic_growth_retardation0.72443507
126MP0003567_abnormal_fetal_cardiomyocyte0.72350310
127MP0002160_abnormal_reproductive_system0.72161215
128MP0005636_abnormal_mineral_homeostasis0.72132022
129MP0001672_abnormal_embryogenesis/_devel0.70676486
130MP0005380_embryogenesis_phenotype0.70676486
131MP0008877_abnormal_DNA_methylation0.69878706
132MP0004782_abnormal_surfactant_physiolog0.69862426
133MP0001542_abnormal_bone_strength0.69765344
134MP0003866_abnormal_defecation0.69113763
135MP0005389_reproductive_system_phenotype0.68898635
136MP0002088_abnormal_embryonic_growth/wei0.68140773
137MP0001663_abnormal_digestive_system0.67621611

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.66845303
2Abnormal number of erythroid precursors (HP:0012131)5.39126596
3Reticulocytopenia (HP:0001896)5.11197694
4Acute necrotizing encephalopathy (HP:0006965)4.51038834
5Mitochondrial inheritance (HP:0001427)4.36759782
6Abnormal mitochondria in muscle tissue (HP:0008316)4.12688849
7Hepatocellular necrosis (HP:0001404)4.05936555
8Hepatic necrosis (HP:0002605)3.96424844
9Increased CSF lactate (HP:0002490)3.92251516
10Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.85872242
11Increased hepatocellular lipid droplets (HP:0006565)3.85414732
12Decreased activity of mitochondrial respiratory chain (HP:0008972)3.84022782
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.84022782
14Macrocytic anemia (HP:0001972)3.63052110
15Acute encephalopathy (HP:0006846)3.61394326
16Lipid accumulation in hepatocytes (HP:0006561)3.58883450
17Pallor (HP:0000980)3.50245983
18Progressive macrocephaly (HP:0004481)3.47345869
19Exertional dyspnea (HP:0002875)3.43499799
20Increased serum lactate (HP:0002151)3.37409781
21Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.34732460
22Aplasia/Hypoplasia of the sacrum (HP:0008517)3.26394268
23Aplastic anemia (HP:0001915)3.24311461
24Exercise intolerance (HP:0003546)3.14637320
25Increased intramyocellular lipid droplets (HP:0012240)2.92611134
26Lactic acidosis (HP:0003128)2.85104773
27Renal Fanconi syndrome (HP:0001994)2.84706913
2811 pairs of ribs (HP:0000878)2.79875706
29Carpal bone hypoplasia (HP:0001498)2.76611081
303-Methylglutaconic aciduria (HP:0003535)2.75103697
31Oral leukoplakia (HP:0002745)2.74182063
32Respiratory failure (HP:0002878)2.69728251
33Increased muscle lipid content (HP:0009058)2.69088576
34Type I transferrin isoform profile (HP:0003642)2.65784247
35Cerebral edema (HP:0002181)2.58843758
36Breast hypoplasia (HP:0003187)2.53462803
37Thrombocytosis (HP:0001894)2.49705792
38Rough bone trabeculation (HP:0100670)2.49355992
39Vacuolated lymphocytes (HP:0001922)2.48342541
40Poor head control (HP:0002421)2.45957745
41Birth length less than 3rd percentile (HP:0003561)2.45794702
42Microretrognathia (HP:0000308)2.45266850
43Respiratory difficulties (HP:0002880)2.43153624
44Abnormality of glycolipid metabolism (HP:0010969)2.40719185
45Abnormality of liposaccharide metabolism (HP:0010968)2.40719185
46Abnormality of glycosphingolipid metabolism (HP:0004343)2.40719185
47Microvesicular hepatic steatosis (HP:0001414)2.39502406
48Progressive muscle weakness (HP:0003323)2.31670783
49Degeneration of anterior horn cells (HP:0002398)2.30805745
50Abnormality of the anterior horn cell (HP:0006802)2.30805745
51Obstructive lung disease (HP:0006536)2.26500498
52Chronic obstructive pulmonary disease (HP:0006510)2.26500498
53Cleft eyelid (HP:0000625)2.26462494
54Multiple enchondromatosis (HP:0005701)2.25522474
55Mediastinal lymphadenopathy (HP:0100721)2.21987024
56Trismus (HP:0000211)2.21917642
57Testicular atrophy (HP:0000029)2.17225747
58Abnormal hemoglobin (HP:0011902)2.15783505
59Irregular epiphyses (HP:0010582)2.15730078
60Reduced antithrombin III activity (HP:0001976)2.15333229
61Petechiae (HP:0000967)2.13209456
62Ragged-red muscle fibers (HP:0003200)2.11594079
63Agammaglobulinemia (HP:0004432)2.09812079
64Nausea (HP:0002018)2.09452699
65Abnormality of macrophages (HP:0004311)2.08759526
66Generalized aminoaciduria (HP:0002909)2.07870858
67Increased IgM level (HP:0003496)2.07402485
68IgG deficiency (HP:0004315)2.04294910
69Glycosuria (HP:0003076)2.04219159
70Abnormality of urine glucose concentration (HP:0011016)2.04219159
71Abnormality of reticulocytes (HP:0004312)2.04011027
72Pancytopenia (HP:0001876)2.00933033
73Abnormal glycosylation (HP:0012345)1.98984191
74Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.98984191
75Abnormal protein N-linked glycosylation (HP:0012347)1.98984191
76Abnormal protein glycosylation (HP:0012346)1.98984191
77Absent thumb (HP:0009777)1.96925760
78Stomatitis (HP:0010280)1.96007431
79Rhabdomyolysis (HP:0003201)1.93463034
80Recurrent abscess formation (HP:0002722)1.92863463
81Abnormality of renal resorption (HP:0011038)1.89452415
82Methylmalonic aciduria (HP:0012120)1.89426125
83Increased serum ferritin (HP:0003281)1.89060070
84Abnormality of the heme biosynthetic pathway (HP:0010472)1.88957625
85Optic disc pallor (HP:0000543)1.88679900
86Hepatosplenomegaly (HP:0001433)1.87732423
87Abnormality of aromatic amino acid family metabolism (HP:0004338)1.87136687
88CNS demyelination (HP:0007305)1.85834825
89Hyperphosphaturia (HP:0003109)1.85365079
90Patent foramen ovale (HP:0001655)1.85237001
91Increased neuronal autofluorescent lipopigment (HP:0002074)1.84505174
92Hypertensive crisis (HP:0100735)1.84484256
93Muscle fiber atrophy (HP:0100295)1.84204550
94Abnormal trabecular bone morphology (HP:0100671)1.83711016
95Recurrent bacterial skin infections (HP:0005406)1.82155636
96Vomiting (HP:0002013)1.81715500
97Opisthotonus (HP:0002179)1.81361163
98Prolonged neonatal jaundice (HP:0006579)1.80860484
99Gliosis (HP:0002171)1.77974466
100Increased cerebral lipofuscin (HP:0011813)1.76533868
101B lymphocytopenia (HP:0010976)1.76361578
102Secondary amenorrhea (HP:0000869)1.76137817
103Progressive neurologic deterioration (HP:0002344)1.76096795
104Palpitations (HP:0001962)1.75737536
105Elevated erythrocyte sedimentation rate (HP:0003565)1.75703726
106Premature graying of hair (HP:0002216)1.75688213
107Decreased electroretinogram (ERG) amplitude (HP:0000654)1.74158075
108Severe combined immunodeficiency (HP:0004430)1.74060659
109Neoplasm of the adrenal gland (HP:0100631)1.74031203
110Cerebral hypomyelination (HP:0006808)1.73686764
111Dicarboxylic aciduria (HP:0003215)1.73420854
112Abnormality of dicarboxylic acid metabolism (HP:0010995)1.73420854
113Lethargy (HP:0001254)1.72982156
114Neutropenia (HP:0001875)1.72914258
115Patellar aplasia (HP:0006443)1.72574184
116Abnormality of the prostate (HP:0008775)1.72225250
117Acute hepatic failure (HP:0006554)1.72134295
118Cerebral palsy (HP:0100021)1.72065877
119Sparse eyelashes (HP:0000653)1.69433498
120Aplasia/Hypoplasia of the patella (HP:0006498)1.69159377
121Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.68925800
122Abnormality of the preputium (HP:0100587)1.67024628
123Type 2 muscle fiber atrophy (HP:0003554)1.66115692
124IgM deficiency (HP:0002850)1.64603878
125Emotional lability (HP:0000712)1.63821508
126Vertebral compression fractures (HP:0002953)1.62040979
127Bone marrow hypocellularity (HP:0005528)1.61777646
128Genu varum (HP:0002970)1.61462938
129Abnormality of T cell physiology (HP:0011840)1.59265146
130Triphalangeal thumb (HP:0001199)1.57513812
131Chromsome breakage (HP:0040012)1.54281797
132Pulmonary fibrosis (HP:0002206)1.54189575
133Redundant skin (HP:0001582)1.53905951
134Leukodystrophy (HP:0002415)1.53296621
135Hyperalaninemia (HP:0003348)1.51784191

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.70655048
2BUB14.42284820
3VRK24.09167701
4STK163.52490913
5EIF2AK12.65785266
6WEE12.65174151
7TESK12.52704100
8PIM22.47831386
9TLK12.22878779
10SRPK12.17590832
11MST42.07953256
12PBK1.96740614
13PLK41.96687611
14EIF2AK31.88793367
15TESK21.87619892
16VRK11.82606815
17KDR1.78295909
18MYLK1.63917871
19ZAK1.61813070
20NME11.61527694
21BCKDK1.59924161
22TAOK31.57690171
23RPS6KA41.54388547
24IRAK31.53798649
25BRSK21.51835021
26CDK191.50539491
27MAP3K111.48355659
28ACVR1B1.42344550
29PRKG21.38570903
30CDC71.29643299
31MAP4K21.28495120
32IRAK41.26549523
33AURKB1.25193396
34BRAF1.20088254
35LIMK11.17001361
36RPS6KB21.15827322
37PLK11.14552593
38MKNK11.14203437
39OBSCN1.12304379
40DAPK11.10016154
41PDK21.06372137
42MAP4K11.06188962
43DYRK31.04958335
44MKNK21.04792780
45AURKA1.04365847
46STK38L1.04313571
47TBK11.03363887
48NEK21.03156606
49GRK71.03152359
50BLK1.01786446
51BRSK11.01223453
52TNK20.99867093
53STK240.97616369
54CDK70.96147009
55ILK0.95579019
56LRRK20.94602425
57GRK60.94515037
58PIM10.93564127
59ABL20.92740027
60TTK0.91111785
61IKBKE0.90998051
62IKBKB0.90813888
63NUAK10.88445794
64MAP3K120.84364314
65ARAF0.82904800
66CCNB10.81041443
67ATR0.80954343
68FLT30.80102901
69STK40.77716173
70NEK90.77650004
71PASK0.76476770
72ZAP700.76254882
73CDK80.75875653
74TEC0.75395304
75CDK40.75273442
76EIF2AK20.74291545
77CSNK2A10.73220381
78CHEK20.73127018
79BMPR20.71918890
80PIK3CA0.71499040
81MAP3K80.70855686
82PAK40.70593296
83PAK10.70165131
84BTK0.69068172
85ADRBK20.67975255
86CSNK1G30.67809176
87PIK3CG0.64226216
88RPS6KA50.63780697
89FES0.63330678
90TYK20.63008549
91DAPK30.60952870
92ITK0.60691093
93MAP3K30.60433508
94SCYL20.59614416
95NEK10.59477916
96PRKCI0.59282272
97JAK30.58352645
98MAP2K20.57819929
99TXK0.57422483
100KIT0.54583502
101SYK0.51938597
102EPHA20.51936517
103ERN10.51161978
104TAOK20.49818044
105CSNK2A20.49736478
106PRKCQ0.49668480
107MAP2K60.48849283
108MATK0.48418384
109DYRK20.47576547
110CSF1R0.47510973
111STK100.46145413
112TGFBR10.45764601
113PLK30.45272753
114MAP2K30.42827888
115GRK50.41952107
116MAPKAPK20.41605249
117MAP3K140.41488823
118LMTK20.40888321
119CLK10.40742532
120LCK0.40410180
121MAPKAPK30.40065106
122LYN0.38056941
123IRAK10.38028716
124RIPK40.37097460
125RPS6KA60.35267311
126SMG10.34576812
127MARK30.34496567
128MAP3K50.34397038
129CSNK1A1L0.34266293
130GRK10.33259200
131MUSK0.31038137
132PKN10.30495617
133TAOK10.29319239

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.13548355
2Proteasome_Homo sapiens_hsa030504.19365911
3DNA replication_Homo sapiens_hsa030304.00242691
4RNA polymerase_Homo sapiens_hsa030203.20312044
5Mismatch repair_Homo sapiens_hsa034303.15229495
6Oxidative phosphorylation_Homo sapiens_hsa001903.02703582
7Parkinsons disease_Homo sapiens_hsa050122.88254647
8Homologous recombination_Homo sapiens_hsa034402.57732462
9Pyrimidine metabolism_Homo sapiens_hsa002402.52455053
10Base excision repair_Homo sapiens_hsa034102.39169581
11Spliceosome_Homo sapiens_hsa030402.37114001
12Protein export_Homo sapiens_hsa030602.35749074
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.34994356
14Nucleotide excision repair_Homo sapiens_hsa034202.29523832
15Huntingtons disease_Homo sapiens_hsa050162.24875554
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.92455051
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.89972718
18Alzheimers disease_Homo sapiens_hsa050101.82190208
19RNA transport_Homo sapiens_hsa030131.71318643
20Fatty acid elongation_Homo sapiens_hsa000621.49496130
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.48787339
22One carbon pool by folate_Homo sapiens_hsa006701.42623502
23Cell cycle_Homo sapiens_hsa041101.42179815
24Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.34767914
25Fanconi anemia pathway_Homo sapiens_hsa034601.33890113
26Folate biosynthesis_Homo sapiens_hsa007901.32897932
27Type I diabetes mellitus_Homo sapiens_hsa049401.32609833
28Basal transcription factors_Homo sapiens_hsa030221.32431641
29Purine metabolism_Homo sapiens_hsa002301.31758363
30RNA degradation_Homo sapiens_hsa030181.31000255
31Sulfur relay system_Homo sapiens_hsa041221.23189520
32Rheumatoid arthritis_Homo sapiens_hsa053231.21195729
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.12414315
34Cardiac muscle contraction_Homo sapiens_hsa042601.06822250
35Pentose phosphate pathway_Homo sapiens_hsa000301.02231052
36Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99109342
37p53 signaling pathway_Homo sapiens_hsa041150.97870145
38Non-homologous end-joining_Homo sapiens_hsa034500.96427021
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94759465
40Glutathione metabolism_Homo sapiens_hsa004800.91677112
41Legionellosis_Homo sapiens_hsa051340.89314908
42Epstein-Barr virus infection_Homo sapiens_hsa051690.86727384
43Systemic lupus erythematosus_Homo sapiens_hsa053220.86603018
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.86571796
45Galactose metabolism_Homo sapiens_hsa000520.82653955
46Collecting duct acid secretion_Homo sapiens_hsa049660.82653172
47Viral myocarditis_Homo sapiens_hsa054160.80379512
48Antigen processing and presentation_Homo sapiens_hsa046120.75797342
49Herpes simplex infection_Homo sapiens_hsa051680.73404998
50Staphylococcus aureus infection_Homo sapiens_hsa051500.71465750
51Fructose and mannose metabolism_Homo sapiens_hsa000510.70838128
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.70586441
53Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67451650
54Allograft rejection_Homo sapiens_hsa053300.66209070
55Carbon metabolism_Homo sapiens_hsa012000.65226440
56Asthma_Homo sapiens_hsa053100.64939835
57Lysosome_Homo sapiens_hsa041420.64374095
58Arachidonic acid metabolism_Homo sapiens_hsa005900.63750185
59Intestinal immune network for IgA production_Homo sapiens_hsa046720.63188483
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61257516
61Metabolic pathways_Homo sapiens_hsa011000.60404583
62Primary bile acid biosynthesis_Homo sapiens_hsa001200.57959099
63Primary immunodeficiency_Homo sapiens_hsa053400.57485588
64Vitamin B6 metabolism_Homo sapiens_hsa007500.56183915
65Selenocompound metabolism_Homo sapiens_hsa004500.55232458
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54665674
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.54609076
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.53971337
69Graft-versus-host disease_Homo sapiens_hsa053320.53771237
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52936300
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51815365
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51779103
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51407965
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51152309
75Glycosaminoglycan degradation_Homo sapiens_hsa005310.51129232
76mRNA surveillance pathway_Homo sapiens_hsa030150.50130281
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49799518
78Vibrio cholerae infection_Homo sapiens_hsa051100.49715430
79Other glycan degradation_Homo sapiens_hsa005110.48972498
80Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.48904424
81Biosynthesis of amino acids_Homo sapiens_hsa012300.48877463
82Tyrosine metabolism_Homo sapiens_hsa003500.48670840
83Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48435271
84Measles_Homo sapiens_hsa051620.48033157
85N-Glycan biosynthesis_Homo sapiens_hsa005100.48025548
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47352534
87Viral carcinogenesis_Homo sapiens_hsa052030.45844015
88Propanoate metabolism_Homo sapiens_hsa006400.43685194
89Sulfur metabolism_Homo sapiens_hsa009200.43595641
90Apoptosis_Homo sapiens_hsa042100.43575623
91Salmonella infection_Homo sapiens_hsa051320.42602784
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.41860267
93Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41694564
94Chemical carcinogenesis_Homo sapiens_hsa052040.41199761
95Cyanoamino acid metabolism_Homo sapiens_hsa004600.40821902
96Fatty acid metabolism_Homo sapiens_hsa012120.37597173
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35323247
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34619602
99Fatty acid degradation_Homo sapiens_hsa000710.33966878
100Leishmaniasis_Homo sapiens_hsa051400.33744721
101Influenza A_Homo sapiens_hsa051640.33625241
102Tryptophan metabolism_Homo sapiens_hsa003800.33460283
103Autoimmune thyroid disease_Homo sapiens_hsa053200.32287260
104Tuberculosis_Homo sapiens_hsa051520.31963121
1052-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.31806960
106Phagosome_Homo sapiens_hsa041450.31354061
107Hematopoietic cell lineage_Homo sapiens_hsa046400.29900682
108Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.29398040
109HTLV-I infection_Homo sapiens_hsa051660.28874244
110Malaria_Homo sapiens_hsa051440.28123060
111Shigellosis_Homo sapiens_hsa051310.27924863
112Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.26728802
113Pyruvate metabolism_Homo sapiens_hsa006200.26541506
114Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.25983497
115Maturity onset diabetes of the young_Homo sapiens_hsa049500.25551763
116Arginine and proline metabolism_Homo sapiens_hsa003300.25423585
117Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.23745653
118Regulation of autophagy_Homo sapiens_hsa041400.22503556
119Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19095552
120Peroxisome_Homo sapiens_hsa041460.17828298
121Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.17682256
122Hepatitis B_Homo sapiens_hsa051610.17269622
123Linoleic acid metabolism_Homo sapiens_hsa005910.16526512
124Phenylalanine metabolism_Homo sapiens_hsa003600.16040747
125Thyroid cancer_Homo sapiens_hsa052160.15618346
126Pertussis_Homo sapiens_hsa051330.15006031
127Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.13438916

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