MRPL57

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a protein which belongs to an undetermined ribosomal subunit and which seems to be specific to animal mitoribosomes. Pseudogenes corresponding to this gene are found on chromosomes 1p, 1q, 3p, 5q, 8q, 14q, and Y. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.79405064
2ribosomal small subunit assembly (GO:0000028)6.20464915
3chaperone-mediated protein transport (GO:0072321)6.00628656
4viral transcription (GO:0019083)5.32926172
5establishment of protein localization to mitochondrial membrane (GO:0090151)5.30045660
6translational termination (GO:0006415)5.19217421
7proteasome assembly (GO:0043248)5.08902157
8electron transport chain (GO:0022900)5.05140987
9ribosomal small subunit biogenesis (GO:0042274)4.99511334
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.98354900
11cotranslational protein targeting to membrane (GO:0006613)4.88957378
12protein targeting to ER (GO:0045047)4.85228379
13translational elongation (GO:0006414)4.65774455
14ribosomal large subunit biogenesis (GO:0042273)4.64635242
15protein localization to endoplasmic reticulum (GO:0070972)4.64253285
16deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.63850800
17establishment of protein localization to endoplasmic reticulum (GO:0072599)4.57944489
18maturation of SSU-rRNA (GO:0030490)4.56868278
19translational initiation (GO:0006413)4.16846616
20telomere maintenance via semi-conservative replication (GO:0032201)4.13613870
21* translation (GO:0006412)4.12386710
22viral life cycle (GO:0019058)4.11652613
23termination of RNA polymerase III transcription (GO:0006386)4.09826258
24transcription elongation from RNA polymerase III promoter (GO:0006385)4.09826258
25cellular protein complex disassembly (GO:0043624)4.09115850
26pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.01596014
27regulation of mitochondrial translation (GO:0070129)3.98340128
28negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.96864615
29nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.96009672
30mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.94398994
31RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.90749783
32tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.90749783
33DNA strand elongation involved in DNA replication (GO:0006271)3.88322885
34ribonucleoprotein complex biogenesis (GO:0022613)3.88314362
35protein neddylation (GO:0045116)3.79754532
36water-soluble vitamin biosynthetic process (GO:0042364)3.76069164
37DNA strand elongation (GO:0022616)3.75029164
38pseudouridine synthesis (GO:0001522)3.73361513
39energy coupled proton transport, down electrochemical gradient (GO:0015985)3.73115775
40ATP synthesis coupled proton transport (GO:0015986)3.73115775
41base-excision repair, AP site formation (GO:0006285)3.72989442
42positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.68459192
43protein localization to mitochondrion (GO:0070585)3.64792901
44regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.64229486
45spliceosomal snRNP assembly (GO:0000387)3.62140811
46telomere maintenance via recombination (GO:0000722)3.60514986
47regulation of cellular amino acid metabolic process (GO:0006521)3.59859268
48protein complex biogenesis (GO:0070271)3.59230675
49antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.58565922
50negative regulation of ligase activity (GO:0051352)3.57708095
51negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.57708095
52DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.57654835
53cellular component biogenesis (GO:0044085)3.56507570
54deoxyribose phosphate biosynthetic process (GO:0046385)3.56030360
552-deoxyribonucleotide biosynthetic process (GO:0009265)3.56030360
56anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.53598914
57DNA replication checkpoint (GO:0000076)3.51634157
58protein deneddylation (GO:0000338)3.51587944
59intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.51080592
60signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.51080592
61rRNA modification (GO:0000154)3.51012470
62signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.50845315
63signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.50845315
64signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.50845315
65ATP biosynthetic process (GO:0006754)3.50385332
66exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.50379601
67mitochondrial respiratory chain complex assembly (GO:0033108)3.49803892
68oxidative phosphorylation (GO:0006119)3.49055786
69protein complex disassembly (GO:0043241)3.48627138
70rRNA processing (GO:0006364)3.48535765
71L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.47389247
72metallo-sulfur cluster assembly (GO:0031163)3.46929936
73iron-sulfur cluster assembly (GO:0016226)3.46929936
747-methylguanosine mRNA capping (GO:0006370)3.44646163
75purine nucleoside triphosphate biosynthetic process (GO:0009145)3.44496381
76cullin deneddylation (GO:0010388)3.43706967
77deoxyribonucleotide biosynthetic process (GO:0009263)3.42819578
78protein-cofactor linkage (GO:0018065)3.42325360
79mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.42075276
80mitochondrial respiratory chain complex I assembly (GO:0032981)3.42075276
81NADH dehydrogenase complex assembly (GO:0010257)3.42075276
82deoxyribonucleotide catabolic process (GO:0009264)3.41995766
83purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.41557087
84nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.40909909
85antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.40164818
86protein targeting to mitochondrion (GO:0006626)3.39247423
87DNA replication initiation (GO:0006270)3.39045671
88respiratory chain complex IV assembly (GO:0008535)3.38789313
89signal transduction involved in DNA damage checkpoint (GO:0072422)3.38132437
90signal transduction involved in DNA integrity checkpoint (GO:0072401)3.38132437
91rRNA metabolic process (GO:0016072)3.36741236
927-methylguanosine RNA capping (GO:0009452)3.36676954
93RNA capping (GO:0036260)3.36676954
94macromolecular complex disassembly (GO:0032984)3.36588666
95signal transduction involved in cell cycle checkpoint (GO:0072395)3.34599232
96hydrogen ion transmembrane transport (GO:1902600)3.33400502
97guanosine-containing compound biosynthetic process (GO:1901070)3.33007155
98GTP biosynthetic process (GO:0006183)3.30923762
99nucleobase-containing small molecule interconversion (GO:0015949)3.28755716
100mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.28662393
101establishment of protein localization to mitochondrion (GO:0072655)3.27883999
102deoxyribose phosphate catabolic process (GO:0046386)3.27126925
103CENP-A containing nucleosome assembly (GO:0034080)3.25454294
104chromatin remodeling at centromere (GO:0031055)3.23498586
105ribosome biogenesis (GO:0042254)3.23253199
106GDP-mannose metabolic process (GO:0019673)3.23191313
107telomere maintenance via telomere lengthening (GO:0010833)3.23125369
108formation of translation preinitiation complex (GO:0001731)3.22764584
109pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.21893654
110positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.21798742
111mitotic recombination (GO:0006312)3.19569072
112maturation of 5.8S rRNA (GO:0000460)3.19371923
113intracellular protein transmembrane import (GO:0044743)3.19278341
114pyrimidine nucleotide catabolic process (GO:0006244)3.18629770
115transcription-coupled nucleotide-excision repair (GO:0006283)3.18423474
116nuclear-transcribed mRNA catabolic process (GO:0000956)3.15811227
117protein targeting to membrane (GO:0006612)3.15746170
118positive regulation of ligase activity (GO:0051351)3.15262599
119cytochrome complex assembly (GO:0017004)3.15226787
120respiratory electron transport chain (GO:0022904)3.14796543
121deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.14079136
122mitochondrial transport (GO:0006839)3.13291202
123ribonucleoside triphosphate biosynthetic process (GO:0009201)3.10210690
124ubiquinone biosynthetic process (GO:0006744)3.07680592
125DNA damage response, detection of DNA damage (GO:0042769)3.07558701
126inner mitochondrial membrane organization (GO:0007007)3.01188911
127tRNA processing (GO:0008033)2.98416682
128proton transport (GO:0015992)2.98351994
129purine deoxyribonucleotide catabolic process (GO:0009155)2.96014202
130hydrogen transport (GO:0006818)2.91878917
131mRNA catabolic process (GO:0006402)2.90927845
132mannosylation (GO:0097502)2.89895647
133nucleoside triphosphate biosynthetic process (GO:0009142)2.85418746
134peptidyl-histidine modification (GO:0018202)2.81853132

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.11172797
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.49171841
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.32589714
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.09887546
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.04659167
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.92019452
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.64252156
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.51966293
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.46896934
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.23282891
11MYC_18358816_ChIP-ChIP_MESCs_Mouse3.19862665
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.13383919
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.91715276
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.90104386
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.79362991
16VDR_23849224_ChIP-Seq_CD4+_Human2.72132992
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.70201505
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.61591076
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.54950194
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.53875711
21DCP1A_22483619_ChIP-Seq_HELA_Human2.48238719
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.47376200
23XRN2_22483619_ChIP-Seq_HELA_Human2.40116131
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.38624464
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.31232255
26E2F1_18555785_ChIP-Seq_MESCs_Mouse2.30785325
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.26488554
28FOXP3_21729870_ChIP-Seq_TREG_Human2.24745879
29SRF_21415370_ChIP-Seq_HL-1_Mouse2.22533687
30NELFA_20434984_ChIP-Seq_ESCs_Mouse2.16955467
31GABP_19822575_ChIP-Seq_HepG2_Human2.15225548
32THAP11_20581084_ChIP-Seq_MESCs_Mouse2.11082411
33YY1_21170310_ChIP-Seq_MESCs_Mouse2.06656834
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.05310132
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.03503746
36TTF2_22483619_ChIP-Seq_HELA_Human2.01948059
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.00124729
38FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.99570985
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87116053
40ELK1_19687146_ChIP-ChIP_HELA_Human1.86688912
41MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.85217051
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.85187763
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.81457908
44CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.79196091
45ZNF274_21170338_ChIP-Seq_K562_Hela1.76382428
46ERG_20887958_ChIP-Seq_HPC-7_Mouse1.69837106
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.63303057
48SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.56402415
49FOXM1_23109430_ChIP-Seq_U2OS_Human1.55799256
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.55320648
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.53159583
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.52781677
53POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49100191
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48093936
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47897990
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.44375762
57ELK1_22589737_ChIP-Seq_MCF10A_Human1.39562812
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.35596683
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35332304
60CIITA_25753668_ChIP-Seq_RAJI_Human1.31137984
61E2F1_21310950_ChIP-Seq_MCF-7_Human1.30672802
62MYC_18940864_ChIP-ChIP_HL60_Human1.26704854
63IRF1_19129219_ChIP-ChIP_H3396_Human1.25710364
64BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.21741340
65KDM5A_27292631_Chip-Seq_BREAST_Human1.20161072
66VDR_22108803_ChIP-Seq_LS180_Human1.17807494
67IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.17535055
68SPI1_23547873_ChIP-Seq_NB4_Human1.16417742
69TP53_22573176_ChIP-Seq_HFKS_Human1.15709322
70EWS_26573619_Chip-Seq_HEK293_Human1.13875526
71GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.12458481
72CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11404372
73SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08859849
74POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08479544
75EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06915685
76CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06539429
77ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04593551
78ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04354789
79AR_21909140_ChIP-Seq_LNCAP_Human1.04072847
80HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.03435262
81TFEB_21752829_ChIP-Seq_HELA_Human1.01659218
82E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00933650
83CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99945250
84CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97037116
85CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95894199
86CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.94257446
87FOXP1_21924763_ChIP-Seq_HESCs_Human0.92667490
88TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.92376259
89SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.92163747
90PADI4_21655091_ChIP-ChIP_MCF-7_Human0.91824213
91SOX2_16153702_ChIP-ChIP_HESCs_Human0.90035032
92IGF1R_20145208_ChIP-Seq_DFB_Human0.89806423
93FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89590935
94ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.89143326
95HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.87759751
96RBPJ_22232070_ChIP-Seq_NCS_Mouse0.87686710
97STAT4_19710469_ChIP-ChIP_TH1__Mouse0.87299584
98SOX2_18555785_ChIP-Seq_MESCs_Mouse0.86467706
99EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.86420093
100KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.85761702
101RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.85665110
102AR_20517297_ChIP-Seq_VCAP_Human0.85474288
103SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85365867
104PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.84916999
105BP1_19119308_ChIP-ChIP_Hs578T_Human0.84865218
106STAT3_1855785_ChIP-Seq_MESCs_Mouse0.84413775
107DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.84387956
108GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84324308
109FOXA1_27270436_Chip-Seq_PROSTATE_Human0.83245468
110FOXA1_25329375_ChIP-Seq_VCAP_Human0.83245468
111KLF4_18555785_ChIP-Seq_MESCs_Mouse0.82848639
112POU5F1_16153702_ChIP-ChIP_HESCs_Human0.82061990
113FLI1_27457419_Chip-Seq_LIVER_Mouse0.81548870
114DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.80726805
115HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.80638533
116IRF8_22096565_ChIP-ChIP_GC-B_Human0.79637204
117HTT_18923047_ChIP-ChIP_STHdh_Human0.77710386
118MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.77151488
119RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.76117722
120MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.75164257
121TBX5_21415370_ChIP-Seq_HL-1_Mouse0.75004988
122ERG_20517297_ChIP-Seq_VCAP_Human0.73029950
123ELF5_23300383_ChIP-Seq_T47D_Human0.72921455
124FUS_26573619_Chip-Seq_HEK293_Human0.72899098
125NANOG_20526341_ChIP-Seq_ESCs_Human0.72115978
126VDR_21846776_ChIP-Seq_THP-1_Human0.72031290
127PU.1_20513432_ChIP-Seq_Bcells_Mouse0.71768533

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.61464111
2MP0009379_abnormal_foot_pigmentation3.85546495
3MP0004957_abnormal_blastocyst_morpholog3.73035412
4MP0003111_abnormal_nucleus_morphology3.24261598
5MP0010094_abnormal_chromosome_stability3.19867766
6MP0008058_abnormal_DNA_repair3.05976009
7MP0003077_abnormal_cell_cycle2.95946554
8MP0008932_abnormal_embryonic_tissue2.71555684
9MP0003186_abnormal_redox_activity2.61991255
10MP0006036_abnormal_mitochondrial_physio2.24599167
11MP0008057_abnormal_DNA_replication2.19295649
12MP0002837_dystrophic_cardiac_calcinosis2.18706557
13MP0003786_premature_aging2.14069473
14MP0002938_white_spotting2.13153356
15MP0008007_abnormal_cellular_replicative2.08207796
16MP0009333_abnormal_splenocyte_physiolog2.05807692
17MP0002396_abnormal_hematopoietic_system2.04399449
18MP0002132_abnormal_respiratory_system2.04081814
19MP0000490_abnormal_crypts_of1.99675405
20MP0003656_abnormal_erythrocyte_physiolo1.99116971
21MP0004147_increased_porphyrin_level1.96699707
22MP0005075_abnormal_melanosome_morpholog1.92428514
23MP0006072_abnormal_retinal_apoptosis1.90248132
24MP0003718_maternal_effect1.87968483
25MP0003806_abnormal_nucleotide_metabolis1.86610413
26MP0008875_abnormal_xenobiotic_pharmacok1.86318172
27MP0003724_increased_susceptibility_to1.84173131
28MP0003136_yellow_coat_color1.83891944
29MP0005645_abnormal_hypothalamus_physiol1.82109527
30MP0002653_abnormal_ependyma_morphology1.78396111
31MP0003011_delayed_dark_adaptation1.78160983
32MP0003763_abnormal_thymus_physiology1.75296620
33MP0001835_abnormal_antigen_presentation1.72533313
34MP0008789_abnormal_olfactory_epithelium1.64516458
35MP0009785_altered_susceptibility_to1.63176705
36MP0002148_abnormal_hypersensitivity_rea1.58021739
37MP0002736_abnormal_nociception_after1.57712275
38MP0005646_abnormal_pituitary_gland1.57081233
39MP0006035_abnormal_mitochondrial_morpho1.55322368
40MP0009697_abnormal_copulation1.55045270
41MP0005671_abnormal_response_to1.55028478
42MP0008872_abnormal_physiological_respon1.52537599
43MP0001545_abnormal_hematopoietic_system1.52456242
44MP0005397_hematopoietic_system_phenotyp1.52456242
45MP0001188_hyperpigmentation1.51926089
46MP0004142_abnormal_muscle_tone1.51717950
47MP0001764_abnormal_homeostasis1.47367762
48MP0001905_abnormal_dopamine_level1.46303386
49MP0001485_abnormal_pinna_reflex1.45849320
50MP0003787_abnormal_imprinting1.44414877
51MP0006054_spinal_hemorrhage1.42913887
52MP0005551_abnormal_eye_electrophysiolog1.40355953
53MP0001968_abnormal_touch/_nociception1.39974754
54MP0006292_abnormal_olfactory_placode1.38783033
55MP0005379_endocrine/exocrine_gland_phen1.38779504
56MP0003195_calcinosis1.37728810
57MP0002277_abnormal_respiratory_mucosa1.35360711
58MP0000313_abnormal_cell_death1.31542194
59MP0004381_abnormal_hair_follicle1.30610696
60MP0001529_abnormal_vocalization1.30108840
61MP0002398_abnormal_bone_marrow1.29769866
62MP0004145_abnormal_muscle_electrophysio1.27815979
63MP0003436_decreased_susceptibility_to1.25878720
64MP0002019_abnormal_tumor_incidence1.23584037
65MP0002722_abnormal_immune_system1.21977701
66MP0002876_abnormal_thyroid_physiology1.20997864
67MP0002102_abnormal_ear_morphology1.20757664
68MP0005174_abnormal_tail_pigmentation1.20748008
69MP0004133_heterotaxia1.19856320
70MP0000358_abnormal_cell_content/1.19784718
71MP0000566_synostosis1.19703391
72MP0005025_abnormal_response_to1.19068206
73MP0000689_abnormal_spleen_morphology1.18615220
74MP0002095_abnormal_skin_pigmentation1.17685481
75MP0002160_abnormal_reproductive_system1.15247380
76MP0002429_abnormal_blood_cell1.15194663
77MP0008260_abnormal_autophagy1.15059681
78MP0001293_anophthalmia1.14566598
79MP0009046_muscle_twitch1.13348799
80MP0005000_abnormal_immune_tolerance1.13312922
81MP0001986_abnormal_taste_sensitivity1.11845882
82MP0002420_abnormal_adaptive_immunity1.11530509
83MP0000858_altered_metastatic_potential1.11155141
84MP0005253_abnormal_eye_physiology1.11063627
85MP0000372_irregular_coat_pigmentation1.10663800
86MP0001819_abnormal_immune_cell1.10312505
87MP0000350_abnormal_cell_proliferation1.10021091
88MP0005332_abnormal_amino_acid1.09631824
89MP0003121_genomic_imprinting1.09577619
90MP0002723_abnormal_immune_serum1.09499314
91MP0008995_early_reproductive_senescence1.09046482
92MP0005084_abnormal_gallbladder_morpholo1.08537977
93MP0000631_abnormal_neuroendocrine_gland1.08192285
94MP0000015_abnormal_ear_pigmentation1.07902773
95MP0000716_abnormal_immune_system1.07634304
96MP0008877_abnormal_DNA_methylation1.05916648
97MP0005636_abnormal_mineral_homeostasis1.05895698
98MP0001984_abnormal_olfaction1.04316593
99MP0002452_abnormal_antigen_presenting1.03563576
100MP0004782_abnormal_surfactant_physiolog1.03424319
101MP0002405_respiratory_system_inflammati1.03234024
102MP0000703_abnormal_thymus_morphology1.02706379
103MP0003123_paternal_imprinting1.02500403
104MP0003646_muscle_fatigue1.02320226
105MP0005389_reproductive_system_phenotype1.01448263
106MP0003315_abnormal_perineum_morphology1.00667695
107MP0002210_abnormal_sex_determination0.98919250
108MP0005499_abnormal_olfactory_system0.98844604
109MP0005394_taste/olfaction_phenotype0.98844604
110MP0001853_heart_inflammation0.98488123
111MP0001800_abnormal_humoral_immune0.97071355
112MP0002234_abnormal_pharynx_morphology0.95036158
113MP0001730_embryonic_growth_arrest0.93072526
114MP0000049_abnormal_middle_ear0.92835709
115MP0002419_abnormal_innate_immunity0.92307537
116MP0005410_abnormal_fertilization0.90920302
117MP0003880_abnormal_central_pattern0.86811814
118MP0005670_abnormal_white_adipose0.86320818
119MP0004808_abnormal_hematopoietic_stem0.85943492
120MP0006276_abnormal_autonomic_nervous0.85939441
121MP0009745_abnormal_behavioral_response0.85169658
122MP0002163_abnormal_gland_morphology0.84756187
123MP0003567_abnormal_fetal_cardiomyocyte0.83729101
124MP0001873_stomach_inflammation0.83639758
125MP0001919_abnormal_reproductive_system0.83421153
126MP0005451_abnormal_body_composition0.83385549
127MP0008469_abnormal_protein_level0.83309667
128MP0001145_abnormal_male_reproductive0.83241753
129MP0003941_abnormal_skin_development0.83205308
130MP0010030_abnormal_orbit_morphology0.81339645
131MP0001663_abnormal_digestive_system0.81055754
132MP0001845_abnormal_inflammatory_respons0.80491940
133MP0001542_abnormal_bone_strength0.79617974
134MP0004742_abnormal_vestibular_system0.78804079
135MP0001929_abnormal_gametogenesis0.78635984
136MP0010155_abnormal_intestine_physiology0.76728385
137MP0002080_prenatal_lethality0.76669295
138MP0002751_abnormal_autonomic_nervous0.76644229
139MP0002638_abnormal_pupillary_reflex0.76375388
140MP0002272_abnormal_nervous_system0.76249964
141MP0001119_abnormal_female_reproductive0.74190045
142MP0002822_catalepsy0.73985741
143MP0005408_hypopigmentation0.71896949
144MP0001697_abnormal_embryo_size0.71151993
145MP0003698_abnormal_male_reproductive0.70728873
146MP0000653_abnormal_sex_gland0.69253962
147MP0000613_abnormal_salivary_gland0.69047289
148MP0005266_abnormal_metabolism0.68391881
149MP0002735_abnormal_chemical_nociception0.67109278
150MP0005195_abnormal_posterior_eye0.66371933
151MP0005220_abnormal_exocrine_pancreas0.59698741
152MP0003137_abnormal_impulse_conducting0.59638636
153MP0004043_abnormal_pH_regulation0.57467616
154MP0005085_abnormal_gallbladder_physiolo0.55723486
155MP0003252_abnormal_bile_duct0.54293731

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.63437858
2Abnormal number of erythroid precursors (HP:0012131)5.50467194
3Reticulocytopenia (HP:0001896)4.73452614
4Mitochondrial inheritance (HP:0001427)4.46445107
5Decreased activity of mitochondrial respiratory chain (HP:0008972)4.46065265
6Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.46065265
7Acute necrotizing encephalopathy (HP:0006965)4.43337425
8Hepatocellular necrosis (HP:0001404)4.30102773
9Abnormal mitochondria in muscle tissue (HP:0008316)4.19849048
10Increased hepatocellular lipid droplets (HP:0006565)4.16912617
11Increased CSF lactate (HP:0002490)4.01725394
12Hepatic necrosis (HP:0002605)3.98157641
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.96291034
14Birth length less than 3rd percentile (HP:0003561)3.79236242
15Lipid accumulation in hepatocytes (HP:0006561)3.77390157
16Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.65249876
173-Methylglutaconic aciduria (HP:0003535)3.64587865
18Aplastic anemia (HP:0001915)3.64159748
19Abnormality of the heme biosynthetic pathway (HP:0010472)3.64120335
20Increased serum lactate (HP:0002151)3.62183802
21Pallor (HP:0000980)3.61925078
22Type I transferrin isoform profile (HP:0003642)3.59275203
23Macrocytic anemia (HP:0001972)3.58898704
24Acute encephalopathy (HP:0006846)3.56925573
25Progressive macrocephaly (HP:0004481)3.51264111
26Increased intramyocellular lipid droplets (HP:0012240)3.49905360
27Exertional dyspnea (HP:0002875)3.49495937
28Aplasia/Hypoplasia of the sacrum (HP:0008517)3.41089704
29Renal Fanconi syndrome (HP:0001994)3.40595458
30Oral leukoplakia (HP:0002745)3.13283270
31Increased muscle lipid content (HP:0009058)3.01429153
32Lactic acidosis (HP:0003128)3.00901883
33Reduced antithrombin III activity (HP:0001976)3.00628345
34Exercise intolerance (HP:0003546)2.99336406
35Breast hypoplasia (HP:0003187)2.90168920
36Respiratory difficulties (HP:0002880)2.85076708
37Rough bone trabeculation (HP:0100670)2.75515908
38Microvesicular hepatic steatosis (HP:0001414)2.70477125
39Poor head control (HP:0002421)2.69575858
40Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.69021197
41Abnormal protein N-linked glycosylation (HP:0012347)2.69021197
42Abnormal protein glycosylation (HP:0012346)2.69021197
43Abnormal glycosylation (HP:0012345)2.69021197
44Pancreatic cysts (HP:0001737)2.66196213
45Lethargy (HP:0001254)2.66046348
46Microretrognathia (HP:0000308)2.65441549
47Methylmalonic aciduria (HP:0012120)2.65125282
48Methylmalonic acidemia (HP:0002912)2.62356681
49Respiratory failure (HP:0002878)2.62314453
50Abnormality of midbrain morphology (HP:0002418)2.57389962
51Molar tooth sign on MRI (HP:0002419)2.57389962
5211 pairs of ribs (HP:0000878)2.51724465
53Pancreatic fibrosis (HP:0100732)2.50994301
54Hyperglycinemia (HP:0002154)2.50461276
55Cerebral edema (HP:0002181)2.34312167
56Petechiae (HP:0000967)2.33492398
57True hermaphroditism (HP:0010459)2.32450073
58Colon cancer (HP:0003003)2.32242470
59Pancytopenia (HP:0001876)2.32201472
60Abnormality of the preputium (HP:0100587)2.30363040
61Degeneration of anterior horn cells (HP:0002398)2.27149807
62Abnormality of the anterior horn cell (HP:0006802)2.27149807
63Cerebral hypomyelination (HP:0006808)2.26906982
64Premature graying of hair (HP:0002216)2.20047601
65Abnormality of serum amino acid levels (HP:0003112)2.19978706
66Dicarboxylic aciduria (HP:0003215)2.19742781
67Abnormality of dicarboxylic acid metabolism (HP:0010995)2.19742781
68Abnormality of renal resorption (HP:0011038)2.15987487
69Secondary amenorrhea (HP:0000869)2.15854409
70IgM deficiency (HP:0002850)2.15421077
71Congenital, generalized hypertrichosis (HP:0004540)2.14877211
72Optic disc pallor (HP:0000543)2.12488422
73Absent thumb (HP:0009777)2.11237711
74Bone marrow hypocellularity (HP:0005528)2.07418710
75Progressive microcephaly (HP:0000253)2.07103201
76CNS demyelination (HP:0007305)2.06317056
77Carpal bone hypoplasia (HP:0001498)2.05250801
78Chromsome breakage (HP:0040012)2.05022106
79Medial flaring of the eyebrow (HP:0010747)2.04172284
80Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.03888433
81Abnormality of alanine metabolism (HP:0010916)2.03888433
82Hyperalaninemia (HP:0003348)2.03888433
83Congenital stationary night blindness (HP:0007642)2.01716793
84Meckel diverticulum (HP:0002245)2.00026755
85Abnormality of reticulocytes (HP:0004312)1.99727734
86Type 2 muscle fiber atrophy (HP:0003554)1.99383589
87Thrombocytosis (HP:0001894)1.98634170
88Severe visual impairment (HP:0001141)1.97989743
89Progressive muscle weakness (HP:0003323)1.97126402
90Abnormal trabecular bone morphology (HP:0100671)1.94340844
91Chromosomal breakage induced by crosslinking agents (HP:0003221)1.94316720
92Muscle fiber atrophy (HP:0100295)1.93391555
93Nephronophthisis (HP:0000090)1.93278172
94Triphalangeal thumb (HP:0001199)1.92680174
95Abnormality of the ileum (HP:0001549)1.90544060
96Hyperglycinuria (HP:0003108)1.89898265
97Abnormal spermatogenesis (HP:0008669)1.88140883
98Sparse eyelashes (HP:0000653)1.87228700
99Testicular atrophy (HP:0000029)1.85533557
100Trismus (HP:0000211)1.84858806
101Abnormality of chromosome stability (HP:0003220)1.84632995
102Pulmonary fibrosis (HP:0002206)1.84040898
103Sclerocornea (HP:0000647)1.83637845
104Absent rod-and cone-mediated responses on ERG (HP:0007688)1.83125312
105Hypoplasia of the pons (HP:0012110)1.82970205
106Decreased electroretinogram (ERG) amplitude (HP:0000654)1.82668997
107Glycosuria (HP:0003076)1.82593014
108Abnormality of urine glucose concentration (HP:0011016)1.82593014
109Cleft eyelid (HP:0000625)1.82306514
110Nausea (HP:0002018)1.82248682
111Patellar aplasia (HP:0006443)1.81739236
112Type II lissencephaly (HP:0007260)1.81212917
113Abnormality of glycine metabolism (HP:0010895)1.79462698
114Abnormality of serine family amino acid metabolism (HP:0010894)1.79462698
115X-linked dominant inheritance (HP:0001423)1.77537220
116Hyperphosphaturia (HP:0003109)1.77474903
117Aplasia/hypoplasia of the uterus (HP:0008684)1.76608397
118Aplasia/Hypoplasia of the patella (HP:0006498)1.76065176
119Abnormality of glycolysis (HP:0004366)1.76023099
120Increased serum pyruvate (HP:0003542)1.76023099
121Emotional lability (HP:0000712)1.75825970
122Irregular epiphyses (HP:0010582)1.75675661
123Abnormal rod and cone electroretinograms (HP:0008323)1.75604537
124Abnormality of the pons (HP:0007361)1.74199971
125Pendular nystagmus (HP:0012043)1.73082216
126Abolished electroretinogram (ERG) (HP:0000550)1.73072714
127Generalized aminoaciduria (HP:0002909)1.71556479
128Aplasia/Hypoplasia of the uvula (HP:0010293)1.71155894
129Cellular immunodeficiency (HP:0005374)1.70805917
130Leukodystrophy (HP:0002415)1.68414845
131Male pseudohermaphroditism (HP:0000037)1.66991407
132Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.65688314
133Ketosis (HP:0001946)1.63960856
134Abnormality of aspartate family amino acid metabolism (HP:0010899)1.61880566
135Hypothermia (HP:0002045)1.59979334

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.10956185
2BUB15.00738815
3NME24.71701911
4STK164.65961261
5EIF2AK13.55255498
6TLK12.73140469
7WEE12.70822322
8NUAK12.55077430
9SRPK12.43322517
10VRK12.39640558
11EIF2AK32.32928966
12TESK22.12277948
13PIM22.06855944
14NME12.06846324
15PLK41.96789532
16WNK31.70202040
17IRAK31.67144429
18GRK11.63442530
19MAP4K21.62193874
20DYRK31.62139927
21FRK1.60544251
22ACVR1B1.55491235
23BRSK21.49504084
24IRAK41.43088223
25BCKDK1.42788627
26TAF11.41107752
27ZAK1.37387691
28PBK1.33795634
29MAP3K111.32584036
30NEK11.32340843
31CDC71.32221859
32KDR1.31256787
33MAP3K121.29638336
34CDK81.28626194
35RPS6KA41.28099313
36INSRR1.25194395
37BLK1.25085411
38PLK11.22173597
39MST41.21083228
40CDK191.21007072
41BRAF1.15982539
42MAP4K11.15024333
43AURKB1.14400249
44TTK1.13921045
45MKNK11.12498893
46TESK11.11076301
47CSNK1G31.09914318
48NEK21.09506759
49MKNK21.08729952
50AURKA1.07353210
51TSSK61.03859035
52TEC1.02704307
53CCNB11.01038196
54TXK1.00819338
55WNK40.98967265
56TRIM280.97777179
57PIK3CG0.97631073
58EIF2AK20.94503718
59CSNK1G20.93445114
60CSNK1G10.88000140
61PDK20.86377750
62ATR0.86199273
63SCYL20.82056959
64RPS6KB20.80731335
65OXSR10.79691710
66CHEK20.76481028
67CDK70.76458348
68FLT30.75189019
69ZAP700.72024720
70PINK10.71810209
71BRSK10.70941843
72CSNK2A10.69511213
73ARAF0.69504749
74DYRK20.69436831
75ABL20.68187254
76PASK0.68153873
77CSNK1A1L0.68013504
78PLK30.67822452
79IRAK10.66269775
80NEK90.64887198
81PIM10.64317015
82EPHA20.62247444
83CLK10.61221566
84MAPK130.61077514
85PRKCG0.60386648
86OBSCN0.58936395
87CAMKK20.58758178
88NLK0.58749603
89CSNK2A20.57447332
90TIE10.57409620
91IKBKB0.57080000
92MAPKAPK50.56589062
93ADRBK20.55976719
94BTK0.55444365
95LIMK10.54326398
96STK390.51582677
97SYK0.51427991
98PIK3CA0.51080054
99TAOK30.50928660
100MYLK0.50022483
101RPS6KA50.49628981
102LYN0.49086046
103YES10.48697484
104CDK40.48267676
105ILK0.48018539
106MUSK0.47640317
107MAPKAPK30.47101358
108STK40.45597799
109TBK10.45560611
110PHKG10.45518367
111PHKG20.45518367
112ADRBK10.45197641
113CSNK1A10.44873981
114ATM0.44655469
115PAK10.42588113
116MAP3K80.41776333
117DAPK30.39865859
118STK38L0.39724760
119PRKCQ0.39368897
120TNIK0.39041634
121BMPR20.38068558
122CSNK1E0.37782007
123TAOK20.37286028
124BMPR1B0.37112860
125MAP2K70.36621225
126KIT0.35920503
127PRKCI0.35789830
128PAK40.35765095
129MAP3K140.34287529
130IKBKE0.33637763
131MAP2K60.31870079
132DAPK10.31751583

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.11859939
2Proteasome_Homo sapiens_hsa030504.35694433
3DNA replication_Homo sapiens_hsa030303.95645728
4RNA polymerase_Homo sapiens_hsa030203.62478119
5Mismatch repair_Homo sapiens_hsa034303.16617462
6Protein export_Homo sapiens_hsa030603.03213483
7Oxidative phosphorylation_Homo sapiens_hsa001902.94914631
8Pyrimidine metabolism_Homo sapiens_hsa002402.79344025
9Parkinsons disease_Homo sapiens_hsa050122.70793729
10Homologous recombination_Homo sapiens_hsa034402.69918122
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.61994142
12Spliceosome_Homo sapiens_hsa030402.50407978
13Base excision repair_Homo sapiens_hsa034102.45308871
14Nucleotide excision repair_Homo sapiens_hsa034202.30775067
15Huntingtons disease_Homo sapiens_hsa050162.14097980
16RNA transport_Homo sapiens_hsa030131.89179977
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.88193076
18Folate biosynthesis_Homo sapiens_hsa007901.76378959
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.74273858
20Alzheimers disease_Homo sapiens_hsa050101.72730543
21Fanconi anemia pathway_Homo sapiens_hsa034601.70125598
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.63074141
23One carbon pool by folate_Homo sapiens_hsa006701.61925132
24Basal transcription factors_Homo sapiens_hsa030221.60122415
25RNA degradation_Homo sapiens_hsa030181.58475012
26Purine metabolism_Homo sapiens_hsa002301.51841458
27Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.50132759
28Cell cycle_Homo sapiens_hsa041101.46407562
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.45220476
30Non-homologous end-joining_Homo sapiens_hsa034501.44612893
31Sulfur relay system_Homo sapiens_hsa041221.43492947
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.39603694
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.34176885
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28417345
35Fatty acid elongation_Homo sapiens_hsa000621.12736303
36Propanoate metabolism_Homo sapiens_hsa006401.08107896
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04805432
38Phototransduction_Homo sapiens_hsa047441.00245396
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97157268
40p53 signaling pathway_Homo sapiens_hsa041150.95521427
41Butanoate metabolism_Homo sapiens_hsa006500.93530497
42Pentose phosphate pathway_Homo sapiens_hsa000300.89171893
43SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84046888
44Epstein-Barr virus infection_Homo sapiens_hsa051690.83746126
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79968407
46Glutathione metabolism_Homo sapiens_hsa004800.77675834
47Chemical carcinogenesis_Homo sapiens_hsa052040.76164038
48Legionellosis_Homo sapiens_hsa051340.74243722
49Drug metabolism - other enzymes_Homo sapiens_hsa009830.73494958
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.71532243
51Tryptophan metabolism_Homo sapiens_hsa003800.71454646
52Systemic lupus erythematosus_Homo sapiens_hsa053220.69239344
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69002052
54Cardiac muscle contraction_Homo sapiens_hsa042600.68296513
55Metabolic pathways_Homo sapiens_hsa011000.67831323
56Primary immunodeficiency_Homo sapiens_hsa053400.67010976
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65747527
58Collecting duct acid secretion_Homo sapiens_hsa049660.65345742
59N-Glycan biosynthesis_Homo sapiens_hsa005100.65298152
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.65123947
61Antigen processing and presentation_Homo sapiens_hsa046120.63070218
62Nitrogen metabolism_Homo sapiens_hsa009100.62874656
63Caffeine metabolism_Homo sapiens_hsa002320.60980895
64Other glycan degradation_Homo sapiens_hsa005110.60739303
65Regulation of autophagy_Homo sapiens_hsa041400.60688813
66Retinol metabolism_Homo sapiens_hsa008300.59338722
67Galactose metabolism_Homo sapiens_hsa000520.59276779
68Fatty acid degradation_Homo sapiens_hsa000710.58854911
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58220046
702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.57595451
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57237936
72Herpes simplex infection_Homo sapiens_hsa051680.55515638
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54965535
74Arachidonic acid metabolism_Homo sapiens_hsa005900.54304449
75Graft-versus-host disease_Homo sapiens_hsa053320.53885269
76Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53768542
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.53684697
78Vitamin B6 metabolism_Homo sapiens_hsa007500.52820072
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51116335
80mRNA surveillance pathway_Homo sapiens_hsa030150.50884144
81Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49426748
82Fructose and mannose metabolism_Homo sapiens_hsa000510.48387175
83Tyrosine metabolism_Homo sapiens_hsa003500.48379478
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.48243040
85Fatty acid metabolism_Homo sapiens_hsa012120.46071135
86Vitamin digestion and absorption_Homo sapiens_hsa049770.45900394
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43571577
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42106923
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41416143
90Hematopoietic cell lineage_Homo sapiens_hsa046400.40282601
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39035557
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.38979766
93Allograft rejection_Homo sapiens_hsa053300.38950434
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37837186
95Selenocompound metabolism_Homo sapiens_hsa004500.36825982
96Type I diabetes mellitus_Homo sapiens_hsa049400.36434235
97Steroid biosynthesis_Homo sapiens_hsa001000.36337925
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36301632
99Asthma_Homo sapiens_hsa053100.36129916
100beta-Alanine metabolism_Homo sapiens_hsa004100.36104485
101Ether lipid metabolism_Homo sapiens_hsa005650.33787133
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.33053003
103Fat digestion and absorption_Homo sapiens_hsa049750.32747768
104Carbon metabolism_Homo sapiens_hsa012000.32261387
105Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30780406
106Apoptosis_Homo sapiens_hsa042100.28402397
107Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.27738003
108NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27392690
109Sphingolipid metabolism_Homo sapiens_hsa006000.27065583
110Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26862107
111Autoimmune thyroid disease_Homo sapiens_hsa053200.26674517
112Vibrio cholerae infection_Homo sapiens_hsa051100.25239939
113Measles_Homo sapiens_hsa051620.23493596
114Biosynthesis of amino acids_Homo sapiens_hsa012300.23028149
115Shigellosis_Homo sapiens_hsa051310.22791863
116Arginine and proline metabolism_Homo sapiens_hsa003300.21305921
117Viral carcinogenesis_Homo sapiens_hsa052030.21222418
118Thyroid cancer_Homo sapiens_hsa052160.20855762
119Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20423093
120NF-kappa B signaling pathway_Homo sapiens_hsa040640.20321964
121Rheumatoid arthritis_Homo sapiens_hsa053230.20185629
122Linoleic acid metabolism_Homo sapiens_hsa005910.20062176
123Pentose and glucuronate interconversions_Homo sapiens_hsa000400.19935968
124Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.19700015
125HTLV-I infection_Homo sapiens_hsa051660.19113724
126Maturity onset diabetes of the young_Homo sapiens_hsa049500.18231360
127Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.17996806
128Sulfur metabolism_Homo sapiens_hsa009200.17700088
129Leishmaniasis_Homo sapiens_hsa051400.14777337
130Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.13416977
131Peroxisome_Homo sapiens_hsa041460.13042905
132Pertussis_Homo sapiens_hsa051330.12415054
133Oocyte meiosis_Homo sapiens_hsa041140.12165622
134Pyruvate metabolism_Homo sapiens_hsa006200.10909163
135Hepatitis B_Homo sapiens_hsa051610.10754451

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »