MRPS10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S10P family. Pseudogenes corresponding to this gene are found on chromosomes 1q, 3p, and 9p. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.27732703
2proteasome assembly (GO:0043248)4.98577055
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.94625768
4ribosomal small subunit assembly (GO:0000028)4.82717554
5establishment of integrated proviral latency (GO:0075713)4.59094904
6maturation of SSU-rRNA (GO:0030490)4.52148123
7ribosomal large subunit biogenesis (GO:0042273)4.26661667
8telomere maintenance via semi-conservative replication (GO:0032201)4.22374358
9rRNA modification (GO:0000154)4.20748526
10establishment of protein localization to mitochondrial membrane (GO:0090151)4.19538632
11chaperone-mediated protein transport (GO:0072321)4.16111844
12ATP synthesis coupled proton transport (GO:0015986)4.13959988
13energy coupled proton transport, down electrochemical gradient (GO:0015985)4.13959988
14deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.10321111
15purine nucleobase biosynthetic process (GO:0009113)4.06020462
16nucleobase biosynthetic process (GO:0046112)4.02598991
17regulation of mitochondrial translation (GO:0070129)3.97697897
18ribonucleoprotein complex biogenesis (GO:0022613)3.97141905
19DNA strand elongation involved in DNA replication (GO:0006271)3.96034990
20ribosome biogenesis (GO:0042254)3.95425933
21pseudouridine synthesis (GO:0001522)3.93891865
22protein deneddylation (GO:0000338)3.92714613
23mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.90291965
24tRNA methylation (GO:0030488)3.89322971
25ribosomal small subunit biogenesis (GO:0042274)3.88409986
26negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.87809286
27DNA strand elongation (GO:0022616)3.81020364
28transcription elongation from RNA polymerase III promoter (GO:0006385)3.78942690
29termination of RNA polymerase III transcription (GO:0006386)3.78942690
30CENP-A containing nucleosome assembly (GO:0034080)3.77979645
31telomere maintenance via recombination (GO:0000722)3.77440260
32chromatin remodeling at centromere (GO:0031055)3.75480379
33spliceosomal snRNP assembly (GO:0000387)3.75274847
34establishment of viral latency (GO:0019043)3.70525722
35DNA replication initiation (GO:0006270)3.67454634
36positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.64851916
37respiratory electron transport chain (GO:0022904)3.62986833
38regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.61526109
39rRNA processing (GO:0006364)3.60560782
40anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.57786160
41viral transcription (GO:0019083)3.57409567
42electron transport chain (GO:0022900)3.55554324
43telomere maintenance via telomere lengthening (GO:0010833)3.54197691
44mitochondrial respiratory chain complex assembly (GO:0033108)3.53544844
45ribosome assembly (GO:0042255)3.51630783
46protein complex biogenesis (GO:0070271)3.51226405
47negative regulation of ligase activity (GO:0051352)3.50675015
48negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.50675015
49translational termination (GO:0006415)3.50539488
50kinetochore assembly (GO:0051382)3.49661706
51DNA double-strand break processing (GO:0000729)3.49425821
52DNA replication checkpoint (GO:0000076)3.49173496
53formation of translation preinitiation complex (GO:0001731)3.47603205
54protein neddylation (GO:0045116)3.47438967
55rRNA metabolic process (GO:0016072)3.46618649
56cellular component biogenesis (GO:0044085)3.46522641
57mitotic recombination (GO:0006312)3.45489596
58regulation of nuclear cell cycle DNA replication (GO:0033262)3.43639263
59mitotic metaphase plate congression (GO:0007080)3.41814503
60regulation of cellular amino acid metabolic process (GO:0006521)3.40776014
61regulation of ubiquitin-protein transferase activity (GO:0051438)3.39696225
62histone exchange (GO:0043486)3.37634063
63rRNA methylation (GO:0031167)3.36059829
64L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.35008566
65DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.34630335
66protein targeting to mitochondrion (GO:0006626)3.33269036
67signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.33153945
68signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.33153945
69signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.33153945
70mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.30903408
71mitochondrial respiratory chain complex I assembly (GO:0032981)3.30903408
72NADH dehydrogenase complex assembly (GO:0010257)3.30903408
73kinetochore organization (GO:0051383)3.30665060
74signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.29247443
75intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.29247443
76DNA ligation (GO:0006266)3.28318845
77translation (GO:0006412)3.28076650
78regulation of ligase activity (GO:0051340)3.27686036
79translational elongation (GO:0006414)3.27441198
80antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.26200335
81DNA catabolic process, exonucleolytic (GO:0000738)3.25523552
82signal transduction involved in DNA integrity checkpoint (GO:0072401)3.24862360
83signal transduction involved in DNA damage checkpoint (GO:0072422)3.24862360
84transcription-coupled nucleotide-excision repair (GO:0006283)3.24264722
857-methylguanosine mRNA capping (GO:0006370)3.23756682
86SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.22572636
87signal transduction involved in cell cycle checkpoint (GO:0072395)3.21438859
88deoxyribonucleotide biosynthetic process (GO:0009263)3.21330168
89maturation of 5.8S rRNA (GO:0000460)3.19479324
907-methylguanosine RNA capping (GO:0009452)3.19233146
91RNA capping (GO:0036260)3.19233146
92DNA replication-independent nucleosome organization (GO:0034724)3.18653943
93DNA replication-independent nucleosome assembly (GO:0006336)3.18653943
94transcription from RNA polymerase I promoter (GO:0006360)3.17784820
95positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.16605953
96protein localization to kinetochore (GO:0034501)3.15791805
97translational initiation (GO:0006413)3.14372989
98IMP biosynthetic process (GO:0006188)3.14107092
99L-methionine salvage (GO:0071267)3.13962569
100L-methionine biosynthetic process (GO:0071265)3.13962569
101amino acid salvage (GO:0043102)3.13962569
102cotranslational protein targeting to membrane (GO:0006613)3.12328172
103regulation of mitotic spindle checkpoint (GO:1903504)3.12102087
104regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.12102087
105termination of RNA polymerase I transcription (GO:0006363)3.11281471
106exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.10729758
107folic acid metabolic process (GO:0046655)3.09832766
108protein targeting to ER (GO:0045047)3.09504589
109transcription elongation from RNA polymerase I promoter (GO:0006362)3.09019965
110replication fork processing (GO:0031297)3.08540679
1112-deoxyribonucleotide biosynthetic process (GO:0009265)3.07460785
112deoxyribose phosphate biosynthetic process (GO:0046385)3.07460785
113tRNA modification (GO:0006400)3.05851073
114positive regulation of ligase activity (GO:0051351)3.05460345
115protein localization to mitochondrion (GO:0070585)3.04814427
116antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.02908006
117tRNA aminoacylation (GO:0043039)3.02279698
118amino acid activation (GO:0043038)3.02279698
119nucleotide-excision repair, DNA gap filling (GO:0006297)3.02233625
120establishment of protein localization to mitochondrion (GO:0072655)3.01542525
121cell cycle G1/S phase transition (GO:0044843)3.01055733
122G1/S transition of mitotic cell cycle (GO:0000082)3.01055733
123cytochrome complex assembly (GO:0017004)3.00645637
124protein K6-linked ubiquitination (GO:0085020)3.00617776
125respiratory chain complex IV assembly (GO:0008535)2.99864389
126oxidative phosphorylation (GO:0006119)2.99562066
127tRNA aminoacylation for protein translation (GO:0006418)2.99396521
128protein localization to endoplasmic reticulum (GO:0070972)2.99292890
129spindle checkpoint (GO:0031577)2.99100774
130metaphase plate congression (GO:0051310)2.98110378
131negative regulation of protein ubiquitination (GO:0031397)2.98017623
132deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.94923745
133DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.94921625
134ncRNA processing (GO:0034470)2.93842183
135IMP metabolic process (GO:0046040)2.93206468
136nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.93011152
137organelle disassembly (GO:1903008)2.91650277
138DNA damage response, detection of DNA damage (GO:0042769)2.90332420
139mitotic spindle checkpoint (GO:0071174)2.89911205
140water-soluble vitamin biosynthetic process (GO:0042364)2.89258780
141ncRNA metabolic process (GO:0034660)2.88870579
142RNA methylation (GO:0001510)2.88378224
143establishment of protein localization to endoplasmic reticulum (GO:0072599)2.87976736
144tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.87757367
145RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.87757367
146inner mitochondrial membrane organization (GO:0007007)2.87085809
147cullin deneddylation (GO:0010388)2.84580442

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.84403682
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.57640184
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.41987821
4* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.94593862
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.65124739
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.59631357
7* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.58077210
8* ETS1_20019798_ChIP-Seq_JURKAT_Human3.40173791
9MYC_18358816_ChIP-ChIP_MESCs_Mouse3.27948287
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.23214431
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.02444575
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.01652172
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.95887100
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.91745080
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.90815619
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.89766575
17* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.69692960
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.67843397
19* VDR_23849224_ChIP-Seq_CD4+_Human2.57222233
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.56256123
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.49364768
22E2F1_18555785_ChIP-Seq_MESCs_Mouse2.42428657
23DCP1A_22483619_ChIP-Seq_HELA_Human2.33573677
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.31602532
25XRN2_22483619_ChIP-Seq_HELA_Human2.29637207
26SRF_21415370_ChIP-Seq_HL-1_Mouse2.27201590
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25977165
28FOXM1_23109430_ChIP-Seq_U2OS_Human2.24701321
29THAP11_20581084_ChIP-Seq_MESCs_Mouse2.23107782
30FOXP3_21729870_ChIP-Seq_TREG_Human2.21658456
31YY1_21170310_ChIP-Seq_MESCs_Mouse2.19342432
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.15991021
33* GABP_19822575_ChIP-Seq_HepG2_Human1.97173843
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.95306894
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.95075544
36TTF2_22483619_ChIP-Seq_HELA_Human1.93878988
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.83411876
38ELK1_19687146_ChIP-ChIP_HELA_Human1.81772409
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81474038
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.79385817
41ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.78723997
42* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75969885
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.69634193
44MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.67125830
45MYCN_18555785_ChIP-Seq_MESCs_Mouse1.65922379
46* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.62654152
47SALL1_21062744_ChIP-ChIP_HESCs_Human1.59814978
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59584553
49* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.59131124
50* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58790986
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.58477100
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57837876
53AR_21909140_ChIP-Seq_LNCAP_Human1.53596110
54E2F1_21310950_ChIP-Seq_MCF-7_Human1.45466223
55CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.43652030
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41912281
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.40007777
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.37877918
59VDR_22108803_ChIP-Seq_LS180_Human1.36997678
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.36382306
61CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.33300661
62EWS_26573619_Chip-Seq_HEK293_Human1.31085695
63CIITA_25753668_ChIP-Seq_RAJI_Human1.30826277
64KDM5A_27292631_Chip-Seq_BREAST_Human1.29726519
65FLI1_27457419_Chip-Seq_LIVER_Mouse1.28082635
66* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.24451659
67SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.24201879
68MYC_18940864_ChIP-ChIP_HL60_Human1.22709749
69BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.21766180
70TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.21579300
71ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.21135580
72IRF1_19129219_ChIP-ChIP_H3396_Human1.20863535
73FUS_26573619_Chip-Seq_HEK293_Human1.20551508
74CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.19073011
75HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16109593
76ZNF274_21170338_ChIP-Seq_K562_Hela1.15688738
77EGR1_23403033_ChIP-Seq_LIVER_Mouse1.13735256
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13698128
79CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09514503
80RBPJ_22232070_ChIP-Seq_NCS_Mouse1.07984440
81ELK1_22589737_ChIP-Seq_MCF10A_Human1.07223363
82STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06588446
83SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04854639
84POU3F2_20337985_ChIP-ChIP_501MEL_Human1.03664608
85* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03292661
86CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99799137
87POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.98577642
88NANOG_16153702_ChIP-ChIP_HESCs_Human0.97441528
89SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.96738467
90KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.95982643
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95824870
92PCGF2_27294783_Chip-Seq_ESCs_Mouse0.93270748
93* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93219884
94* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92748364
95FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.90898324
96ELF5_23300383_ChIP-Seq_T47D_Human0.90244387
97SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89322990
98RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.85843185
99HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.85361877
100TP63_19390658_ChIP-ChIP_HaCaT_Human0.83709881
101TFEB_21752829_ChIP-Seq_HELA_Human0.83266451
102SRY_22984422_ChIP-ChIP_TESTIS_Rat0.83078600
103SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.82157124
104NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.80944142
105* SOX17_20123909_ChIP-Seq_XEN_Mouse0.80844233
106DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.80644860
107CTCF_18555785_ChIP-Seq_MESCs_Mouse0.80036014
108* SPI1_23547873_ChIP-Seq_NB4_Human0.78346041
109* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.76563296
110CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.75267884
111CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.74606755
112OCT4_18692474_ChIP-Seq_MEFs_Mouse0.74003040
113TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.73946967
114TBX5_21415370_ChIP-Seq_HL-1_Mouse0.73921557
115KLF4_18555785_ChIP-Seq_MESCs_Mouse0.73529959
116YY1_22570637_ChIP-Seq_MALME-3M_Human0.73274455
117IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.72259371
118ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.70473674
119EZH2_27294783_Chip-Seq_NPCs_Mouse0.70384022
120ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.69037136
121IGF1R_20145208_ChIP-Seq_DFB_Human0.68310774
122SOX2_16153702_ChIP-ChIP_HESCs_Human0.65048723
123HTT_18923047_ChIP-ChIP_STHdh_Human0.64421118
124EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.64279578
125SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.62689314

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.61471187
2MP0003111_abnormal_nucleus_morphology4.20404011
3MP0008058_abnormal_DNA_repair3.70593678
4MP0010094_abnormal_chromosome_stability3.65508797
5MP0004957_abnormal_blastocyst_morpholog3.51545585
6MP0003077_abnormal_cell_cycle3.06136103
7MP0003806_abnormal_nucleotide_metabolis3.04559318
8MP0006292_abnormal_olfactory_placode2.99441711
9MP0008007_abnormal_cellular_replicative2.65374369
10MP0008057_abnormal_DNA_replication2.63823112
11MP0003718_maternal_effect2.61648633
12MP0008932_abnormal_embryonic_tissue2.52872973
13MP0003786_premature_aging2.46511622
14MP0009697_abnormal_copulation2.46366590
15MP0000372_irregular_coat_pigmentation2.23732405
16MP0003186_abnormal_redox_activity2.16011547
17MP0009379_abnormal_foot_pigmentation2.06965989
18MP0003950_abnormal_plasma_membrane2.05929018
19MP0002396_abnormal_hematopoietic_system1.99856104
20MP0002837_dystrophic_cardiac_calcinosis1.96742378
21MP0006036_abnormal_mitochondrial_physio1.93427137
22MP0002132_abnormal_respiratory_system1.93249731
23MP0000490_abnormal_crypts_of1.89836848
24MP0005408_hypopigmentation1.84637606
25MP0003941_abnormal_skin_development1.83092197
26MP0001986_abnormal_taste_sensitivity1.74318631
27MP0008877_abnormal_DNA_methylation1.73776335
28MP0006072_abnormal_retinal_apoptosis1.72353419
29MP0006035_abnormal_mitochondrial_morpho1.69149597
30MP0001764_abnormal_homeostasis1.68869300
31MP0003123_paternal_imprinting1.68435620
32MP0001529_abnormal_vocalization1.63570487
33MP0001188_hyperpigmentation1.61580381
34MP0000566_synostosis1.61172403
35MP0004215_abnormal_myocardial_fiber1.60421244
36MP0002139_abnormal_hepatobiliary_system1.56515790
37MP0005075_abnormal_melanosome_morpholog1.50976939
38MP0003646_muscle_fatigue1.43207415
39MP0003195_calcinosis1.38937322
40MP0010352_gastrointestinal_tract_polyps1.37152309
41MP0002102_abnormal_ear_morphology1.33203376
42MP0002160_abnormal_reproductive_system1.32091853
43MP0009333_abnormal_splenocyte_physiolog1.29357182
44MP0005085_abnormal_gallbladder_physiolo1.23874384
45MP0003890_abnormal_embryonic-extraembry1.22939380
46MP0003878_abnormal_ear_physiology1.22806690
47MP0005377_hearing/vestibular/ear_phenot1.22806690
48MP0004084_abnormal_cardiac_muscle1.20241487
49MP0008260_abnormal_autophagy1.20206721
50MP0002210_abnormal_sex_determination1.18811943
51MP0005330_cardiomyopathy1.17992606
52MP0000350_abnormal_cell_proliferation1.17977279
53MP0000647_abnormal_sebaceous_gland1.17734197
54MP0003315_abnormal_perineum_morphology1.17421193
55MP0005389_reproductive_system_phenotype1.16124214
56MP0008875_abnormal_xenobiotic_pharmacok1.15281696
57MP0000313_abnormal_cell_death1.14695680
58MP0008789_abnormal_olfactory_epithelium1.13622016
59MP0002234_abnormal_pharynx_morphology1.10066345
60MP0000858_altered_metastatic_potential1.07312926
61MP0005084_abnormal_gallbladder_morpholo1.06782425
62MP0003136_yellow_coat_color1.05043615
63MP0001919_abnormal_reproductive_system1.04886879
64MP0001853_heart_inflammation1.04738562
65MP0001119_abnormal_female_reproductive1.04534156
66MP0010030_abnormal_orbit_morphology1.03499966
67MP0002019_abnormal_tumor_incidence1.02943200
68MP0004147_increased_porphyrin_level1.02773007
69MP0005365_abnormal_bile_salt1.01195400
70MP0000749_muscle_degeneration0.99864745
71MP0001730_embryonic_growth_arrest0.98070312
72MP0002095_abnormal_skin_pigmentation0.96643767
73MP0003763_abnormal_thymus_physiology0.95839561
74MP0004133_heterotaxia0.95158290
75MP0005670_abnormal_white_adipose0.94743007
76MP0002277_abnormal_respiratory_mucosa0.94554504
77MP0001145_abnormal_male_reproductive0.93353292
78MP0000015_abnormal_ear_pigmentation0.91394502
79MP0004381_abnormal_hair_follicle0.91222642
80MP0003937_abnormal_limbs/digits/tail_de0.90915523
81MP0001293_anophthalmia0.90333520
82MP0002090_abnormal_vision0.88630512
83MP0003567_abnormal_fetal_cardiomyocyte0.88251262
84MP0005253_abnormal_eye_physiology0.87366130
85MP0001545_abnormal_hematopoietic_system0.87180736
86MP0005397_hematopoietic_system_phenotyp0.87180736
87MP0001672_abnormal_embryogenesis/_devel0.86922512
88MP0005380_embryogenesis_phenotype0.86922512
89MP0002877_abnormal_melanocyte_morpholog0.86553867
90MP0002080_prenatal_lethality0.86325909
91MP0008775_abnormal_heart_ventricle0.86142051
92MP0009785_altered_susceptibility_to0.85277216
93MP0002084_abnormal_developmental_patter0.84741442
94MP0001697_abnormal_embryo_size0.82908727
95MP0004145_abnormal_muscle_electrophysio0.81982277
96MP0000358_abnormal_cell_content/0.81317955
97MP0002085_abnormal_embryonic_tissue0.81050358
98MP0005360_urolithiasis0.80952297
99MP0004808_abnormal_hematopoietic_stem0.80743287
100MP0002269_muscular_atrophy0.80419258
101MP0000653_abnormal_sex_gland0.79208011
102MP0001727_abnormal_embryo_implantation0.79179318
103MP0004019_abnormal_vitamin_homeostasis0.74293319
104MP0005395_other_phenotype0.73009858
105MP0000751_myopathy0.72847368
106MP0002177_abnormal_outer_ear0.72497269
107MP0005174_abnormal_tail_pigmentation0.71895749
108MP0000689_abnormal_spleen_morphology0.71751802
109MP0001835_abnormal_antigen_presentation0.71490579
110MP0005266_abnormal_metabolism0.71147635
111MP0003011_delayed_dark_adaptation0.71141456
112MP0003984_embryonic_growth_retardation0.70647687
113MP0008873_increased_physiological_sensi0.70525996
114MP0002722_abnormal_immune_system0.70052157
115MP0008872_abnormal_physiological_respon0.69761735
116MP0000427_abnormal_hair_cycle0.69425208
117MP0000613_abnormal_salivary_gland0.69318486
118MP0001881_abnormal_mammary_gland0.69147559
119MP0005332_abnormal_amino_acid0.67550114
120MP0008995_early_reproductive_senescence0.67194582
121MP0002088_abnormal_embryonic_growth/wei0.66646710
122MP0002233_abnormal_nose_morphology0.65389701
123MP0001929_abnormal_gametogenesis0.64061930
124MP0001542_abnormal_bone_strength0.63518841
125MP0004036_abnormal_muscle_relaxation0.63212215
126MP0006054_spinal_hemorrhage0.62720165
127MP0001984_abnormal_olfaction0.62540231
128MP0009840_abnormal_foam_cell0.61672571
129MP0002972_abnormal_cardiac_muscle0.60995036
130MP0002938_white_spotting0.60413700
131MP0005319_abnormal_enzyme/_coenzyme0.60333615
132MP0001243_abnormal_dermal_layer0.59398189
133MP0000703_abnormal_thymus_morphology0.59066665
134MP0002429_abnormal_blood_cell0.58755773
135MP0003221_abnormal_cardiomyocyte_apopto0.58644753
136MP0000516_abnormal_urinary_system0.58563490
137MP0005367_renal/urinary_system_phenotyp0.58563490
138MP0001661_extended_life_span0.58498134
139MP0003938_abnormal_ear_development0.58435762
140MP0001299_abnormal_eye_distance/0.58006512
141MP0005379_endocrine/exocrine_gland_phen0.57995888
142MP0001286_abnormal_eye_development0.57182680
143MP0008469_abnormal_protein_level0.56629396
144MP0005165_increased_susceptibility_to0.54952494

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.26996566
2Chromosomal breakage induced by crosslinking agents (HP:0003221)3.87325618
3Abnormality of cells of the erythroid lineage (HP:0012130)3.87324424
4Abnormal number of erythroid precursors (HP:0012131)3.86669780
5Chromsome breakage (HP:0040012)3.76587056
6Birth length less than 3rd percentile (HP:0003561)3.64654871
7Oral leukoplakia (HP:0002745)3.48122870
8Hepatocellular necrosis (HP:0001404)3.45978828
9Abnormality of alanine metabolism (HP:0010916)3.44809855
10Hyperalaninemia (HP:0003348)3.44809855
11Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.44809855
12Hepatic necrosis (HP:0002605)3.42020130
13Decreased activity of mitochondrial respiratory chain (HP:0008972)3.39930674
14Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.39930674
15Acute necrotizing encephalopathy (HP:0006965)3.39375036
16Aplastic anemia (HP:0001915)3.38370353
17Mitochondrial inheritance (HP:0001427)3.37166683
18Type I transferrin isoform profile (HP:0003642)3.35995158
193-Methylglutaconic aciduria (HP:0003535)3.32938215
20Increased serum lactate (HP:0002151)3.27825216
21Increased CSF lactate (HP:0002490)3.25149796
22Abnormality of the preputium (HP:0100587)3.24521117
23Breast hypoplasia (HP:0003187)3.18224741
24Abnormal mitochondria in muscle tissue (HP:0008316)3.16897188
25Methylmalonic acidemia (HP:0002912)3.15304359
26Microvesicular hepatic steatosis (HP:0001414)3.14257920
27Acute encephalopathy (HP:0006846)3.01048434
28Macrocytic anemia (HP:0001972)2.98021996
29Meckel diverticulum (HP:0002245)2.91852934
30Abnormality of pyrimidine metabolism (HP:0004353)2.90574880
31Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.88700478
32Reduced antithrombin III activity (HP:0001976)2.83776371
33Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.79978619
34Pallor (HP:0000980)2.77091517
35Abnormality of the ileum (HP:0001549)2.74830685
36Rough bone trabeculation (HP:0100670)2.74219157
37Cerebral hypomyelination (HP:0006808)2.70822898
38Abnormality of aspartate family amino acid metabolism (HP:0010899)2.67392621
39Lactic acidosis (HP:0003128)2.65787843
40Increased hepatocellular lipid droplets (HP:0006565)2.59608742
41Aplasia/Hypoplasia of the uvula (HP:0010293)2.56897086
42Abnormality of chromosome stability (HP:0003220)2.56623157
43Methylmalonic aciduria (HP:0012120)2.53397877
44Abnormality of placental membranes (HP:0011409)2.52342238
45Amniotic constriction ring (HP:0009775)2.52342238
46Pancytopenia (HP:0001876)2.52000988
47Cerebral edema (HP:0002181)2.50641979
48Aplasia/Hypoplasia of the sacrum (HP:0008517)2.49236396
49Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.48154635
50Abnormal protein N-linked glycosylation (HP:0012347)2.48154635
51Abnormal protein glycosylation (HP:0012346)2.48154635
52Abnormal glycosylation (HP:0012345)2.48154635
53Lipid accumulation in hepatocytes (HP:0006561)2.44745264
54Progressive macrocephaly (HP:0004481)2.43984798
55Bone marrow hypocellularity (HP:0005528)2.43195815
56Exercise intolerance (HP:0003546)2.42052974
57Colon cancer (HP:0003003)2.39798196
58Sparse eyelashes (HP:0000653)2.38276176
59Abnormality of serum amino acid levels (HP:0003112)2.37014202
60Leukodystrophy (HP:0002415)2.33021678
61Abnormality of the anterior horn cell (HP:0006802)2.32083673
62Degeneration of anterior horn cells (HP:0002398)2.32083673
63Microretrognathia (HP:0000308)2.31908044
64Premature graying of hair (HP:0002216)2.29321871
65Congenital, generalized hypertrichosis (HP:0004540)2.29151044
66Palpitations (HP:0001962)2.29029406
67Nausea (HP:0002018)2.28064129
68Neoplasm of the adrenal gland (HP:0100631)2.25829863
69Carpal bone hypoplasia (HP:0001498)2.21998406
70Nemaline bodies (HP:0003798)2.21367748
71Increased muscle lipid content (HP:0009058)2.19914686
72Renal Fanconi syndrome (HP:0001994)2.18503155
73Type 2 muscle fiber atrophy (HP:0003554)2.15664454
74Duplicated collecting system (HP:0000081)2.15492539
75Triphalangeal thumb (HP:0001199)2.13025556
76Absent thumb (HP:0009777)2.12509468
77Megaloblastic anemia (HP:0001889)2.12458296
78Horseshoe kidney (HP:0000085)2.12093730
79Exercise-induced muscle cramps (HP:0003710)2.11985088
80Absent radius (HP:0003974)2.11209227
81Abnormal spermatogenesis (HP:0008669)2.11025253
82Lethargy (HP:0001254)2.09028996
83Renal cortical cysts (HP:0000803)2.08766977
84Abnormality of the labia minora (HP:0012880)2.07086098
85Abnormality of glycolysis (HP:0004366)2.06471451
86Increased serum pyruvate (HP:0003542)2.06471451
87Abnormal lung lobation (HP:0002101)2.05993575
88Hyperglycinemia (HP:0002154)2.05665944
89Patellar aplasia (HP:0006443)2.04042673
90Muscle fiber atrophy (HP:0100295)2.03797634
91Increased intramyocellular lipid droplets (HP:0012240)2.02292058
92Small intestinal stenosis (HP:0012848)2.02269938
93Duodenal stenosis (HP:0100867)2.02269938
94CNS demyelination (HP:0007305)2.02073903
95Abnormal trabecular bone morphology (HP:0100671)2.01292839
96Abnormality of renal resorption (HP:0011038)1.98043014
97Respiratory failure (HP:0002878)1.97967977
98Abnormality of the renal collecting system (HP:0004742)1.97423564
99Aplasia involving forearm bones (HP:0009822)1.97011975
100Absent forearm bone (HP:0003953)1.97011975
101Cellular immunodeficiency (HP:0005374)1.93102710
102Aplasia/Hypoplasia of the patella (HP:0006498)1.93055597
103Pancreatic islet-cell hyperplasia (HP:0004510)1.93034827
104Abnormality of dicarboxylic acid metabolism (HP:0010995)1.91755833
105Dicarboxylic aciduria (HP:0003215)1.91755833
106Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.90544883
107Hypoglycemic coma (HP:0001325)1.89056006
108Abnormality of DNA repair (HP:0003254)1.88858556
109Optic disc pallor (HP:0000543)1.88337339
110Muscle fiber inclusion bodies (HP:0100299)1.88270277
111Exertional dyspnea (HP:0002875)1.87959898
112Abnormality of methionine metabolism (HP:0010901)1.87415928
113Opisthotonus (HP:0002179)1.86724749
114Neuroendocrine neoplasm (HP:0100634)1.86407752
115Adrenal hypoplasia (HP:0000835)1.85854093
11611 pairs of ribs (HP:0000878)1.85814893
117Poor head control (HP:0002421)1.85641249
118Generalized aminoaciduria (HP:0002909)1.85471361
119X-linked dominant inheritance (HP:0001423)1.85290817
120Respiratory difficulties (HP:0002880)1.85272677
121Impulsivity (HP:0100710)1.85070121
122Abnormality of sulfur amino acid metabolism (HP:0004339)1.84614752
123Abnormality of the vitamin B12 metabolism (HP:0004341)1.84405502
124Glycosuria (HP:0003076)1.84003142
125Abnormality of urine glucose concentration (HP:0011016)1.84003142
126Progressive muscle weakness (HP:0003323)1.83061081
127Abnormality of vitamin B metabolism (HP:0004340)1.82873618
128Abnormalities of placenta or umbilical cord (HP:0001194)1.82626027
129Myelodysplasia (HP:0002863)1.82188017
130Abnormality of the duodenum (HP:0002246)1.81497961
131Pancreatic cysts (HP:0001737)1.73731363
132Posterior subcapsular cataract (HP:0007787)1.71952662
133Multiple enchondromatosis (HP:0005701)1.71298059
134Neoplasm of the colon (HP:0100273)1.70200279
135Volvulus (HP:0002580)1.69918683

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK165.16527153
2BUB14.68502604
3EIF2AK14.33021727
4VRK23.47193413
5TRIM283.16556979
6NME23.11339538
7WEE12.86715850
8SRPK12.66030034
9EIF2AK32.46228941
10ZAK2.33434118
11VRK12.28696314
12PLK42.19362405
13BCKDK2.19239208
14TLK12.09873661
15NUAK11.98826201
16IRAK31.88277956
17TTK1.83096066
18PIM21.71176361
19MKNK11.67271086
20DYRK31.64378874
21ACVR1B1.63397942
22CDC71.61784133
23EIF2AK21.61528037
24MKNK21.57902694
25PLK11.52194743
26CDK71.51304450
27BRSK21.51195306
28BMPR1B1.50436248
29EPHA21.46530283
30IRAK41.43531215
31AURKB1.31234782
32RPS6KB21.30250702
33ERBB31.29547311
34TAF11.28168703
35BCR1.24183925
36NEK21.21587766
37WNK31.18964353
38AURKA1.18759162
39NME11.17923767
40ATR1.17845568
41CCNB11.17657630
42KDR1.15105482
43PBK1.12338245
44RPS6KA41.07385325
45TAOK21.05302344
46TSSK61.05284973
47AKT31.04285726
48PLK31.03104946
49BRAF1.02904708
50MAP4K20.99485320
51TESK20.96875030
52TXK0.96534149
53PLK20.89989083
54CHEK20.89045845
55PINK10.88603407
56NEK10.86228086
57MAPKAPK30.85846925
58ERBB40.85543209
59CSNK1G10.85413312
60MST1R0.85098417
61FRK0.82002633
62YES10.79666184
63CDK80.78607568
64BRSK10.78426318
65TIE10.78313632
66CSNK1G30.76959436
67RPS6KA50.76819041
68STK30.74697993
69FLT30.74004399
70DAPK10.71847930
71CASK0.71485597
72MYLK0.70740640
73PHKG20.69892281
74PHKG10.69892281
75STK390.69224023
76STK40.68806639
77CSNK2A10.68474931
78PNCK0.67984041
79DYRK20.66320441
80TEC0.66115521
81SIK30.65820683
82BLK0.65502514
83PASK0.63629802
84PAK40.62861824
85MAP3K110.62168148
86CSNK2A20.61361618
87MAP3K80.60215571
88STK100.60204365
89CSNK1G20.60103404
90PDK20.58830799
91CDK40.57774863
92CSNK1A1L0.57705491
93STK38L0.56240041
94OBSCN0.55264206
95IKBKB0.54286013
96CHEK10.52856137
97TGFBR10.51387579
98PAK10.50206088
99MAP3K120.50011366
100CLK10.49837820
101GRK10.49312354
102ADRBK20.48932386
103MUSK0.48687259
104ALK0.48426889
105TNIK0.48292039
106INSRR0.48118010
107PRKCI0.47888211
108TESK10.47175185
109PIM10.47004405
110OXSR10.46889099
111MINK10.44448691
112ATM0.41668991
113MAP2K70.41648119
114NEK90.41527804
115WNK40.40701987
116IRAK10.39910499
117ABL20.39739809
118MAPKAPK50.38635301
119LIMK10.37771515
120MAP2K60.37541761
121BTK0.37362525
122MST40.36920469
123CDK20.36050956
124ILK0.35952673
125PIK3CG0.35507852
126MET0.34144622
127KIT0.33443892
128MAP4K10.33057572
129PAK30.32840579
130AKT20.32357853
131IRAK20.32133138
132TNK20.31008195
133SCYL20.30516316
134BRD40.30316577
135PRPF4B0.29802172
136LYN0.29561169
137RPS6KB10.29357898
138CSNK1E0.29023874
139FGFR10.28810519

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.96350285
2DNA replication_Homo sapiens_hsa030303.94280127
3* Ribosome_Homo sapiens_hsa030103.82175693
4RNA polymerase_Homo sapiens_hsa030203.41355690
5Mismatch repair_Homo sapiens_hsa034303.25328299
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.13287997
7Homologous recombination_Homo sapiens_hsa034402.94226487
8Pyrimidine metabolism_Homo sapiens_hsa002402.74728162
9Base excision repair_Homo sapiens_hsa034102.54644582
10Spliceosome_Homo sapiens_hsa030402.47516227
11Nucleotide excision repair_Homo sapiens_hsa034202.41157417
12One carbon pool by folate_Homo sapiens_hsa006702.35887682
13RNA transport_Homo sapiens_hsa030132.13628465
14Fanconi anemia pathway_Homo sapiens_hsa034602.09636217
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.03468120
16Oxidative phosphorylation_Homo sapiens_hsa001902.01842524
17Folate biosynthesis_Homo sapiens_hsa007901.92930006
18Protein export_Homo sapiens_hsa030601.89362334
19Parkinsons disease_Homo sapiens_hsa050121.85719234
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.61429287
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56991875
22Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.56873065
23Basal transcription factors_Homo sapiens_hsa030221.56118217
24Cell cycle_Homo sapiens_hsa041101.55594837
25Sulfur relay system_Homo sapiens_hsa041221.54969716
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53864200
27Huntingtons disease_Homo sapiens_hsa050161.53686053
28Non-homologous end-joining_Homo sapiens_hsa034501.47311655
29RNA degradation_Homo sapiens_hsa030181.47186711
30Purine metabolism_Homo sapiens_hsa002301.46033040
31Sulfur metabolism_Homo sapiens_hsa009201.35761085
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.33895601
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.28687085
34Vitamin B6 metabolism_Homo sapiens_hsa007501.25101440
35Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.17236025
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.16198155
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.15558688
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.15011740
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.11721424
40Alzheimers disease_Homo sapiens_hsa050101.00423748
41p53 signaling pathway_Homo sapiens_hsa041150.96274087
42Glutathione metabolism_Homo sapiens_hsa004800.96141171
43Pentose phosphate pathway_Homo sapiens_hsa000300.95357637
44Cyanoamino acid metabolism_Homo sapiens_hsa004600.95204780
45Steroid biosynthesis_Homo sapiens_hsa001000.91593275
46Butanoate metabolism_Homo sapiens_hsa006500.85805903
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.85591662
48Systemic lupus erythematosus_Homo sapiens_hsa053220.79348339
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78352378
50Metabolic pathways_Homo sapiens_hsa011000.77864603
51Biosynthesis of amino acids_Homo sapiens_hsa012300.76678931
52Peroxisome_Homo sapiens_hsa041460.74021062
53Vitamin digestion and absorption_Homo sapiens_hsa049770.73473175
54Selenocompound metabolism_Homo sapiens_hsa004500.72485918
55Epstein-Barr virus infection_Homo sapiens_hsa051690.72176250
56Carbon metabolism_Homo sapiens_hsa012000.71866644
57Caffeine metabolism_Homo sapiens_hsa002320.71150571
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70623251
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.70195100
60Oocyte meiosis_Homo sapiens_hsa041140.68578613
61Arachidonic acid metabolism_Homo sapiens_hsa005900.65491810
62Arginine and proline metabolism_Homo sapiens_hsa003300.64590430
63beta-Alanine metabolism_Homo sapiens_hsa004100.61102947
64mRNA surveillance pathway_Homo sapiens_hsa030150.60965059
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59876435
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59437623
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58483686
68Fatty acid metabolism_Homo sapiens_hsa012120.58154911
69Chemical carcinogenesis_Homo sapiens_hsa052040.56674146
70Fructose and mannose metabolism_Homo sapiens_hsa000510.54705058
71Galactose metabolism_Homo sapiens_hsa000520.54701217
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53578230
73Herpes simplex infection_Homo sapiens_hsa051680.53134945
742-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52901479
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51164428
76Fatty acid elongation_Homo sapiens_hsa000620.51146195
77Retinol metabolism_Homo sapiens_hsa008300.51068806
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47686365
79Regulation of autophagy_Homo sapiens_hsa041400.47562608
80Propanoate metabolism_Homo sapiens_hsa006400.45580379
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44170171
82Phenylalanine metabolism_Homo sapiens_hsa003600.43678879
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43487793
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.42801587
85Tyrosine metabolism_Homo sapiens_hsa003500.41751272
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39830906
87Histidine metabolism_Homo sapiens_hsa003400.37586297
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.37326694
89Collecting duct acid secretion_Homo sapiens_hsa049660.36600172
90Other glycan degradation_Homo sapiens_hsa005110.36171618
91Pyruvate metabolism_Homo sapiens_hsa006200.36053931
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.35359344
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34227188
94Intestinal immune network for IgA production_Homo sapiens_hsa046720.33594728
95N-Glycan biosynthesis_Homo sapiens_hsa005100.33511527
96Legionellosis_Homo sapiens_hsa051340.33257086
97Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.32699271
98Linoleic acid metabolism_Homo sapiens_hsa005910.32135149
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.30224112
100Primary immunodeficiency_Homo sapiens_hsa053400.29662828
101Tryptophan metabolism_Homo sapiens_hsa003800.29274987
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28418904
103Phototransduction_Homo sapiens_hsa047440.28005244
104Nitrogen metabolism_Homo sapiens_hsa009100.26992141
105Cardiac muscle contraction_Homo sapiens_hsa042600.26156020
106RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.25840752
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24649704
108Allograft rejection_Homo sapiens_hsa053300.23803779
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.20931030
110Fatty acid degradation_Homo sapiens_hsa000710.20553289
111Antigen processing and presentation_Homo sapiens_hsa046120.19657395
112Starch and sucrose metabolism_Homo sapiens_hsa005000.19576945
113Viral carcinogenesis_Homo sapiens_hsa052030.18277164
114Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.17504526
115alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.16675007
116Vibrio cholerae infection_Homo sapiens_hsa051100.15207547
117TGF-beta signaling pathway_Homo sapiens_hsa043500.15190398
118Circadian rhythm_Homo sapiens_hsa047100.13455492
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.12545350

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