ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	maturation of SSU-rRNA (GO:0030490)	6.92175092
2	ribosomal small subunit biogenesis (GO:0042274)	6.56827771
3	chaperone-mediated protein transport (GO:0072321)	6.22014356
4	regulation of Golgi to plasma membrane protein transport (GO:0042996)	5.52726592
5	DNA deamination (GO:0045006)	5.34952189
6	ribosomal small subunit assembly (GO:0000028)	4.94074276
7	proteasome assembly (GO:0043248)	4.87051411
8	response to redox state (GO:0051775)	4.77934344
9	biotin metabolic process (GO:0006768)	4.71396518
10	protein neddylation (GO:0045116)	4.71063125
11	viral transcription (GO:0019083)	4.61041786
12	respiratory chain complex IV assembly (GO:0008535)	4.54182622
13	translational termination (GO:0006415)	4.45683938
14	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.39203426
15	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.28798400
16	cotranslational protein targeting to membrane (GO:0006613)	4.19691217
17	protein-cofactor linkage (GO:0018065)	4.10996892
18	protein targeting to ER (GO:0045047)	4.10012110
19	translational elongation (GO:0006414)	3.99852558
20	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.92043447
21	protein localization to endoplasmic reticulum (GO:0070972)	3.90945687
22	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.90343110
23	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.90343110
24	NADH dehydrogenase complex assembly (GO:0010257)	3.90343110
25	water-soluble vitamin biosynthetic process (GO:0042364)	3.84691678
26	detection of light stimulus involved in visual perception (GO:0050908)	3.84610223
27	detection of light stimulus involved in sensory perception (GO:0050962)	3.84610223
28	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.81952553
29	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.81952553
30	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.69217760
31	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.65045652
32	cytochrome complex assembly (GO:0017004)	3.62151669
33	misfolded or incompletely synthesized protein catabolic process (GO:0006515)	3.60498036
34	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.58030318
35	positive regulation of T cell apoptotic process (GO:0070234)	3.56883043
36	tongue development (GO:0043586)	3.55685620
37	respiratory electron transport chain (GO:0022904)	3.53633311
38	maturation of 5.8S rRNA (GO:0000460)	3.53589113
39	protein complex biogenesis (GO:0070271)	3.53535398
40	electron transport chain (GO:0022900)	3.48985023
41	auditory receptor cell differentiation (GO:0042491)	3.48329142
42	forebrain neuron differentiation (GO:0021879)	3.42493369
43	positive regulation of oligodendrocyte differentiation (GO:0048714)	3.39466244
44	cellular protein complex disassembly (GO:0043624)	3.37680095
45	viral life cycle (GO:0019058)	3.33581270
46	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.32845369
47	positive regulation of protein sumoylation (GO:0033235)	3.25157258
48	coenzyme catabolic process (GO:0009109)	3.21606270
49	mitochondrial respiratory chain complex assembly (GO:0033108)	3.20803156
50	cardiovascular system development (GO:0072358)	3.17407358
51	positive regulation of cell size (GO:0045793)	3.14367022
52	translation (GO:0006412)	3.11360827
53	metallo-sulfur cluster assembly (GO:0031163)	3.10421401
54	iron-sulfur cluster assembly (GO:0016226)	3.10421401
55	response to misfolded protein (GO:0051788)	3.08024170
56	platelet dense granule organization (GO:0060155)	3.07592428
57	translational initiation (GO:0006413)	3.06769106
58	response to pheromone (GO:0019236)	3.04958320
59	negative regulation of establishment of protein localization to plasma membrane (GO:0090005)	3.02945163
60	head development (GO:0060322)	3.02576933
61	positive regulation of myoblast differentiation (GO:0045663)	3.01808789
62	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.01512789
63	preassembly of GPI anchor in ER membrane (GO:0016254)	2.99487141
64	peptidyl-histidine modification (GO:0018202)	2.96244591
65	7-methylguanosine mRNA capping (GO:0006370)	2.94646990
66	base-excision repair, AP site formation (GO:0006285)	2.94018380
67	ncRNA catabolic process (GO:0034661)	2.93479634
68	cellular component biogenesis (GO:0044085)	2.93118999
69	mitochondrial RNA metabolic process (GO:0000959)	2.92525952
70	7-methylguanosine RNA capping (GO:0009452)	2.88477506
71	RNA capping (GO:0036260)	2.88477506
72	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.84071513
73	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.83220151
74	regulation of cellular respiration (GO:0043457)	2.80812584
75	rRNA modification (GO:0000154)	2.80096968
76	ribonucleoprotein complex biogenesis (GO:0022613)	2.78379129
77	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.77638442
78	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.77364794
79	ATP synthesis coupled proton transport (GO:0015986)	2.77364794
80	protein complex disassembly (GO:0043241)	2.76770649
81	chromatin remodeling at centromere (GO:0031055)	2.76661158
82	positive regulation of lymphocyte apoptotic process (GO:0070230)	2.76129998
83	C-terminal protein lipidation (GO:0006501)	2.73768122
84	GPI anchor metabolic process (GO:0006505)	2.73167807
85	lipopolysaccharide biosynthetic process (GO:0009103)	2.72626336
86	positive regulation of respiratory burst (GO:0060267)	2.69819087
87	mRNA catabolic process (GO:0006402)	2.68719220
88	seminiferous tubule development (GO:0072520)	2.68579505
89	protein targeting to membrane (GO:0006612)	2.68056643
90	DNA double-strand break processing (GO:0000729)	2.67687422
91	spinal cord association neuron differentiation (GO:0021527)	2.67616179
92	macromolecular complex disassembly (GO:0032984)	2.65553053
93	GTP biosynthetic process (GO:0006183)	2.65450458
94	nucleotide-excision repair, DNA gap filling (GO:0006297)	2.65391186
95	coenzyme A metabolic process (GO:0015936)	2.64610035
96	spliceosomal complex assembly (GO:0000245)	2.59278222
97	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.58762596
98	epithelial cilium movement (GO:0003351)	2.58741428
99	cellular response to oxygen radical (GO:0071450)	2.55487659
100	cellular response to superoxide (GO:0071451)	2.55487659

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.22384012
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.28349824
3	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.91507966
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.71361165
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.54455226
6	EZH2_22144423_ChIP-Seq_EOC_Human	3.28896149
7	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.10246831
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.08760024
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.97849944
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.97154504
11	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.88402517
12	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.87615227
13	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.73216516
14	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.69772330
15	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.50881209
16	MYC_18940864_ChIP-ChIP_HL60_Human	2.46063479
17	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.41647565
18	VDR_23849224_ChIP-Seq_CD4+_Human	2.26297354
19	ELK1_19687146_ChIP-ChIP_HELA_Human	2.24906876
20	IRF1_19129219_ChIP-ChIP_H3396_Human	2.24561953
21	GABP_19822575_ChIP-Seq_HepG2_Human	2.19601339
22	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.07289891
23	ZNF274_21170338_ChIP-Seq_K562_Hela	1.97733130
24	FOXP3_21729870_ChIP-Seq_TREG_Human	1.95924308
25	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.86129178
26	EWS_26573619_Chip-Seq_HEK293_Human	1.75216774
27	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.72300819
28	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.69220786
29	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.64291094
30	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.64267257
31	XRN2_22483619_ChIP-Seq_HELA_Human	1.62933318
32	FUS_26573619_Chip-Seq_HEK293_Human	1.61139202
33	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.60153182
34	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.59683337
35	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.55991435
36	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.55199281
37	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.54397524
38	TP53_22573176_ChIP-Seq_HFKS_Human	1.54160038
39	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.52672260
40	DCP1A_22483619_ChIP-Seq_HELA_Human	1.46785559
41	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.43568310
42	TTF2_22483619_ChIP-Seq_HELA_Human	1.42187565
43	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.41816629
44	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.41533868
45	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.38354479
46	CBP_20019798_ChIP-Seq_JUKART_Human	1.37863193
47	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.37863193
48	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.34566434
49	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.30071181
50	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.25803893
51	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.24769511
52	P300_19829295_ChIP-Seq_ESCs_Human	1.22614518
53	RNF2_27304074_Chip-Seq_NSC_Mouse	1.20459772
54	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.19236630
55	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.18025659
56	VDR_22108803_ChIP-Seq_LS180_Human	1.16443152
57	TAF2_19829295_ChIP-Seq_ESCs_Human	1.16324187
58	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.15718226
59	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.13481930
60	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.12031074
61	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.06422247
62	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.06386066
63	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.04841035
64	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.04563180
65	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.03467250
66	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.03348924
67	NCOR_22424771_ChIP-Seq_293T_Human	1.02031211
68	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.01922093
69	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.00420205
70	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.00401638
71	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.99323694
72	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.97536491
73	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.95440378
74	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.94843791
75	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.94075117
76	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.93886525
77	TAF15_26573619_Chip-Seq_HEK293_Human	0.93762994
78	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.93342290
79	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.92699011
80	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.92518441
81	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.92215446
82	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.91971270
83	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.91778301
84	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.90035766
85	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.87737298
86	AR_20517297_ChIP-Seq_VCAP_Human	0.87546391
87	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.87340194
88	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.87222405
89	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.86895638
90	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.84344756
91	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.83796600
92	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.83718948
93	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.83547030
94	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.83378882
95	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.83112521
96	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.82798617
97	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.82184000
98	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.79317410
99	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.78775613
100	BP1_19119308_ChIP-ChIP_Hs578T_Human	0.78609950

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	5.38566184
2	MP0002163_abnormal_gland_morphology	4.58533702
3	MP0006292_abnormal_olfactory_placode	3.92691658
4	MP0009379_abnormal_foot_pigmentation	3.86795899
5	MP0002102_abnormal_ear_morphology	3.16202755
6	MP0000372_irregular_coat_pigmentation	3.03203500
7	MP0005379_endocrine/exocrine_gland_phen	3.00408515
8	MP0002653_abnormal_ependyma_morphology	2.88536451
9	MP0008877_abnormal_DNA_methylation	2.74303829
10	MP0003786_premature_aging	2.67180361
11	MP0003787_abnormal_imprinting	2.58542254
12	MP0005171_absent_coat_pigmentation	2.30856031
13	MP0005253_abnormal_eye_physiology	2.29803790
14	MP0002938_white_spotting	2.28079798
15	MP0002822_catalepsy	2.10985743
16	MP0008995_early_reproductive_senescence	2.09779545
17	MP0002234_abnormal_pharynx_morphology	2.01418669
18	MP0003121_genomic_imprinting	2.00031221
19	MP0001485_abnormal_pinna_reflex	1.93624702
20	MP0008057_abnormal_DNA_replication	1.91150834
21	MP0008058_abnormal_DNA_repair	1.88208911
22	MP0005174_abnormal_tail_pigmentation	1.72689829
23	MP0002095_abnormal_skin_pigmentation	1.68338644
24	MP0003122_maternal_imprinting	1.66808224
25	MP0005646_abnormal_pituitary_gland	1.64311320
26	MP0003186_abnormal_redox_activity	1.63616975
27	MP0006072_abnormal_retinal_apoptosis	1.61354530
28	MP0001764_abnormal_homeostasis	1.59105815
29	MP0001293_anophthalmia	1.55248775
30	MP0003567_abnormal_fetal_cardiomyocyte	1.50918027
31	MP0003880_abnormal_central_pattern	1.50564184
32	MP0005408_hypopigmentation	1.48802276
33	MP0008789_abnormal_olfactory_epithelium	1.47883200
34	MP0005551_abnormal_eye_electrophysiolog	1.47692133
35	MP0000631_abnormal_neuroendocrine_gland	1.43893190
36	MP0006276_abnormal_autonomic_nervous	1.43684101
37	MP0005075_abnormal_melanosome_morpholog	1.43213984
38	MP0008875_abnormal_xenobiotic_pharmacok	1.41511840
39	MP0004885_abnormal_endolymph	1.38999404
40	MP0004858_abnormal_nervous_system	1.36163982
41	MP0003646_muscle_fatigue	1.32950135
42	MP0004133_heterotaxia	1.31861865
43	MP0004145_abnormal_muscle_electrophysio	1.25694212
44	MP0005647_abnormal_sex_gland	1.23278384
45	MP0005645_abnormal_hypothalamus_physiol	1.22014207
46	MP0004142_abnormal_muscle_tone	1.17551635
47	MP0005389_reproductive_system_phenotype	1.17291568
48	MP0000647_abnormal_sebaceous_gland	1.15610974
49	MP0002638_abnormal_pupillary_reflex	1.15016630
50	MP0001919_abnormal_reproductive_system	1.11947146
51	MP0005394_taste/olfaction_phenotype	1.11192179
52	MP0005499_abnormal_olfactory_system	1.11192179
53	MP0004381_abnormal_hair_follicle	1.10430016
54	MP0005391_vision/eye_phenotype	1.09785692
55	MP0002160_abnormal_reproductive_system	1.07938065
56	MP0000026_abnormal_inner_ear	1.04287928
57	MP0000778_abnormal_nervous_system	1.02631163
58	MP0005195_abnormal_posterior_eye	1.01872162
59	MP0000015_abnormal_ear_pigmentation	1.00233114
60	MP0002210_abnormal_sex_determination	0.99701934
61	MP0000049_abnormal_middle_ear	0.94232070
62	MP0002229_neurodegeneration	0.90682579
63	MP0000613_abnormal_salivary_gland	0.89731589
64	MP0001119_abnormal_female_reproductive	0.88905745
65	MP0002132_abnormal_respiratory_system	0.88689326
66	MP0001502_abnormal_circadian_rhythm	0.87477111
67	MP0009697_abnormal_copulation	0.86802035
68	MP0000427_abnormal_hair_cycle	0.86413010
69	MP0005423_abnormal_somatic_nervous	0.86105048
70	MP0000653_abnormal_sex_gland	0.85276648
71	MP0002837_dystrophic_cardiac_calcinosis	0.83481682
72	MP0001486_abnormal_startle_reflex	0.82949256
73	MP0002272_abnormal_nervous_system	0.80211684
74	MP0002752_abnormal_somatic_nervous	0.79701254
75	MP0001905_abnormal_dopamine_level	0.79024914
76	MP0000566_synostosis	0.78667775
77	MP0003938_abnormal_ear_development	0.78511201
78	MP0001145_abnormal_male_reproductive	0.77762527
79	MP0005248_abnormal_Harderian_gland	0.75280334
80	MP0002233_abnormal_nose_morphology	0.74928126
81	MP0002067_abnormal_sensory_capabilities	0.73210754
82	MP0003119_abnormal_digestive_system	0.71243754
83	MP0008872_abnormal_physiological_respon	0.69708403
84	MP0009384_cardiac_valve_regurgitation	0.68255860
85	MP0004742_abnormal_vestibular_system	0.66033359
86	MP0002277_abnormal_respiratory_mucosa	0.64886981
87	MP0010094_abnormal_chromosome_stability	0.64265073
88	MP0004147_increased_porphyrin_level	0.63731457
89	MP0002184_abnormal_innervation	0.63355887
90	MP0008873_increased_physiological_sensi	0.63102546
91	MP0002177_abnormal_outer_ear	0.62473017
92	MP0005332_abnormal_amino_acid	0.62156696
93	MP0009046_muscle_twitch	0.61837608
94	MP0000749_muscle_degeneration	0.61350815
95	MP0005084_abnormal_gallbladder_morpholo	0.61161108
96	MP0001963_abnormal_hearing_physiology	0.60878308
97	MP0003111_abnormal_nucleus_morphology	0.59931752
98	MP0000639_abnormal_adrenal_gland	0.59120018
99	MP0003878_abnormal_ear_physiology	0.58984165
100	MP0005377_hearing/vestibular/ear_phenot	0.58984165

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperventilation (HP:0002883)	4.78194013
2	Reticulocytopenia (HP:0001896)	4.38155222
3	Hepatic necrosis (HP:0002605)	4.32046106
4	Hepatocellular necrosis (HP:0001404)	4.30734638
5	Acute encephalopathy (HP:0006846)	3.99033278
6	Acute necrotizing encephalopathy (HP:0006965)	3.98147220
7	Mitochondrial inheritance (HP:0001427)	3.77058353
8	Papilledema (HP:0001085)	3.68079329
9	Pancreatic fibrosis (HP:0100732)	3.60080618
10	Tachypnea (HP:0002789)	3.59100536
11	Abnormal mitochondria in muscle tissue (HP:0008316)	3.48155648
12	Aplasia/Hypoplasia of the sacrum (HP:0008517)	3.43516381
13	Increased CSF lactate (HP:0002490)	3.23623838
14	Progressive macrocephaly (HP:0004481)	3.20226246
15	Renal cortical cysts (HP:0000803)	3.12813415
16	Abnormality of midbrain morphology (HP:0002418)	3.12637000
17	Molar tooth sign on MRI (HP:0002419)	3.12637000
18	Rib fusion (HP:0000902)	2.94224842
19	Cerebral edema (HP:0002181)	2.89517894
20	Microvesicular hepatic steatosis (HP:0001414)	2.88684451
21	Small hand (HP:0200055)	2.83082345
22	Tubulointerstitial nephritis (HP:0001970)	2.72876331
23	Septo-optic dysplasia (HP:0100842)	2.69054129
24	Sclerocornea (HP:0000647)	2.67962485
25	3-Methylglutaconic aciduria (HP:0003535)	2.65860424
26	Hyperglycinemia (HP:0002154)	2.60740403
27	Esophageal atresia (HP:0002032)	2.59371881
28	Increased serum pyruvate (HP:0003542)	2.50353481
29	Cheilitis (HP:0100825)	2.43124511
30	Pachygyria (HP:0001302)	2.40894536
31	Brittle hair (HP:0002299)	2.39869860
32	Lactic acidosis (HP:0003128)	2.39845748
33	Hypoplasia of the pons (HP:0012110)	2.38520355
34	Hypoplasia of the fovea (HP:0007750)	2.37983794
35	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.37983794
36	Macrocytic anemia (HP:0001972)	2.36998890
37	Entropion (HP:0000621)	2.36357367
38	Abnormality of DNA repair (HP:0003254)	2.34549832
39	Dyskinesia (HP:0100660)	2.34483956
40	Gastrointestinal atresia (HP:0002589)	2.31997483
41	Abnormal hemoglobin (HP:0011902)	2.31713972
42	Pancreatic cysts (HP:0001737)	2.29791756
43	Abnormality of the pons (HP:0007361)	2.29022170
44	Abnormal respiratory epithelium morphology (HP:0012253)	2.27198962
45	Abnormal respiratory motile cilium morphology (HP:0005938)	2.27198962
46	Lethargy (HP:0001254)	2.23951360
47	Proximal tubulopathy (HP:0000114)	2.23868356
48	Chin dimple (HP:0010751)	2.23636201
49	Increased serum lactate (HP:0002151)	2.22904094
50	Generalized aminoaciduria (HP:0002909)	2.22835582
51	Metabolic acidosis (HP:0001942)	2.21821573
52	Abnormality of abdominal situs (HP:0011620)	2.20996408
53	Abdominal situs inversus (HP:0003363)	2.20996408
54	Polyphagia (HP:0002591)	2.20073153
55	Abnormality of lateral ventricle (HP:0030047)	2.19054813
56	Ketosis (HP:0001946)	2.18927727
57	Birth length less than 3rd percentile (HP:0003561)	2.18823818
58	Intestinal atresia (HP:0011100)	2.16836861
59	Pallor (HP:0000980)	2.14538545
60	True hermaphroditism (HP:0010459)	2.13663810
61	Hypoglycemic coma (HP:0001325)	2.13134362
62	Hyperammonemia (HP:0001987)	2.11626878
63	Medial flaring of the eyebrow (HP:0010747)	2.11175540
64	Preaxial hand polydactyly (HP:0001177)	2.08727362
65	Absent thumb (HP:0009777)	2.05066226
66	Abnormality of the labia minora (HP:0012880)	2.04632812
67	Colon cancer (HP:0003003)	2.04305056
68	Long foot (HP:0001833)	2.03876697
69	Abnormality of the renal cortex (HP:0011035)	2.03472709
70	Thyroid-stimulating hormone excess (HP:0002925)	2.02314953
71	Nephronophthisis (HP:0000090)	2.01105771
72	Volvulus (HP:0002580)	2.00773423
73	Abnormality of urine glucose concentration (HP:0011016)	1.99751610
74	Glycosuria (HP:0003076)	1.99751610
75	Abnormality of chromosome stability (HP:0003220)	1.98883897
76	Concave nail (HP:0001598)	1.98483491
77	Vomiting (HP:0002013)	1.97424344
78	Abnormal hair laboratory examination (HP:0003328)	1.94794112
79	Degeneration of anterior horn cells (HP:0002398)	1.94388456
80	Abnormality of the anterior horn cell (HP:0006802)	1.94388456
81	Congenital stationary night blindness (HP:0007642)	1.94048149
82	Increased hepatocellular lipid droplets (HP:0006565)	1.93994809
83	CNS demyelination (HP:0007305)	1.93145226
84	Exercise intolerance (HP:0003546)	1.93142080
85	Tetany (HP:0001281)	1.90957801
86	Facial cleft (HP:0002006)	1.90034388
87	Triphalangeal thumb (HP:0001199)	1.89744727
88	Postaxial foot polydactyly (HP:0001830)	1.86098669
89	Abnormality of glycolysis (HP:0004366)	1.85640619
90	Optic disc pallor (HP:0000543)	1.85220054
91	Median cleft lip (HP:0000161)	1.83890809
92	Absent septum pellucidum (HP:0001331)	1.83551922
93	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.83426375
94	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.83426375
95	Status epilepticus (HP:0002133)	1.83193625
96	Coronal craniosynostosis (HP:0004440)	1.81808617
97	Ectopic kidney (HP:0000086)	1.80681287
98	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.79738238
99	Abnormality of the fovea (HP:0000493)	1.79585965
100	Respiratory failure (HP:0002878)	1.78445501

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK39	4.58960506
2	WNK4	4.03161513
3	BUB1	3.17485503
4	ACVR1B	2.95999197
5	BCR	2.67660303
6	MAP4K2	2.66527225
7	NME1	2.51326160
8	TRIM28	2.44121721
9	BMPR1B	2.37231620
10	NEK1	2.36360578
11	STK16	1.94369381
12	MOS	1.89136490
13	WNK3	1.85775845
14	KDR	1.73123039
15	FRK	1.70184935
16	TYRO3	1.69609040
17	PAK3	1.68976220
18	GRK1	1.62718317
19	BCKDK	1.62216658
20	EPHA4	1.59734508
21	TGFBR1	1.44503797
22	VRK1	1.43232513
23	PINK1	1.39781734
24	TXK	1.32426815
25	PLK2	1.28498079
26	ERBB3	1.27738670
27	TNIK	1.27535189
28	DYRK2	1.24489635
29	MAP2K7	1.23589593
30	WEE1	1.17133559
31	MAPK13	1.14225381
32	NME2	1.10456383
33	PIK3CA	1.07774258
34	LRRK2	1.06898936
35	PAK6	1.05609545
36	MAP3K11	1.01622189
37	SRPK1	0.97331107
38	DMPK	0.97053219
39	FLT3	0.91884619
40	ZAK	0.90225605
41	PLK1	0.86451138
42	ADRBK2	0.85012293
43	MARK3	0.81826971
44	NUAK1	0.80293813
45	ATR	0.80032497
46	UHMK1	0.76571851
47	MINK1	0.76353319
48	PRKCI	0.75374629
49	MAP3K4	0.73843990
50	CHEK2	0.73419382
51	AURKB	0.71499411
52	VRK2	0.69773970
53	PRKCH	0.68108251
54	AURKA	0.67754087
55	CSNK1G3	0.67433407
56	CASK	0.67157155
57	CSNK2A2	0.66607295
58	CAMK2A	0.64467575
59	ARAF	0.64088936
60	CHUK	0.63471453
61	PRKCG	0.63299168
62	EPHA3	0.61660511
63	CSNK2A1	0.61189455
64	OXSR1	0.60708568
65	CDK18	0.59370772
66	PBK	0.59045373
67	IRAK1	0.58896776
68	INSRR	0.58679849
69	PLK3	0.58205900
70	CSNK1G2	0.57793085
71	CAMK1	0.57621709
72	CSNK1A1L	0.56100580
73	PRKACA	0.54091080
74	CDK11A	0.53779958
75	MKNK1	0.51628975
76	CDK14	0.50588447
77	CHEK1	0.49254170
78	CDK15	0.48902703
79	HIPK2	0.46347034
80	NTRK2	0.46157647
81	CDC7	0.45595673
82	SIK3	0.44641778
83	FGFR1	0.43863907
84	DYRK1B	0.43821013
85	PRKCQ	0.43767273
86	OBSCN	0.43407280
87	CSNK1A1	0.42805867
88	CSNK1G1	0.41794088
89	ATM	0.41712317
90	PLK4	0.40081237
91	RPS6KA5	0.38245625
92	PRKCA	0.37825729
93	ADRBK1	0.37103573
94	STK3	0.34305242
95	PRKCE	0.33640194
96	CDK2	0.32912431
97	CAMK2D	0.31334629
98	PRKCB	0.31096163
99	ABL1	0.30087037
100	PRKACB	0.29761165

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.45047335
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.77916914
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.35091306
4	Parkinsons disease_Homo sapiens_hsa05012	3.27777733
5	Protein export_Homo sapiens_hsa03060	3.14019593
6	Propanoate metabolism_Homo sapiens_hsa00640	2.82043478
7	Base excision repair_Homo sapiens_hsa03410	2.72342058
8	Non-homologous end-joining_Homo sapiens_hsa03450	2.67451990
9	Proteasome_Homo sapiens_hsa03050	2.56909960
10	Huntingtons disease_Homo sapiens_hsa05016	2.44621551
11	RNA degradation_Homo sapiens_hsa03018	2.33292731
12	Fanconi anemia pathway_Homo sapiens_hsa03460	2.27292416
13	Homologous recombination_Homo sapiens_hsa03440	2.22374373
14	Mismatch repair_Homo sapiens_hsa03430	2.19151783
15	RNA polymerase_Homo sapiens_hsa03020	2.15996260
16	Alzheimers disease_Homo sapiens_hsa05010	2.14713141
17	Nucleotide excision repair_Homo sapiens_hsa03420	2.14569598
18	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.12461478
19	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.11481678
20	beta-Alanine metabolism_Homo sapiens_hsa00410	2.03360832
21	DNA replication_Homo sapiens_hsa03030	1.92992950
22	Sulfur metabolism_Homo sapiens_hsa00920	1.80175934
23	Cardiac muscle contraction_Homo sapiens_hsa04260	1.71088112
24	Sulfur relay system_Homo sapiens_hsa04122	1.67695722
25	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.63471375
26	Peroxisome_Homo sapiens_hsa04146	1.50014131
27	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.49509543
28	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.48426422
29	Pyrimidine metabolism_Homo sapiens_hsa00240	1.45776641
30	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.42797035
31	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.38415634
32	Basal transcription factors_Homo sapiens_hsa03022	1.35027594
33	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.16730029
34	Spliceosome_Homo sapiens_hsa03040	1.09467924
35	RNA transport_Homo sapiens_hsa03013	1.00093781
36	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.97323640
37	Linoleic acid metabolism_Homo sapiens_hsa00591	0.96440308
38	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.95574567
39	Metabolic pathways_Homo sapiens_hsa01100	0.90392566
40	Phototransduction_Homo sapiens_hsa04744	0.87386638
41	Purine metabolism_Homo sapiens_hsa00230	0.84522355
42	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.82536705
43	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.81013991
44	Chemical carcinogenesis_Homo sapiens_hsa05204	0.80533608
45	Cell cycle_Homo sapiens_hsa04110	0.77639994
46	p53 signaling pathway_Homo sapiens_hsa04115	0.77423496
47	Butanoate metabolism_Homo sapiens_hsa00650	0.77100947
48	Steroid biosynthesis_Homo sapiens_hsa00100	0.75496206
49	mRNA surveillance pathway_Homo sapiens_hsa03015	0.75064542
50	Fat digestion and absorption_Homo sapiens_hsa04975	0.73228047
51	Fatty acid degradation_Homo sapiens_hsa00071	0.73123601
52	Glutathione metabolism_Homo sapiens_hsa00480	0.72612559
53	Nicotine addiction_Homo sapiens_hsa05033	0.71784683
54	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.67013176
55	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.63558825
56	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.63474756
57	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.62736440
58	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.61929224
59	ABC transporters_Homo sapiens_hsa02010	0.60341506
60	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.59816469
61	Olfactory transduction_Homo sapiens_hsa04740	0.58944518
62	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.58090582
63	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.57293953
64	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.56896191
65	Nitrogen metabolism_Homo sapiens_hsa00910	0.56386745
66	Arginine and proline metabolism_Homo sapiens_hsa00330	0.55429644
67	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.52796846
68	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.50581054
69	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.49770806
70	Pyruvate metabolism_Homo sapiens_hsa00620	0.49412347
71	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.47559140
72	One carbon pool by folate_Homo sapiens_hsa00670	0.47037462
73	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.45669084
74	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.45506912
75	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.42863606
76	Hippo signaling pathway_Homo sapiens_hsa04390	0.42303907
77	Primary immunodeficiency_Homo sapiens_hsa05340	0.41539789
78	Morphine addiction_Homo sapiens_hsa05032	0.39355370
79	Folate biosynthesis_Homo sapiens_hsa00790	0.36596577
80	Tryptophan metabolism_Homo sapiens_hsa00380	0.34677318
81	Oocyte meiosis_Homo sapiens_hsa04114	0.33705321
82	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.32269018
83	Circadian rhythm_Homo sapiens_hsa04710	0.31520720
84	Tyrosine metabolism_Homo sapiens_hsa00350	0.31309997
85	Retinol metabolism_Homo sapiens_hsa00830	0.31167299
86	Collecting duct acid secretion_Homo sapiens_hsa04966	0.30893653
87	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.30062079
88	Ether lipid metabolism_Homo sapiens_hsa00565	0.27745166
89	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.26770716
90	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.24927749
91	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.23175312
92	Selenocompound metabolism_Homo sapiens_hsa00450	0.21592011
93	GABAergic synapse_Homo sapiens_hsa04727	0.21088311
94	Dopaminergic synapse_Homo sapiens_hsa04728	0.20321455
95	Glycerolipid metabolism_Homo sapiens_hsa00561	0.19873036
96	Basal cell carcinoma_Homo sapiens_hsa05217	0.19321412
97	Taste transduction_Homo sapiens_hsa04742	0.18048391
98	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.17929740
99	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.15457887
100	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.15429322

MRPS10P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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