MRPS12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S12P family. The encoded protein is a key component of the ribosomal small subunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics. The gene for mitochondrial seryl-tRNA synthetase is located upstream and adjacent to this gene, and both genes are possible candidates for the autosomal dominant deafness gene (DFNA4). Splice variants that differ in the 5' UTR have been found for this gene; all three variants encode the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.55680012
2DNA deamination (GO:0045006)6.43089132
3ATP synthesis coupled proton transport (GO:0015986)6.13686678
4energy coupled proton transport, down electrochemical gradient (GO:0015985)6.13686678
5amyloid precursor protein catabolic process (GO:0042987)5.60961137
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.52410500
7proteasome assembly (GO:0043248)5.41041673
8muscle cell fate commitment (GO:0042693)5.23530045
9respiratory electron transport chain (GO:0022904)5.14220826
10ribosomal small subunit assembly (GO:0000028)5.09281269
11electron transport chain (GO:0022900)5.02917212
12regulation of mitochondrial translation (GO:0070129)4.87707856
13pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.83593918
14protein complex biogenesis (GO:0070271)4.82138197
15muscle organ morphogenesis (GO:0048644)4.68397784
16mitochondrial respiratory chain complex assembly (GO:0033108)4.62976665
17viral transcription (GO:0019083)4.62574418
18establishment of protein localization to mitochondrial membrane (GO:0090151)4.62418275
19mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.61299655
20mitochondrial respiratory chain complex I assembly (GO:0032981)4.61299655
21NADH dehydrogenase complex assembly (GO:0010257)4.61299655
22chaperone-mediated protein transport (GO:0072321)4.56623657
23ribosomal small subunit biogenesis (GO:0042274)4.53305852
24SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.53250277
25cotranslational protein targeting to membrane (GO:0006613)4.51671508
26translational termination (GO:0006415)4.51065572
27peptidyl-arginine omega-N-methylation (GO:0035247)4.47238420
28protein targeting to ER (GO:0045047)4.45541680
29pentose metabolic process (GO:0019321)4.41515565
30protein localization to endoplasmic reticulum (GO:0070972)4.31375631
31negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.26031287
32histone arginine methylation (GO:0034969)4.25258013
33oxidative phosphorylation (GO:0006119)4.24392599
34establishment of protein localization to endoplasmic reticulum (GO:0072599)4.20411368
35transcription elongation from RNA polymerase III promoter (GO:0006385)4.18679045
36termination of RNA polymerase III transcription (GO:0006386)4.18679045
37L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.18306395
38regulation of cellular amino acid metabolic process (GO:0006521)4.14498860
39deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.11213742
40* translation (GO:0006412)4.10665521
41translational elongation (GO:0006414)4.07520132
42outer ear morphogenesis (GO:0042473)4.03258152
43respiratory chain complex IV assembly (GO:0008535)4.01477363
44kinetochore assembly (GO:0051382)3.98424018
45maturation of SSU-rRNA (GO:0030490)3.98381339
46rRNA transcription (GO:0009303)3.94945592
47pyrimidine nucleotide catabolic process (GO:0006244)3.94360954
48negative regulation of ligase activity (GO:0051352)3.93891337
49negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.93891337
50positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.89817207
51protein targeting to mitochondrion (GO:0006626)3.89757539
52establishment of protein localization to mitochondrion (GO:0072655)3.89460851
53pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.87200642
54GTP biosynthetic process (GO:0006183)3.87153077
55guanosine-containing compound biosynthetic process (GO:1901070)3.87056543
56DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.84152918
57ribosomal large subunit biogenesis (GO:0042273)3.83147249
58cullin deneddylation (GO:0010388)3.82921758
59tooth mineralization (GO:0034505)3.82823216
60antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.79713096
617-methylguanosine mRNA capping (GO:0006370)3.77930441
62pseudouridine synthesis (GO:0001522)3.77564493
63regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.77562128
64signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.75976827
65intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.75976827
66GDP-mannose metabolic process (GO:0019673)3.74673781
67negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.74633796
68protein deneddylation (GO:0000338)3.74188949
69signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.73545031
70signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.73545031
71signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.73545031
72metallo-sulfur cluster assembly (GO:0031163)3.72170632
73iron-sulfur cluster assembly (GO:0016226)3.72170632
74protein neddylation (GO:0045116)3.71400054
75translational initiation (GO:0006413)3.71034743
76peptidyl-arginine N-methylation (GO:0035246)3.69471120
77peptidyl-arginine methylation (GO:0018216)3.69471120
78RNA capping (GO:0036260)3.69079062
797-methylguanosine RNA capping (GO:0009452)3.69079062
80viral life cycle (GO:0019058)3.68476975
81anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.65165143
82signal transduction involved in DNA damage checkpoint (GO:0072422)3.64714895
83signal transduction involved in DNA integrity checkpoint (GO:0072401)3.64714895
84cytochrome complex assembly (GO:0017004)3.62813177
85cellular component biogenesis (GO:0044085)3.62424587
86pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.61372400
87signal transduction involved in cell cycle checkpoint (GO:0072395)3.58899606
88cellular protein complex disassembly (GO:0043624)3.58216401
89formation of translation preinitiation complex (GO:0001731)3.57884180
90L-methionine salvage (GO:0071267)3.57623965
91L-methionine biosynthetic process (GO:0071265)3.57623965
92amino acid salvage (GO:0043102)3.57623965
93rRNA modification (GO:0000154)3.56573092
94protein localization to mitochondrion (GO:0070585)3.55484907
95ribonucleoside triphosphate biosynthetic process (GO:0009201)3.53003173
96antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.49502156
97UTP biosynthetic process (GO:0006228)3.49029602
98amyloid precursor protein metabolic process (GO:0042982)3.48743836
99peptidyl-histidine modification (GO:0018202)3.47529248
100ribonucleoprotein complex biogenesis (GO:0022613)3.46858816
101protein maturation by protein folding (GO:0022417)3.45934053
102nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.45319010
103deoxyribonucleotide catabolic process (GO:0009264)3.44807933
104exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.43949229
105CTP metabolic process (GO:0046036)3.43797397
106CTP biosynthetic process (GO:0006241)3.43797397
107purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.42044193
1082-deoxyribonucleotide biosynthetic process (GO:0009265)3.41966156
109deoxyribose phosphate biosynthetic process (GO:0046385)3.41966156
110establishment of integrated proviral latency (GO:0075713)3.38837743
111inner mitochondrial membrane organization (GO:0007007)3.38546731
112purine nucleoside triphosphate biosynthetic process (GO:0009145)3.38522647
113spliceosomal snRNP assembly (GO:0000387)3.36120061
114ubiquinone biosynthetic process (GO:0006744)3.35551090
115quinone biosynthetic process (GO:1901663)3.35551090
116pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.35147727
117nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.34094628
118pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.34039395
119positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.33774827
120deoxyribose phosphate catabolic process (GO:0046386)3.32342826
121UTP metabolic process (GO:0046051)3.31676839
122nucleobase-containing small molecule interconversion (GO:0015949)3.29735420
123base-excision repair, AP site formation (GO:0006285)3.29473891
124ATP biosynthetic process (GO:0006754)3.29155941
125positive regulation of ligase activity (GO:0051351)3.26000075
126kinetochore organization (GO:0051383)3.25679015
127regulation of cellular amine metabolic process (GO:0033238)3.21923615
128rRNA processing (GO:0006364)3.21085332
129telomere maintenance via semi-conservative replication (GO:0032201)3.19665426
130nucleoside triphosphate biosynthetic process (GO:0009142)3.19590090
131tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.16421733
132RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.16421733
133mitochondrial transport (GO:0006839)3.13182373
134embryonic viscerocranium morphogenesis (GO:0048703)3.08569279
135pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.05516916

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.88875965
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.45769190
3JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.39717333
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.16408787
5MYC_18555785_ChIP-Seq_MESCs_Mouse4.14920496
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.08779503
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.01440640
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.89471090
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.66076637
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.64430668
11* CREB1_15753290_ChIP-ChIP_HEK293T_Human3.41004052
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.29450527
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.21131168
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.00824329
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.86871531
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.86381532
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.74700418
18THAP11_20581084_ChIP-Seq_MESCs_Mouse2.68912528
19VDR_23849224_ChIP-Seq_CD4+_Human2.66484748
20PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.57623924
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.55988151
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.55631530
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.55110186
24DCP1A_22483619_ChIP-Seq_HELA_Human2.45112048
25XRN2_22483619_ChIP-Seq_HELA_Human2.41470156
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.40550912
27YY1_21170310_ChIP-Seq_MESCs_Mouse2.37968099
28E2F7_22180533_ChIP-Seq_HELA_Human2.33274705
29GABP_19822575_ChIP-Seq_HepG2_Human2.22466520
30* FOXP3_21729870_ChIP-Seq_TREG_Human2.14621637
31* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.97427091
32TTF2_22483619_ChIP-Seq_HELA_Human1.95871494
33ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.92363939
34CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.86090550
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.85857261
36ELK1_19687146_ChIP-ChIP_HELA_Human1.78890765
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.78599132
38FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.75850085
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.73107904
40TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72982207
41ZNF263_19887448_ChIP-Seq_K562_Human1.72521715
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.70041626
43E2F4_17652178_ChIP-ChIP_JURKAT_Human1.63863607
44FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.62040512
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.60213168
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55846179
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.50966009
48ERG_20887958_ChIP-Seq_HPC-7_Mouse1.50325422
49VDR_21846776_ChIP-Seq_THP-1_Human1.48684731
50NANOG_18555785_ChIP-Seq_MESCs_Mouse1.48405572
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.43002828
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41032252
53CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.40740893
54BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.38752287
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34830178
56* ELK1_22589737_ChIP-Seq_MCF10A_Human1.32491244
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28828221
58CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.28275585
59TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.27686838
60MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.26450555
61CIITA_25753668_ChIP-Seq_RAJI_Human1.25661148
62LXR_22292898_ChIP-Seq_THP-1_Human1.25535102
63* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24772775
64* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.24510187
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22276890
66ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.19979839
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19276629
68CTCF_26484167_Chip-Seq_Bcells_Mouse1.19186308
69SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.18822958
70SRY_22984422_ChIP-ChIP_TESTIS_Rat1.17558116
71ELF1_20517297_ChIP-Seq_JURKAT_Human1.16782867
72FOXM1_23109430_ChIP-Seq_U2OS_Human1.16573624
73MYC_18940864_ChIP-ChIP_HL60_Human1.16507437
74TP63_19390658_ChIP-ChIP_HaCaT_Human1.13985873
75BCL6_27268052_Chip-Seq_Bcells_Human1.13934400
76P68_20966046_ChIP-Seq_HELA_Human1.13683036
77MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.12719277
78ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.11858331
79DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10562016
80IRF1_19129219_ChIP-ChIP_H3396_Human1.09140259
81STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06051140
82CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03825899
83CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.00458161
84HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.00319095
85* CTCF_21964334_Chip-Seq_Bcells_Human1.00098567
86MYC_22102868_ChIP-Seq_BL_Human0.99689159
87KDM5A_27292631_Chip-Seq_BREAST_Human0.99444923
88PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98439228
89SA1_27219007_Chip-Seq_ERYTHROID_Human0.97964895
90* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96992285
91HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96800440
92KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.95265032
93CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94231798
94GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93633210
95* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93334963
96BCOR_27268052_Chip-Seq_Bcells_Human0.92709308
97E2F1_21310950_ChIP-Seq_MCF-7_Human0.92557236
98POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.91854103
99YY1_22570637_ChIP-Seq_MALME-3M_Human0.91564375
100CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.90663783
101EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.89543201
102OCT4_18692474_ChIP-Seq_MEFs_Mouse0.89020094
103SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.86477980
104NOTCH1_21737748_ChIP-Seq_TLL_Human0.85892411
105FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84554076
106TBX5_21415370_ChIP-Seq_HL-1_Mouse0.84522055
107* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.83281380
108SOX17_20123909_ChIP-Seq_XEN_Mouse0.83204613
109SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.82485672
110HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.81156411
111E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.80461104
112FOXP1_21924763_ChIP-Seq_HESCs_Human0.80313483
113DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.79956275
114TFEB_21752829_ChIP-Seq_HELA_Human0.77393442
115SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77090669
116SOX2_18555785_ChIP-Seq_MESCs_Mouse0.76175286
117* TET1_21451524_ChIP-Seq_MESCs_Mouse0.76068565
118CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.74224248
119PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.73333029

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002234_abnormal_pharynx_morphology5.25869194
2MP0010030_abnormal_orbit_morphology5.04318607
3MP0003693_abnormal_embryo_hatching4.10251918
4MP0003806_abnormal_nucleotide_metabolis4.07759115
5MP0006036_abnormal_mitochondrial_physio3.34924283
6MP0004957_abnormal_blastocyst_morpholog3.19313562
7MP0009379_abnormal_foot_pigmentation3.15213000
8MP0002249_abnormal_larynx_morphology3.12881868
9MP0001529_abnormal_vocalization3.12206376
10MP0003186_abnormal_redox_activity3.03785905
11MP0000049_abnormal_middle_ear2.95334219
12MP0006035_abnormal_mitochondrial_morpho2.57901989
13MP0001986_abnormal_taste_sensitivity2.50526097
14MP0008932_abnormal_embryonic_tissue2.28703179
15MP0001905_abnormal_dopamine_level2.25040238
16MP0002822_catalepsy2.16250483
17MP0008058_abnormal_DNA_repair2.14895305
18MP0005451_abnormal_body_composition2.14613202
19MP0001764_abnormal_homeostasis2.13070761
20MP0003136_yellow_coat_color2.10087971
21MP0001661_extended_life_span2.08628228
22MP0003111_abnormal_nucleus_morphology2.01634526
23MP0004147_increased_porphyrin_level1.97376909
24MP0008057_abnormal_DNA_replication1.94278473
25MP0003077_abnormal_cell_cycle1.89570679
26MP0006292_abnormal_olfactory_placode1.89526541
27MP0010094_abnormal_chromosome_stability1.87384772
28MP0003718_maternal_effect1.82025599
29MP0009697_abnormal_copulation1.77721201
30MP0002132_abnormal_respiratory_system1.72772939
31MP0005075_abnormal_melanosome_morpholog1.72090031
32MP0004142_abnormal_muscle_tone1.69474788
33MP0002163_abnormal_gland_morphology1.65885145
34MP0002837_dystrophic_cardiac_calcinosis1.65325063
35MP0002638_abnormal_pupillary_reflex1.60004495
36MP0004133_heterotaxia1.59394949
37MP0006276_abnormal_autonomic_nervous1.57142017
38MP0005501_abnormal_skin_physiology1.52770938
39MP0003195_calcinosis1.51955742
40MP0000681_abnormal_thyroid_gland1.51949901
41MP0005379_endocrine/exocrine_gland_phen1.48122811
42MP0005084_abnormal_gallbladder_morpholo1.47094420
43MP0002796_impaired_skin_barrier1.46416131
44MP0008004_abnormal_stomach_pH1.45951046
45MP0003880_abnormal_central_pattern1.44830961
46MP0004043_abnormal_pH_regulation1.42958636
47MP0005636_abnormal_mineral_homeostasis1.35836909
48MP0001873_stomach_inflammation1.34509989
49MP0005266_abnormal_metabolism1.32792912
50MP0000358_abnormal_cell_content/1.32766732
51MP0000762_abnormal_tongue_morphology1.31205413
52MP0009333_abnormal_splenocyte_physiolog1.26002091
53MP0002177_abnormal_outer_ear1.25772833
54MP0004185_abnormal_adipocyte_glucose1.19731938
55MP0003786_premature_aging1.18726332
56MP0001919_abnormal_reproductive_system1.17722049
57MP0000350_abnormal_cell_proliferation1.16527010
58MP0000372_irregular_coat_pigmentation1.14831302
59MP0002876_abnormal_thyroid_physiology1.14772307
60MP0000750_abnormal_muscle_regeneration1.14590060
61MP0005332_abnormal_amino_acid1.14107718
62MP0000749_muscle_degeneration1.12927022
63MP0001727_abnormal_embryo_implantation1.12211180
64MP0002751_abnormal_autonomic_nervous1.11662189
65MP0001346_abnormal_lacrimal_gland1.10975077
66MP0008007_abnormal_cellular_replicative1.10241639
67MP0008260_abnormal_autophagy1.09353271
68MP0005408_hypopigmentation1.08336258
69MP0008877_abnormal_DNA_methylation1.06558868
70MP0002160_abnormal_reproductive_system1.05536721
71MP0002938_white_spotting1.03834190
72MP0005376_homeostasis/metabolism_phenot1.03367628
73MP0001697_abnormal_embryo_size1.03285815
74MP0001293_anophthalmia1.03042344
75MP0003646_muscle_fatigue1.02920336
76MP0000733_abnormal_muscle_development1.02391844
77MP0005083_abnormal_biliary_tract1.00770607
78MP0006072_abnormal_retinal_apoptosis1.00436263
79MP0000678_abnormal_parathyroid_gland1.00407349
80MP0003123_paternal_imprinting0.99080253
81MP0005670_abnormal_white_adipose0.98556231
82MP0005058_abnormal_lysosome_morphology0.98005297
83MP0003656_abnormal_erythrocyte_physiolo0.95749706
84MP0003315_abnormal_perineum_morphology0.95600559
85MP0000462_abnormal_digestive_system0.93837036
86MP0002736_abnormal_nociception_after0.92946662
87MP0004145_abnormal_muscle_electrophysio0.92824196
88MP0002210_abnormal_sex_determination0.90345251
89MP0004233_abnormal_muscle_weight0.87290672
90MP0000313_abnormal_cell_death0.86099060
91MP0008875_abnormal_xenobiotic_pharmacok0.85759005
92MP0002127_abnormal_cardiovascular_syste0.84169226
93MP0002693_abnormal_pancreas_physiology0.83701967
94MP0005330_cardiomyopathy0.83278082
95MP0001485_abnormal_pinna_reflex0.83274709
96MP0005085_abnormal_gallbladder_physiolo0.82878796
97MP0005380_embryogenesis_phenotype0.82478322
98MP0001672_abnormal_embryogenesis/_devel0.82478322
99MP0009053_abnormal_anal_canal0.82023330
100MP0008872_abnormal_physiological_respon0.81936972
101MP0001188_hyperpigmentation0.81529511
102MP0003567_abnormal_fetal_cardiomyocyte0.80122349
103MP0000490_abnormal_crypts_of0.79615701
104MP0002080_prenatal_lethality0.79126792
105MP0001853_heart_inflammation0.78922677
106MP0009250_abnormal_appendicular_skeleto0.78479668
107MP0010386_abnormal_urinary_bladder0.78180711
108MP0002272_abnormal_nervous_system0.77052931
109MP0005389_reproductive_system_phenotype0.76854500
110MP0001730_embryonic_growth_arrest0.76527605
111MP0001145_abnormal_male_reproductive0.75497608
112MP0002148_abnormal_hypersensitivity_rea0.75447482
113MP0009643_abnormal_urine_homeostasis0.75071195
114MP0009840_abnormal_foam_cell0.73346488
115MP0005584_abnormal_enzyme/coenzyme_acti0.72926848
116MP0005319_abnormal_enzyme/_coenzyme0.72804820
117MP0003724_increased_susceptibility_to0.72304705
118MP0005499_abnormal_olfactory_system0.71129315
119MP0005394_taste/olfaction_phenotype0.71129315
120MP0002396_abnormal_hematopoietic_system0.70315034
121MP0009785_altered_susceptibility_to0.69872513
122MP0001881_abnormal_mammary_gland0.68571302
123MP0003984_embryonic_growth_retardation0.67448615
124MP0001929_abnormal_gametogenesis0.66900459
125MP0000703_abnormal_thymus_morphology0.66240448
126MP0002019_abnormal_tumor_incidence0.66056489
127MP0005645_abnormal_hypothalamus_physiol0.65050008
128MP0001542_abnormal_bone_strength0.64891279
129MP0003866_abnormal_defecation0.64620048
130MP0002932_abnormal_joint_morphology0.63301880
131MP0000653_abnormal_sex_gland0.62990460
132MP0005365_abnormal_bile_salt0.62456130
133MP0005671_abnormal_response_to0.62412226
134MP0001879_abnormal_lymphatic_vessel0.62048304
135MP0002088_abnormal_embryonic_growth/wei0.61989196
136MP0002085_abnormal_embryonic_tissue0.61971325
137MP0002277_abnormal_respiratory_mucosa0.61952834
138MP0002139_abnormal_hepatobiliary_system0.61476232
139MP0002877_abnormal_melanocyte_morpholog0.61383138
140MP0005174_abnormal_tail_pigmentation0.61252030
141MP0000015_abnormal_ear_pigmentation0.61150602
142MP0002332_abnormal_exercise_endurance0.59616660
143MP0001968_abnormal_touch/_nociception0.58622695
144MP0003137_abnormal_impulse_conducting0.57768686
145MP0003638_abnormal_response/metabolism_0.57736157
146MP0002735_abnormal_chemical_nociception0.57217755
147MP0008873_increased_physiological_sensi0.56668307
148MP0005220_abnormal_exocrine_pancreas0.56618991
149MP0001191_abnormal_skin_condition0.56477128
150MP0003937_abnormal_limbs/digits/tail_de0.55014162
151MP0003938_abnormal_ear_development0.50918041
152MP0002697_abnormal_eye_size0.49854098
153MP0003698_abnormal_male_reproductive0.49832535
154MP0008995_early_reproductive_senescence0.49174407
155MP0002254_reproductive_system_inflammat0.48387251

Predicted human phenotypes

RankGene SetZ-score
1Congenital malformation of the right heart (HP:0011723)6.43332321
2Double outlet right ventricle (HP:0001719)6.43332321
3Acute necrotizing encephalopathy (HP:0006965)6.21077958
4Abnormal mitochondria in muscle tissue (HP:0008316)5.74811866
5Mitochondrial inheritance (HP:0001427)5.71146806
6Acute encephalopathy (HP:0006846)5.28894502
7Hepatocellular necrosis (HP:0001404)5.18478921
8Increased CSF lactate (HP:0002490)5.08904086
9Progressive macrocephaly (HP:0004481)4.98093814
10Hepatic necrosis (HP:0002605)4.90302605
11Decreased activity of mitochondrial respiratory chain (HP:0008972)4.67878205
12Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.67878205
13Increased hepatocellular lipid droplets (HP:0006565)4.58410858
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.40455119
15Lipid accumulation in hepatocytes (HP:0006561)4.38921988
16Abnormality of cells of the erythroid lineage (HP:0012130)4.29582722
17Muscle abnormality related to mitochondrial dysfunction (HP:0003800)4.19836891
18Abnormal number of erythroid precursors (HP:0012131)4.14616274
19Hypoplastic left heart (HP:0004383)3.99848774
20Increased serum lactate (HP:0002151)3.93877840
21Truncus arteriosus (HP:0001660)3.93782382
22Increased intramyocellular lipid droplets (HP:0012240)3.90460949
23Renal Fanconi syndrome (HP:0001994)3.87511607
243-Methylglutaconic aciduria (HP:0003535)3.85285725
25Lactic acidosis (HP:0003128)3.84958171
26Cerebral edema (HP:0002181)3.81396216
27Unilateral renal agenesis (HP:0000122)3.60248641
28Exercise intolerance (HP:0003546)3.57583201
29Respiratory failure (HP:0002878)3.53721098
30Increased muscle lipid content (HP:0009058)3.50453807
31Periauricular skin pits (HP:0100277)3.44208438
32Preauricular pit (HP:0004467)3.44208438
33Reticulocytopenia (HP:0001896)3.41440595
34Cerebral hypomyelination (HP:0006808)3.34494144
35Abnormality of glycolysis (HP:0004366)3.32830203
36Increased serum pyruvate (HP:0003542)3.32830203
37Exertional dyspnea (HP:0002875)3.27053981
38Abnormality of the aortic arch (HP:0012303)3.24441690
39Hypoplastic heart (HP:0001961)3.23356583
40Sclerocornea (HP:0000647)3.17642783
41Abnormal ventriculo-arterial connection (HP:0011563)3.15072214
42Transposition of the great arteries (HP:0001669)3.15072214
43Abnormal connection of the cardiac segments (HP:0011545)3.15072214
44Aplastic anemia (HP:0001915)3.14546675
45Leukodystrophy (HP:0002415)3.08060718
46Type I transferrin isoform profile (HP:0003642)2.99217700
47Optic disc pallor (HP:0000543)2.96285600
48Macrocytic anemia (HP:0001972)2.90637620
49Hyperthyroidism (HP:0000836)2.86343816
50Hypoplasia of the uterus (HP:0000013)2.81044578
51Recurrent bacterial skin infections (HP:0005406)2.72835005
52CNS demyelination (HP:0007305)2.71904958
53Redundant skin (HP:0001582)2.69221821
54Aplasia/Hypoplasia of the macula (HP:0008059)2.67738136
55Respiratory difficulties (HP:0002880)2.67278820
56Emotional lability (HP:0000712)2.64111009
57Oral leukoplakia (HP:0002745)2.61630571
58Hypertensive crisis (HP:0100735)2.58575888
59Abnormality of the parathyroid morphology (HP:0011766)2.58350958
60Lethargy (HP:0001254)2.57340831
61Tetany (HP:0001281)2.56725440
62Abnormality of T cell physiology (HP:0011840)2.55385142
63Aplasia/Hypoplasia of the sacrum (HP:0008517)2.50383168
64Aplasia/Hypoplasia affecting the retina (HP:0008061)2.48540248
65Abnormality of renal resorption (HP:0011038)2.48251205
66Colon cancer (HP:0003003)2.47542722
67Microvesicular hepatic steatosis (HP:0001414)2.47530757
68Pallor (HP:0000980)2.43431179
69Hypokinesia (HP:0002375)2.40585807
70Abnormality of urine glucose concentration (HP:0011016)2.38525987
71Glycosuria (HP:0003076)2.38525987
72Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.38408218
73Abnormal protein N-linked glycosylation (HP:0012347)2.38408218
74Abnormal protein glycosylation (HP:0012346)2.38408218
75Abnormal glycosylation (HP:0012345)2.38408218
76Rough bone trabeculation (HP:0100670)2.33325805
77Generalized aminoaciduria (HP:0002909)2.27216611
78Hyperphosphaturia (HP:0003109)2.21692857
79Breast hypoplasia (HP:0003187)2.20876921
80Hypergonadotropic hypogonadism (HP:0000815)2.18675264
81CNS hypomyelination (HP:0003429)2.16077511
82Birth length less than 3rd percentile (HP:0003561)2.15277265
83Abnormality of dicarboxylic acid metabolism (HP:0010995)2.13664073
84Dicarboxylic aciduria (HP:0003215)2.13664073
85Increased neuronal autofluorescent lipopigment (HP:0002074)2.13653037
86Seborrheic dermatitis (HP:0001051)2.13044257
87Pancytopenia (HP:0001876)2.10615222
88Abnormality of aromatic amino acid family metabolism (HP:0004338)2.07241582
89Abnormality of the heme biosynthetic pathway (HP:0010472)2.05028751
90Skin pits (HP:0100276)2.02854624
91Methylmalonic aciduria (HP:0012120)2.00278491
92Poor head control (HP:0002421)2.00195091
93Unsteady gait (HP:0002317)1.98122120
94Microretrognathia (HP:0000308)1.95093158
95Delusions (HP:0000746)1.93010647
96Aplasia/hypoplasia of the uterus (HP:0008684)1.92880599
97Multiple enchondromatosis (HP:0005701)1.91623119
98Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.90683828
99Progressive external ophthalmoplegia (HP:0000590)1.90556547
100Recurrent abscess formation (HP:0002722)1.90500181
101Reduced antithrombin III activity (HP:0001976)1.89020944
102Hypothermia (HP:0002045)1.88378162
103Neuroendocrine neoplasm (HP:0100634)1.87527747
104Selective tooth agenesis (HP:0001592)1.86898860
105Progressive muscle weakness (HP:0003323)1.85966245
106Male infertility (HP:0003251)1.85394237
107Abnormality of the tricuspid valve (HP:0001702)1.84220390
108Brushfield spots (HP:0001088)1.83640381
109Neoplasm of the adrenal cortex (HP:0100641)1.83317203
110Amblyopia (HP:0000646)1.83134405
111Pulmonary artery stenosis (HP:0004415)1.83033612
112Poor suck (HP:0002033)1.82856918
113Muscle fiber atrophy (HP:0100295)1.81835778
114Premature graying of hair (HP:0002216)1.81629489
115Congenital ichthyosiform erythroderma (HP:0007431)1.81442445
116Visual hallucinations (HP:0002367)1.80954486
117Ragged-red muscle fibers (HP:0003200)1.80165846
118Reduced subcutaneous adipose tissue (HP:0003758)1.79111984
119Bulbar palsy (HP:0001283)1.78001409
120Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.77793954
121Abnormality of alanine metabolism (HP:0010916)1.77793954
122Hyperalaninemia (HP:0003348)1.77793954
123Cholelithiasis (HP:0001081)1.77665562
124Hypoparathyroidism (HP:0000829)1.77662142
125Carpal bone hypoplasia (HP:0001498)1.77476338
126Postnatal microcephaly (HP:0005484)1.76701421
127Abnormal trabecular bone morphology (HP:0100671)1.73758344
128Gliosis (HP:0002171)1.70777605
129X-linked dominant inheritance (HP:0001423)1.69885922
130Trismus (HP:0000211)1.68444599
131Vomiting (HP:0002013)1.67495970
132Secondary amenorrhea (HP:0000869)1.67171314
133Type 2 muscle fiber atrophy (HP:0003554)1.65151107
134Pheochromocytoma (HP:0002666)1.64742041
135Blindness (HP:0000618)1.64365257
136Abnormal pupillary function (HP:0007686)1.63457761
137Abnormal urine phosphate concentration (HP:0012599)1.62606788
138Palpitations (HP:0001962)1.59683098
139Duplicated collecting system (HP:0000081)1.56866719
140Abnormality of the anterior horn cell (HP:0006802)1.56071262
141Degeneration of anterior horn cells (HP:0002398)1.56071262
142Opisthotonus (HP:0002179)1.53972689
143Petechiae (HP:0000967)1.52248441

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK27.04406795
2SMG14.95903253
3STK164.76138217
4TAF14.39619317
5NME24.31988269
6BUB14.19826217
7WEE13.04908509
8EIF2AK13.01890882
9BCKDK2.91792848
10NME12.70141217
11ARAF2.68400552
12EIF2AK32.34770086
13VRK12.34176456
14PIM22.24627465
15BRAF2.24433509
16NUAK12.22845184
17MAP3K122.16903954
18PRKD32.11590090
19TESK21.91594310
20SRPK11.82915996
21TSSK61.63309431
22MUSK1.56555806
23TLK11.56493353
24CSNK1A1L1.55317283
25TRIB31.54882080
26PBK1.54451680
27KDR1.52926450
28PLK41.49556773
29MAP3K111.43853515
30CDK191.38359857
31MYLK1.34488560
32CSNK1G11.33581622
33ACVR1B1.30238614
34BRSK21.27294221
35CSNK1G21.26498218
36CCNB11.23216972
37AURKA1.17689000
38CDK81.13279779
39MST41.09157571
40CDC71.09114405
41DYRK31.05302685
42LIMK11.04969993
43IRAK31.03331417
44ABL20.97652047
45PASK0.94814241
46DYRK20.94522828
47BCR0.90057140
48SCYL20.90046438
49PLK10.89699105
50IRAK20.88530499
51TESK10.83417719
52MKNK10.82553794
53MELK0.79231445
54CDK70.78390184
55CDK90.78200189
56MAPK110.78188361
57STK40.78122948
58BRSK10.77237395
59PNCK0.74679771
60TAOK20.74378611
61CAMKK20.72697513
62TNIK0.72537270
63GRK70.72155497
64CSNK2A10.71879724
65PDK20.71799613
66MAPKAPK50.70412049
67CSNK2A20.69250152
68CASK0.67707812
69PRKCI0.66918207
70MKNK20.65891247
71DAPK10.65742371
72MAP2K20.65639289
73AKT30.62637532
74RPS6KB20.61184495
75CAMK2G0.59065173
76AURKB0.58027785
77DAPK30.57839396
78PAK10.57476770
79RPS6KA50.57339899
80SIK30.57060495
81BMPR20.57011426
82IRAK40.56537377
83ZAK0.56059479
84TTK0.53812934
85CSNK1G30.53044163
86PLK30.53014642
87CAMK2B0.51285562
88IKBKB0.51144671
89EPHA20.50871723
90PAK40.49684163
91OXSR10.48487385
92ADRBK20.47875190
93TEC0.47631293
94OBSCN0.47449685
95MAP2K60.47141518
96TYK20.46693831
97BLK0.46543617
98ILK0.46352997
99FLT30.45970110
100AKT20.45187009
101PINK10.44849716
102WNK30.42504406
103CHEK20.42411648
104CAMK2D0.41838177
105ZAP700.41244918
106LRRK20.39993316
107CHEK10.39278179
108IRAK10.38724798
109MAPK150.38415430
110ATR0.38380183
111PIK3CG0.37842400
112NEK10.36871224
113MAP3K80.36321463
114GRK50.36129662
115MAPKAPK30.35796246
116UHMK10.35576692
117STK390.35521232
118EIF2AK20.34198497
119MAP2K70.33319754
120RPS6KA40.32947896
121TXK0.31604412
122WNK40.31318224
123TBK10.30595059
124CDK140.30526099
125GRK60.27922161
126CDK40.24240620
127MAPK40.24127296
128CDK11A0.24072543
129MAPKAPK20.23091538
130CDK150.21747939
131CSNK1A10.19631316
132CDK180.19045796
133MST1R0.18733636
134BMX0.18648104
135GSK3A0.15499929
136ERN10.15418217
137HIPK20.15378586
138MAP3K10.15196316
139TRIM280.14945076
140EPHB20.13938865

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030104.58146923
2Oxidative phosphorylation_Homo sapiens_hsa001904.54668528
3Proteasome_Homo sapiens_hsa030504.51025005
4Parkinsons disease_Homo sapiens_hsa050123.97637787
5RNA polymerase_Homo sapiens_hsa030203.54185378
6Protein export_Homo sapiens_hsa030603.25937239
7Huntingtons disease_Homo sapiens_hsa050162.94354122
8DNA replication_Homo sapiens_hsa030302.84739759
9Alzheimers disease_Homo sapiens_hsa050102.74496114
10Mismatch repair_Homo sapiens_hsa034302.57149159
11Pyrimidine metabolism_Homo sapiens_hsa002402.47445746
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.42808518
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.18472827
14Spliceosome_Homo sapiens_hsa030402.08432723
15Nucleotide excision repair_Homo sapiens_hsa034201.85890655
16Homologous recombination_Homo sapiens_hsa034401.85240207
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.81459546
18Base excision repair_Homo sapiens_hsa034101.78985570
19Folate biosynthesis_Homo sapiens_hsa007901.57335129
20Cardiac muscle contraction_Homo sapiens_hsa042601.44030892
21RNA transport_Homo sapiens_hsa030131.42054992
22Purine metabolism_Homo sapiens_hsa002301.38996345
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.35361452
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.32605584
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.31149807
26Sulfur relay system_Homo sapiens_hsa041221.27074627
27Basal transcription factors_Homo sapiens_hsa030221.23532208
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.18593271
29RNA degradation_Homo sapiens_hsa030181.15554518
30Fatty acid elongation_Homo sapiens_hsa000621.14105346
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.10437393
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.08997498
33Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.07323663
34Glutathione metabolism_Homo sapiens_hsa004801.04149024
35Maturity onset diabetes of the young_Homo sapiens_hsa049501.03163032
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01462558
37Sulfur metabolism_Homo sapiens_hsa009200.99296021
38One carbon pool by folate_Homo sapiens_hsa006700.98069007
39Collecting duct acid secretion_Homo sapiens_hsa049660.97016082
40Metabolic pathways_Homo sapiens_hsa011000.93518700
41SNARE interactions in vesicular transport_Homo sapiens_hsa041300.92160012
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90893153
43Drug metabolism - other enzymes_Homo sapiens_hsa009830.89304432
44Vibrio cholerae infection_Homo sapiens_hsa051100.87087631
45Pyruvate metabolism_Homo sapiens_hsa006200.86008575
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.83721970
47Fanconi anemia pathway_Homo sapiens_hsa034600.82285309
48Carbon metabolism_Homo sapiens_hsa012000.76574499
49Non-homologous end-joining_Homo sapiens_hsa034500.76253960
50Basal cell carcinoma_Homo sapiens_hsa052170.75511198
51Pentose phosphate pathway_Homo sapiens_hsa000300.70531177
52Galactose metabolism_Homo sapiens_hsa000520.70147228
53Peroxisome_Homo sapiens_hsa041460.67333461
54Fructose and mannose metabolism_Homo sapiens_hsa000510.67309999
55Regulation of autophagy_Homo sapiens_hsa041400.66635283
56Phenylalanine metabolism_Homo sapiens_hsa003600.64085371
57Cell cycle_Homo sapiens_hsa041100.62797332
58Biosynthesis of amino acids_Homo sapiens_hsa012300.60708303
59Arginine and proline metabolism_Homo sapiens_hsa003300.58814862
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.57996866
61Arachidonic acid metabolism_Homo sapiens_hsa005900.57853940
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57588257
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.57133745
64Epstein-Barr virus infection_Homo sapiens_hsa051690.55652614
65N-Glycan biosynthesis_Homo sapiens_hsa005100.52960447
66Tyrosine metabolism_Homo sapiens_hsa003500.52265166
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52037314
68Propanoate metabolism_Homo sapiens_hsa006400.47876097
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.47232622
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45978426
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45249676
72Vitamin B6 metabolism_Homo sapiens_hsa007500.43800964
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43601087
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43103977
75Primary immunodeficiency_Homo sapiens_hsa053400.37310319
76Bladder cancer_Homo sapiens_hsa052190.36005834
77Linoleic acid metabolism_Homo sapiens_hsa005910.35057651
78Selenocompound metabolism_Homo sapiens_hsa004500.33555928
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33226567
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33099901
81Histidine metabolism_Homo sapiens_hsa003400.32837413
82Hedgehog signaling pathway_Homo sapiens_hsa043400.31917968
83Other glycan degradation_Homo sapiens_hsa005110.31819132
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28863281
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28062069
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.28027268
87Fatty acid metabolism_Homo sapiens_hsa012120.27768836
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26832342
89Phototransduction_Homo sapiens_hsa047440.26630453
90p53 signaling pathway_Homo sapiens_hsa041150.26501481
91beta-Alanine metabolism_Homo sapiens_hsa004100.26446032
92Systemic lupus erythematosus_Homo sapiens_hsa053220.26364016
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25736011
94Asthma_Homo sapiens_hsa053100.25175670
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.24969402
96Rheumatoid arthritis_Homo sapiens_hsa053230.24347545
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.21982579
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.21218070
99Type I diabetes mellitus_Homo sapiens_hsa049400.20399583
100Chemical carcinogenesis_Homo sapiens_hsa052040.19757902
101Synaptic vesicle cycle_Homo sapiens_hsa047210.19368564
102mRNA surveillance pathway_Homo sapiens_hsa030150.18587474
103Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.18086350
104Butanoate metabolism_Homo sapiens_hsa006500.17377890
105Steroid biosynthesis_Homo sapiens_hsa001000.16405111
106Herpes simplex infection_Homo sapiens_hsa051680.15700609
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.15433563
108Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.14815631
109Primary bile acid biosynthesis_Homo sapiens_hsa001200.14453576
110Notch signaling pathway_Homo sapiens_hsa043300.13962302
111HTLV-I infection_Homo sapiens_hsa051660.12507498
112Alcoholism_Homo sapiens_hsa050340.11670600
113Ether lipid metabolism_Homo sapiens_hsa005650.11587486
114Fatty acid degradation_Homo sapiens_hsa000710.09999038
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.07660303
116Vitamin digestion and absorption_Homo sapiens_hsa049770.04933493
117Apoptosis_Homo sapiens_hsa042100.04330102
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.04320380
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.04249622
120Sphingolipid metabolism_Homo sapiens_hsa006000.03882733

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