MRPS14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S14P family. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.67783439
2ATP synthesis coupled proton transport (GO:0015986)5.40157150
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.40157150
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.09794590
5DNA deamination (GO:0045006)5.03784150
6proteasome assembly (GO:0043248)5.00390859
7ribosomal small subunit assembly (GO:0000028)4.90227476
8ribosomal small subunit biogenesis (GO:0042274)4.65603816
9respiratory electron transport chain (GO:0022904)4.52334273
10electron transport chain (GO:0022900)4.41533269
11protein complex biogenesis (GO:0070271)4.38076351
12transcription elongation from RNA polymerase III promoter (GO:0006385)4.23144187
13termination of RNA polymerase III transcription (GO:0006386)4.23144187
14mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.22946506
15mitochondrial respiratory chain complex I assembly (GO:0032981)4.22946506
16NADH dehydrogenase complex assembly (GO:0010257)4.22946506
17viral transcription (GO:0019083)4.14813638
18regulation of mitochondrial translation (GO:0070129)4.13889524
19maturation of SSU-rRNA (GO:0030490)4.09869208
20translational termination (GO:0006415)4.07043415
21ribosomal large subunit biogenesis (GO:0042273)4.06758314
22protein neddylation (GO:0045116)4.03902160
23mitochondrial respiratory chain complex assembly (GO:0033108)4.01959130
24negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.01473816
25cotranslational protein targeting to membrane (GO:0006613)4.01008358
26chaperone-mediated protein transport (GO:0072321)4.00688705
27SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.99152495
28GTP biosynthetic process (GO:0006183)3.95242977
297-methylguanosine mRNA capping (GO:0006370)3.91836017
30protein targeting to ER (GO:0045047)3.91543027
31respiratory chain complex IV assembly (GO:0008535)3.90106914
327-methylguanosine RNA capping (GO:0009452)3.89117778
33RNA capping (GO:0036260)3.89117778
34rRNA modification (GO:0000154)3.85864478
35establishment of protein localization to mitochondrial membrane (GO:0090151)3.81521820
36regulation of cellular amino acid metabolic process (GO:0006521)3.81237888
37cullin deneddylation (GO:0010388)3.79515505
38protein localization to endoplasmic reticulum (GO:0070972)3.77374497
39positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.72499578
40establishment of protein localization to endoplasmic reticulum (GO:0072599)3.69010388
41* translation (GO:0006412)3.66847035
42DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.66697568
43negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.65311932
44negative regulation of ligase activity (GO:0051352)3.65311932
45regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.65093687
46antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.64824676
47deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.64642012
48protein deneddylation (GO:0000338)3.63998431
49telomere maintenance via semi-conservative replication (GO:0032201)3.63740958
50cytochrome complex assembly (GO:0017004)3.62326909
51signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.62088784
52signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.62088784
53signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.62088784
54signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.60557858
55intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.60557858
56CENP-A containing nucleosome assembly (GO:0034080)3.56277518
57maturation of 5.8S rRNA (GO:0000460)3.55854596
58DNA double-strand break processing (GO:0000729)3.54822148
59anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.54672441
60translational elongation (GO:0006414)3.50699750
61nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.46713191
62signal transduction involved in DNA integrity checkpoint (GO:0072401)3.46540515
63signal transduction involved in DNA damage checkpoint (GO:0072422)3.46540515
64metallo-sulfur cluster assembly (GO:0031163)3.44295772
65iron-sulfur cluster assembly (GO:0016226)3.44295772
66antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.43332401
67exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.43255379
68signal transduction involved in cell cycle checkpoint (GO:0072395)3.43010417
69protein targeting to mitochondrion (GO:0006626)3.42865121
70guanosine-containing compound biosynthetic process (GO:1901070)3.42517894
71water-soluble vitamin biosynthetic process (GO:0042364)3.41709765
72oxidative phosphorylation (GO:0006119)3.41260826
73L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.41175202
74cellular component biogenesis (GO:0044085)3.40347809
75ribonucleoprotein complex biogenesis (GO:0022613)3.39631846
76chromatin remodeling at centromere (GO:0031055)3.38997561
77hydrogen ion transmembrane transport (GO:1902600)3.38696626
78ATP biosynthetic process (GO:0006754)3.36847505
79establishment of protein localization to mitochondrion (GO:0072655)3.35318304
80telomere maintenance via recombination (GO:0000722)3.32411739
81UTP biosynthetic process (GO:0006228)3.31678803
82establishment of integrated proviral latency (GO:0075713)3.30734784
83purine nucleoside triphosphate biosynthetic process (GO:0009145)3.28669352
84transcription-coupled nucleotide-excision repair (GO:0006283)3.28128546
85rRNA methylation (GO:0031167)3.27756291
86cellular protein complex disassembly (GO:0043624)3.26306179
87regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.26200523
88regulation of mitotic spindle checkpoint (GO:1903504)3.26200523
89histone mRNA metabolic process (GO:0008334)3.25501999
90RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.23773774
91tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.23773774
92inner mitochondrial membrane organization (GO:0007007)3.23655000
93viral life cycle (GO:0019058)3.22877062
94purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.22118649
95DNA strand elongation involved in DNA replication (GO:0006271)3.20984419
96translational initiation (GO:0006413)3.20916889
97rRNA processing (GO:0006364)3.20835121
98intracellular protein transmembrane import (GO:0044743)3.18280252
99viral mRNA export from host cell nucleus (GO:0046784)3.16516751
100transcription elongation from RNA polymerase I promoter (GO:0006362)3.15780517
101positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.15700363
102dopamine transport (GO:0015872)3.14960412
103kinetochore assembly (GO:0051382)3.12569041
104termination of RNA polymerase I transcription (GO:0006363)3.11686720
105histone exchange (GO:0043486)3.11561713
106pseudouridine synthesis (GO:0001522)3.10812546
107spliceosomal snRNP assembly (GO:0000387)3.10601964
108DNA strand elongation (GO:0022616)3.09873595
109DNA replication checkpoint (GO:0000076)3.09396145
110positive regulation of ligase activity (GO:0051351)3.08974265
111pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.08386253
112protein localization to mitochondrion (GO:0070585)3.07078743
113rRNA metabolic process (GO:0016072)3.07034576
114peptidyl-histidine modification (GO:0018202)3.05032539
115mitochondrial transport (GO:0006839)3.03963084
116establishment of viral latency (GO:0019043)3.03492557
117regulation of ubiquitin-protein transferase activity (GO:0051438)3.00879270
118DNA ligation (GO:0006266)3.00876393
119DNA catabolic process, exonucleolytic (GO:0000738)3.00132459
120proton transport (GO:0015992)2.99056539
121DNA damage response, detection of DNA damage (GO:0042769)2.96498055
122purine nucleobase biosynthetic process (GO:0009113)2.95614653
123pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.94810923
124hydrogen transport (GO:0006818)2.93848605
125platelet dense granule organization (GO:0060155)2.93241593
126protein-cofactor linkage (GO:0018065)2.90052177
127mannosylation (GO:0097502)2.89537944
128regulation of ligase activity (GO:0051340)2.87918900
129ribonucleoside triphosphate biosynthetic process (GO:0009201)2.86211740
130tRNA processing (GO:0008033)2.81953366
131purine nucleoside monophosphate biosynthetic process (GO:0009127)2.81538371

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.18321094
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.51846720
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.12618538
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.00683897
5E2F7_22180533_ChIP-Seq_HELA_Human3.89708046
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.76925263
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.69345123
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.50982370
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.45156647
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.38913384
11* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.20217218
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.15759474
13* CREB1_15753290_ChIP-ChIP_HEK293T_Human3.11831072
14* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.99826254
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.97247363
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.93640704
17* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.77836009
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.74728161
19* VDR_23849224_ChIP-Seq_CD4+_Human2.70870606
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.61817321
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.46541733
22* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.45554184
23DCP1A_22483619_ChIP-Seq_HELA_Human2.34547247
24* ELK1_19687146_ChIP-ChIP_HELA_Human2.32137713
25FOXP3_21729870_ChIP-Seq_TREG_Human2.24407533
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.22105665
27MYC_19079543_ChIP-ChIP_MESCs_Mouse2.19676632
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.12681255
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.12279601
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.11124803
31THAP11_20581084_ChIP-Seq_MESCs_Mouse2.09900112
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.09145952
33ZNF274_21170338_ChIP-Seq_K562_Hela1.99555276
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.98302479
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.93890861
36* XRN2_22483619_ChIP-Seq_HELA_Human1.93644259
37* YY1_21170310_ChIP-Seq_MESCs_Mouse1.91329905
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.88211951
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.86250305
40* TTF2_22483619_ChIP-Seq_HELA_Human1.85544622
41ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.79646465
42* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.78977085
43GABP_19822575_ChIP-Seq_HepG2_Human1.77203284
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67625565
45FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.66793596
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.61255732
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50537804
48* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50224374
49IGF1R_20145208_ChIP-Seq_DFB_Human1.48785326
50MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.47704611
51BP1_19119308_ChIP-ChIP_Hs578T_Human1.46785408
52* ELK1_22589737_ChIP-Seq_MCF10A_Human1.45039439
53ERG_20887958_ChIP-Seq_HPC-7_Mouse1.44746460
54CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.42586090
55* MYC_18940864_ChIP-ChIP_HL60_Human1.35245533
56* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34033510
57PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33127491
58POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.31926636
59FLI1_27457419_Chip-Seq_LIVER_Mouse1.29649014
60IRF1_19129219_ChIP-ChIP_H3396_Human1.29596512
61* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.26183403
62MYCN_18555785_ChIP-Seq_MESCs_Mouse1.25860841
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.22752467
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.22176463
65NANOG_18555785_ChIP-Seq_MESCs_Mouse1.17182235
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.14537373
67IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.14168297
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12613017
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11974258
70VDR_22108803_ChIP-Seq_LS180_Human1.09806730
71TP53_22573176_ChIP-Seq_HFKS_Human1.09442294
72NANOG_16153702_ChIP-ChIP_HESCs_Human1.09145563
73SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.08318999
74HTT_18923047_ChIP-ChIP_STHdh_Human1.06593172
75SOX2_16153702_ChIP-ChIP_HESCs_Human1.05229801
76BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04937884
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99936362
78P300_19829295_ChIP-Seq_ESCs_Human0.99041697
79SALL1_21062744_ChIP-ChIP_HESCs_Human0.98109738
80CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96803542
81FUS_26573619_Chip-Seq_HEK293_Human0.95120780
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95000253
83ZFX_18555785_ChIP-Seq_MESCs_Mouse0.93438312
84CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92954719
85SPI1_23547873_ChIP-Seq_NB4_Human0.90247598
86E2F1_21310950_ChIP-Seq_MCF-7_Human0.89853042
87KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.89413157
88FOXM1_23109430_ChIP-Seq_U2OS_Human0.88887083
89FOXA1_27270436_Chip-Seq_PROSTATE_Human0.88770107
90FOXA1_25329375_ChIP-Seq_VCAP_Human0.88770107
91AR_20517297_ChIP-Seq_VCAP_Human0.87566152
92AR_21909140_ChIP-Seq_LNCAP_Human0.86987280
93EWS_26573619_Chip-Seq_HEK293_Human0.86642852
94CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.86421709
95RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.85621570
96RBPJ_22232070_ChIP-Seq_NCS_Mouse0.84919484
97KAP1_22055183_ChIP-Seq_ESCs_Mouse0.83684611
98CIITA_25753668_ChIP-Seq_RAJI_Human0.82728765
99NANOG_19829295_ChIP-Seq_ESCs_Human0.82002572
100SOX2_19829295_ChIP-Seq_ESCs_Human0.82002572
101GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81757376
102ZFP57_27257070_Chip-Seq_ESCs_Mouse0.80552487
103CTBP2_25329375_ChIP-Seq_LNCAP_Human0.79499340
104FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.78695668
105GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.78104793
106* SOX17_20123909_ChIP-Seq_XEN_Mouse0.77698241
107PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.77602258
108CTBP1_25329375_ChIP-Seq_LNCAP_Human0.77337933
109TAF15_26573619_Chip-Seq_HEK293_Human0.77334678
110* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76923912
111* NFE2_27457419_Chip-Seq_LIVER_Mouse0.76020394
112SOX2_18555785_ChIP-Seq_MESCs_Mouse0.75605587
113E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.75512810
114NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.74993643
115SUZ12_27294783_Chip-Seq_NPCs_Mouse0.74193697
116POU5F1_16153702_ChIP-ChIP_HESCs_Human0.74086079
117CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.73431294
118* KDM5A_27292631_Chip-Seq_BREAST_Human0.69392231
119* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.69321454
120HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.69122424
121POU3F2_20337985_ChIP-ChIP_501MEL_Human0.66757437
122KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.66224484
123SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.64661911
124STAT4_19710469_ChIP-ChIP_TH1__Mouse0.63071713

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.82600711
2MP0003693_abnormal_embryo_hatching3.72076535
3MP0008058_abnormal_DNA_repair2.96614854
4MP0001529_abnormal_vocalization2.92312071
5MP0004957_abnormal_blastocyst_morpholog2.86892744
6MP0008057_abnormal_DNA_replication2.77517180
7MP0001188_hyperpigmentation2.77179209
8MP0010094_abnormal_chromosome_stability2.65163632
9MP0006292_abnormal_olfactory_placode2.64850195
10MP0001986_abnormal_taste_sensitivity2.55563288
11MP0001905_abnormal_dopamine_level2.51265129
12MP0003136_yellow_coat_color2.41075159
13MP0003186_abnormal_redox_activity2.29500828
14MP0003718_maternal_effect2.22399841
15MP0008932_abnormal_embryonic_tissue2.19223028
16MP0003111_abnormal_nucleus_morphology2.18894709
17MP0003077_abnormal_cell_cycle2.13807496
18MP0003786_premature_aging2.11786958
19MP0003880_abnormal_central_pattern2.03466838
20MP0006036_abnormal_mitochondrial_physio2.02038792
21MP0000372_irregular_coat_pigmentation1.99072902
22MP0009697_abnormal_copulation1.91603888
23MP0002132_abnormal_respiratory_system1.90238937
24MP0002163_abnormal_gland_morphology1.87361351
25MP0008877_abnormal_DNA_methylation1.83251505
26MP0002837_dystrophic_cardiac_calcinosis1.82583920
27MP0008007_abnormal_cellular_replicative1.67602097
28MP0002148_abnormal_hypersensitivity_rea1.60660661
29MP0006276_abnormal_autonomic_nervous1.57157278
30MP0002638_abnormal_pupillary_reflex1.57095848
31MP0004147_increased_porphyrin_level1.55961187
32MP0003724_increased_susceptibility_to1.55053805
33MP0006035_abnormal_mitochondrial_morpho1.54962831
34MP0005379_endocrine/exocrine_gland_phen1.50717653
35MP0005409_darkened_coat_color1.50191251
36MP0005075_abnormal_melanosome_morpholog1.47837520
37MP0005551_abnormal_eye_electrophysiolog1.47529485
38MP0002277_abnormal_respiratory_mucosa1.46780556
39MP0004381_abnormal_hair_follicle1.46093157
40MP0003787_abnormal_imprinting1.45066889
41MP0003195_calcinosis1.43319564
42MP0004142_abnormal_muscle_tone1.37553564
43MP0001346_abnormal_lacrimal_gland1.35881919
44MP0005171_absent_coat_pigmentation1.35735373
45MP0005671_abnormal_response_to1.33384030
46MP0009333_abnormal_splenocyte_physiolog1.31957840
47MP0002876_abnormal_thyroid_physiology1.31392734
48MP0001293_anophthalmia1.31175799
49MP0001835_abnormal_antigen_presentation1.31032621
50MP0003806_abnormal_nucleotide_metabolis1.30785926
51MP0005645_abnormal_hypothalamus_physiol1.28814870
52MP0009785_altered_susceptibility_to1.28095881
53MP0008875_abnormal_xenobiotic_pharmacok1.26055491
54MP0003121_genomic_imprinting1.26029286
55MP0005408_hypopigmentation1.25405969
56MP0000566_synostosis1.25190220
57MP0002102_abnormal_ear_morphology1.22955993
58MP0001764_abnormal_homeostasis1.22598766
59MP0001485_abnormal_pinna_reflex1.21215586
60MP0002160_abnormal_reproductive_system1.19607436
61MP0000015_abnormal_ear_pigmentation1.18700501
62MP0003763_abnormal_thymus_physiology1.16961437
63MP0008260_abnormal_autophagy1.16816604
64MP0005332_abnormal_amino_acid1.16774072
65MP0003315_abnormal_perineum_morphology1.13942347
66MP0002095_abnormal_skin_pigmentation1.09763356
67MP0008872_abnormal_physiological_respon1.09434290
68MP0002736_abnormal_nociception_after1.08576520
69MP0005389_reproductive_system_phenotype1.06132551
70MP0003567_abnormal_fetal_cardiomyocyte1.05333392
71MP0004215_abnormal_myocardial_fiber1.05242196
72MP0000631_abnormal_neuroendocrine_gland1.05123880
73MP0000490_abnormal_crypts_of1.04558527
74MP0002396_abnormal_hematopoietic_system1.04177502
75MP0005084_abnormal_gallbladder_morpholo1.03538541
76MP0001853_heart_inflammation1.00894068
77MP0002938_white_spotting1.00439729
78MP0008789_abnormal_olfactory_epithelium0.99515297
79MP0002090_abnormal_vision0.96263705
80MP0003941_abnormal_skin_development0.95954269
81MP0003123_paternal_imprinting0.95780393
82MP0002210_abnormal_sex_determination0.92993890
83MP0009046_muscle_twitch0.92527323
84MP0005000_abnormal_immune_tolerance0.92237727
85MP0008995_early_reproductive_senescence0.88278051
86MP0001919_abnormal_reproductive_system0.87376145
87MP0005025_abnormal_response_to0.86416752
88MP0000749_muscle_degeneration0.86212514
89MP0001542_abnormal_bone_strength0.85257046
90MP0005174_abnormal_tail_pigmentation0.84533609
91MP0010386_abnormal_urinary_bladder0.83586413
92MP0000681_abnormal_thyroid_gland0.82172685
93MP0005377_hearing/vestibular/ear_phenot0.80463209
94MP0003878_abnormal_ear_physiology0.80463209
95MP0006072_abnormal_retinal_apoptosis0.79541704
96MP0003137_abnormal_impulse_conducting0.79317318
97MP0001984_abnormal_olfaction0.79175837
98MP0002420_abnormal_adaptive_immunity0.78444417
99MP0000358_abnormal_cell_content/0.77540863
100MP0005646_abnormal_pituitary_gland0.77364718
101MP0002751_abnormal_autonomic_nervous0.76730491
102MP0001819_abnormal_immune_cell0.76171592
103MP0002234_abnormal_pharynx_morphology0.75326548
104MP0004133_heterotaxia0.75174092
105MP0004145_abnormal_muscle_electrophysio0.75094553
106MP0005423_abnormal_somatic_nervous0.74793223
107MP0004043_abnormal_pH_regulation0.73987064
108MP0004885_abnormal_endolymph0.73656000
109MP0002272_abnormal_nervous_system0.73222277
110MP0002723_abnormal_immune_serum0.73011912
111MP0001145_abnormal_male_reproductive0.72347546
112MP0002282_abnormal_trachea_morphology0.72279949
113MP0003011_delayed_dark_adaptation0.71051043
114MP0002138_abnormal_hepatobiliary_system0.71005037
115MP0005253_abnormal_eye_physiology0.70962159
116MP0000647_abnormal_sebaceous_gland0.70343975
117MP0001929_abnormal_gametogenesis0.70187687
118MP0000313_abnormal_cell_death0.69753643
119MP0001968_abnormal_touch/_nociception0.69662424
120MP0000689_abnormal_spleen_morphology0.69208800
121MP0001119_abnormal_female_reproductive0.68932328
122MP0002653_abnormal_ependyma_morphology0.68810790
123MP0002419_abnormal_innate_immunity0.68708916
124MP0003937_abnormal_limbs/digits/tail_de0.68355252
125MP0002928_abnormal_bile_duct0.67752437
126MP0000653_abnormal_sex_gland0.67210748
127MP0002452_abnormal_antigen_presenting0.67183898
128MP0009745_abnormal_behavioral_response0.66646943
129MP0005394_taste/olfaction_phenotype0.66402034
130MP0005499_abnormal_olfactory_system0.66402034
131MP0002398_abnormal_bone_marrow0.66352408
132MP0003698_abnormal_male_reproductive0.66328464
133MP0005085_abnormal_gallbladder_physiolo0.65241596
134MP0005410_abnormal_fertilization0.65015192
135MP0001727_abnormal_embryo_implantation0.64950193
136MP0002722_abnormal_immune_system0.64408172
137MP0005391_vision/eye_phenotype0.64096852
138MP0000026_abnormal_inner_ear0.63143764
139MP0003646_muscle_fatigue0.61761691

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.59351649
2Mitochondrial inheritance (HP:0001427)5.22675057
3Abnormal mitochondria in muscle tissue (HP:0008316)5.10494564
4Progressive macrocephaly (HP:0004481)4.60578338
5Increased CSF lactate (HP:0002490)4.60521421
6Hepatocellular necrosis (HP:0001404)4.57574678
7Increased hepatocellular lipid droplets (HP:0006565)4.56659993
8Acute encephalopathy (HP:0006846)4.40305032
9Hepatic necrosis (HP:0002605)4.08970860
103-Methylglutaconic aciduria (HP:0003535)4.08636293
11Lipid accumulation in hepatocytes (HP:0006561)3.99286155
12Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.93101210
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.92053820
14Decreased activity of mitochondrial respiratory chain (HP:0008972)3.92053820
15Renal Fanconi syndrome (HP:0001994)3.90463711
16Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.89974857
17Abnormality of cells of the erythroid lineage (HP:0012130)3.86270715
18Abnormal number of erythroid precursors (HP:0012131)3.72401428
19Reticulocytopenia (HP:0001896)3.54447290
20Increased serum lactate (HP:0002151)3.48783047
21Exertional dyspnea (HP:0002875)3.42510573
22Increased intramyocellular lipid droplets (HP:0012240)3.41806702
23Exercise intolerance (HP:0003546)3.36278522
24Type I transferrin isoform profile (HP:0003642)3.15960812
25Lactic acidosis (HP:0003128)3.13705047
26Respiratory failure (HP:0002878)3.06658829
27Respiratory difficulties (HP:0002880)3.05234137
28Birth length less than 3rd percentile (HP:0003561)3.00890265
29Optic disc pallor (HP:0000543)2.99795209
30Methylmalonic acidemia (HP:0002912)2.95942576
31Increased serum pyruvate (HP:0003542)2.89727462
32Abnormality of glycolysis (HP:0004366)2.89727462
33Cerebral edema (HP:0002181)2.86179321
34Congenital, generalized hypertrichosis (HP:0004540)2.79682325
35Macrocytic anemia (HP:0001972)2.78591078
36Increased muscle lipid content (HP:0009058)2.75995218
37Aplastic anemia (HP:0001915)2.73804243
38Abnormality of renal resorption (HP:0011038)2.64020119
39Microvesicular hepatic steatosis (HP:0001414)2.61748921
40Abnormality of the anterior horn cell (HP:0006802)2.61600022
41Degeneration of anterior horn cells (HP:0002398)2.61600022
42Lethargy (HP:0001254)2.59102461
43Pallor (HP:0000980)2.52602095
44Aplasia/Hypoplasia of the sacrum (HP:0008517)2.50019803
45Molar tooth sign on MRI (HP:0002419)2.48957081
46Abnormality of midbrain morphology (HP:0002418)2.48957081
47Leukodystrophy (HP:0002415)2.47629828
48Abnormality of methionine metabolism (HP:0010901)2.39491531
49Colon cancer (HP:0003003)2.38556698
50Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.37868345
51Chromsome breakage (HP:0040012)2.37499616
52Cerebral hypomyelination (HP:0006808)2.33294353
53Abnormality of alanine metabolism (HP:0010916)2.30093158
54Hyperalaninemia (HP:0003348)2.30093158
55Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.30093158
56Breast hypoplasia (HP:0003187)2.28847916
57Chromosomal breakage induced by crosslinking agents (HP:0003221)2.26845346
58Aplasia/hypoplasia of the uterus (HP:0008684)2.24254118
59Pancreatic fibrosis (HP:0100732)2.23074526
60Abnormality of the preputium (HP:0100587)2.22884873
61True hermaphroditism (HP:0010459)2.20438003
62Type 2 muscle fiber atrophy (HP:0003554)2.20189895
63Nephronophthisis (HP:0000090)2.19385322
64Parakeratosis (HP:0001036)2.18679400
65Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.16394520
66Abnormal protein N-linked glycosylation (HP:0012347)2.16394520
67Abnormal protein glycosylation (HP:0012346)2.16394520
68Abnormal glycosylation (HP:0012345)2.16394520
69Medial flaring of the eyebrow (HP:0010747)2.13635793
70Abnormality of the labia minora (HP:0012880)2.13224047
71Reduced antithrombin III activity (HP:0001976)2.11064032
72Oral leukoplakia (HP:0002745)2.09330953
73Abnormality of aspartate family amino acid metabolism (HP:0010899)2.08987705
74Hyperglycinemia (HP:0002154)2.05620351
75Pancreatic cysts (HP:0001737)2.05112339
76CNS demyelination (HP:0007305)2.05055578
77Renal cortical cysts (HP:0000803)2.04901222
78X-linked dominant inheritance (HP:0001423)2.04572031
79Hypothermia (HP:0002045)2.04513503
80Abnormality of serum amino acid levels (HP:0003112)2.01132555
81Generalized aminoaciduria (HP:0002909)1.99223064
82Hyperglycinuria (HP:0003108)1.98589458
83Pancytopenia (HP:0001876)1.97997929
84Muscle fiber atrophy (HP:0100295)1.97579679
85Abnormality of dicarboxylic acid metabolism (HP:0010995)1.97237675
86Dicarboxylic aciduria (HP:0003215)1.97237675
87Meckel diverticulum (HP:0002245)1.96333036
88Duplicated collecting system (HP:0000081)1.94012432
89Glycosuria (HP:0003076)1.93833747
90Abnormality of urine glucose concentration (HP:0011016)1.93833747
91Abnormality of the ileum (HP:0001549)1.86510219
9211 pairs of ribs (HP:0000878)1.86411952
93Sparse eyelashes (HP:0000653)1.85671055
94Megaloblastic anemia (HP:0001889)1.85443869
95Abnormality of secondary sexual hair (HP:0009888)1.85173103
96Abnormality of the axillary hair (HP:0100134)1.85173103
97Nephrogenic diabetes insipidus (HP:0009806)1.84778704
98Rough bone trabeculation (HP:0100670)1.83958117
99Renal tubular dysfunction (HP:0000124)1.83268318
100Neoplasm of the adrenal gland (HP:0100631)1.82631221
101Abnormality of placental membranes (HP:0011409)1.82435869
102Amniotic constriction ring (HP:0009775)1.82435869
103Abnormality of the renal collecting system (HP:0004742)1.82116591
104Abnormality of the renal cortex (HP:0011035)1.82029775
105Carpal bone hypoplasia (HP:0001498)1.81269532
106Congenital primary aphakia (HP:0007707)1.80915487
107Triphalangeal thumb (HP:0001199)1.80635521
108Abnormality of the renal medulla (HP:0100957)1.80578194
109Hyperphosphaturia (HP:0003109)1.79521599
110Abnormality of vitamin B metabolism (HP:0004340)1.76581731
111Abnormality of the heme biosynthetic pathway (HP:0010472)1.76287299
112Hypoglycemic coma (HP:0001325)1.75321152
113Abnormal lung lobation (HP:0002101)1.74747801
114Abnormality of serine family amino acid metabolism (HP:0010894)1.74744538
115Abnormality of glycine metabolism (HP:0010895)1.74744538
116Sclerocornea (HP:0000647)1.73849005
117Abnormality of chromosome stability (HP:0003220)1.73687971
118Poor head control (HP:0002421)1.72990050
119Emotional lability (HP:0000712)1.72916555
120Congenital stationary night blindness (HP:0007642)1.71436414
121Bifid tongue (HP:0010297)1.70145793
122Abnormal spermatogenesis (HP:0008669)1.69874608
123IgM deficiency (HP:0002850)1.69849651
124Bone marrow hypocellularity (HP:0005528)1.68962244
125Hypoplasia of the uterus (HP:0000013)1.68801034
126Aplasia/Hypoplasia of the uvula (HP:0010293)1.68336908
127Premature graying of hair (HP:0002216)1.68312904
128CNS hypomyelination (HP:0003429)1.67839788
129Abnormal hair whorl (HP:0010721)1.66557087
130Gait imbalance (HP:0002141)1.65218957
131Large for gestational age (HP:0001520)1.65218151
132Intestinal atresia (HP:0011100)1.64970296
133Abnormality of the vitamin B12 metabolism (HP:0004341)1.64781634
134Testicular atrophy (HP:0000029)1.64440624
135Absent thumb (HP:0009777)1.62893514
136Methylmalonic aciduria (HP:0012120)1.62519011
137Congenital ichthyosiform erythroderma (HP:0007431)1.62000575

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.21351908
2VRK24.08696097
3BUB13.40770535
4NME22.83978525
5EIF2AK12.75584349
6VRK12.58916584
7EIF2AK32.47185697
8PBK2.46979975
9MAP3K122.46651218
10WEE12.45452575
11NUAK12.43434615
12SRPK12.24151527
13NME12.23229484
14MST42.07481347
15MAP4K22.03474784
16IRAK32.02868527
17PLK42.02676881
18CASK1.93808850
19TRIM281.93057512
20FRK1.92510970
21TLK11.82327614
22MKNK21.75446851
23ZAK1.69631017
24IRAK41.64633718
25MKNK11.61898226
26WNK31.56996584
27ACVR1B1.56206432
28PIM21.46347872
29TXK1.41144264
30MUSK1.40991685
31ADRBK21.40230479
32BMPR1B1.33750523
33TNIK1.33472643
34TAF11.33092931
35CCNB11.32527915
36BRSK21.31369192
37CDK191.25376061
38MYLK1.20400479
39BMPR21.18421590
40NEK11.16681915
41CDK81.13460923
42ARAF1.12751981
43EIF2AK21.11466392
44TESK21.10854981
45TSSK61.09120516
46MAP2K71.08234288
47CDC71.07696610
48BRAF1.05912748
49CSNK1G11.05766124
50CSNK1G21.02949745
51TEC1.01286007
52PLK31.00440963
53PLK10.96506749
54PDK20.95825391
55BLK0.95309595
56MAPKAPK50.90999938
57KDR0.87821223
58AURKA0.87005892
59CSNK1A1L0.82902123
60GRK70.81684981
61TTK0.80768219
62IRAK10.80755696
63NEK60.78760824
64AURKB0.78604642
65TGFBR10.77215284
66INSRR0.76881941
67PLK20.76598762
68ABL20.73735321
69YES10.73097732
70OXSR10.70821652
71MAP3K40.69447759
72TGFBR20.68706318
73BCR0.68113817
74ERBB30.67444938
75SIK30.67265515
76DYRK20.66354759
77CSNK2A10.66213556
78LIMK10.65774628
79RPS6KA50.65738985
80STK38L0.65627994
81WNK40.63732329
82NLK0.62493098
83DYRK30.62408214
84CHEK20.61930494
85BRSK10.61818627
86CDK70.61713479
87GRK10.60904555
88ATR0.59948522
89PRKCI0.56306958
90FGFR20.56211493
91IRAK20.55203952
92PINK10.54819224
93LYN0.54391346
94PAK30.54216640
95STK240.53786184
96STK30.53775144
97PRKCG0.53619799
98CSNK2A20.52735263
99DAPK10.51979268
100OBSCN0.48191028
101CDK30.47610385
102ATM0.47233853
103STK390.46058517
104CAMK2B0.44089864
105RIPK40.43886415
106PRKCE0.43526314
107CDK90.41952281
108GRK50.41875066
109FER0.41427402
110PNCK0.40876724
111MAP3K140.40256325
112CLK10.40100878
113CSNK1A10.39069856
114NEK20.35877400
115KIT0.35059870
116CAMK2D0.34547953
117BCKDK0.34005243
118AKT30.33909028
119RPS6KB20.33800720
120MAPK130.33580162
121SYK0.32516459
122IKBKB0.32155605
123TNK20.31027297
124CSNK1G30.30949412
125CAMK2G0.30482454
126RPS6KA40.30381939
127STK40.30143684
128TIE10.29134123
129ADRBK10.29008041
130TESK10.28224873
131MINK10.25851784
132CSNK1E0.25447604
133CHEK10.24811521

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.56782284
2* Ribosome_Homo sapiens_hsa030104.50534468
3Oxidative phosphorylation_Homo sapiens_hsa001904.31738515
4Parkinsons disease_Homo sapiens_hsa050123.72562802
5RNA polymerase_Homo sapiens_hsa030203.65930115
6DNA replication_Homo sapiens_hsa030303.14973416
7Protein export_Homo sapiens_hsa030603.08636878
8Huntingtons disease_Homo sapiens_hsa050162.83443123
9Mismatch repair_Homo sapiens_hsa034302.75411661
10Alzheimers disease_Homo sapiens_hsa050102.61108374
11Homologous recombination_Homo sapiens_hsa034402.57106941
12Pyrimidine metabolism_Homo sapiens_hsa002402.43162083
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.41697477
14Nucleotide excision repair_Homo sapiens_hsa034202.20820108
15Spliceosome_Homo sapiens_hsa030402.17108600
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.16899783
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.96315288
18Basal transcription factors_Homo sapiens_hsa030221.88473958
19Base excision repair_Homo sapiens_hsa034101.79305942
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.77682647
21Fanconi anemia pathway_Homo sapiens_hsa034601.72867647
22Propanoate metabolism_Homo sapiens_hsa006401.71751292
23Non-homologous end-joining_Homo sapiens_hsa034501.70703272
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.50477911
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.48914185
26RNA transport_Homo sapiens_hsa030131.48457705
27RNA degradation_Homo sapiens_hsa030181.47622007
28Purine metabolism_Homo sapiens_hsa002301.45274942
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.32710465
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.17199602
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.16050111
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.15400291
33Cardiac muscle contraction_Homo sapiens_hsa042601.14159314
34Cell cycle_Homo sapiens_hsa041101.13014001
35Butanoate metabolism_Homo sapiens_hsa006501.08702714
36Collecting duct acid secretion_Homo sapiens_hsa049661.04168008
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.01492329
38Caffeine metabolism_Homo sapiens_hsa002320.93212651
39Fatty acid elongation_Homo sapiens_hsa000620.92480582
40Selenocompound metabolism_Homo sapiens_hsa004500.91461630
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.91038365
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90994111
43Maturity onset diabetes of the young_Homo sapiens_hsa049500.90103683
44Arachidonic acid metabolism_Homo sapiens_hsa005900.88602737
45Nitrogen metabolism_Homo sapiens_hsa009100.86021378
46Phototransduction_Homo sapiens_hsa047440.85237448
47Glutathione metabolism_Homo sapiens_hsa004800.80448189
48Graft-versus-host disease_Homo sapiens_hsa053320.78156885
49Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77880369
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.77290792
51Folate biosynthesis_Homo sapiens_hsa007900.75749733
52Metabolic pathways_Homo sapiens_hsa011000.75662711
53One carbon pool by folate_Homo sapiens_hsa006700.75473682
54Chemical carcinogenesis_Homo sapiens_hsa052040.73538512
55Epstein-Barr virus infection_Homo sapiens_hsa051690.72202307
56Vibrio cholerae infection_Homo sapiens_hsa051100.70227932
57Allograft rejection_Homo sapiens_hsa053300.69880561
58Rheumatoid arthritis_Homo sapiens_hsa053230.69082631
59Tryptophan metabolism_Homo sapiens_hsa003800.68094344
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63310330
61p53 signaling pathway_Homo sapiens_hsa041150.62990597
62Primary immunodeficiency_Homo sapiens_hsa053400.61810843
63Fatty acid degradation_Homo sapiens_hsa000710.61676617
64Asthma_Homo sapiens_hsa053100.60414175
65beta-Alanine metabolism_Homo sapiens_hsa004100.60223070
66Fatty acid metabolism_Homo sapiens_hsa012120.58616881
67Autoimmune thyroid disease_Homo sapiens_hsa053200.57363702
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56475037
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.55557440
70Retinol metabolism_Homo sapiens_hsa008300.54643176
71Sulfur metabolism_Homo sapiens_hsa009200.54275550
72Sphingolipid metabolism_Homo sapiens_hsa006000.51031380
73Regulation of autophagy_Homo sapiens_hsa041400.50648185
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50603518
75Linoleic acid metabolism_Homo sapiens_hsa005910.50570895
76Ether lipid metabolism_Homo sapiens_hsa005650.49022566
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48887887
78Carbon metabolism_Homo sapiens_hsa012000.47913166
79Systemic lupus erythematosus_Homo sapiens_hsa053220.47710023
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47310759
81Pentose phosphate pathway_Homo sapiens_hsa000300.46091907
82Intestinal immune network for IgA production_Homo sapiens_hsa046720.45261874
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.43139547
84Other glycan degradation_Homo sapiens_hsa005110.41354596
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41257896
86Vitamin B6 metabolism_Homo sapiens_hsa007500.40264024
87Vitamin digestion and absorption_Homo sapiens_hsa049770.39007439
88mRNA surveillance pathway_Homo sapiens_hsa030150.38163379
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37768255
90Type I diabetes mellitus_Homo sapiens_hsa049400.37762775
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.37679003
92Antigen processing and presentation_Homo sapiens_hsa046120.37421305
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37134622
94Hematopoietic cell lineage_Homo sapiens_hsa046400.36530952
952-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.36179370
96Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35368029
97Phagosome_Homo sapiens_hsa041450.33964925
98Herpes simplex infection_Homo sapiens_hsa051680.32382658
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.32311957
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32074871
101Steroid biosynthesis_Homo sapiens_hsa001000.30342104
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30309700
103Biosynthesis of amino acids_Homo sapiens_hsa012300.29336929
104Sulfur relay system_Homo sapiens_hsa041220.28330319
105Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.26507700
106Tyrosine metabolism_Homo sapiens_hsa003500.26495500
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25640523
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.25187363
109N-Glycan biosynthesis_Homo sapiens_hsa005100.24670343
110Legionellosis_Homo sapiens_hsa051340.23323546
111Nicotine addiction_Homo sapiens_hsa050330.22118890
112Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.21647613
113Serotonergic synapse_Homo sapiens_hsa047260.21106836
114Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.20551025
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19508054
116Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.19109193
117Arginine and proline metabolism_Homo sapiens_hsa003300.18945500
118Fat digestion and absorption_Homo sapiens_hsa049750.18598069
119Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.18325695
120Olfactory transduction_Homo sapiens_hsa047400.17512976
121Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.16074750
122Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.15980125
123Alcoholism_Homo sapiens_hsa050340.15830820
124Pyruvate metabolism_Homo sapiens_hsa006200.15320471
125Measles_Homo sapiens_hsa051620.15135932
126NOD-like receptor signaling pathway_Homo sapiens_hsa046210.14980392
127Oocyte meiosis_Homo sapiens_hsa041140.14787554
128Phenylalanine metabolism_Homo sapiens_hsa003600.14581231
129Galactose metabolism_Homo sapiens_hsa000520.12854061
130Peroxisome_Homo sapiens_hsa041460.10887703
131NF-kappa B signaling pathway_Homo sapiens_hsa040640.10295884

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