MRPS16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S16P family. The encoded protein is one of the most highly conserved ribosomal proteins between mammalian and yeast mitochondria. Three pseudogenes (located at 8q21.3, 20q13.32, 22q12-q13.1) for this gene have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.14948248
2viral transcription (GO:0019083)6.17624355
3translational termination (GO:0006415)5.99207992
4DNA deamination (GO:0045006)5.97263888
5ribosomal small subunit biogenesis (GO:0042274)5.82691373
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.47525075
7cotranslational protein targeting to membrane (GO:0006613)5.36861579
8translational elongation (GO:0006414)5.35719743
9protein targeting to ER (GO:0045047)5.33940459
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.10419810
11protein localization to endoplasmic reticulum (GO:0070972)5.09922182
12maturation of SSU-rRNA (GO:0030490)5.06889282
13establishment of protein localization to endoplasmic reticulum (GO:0072599)5.05346135
14proteasome assembly (GO:0043248)4.94741666
15energy coupled proton transport, down electrochemical gradient (GO:0015985)4.87475327
16ATP synthesis coupled proton transport (GO:0015986)4.87475327
17ribosomal large subunit biogenesis (GO:0042273)4.84394541
18viral life cycle (GO:0019058)4.74747490
19translational initiation (GO:0006413)4.63144637
20cellular protein complex disassembly (GO:0043624)4.61947633
21nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.51368076
22mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.44813689
23* translation (GO:0006412)4.41791033
24oxidative phosphorylation (GO:0006119)4.26661305
25respiratory electron transport chain (GO:0022904)4.22147086
26regulation of mitochondrial translation (GO:0070129)4.20617588
27electron transport chain (GO:0022900)4.10719429
28ribonucleoprotein complex biogenesis (GO:0022613)4.08925976
29deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.92370845
30protein complex disassembly (GO:0043241)3.90455011
31transcription elongation from RNA polymerase III promoter (GO:0006385)3.82467788
32termination of RNA polymerase III transcription (GO:0006386)3.82467788
33telomere maintenance via semi-conservative replication (GO:0032201)3.80099087
34macromolecular complex disassembly (GO:0032984)3.74369640
35negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.73829036
36formation of translation preinitiation complex (GO:0001731)3.70719645
37cellular component biogenesis (GO:0044085)3.69584976
38chaperone-mediated protein transport (GO:0072321)3.64544654
39protein complex biogenesis (GO:0070271)3.57553821
40DNA strand elongation involved in DNA replication (GO:0006271)3.55058897
41pseudouridine synthesis (GO:0001522)3.53323344
42antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.51823590
43mitochondrial respiratory chain complex I assembly (GO:0032981)3.51642567
44NADH dehydrogenase complex assembly (GO:0010257)3.51642567
45mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.51642567
46rRNA modification (GO:0000154)3.48524002
47positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.45499717
48DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.45462253
49regulation of cellular amino acid metabolic process (GO:0006521)3.45137414
50rRNA processing (GO:0006364)3.45103223
51establishment of viral latency (GO:0019043)3.44454720
52DNA strand elongation (GO:0022616)3.43289384
53protein targeting to membrane (GO:0006612)3.42849601
54nuclear-transcribed mRNA catabolic process (GO:0000956)3.42604968
55mitochondrial respiratory chain complex assembly (GO:0033108)3.42142132
56negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.39564348
57negative regulation of ligase activity (GO:0051352)3.39564348
58signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.38377073
59intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.38377073
60regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.36966714
61exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.36696896
62signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.35914049
63signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.35914049
64signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.35914049
65respiratory chain complex IV assembly (GO:0008535)3.35130568
66DNA replication checkpoint (GO:0000076)3.34723100
67DNA unwinding involved in DNA replication (GO:0006268)3.33937673
68antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.33006810
69establishment of protein localization to mitochondrial membrane (GO:0090151)3.30834493
70rRNA metabolic process (GO:0016072)3.30154552
71metallo-sulfur cluster assembly (GO:0031163)3.29333041
72iron-sulfur cluster assembly (GO:0016226)3.29333041
73signal transduction involved in DNA damage checkpoint (GO:0072422)3.26579418
74signal transduction involved in DNA integrity checkpoint (GO:0072401)3.26579418
75telomere maintenance via recombination (GO:0000722)3.26370291
76nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.26136002
77anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.25362153
78GTP biosynthetic process (GO:0006183)3.25124045
79mRNA catabolic process (GO:0006402)3.24926319
80purine nucleobase biosynthetic process (GO:0009113)3.24625853
81L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.23354213
82signal transduction involved in cell cycle checkpoint (GO:0072395)3.21756849
83protein targeting to mitochondrion (GO:0006626)3.21317042
84CENP-A containing nucleosome assembly (GO:0034080)3.19475060
85ribosome biogenesis (GO:0042254)3.18421248
86chromatin remodeling at centromere (GO:0031055)3.18278336
87regulation of translational fidelity (GO:0006450)3.15443383
88establishment of protein localization to mitochondrion (GO:0072655)3.14204643
89establishment of integrated proviral latency (GO:0075713)3.13803100
90spliceosomal snRNP assembly (GO:0000387)3.13624247
91maturation of 5.8S rRNA (GO:0000460)3.11196867
92cytochrome complex assembly (GO:0017004)3.09274753
93nucleobase-containing small molecule interconversion (GO:0015949)3.09245311
94inner mitochondrial membrane organization (GO:0007007)3.06730946
95peptidyl-histidine modification (GO:0018202)3.06457413
96RNA catabolic process (GO:0006401)3.05280391
97transcription-coupled nucleotide-excision repair (GO:0006283)3.05225859
98mitotic recombination (GO:0006312)3.04864226
997-methylguanosine mRNA capping (GO:0006370)3.04743143
100mitotic metaphase plate congression (GO:0007080)3.03959373
101L-serine metabolic process (GO:0006563)3.00641486
1027-methylguanosine RNA capping (GO:0009452)2.99930155
103RNA capping (GO:0036260)2.99930155
104guanosine-containing compound biosynthetic process (GO:1901070)2.99191609
105mitotic sister chromatid segregation (GO:0000070)2.97853736
106UTP biosynthetic process (GO:0006228)2.97095991
107ribosome assembly (GO:0042255)2.96995728
108kinetochore organization (GO:0051383)2.95905106
109pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.95247235
110positive regulation of ligase activity (GO:0051351)2.95199747
111pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.93958966
112nucleobase biosynthetic process (GO:0046112)2.93191921
113nucleotide-excision repair, DNA gap filling (GO:0006297)2.92774597
114positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.92699402
115protein localization to mitochondrion (GO:0070585)2.92664440
116telomere maintenance via telomere lengthening (GO:0010833)2.90656001
117tRNA aminoacylation for protein translation (GO:0006418)2.89996727
118double-strand break repair via nonhomologous end joining (GO:0006303)2.89912386
119non-recombinational repair (GO:0000726)2.89912386
120tRNA aminoacylation (GO:0043039)2.89251992
121amino acid activation (GO:0043038)2.89251992
122folic acid-containing compound biosynthetic process (GO:0009396)2.89118377
123cullin deneddylation (GO:0010388)2.88627201
124kinetochore assembly (GO:0051382)2.88444282
125protein deneddylation (GO:0000338)2.86606311

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.60948289
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.36397909
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.18752377
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.10848881
5* GABP_17652178_ChIP-ChIP_JURKAT_Human3.83782151
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.74450004
7* EST1_17652178_ChIP-ChIP_JURKAT_Human3.72596038
8* ETS1_20019798_ChIP-Seq_JURKAT_Human3.41784111
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.12480444
10MYC_18358816_ChIP-ChIP_MESCs_Mouse3.10617640
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.10146493
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.98287677
13* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.90334630
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.84285583
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.74117020
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.74105797
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.64294347
18VDR_23849224_ChIP-Seq_CD4+_Human2.62276406
19* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.61614646
20DCP1A_22483619_ChIP-Seq_HELA_Human2.52518456
21* XRN2_22483619_ChIP-Seq_HELA_Human2.36096196
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.35494896
23E2F1_18555785_ChIP-Seq_MESCs_Mouse2.35272909
24SRF_21415370_ChIP-Seq_HL-1_Mouse2.32433136
25FOXP3_21729870_ChIP-Seq_TREG_Human2.20153254
26* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.17885368
27E2F4_17652178_ChIP-ChIP_JURKAT_Human2.17803944
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.15721557
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.12872107
30NELFA_20434984_ChIP-Seq_ESCs_Mouse2.12086183
31YY1_21170310_ChIP-Seq_MESCs_Mouse2.05781480
32THAP11_20581084_ChIP-Seq_MESCs_Mouse2.04463031
33FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.00747615
34TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.98988032
35GABP_19822575_ChIP-Seq_HepG2_Human1.97612602
36ELK1_19687146_ChIP-ChIP_HELA_Human1.87676322
37TTF2_22483619_ChIP-Seq_HELA_Human1.87360223
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.85554610
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.84917916
40* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.82323842
41CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.72308268
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.71434685
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68027135
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.63811419
45ERG_20887958_ChIP-Seq_HPC-7_Mouse1.61841830
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.56508928
47SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.46534427
48* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.45952813
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.44887526
50DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.42407321
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37670305
52ELK1_22589737_ChIP-Seq_MCF10A_Human1.35807729
53PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.35285596
54DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.34726383
55CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.34594141
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.34053739
57YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33928293
58IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.33395815
59* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.33066157
60BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.30526790
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.26433879
62CIITA_25753668_ChIP-Seq_RAJI_Human1.25759494
63MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.24414927
64STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23616396
65ZNF263_19887448_ChIP-Seq_K562_Human1.18301145
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.17930639
67FOXM1_23109430_ChIP-Seq_U2OS_Human1.17544996
68SPI1_23547873_ChIP-Seq_NB4_Human1.17126521
69TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.17001071
70IRF8_22096565_ChIP-ChIP_GC-B_Human1.15008744
71ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.14640623
72KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.12224937
73* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.10828945
74CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09692967
75ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08777759
76* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.08205034
77MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07926578
78E2F1_21310950_ChIP-Seq_MCF-7_Human1.05754687
79MYC_18940864_ChIP-ChIP_HL60_Human1.04470470
80GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04371340
81KDM5A_27292631_Chip-Seq_BREAST_Human1.03137904
82* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.02510784
83CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01302892
84HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00560776
85FOXP1_21924763_ChIP-Seq_HESCs_Human0.97644366
86RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.97229487
87CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97161308
88PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96803124
89SOX17_20123909_ChIP-Seq_XEN_Mouse0.95591319
90STAT4_19710469_ChIP-ChIP_TH1__Mouse0.95467543
91AR_21909140_ChIP-Seq_LNCAP_Human0.93653096
92TBX5_21415370_ChIP-Seq_HL-1_Mouse0.93415323
93POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.92999930
94TFEB_21752829_ChIP-Seq_HELA_Human0.92577215
95ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91172528
96BP1_19119308_ChIP-ChIP_Hs578T_Human0.90736134
97* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.89135564
98KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88569758
99IRF8_21731497_ChIP-ChIP_J774_Mouse0.88155279
100CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87710033
101HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.87302919
102E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.86414859
103ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.86338309
104* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84234653
105PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.83937917
106SRY_22984422_ChIP-ChIP_TESTIS_Rat0.82673275
107KLF4_18555785_ChIP-Seq_MESCs_Mouse0.82326982
108GATA1_22025678_ChIP-Seq_K562_Human0.82249969
109SOX2_16153702_ChIP-ChIP_HESCs_Human0.81844385
110* NANOG_16153702_ChIP-ChIP_HESCs_Human0.81746564
111CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.81713278
112FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.81204987
113TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81027993
114* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.80897998
115OCT4_18692474_ChIP-Seq_MEFs_Mouse0.79413241
116TET1_21451524_ChIP-Seq_MESCs_Mouse0.78666108
117TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.77667897
118SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.77247087
119SOX2_18555785_ChIP-Seq_MESCs_Mouse0.76379557

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.26275482
2MP0003693_abnormal_embryo_hatching4.23350813
3MP0003806_abnormal_nucleotide_metabolis3.58564053
4MP0004957_abnormal_blastocyst_morpholog3.40565509
5MP0003186_abnormal_redox_activity3.09009066
6MP0006036_abnormal_mitochondrial_physio3.00919517
7MP0010094_abnormal_chromosome_stability2.74724150
8MP0008058_abnormal_DNA_repair2.64418744
9MP0010030_abnormal_orbit_morphology2.53516328
10MP0003077_abnormal_cell_cycle2.44756850
11MP0002132_abnormal_respiratory_system2.33787673
12MP0003111_abnormal_nucleus_morphology2.27530890
13MP0001835_abnormal_antigen_presentation2.24221831
14MP0002234_abnormal_pharynx_morphology2.22512449
15MP0009333_abnormal_splenocyte_physiolog2.15256770
16MP0006035_abnormal_mitochondrial_morpho2.12384939
17MP0009785_altered_susceptibility_to2.11697877
18MP0001853_heart_inflammation1.98354686
19MP0005671_abnormal_response_to1.97127258
20MP0003646_muscle_fatigue1.89396383
21MP0003763_abnormal_thymus_physiology1.88189202
22MP0003941_abnormal_skin_development1.86548487
23MP0002396_abnormal_hematopoietic_system1.85049370
24MP0004233_abnormal_muscle_weight1.82958927
25MP0008007_abnormal_cellular_replicative1.82460253
26MP0008932_abnormal_embryonic_tissue1.79731166
27MP0003786_premature_aging1.77795945
28MP0003136_yellow_coat_color1.74581091
29MP0005075_abnormal_melanosome_morpholog1.67577418
30MP0002938_white_spotting1.63812003
31MP0008057_abnormal_DNA_replication1.62560838
32MP0003724_increased_susceptibility_to1.62355755
33MP0002148_abnormal_hypersensitivity_rea1.61934408
34MP0000490_abnormal_crypts_of1.61133968
35MP0001764_abnormal_homeostasis1.55738390
36MP0000685_abnormal_immune_system1.51715207
37MP0003718_maternal_effect1.50860399
38MP0009697_abnormal_copulation1.50578757
39MP0001986_abnormal_taste_sensitivity1.47948185
40MP0001697_abnormal_embryo_size1.44943111
41MP0005025_abnormal_response_to1.44098253
42MP0001661_extended_life_span1.43310963
43MP0002139_abnormal_hepatobiliary_system1.40656132
44MP0002837_dystrophic_cardiac_calcinosis1.37888351
45MP0000689_abnormal_spleen_morphology1.37381482
46MP0001672_abnormal_embryogenesis/_devel1.35289002
47MP0005380_embryogenesis_phenotype1.35289002
48MP0003937_abnormal_limbs/digits/tail_de1.34867626
49MP0002398_abnormal_bone_marrow1.33439764
50MP0001293_anophthalmia1.31832637
51MP0002722_abnormal_immune_system1.29827317
52MP0006292_abnormal_olfactory_placode1.28566094
53MP0000537_abnormal_urethra_morphology1.28471637
54MP0001800_abnormal_humoral_immune1.27879994
55MP0002080_prenatal_lethality1.26710043
56MP0002085_abnormal_embryonic_tissue1.23255626
57MP0005000_abnormal_immune_tolerance1.21935399
58MP0002420_abnormal_adaptive_immunity1.20277853
59MP0003656_abnormal_erythrocyte_physiolo1.19787879
60MP0002723_abnormal_immune_serum1.19428697
61MP0001819_abnormal_immune_cell1.18548685
62MP0002429_abnormal_blood_cell1.18427029
63MP0000372_irregular_coat_pigmentation1.18003745
64MP0005451_abnormal_body_composition1.16813717
65MP0003984_embryonic_growth_retardation1.16176772
66MP0001346_abnormal_lacrimal_gland1.15040082
67MP0002084_abnormal_developmental_patter1.14572982
68MP0003123_paternal_imprinting1.14413982
69MP0002019_abnormal_tumor_incidence1.14297488
70MP0002452_abnormal_antigen_presenting1.13907605
71MP0000716_abnormal_immune_system1.12852656
72MP0005501_abnormal_skin_physiology1.12817344
73MP0002088_abnormal_embryonic_growth/wei1.11021851
74MP0008789_abnormal_olfactory_epithelium1.10317046
75MP0000313_abnormal_cell_death1.10238126
76MP0003436_decreased_susceptibility_to1.09967071
77MP0000358_abnormal_cell_content/1.09329055
78MP0002210_abnormal_sex_determination1.09318754
79MP0008469_abnormal_protein_level1.08547467
80MP0005379_endocrine/exocrine_gland_phen1.08066903
81MP0000749_muscle_degeneration1.07562763
82MP0002405_respiratory_system_inflammati1.06808787
83MP0001727_abnormal_embryo_implantation1.06493957
84MP0000343_altered_response_to1.06374408
85MP0004147_increased_porphyrin_level1.04079488
86MP0004084_abnormal_cardiac_muscle1.02129923
87MP0006082_CNS_inflammation1.01932410
88MP0010307_abnormal_tumor_latency1.00086129
89MP0002697_abnormal_eye_size0.98379058
90MP0000703_abnormal_thymus_morphology0.98267405
91MP0000858_altered_metastatic_potential0.98113523
92MP0009672_abnormal_birth_weight0.97683798
93MP0005266_abnormal_metabolism0.96705930
94MP0002095_abnormal_skin_pigmentation0.96134130
95MP0006072_abnormal_retinal_apoptosis0.95369232
96MP0005330_cardiomyopathy0.95004007
97MP0005397_hematopoietic_system_phenotyp0.94715312
98MP0001545_abnormal_hematopoietic_system0.94715312
99MP0003195_calcinosis0.94467513
100MP0000049_abnormal_middle_ear0.93410853
101MP0005408_hypopigmentation0.92260699
102MP0002419_abnormal_innate_immunity0.91796279
103MP0008004_abnormal_stomach_pH0.91726372
104MP0001929_abnormal_gametogenesis0.91056539
105MP0001845_abnormal_inflammatory_respons0.90672392
106MP0001529_abnormal_vocalization0.90122689
107MP0001145_abnormal_male_reproductive0.89802029
108MP0001919_abnormal_reproductive_system0.89787034
109MP0005319_abnormal_enzyme/_coenzyme0.88225641
110MP0005464_abnormal_platelet_physiology0.86431586
111MP0004808_abnormal_hematopoietic_stem0.86338358
112MP0002111_abnormal_tail_morphology0.85156840
113MP0005636_abnormal_mineral_homeostasis0.84563842
114MP0000750_abnormal_muscle_regeneration0.84335399
115MP0002254_reproductive_system_inflammat0.83777673
116MP0004215_abnormal_myocardial_fiber0.83264491
117MP0001790_abnormal_immune_system0.82172307
118MP0005387_immune_system_phenotype0.82172307
119MP0001286_abnormal_eye_development0.81835079
120MP0010155_abnormal_intestine_physiology0.81814145
121MP0005332_abnormal_amino_acid0.81257301
122MP0002233_abnormal_nose_morphology0.80158012
123MP0002163_abnormal_gland_morphology0.79449917
124MP0000653_abnormal_sex_gland0.79154393
125MP0002277_abnormal_respiratory_mucosa0.77453232
126MP0000350_abnormal_cell_proliferation0.77373713
127MP0009053_abnormal_anal_canal0.77145348
128MP0006054_spinal_hemorrhage0.76431487
129MP0001730_embryonic_growth_arrest0.76318097
130MP0005376_homeostasis/metabolism_phenot0.76030198
131MP0005394_taste/olfaction_phenotype0.74532028
132MP0005499_abnormal_olfactory_system0.74532028
133MP0002796_impaired_skin_barrier0.74356257
134MP0003567_abnormal_fetal_cardiomyocyte0.73774321
135MP0002933_joint_inflammation0.73683628
136MP0001873_stomach_inflammation0.73133444
137MP0000647_abnormal_sebaceous_gland0.72576198
138MP0005174_abnormal_tail_pigmentation0.72288294
139MP0003890_abnormal_embryonic-extraembry0.71547168
140MP0002653_abnormal_ependyma_morphology0.71252862
141MP0005389_reproductive_system_phenotype0.70588397
142MP0002160_abnormal_reproductive_system0.69980068
143MP0002086_abnormal_extraembryonic_tissu0.69941081
144MP0004197_abnormal_fetal_growth/weight/0.69916176
145MP0000678_abnormal_parathyroid_gland0.69908338
146MP0000465_gastrointestinal_hemorrhage0.69382864
147MP0003315_abnormal_perineum_morphology0.69035148
148MP0003221_abnormal_cardiomyocyte_apopto0.68910289
149MP0001881_abnormal_mammary_gland0.67783193
150MP0008875_abnormal_xenobiotic_pharmacok0.67502683
151MP0005084_abnormal_gallbladder_morpholo0.66946879
152MP0002269_muscular_atrophy0.66819826
153MP0002102_abnormal_ear_morphology0.66692223
154MP0002006_tumorigenesis0.66553161
155MP0005083_abnormal_biliary_tract0.65553891
156MP0010234_abnormal_vibrissa_follicle0.65091134
157MP0003385_abnormal_body_wall0.64912924
158MP0003137_abnormal_impulse_conducting0.64748185
159MP0000747_muscle_weakness0.61731340
160MP0000762_abnormal_tongue_morphology0.61688796
161MP0004145_abnormal_muscle_electrophysio0.61339022

Predicted human phenotypes

RankGene SetZ-score
1Abnormal activity of mitochondrial respiratory chain (HP:0011922)5.60379570
2Decreased activity of mitochondrial respiratory chain (HP:0008972)5.60379570
3Abnormality of cells of the erythroid lineage (HP:0012130)5.50127861
4Abnormal number of erythroid precursors (HP:0012131)5.21665828
5Acute necrotizing encephalopathy (HP:0006965)5.13823692
6Mitochondrial inheritance (HP:0001427)5.05529330
7Hepatocellular necrosis (HP:0001404)4.97514398
8Abnormal mitochondria in muscle tissue (HP:0008316)4.85913917
9Hepatic necrosis (HP:0002605)4.82892528
10Reticulocytopenia (HP:0001896)4.69414316
11Increased CSF lactate (HP:0002490)4.53063611
12Acute encephalopathy (HP:0006846)4.34422275
13Progressive macrocephaly (HP:0004481)4.20191193
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.12457467
15Increased hepatocellular lipid droplets (HP:0006565)4.10144189
16Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.93520200
17Lipid accumulation in hepatocytes (HP:0006561)3.90999113
18Increased intramyocellular lipid droplets (HP:0012240)3.73272026
19* Increased serum lactate (HP:0002151)3.71308088
203-Methylglutaconic aciduria (HP:0003535)3.65553839
21Macrocytic anemia (HP:0001972)3.57744064
22Pallor (HP:0000980)3.52343486
23* Lactic acidosis (HP:0003128)3.51142624
24Increased muscle lipid content (HP:0009058)3.45020567
25Cerebral edema (HP:0002181)3.40715636
26Exercise intolerance (HP:0003546)3.39848008
27Renal Fanconi syndrome (HP:0001994)3.38687619
28Respiratory failure (HP:0002878)3.28205902
29Exertional dyspnea (HP:0002875)3.20042759
30Aplastic anemia (HP:0001915)3.09414795
31Colon cancer (HP:0003003)3.09355315
32Type I transferrin isoform profile (HP:0003642)2.99763931
33Chromosomal breakage induced by crosslinking agents (HP:0003221)2.92291651
34Oral leukoplakia (HP:0002745)2.73747251
35Aplasia/Hypoplasia of the sacrum (HP:0008517)2.72530083
36Respiratory difficulties (HP:0002880)2.69177981
37Increased serum pyruvate (HP:0003542)2.64745941
38Abnormality of glycolysis (HP:0004366)2.64745941
39Microvesicular hepatic steatosis (HP:0001414)2.61196488
40Thrombocytosis (HP:0001894)2.50504326
41Birth length less than 3rd percentile (HP:0003561)2.44814826
42Testicular atrophy (HP:0000029)2.42646252
43Ragged-red muscle fibers (HP:0003200)2.41949412
44Nausea (HP:0002018)2.40787708
45Multiple enchondromatosis (HP:0005701)2.39778723
46Generalized aminoaciduria (HP:0002909)2.33018023
47CNS demyelination (HP:0007305)2.32407807
48Optic disc pallor (HP:0000543)2.30348894
49Abnormality of the heme biosynthetic pathway (HP:0010472)2.30068134
50Pancytopenia (HP:0001876)2.29186876
51Reduced antithrombin III activity (HP:0001976)2.27852714
52Progressive muscle weakness (HP:0003323)2.26964552
53Breast hypoplasia (HP:0003187)2.26522068
54Abnormality of methionine metabolism (HP:0010901)2.25688098
55Dicarboxylic aciduria (HP:0003215)2.24271650
56Abnormality of dicarboxylic acid metabolism (HP:0010995)2.24271650
57Leukodystrophy (HP:0002415)2.21490780
58Poor head control (HP:0002421)2.21201090
59Rough bone trabeculation (HP:0100670)2.19901456
60* Lethargy (HP:0001254)2.18960641
61Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.18739463
62Abnormal protein N-linked glycosylation (HP:0012347)2.18739463
63Abnormal protein glycosylation (HP:0012346)2.18739463
64Abnormal glycosylation (HP:0012345)2.18739463
65Rhabdomyolysis (HP:0003201)2.17874235
66Neoplasm of the adrenal gland (HP:0100631)2.17295426
67IgM deficiency (HP:0002850)2.16527690
68Muscle fiber atrophy (HP:0100295)2.14389887
69Irregular epiphyses (HP:0010582)2.14177691
70Aplasia/Hypoplasia of the uvula (HP:0010293)2.11949660
71Meckel diverticulum (HP:0002245)2.11783344
72Abnormality of urine glucose concentration (HP:0011016)2.08948566
73Glycosuria (HP:0003076)2.08948566
74Microretrognathia (HP:0000308)2.06842087
7511 pairs of ribs (HP:0000878)2.06259900
76Type 2 muscle fiber atrophy (HP:0003554)2.04203143
77Abnormal hemoglobin (HP:0011902)2.03887441
78Abnormality of the ileum (HP:0001549)2.02044290
79Carpal bone hypoplasia (HP:0001498)2.01186873
80Abnormality of renal resorption (HP:0011038)2.00059353
81Abnormality of alanine metabolism (HP:0010916)1.95319645
82Hyperalaninemia (HP:0003348)1.95319645
83Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.95319645
84Absent thumb (HP:0009777)1.92116252
85Petechiae (HP:0000967)1.91741764
86Emotional lability (HP:0000712)1.88461077
87Elevated erythrocyte sedimentation rate (HP:0003565)1.88328199
88Facial cleft (HP:0002006)1.87714561
89Hyperphosphaturia (HP:0003109)1.87677730
90Double outlet right ventricle (HP:0001719)1.87403151
91Congenital malformation of the right heart (HP:0011723)1.87403151
92Amniotic constriction ring (HP:0009775)1.84323806
93Abnormality of placental membranes (HP:0011409)1.84323806
94Neoplasm of the adrenal cortex (HP:0100641)1.84087856
95Cerebral hypomyelination (HP:0006808)1.82980056
96Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.82812098
97Premature graying of hair (HP:0002216)1.82674722
98Hypoplastic pelvis (HP:0008839)1.81731852
99Abnormality of chromosome stability (HP:0003220)1.77458489
100Abnormality of serum amino acid levels (HP:0003112)1.75188784
101Abnormality of fatty-acid metabolism (HP:0004359)1.75116372
102Abnormality of pyrimidine metabolism (HP:0004353)1.74942573
103Severe combined immunodeficiency (HP:0004430)1.72086492
104Abnormality of reticulocytes (HP:0004312)1.72016295
105Megaloblastic anemia (HP:0001889)1.71161240
106Spastic diplegia (HP:0001264)1.70127373
107Squamous cell carcinoma (HP:0002860)1.67945130
108Abnormality of the anterior horn cell (HP:0006802)1.67395672
109Degeneration of anterior horn cells (HP:0002398)1.67395672
110Gout (HP:0001997)1.67035048
111Trismus (HP:0000211)1.66186622
112Abnormal trabecular bone morphology (HP:0100671)1.65596042
113Methylmalonic aciduria (HP:0012120)1.65536976
114Abnormality of sulfur amino acid metabolism (HP:0004339)1.65316014
115Sclerocornea (HP:0000647)1.65184855
116Horseshoe kidney (HP:0000085)1.64889828
117Sparse eyelashes (HP:0000653)1.64324713
118Hypoglycemic coma (HP:0001325)1.63743227
119Cellular immunodeficiency (HP:0005374)1.63648918
120Selective tooth agenesis (HP:0001592)1.63594894
121Gliosis (HP:0002171)1.62890948
122Ependymoma (HP:0002888)1.62662300
123Opisthotonus (HP:0002179)1.62248486
124Congenital ichthyosiform erythroderma (HP:0007431)1.61950024
125Combined immunodeficiency (HP:0005387)1.60683520
126Palpitations (HP:0001962)1.60591553
127Abnormality of aspartate family amino acid metabolism (HP:0010899)1.60437167
128Chromsome breakage (HP:0040012)1.60251481
129Bone marrow hypocellularity (HP:0005528)1.59743559
130Duplicated collecting system (HP:0000081)1.59623793
131Neutropenia (HP:0001875)1.58663160
132Truncus arteriosus (HP:0001660)1.58405954
133IgG deficiency (HP:0004315)1.58073884
134Hypoplasia of the pons (HP:0012110)1.57670392
135Abnormality of the preputium (HP:0100587)1.55056193

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.85860488
2NME25.23124648
3STK164.24660848
4EIF2AK13.77866712
5BUB13.74502082
6TAF13.11025894
7SMG12.77894313
8NEK12.70407073
9WEE12.67163877
10EIF2AK32.56646602
11BCKDK2.29819297
12MUSK2.17335313
13VRK12.11078956
14SRPK12.06209197
15PIM21.96475888
16NME11.94435026
17TLK11.89267780
18KDR1.82589381
19NUAK11.70597260
20TESK21.69731524
21MAP4K11.62481070
22PBK1.61830349
23MYLK1.61165441
24MAP3K121.58750367
25MAP3K111.54628925
26IRAK31.53433051
27PLK41.51651953
28IRAK41.47876089
29RPS6KB21.42405342
30TXK1.38701685
31MST41.33548298
32BRSK21.23471830
33CSNK1G31.22851480
34ZAK1.20515289
35TRIM281.18923457
36TEC1.18223300
37CDC71.16848540
38CDK81.16024938
39PLK11.08306625
40ILK1.07909723
41CSNK1A1L1.07537262
42CSNK1G11.07378974
43AURKB1.06970830
44AURKA1.01194611
45FLT31.00470972
46DAPK11.00091977
47MKNK10.99240689
48RPS6KA40.98512834
49MAP2K30.97442902
50PASK0.94153282
51ACVR1B0.94141613
52LIMK10.92904020
53EIF2AK20.92266312
54IKBKB0.90978065
55ZAP700.89467371
56TGFBR10.87198768
57MAPKAPK30.85777218
58MAPKAPK50.82518540
59TSSK60.82005382
60TESK10.81352137
61BTK0.80615184
62BLK0.80214247
63LRRK20.78795972
64CDK70.78493698
65CSNK2A10.78441419
66DYRK30.78159165
67TYK20.78077848
68CSNK1G20.77759882
69CCNB10.77469510
70EEF2K0.76024739
71OBSCN0.74546140
72ABL20.73817826
73PIM10.71310725
74TBK10.71092926
75CHEK10.71060305
76IKBKE0.70563401
77SYK0.69020802
78ATR0.68786728
79MKNK20.68526422
80BRAF0.68091108
81KIT0.68038695
82MAP2K60.66439918
83CSNK2A20.65893745
84TTK0.64616990
85MAP4K20.64290703
86MELK0.61916565
87BRSK10.61621452
88PRKCI0.61078734
89ADRBK20.60611889
90PINK10.59087481
91MAP2K70.58655514
92PHKG20.56897244
93PHKG10.56897244
94PRKG20.54568979
95NLK0.54411703
96SCYL20.53021554
97LYN0.52558722
98MAP3K80.52552392
99DYRK20.52276823
100RPS6KA50.52164142
101LATS10.52018614
102JAK30.51395393
103NEK20.51060806
104ATM0.50810696
105PAK40.50184891
106PRKD30.49825395
107MST1R0.49801833
108MAP3K100.49455166
109CDK90.48970242
110PDK20.47920565
111ARAF0.47731254
112PAK10.47688584
113PIK3CG0.47662394
114STK40.46862397
115CDK40.46083017
116AKT20.44460698
117LATS20.43885721
118EPHA20.43694293
119STK38L0.43661866
120PLK30.43495236
121DAPK30.43464885
122MAP3K30.43301428
123GRK70.41740993
124CDK10.39949974
125GRK10.39085614
126WNK30.38058747
127BMPR1B0.37789883
128CHEK20.36804996
129STK240.36141002
130CDK190.35782499
131CDK20.32316471
132CSNK1E0.31181846
133ERBB40.30434069
134STK30.28198809
135LMTK20.25403829

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030105.49641746
2Proteasome_Homo sapiens_hsa030504.09012115
3Oxidative phosphorylation_Homo sapiens_hsa001903.58473546
4DNA replication_Homo sapiens_hsa030303.51992096
5Parkinsons disease_Homo sapiens_hsa050123.37253532
6RNA polymerase_Homo sapiens_hsa030203.25636716
7Mismatch repair_Homo sapiens_hsa034302.86233492
8Pyrimidine metabolism_Homo sapiens_hsa002402.56506422
9Huntingtons disease_Homo sapiens_hsa050162.41016972
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.40143516
11Protein export_Homo sapiens_hsa030602.28006034
12Base excision repair_Homo sapiens_hsa034102.23747407
13Homologous recombination_Homo sapiens_hsa034402.21504656
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.17368214
15Nucleotide excision repair_Homo sapiens_hsa034202.16258500
16Alzheimers disease_Homo sapiens_hsa050102.14918753
17Spliceosome_Homo sapiens_hsa030402.11769330
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.74505751
19RNA transport_Homo sapiens_hsa030131.58760992
20One carbon pool by folate_Homo sapiens_hsa006701.58622054
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.57678119
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.44953550
23Non-homologous end-joining_Homo sapiens_hsa034501.40873144
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38674311
25Folate biosynthesis_Homo sapiens_hsa007901.37531281
26Purine metabolism_Homo sapiens_hsa002301.36750555
27RNA degradation_Homo sapiens_hsa030181.33854728
28Vitamin B6 metabolism_Homo sapiens_hsa007501.28890190
29Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.23884076
30Basal transcription factors_Homo sapiens_hsa030221.23713679
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.23260187
32Fanconi anemia pathway_Homo sapiens_hsa034601.17451465
33Sulfur relay system_Homo sapiens_hsa041221.12946534
34Cardiac muscle contraction_Homo sapiens_hsa042601.08589318
35Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.03330273
36Glutathione metabolism_Homo sapiens_hsa004800.99421254
37Drug metabolism - other enzymes_Homo sapiens_hsa009830.99038964
38Steroid biosynthesis_Homo sapiens_hsa001000.98039031
39Carbon metabolism_Homo sapiens_hsa012000.95329517
40Pentose phosphate pathway_Homo sapiens_hsa000300.92984342
41Cell cycle_Homo sapiens_hsa041100.91943380
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91514287
43Cysteine and methionine metabolism_Homo sapiens_hsa002700.88813184
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86749975
45Primary immunodeficiency_Homo sapiens_hsa053400.79157635
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78950842
47Metabolic pathways_Homo sapiens_hsa011000.77336388
48Biosynthesis of amino acids_Homo sapiens_hsa012300.72123567
49Propanoate metabolism_Homo sapiens_hsa006400.70583185
50p53 signaling pathway_Homo sapiens_hsa041150.66803615
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.66546770
52Pyruvate metabolism_Homo sapiens_hsa006200.64941762
53Epstein-Barr virus infection_Homo sapiens_hsa051690.64867493
54Fatty acid elongation_Homo sapiens_hsa000620.64673069
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64326829
56Selenocompound metabolism_Homo sapiens_hsa004500.62783877
57Graft-versus-host disease_Homo sapiens_hsa053320.62081910
58Antigen processing and presentation_Homo sapiens_hsa046120.60687652
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60641672
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.60487516
61Peroxisome_Homo sapiens_hsa041460.60480574
62Allograft rejection_Homo sapiens_hsa053300.60015645
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59792020
64Fructose and mannose metabolism_Homo sapiens_hsa000510.59302342
65Sulfur metabolism_Homo sapiens_hsa009200.58230423
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57928876
67Fatty acid metabolism_Homo sapiens_hsa012120.57375770
68Arachidonic acid metabolism_Homo sapiens_hsa005900.56806019
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56255347
70Arginine biosynthesis_Homo sapiens_hsa002200.55959795
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54406116
72Systemic lupus erythematosus_Homo sapiens_hsa053220.53383808
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51544371
74Cyanoamino acid metabolism_Homo sapiens_hsa004600.48682107
75Legionellosis_Homo sapiens_hsa051340.47661732
76Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47038739
77Galactose metabolism_Homo sapiens_hsa000520.46835036
78Basal cell carcinoma_Homo sapiens_hsa052170.46142615
79Herpes simplex infection_Homo sapiens_hsa051680.45816735
80Intestinal immune network for IgA production_Homo sapiens_hsa046720.44881729
81Oocyte meiosis_Homo sapiens_hsa041140.43720315
82Other glycan degradation_Homo sapiens_hsa005110.41439336
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40134647
84Arginine and proline metabolism_Homo sapiens_hsa003300.38781700
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.37513910
86N-Glycan biosynthesis_Homo sapiens_hsa005100.36306128
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.35876185
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34667631
89Hematopoietic cell lineage_Homo sapiens_hsa046400.34525156
90Asthma_Homo sapiens_hsa053100.34462100
91Fatty acid degradation_Homo sapiens_hsa000710.33452505
92Measles_Homo sapiens_hsa051620.33179034
93Tryptophan metabolism_Homo sapiens_hsa003800.32906487
94Caffeine metabolism_Homo sapiens_hsa002320.31758266
95Thyroid cancer_Homo sapiens_hsa052160.29471817
96Vibrio cholerae infection_Homo sapiens_hsa051100.27364708
97mRNA surveillance pathway_Homo sapiens_hsa030150.27195482
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.26855795
99Chemical carcinogenesis_Homo sapiens_hsa052040.26451324
100Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.26313231
101Autoimmune thyroid disease_Homo sapiens_hsa053200.26057757
102Alcoholism_Homo sapiens_hsa050340.25926759
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25061564
104NF-kappa B signaling pathway_Homo sapiens_hsa040640.25016842
105Vitamin digestion and absorption_Homo sapiens_hsa049770.23289770
106Tyrosine metabolism_Homo sapiens_hsa003500.20989819
107Lysine degradation_Homo sapiens_hsa003100.20496808
108Phenylalanine metabolism_Homo sapiens_hsa003600.19934097
109Regulation of autophagy_Homo sapiens_hsa041400.19269561
110Hippo signaling pathway_Homo sapiens_hsa043900.18810348
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.17810067
112Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.17598272
113beta-Alanine metabolism_Homo sapiens_hsa004100.16272220
114Apoptosis_Homo sapiens_hsa042100.15700474
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.15112339
116Butanoate metabolism_Homo sapiens_hsa006500.15014075
117Linoleic acid metabolism_Homo sapiens_hsa005910.14686806
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.13962381
119Leishmaniasis_Homo sapiens_hsa051400.13944161
120Hedgehog signaling pathway_Homo sapiens_hsa043400.12126807
121Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.11138531
122Maturity onset diabetes of the young_Homo sapiens_hsa049500.09594114
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.08292542
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.08147359
125Bladder cancer_Homo sapiens_hsa052190.06417585

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