MRPS17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S17P family. The encoded protein is moderately conserved between human mitochondrial and prokaryotic ribosomal proteins. Pseudogenes corresponding to this gene are found on chromosomes 1p, 3p, 6q, 14p, 18q, and Xq. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.09100358
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.54819576
3proteasome assembly (GO:0043248)5.28808746
4ATP synthesis coupled proton transport (GO:0015986)5.22644705
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.22644705
6ribosomal small subunit biogenesis (GO:0042274)5.02737092
7DNA deamination (GO:0045006)5.02259512
8establishment of protein localization to mitochondrial membrane (GO:0090151)4.98387687
9maturation of SSU-rRNA (GO:0030490)4.94438917
10viral transcription (GO:0019083)4.87399494
11translational termination (GO:0006415)4.76639139
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.61837971
13transcription elongation from RNA polymerase III promoter (GO:0006385)4.61206860
14termination of RNA polymerase III transcription (GO:0006386)4.61206860
15SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.48359208
16cotranslational protein targeting to membrane (GO:0006613)4.46157956
17mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.41007587
18mitochondrial respiratory chain complex I assembly (GO:0032981)4.41007587
19NADH dehydrogenase complex assembly (GO:0010257)4.41007587
20protein targeting to ER (GO:0045047)4.37890401
21rRNA modification (GO:0000154)4.33867244
22ribosomal large subunit biogenesis (GO:0042273)4.28928239
23respiratory electron transport chain (GO:0022904)4.26165801
24chaperone-mediated protein transport (GO:0072321)4.25213729
25protein localization to endoplasmic reticulum (GO:0070972)4.21537229
26protein complex biogenesis (GO:0070271)4.18923385
27translational elongation (GO:0006414)4.18647633
28establishment of protein localization to endoplasmic reticulum (GO:0072599)4.14415184
29electron transport chain (GO:0022900)4.14184641
30deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.12284109
31negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.07513677
32water-soluble vitamin biosynthetic process (GO:0042364)4.05871416
33respiratory chain complex IV assembly (GO:0008535)3.92691585
34mitochondrial respiratory chain complex assembly (GO:0033108)3.91639120
35CENP-A containing nucleosome assembly (GO:0034080)3.89655866
36cullin deneddylation (GO:0010388)3.88926553
377-methylguanosine mRNA capping (GO:0006370)3.87220252
38* translation (GO:0006412)3.86588437
39RNA capping (GO:0036260)3.85517865
407-methylguanosine RNA capping (GO:0009452)3.85517865
41GTP biosynthetic process (GO:0006183)3.82190802
42cellular protein complex disassembly (GO:0043624)3.80928440
43protein neddylation (GO:0045116)3.80701703
44L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.80470758
45viral life cycle (GO:0019058)3.77455705
46regulation of mitochondrial translation (GO:0070129)3.76039471
47negative regulation of ligase activity (GO:0051352)3.73506936
48negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.73506936
49rRNA methylation (GO:0031167)3.72453965
50telomere maintenance via semi-conservative replication (GO:0032201)3.72414161
51chromatin remodeling at centromere (GO:0031055)3.71887840
52positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.71718155
53regulation of cellular amino acid metabolic process (GO:0006521)3.70419815
54regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.68396457
55translational initiation (GO:0006413)3.66875996
56pseudouridine synthesis (GO:0001522)3.66704276
57protein deneddylation (GO:0000338)3.66438261
58ribonucleoprotein complex biogenesis (GO:0022613)3.66221745
59cellular component biogenesis (GO:0044085)3.59001301
60guanosine-containing compound biosynthetic process (GO:1901070)3.57012183
61deoxyribose phosphate biosynthetic process (GO:0046385)3.56275748
622-deoxyribonucleotide biosynthetic process (GO:0009265)3.56275748
63nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.55456158
64anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.53283831
65protein-cofactor linkage (GO:0018065)3.49011712
66protein targeting to mitochondrion (GO:0006626)3.47595041
67RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.46210969
68tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.46210969
69DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.46182461
70spliceosomal snRNP assembly (GO:0000387)3.46141755
71signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.39942437
72intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.39942437
73oxidative phosphorylation (GO:0006119)3.39803351
74cytochrome complex assembly (GO:0017004)3.39259370
75signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.39223442
76signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.39223442
77signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.39223442
78establishment of integrated proviral latency (GO:0075713)3.38896867
79rRNA processing (GO:0006364)3.36964005
80antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.33504425
81pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.32864258
82pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.32797473
83CTP metabolic process (GO:0046036)3.29804659
84CTP biosynthetic process (GO:0006241)3.29804659
85deoxyribonucleotide biosynthetic process (GO:0009263)3.28857965
86UTP biosynthetic process (GO:0006228)3.28726588
87deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.27987047
88establishment of protein localization to mitochondrion (GO:0072655)3.27712992
89transcription-coupled nucleotide-excision repair (GO:0006283)3.27582861
90exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.27439748
91nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.25720089
92DNA strand elongation involved in DNA replication (GO:0006271)3.25069921
93signal transduction involved in DNA integrity checkpoint (GO:0072401)3.25010384
94signal transduction involved in DNA damage checkpoint (GO:0072422)3.25010384
95amino acid salvage (GO:0043102)3.23972349
96L-methionine salvage (GO:0071267)3.23972349
97L-methionine biosynthetic process (GO:0071265)3.23972349
98purine nucleobase biosynthetic process (GO:0009113)3.23435683
99signal transduction involved in cell cycle checkpoint (GO:0072395)3.21873060
100peptidyl-histidine modification (GO:0018202)3.21664209
101telomere maintenance via recombination (GO:0000722)3.21217514
102rRNA metabolic process (GO:0016072)3.20251230
103intracellular protein transmembrane import (GO:0044743)3.20152121
104protein complex disassembly (GO:0043241)3.19397123
105maturation of 5.8S rRNA (GO:0000460)3.19376356
106tRNA processing (GO:0008033)3.17668397
107ATP biosynthetic process (GO:0006754)3.16167867
108mitochondrial RNA metabolic process (GO:0000959)3.16130971
109regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.12242558
110regulation of mitotic spindle checkpoint (GO:1903504)3.12242558
111purine nucleoside triphosphate biosynthetic process (GO:0009145)3.10286072
112protein K6-linked ubiquitination (GO:0085020)3.07375298
113protein localization to mitochondrion (GO:0070585)3.06052514
114hydrogen ion transmembrane transport (GO:1902600)3.06006858
115purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.05217950
116replication fork processing (GO:0031297)2.97301805
117DNA double-strand break processing (GO:0000729)2.96074317
118positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.88568622
119ubiquinone biosynthetic process (GO:0006744)2.88220192
120tRNA metabolic process (GO:0006399)2.85244258
121DNA damage response, detection of DNA damage (GO:0042769)2.83203228
122proton transport (GO:0015992)2.83072849
123inner mitochondrial membrane organization (GO:0007007)2.82971141
124positive regulation of ligase activity (GO:0051351)2.77197536
125hydrogen transport (GO:0006818)2.76192012
126mannosylation (GO:0097502)2.74902951
127mitochondrial transport (GO:0006839)2.74756209
128ncRNA processing (GO:0034470)2.73987167
129DNA replication checkpoint (GO:0000076)2.72726382
130ncRNA metabolic process (GO:0034660)2.72609950
131ribonucleoside triphosphate biosynthetic process (GO:0009201)2.72015771

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.07048825
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.37653873
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.16243780
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.08121342
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.05974073
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.80057757
7E2F7_22180533_ChIP-Seq_HELA_Human3.68925592
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.56632786
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.54317268
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.48843496
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.45406375
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.41536170
13* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.32732639
14* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.29075510
15MYC_18358816_ChIP-ChIP_MESCs_Mouse3.04471367
16ELF1_17652178_ChIP-ChIP_JURKAT_Human3.03829686
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.99081222
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.91847195
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.83487183
20VDR_23849224_ChIP-Seq_CD4+_Human2.71828761
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.69425149
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.68413673
23ZNF274_21170338_ChIP-Seq_K562_Hela2.60289600
24MYC_19079543_ChIP-ChIP_MESCs_Mouse2.48179196
25DCP1A_22483619_ChIP-Seq_HELA_Human2.46592477
26THAP11_20581084_ChIP-Seq_MESCs_Mouse2.44419454
27E2F4_17652178_ChIP-ChIP_JURKAT_Human2.43216642
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.31761351
29FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.30178790
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.28963769
31FOXP3_21729870_ChIP-Seq_TREG_Human2.28880385
32ELK1_19687146_ChIP-ChIP_HELA_Human2.28809494
33YY1_21170310_ChIP-Seq_MESCs_Mouse2.24778886
34XRN2_22483619_ChIP-Seq_HELA_Human2.23436756
35VDR_22108803_ChIP-Seq_LS180_Human2.13518575
36NELFA_20434984_ChIP-Seq_ESCs_Mouse2.08467001
37FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.05135246
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97141087
39TTF2_22483619_ChIP-Seq_HELA_Human1.96720440
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.94894917
41ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.94646482
42GABP_19822575_ChIP-Seq_HepG2_Human1.93774053
43* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.92409845
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.89499126
45* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.80342984
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.78431968
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71942798
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.65350842
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.62813054
50ERG_20887958_ChIP-Seq_HPC-7_Mouse1.54176691
51CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.51617540
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.45159893
53RBPJ_22232070_ChIP-Seq_NCS_Mouse1.43391510
54MYC_18940864_ChIP-ChIP_HL60_Human1.42258993
55MYCN_18555785_ChIP-Seq_MESCs_Mouse1.39184846
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.33118505
57CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.32996526
58ELK1_22589737_ChIP-Seq_MCF10A_Human1.32246235
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31671383
60SALL1_21062744_ChIP-ChIP_HESCs_Human1.31495955
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30878297
62PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29775290
63ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28374660
64TP53_22573176_ChIP-Seq_HFKS_Human1.28142973
65ZFX_18555785_ChIP-Seq_MESCs_Mouse1.26871063
66CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.26200950
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24254975
68IRF1_19129219_ChIP-ChIP_H3396_Human1.23217216
69ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.22274044
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21337166
71GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.21159825
72P300_19829295_ChIP-Seq_ESCs_Human1.17193400
73NANOG_18555785_ChIP-Seq_MESCs_Mouse1.16181270
74IGF1R_20145208_ChIP-Seq_DFB_Human1.16163238
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.14657351
76CIITA_25753668_ChIP-Seq_RAJI_Human1.14622333
77FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12609042
78FOXA1_25329375_ChIP-Seq_VCAP_Human1.12609042
79BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12178896
80MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.10028322
81MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09676297
82CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.05512560
83TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05128967
84SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04464994
85NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03989394
86AR_20517297_ChIP-Seq_VCAP_Human1.03309682
87E2F1_21310950_ChIP-Seq_MCF-7_Human1.03139571
88* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02870657
89CTBP2_25329375_ChIP-Seq_LNCAP_Human1.01902443
90CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98692316
91GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97888210
92ER_23166858_ChIP-Seq_MCF-7_Human0.96770997
93SOX2_19829295_ChIP-Seq_ESCs_Human0.96460205
94NANOG_19829295_ChIP-Seq_ESCs_Human0.96460205
95AR_21909140_ChIP-Seq_LNCAP_Human0.95696208
96GBX2_23144817_ChIP-Seq_PC3_Human0.95608858
97GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94162099
98NANOG_16153702_ChIP-ChIP_HESCs_Human0.92610655
99TAF15_26573619_Chip-Seq_HEK293_Human0.91739138
100SOX2_16153702_ChIP-ChIP_HESCs_Human0.91721257
101SOX2_18555785_ChIP-Seq_MESCs_Mouse0.91680218
102HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.91321499
103IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.91147259
104HTT_18923047_ChIP-ChIP_STHdh_Human0.91131089
105CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.91067636
106NCOR_22424771_ChIP-Seq_293T_Human0.89180941
107CTCF_18555785_ChIP-Seq_MESCs_Mouse0.84883507
108* SOX17_20123909_ChIP-Seq_XEN_Mouse0.83882040
109TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.83562463
110KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.83531290
111RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.82595785
112GATA3_21878914_ChIP-Seq_MCF-7_Human0.81899840
113NFE2_27457419_Chip-Seq_LIVER_Mouse0.80485080
114KDM5A_27292631_Chip-Seq_BREAST_Human0.80408005
115FLI1_27457419_Chip-Seq_LIVER_Mouse0.79543545
116HOXB7_26014856_ChIP-Seq_BT474_Human0.79144741
117KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.78583279
118FUS_26573619_Chip-Seq_HEK293_Human0.78189608
119PCGF2_27294783_Chip-Seq_ESCs_Mouse0.78124633
120E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.77996153
121FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77836812
122EZH2_27294783_Chip-Seq_NPCs_Mouse0.77817316
123CBP_20019798_ChIP-Seq_JUKART_Human0.77382614
124IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.77382614
125SPI1_23547873_ChIP-Seq_NB4_Human0.73357327
126PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.69574418
127EWS_26573619_Chip-Seq_HEK293_Human0.69488463
128EGR1_23403033_ChIP-Seq_LIVER_Mouse0.67918537
129SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.66972642
130FOXM1_23109430_ChIP-Seq_U2OS_Human0.66187673
131EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.65863535
132TBX5_21415370_ChIP-Seq_HL-1_Mouse0.65478485
133GATA1_22025678_ChIP-Seq_K562_Human0.65046493
134FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.64683083
135POU5F1_16153702_ChIP-ChIP_HESCs_Human0.63784068
136HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.62259944
137LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.59364239
138CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.58472585

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.03916679
2MP0003693_abnormal_embryo_hatching3.60389632
3MP0008058_abnormal_DNA_repair3.23837802
4MP0004147_increased_porphyrin_level3.22979307
5MP0003806_abnormal_nucleotide_metabolis2.93744017
6MP0001529_abnormal_vocalization2.91557779
7MP0010094_abnormal_chromosome_stability2.86162194
8MP0009697_abnormal_copulation2.72040006
9MP0003186_abnormal_redox_activity2.58805919
10MP0004957_abnormal_blastocyst_morpholog2.54926438
11MP0006036_abnormal_mitochondrial_physio2.44984830
12MP0006072_abnormal_retinal_apoptosis2.39534825
13MP0002837_dystrophic_cardiac_calcinosis2.38782682
14MP0008057_abnormal_DNA_replication2.31990007
15MP0003077_abnormal_cell_cycle2.22575865
16MP0002132_abnormal_respiratory_system2.20835787
17MP0003195_calcinosis2.17431155
18MP0003718_maternal_effect2.16859830
19MP0001188_hyperpigmentation2.13080502
20MP0002638_abnormal_pupillary_reflex2.10841390
21MP0003786_premature_aging2.07649161
22MP0003111_abnormal_nucleus_morphology2.07343677
23MP0006292_abnormal_olfactory_placode2.04412824
24MP0001986_abnormal_taste_sensitivity1.98149601
25MP0001905_abnormal_dopamine_level1.86770569
26MP0008932_abnormal_embryonic_tissue1.85891148
27MP0005551_abnormal_eye_electrophysiolog1.83950955
28MP0000372_irregular_coat_pigmentation1.78809528
29MP0008007_abnormal_cellular_replicative1.75296243
30MP0001764_abnormal_homeostasis1.70787813
31MP0006035_abnormal_mitochondrial_morpho1.70230460
32MP0009046_muscle_twitch1.70207867
33MP0003880_abnormal_central_pattern1.69565759
34MP0000566_synostosis1.67004806
35MP0003136_yellow_coat_color1.64456289
36MP0002163_abnormal_gland_morphology1.61757868
37MP0002396_abnormal_hematopoietic_system1.57845727
38MP0005253_abnormal_eye_physiology1.57116974
39MP0003123_paternal_imprinting1.54162062
40MP0003646_muscle_fatigue1.51080891
41MP0003656_abnormal_erythrocyte_physiolo1.49726884
42MP0002938_white_spotting1.48255864
43MP0005379_endocrine/exocrine_gland_phen1.47114298
44MP0002876_abnormal_thyroid_physiology1.44799419
45MP0002234_abnormal_pharynx_morphology1.40810119
46MP0000427_abnormal_hair_cycle1.30472100
47MP0005332_abnormal_amino_acid1.29386594
48MP0003315_abnormal_perineum_morphology1.25700700
49MP0004142_abnormal_muscle_tone1.24174065
50MP0009745_abnormal_behavioral_response1.22017116
51MP0002102_abnormal_ear_morphology1.21727006
52MP0002095_abnormal_skin_pigmentation1.20645877
53MP0006276_abnormal_autonomic_nervous1.17877819
54MP0005075_abnormal_melanosome_morpholog1.15397582
55MP0001984_abnormal_olfaction1.14955096
56MP0002160_abnormal_reproductive_system1.13205665
57MP0008877_abnormal_DNA_methylation1.12596329
58MP0004145_abnormal_muscle_electrophysio1.03912422
59MP0003787_abnormal_imprinting1.03445511
60MP0005423_abnormal_somatic_nervous1.03126957
61MP0000647_abnormal_sebaceous_gland1.01828225
62MP0001853_heart_inflammation1.01503130
63MP0003941_abnormal_skin_development0.99398507
64MP0005636_abnormal_mineral_homeostasis0.99346157
65MP0005409_darkened_coat_color0.98503753
66MP0002277_abnormal_respiratory_mucosa0.97931792
67MP0000015_abnormal_ear_pigmentation0.97890968
68MP0009785_altered_susceptibility_to0.97583147
69MP0004215_abnormal_myocardial_fiber0.97029875
70MP0002210_abnormal_sex_determination0.96030454
71MP0005408_hypopigmentation0.94653133
72MP0005410_abnormal_fertilization0.94343958
73MP0005084_abnormal_gallbladder_morpholo0.91826364
74MP0005266_abnormal_metabolism0.91143546
75MP0009333_abnormal_splenocyte_physiolog0.90608712
76MP0002736_abnormal_nociception_after0.90087854
77MP0003011_delayed_dark_adaptation0.89225686
78MP0000681_abnormal_thyroid_gland0.87976949
79MP0001919_abnormal_reproductive_system0.87532303
80MP0001485_abnormal_pinna_reflex0.86864628
81MP0005171_absent_coat_pigmentation0.86713184
82MP0002653_abnormal_ependyma_morphology0.86663407
83MP0000490_abnormal_crypts_of0.86605053
84MP0002254_reproductive_system_inflammat0.86069784
85MP0003567_abnormal_fetal_cardiomyocyte0.85928824
86MP0000313_abnormal_cell_death0.85772083
87MP0002148_abnormal_hypersensitivity_rea0.83549265
88MP0003937_abnormal_limbs/digits/tail_de0.82967205
89MP0005646_abnormal_pituitary_gland0.82579472
90MP0005195_abnormal_posterior_eye0.82496592
91MP0008789_abnormal_olfactory_epithelium0.82148821
92MP0005389_reproductive_system_phenotype0.81643141
93MP0008995_early_reproductive_senescence0.80764743
94MP0002090_abnormal_vision0.80613078
95MP0008875_abnormal_xenobiotic_pharmacok0.80544703
96MP0003137_abnormal_impulse_conducting0.80273840
97MP0002693_abnormal_pancreas_physiology0.79399902
98MP0001119_abnormal_female_reproductive0.78869821
99MP0005174_abnormal_tail_pigmentation0.78558178
100MP0001542_abnormal_bone_strength0.77074913
101MP0002751_abnormal_autonomic_nervous0.76845846
102MP0003724_increased_susceptibility_to0.76313491
103MP0003763_abnormal_thymus_physiology0.76305657
104MP0004019_abnormal_vitamin_homeostasis0.76132497
105MP0008872_abnormal_physiological_respon0.75402855
106MP0003698_abnormal_male_reproductive0.74006642
107MP0001145_abnormal_male_reproductive0.73830595
108MP0004885_abnormal_endolymph0.72200462
109MP0003121_genomic_imprinting0.71933293
110MP0001944_abnormal_pancreas_morphology0.71646092
111MP0010386_abnormal_urinary_bladder0.70710151
112MP0000358_abnormal_cell_content/0.70704722
113MP0005645_abnormal_hypothalamus_physiol0.70411097
114MP0000653_abnormal_sex_gland0.70304843
115MP0005376_homeostasis/metabolism_phenot0.69625509
116MP0001929_abnormal_gametogenesis0.68349725
117MP0008260_abnormal_autophagy0.65707344
118MP0000026_abnormal_inner_ear0.63093297
119MP0000631_abnormal_neuroendocrine_gland0.62352466
120MP0001293_anophthalmia0.61849275
121MP0004133_heterotaxia0.61128973
122MP0002272_abnormal_nervous_system0.60462256
123MP0001963_abnormal_hearing_physiology0.60426896
124MP0000689_abnormal_spleen_morphology0.60157039
125MP0001968_abnormal_touch/_nociception0.59673581
126MP0003938_abnormal_ear_development0.56832622
127MP0008004_abnormal_stomach_pH0.56597947
128MP0002398_abnormal_bone_marrow0.55898649
129MP0004381_abnormal_hair_follicle0.55297540
130MP0002735_abnormal_chemical_nociception0.54620336
131MP0002722_abnormal_immune_system0.54254867
132MP0005671_abnormal_response_to0.52010114

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.57602483
2Mitochondrial inheritance (HP:0001427)5.25016150
3Abnormal mitochondria in muscle tissue (HP:0008316)5.03086901
4Hepatocellular necrosis (HP:0001404)4.98638104
5Increased CSF lactate (HP:0002490)4.78413634
6Acute encephalopathy (HP:0006846)4.60585001
7Increased hepatocellular lipid droplets (HP:0006565)4.56147647
8Progressive macrocephaly (HP:0004481)4.52229078
9Hepatic necrosis (HP:0002605)4.45005144
10Abnormality of cells of the erythroid lineage (HP:0012130)4.44980824
11Abnormal number of erythroid precursors (HP:0012131)4.37380603
12Reticulocytopenia (HP:0001896)4.33927812
133-Methylglutaconic aciduria (HP:0003535)4.25872125
14Lipid accumulation in hepatocytes (HP:0006561)4.18401708
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.88587229
16Increased serum lactate (HP:0002151)3.87100356
17Decreased activity of mitochondrial respiratory chain (HP:0008972)3.80380518
18Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.80380518
19Renal Fanconi syndrome (HP:0001994)3.76136698
20Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.70979856
21Lactic acidosis (HP:0003128)3.43299272
22Aplastic anemia (HP:0001915)3.38626671
23Increased serum pyruvate (HP:0003542)3.35635279
24Abnormality of glycolysis (HP:0004366)3.35635279
25Cerebral edema (HP:0002181)3.25041139
26Exercise intolerance (HP:0003546)3.24103327
27Macrocytic anemia (HP:0001972)3.22475580
28Abnormality of midbrain morphology (HP:0002418)3.21130798
29Molar tooth sign on MRI (HP:0002419)3.21130798
30Increased intramyocellular lipid droplets (HP:0012240)3.17177261
31Respiratory failure (HP:0002878)3.08775536
32Microvesicular hepatic steatosis (HP:0001414)3.01389556
33Birth length less than 3rd percentile (HP:0003561)3.00151513
34Pallor (HP:0000980)2.94270422
35Type I transferrin isoform profile (HP:0003642)2.87237761
36Exertional dyspnea (HP:0002875)2.87205771
37Abnormality of the heme biosynthetic pathway (HP:0010472)2.86726680
38Respiratory difficulties (HP:0002880)2.82587196
39Oral leukoplakia (HP:0002745)2.80904151
40Optic disc pallor (HP:0000543)2.74816674
41Increased muscle lipid content (HP:0009058)2.72470196
42Leukodystrophy (HP:0002415)2.63349908
43Aplasia/Hypoplasia of the sacrum (HP:0008517)2.53906026
44Congenital stationary night blindness (HP:0007642)2.42133735
45Pancytopenia (HP:0001876)2.42082306
46Cerebral hypomyelination (HP:0006808)2.40800846
47Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.39838820
48Abnormality of alanine metabolism (HP:0010916)2.39838820
49Hyperalaninemia (HP:0003348)2.39838820
50CNS demyelination (HP:0007305)2.35606479
51Nephronophthisis (HP:0000090)2.31437777
52Rough bone trabeculation (HP:0100670)2.30788044
53Abnormality of renal resorption (HP:0011038)2.27225045
54Hypothermia (HP:0002045)2.26967423
55Reduced antithrombin III activity (HP:0001976)2.23687155
56Abnormal protein glycosylation (HP:0012346)2.22530019
57Abnormal glycosylation (HP:0012345)2.22530019
58Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.22530019
59Abnormal protein N-linked glycosylation (HP:0012347)2.22530019
60Abnormality of serum amino acid levels (HP:0003112)2.19520767
61Lethargy (HP:0001254)2.19146935
62Breast hypoplasia (HP:0003187)2.17121964
63Abnormality of aspartate family amino acid metabolism (HP:0010899)2.14260255
64Abnormality of methionine metabolism (HP:0010901)2.10499469
65Abnormality of the renal cortex (HP:0011035)2.03296342
66Sclerocornea (HP:0000647)2.03113872
67Abnormality of the labia minora (HP:0012880)2.01247551
68Chromsome breakage (HP:0040012)2.00487191
69Medial flaring of the eyebrow (HP:0010747)1.99844755
70Pancreatic fibrosis (HP:0100732)1.98432778
71Pendular nystagmus (HP:0012043)1.97088179
72Abnormality of urine glucose concentration (HP:0011016)1.94756423
73Glycosuria (HP:0003076)1.94756423
74Severe visual impairment (HP:0001141)1.94375861
75Aplasia/hypoplasia of the uterus (HP:0008684)1.93266312
76Absent thumb (HP:0009777)1.92948744
77Abnormality of the ileum (HP:0001549)1.92274982
78Emotional lability (HP:0000712)1.91236386
79Type II lissencephaly (HP:0007260)1.90067758
80Abnormality of the renal medulla (HP:0100957)1.89283665
81Large for gestational age (HP:0001520)1.87531923
82Abnormality of the renal collecting system (HP:0004742)1.87357502
83True hermaphroditism (HP:0010459)1.86977067
84Chromosomal breakage induced by crosslinking agents (HP:0003221)1.86421489
85Hyperphosphaturia (HP:0003109)1.86318116
86Abnormality of the preputium (HP:0100587)1.85582452
87Methylmalonic aciduria (HP:0012120)1.85053300
88Abnormality of vitamin B metabolism (HP:0004340)1.84541440
89Renal tubular dysfunction (HP:0000124)1.84211150
90Furrowed tongue (HP:0000221)1.82888089
91Abnormality of the pons (HP:0007361)1.82764748
92Abnormal rod and cone electroretinograms (HP:0008323)1.82746144
93Type 2 muscle fiber atrophy (HP:0003554)1.82042255
94Pancreatic cysts (HP:0001737)1.80667769
95Duplicated collecting system (HP:0000081)1.80441156
96Hypoplasia of the pons (HP:0012110)1.80396175
97Aplasia/Hypoplasia of the uvula (HP:0010293)1.79888919
98Abnormal hair whorl (HP:0010721)1.78306410
99Premature graying of hair (HP:0002216)1.78288914
100X-linked dominant inheritance (HP:0001423)1.76378629
101Renal cortical cysts (HP:0000803)1.75958377
102Irregular epiphyses (HP:0010582)1.75895315
103Hyperglycinemia (HP:0002154)1.75435406
104Abnormal trabecular bone morphology (HP:0100671)1.75404755
105Abolished electroretinogram (ERG) (HP:0000550)1.75362332
106Ketoacidosis (HP:0001993)1.73264978
107Methylmalonic acidemia (HP:0002912)1.72674557
108CNS hypomyelination (HP:0003429)1.71795543
109Nephrogenic diabetes insipidus (HP:0009806)1.71765912
110Muscle fiber atrophy (HP:0100295)1.71334748
111Cystic liver disease (HP:0006706)1.71110238
112Parakeratosis (HP:0001036)1.69819968
113Meckel diverticulum (HP:0002245)1.69416326
114Colon cancer (HP:0003003)1.68871504
115Microretrognathia (HP:0000308)1.68652877
116Triphalangeal thumb (HP:0001199)1.68444619
117Attenuation of retinal blood vessels (HP:0007843)1.68330387
118Hypoglycemic coma (HP:0001325)1.68289615
119Bile duct proliferation (HP:0001408)1.67954627
120Abnormal biliary tract physiology (HP:0012439)1.67954627
121Abnormality of the vitamin B12 metabolism (HP:0004341)1.67761420
122Congenital primary aphakia (HP:0007707)1.67565485
123Amniotic constriction ring (HP:0009775)1.66929220
124Abnormality of placental membranes (HP:0011409)1.66929220
125Decreased electroretinogram (ERG) amplitude (HP:0000654)1.66748484
126Absent rod-and cone-mediated responses on ERG (HP:0007688)1.66502905
127Neoplasm of the adrenal gland (HP:0100631)1.65040517
128Generalized aminoaciduria (HP:0002909)1.64546372
129Gait imbalance (HP:0002141)1.63218055
130Blindness (HP:0000618)1.62866548
131Sparse eyelashes (HP:0000653)1.62798110
132Gliosis (HP:0002171)1.62675881
133Aplasia/Hypoplasia of the fovea (HP:0008060)1.62276027
134Congenital, generalized hypertrichosis (HP:0004540)1.61464717
135Cellular immunodeficiency (HP:0005374)1.60887775
136Abnormality of the axillary hair (HP:0100134)1.60725347
137Abnormality of secondary sexual hair (HP:0009888)1.60725347
138Patellar aplasia (HP:0006443)1.60397979

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.05879117
2VRK23.86735683
3BUB13.51675424
4EIF2AK13.38609901
5TLK13.21001276
6WEE13.17899121
7NME23.15319005
8NUAK13.01671965
9FRK2.95915675
10SRPK12.75580138
11VRK12.46432236
12NME12.44640961
13TNIK2.44071093
14PBK2.33554873
15BRSK22.22619281
16EIF2AK32.08528556
17CCNB12.06641030
18TRIM282.00266132
19CASK1.96597698
20CDK191.91527283
21WNK31.81466283
22MAP4K21.79303365
23MAP3K121.78190820
24MKNK11.62167106
25INSRR1.58167229
26WNK41.53935176
27ACVR1B1.51665596
28MUSK1.50081795
29TAF11.49068570
30BMPR1B1.46115699
31CDK81.43489540
32PLK41.41240174
33ZAK1.38472088
34MKNK21.34612015
35TESK21.33022837
36EIF2AK21.31189385
37PIM21.29372309
38BRSK11.24444025
39MAP2K71.21382966
40PRPF4B1.15623676
41PDK21.15197886
42PHKG21.11237091
43PHKG11.11237091
44IRAK31.10820294
45MST41.10476685
46PLK11.08656910
47TSSK61.04520893
48MYLK1.02041552
49TEC1.01836441
50LIMK11.00837354
51CDC70.98781298
52FLT30.96635925
53OXSR10.94852804
54DYRK30.93863261
55DYRK20.87344208
56PNCK0.86609861
57AURKA0.84652316
58IRAK40.84591099
59PLK30.83528439
60AURKB0.82801360
61BCR0.81427295
62BCKDK0.81316107
63ADRBK20.79259066
64ATR0.76779725
65OBSCN0.76284700
66BRAF0.74525607
67TXK0.73603760
68STK30.72857546
69CSNK1G20.71906890
70PLK20.71134342
71PAK30.69025190
72CSNK2A10.68933563
73BMPR20.68200644
74CDK70.67901316
75PRKCI0.67216991
76PIK3CG0.66619205
77MAPK130.66610427
78PRKCG0.63937199
79GRK70.63607404
80KIT0.62721107
81STK240.62140997
82TAOK30.60539034
83SIK30.59998549
84RPS6KB20.57843227
85BRD40.56779155
86CSNK2A20.56533882
87MAP3K40.56299008
88YES10.56254914
89CSNK1A1L0.54754385
90PRKCE0.54255714
91ADRBK10.54116201
92TIE10.54100371
93ERBB30.53927412
94ABL20.53926667
95CSNK1G30.52546212
96MAPKAPK50.52354670
97NEK20.52137109
98CHEK20.50746533
99TAOK20.50127412
100TTK0.48774345
101STK40.47690688
102RPS6KA50.46634839
103CAMKK20.45298351
104STK38L0.44241501
105DAPK10.42809510
106NEK60.42749086
107LYN0.42675865
108ATM0.42477102
109BTK0.41575696
110MAP3K110.41114058
111CLK10.41078236
112NEK10.40521580
113PINK10.40186287
114MAPKAPK30.39610294
115CSNK1E0.37346682
116MAPK40.36130916
117RPS6KA40.35723925
118CSNK1A10.35298224
119BLK0.35093954
120TGFBR10.34971872
121GRK10.34874079
122ARAF0.33974906
123CAMK10.33626804
124PASK0.33441502
125NLK0.33386983
126STK390.33284327
127ERBB40.32990018
128ILK0.32963711
129CAMK2B0.32322271
130KDR0.31812017
131CSNK1G10.30098335
132MAP2K60.28881737
133TESK10.28688402
134CAMK2A0.26764099
135CHEK10.26619157
136PRKACA0.26255013

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030104.70674462
2Proteasome_Homo sapiens_hsa030504.16771821
3RNA polymerase_Homo sapiens_hsa030203.76874023
4Oxidative phosphorylation_Homo sapiens_hsa001903.74639636
5Parkinsons disease_Homo sapiens_hsa050123.32898762
6DNA replication_Homo sapiens_hsa030303.28254729
7Mismatch repair_Homo sapiens_hsa034302.90308498
8Protein export_Homo sapiens_hsa030602.78688741
9Pyrimidine metabolism_Homo sapiens_hsa002402.64051353
10Homologous recombination_Homo sapiens_hsa034402.55101492
11Huntingtons disease_Homo sapiens_hsa050162.46588147
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.46400297
13Spliceosome_Homo sapiens_hsa030402.21470550
14Alzheimers disease_Homo sapiens_hsa050102.19160812
15Nucleotide excision repair_Homo sapiens_hsa034202.18918416
16Base excision repair_Homo sapiens_hsa034102.03238709
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.87014915
18Non-homologous end-joining_Homo sapiens_hsa034501.84480445
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.71693691
20Caffeine metabolism_Homo sapiens_hsa002321.67110007
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.66810866
22Basal transcription factors_Homo sapiens_hsa030221.65061098
23Purine metabolism_Homo sapiens_hsa002301.59459738
24RNA transport_Homo sapiens_hsa030131.55803583
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.53377767
26Fanconi anemia pathway_Homo sapiens_hsa034601.50649698
27Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.50614050
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.44337486
29One carbon pool by folate_Homo sapiens_hsa006701.44115628
30RNA degradation_Homo sapiens_hsa030181.33531145
31Butanoate metabolism_Homo sapiens_hsa006501.32874455
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.28434550
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17177337
34Fatty acid elongation_Homo sapiens_hsa000621.12933700
35Tryptophan metabolism_Homo sapiens_hsa003801.09362472
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.08940423
37Cardiac muscle contraction_Homo sapiens_hsa042601.06851366
38Cell cycle_Homo sapiens_hsa041101.06509300
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.04201305
40Folate biosynthesis_Homo sapiens_hsa007901.04102990
41Nitrogen metabolism_Homo sapiens_hsa009101.03009251
42SNARE interactions in vesicular transport_Homo sapiens_hsa041300.95594999
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.95135380
44Glutathione metabolism_Homo sapiens_hsa004800.92807627
45Sulfur relay system_Homo sapiens_hsa041220.92084328
46Cysteine and methionine metabolism_Homo sapiens_hsa002700.89721662
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.89016062
48Metabolic pathways_Homo sapiens_hsa011000.84921181
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.82990570
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79495606
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78846897
52Primary bile acid biosynthesis_Homo sapiens_hsa001200.77338452
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.73947844
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70891920
55Arachidonic acid metabolism_Homo sapiens_hsa005900.69890461
56Steroid biosynthesis_Homo sapiens_hsa001000.64070486
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63603961
58Systemic lupus erythematosus_Homo sapiens_hsa053220.63453216
59Peroxisome_Homo sapiens_hsa041460.63264310
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61550309
61Pyruvate metabolism_Homo sapiens_hsa006200.61087747
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60690880
63Epstein-Barr virus infection_Homo sapiens_hsa051690.60539033
64Fatty acid degradation_Homo sapiens_hsa000710.59457076
65Pentose phosphate pathway_Homo sapiens_hsa000300.57808795
66Collecting duct acid secretion_Homo sapiens_hsa049660.57170104
67mRNA surveillance pathway_Homo sapiens_hsa030150.56718893
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56616610
69Carbon metabolism_Homo sapiens_hsa012000.55342711
70Propanoate metabolism_Homo sapiens_hsa006400.53783886
71Sulfur metabolism_Homo sapiens_hsa009200.51505531
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49711353
73Chemical carcinogenesis_Homo sapiens_hsa052040.47865450
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44598610
75Mineral absorption_Homo sapiens_hsa049780.44130392
76Fatty acid metabolism_Homo sapiens_hsa012120.42772253
77Nicotine addiction_Homo sapiens_hsa050330.40944434
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40077890
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37659594
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35972655
81N-Glycan biosynthesis_Homo sapiens_hsa005100.35966496
82Vibrio cholerae infection_Homo sapiens_hsa051100.34822324
83Biosynthesis of amino acids_Homo sapiens_hsa012300.34775906
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33826104
85Vitamin B6 metabolism_Homo sapiens_hsa007500.33378294
86Regulation of autophagy_Homo sapiens_hsa041400.33043862
87p53 signaling pathway_Homo sapiens_hsa041150.32463490
88Arginine and proline metabolism_Homo sapiens_hsa003300.32340480
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.32137455
90Vitamin digestion and absorption_Homo sapiens_hsa049770.31188143
91Olfactory transduction_Homo sapiens_hsa047400.30247943
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29917855
93Oocyte meiosis_Homo sapiens_hsa041140.29735500
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.29530611
95Allograft rejection_Homo sapiens_hsa053300.29528260
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28428352
97Primary immunodeficiency_Homo sapiens_hsa053400.27843308
98Retinol metabolism_Homo sapiens_hsa008300.27790815
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.27487701
100Herpes simplex infection_Homo sapiens_hsa051680.27107885
101Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.26987670
102Linoleic acid metabolism_Homo sapiens_hsa005910.26005145
103Selenocompound metabolism_Homo sapiens_hsa004500.25602457
104Taste transduction_Homo sapiens_hsa047420.25460590
105Phototransduction_Homo sapiens_hsa047440.25288196
106Galactose metabolism_Homo sapiens_hsa000520.24996682
107beta-Alanine metabolism_Homo sapiens_hsa004100.24954884
108Fat digestion and absorption_Homo sapiens_hsa049750.24587129
109Phenylalanine metabolism_Homo sapiens_hsa003600.24204891
110Tyrosine metabolism_Homo sapiens_hsa003500.23721498
111Rheumatoid arthritis_Homo sapiens_hsa053230.23490257
112Fructose and mannose metabolism_Homo sapiens_hsa000510.21879954
1132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.21469230
114Pentose and glucuronate interconversions_Homo sapiens_hsa000400.20610463
115Autoimmune thyroid disease_Homo sapiens_hsa053200.20086103
116Legionellosis_Homo sapiens_hsa051340.19771234
117Alcoholism_Homo sapiens_hsa050340.19729175
118Ether lipid metabolism_Homo sapiens_hsa005650.19559884
119Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.19335507
120Histidine metabolism_Homo sapiens_hsa003400.18348585
121Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.18213248

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