ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	6.12282574
2	fucose catabolic process (GO:0019317)	4.69492300
3	L-fucose metabolic process (GO:0042354)	4.69492300
4	L-fucose catabolic process (GO:0042355)	4.69492300
5	response to pheromone (GO:0019236)	4.44654599
6	kynurenine metabolic process (GO:0070189)	3.93585464
7	indole-containing compound catabolic process (GO:0042436)	3.93542375
8	indolalkylamine catabolic process (GO:0046218)	3.93542375
9	tryptophan catabolic process (GO:0006569)	3.93542375
10	indolalkylamine metabolic process (GO:0006586)	3.92067631
11	DNA deamination (GO:0045006)	3.85133348
12	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.59906168
13	cAMP catabolic process (GO:0006198)	3.57735634
14	cellular ketone body metabolic process (GO:0046950)	3.55182503
15	water-soluble vitamin biosynthetic process (GO:0042364)	3.46734567
16	tryptophan metabolic process (GO:0006568)	3.46222985
17	detection of light stimulus involved in sensory perception (GO:0050962)	3.46190806
18	detection of light stimulus involved in visual perception (GO:0050908)	3.46190806
19	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.42203816
20	platelet dense granule organization (GO:0060155)	3.36889141
21	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.31640240
22	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.31640240
23	NADH dehydrogenase complex assembly (GO:0010257)	3.31640240
24	protein complex biogenesis (GO:0070271)	3.31239772
25	cyclic nucleotide catabolic process (GO:0009214)	3.24445952
26	negative regulation of telomere maintenance (GO:0032205)	3.21898705
27	piRNA metabolic process (GO:0034587)	3.18812375
28	ketone body metabolic process (GO:1902224)	3.17177892
29	indole-containing compound metabolic process (GO:0042430)	3.13595023
30	axoneme assembly (GO:0035082)	3.07126552
31	mitochondrial respiratory chain complex assembly (GO:0033108)	3.01730128
32	negative regulation of mast cell activation (GO:0033004)	3.00624826
33	respiratory chain complex IV assembly (GO:0008535)	2.99234698
34	epithelial cilium movement (GO:0003351)	2.99122925
35	gamma-aminobutyric acid transport (GO:0015812)	2.96556590
36	synaptic transmission, cholinergic (GO:0007271)	2.95670899
37	primary amino compound metabolic process (GO:1901160)	2.95125399
38	neuronal action potential (GO:0019228)	2.91976750
39	amine catabolic process (GO:0009310)	2.90438809
40	cellular biogenic amine catabolic process (GO:0042402)	2.90438809
41	sulfation (GO:0051923)	2.84093020
42	serotonin metabolic process (GO:0042428)	2.83659347
43	pyrimidine nucleobase catabolic process (GO:0006208)	2.81766923
44	preassembly of GPI anchor in ER membrane (GO:0016254)	2.79805727
45	protein localization to cilium (GO:0061512)	2.79320518
46	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.78287293
47	retinal cone cell development (GO:0046549)	2.75950455
48	protein polyglutamylation (GO:0018095)	2.73302350
49	behavioral response to ethanol (GO:0048149)	2.72862897
50	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.72130162
51	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.71782674
52	cytochrome complex assembly (GO:0017004)	2.69627838
53	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.68706715
54	replication fork processing (GO:0031297)	2.68149542
55	cilium morphogenesis (GO:0060271)	2.68147268
56	regulation of action potential (GO:0098900)	2.66423187
57	nephron epithelium morphogenesis (GO:0072088)	2.66400197
58	nephron tubule morphogenesis (GO:0072078)	2.66400197
59	nonmotile primary cilium assembly (GO:0035058)	2.65894389
60	rhodopsin mediated signaling pathway (GO:0016056)	2.64555569
61	somite development (GO:0061053)	2.64274978
62	photoreceptor cell development (GO:0042461)	2.63548324
63	cilium organization (GO:0044782)	2.62550499
64	kidney morphogenesis (GO:0060993)	2.61958713
65	protein-cofactor linkage (GO:0018065)	2.61752477
66	neural tube formation (GO:0001841)	2.61502226
67	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.60331075
68	neuronal action potential propagation (GO:0019227)	2.60272140
69	mannosylation (GO:0097502)	2.58407662
70	reflex (GO:0060004)	2.58052904
71	dopamine transport (GO:0015872)	2.57995924
72	rRNA catabolic process (GO:0016075)	2.55494740
73	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.54482429
74	cornea development in camera-type eye (GO:0061303)	2.54398601
75	adaptation of signaling pathway (GO:0023058)	2.53372485
76	photoreceptor cell maintenance (GO:0045494)	2.53350691
77	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.53315797
78	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.52884894
79	transmission of nerve impulse (GO:0019226)	2.52841381
80	positive regulation of fatty acid transport (GO:2000193)	2.52440560
81	reciprocal DNA recombination (GO:0035825)	2.52234012
82	reciprocal meiotic recombination (GO:0007131)	2.52234012
83	nucleobase catabolic process (GO:0046113)	2.51476451
84	multicellular organism reproduction (GO:0032504)	2.50706021
85	spinal cord motor neuron differentiation (GO:0021522)	2.49746152
86	DNA methylation involved in gamete generation (GO:0043046)	2.49614119
87	positive regulation of prostaglandin secretion (GO:0032308)	2.49246131
88	fucosylation (GO:0036065)	2.49204097
89	auditory receptor cell stereocilium organization (GO:0060088)	2.48092815
90	cilium assembly (GO:0042384)	2.47731206
91	regulation of telomere maintenance (GO:0032204)	2.46909149
92	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.46750073
93	S-adenosylmethionine metabolic process (GO:0046500)	2.45328754
94	cilium movement (GO:0003341)	2.44822940
95	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.43965357
96	aromatic amino acid family catabolic process (GO:0009074)	2.43688199
97	glycerophospholipid catabolic process (GO:0046475)	2.43304006
98	ATP synthesis coupled proton transport (GO:0015986)	2.43243489
99	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.43243489
100	startle response (GO:0001964)	2.40243564

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.03676825
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.30899275
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.30188891
4	VDR_22108803_ChIP-Seq_LS180_Human	2.99397765
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.98070644
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.66852474
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.54000681
8	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.31301097
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.27539399
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.26106224
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.22348054
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.20059467
13	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.16209038
14	EWS_26573619_Chip-Seq_HEK293_Human	2.02151009
15	FUS_26573619_Chip-Seq_HEK293_Human	1.98820269
16	P300_19829295_ChIP-Seq_ESCs_Human	1.97526071
17	TAF15_26573619_Chip-Seq_HEK293_Human	1.94968038
18	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.94733593
19	ER_23166858_ChIP-Seq_MCF-7_Human	1.91316946
20	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.81188093
21	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.78496168
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.76003298
23	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.63991932
24	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.63604366
25	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.62321428
26	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.60712050
27	IRF1_19129219_ChIP-ChIP_H3396_Human	1.58000182
28	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.57286741
29	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.55145749
30	BCAT_22108803_ChIP-Seq_LS180_Human	1.55041394
31	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.54794171
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.52345408
33	STAT3_23295773_ChIP-Seq_U87_Human	1.45897390
34	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.45698953
35	REST_21632747_ChIP-Seq_MESCs_Mouse	1.43839201
36	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.42541718
37	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.42231453
38	CBP_20019798_ChIP-Seq_JUKART_Human	1.42231453
39	AR_25329375_ChIP-Seq_VCAP_Human	1.41886140
40	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.41413107
41	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.41413107
42	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.40166032
43	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.40150037
44	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.38859723
45	SMAD4_21799915_ChIP-Seq_A2780_Human	1.38632715
46	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.38531403
47	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.37208695
48	TCF4_23295773_ChIP-Seq_U87_Human	1.36861067
49	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.35968544
50	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.35885389
51	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.35132640
52	SOX2_19829295_ChIP-Seq_ESCs_Human	1.34345201
53	NANOG_19829295_ChIP-Seq_ESCs_Human	1.34345201
54	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.34187172
55	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.33798042
56	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.32705896
57	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.32266664
58	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.32266664
59	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.31390291
60	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.30077708
61	MYC_18940864_ChIP-ChIP_HL60_Human	1.27391332
62	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.26188455
63	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.26129320
64	TCF4_22108803_ChIP-Seq_LS180_Human	1.25755677
65	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.23319427
66	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.20638208
67	AR_20517297_ChIP-Seq_VCAP_Human	1.18152624
68	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.17922860
69	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.17888458
70	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.17690098
71	RUNX2_22187159_ChIP-Seq_PCA_Human	1.17378376
72	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.16143620
73	RNF2_27304074_Chip-Seq_NSC_Mouse	1.15626185
74	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.15521389
75	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.13505875
76	NCOR_22424771_ChIP-Seq_293T_Human	1.12673797
77	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.11084150
78	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.10252224
79	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.09210403
80	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.08308654
81	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.07485525
82	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.07417757
83	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.07294221
84	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.06666333
85	HOXB7_26014856_ChIP-Seq_BT474_Human	1.05332146
86	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.04328545
87	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.00305192
88	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.99318500
89	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.99217621
90	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.98946736
91	P53_22387025_ChIP-Seq_ESCs_Mouse	0.98498079
92	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.98468191
93	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.98353154
94	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.94101536
95	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.92957075
96	AR_21572438_ChIP-Seq_LNCaP_Human	0.92153569
97	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.91750038
98	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.91623174
99	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.91147673
100	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.91094969

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	2.92981691
2	MP0003195_calcinosis	2.80739566
3	MP0008877_abnormal_DNA_methylation	2.78413695
4	MP0005551_abnormal_eye_electrophysiolog	2.61697436
5	MP0001968_abnormal_touch/_nociception	2.40941284
6	MP0006292_abnormal_olfactory_placode	2.40511941
7	MP0002837_dystrophic_cardiac_calcinosis	2.37773000
8	MP0002102_abnormal_ear_morphology	2.32775844
9	MP0003011_delayed_dark_adaptation	2.15314231
10	MP0005646_abnormal_pituitary_gland	2.09795988
11	MP0006072_abnormal_retinal_apoptosis	2.07402115
12	MP0009745_abnormal_behavioral_response	2.06594114
13	MP0009046_muscle_twitch	2.05408008
14	MP0002736_abnormal_nociception_after	1.99768244
15	MP0008872_abnormal_physiological_respon	1.95089099
16	MP0000569_abnormal_digit_pigmentation	1.93776611
17	MP0004142_abnormal_muscle_tone	1.91667926
18	MP0002876_abnormal_thyroid_physiology	1.91546816
19	MP0008875_abnormal_xenobiotic_pharmacok	1.90700583
20	MP0005645_abnormal_hypothalamus_physiol	1.88497924
21	MP0003646_muscle_fatigue	1.87319571
22	MP0003787_abnormal_imprinting	1.83553335
23	MP0002638_abnormal_pupillary_reflex	1.79119518
24	MP0005253_abnormal_eye_physiology	1.78893710
25	MP0000372_irregular_coat_pigmentation	1.76986863
26	MP0004147_increased_porphyrin_level	1.76080761
27	MP0004043_abnormal_pH_regulation	1.68532198
28	MP0001986_abnormal_taste_sensitivity	1.68472960
29	MP0002272_abnormal_nervous_system	1.66470400
30	MP0004885_abnormal_endolymph	1.65181303
31	MP0001501_abnormal_sleep_pattern	1.63050537
32	MP0001485_abnormal_pinna_reflex	1.61604337
33	MP0003880_abnormal_central_pattern	1.59203655
34	MP0002653_abnormal_ependyma_morphology	1.55258991
35	MP0004133_heterotaxia	1.53917314
36	MP0000631_abnormal_neuroendocrine_gland	1.52899149
37	MP0005084_abnormal_gallbladder_morpholo	1.46257820
38	MP0005174_abnormal_tail_pigmentation	1.46107782
39	MP0001486_abnormal_startle_reflex	1.43905705
40	MP0000427_abnormal_hair_cycle	1.39339640
41	MP0002064_seizures	1.38349580
42	MP0006276_abnormal_autonomic_nervous	1.37945129
43	MP0002160_abnormal_reproductive_system	1.35928796
44	MP0002938_white_spotting	1.34306341
45	MP0005389_reproductive_system_phenotype	1.32267820
46	MP0001529_abnormal_vocalization	1.31733251
47	MP0002234_abnormal_pharynx_morphology	1.31142476
48	MP0002557_abnormal_social/conspecific_i	1.31065100
49	MP0002572_abnormal_emotion/affect_behav	1.29309313
50	MP0004145_abnormal_muscle_electrophysio	1.26404286
51	MP0002733_abnormal_thermal_nociception	1.22038730
52	MP0005075_abnormal_melanosome_morpholog	1.19453742
53	MP0001919_abnormal_reproductive_system	1.19029905
54	MP0001970_abnormal_pain_threshold	1.18686492
55	MP0004742_abnormal_vestibular_system	1.16630147
56	MP0010386_abnormal_urinary_bladder	1.14976581
57	MP0005386_behavior/neurological_phenoty	1.13847107
58	MP0004924_abnormal_behavior	1.13847107
59	MP0002095_abnormal_skin_pigmentation	1.13274109
60	MP0002067_abnormal_sensory_capabilities	1.12809238
61	MP0002928_abnormal_bile_duct	1.12795759
62	MP0002277_abnormal_respiratory_mucosa	1.10934591
63	MP0005377_hearing/vestibular/ear_phenot	1.10876811
64	MP0003878_abnormal_ear_physiology	1.10876811
65	MP0003283_abnormal_digestive_organ	1.08686205
66	MP0002735_abnormal_chemical_nociception	1.08012616
67	MP0005195_abnormal_posterior_eye	1.07599106
68	MP0002138_abnormal_hepatobiliary_system	1.05871054
69	MP0001984_abnormal_olfaction	1.04479290
70	MP0003635_abnormal_synaptic_transmissio	1.03136896
71	MP0005410_abnormal_fertilization	1.02175527
72	MP0003252_abnormal_bile_duct	1.01456684
73	MP0002751_abnormal_autonomic_nervous	0.99757270
74	MP0000383_abnormal_hair_follicle	0.98600943
75	MP0005085_abnormal_gallbladder_physiolo	0.97927066
76	MP0001905_abnormal_dopamine_level	0.97490549
77	MP0001324_abnormal_eye_pigmentation	0.95317688
78	MP0002752_abnormal_somatic_nervous	0.93345000
79	MP0005423_abnormal_somatic_nervous	0.93254280
80	MP0002063_abnormal_learning/memory/cond	0.92713227
81	MP0000230_abnormal_systemic_arterial	0.91029273
82	MP0002909_abnormal_adrenal_gland	0.90809617
83	MP0005379_endocrine/exocrine_gland_phen	0.88984616
84	MP0000026_abnormal_inner_ear	0.88797928
85	MP0002163_abnormal_gland_morphology	0.88101756
86	MP0001502_abnormal_circadian_rhythm	0.87830538
87	MP0002693_abnormal_pancreas_physiology	0.83486080
88	MP0004215_abnormal_myocardial_fiber	0.82592914
89	MP0005365_abnormal_bile_salt	0.82505136
90	MP0003121_genomic_imprinting	0.82187437
91	MP0002229_neurodegeneration	0.81352441
92	MP0000778_abnormal_nervous_system	0.81033134
93	MP0008775_abnormal_heart_ventricle	0.80707059
94	MP0003698_abnormal_male_reproductive	0.80232064
95	MP0003718_maternal_effect	0.80164479
96	MP0000538_abnormal_urinary_bladder	0.79716945
97	MP0008789_abnormal_olfactory_epithelium	0.79673259
98	MP0000647_abnormal_sebaceous_gland	0.78785766
99	MP0008058_abnormal_DNA_repair	0.78687081
100	MP0001963_abnormal_hearing_physiology	0.78423178

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.65917617
2	Molar tooth sign on MRI (HP:0002419)	4.27556816
3	Abnormality of midbrain morphology (HP:0002418)	4.27556816
4	Pancreatic fibrosis (HP:0100732)	4.23744493
5	True hermaphroditism (HP:0010459)	3.98484518
6	Congenital stationary night blindness (HP:0007642)	3.81088160
7	Type II lissencephaly (HP:0007260)	3.66508777
8	Nephronophthisis (HP:0000090)	3.60273088
9	Abnormality of the renal cortex (HP:0011035)	3.35405170
10	Abnormality of the renal medulla (HP:0100957)	3.23336991
11	Tubular atrophy (HP:0000092)	2.89838282
12	Cystic liver disease (HP:0006706)	2.82234257
13	Polydipsia (HP:0001959)	2.81962648
14	Abnormal drinking behavior (HP:0030082)	2.81962648
15	Congenital, generalized hypertrichosis (HP:0004540)	2.80725339
16	Abolished electroretinogram (ERG) (HP:0000550)	2.80313651
17	Hyperventilation (HP:0002883)	2.80048894
18	Attenuation of retinal blood vessels (HP:0007843)	2.79544816
19	Pendular nystagmus (HP:0012043)	2.74390364
20	Medial flaring of the eyebrow (HP:0010747)	2.72509087
21	Abnormality of alanine metabolism (HP:0010916)	2.70743278
22	Hyperalaninemia (HP:0003348)	2.70743278
23	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.70743278
24	Agitation (HP:0000713)	2.69911823
25	Chronic hepatic failure (HP:0100626)	2.67668647
26	Concave nail (HP:0001598)	2.64573251
27	Inability to walk (HP:0002540)	2.62504593
28	Absent/shortened dynein arms (HP:0200106)	2.55389083
29	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.55389083
30	Progressive inability to walk (HP:0002505)	2.52016152
31	Abnormal biliary tract physiology (HP:0012439)	2.45623348
32	Bile duct proliferation (HP:0001408)	2.45623348
33	Lissencephaly (HP:0001339)	2.39033336
34	Sclerocornea (HP:0000647)	2.38149275
35	Increased corneal curvature (HP:0100692)	2.34783425
36	Keratoconus (HP:0000563)	2.34783425
37	Gaze-evoked nystagmus (HP:0000640)	2.33748016
38	Cerebellar dysplasia (HP:0007033)	2.32482786
39	Progressive cerebellar ataxia (HP:0002073)	2.31412192
40	Polyuria (HP:0000103)	2.31070294
41	Renal cortical cysts (HP:0000803)	2.30141446
42	Mitochondrial inheritance (HP:0001427)	2.27134398
43	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.26427383
44	Bilateral microphthalmos (HP:0007633)	2.25092225
45	Congenital hepatic fibrosis (HP:0002612)	2.24885229
46	Increased CSF lactate (HP:0002490)	2.22611975
47	Abnormal rod and cone electroretinograms (HP:0008323)	2.22284388
48	Anencephaly (HP:0002323)	2.20555142
49	Optic nerve hypoplasia (HP:0000609)	2.19162982
50	Large for gestational age (HP:0001520)	2.18854137
51	Acute necrotizing encephalopathy (HP:0006965)	2.17456560
52	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.17028399
53	Chorioretinal atrophy (HP:0000533)	2.15621379
54	Furrowed tongue (HP:0000221)	2.14054801
55	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.11702117
56	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.10924097
57	Severe muscular hypotonia (HP:0006829)	2.06093695
58	3-Methylglutaconic aciduria (HP:0003535)	2.03618479
59	Gait imbalance (HP:0002141)	2.02620587
60	Broad-based gait (HP:0002136)	2.02198390
61	Protruding tongue (HP:0010808)	2.00403793
62	Decreased central vision (HP:0007663)	1.98886410
63	Abnormal respiratory epithelium morphology (HP:0012253)	1.98623863
64	Abnormal respiratory motile cilium morphology (HP:0005938)	1.98623863
65	Febrile seizures (HP:0002373)	1.98307580
66	Hypothermia (HP:0002045)	1.98304417
67	Optic disc pallor (HP:0000543)	1.97428843
68	Decreased circulating renin level (HP:0003351)	1.96639522
69	Acute encephalopathy (HP:0006846)	1.96224721
70	Hemiparesis (HP:0001269)	1.96042572
71	Bony spicule pigmentary retinopathy (HP:0007737)	1.94854240
72	Progressive macrocephaly (HP:0004481)	1.94219722
73	Congenital primary aphakia (HP:0007707)	1.93525667
74	Male pseudohermaphroditism (HP:0000037)	1.92729741
75	Thyroid-stimulating hormone excess (HP:0002925)	1.91536947
76	Retinal dysplasia (HP:0007973)	1.91366810
77	Aplasia/hypoplasia of the uterus (HP:0008684)	1.91337597
78	Genetic anticipation (HP:0003743)	1.90177599
79	Patellar aplasia (HP:0006443)	1.89367103
80	Methylmalonic acidemia (HP:0002912)	1.86337613
81	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.85946105
82	Postaxial foot polydactyly (HP:0001830)	1.85926583
83	Focal motor seizures (HP:0011153)	1.84556619
84	Hepatocellular necrosis (HP:0001404)	1.82766491
85	Pachygyria (HP:0001302)	1.82530028
86	Hypomagnesemia (HP:0002917)	1.81880064
87	Abnormality of the pons (HP:0007361)	1.81731152
88	Abnormal urine output (HP:0012590)	1.81414652
89	Intestinal atresia (HP:0011100)	1.80865960
90	Nephrogenic diabetes insipidus (HP:0009806)	1.79998359
91	Short tibia (HP:0005736)	1.79989724
92	Methylmalonic aciduria (HP:0012120)	1.79909344
93	Hypoplasia of the pons (HP:0012110)	1.79563436
94	Aplasia/Hypoplasia of the patella (HP:0006498)	1.79360679
95	Congenital sensorineural hearing impairment (HP:0008527)	1.78897185
96	Stomach cancer (HP:0012126)	1.78653833
97	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.78235863
98	Abnormal mitochondria in muscle tissue (HP:0008316)	1.77101740
99	Tachypnea (HP:0002789)	1.77076107
100	Lipid accumulation in hepatocytes (HP:0006561)	1.76685872

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.51858794
2	ADRBK2	3.32398055
3	BMPR1B	3.00680243
4	MAP4K2	2.88756532
5	ZAK	2.53700953
6	GRK1	2.52807624
7	TLK1	2.50230360
8	WNK3	2.49125685
9	ACVR1B	2.46392703
10	WNK4	2.43513650
11	PINK1	2.35949781
12	MAPK13	2.14037580
13	NUAK1	2.05568398
14	TXK	1.97019994
15	OXSR1	1.95439235
16	CASK	1.91925593
17	CAMKK2	1.73952691
18	TAOK3	1.69188871
19	PNCK	1.61855953
20	INSRR	1.53352434
21	STK39	1.47587924
22	MAP3K4	1.44487588
23	DYRK2	1.24867891
24	ADRBK1	1.22501895
25	DAPK2	1.19827711
26	TGFBR1	1.15441489
27	PAK3	1.09849864
28	MKNK2	1.08725305
29	VRK1	1.08623291
30	VRK2	1.05125118
31	BCKDK	1.02928822
32	TRIM28	1.02326121
33	TAF1	0.98784825
34	PHKG1	0.93325896
35	PHKG2	0.93325896
36	PRKCG	0.92888983
37	MUSK	0.91841357
38	NTRK2	0.91615572
39	PRKCE	0.90447006
40	MARK1	0.89372608
41	TIE1	0.88985888
42	IRAK1	0.85234047
43	NTRK3	0.84927113
44	MAP2K7	0.83886850
45	EPHA4	0.82892399
46	MAPKAPK5	0.81707590
47	TEC	0.81184926
48	MAPK15	0.80011958
49	NEK2	0.79572863
50	CSNK1G2	0.79190652
51	CDK19	0.78062933
52	TNIK	0.76611983
53	PLK2	0.72466006
54	CSNK1G1	0.71500156
55	WEE1	0.68993572
56	MAPKAPK3	0.68537498
57	CSNK1G3	0.67788688
58	FGFR2	0.66580394
59	IKBKB	0.66095393
60	MKNK1	0.65960381
61	PRKCI	0.65717884
62	STK11	0.64035958
63	KIT	0.63164044
64	CSNK1A1L	0.61990939
65	PTK2B	0.60762147
66	PRKCQ	0.58813806
67	SIK2	0.58198995
68	MAP2K6	0.57263000
69	BCR	0.56820571
70	STK38L	0.56423874
71	PIK3CA	0.54516723
72	BRSK2	0.54248420
73	CHUK	0.52148220
74	GRK7	0.51984781
75	CAMK2A	0.49140909
76	EPHA3	0.48733635
77	NME1	0.48587321
78	PRKACA	0.48378668
79	CAMK1	0.47894476
80	PLK3	0.47610191
81	PKN1	0.47497464
82	EIF2AK3	0.46297783
83	ITK	0.45992043
84	GRK5	0.45762613
85	RPS6KA5	0.44705651
86	MST4	0.43231391
87	NLK	0.42523307
88	SYK	0.38507712
89	FLT3	0.37620229
90	CSNK1A1	0.36654165
91	DYRK1A	0.36623256
92	CAMKK1	0.35877220
93	PRKCZ	0.33814388
94	PRKCA	0.33728226
95	PRKCH	0.32954980
96	ERBB2	0.31917363
97	STK3	0.31756079
98	PLK4	0.29798590
99	PRKAA2	0.29174319
100	FER	0.29055522

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.76828762
2	Linoleic acid metabolism_Homo sapiens_hsa00591	2.75928070
3	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.71285367
4	Nitrogen metabolism_Homo sapiens_hsa00910	2.61323417
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.37418864
6	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.19744232
7	Butanoate metabolism_Homo sapiens_hsa00650	2.10836093
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.07946435
9	Caffeine metabolism_Homo sapiens_hsa00232	2.00217553
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.99858282
11	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.99520004
12	Selenocompound metabolism_Homo sapiens_hsa00450	1.97150106
13	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.95670405
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.92734827
15	Tryptophan metabolism_Homo sapiens_hsa00380	1.92280434
16	Nicotine addiction_Homo sapiens_hsa05033	1.91195903
17	Ether lipid metabolism_Homo sapiens_hsa00565	1.90095920
18	RNA polymerase_Homo sapiens_hsa03020	1.87074980
19	Protein export_Homo sapiens_hsa03060	1.85445079
20	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.77366723
21	Parkinsons disease_Homo sapiens_hsa05012	1.76962131
22	Homologous recombination_Homo sapiens_hsa03440	1.71944344
23	Basal transcription factors_Homo sapiens_hsa03022	1.69114475
24	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.62260537
25	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.57224280
26	Morphine addiction_Homo sapiens_hsa05032	1.50391480
27	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.44259782
28	Olfactory transduction_Homo sapiens_hsa04740	1.43116955
29	Fanconi anemia pathway_Homo sapiens_hsa03460	1.41675293
30	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.37803043
31	Taste transduction_Homo sapiens_hsa04742	1.37168266
32	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.33745046
33	Propanoate metabolism_Homo sapiens_hsa00640	1.25330816
34	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.23175261
35	Huntingtons disease_Homo sapiens_hsa05016	1.22120858
36	Asthma_Homo sapiens_hsa05310	1.21807930
37	Chemical carcinogenesis_Homo sapiens_hsa05204	1.20509846
38	Peroxisome_Homo sapiens_hsa04146	1.17252331
39	Cardiac muscle contraction_Homo sapiens_hsa04260	1.16491014
40	RNA degradation_Homo sapiens_hsa03018	1.14304374
41	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.10521266
42	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.09543929
43	Alzheimers disease_Homo sapiens_hsa05010	1.08722318
44	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.08118883
45	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.06048837
46	One carbon pool by folate_Homo sapiens_hsa00670	1.05504394
47	Regulation of autophagy_Homo sapiens_hsa04140	1.03114288
48	Collecting duct acid secretion_Homo sapiens_hsa04966	1.00727599
49	Retinol metabolism_Homo sapiens_hsa00830	0.99162730
50	ABC transporters_Homo sapiens_hsa02010	0.97880863
51	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.95836470
52	Insulin secretion_Homo sapiens_hsa04911	0.95206217
53	Serotonergic synapse_Homo sapiens_hsa04726	0.91373668
54	Type I diabetes mellitus_Homo sapiens_hsa04940	0.89906570
55	Glutamatergic synapse_Homo sapiens_hsa04724	0.89782314
56	Sulfur metabolism_Homo sapiens_hsa00920	0.89615856
57	Circadian entrainment_Homo sapiens_hsa04713	0.88627435
58	Primary immunodeficiency_Homo sapiens_hsa05340	0.86171249
59	Graft-versus-host disease_Homo sapiens_hsa05332	0.85208196
60	Glycerolipid metabolism_Homo sapiens_hsa00561	0.84948519
61	GABAergic synapse_Homo sapiens_hsa04727	0.84429908
62	Purine metabolism_Homo sapiens_hsa00230	0.81853148
63	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.78822378
64	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.78780062
65	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.77312732
66	beta-Alanine metabolism_Homo sapiens_hsa00410	0.74395554
67	Proteasome_Homo sapiens_hsa03050	0.74234481
68	Fat digestion and absorption_Homo sapiens_hsa04975	0.71430076
69	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.71217448
70	Allograft rejection_Homo sapiens_hsa05330	0.69022780
71	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.66355588
72	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.65942126
73	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.63921713
74	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.63546334
75	Salivary secretion_Homo sapiens_hsa04970	0.62716865
76	Histidine metabolism_Homo sapiens_hsa00340	0.61930139
77	Calcium signaling pathway_Homo sapiens_hsa04020	0.60756922
78	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.57918090
79	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.56954178
80	Metabolic pathways_Homo sapiens_hsa01100	0.56653164
81	Rheumatoid arthritis_Homo sapiens_hsa05323	0.53730802
82	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.51323428
83	Ribosome_Homo sapiens_hsa03010	0.50523257
84	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.48777753
85	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.47354822
86	Mineral absorption_Homo sapiens_hsa04978	0.46949611
87	Circadian rhythm_Homo sapiens_hsa04710	0.44422613
88	Sulfur relay system_Homo sapiens_hsa04122	0.43852206
89	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.42870343
90	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.42464932
91	Pyrimidine metabolism_Homo sapiens_hsa00240	0.41855884
92	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.40808029
93	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.40770834
94	Dopaminergic synapse_Homo sapiens_hsa04728	0.38797591
95	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.38000667
96	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.37981103
97	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.37375891
98	Non-homologous end-joining_Homo sapiens_hsa03450	0.36430599
99	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.35390072
100	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.35233551

MRPS17P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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