MRPS18A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. A pseudogene corresponding to this gene is found on chromosome 3p. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.33260658
2energy coupled proton transport, down electrochemical gradient (GO:0015985)6.77148634
3ATP synthesis coupled proton transport (GO:0015986)6.77148634
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.54125563
5respiratory electron transport chain (GO:0022904)5.99928502
6electron transport chain (GO:0022900)5.84103463
7proteasome assembly (GO:0043248)5.64524718
8regulation of mitochondrial translation (GO:0070129)5.14548300
9oxidative phosphorylation (GO:0006119)4.99873253
10protein complex biogenesis (GO:0070271)4.98855636
11protein neddylation (GO:0045116)4.98141695
12chaperone-mediated protein transport (GO:0072321)4.97482886
13establishment of protein localization to mitochondrial membrane (GO:0090151)4.90632739
14cullin deneddylation (GO:0010388)4.70199418
15mitochondrial respiratory chain complex assembly (GO:0033108)4.68444535
16negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.66623873
17mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.62928930
18mitochondrial respiratory chain complex I assembly (GO:0032981)4.62928930
19NADH dehydrogenase complex assembly (GO:0010257)4.62928930
20regulation of cellular amino acid metabolic process (GO:0006521)4.54968922
21protein deneddylation (GO:0000338)4.46374283
22positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.36783976
23DNA deamination (GO:0045006)4.33080089
24DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.24607412
25negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.20747922
26negative regulation of ligase activity (GO:0051352)4.20747922
27rRNA modification (GO:0000154)4.19412608
28antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:4.19164458
29regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.17419772
30signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.15121724
31intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.15121724
32signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.13880540
33signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.13880540
34signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.13880540
35protein targeting to mitochondrion (GO:0006626)4.09298073
36cytochrome complex assembly (GO:0017004)4.09122099
37transcription elongation from RNA polymerase III promoter (GO:0006385)4.05748440
38termination of RNA polymerase III transcription (GO:0006386)4.05748440
397-methylguanosine mRNA capping (GO:0006370)4.04518023
40NADH metabolic process (GO:0006734)4.04266093
41anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.04013041
42establishment of protein localization to mitochondrion (GO:0072655)4.02517702
43signal transduction involved in DNA integrity checkpoint (GO:0072401)4.00572662
44signal transduction involved in DNA damage checkpoint (GO:0072422)4.00572662
45antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.98112856
46respiratory chain complex IV assembly (GO:0008535)3.97374666
47signal transduction involved in cell cycle checkpoint (GO:0072395)3.96640778
48establishment of integrated proviral latency (GO:0075713)3.94290469
497-methylguanosine RNA capping (GO:0009452)3.94228651
50RNA capping (GO:0036260)3.94228651
51inner mitochondrial membrane organization (GO:0007007)3.92055269
52ribosomal small subunit assembly (GO:0000028)3.81710493
53positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.79915361
54pseudouridine synthesis (GO:0001522)3.79436563
55ATP biosynthetic process (GO:0006754)3.79359653
56L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.75005817
57purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.74242173
58protein localization to mitochondrion (GO:0070585)3.71494195
59purine nucleoside triphosphate biosynthetic process (GO:0009145)3.70538199
60positive regulation of ligase activity (GO:0051351)3.66267672
61deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.64712363
62hydrogen ion transmembrane transport (GO:1902600)3.57797975
63GTP biosynthetic process (GO:0006183)3.56330992
64ribosome assembly (GO:0042255)3.54346236
65tricarboxylic acid cycle (GO:0006099)3.53876177
66establishment of viral latency (GO:0019043)3.52243301
67peptidyl-histidine modification (GO:0018202)3.49515042
68rRNA methylation (GO:0031167)3.47756441
69guanosine-containing compound biosynthetic process (GO:1901070)3.47383268
70spliceosomal snRNP assembly (GO:0000387)3.47077200
71GDP-mannose metabolic process (GO:0019673)3.44798816
72regulation of oxidative phosphorylation (GO:0002082)3.42676347
73formation of translation preinitiation complex (GO:0001731)3.42414392
74DNA strand elongation involved in DNA replication (GO:0006271)3.41088394
75telomere maintenance via semi-conservative replication (GO:0032201)3.40830979
76aerobic respiration (GO:0009060)3.40677331
77chromatin remodeling at centromere (GO:0031055)3.40026150
78CENP-A containing nucleosome assembly (GO:0034080)3.39978568
79ribonucleoside triphosphate biosynthetic process (GO:0009201)3.39928106
80* translation (GO:0006412)3.38830223
81protein maturation by protein folding (GO:0022417)3.38725264
82regulation of cellular amine metabolic process (GO:0033238)3.37290834
83positive regulation of cell cycle arrest (GO:0071158)3.32208202
84mitochondrial transport (GO:0006839)3.27327858
85ribosomal large subunit biogenesis (GO:0042273)3.26600268
86maturation of SSU-rRNA (GO:0030490)3.26597509
87DNA strand elongation (GO:0022616)3.24632300
88regulation of cellular respiration (GO:0043457)3.23993790
89regulation of ubiquitin-protein transferase activity (GO:0051438)3.23644938
90antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.23095702
91negative regulation of protein ubiquitination (GO:0031397)3.21859316
92cellular component biogenesis (GO:0044085)3.21613328
93purine nucleobase biosynthetic process (GO:0009113)3.21062684
94ribosomal small subunit biogenesis (GO:0042274)3.20935340
95RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.20921055
96tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.20921055
97ubiquinone biosynthetic process (GO:0006744)3.19909621
98quinone biosynthetic process (GO:1901663)3.19909621
99mitotic metaphase plate congression (GO:0007080)3.17730042
100IMP biosynthetic process (GO:0006188)3.17468566
101amino acid salvage (GO:0043102)3.17101121
102L-methionine salvage (GO:0071267)3.17101121
103L-methionine biosynthetic process (GO:0071265)3.17101121
104proton transport (GO:0015992)3.15266430
105viral transcription (GO:0019083)3.14891588
106metallo-sulfur cluster assembly (GO:0031163)3.14763588
107iron-sulfur cluster assembly (GO:0016226)3.14763588
108protein-cofactor linkage (GO:0018065)3.14731955
109regulation of ligase activity (GO:0051340)3.14711543
110nucleoside triphosphate biosynthetic process (GO:0009142)3.14514847
111nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.14502610
112exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.12870104
113pteridine-containing compound biosynthetic process (GO:0042559)3.12120357
114nucleobase biosynthetic process (GO:0046112)3.12055125
115UTP biosynthetic process (GO:0006228)3.10505711
116translational termination (GO:0006415)3.09586310
117hydrogen transport (GO:0006818)3.08196174
118DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.07521215
119protein K6-linked ubiquitination (GO:0085020)3.05730691
120positive regulation of mitochondrial fission (GO:0090141)3.04985443
121rRNA processing (GO:0006364)3.04512196
122negative regulation of protein modification by small protein conjugation or removal (GO:1903321)3.03741109
123DNA damage response, detection of DNA damage (GO:0042769)3.01030498
124DNA catabolic process, exonucleolytic (GO:0000738)3.00989744
125DNA replication checkpoint (GO:0000076)2.96338099
126cell cycle G1/S phase transition (GO:0044843)2.93205388
127G1/S transition of mitotic cell cycle (GO:0000082)2.93205388
128rRNA metabolic process (GO:0016072)2.88511884
129maturation of 5.8S rRNA (GO:0000460)2.88304549
130signal transduction in response to DNA damage (GO:0042770)2.87460838

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.06202239
2* JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.64373906
3* GABP_17652178_ChIP-ChIP_JURKAT_Human4.48082131
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.36038278
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.30906777
6ETS1_20019798_ChIP-Seq_JURKAT_Human3.99922339
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.95584343
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.75370722
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.50307782
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.39138798
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.21375672
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.18864455
13* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.16662632
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.14630448
15SRF_21415370_ChIP-Seq_HL-1_Mouse2.91799680
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.90628512
17THAP11_20581084_ChIP-Seq_MESCs_Mouse2.74123639
18PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.72025639
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.71323470
20VDR_23849224_ChIP-Seq_CD4+_Human2.65932373
21* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.62853139
22* YY1_21170310_ChIP-Seq_MESCs_Mouse2.61692633
23DCP1A_22483619_ChIP-Seq_HELA_Human2.55289605
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.48600184
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.46346701
26MYC_19079543_ChIP-ChIP_MESCs_Mouse2.37035494
27FOXP3_21729870_ChIP-Seq_TREG_Human2.19227146
28* GABP_19822575_ChIP-Seq_HepG2_Human2.14226843
29XRN2_22483619_ChIP-Seq_HELA_Human2.14080908
30* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.11123104
31NELFA_20434984_ChIP-Seq_ESCs_Mouse2.04583592
32* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.90419993
33ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.87650345
34ELK1_19687146_ChIP-ChIP_HELA_Human1.85090413
35TTF2_22483619_ChIP-Seq_HELA_Human1.83104834
36* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.82315774
37CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.78521198
38FOXM1_23109430_ChIP-Seq_U2OS_Human1.72975383
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70596765
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.68443795
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.68067060
42* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.65461213
43* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.62281424
44TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.58503806
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.55421133
46* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55172033
47E2F7_22180533_ChIP-Seq_HELA_Human1.51831005
48E2F4_17652178_ChIP-ChIP_JURKAT_Human1.49809730
49ELK1_22589737_ChIP-Seq_MCF10A_Human1.49131156
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48724070
51AR_21909140_ChIP-Seq_LNCAP_Human1.46347892
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.40701741
53SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.40337515
54POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39425528
55E2F1_21310950_ChIP-Seq_MCF-7_Human1.36349974
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.35963216
57CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.35432066
58ERG_20887958_ChIP-Seq_HPC-7_Mouse1.32718784
59FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.31713321
60* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.30015255
61PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.24806718
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22647155
63MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21513715
64ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.19310755
65MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.19277101
66* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16140012
67CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.15330873
68IRF1_19129219_ChIP-ChIP_H3396_Human1.14810718
69* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.14373534
70* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.11918991
71MYC_18940864_ChIP-ChIP_HL60_Human1.08284507
72PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06649956
73CIITA_25753668_ChIP-Seq_RAJI_Human1.05877529
74SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.05453742
75* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05015808
76E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03613904
77HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.03432119
78STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02326320
79HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02299705
80SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01547853
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.00872313
82KDM5A_27292631_Chip-Seq_BREAST_Human0.94953028
83POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93125188
84DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91235617
85EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.90444437
86YY1_22570637_ChIP-Seq_MALME-3M_Human0.87875562
87DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87684617
88* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.86246046
89NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.85985057
90NANOG_16153702_ChIP-ChIP_HESCs_Human0.85974051
91FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82895164
92KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.81402570
93TBX5_21415370_ChIP-Seq_HL-1_Mouse0.81179967
94FOXP1_21924763_ChIP-Seq_HESCs_Human0.81114024
95SOX2_18555785_ChIP-Seq_MESCs_Mouse0.79564314
96GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79416505
97TFEB_21752829_ChIP-Seq_HELA_Human0.79112121
98SOX17_20123909_ChIP-Seq_XEN_Mouse0.78434907
99PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.77186343
100HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.75357201
101PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.73818037
102STAT1_20625510_ChIP-Seq_HELA_Human0.73129454
103NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.73072764
104SOX2_18692474_ChIP-Seq_MEFs_Mouse0.72790682
105TET1_21451524_ChIP-Seq_MESCs_Mouse0.72615137
106* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.72602104
107CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.72485526
108EGR1_23403033_ChIP-Seq_LIVER_Mouse0.72305569
109CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.71875178
110* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.71737947
111ELF5_23300383_ChIP-Seq_T47D_Human0.71613939
112SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.71493200
113KLF4_18555785_ChIP-Seq_MESCs_Mouse0.70870915
114OCT4_18692474_ChIP-Seq_MEFs_Mouse0.70732994
115TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.70285077
116SOX2_16153702_ChIP-ChIP_HESCs_Human0.69296253

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue3.80970389
2MP0006036_abnormal_mitochondrial_physio3.76259452
3MP0003693_abnormal_embryo_hatching3.44715533
4MP0006035_abnormal_mitochondrial_morpho3.11377546
5MP0002837_dystrophic_cardiac_calcinosis3.06271440
6MP0003186_abnormal_redox_activity2.96041724
7MP0003806_abnormal_nucleotide_metabolis2.66940672
8MP0001529_abnormal_vocalization2.60481534
9MP0001986_abnormal_taste_sensitivity2.58469300
10MP0004957_abnormal_blastocyst_morpholog2.48128655
11MP0008007_abnormal_cellular_replicative2.41485438
12MP0002876_abnormal_thyroid_physiology2.34852157
13MP0003718_maternal_effect2.17513279
14MP0000749_muscle_degeneration2.06155461
15MP0002736_abnormal_nociception_after1.95008354
16MP0001905_abnormal_dopamine_level1.94765687
17MP0009697_abnormal_copulation1.91689807
18MP0004084_abnormal_cardiac_muscle1.84222726
19MP0001764_abnormal_homeostasis1.80383935
20MP0008932_abnormal_embryonic_tissue1.74273127
21MP0009379_abnormal_foot_pigmentation1.72181946
22MP0004036_abnormal_muscle_relaxation1.71899613
23MP0006072_abnormal_retinal_apoptosis1.70915537
24MP0010094_abnormal_chromosome_stability1.70404120
25MP0006276_abnormal_autonomic_nervous1.69786920
26MP0002163_abnormal_gland_morphology1.69002825
27MP0002938_white_spotting1.65767549
28MP0000751_myopathy1.65044008
29MP0003195_calcinosis1.61611772
30MP0005330_cardiomyopathy1.59463096
31MP0008058_abnormal_DNA_repair1.59392974
32MP0005075_abnormal_melanosome_morpholog1.58237927
33MP0003880_abnormal_central_pattern1.58195117
34MP0000372_irregular_coat_pigmentation1.58126160
35MP0002735_abnormal_chemical_nociception1.56233940
36MP0004215_abnormal_myocardial_fiber1.55725020
37MP0000358_abnormal_cell_content/1.54454171
38MP0000750_abnormal_muscle_regeneration1.53475505
39MP0002102_abnormal_ear_morphology1.52594706
40MP0004145_abnormal_muscle_electrophysio1.51526600
41MP0003077_abnormal_cell_cycle1.48419564
42MP0001968_abnormal_touch/_nociception1.48103600
43MP0008877_abnormal_DNA_methylation1.47605674
44MP0005646_abnormal_pituitary_gland1.47224960
45MP0010030_abnormal_orbit_morphology1.44576743
46MP0003786_premature_aging1.42113488
47MP0009046_muscle_twitch1.37085150
48MP0004142_abnormal_muscle_tone1.36291070
49MP0006292_abnormal_olfactory_placode1.34991693
50MP0008789_abnormal_olfactory_epithelium1.34397764
51MP0005408_hypopigmentation1.32793419
52MP0002132_abnormal_respiratory_system1.31577148
53MP0002638_abnormal_pupillary_reflex1.29708118
54MP0008260_abnormal_autophagy1.29366677
55MP0008057_abnormal_DNA_replication1.28971487
56MP0002148_abnormal_hypersensitivity_rea1.28790721
57MP0003111_abnormal_nucleus_morphology1.24495419
58MP0003136_yellow_coat_color1.23571613
59MP0008995_early_reproductive_senescence1.23367580
60MP0001661_extended_life_span1.21549167
61MP0005266_abnormal_metabolism1.21292711
62MP0003011_delayed_dark_adaptation1.21146752
63MP0002234_abnormal_pharynx_morphology1.19723504
64MP0005332_abnormal_amino_acid1.18688611
65MP0002332_abnormal_exercise_endurance1.14004496
66MP0005084_abnormal_gallbladder_morpholo1.13454678
67MP0003137_abnormal_impulse_conducting1.12957780
68MP0005636_abnormal_mineral_homeostasis1.10543097
69MP0001853_heart_inflammation1.09866902
70MP0005171_absent_coat_pigmentation1.06509516
71MP0009333_abnormal_splenocyte_physiolog1.04530051
72MP0001730_embryonic_growth_arrest1.04526065
73MP0008875_abnormal_xenobiotic_pharmacok1.03794628
74MP0005379_endocrine/exocrine_gland_phen1.03442654
75MP0003941_abnormal_skin_development1.02425217
76MP0003567_abnormal_fetal_cardiomyocyte1.00644765
77MP0002210_abnormal_sex_determination1.00109362
78MP0002106_abnormal_muscle_physiology0.99788659
79MP0001970_abnormal_pain_threshold0.98609428
80MP0001727_abnormal_embryo_implantation0.98560785
81MP0004147_increased_porphyrin_level0.98300605
82MP0003221_abnormal_cardiomyocyte_apopto0.97872512
83MP0002160_abnormal_reproductive_system0.96970234
84MP0004133_heterotaxia0.95499775
85MP0002090_abnormal_vision0.94224318
86MP0000350_abnormal_cell_proliferation0.93903435
87MP0005376_homeostasis/metabolism_phenot0.93205160
88MP0001440_abnormal_grooming_behavior0.93043680
89MP0002277_abnormal_respiratory_mucosa0.92797234
90MP0000313_abnormal_cell_death0.92280865
91MP0009785_altered_susceptibility_to0.91668442
92MP0001929_abnormal_gametogenesis0.89138080
93MP0001881_abnormal_mammary_gland0.88420821
94MP0005584_abnormal_enzyme/coenzyme_acti0.87992613
95MP0001697_abnormal_embryo_size0.87576689
96MP0000343_altered_response_to0.87262700
97MP0001293_anophthalmia0.86860161
98MP0005385_cardiovascular_system_phenoty0.86290454
99MP0001544_abnormal_cardiovascular_syste0.86290454
100MP0002751_abnormal_autonomic_nervous0.86095122
101MP0001542_abnormal_bone_strength0.85869760
102MP0005670_abnormal_white_adipose0.85281367
103MP0002269_muscular_atrophy0.84857451
104MP0002972_abnormal_cardiac_muscle0.84657141
105MP0002064_seizures0.84412611
106MP0003879_abnormal_hair_cell0.84202548
107MP0003656_abnormal_erythrocyte_physiolo0.83584954
108MP0005369_muscle_phenotype0.82970847
109MP0002272_abnormal_nervous_system0.82733543
110MP0005253_abnormal_eye_physiology0.82447573
111MP0008872_abnormal_physiological_respon0.82076242
112MP0005645_abnormal_hypothalamus_physiol0.81634832
113MP0005395_other_phenotype0.79667830
114MP0004043_abnormal_pH_regulation0.79447185
115MP0002822_catalepsy0.79091568
116MP0002254_reproductive_system_inflammat0.78331331
117MP0003315_abnormal_perineum_morphology0.78058746
118MP0000653_abnormal_sex_gland0.78021969
119MP0002095_abnormal_skin_pigmentation0.77912001
120MP0001145_abnormal_male_reproductive0.77751000
121MP0002733_abnormal_thermal_nociception0.77447339
122MP0002080_prenatal_lethality0.77431295
123MP0001756_abnormal_urination0.74959665
124MP0005501_abnormal_skin_physiology0.74566779
125MP0005389_reproductive_system_phenotype0.74042723
126MP0001835_abnormal_antigen_presentation0.73259912
127MP0002019_abnormal_tumor_incidence0.72797863
128MP0005410_abnormal_fertilization0.72224863
129MP0005380_embryogenesis_phenotype0.72115063
130MP0001672_abnormal_embryogenesis/_devel0.72115063
131MP0005620_abnormal_muscle_contractility0.69201107
132MP0002909_abnormal_adrenal_gland0.68596970
133MP0005319_abnormal_enzyme/_coenzyme0.68191630
134MP0005386_behavior/neurological_phenoty0.67507759
135MP0004924_abnormal_behavior0.67507759
136MP0003123_paternal_imprinting0.67374787
137MP0002734_abnormal_mechanical_nocicepti0.67202282
138MP0005499_abnormal_olfactory_system0.67102812
139MP0005394_taste/olfaction_phenotype0.67102812
140MP0002067_abnormal_sensory_capabilities0.66942983
141MP0002127_abnormal_cardiovascular_syste0.66118560
142MP0005083_abnormal_biliary_tract0.65806204
143MP0005058_abnormal_lysosome_morphology0.65229493
144MP0001119_abnormal_female_reproductive0.62629649
145MP0001324_abnormal_eye_pigmentation0.62607048
146MP0005551_abnormal_eye_electrophysiolog0.60660833
147MP0000516_abnormal_urinary_system0.58825643
148MP0005367_renal/urinary_system_phenotyp0.58825643

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.94602502
2Abnormal mitochondria in muscle tissue (HP:0008316)6.41928236
3Mitochondrial inheritance (HP:0001427)6.26149075
4Acute encephalopathy (HP:0006846)5.94127938
5Hepatocellular necrosis (HP:0001404)5.92774711
6Increased CSF lactate (HP:0002490)5.65258384
7Progressive macrocephaly (HP:0004481)5.62904604
8Hepatic necrosis (HP:0002605)5.51957639
9Increased hepatocellular lipid droplets (HP:0006565)4.64750991
10Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.47551305
11Lipid accumulation in hepatocytes (HP:0006561)4.32760133
12Cerebral edema (HP:0002181)4.25494558
133-Methylglutaconic aciduria (HP:0003535)4.22768168
14Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.21231576
15Decreased activity of mitochondrial respiratory chain (HP:0008972)4.21231576
16Increased serum lactate (HP:0002151)4.18801705
17Lactic acidosis (HP:0003128)4.13323910
18Increased serum pyruvate (HP:0003542)4.11075611
19Abnormality of glycolysis (HP:0004366)4.11075611
20Muscle abnormality related to mitochondrial dysfunction (HP:0003800)4.04816419
21Exercise intolerance (HP:0003546)4.03838998
22Renal Fanconi syndrome (HP:0001994)3.95538854
23Respiratory failure (HP:0002878)3.84699165
24Increased intramyocellular lipid droplets (HP:0012240)3.78144858
25Neuroendocrine neoplasm (HP:0100634)3.57107097
26Optic disc pallor (HP:0000543)3.47460122
27Increased muscle lipid content (HP:0009058)3.41103062
28Exertional dyspnea (HP:0002875)3.39869083
29Pheochromocytoma (HP:0002666)3.29549026
30Leukodystrophy (HP:0002415)3.14950643
31CNS demyelination (HP:0007305)3.09521925
32Respiratory difficulties (HP:0002880)3.06630707
33Emotional lability (HP:0000712)2.80373297
34Microvesicular hepatic steatosis (HP:0001414)2.75088180
35Lethargy (HP:0001254)2.74956337
36Abnormality of renal resorption (HP:0011038)2.71567645
37Abnormality of cells of the erythroid lineage (HP:0012130)2.67334862
38Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.64784076
39Abnormal protein N-linked glycosylation (HP:0012347)2.64784076
40Abnormal protein glycosylation (HP:0012346)2.64784076
41Abnormal glycosylation (HP:0012345)2.64784076
42Palpitations (HP:0001962)2.52857959
43Aplasia/Hypoplasia of the sacrum (HP:0008517)2.50083525
44Reduced antithrombin III activity (HP:0001976)2.46465915
45Colon cancer (HP:0003003)2.46178127
46Abnormal number of erythroid precursors (HP:0012131)2.41316499
47Glycosuria (HP:0003076)2.39612720
48Abnormality of urine glucose concentration (HP:0011016)2.39612720
49Type I transferrin isoform profile (HP:0003642)2.38718940
50Abnormality of methionine metabolism (HP:0010901)2.38234598
51Abnormality of the anterior horn cell (HP:0006802)2.36661138
52Degeneration of anterior horn cells (HP:0002398)2.36661138
53Cerebral hypomyelination (HP:0006808)2.35686836
54Methylmalonic aciduria (HP:0012120)2.34797795
55Dicarboxylic aciduria (HP:0003215)2.32515076
56Abnormality of dicarboxylic acid metabolism (HP:0010995)2.32515076
57Abnormality of alanine metabolism (HP:0010916)2.29234728
58Hyperalaninemia (HP:0003348)2.29234728
59Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.29234728
60Generalized aminoaciduria (HP:0002909)2.28425723
61Progressive external ophthalmoplegia (HP:0000590)2.27374236
62Carpal bone hypoplasia (HP:0001498)2.25736638
63Hypoglycemic coma (HP:0001325)2.21399398
64Cholecystitis (HP:0001082)2.20080109
65Abnormal gallbladder physiology (HP:0012438)2.20080109
66Abnormality of aromatic amino acid family metabolism (HP:0004338)2.18776829
67Gliosis (HP:0002171)2.13742238
68Progressive muscle weakness (HP:0003323)2.12841550
69Hyperglycinemia (HP:0002154)2.12699394
70Hyperinsulinemic hypoglycemia (HP:0000825)2.06349141
71Reticulocytopenia (HP:0001896)2.05369667
72Meckel diverticulum (HP:0002245)2.05069397
73Chromosomal breakage induced by crosslinking agents (HP:0003221)2.03630329
74Nausea (HP:0002018)2.02097813
75Abnormality of the preputium (HP:0100587)2.00565761
76Hypoglycemic seizures (HP:0002173)2.00416284
77Nephrogenic diabetes insipidus (HP:0009806)1.99851178
78Sparse eyelashes (HP:0000653)1.98844300
79Birth length less than 3rd percentile (HP:0003561)1.98162855
80Vomiting (HP:0002013)1.97453462
81Chromsome breakage (HP:0040012)1.95306447
82Breast hypoplasia (HP:0003187)1.94694080
83Abnormality of the ileum (HP:0001549)1.93654791
84Hyperphosphaturia (HP:0003109)1.92707456
85Abnormality of aspartate family amino acid metabolism (HP:0010899)1.92616205
86Unsteady gait (HP:0002317)1.92278525
87X-linked dominant inheritance (HP:0001423)1.91906775
88Poor suck (HP:0002033)1.90460960
89Aplastic anemia (HP:0001915)1.89185305
90Esophageal neoplasm (HP:0100751)1.89003984
91Neoplasm of head and neck (HP:0012288)1.89003984
92Abnormality of the labia minora (HP:0012880)1.87307979
93Macrocytic anemia (HP:0001972)1.86705887
94Medial flaring of the eyebrow (HP:0010747)1.86523006
95Secondary amenorrhea (HP:0000869)1.85886486
96Abnormal pupillary function (HP:0007686)1.85372930
97Abnormality of fatty-acid metabolism (HP:0004359)1.85327097
98Renal tubular dysfunction (HP:0000124)1.84257036
99Ragged-red muscle fibers (HP:0003200)1.83555524
100Myotonia (HP:0002486)1.83028597
101Cleft eyelid (HP:0000625)1.82517588
102Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.81123441
103Rough bone trabeculation (HP:0100670)1.80418982
104Abnormality of serum amino acid levels (HP:0003112)1.80348465
105Blindness (HP:0000618)1.79752797
106Abnormal lung lobation (HP:0002101)1.78085191
107Aplasia/hypoplasia of the uterus (HP:0008684)1.77927645
108Pancreatic islet-cell hyperplasia (HP:0004510)1.77887569
109Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.75985677
110Methylmalonic acidemia (HP:0002912)1.75718119
111Neoplasm of the adrenal gland (HP:0100631)1.74544957
112Neoplasm of the peripheral nervous system (HP:0100007)1.70448468
113Congenital primary aphakia (HP:0007707)1.69757453
114Ketoacidosis (HP:0001993)1.68447056
115Type 2 muscle fiber atrophy (HP:0003554)1.67766287
116Rhabdomyolysis (HP:0003201)1.66329813
117Gait imbalance (HP:0002141)1.63214700
118Pancytopenia (HP:0001876)1.61401378
119Multiple enchondromatosis (HP:0005701)1.60602383
120Patent foramen ovale (HP:0001655)1.59712154
121Pallor (HP:0000980)1.59489242
122Testicular atrophy (HP:0000029)1.59378776
123Conjunctival hamartoma (HP:0100780)1.57552804
124Oral leukoplakia (HP:0002745)1.57545937
125Hypothermia (HP:0002045)1.57149992
126Tinnitus (HP:0000360)1.56942668
127Abnormal hair whorl (HP:0010721)1.56933273
128Muscle fiber atrophy (HP:0100295)1.56818744
129Hypoplastic left heart (HP:0004383)1.56743794
130Hypokinesia (HP:0002375)1.56589822
131Myokymia (HP:0002411)1.55974306
132Abnormality of placental membranes (HP:0011409)1.51085875
133Amniotic constriction ring (HP:0009775)1.51085875
134Abnormal urine phosphate concentration (HP:0012599)1.50876807
135Delusions (HP:0000746)1.50408697

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.18993609
2NME24.24792006
3BUB13.95968927
4STK163.31580621
5MAP3K123.15346527
6NME13.09352498
7TSSK62.61009858
8EIF2AK32.50200781
9MYLK2.49523607
10EIF2AK12.30238965
11BCKDK2.21375477
12WEE12.19484663
13PIM22.07048537
14ARAF2.06090448
15SRPK11.91060140
16CASK1.89018545
17TTK1.86809188
18PLK41.85638230
19CCNB11.83526504
20VRK11.75654959
21MAP3K111.74447254
22PINK11.65305976
23AKT31.64658202
24TAF11.63974171
25TRIM281.59888971
26NEK11.53334706
27PDK41.47164628
28PDK31.47164628
29DAPK11.47115385
30BRAF1.45300387
31GRK51.40852413
32OBSCN1.35358237
33PBK1.34992612
34MST41.34553460
35ZAK1.30995782
36IRAK31.30310508
37MUSK1.28881311
38TLK11.27251045
39GRK71.20215449
40MAP2K71.17179694
41CSNK1G31.12941882
42PDK21.10311821
43PLK21.09696780
44MAP4K21.08455056
45TESK21.00734256
46AURKA0.99828910
47STK40.98615503
48ABL20.98187594
49CSNK1G10.95459366
50KDR0.92991328
51ATR0.90837502
52MAP2K60.90141277
53TESK10.89110361
54LIMK10.88451443
55PLK30.85748576
56DAPK30.85024587
57PLK10.84154067
58BMPR20.83836076
59SIK30.83092429
60CSNK1A1L0.82137574
61BRSK10.81836569
62PAK40.81337373
63CSNK1G20.80106263
64DYRK20.76462064
65MKNK20.74160521
66MAPKAPK30.73569855
67CSNK2A10.73241812
68ADRBK20.70680610
69RPS6KA60.68924545
70RPS6KL10.68361383
71RPS6KC10.68361383
72ILK0.66739404
73CDK190.65192154
74CSNK2A20.64139410
75TXK0.63387104
76CDK70.63058645
77BMPR1B0.62601378
78LMTK20.61858172
79CAMK2D0.60574782
80STK100.60223545
81CLK10.57896621
82BRSK20.54858264
83PRKCI0.54044989
84LRRK20.53040423
85PRKCG0.52532397
86EIF2AK20.51589098
87MAP3K80.51507316
88MKNK10.50972429
89EPHA20.50309117
90YES10.49376525
91PRPF4B0.48614354
92PHKG20.48344789
93PHKG10.48344789
94FRK0.48252718
95CHEK10.46737325
96GRK10.46683991
97AURKB0.46407005
98CDK80.46275024
99STK38L0.45775790
100TIE10.44931106
101ATM0.44779881
102TAOK20.44732479
103NEK90.43631611
104MST1R0.43595109
105CAMK2G0.42068218
106WNK40.40921043
107SYK0.40751523
108AKT20.40719384
109CDC70.38394768
110NUAK10.37559304
111PAK10.37431860
112PRKCD0.36282050
113PNCK0.36270901
114CAMK2B0.36099125
115IRAK40.36061041
116TEC0.35790508
117PASK0.35678100
118RPS6KA50.35440379
119DAPK20.35137303
120DYRK30.35064256
121PRKCE0.34654782
122MAPK130.34461923
123ALK0.34378246
124ERBB40.34190008
125BCR0.33694952
126MAPKAPK50.33512840
127PIK3CG0.33281954
128PRKACA0.32535869
129STK30.31705227
130OXSR10.30351158
131STK390.30303877
132ERBB30.29716668
133CAMK2A0.28458454
134CSNK1A10.28106929
135WNK30.27612949
136TNIK0.27422339
137CHEK20.26961919
138INSRR0.25945356
139CDK10.21141944

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.29127637
2Proteasome_Homo sapiens_hsa030504.95123077
3Parkinsons disease_Homo sapiens_hsa050124.57721443
4* Ribosome_Homo sapiens_hsa030103.66692773
5Huntingtons disease_Homo sapiens_hsa050163.29790742
6RNA polymerase_Homo sapiens_hsa030203.22771108
7Alzheimers disease_Homo sapiens_hsa050103.17952420
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.97136705
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.80433989
10Mismatch repair_Homo sapiens_hsa034302.25811229
11DNA replication_Homo sapiens_hsa030302.21601538
12Pyrimidine metabolism_Homo sapiens_hsa002402.08119625
13Protein export_Homo sapiens_hsa030602.03253436
14Cardiac muscle contraction_Homo sapiens_hsa042601.99213785
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.93264550
16Collecting duct acid secretion_Homo sapiens_hsa049661.84218574
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.82940085
18Nucleotide excision repair_Homo sapiens_hsa034201.51739971
19Spliceosome_Homo sapiens_hsa030401.47177894
20Homologous recombination_Homo sapiens_hsa034401.43869794
21Base excision repair_Homo sapiens_hsa034101.41856975
22Pyruvate metabolism_Homo sapiens_hsa006201.31147027
23Carbon metabolism_Homo sapiens_hsa012001.30816731
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.28932151
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.27892318
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27158454
27RNA transport_Homo sapiens_hsa030131.20243152
28Sulfur relay system_Homo sapiens_hsa041221.17503748
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.14995362
30Purine metabolism_Homo sapiens_hsa002301.14328707
31Vibrio cholerae infection_Homo sapiens_hsa051101.12460010
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.10663929
33Fatty acid elongation_Homo sapiens_hsa000621.08288933
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.06775646
35Propanoate metabolism_Homo sapiens_hsa006401.06227068
36Fructose and mannose metabolism_Homo sapiens_hsa000511.03132152
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.02824946
38Basal transcription factors_Homo sapiens_hsa030220.95790397
39Metabolic pathways_Homo sapiens_hsa011000.92068006
40Steroid biosynthesis_Homo sapiens_hsa001000.89424387
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88430718
42Folate biosynthesis_Homo sapiens_hsa007900.86733957
43Selenocompound metabolism_Homo sapiens_hsa004500.85466334
44Biosynthesis of amino acids_Homo sapiens_hsa012300.84498398
45SNARE interactions in vesicular transport_Homo sapiens_hsa041300.82488334
46Maturity onset diabetes of the young_Homo sapiens_hsa049500.81484543
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79977879
48Synaptic vesicle cycle_Homo sapiens_hsa047210.79947613
49RNA degradation_Homo sapiens_hsa030180.78823220
50Vitamin B6 metabolism_Homo sapiens_hsa007500.78820450
51Rheumatoid arthritis_Homo sapiens_hsa053230.77824145
52Glutathione metabolism_Homo sapiens_hsa004800.77537475
53One carbon pool by folate_Homo sapiens_hsa006700.75598756
54Sulfur metabolism_Homo sapiens_hsa009200.75583614
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71269954
56Regulation of autophagy_Homo sapiens_hsa041400.68495042
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67169320
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.65723624
59Pentose phosphate pathway_Homo sapiens_hsa000300.64970127
60Peroxisome_Homo sapiens_hsa041460.64582518
61Fanconi anemia pathway_Homo sapiens_hsa034600.61810615
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61444739
63Non-homologous end-joining_Homo sapiens_hsa034500.61192137
64Epstein-Barr virus infection_Homo sapiens_hsa051690.56568581
65Arachidonic acid metabolism_Homo sapiens_hsa005900.56098664
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55381602
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.54613358
68Galactose metabolism_Homo sapiens_hsa000520.53131228
69Phenylalanine metabolism_Homo sapiens_hsa003600.52567901
70Arginine biosynthesis_Homo sapiens_hsa002200.51926776
71Tryptophan metabolism_Homo sapiens_hsa003800.50838311
72Phagosome_Homo sapiens_hsa041450.50759068
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48529639
74Tyrosine metabolism_Homo sapiens_hsa003500.44075611
75Arginine and proline metabolism_Homo sapiens_hsa003300.43629697
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.43366906
77Cell cycle_Homo sapiens_hsa041100.42479615
78Systemic lupus erythematosus_Homo sapiens_hsa053220.40363119
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40236161
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37935679
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34361981
82Legionellosis_Homo sapiens_hsa051340.33828359
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.32897970
84mRNA surveillance pathway_Homo sapiens_hsa030150.31227406
85Butanoate metabolism_Homo sapiens_hsa006500.29791598
86Chemical carcinogenesis_Homo sapiens_hsa052040.28320035
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28236970
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.27673124
89Fat digestion and absorption_Homo sapiens_hsa049750.26542084
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.25377655
91Graft-versus-host disease_Homo sapiens_hsa053320.25372515
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25106594
93Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.24853712
94Asthma_Homo sapiens_hsa053100.23749139
95Type I diabetes mellitus_Homo sapiens_hsa049400.23595751
96Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.23202351
97Other glycan degradation_Homo sapiens_hsa005110.22941396
98Allograft rejection_Homo sapiens_hsa053300.22657497
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.22376669
100Retinol metabolism_Homo sapiens_hsa008300.21376160
101Caffeine metabolism_Homo sapiens_hsa002320.21061234
102Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.20385453
103Fatty acid degradation_Homo sapiens_hsa000710.19073132
104Fatty acid metabolism_Homo sapiens_hsa012120.18982070
105Linoleic acid metabolism_Homo sapiens_hsa005910.17535501
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.16585914
107Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.16353061
108Phototransduction_Homo sapiens_hsa047440.15206706
109N-Glycan biosynthesis_Homo sapiens_hsa005100.14794976
110Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.12803819
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.11368975
112beta-Alanine metabolism_Homo sapiens_hsa004100.11277121
113Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.11174211
114Vitamin digestion and absorption_Homo sapiens_hsa049770.10122591
115Cyanoamino acid metabolism_Homo sapiens_hsa004600.09132915
116Lysosome_Homo sapiens_hsa041420.07966952
117Antigen processing and presentation_Homo sapiens_hsa046120.07561930
118Pentose and glucuronate interconversions_Homo sapiens_hsa000400.06841018
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.05593270
120p53 signaling pathway_Homo sapiens_hsa041150.05190903
121Intestinal immune network for IgA production_Homo sapiens_hsa046720.04991274
122Nicotine addiction_Homo sapiens_hsa050330.04425533
123Oocyte meiosis_Homo sapiens_hsa041140.03170242

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