MRPS18AP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.71778262
2negative regulation of cell killing (GO:0031342)5.17309557
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.17309557
4regulation of regulatory T cell differentiation (GO:0045589)5.09625512
5regulation of gamma-delta T cell activation (GO:0046643)5.04642441
6tolerance induction (GO:0002507)4.87268887
7regulation of gamma-delta T cell differentiation (GO:0045586)4.74575816
8regulation of B cell receptor signaling pathway (GO:0050855)4.50443573
9positive regulation of interleukin-17 production (GO:0032740)4.27975581
10positive regulation of B cell differentiation (GO:0045579)4.24537620
11detection of bacterium (GO:0016045)4.18573065
12detection of other organism (GO:0098543)4.15024941
13histone H3-K36 demethylation (GO:0070544)4.13124669
14regulation of B cell differentiation (GO:0045577)4.09966136
15B cell receptor signaling pathway (GO:0050853)4.05872741
16positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.02756688
17cellular extravasation (GO:0045123)4.01848938
18positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.99067650
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.94724847
20activated T cell proliferation (GO:0050798)3.86278726
21negative thymic T cell selection (GO:0045060)3.85428713
22antigen processing and presentation of endogenous antigen (GO:0019883)3.83545486
23antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.78929319
24negative regulation of T cell mediated immunity (GO:0002710)3.77004228
25respiratory burst (GO:0045730)3.75422025
26positive regulation of isotype switching (GO:0045830)3.72230303
27leukocyte aggregation (GO:0070486)3.71390333
28antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.65201874
29regulation of memory T cell differentiation (GO:0043380)3.63609641
30negative T cell selection (GO:0043383)3.62347288
31negative regulation of lymphocyte mediated immunity (GO:0002707)3.61773529
32response to peptidoglycan (GO:0032494)3.58547378
33positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.58222711
34response to muramyl dipeptide (GO:0032495)3.57744304
35modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.55973510
36positive regulation by organism of defense response of other organism involved in symbiotic interact3.55973510
37modulation by symbiont of host immune response (GO:0052553)3.55973510
38positive regulation by symbiont of host defense response (GO:0052509)3.55973510
39modulation by symbiont of host defense response (GO:0052031)3.55973510
40modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.55973510
41regulation of isotype switching to IgG isotypes (GO:0048302)3.53204006
42negative regulation of interleukin-12 production (GO:0032695)3.46802047
43interferon-gamma production (GO:0032609)3.44920013
44Peyers patch development (GO:0048541)3.44614819
45mucosal-associated lymphoid tissue development (GO:0048537)3.44614819
46T cell selection (GO:0045058)3.33655831
47natural killer cell differentiation (GO:0001779)3.32189836
48negative regulation of erythrocyte differentiation (GO:0045647)3.30159460
49regulation of interleukin-2 biosynthetic process (GO:0045076)3.28657611
50positive thymic T cell selection (GO:0045059)3.26294555
51response to interleukin-15 (GO:0070672)3.25174022
52T cell migration (GO:0072678)3.24453715
53regulation of interleukin-17 production (GO:0032660)3.20642962
54negative regulation of B cell apoptotic process (GO:0002903)3.17951066
55thymic T cell selection (GO:0045061)3.16637116
56regulation of isotype switching (GO:0045191)3.13459385
57production of molecular mediator involved in inflammatory response (GO:0002532)3.12860520
58positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.06244253
59macrophage activation involved in immune response (GO:0002281)3.03050829
60negative regulation of interleukin-6 production (GO:0032715)3.00737592
61antigen processing and presentation via MHC class Ib (GO:0002475)3.00641684
62positive regulation of DNA recombination (GO:0045911)3.00575243
63positive T cell selection (GO:0043368)2.97391906
64neutrophil activation involved in immune response (GO:0002283)2.97020449
65T cell homeostasis (GO:0043029)2.96990786
66cellular response to interleukin-15 (GO:0071350)2.94605563
67positive regulation of granulocyte differentiation (GO:0030854)2.94375795
68regulation of natural killer cell mediated immunity (GO:0002715)2.94150301
69regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.94150301
70positive regulation of mast cell activation (GO:0033005)2.93526713
71regulation of T cell tolerance induction (GO:0002664)2.93427878
72histone H3-K4 trimethylation (GO:0080182)2.90939937
73regulation of B cell apoptotic process (GO:0002902)2.89783767
74neutrophil activation (GO:0042119)2.89319431
75defense response to protozoan (GO:0042832)2.88369767
76negative regulation of leukocyte mediated immunity (GO:0002704)2.86732334
77negative regulation of interleukin-1 beta production (GO:0032691)2.86136491
78positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.84251523
79detection of external biotic stimulus (GO:0098581)2.84179847
80detection of biotic stimulus (GO:0009595)2.81769013
81natural killer cell activation (GO:0030101)2.81503338
82regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.79812298
83positive regulation of B cell mediated immunity (GO:0002714)2.78579358
84positive regulation of immunoglobulin mediated immune response (GO:0002891)2.78579358
85regulation of tolerance induction (GO:0002643)2.75723561
86regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.75251971
87negative regulation of translation, ncRNA-mediated (GO:0040033)2.71777121
88regulation of translation, ncRNA-mediated (GO:0045974)2.71777121
89negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.71777121
90determination of adult lifespan (GO:0008340)2.71247956
91positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.71003729
92regulation of T cell mediated cytotoxicity (GO:0001914)2.69618578
93response to protozoan (GO:0001562)2.68601262
94regulation of B cell mediated immunity (GO:0002712)2.68510680
95regulation of alpha-beta T cell proliferation (GO:0046640)2.68083025
96negative regulation of adaptive immune response (GO:0002820)2.66235320
97germinal center formation (GO:0002467)2.65670666
98regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.65494285
99positive regulation of B cell activation (GO:0050871)2.64931588
100T cell proliferation (GO:0042098)2.64879058

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.46516473
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.21100259
3MYC_22102868_ChIP-Seq_BL_Human3.99386358
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.45959785
5VDR_21846776_ChIP-Seq_THP-1_Human3.21495915
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.14479086
7RUNX_20019798_ChIP-Seq_JUKART_Human2.92670486
8MYB_26560356_Chip-Seq_TH2_Human2.80490316
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.74567553
10MAF_26560356_Chip-Seq_TH1_Human2.73167191
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.69932437
12VDR_24763502_ChIP-Seq_THP-1_Human2.68938482
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.67988972
14E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.63442536
15SPI1_23547873_ChIP-Seq_NB4_Human2.55987245
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.55191898
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.54527004
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.53558495
19GATA1_22025678_ChIP-Seq_K562_Human2.52803908
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.42062645
21IRF8_27001747_Chip-Seq_BMDM_Mouse2.41864567
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.39205635
23MYB_26560356_Chip-Seq_TH1_Human2.34887528
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.26886796
25UTX_26944678_Chip-Seq_JUKART_Human2.25544836
26FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.20128032
27SPI1_23127762_ChIP-Seq_K562_Human2.17657124
28MAF_26560356_Chip-Seq_TH2_Human2.16843543
29E2F7_22180533_ChIP-Seq_HELA_Human2.04179822
30STAT4_19710469_ChIP-ChIP_TH1__Mouse1.99252908
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.98380750
32GATA3_27048872_Chip-Seq_THYMUS_Human1.97184127
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.96767593
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.87751154
35KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.86666609
36MYB_21317192_ChIP-Seq_ERMYB_Mouse1.77506474
37TCF7_22412390_ChIP-Seq_EML_Mouse1.74704858
38FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.72583232
39RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.71319030
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.68846457
41SCL_19346495_ChIP-Seq_HPC-7_Human1.68347198
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.68192374
43IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.62632738
44KDM2B_26808549_Chip-Seq_DND41_Human1.57042740
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.52190439
46ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.51820904
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.45656088
48GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.44871546
49VDR_24787735_ChIP-Seq_THP-1_Human1.44321753
50KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.41742533
51CIITA_25753668_ChIP-Seq_RAJI_Human1.40328067
52HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.40069225
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38642423
54VDR_23849224_ChIP-Seq_CD4+_Human1.34276719
55IRF1_19129219_ChIP-ChIP_H3396_Human1.30446715
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.27121823
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25288563
58THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21261814
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.19403053
60GATA3_26560356_Chip-Seq_TH2_Human1.19002616
61PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18965700
62PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17549511
63STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14593131
64VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.12210881
65CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11816503
66ELF1_20517297_ChIP-Seq_JURKAT_Human1.10177683
67NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.09968718
68TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09706691
69NCOR1_26117541_ChIP-Seq_K562_Human1.09510578
70KDM2B_26808549_Chip-Seq_JURKAT_Human1.08330184
71CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06388065
72FOXP3_21729870_ChIP-Seq_TREG_Human1.05225432
73TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03184700
74GATA2_22383799_ChIP-Seq_G1ME_Mouse1.03005844
75FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02514851
76SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01951288
77RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01801180
78PU_27001747_Chip-Seq_BMDM_Mouse1.01201431
79PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00432375
80EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.00033898
81CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99911938
82RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.99896127
83E2F4_17652178_ChIP-ChIP_JURKAT_Human0.98428988
84GATA1_19941827_ChIP-Seq_MEL_Mouse0.95533735
85GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93192604
86GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91786298
87RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.91752267
88PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89035889
89BCL6_27268052_Chip-Seq_Bcells_Human0.88806579
90CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88403430
91MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.88086295
92PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87397175
93BCOR_27268052_Chip-Seq_Bcells_Human0.87149147
94BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.86960568
95GATA3_26560356_Chip-Seq_TH1_Human0.86118907
96SMRT_27268052_Chip-Seq_Bcells_Human0.85379709
97BP1_19119308_ChIP-ChIP_Hs578T_Human0.85289260
98CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.83761957
99GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.82699486
100KDM5A_27292631_Chip-Seq_BREAST_Human0.82010658

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.87028177
2MP0005671_abnormal_response_to3.39079075
3MP0003300_gastrointestinal_ulcer3.32749144
4MP0001853_heart_inflammation3.20997952
5MP0003436_decreased_susceptibility_to3.10314782
6MP0001800_abnormal_humoral_immune2.91738693
7MP0003763_abnormal_thymus_physiology2.70567388
8MP0001790_abnormal_immune_system2.58647982
9MP0005387_immune_system_phenotype2.58647982
10MP0005000_abnormal_immune_tolerance2.56588203
11MP0002822_catalepsy2.56472082
12MP0002419_abnormal_innate_immunity2.46281984
13MP0000685_abnormal_immune_system2.45576220
14MP0002452_abnormal_antigen_presenting2.42506150
15MP0002420_abnormal_adaptive_immunity2.40391357
16MP0002723_abnormal_immune_serum2.39638215
17MP0001819_abnormal_immune_cell2.37461491
18MP0003303_peritoneal_inflammation2.32780750
19MP0002405_respiratory_system_inflammati2.30196430
20MP0003724_increased_susceptibility_to2.27061987
21MP0001873_stomach_inflammation2.25429312
22MP0005025_abnormal_response_to2.22269927
23MP0003172_abnormal_lysosome_physiology2.15955098
24MP0002396_abnormal_hematopoietic_system2.15581256
25MP0002398_abnormal_bone_marrow2.11593485
26MP0000703_abnormal_thymus_morphology1.96810219
27MP0000465_gastrointestinal_hemorrhage1.94127210
28MP0000716_abnormal_immune_system1.93433322
29MP0000689_abnormal_spleen_morphology1.93057776
30MP0009785_altered_susceptibility_to1.84539378
31MP0002148_abnormal_hypersensitivity_rea1.83121992
32MP0002722_abnormal_immune_system1.81528829
33MP0002009_preneoplasia1.74224055
34MP0008961_abnormal_basal_metabolism1.71094218
35MP0008057_abnormal_DNA_replication1.65871627
36MP0009333_abnormal_splenocyte_physiolog1.61620846
37MP0002429_abnormal_blood_cell1.55411878
38MP0001845_abnormal_inflammatory_respons1.53181877
39MP0009278_abnormal_bone_marrow1.50973853
40MP0005645_abnormal_hypothalamus_physiol1.48057514
41MP0001986_abnormal_taste_sensitivity1.46885233
42MP0005310_abnormal_salivary_gland1.46586186
43MP0005058_abnormal_lysosome_morphology1.45028383
44MP0002653_abnormal_ependyma_morphology1.42291463
45MP0010155_abnormal_intestine_physiology1.35486456
46MP0000569_abnormal_digit_pigmentation1.34778014
47MP0002254_reproductive_system_inflammat1.30334675
48MP0004808_abnormal_hematopoietic_stem1.27184532
49MP0004185_abnormal_adipocyte_glucose1.24738223
50MP0002693_abnormal_pancreas_physiology1.23368087
51MP0006082_CNS_inflammation1.20413867
52MP0002166_altered_tumor_susceptibility1.16476117
53MP0003787_abnormal_imprinting1.15559572
54MP0001851_eye_inflammation1.12584174
55MP0004133_heterotaxia1.10704152
56MP0000604_amyloidosis1.09652301
57MP0004947_skin_inflammation1.09021432
58MP0003959_abnormal_lean_body1.06304163
59MP0000013_abnormal_adipose_tissue1.03857789
60MP0005451_abnormal_body_composition1.03725128
61MP0002277_abnormal_respiratory_mucosa1.01585513
62MP0004883_abnormal_blood_vessel1.01497055
63MP0006035_abnormal_mitochondrial_morpho1.00996064
64MP0001533_abnormal_skeleton_physiology0.99707328
65MP0002998_abnormal_bone_remodeling0.96327775
66MP0008260_abnormal_autophagy0.96021873
67MP0003283_abnormal_digestive_organ0.94525683
68MP0008469_abnormal_protein_level0.91848762
69MP0004381_abnormal_hair_follicle0.89690439
70MP0005464_abnormal_platelet_physiology0.88846097
71MP0003786_premature_aging0.84364552
72MP0002019_abnormal_tumor_incidence0.83876934
73MP0004742_abnormal_vestibular_system0.83370975
74MP0002933_joint_inflammation0.79976110
75MP0004885_abnormal_endolymph0.76672464
76MP0008995_early_reproductive_senescence0.74556183
77MP0003866_abnormal_defecation0.73416467
78MP0009115_abnormal_fat_cell0.71466588
79MP0009840_abnormal_foam_cell0.70989998
80MP0000490_abnormal_crypts_of0.69652184
81MP0005666_abnormal_adipose_tissue0.69281557
82MP0002006_tumorigenesis0.68765918
83MP0005397_hematopoietic_system_phenotyp0.67882521
84MP0001545_abnormal_hematopoietic_system0.67882521
85MP0002132_abnormal_respiratory_system0.67066085
86MP0009764_decreased_sensitivity_to0.66711296
87MP0003191_abnormal_cellular_cholesterol0.65639019
88MP0000858_altered_metastatic_potential0.64470090
89MP0003077_abnormal_cell_cycle0.63162205
90MP0005375_adipose_tissue_phenotype0.63156791
91MP0003091_abnormal_cell_migration0.63140191
92MP0001663_abnormal_digestive_system0.62835688
93MP0000427_abnormal_hair_cycle0.62699656
94MP0005083_abnormal_biliary_tract0.58040392
95MP0003638_abnormal_response/metabolism_0.57456416
96MP0001485_abnormal_pinna_reflex0.56337676
97MP0008058_abnormal_DNA_repair0.54581927
98MP0000609_abnormal_liver_physiology0.52851654
99MP0003252_abnormal_bile_duct0.52779693
100MP0000383_abnormal_hair_follicle0.49570628

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)4.68499156
2Eczematoid dermatitis (HP:0000976)4.42910980
3Recurrent cutaneous fungal infections (HP:0011370)4.26140229
4Chronic mucocutaneous candidiasis (HP:0002728)4.26140229
5Elevated erythrocyte sedimentation rate (HP:0003565)4.24910237
6Recurrent bacterial skin infections (HP:0005406)4.05008397
7Recurrent fungal infections (HP:0002841)4.03451852
8Panhypogammaglobulinemia (HP:0003139)3.91395894
9Abnormality of macrophages (HP:0004311)3.89499146
10Recurrent abscess formation (HP:0002722)3.89085420
11Retrobulbar optic neuritis (HP:0100654)3.80476026
12Optic neuritis (HP:0100653)3.80476026
13Myositis (HP:0100614)3.70649781
14Abnormal delayed hypersensitivity skin test (HP:0002963)3.59004808
15Gastrointestinal stroma tumor (HP:0100723)3.57576840
16Colon cancer (HP:0003003)3.57213747
17Meningitis (HP:0001287)3.42454552
18Encephalitis (HP:0002383)3.38785193
19Orchitis (HP:0100796)3.32273006
20Lymphopenia (HP:0001888)3.29799729
21Recurrent viral infections (HP:0004429)3.25477726
22Colitis (HP:0002583)3.11159444
23Recurrent skin infections (HP:0001581)3.05482565
24Vasculitis (HP:0002633)3.05173709
25Recurrent gram-negative bacterial infections (HP:0005420)2.99789038
26Agammaglobulinemia (HP:0004432)2.98136881
27Mediastinal lymphadenopathy (HP:0100721)2.96417171
28Pustule (HP:0200039)2.89842471
29Abnormality of cells of the lymphoid lineage (HP:0012140)2.89528798
30Inflammation of the large intestine (HP:0002037)2.89082754
31T lymphocytopenia (HP:0005403)2.87373334
32Keratoconjunctivitis (HP:0001096)2.84056615
33Gastrointestinal inflammation (HP:0004386)2.81614620
34Abnormal number of erythroid precursors (HP:0012131)2.80217144
35Obstructive lung disease (HP:0006536)2.71462918
36Chronic obstructive pulmonary disease (HP:0006510)2.71462918
37Keratoconjunctivitis sicca (HP:0001097)2.71075484
38IgM deficiency (HP:0002850)2.65731998
39Abnormality of cells of the erythroid lineage (HP:0012130)2.65236555
40Increased IgE level (HP:0003212)2.62028000
41Abnormality of T cells (HP:0002843)2.59744844
42Recurrent sinusitis (HP:0011108)2.58247121
43Basal cell carcinoma (HP:0002671)2.53084377
44Abnormality of T cell number (HP:0011839)2.51326257
45Viral hepatitis (HP:0006562)2.42731354
46Vacuolated lymphocytes (HP:0001922)2.34816021
47Abnormality of the fingertips (HP:0001211)2.29936717
48Leukopenia (HP:0001882)2.29600179
49Recurrent bronchitis (HP:0002837)2.28988891
50Gastrointestinal infarctions (HP:0005244)2.28768599
51Abnormality of T cell physiology (HP:0011840)2.27677381
52Abnormal hair laboratory examination (HP:0003328)2.26965280
53Severe combined immunodeficiency (HP:0004430)2.21893474
54Hypoplasia of the thymus (HP:0000778)2.20657668
55Pallor (HP:0000980)2.20365820
56Reticulocytopenia (HP:0001896)2.18535128
57Supernumerary bones of the axial skeleton (HP:0009144)2.17765812
58Leukocytosis (HP:0001974)2.15417623
59Abnormality of pyrimidine metabolism (HP:0004353)2.13293617
60IgG deficiency (HP:0004315)2.11232707
61Abnormality of cochlea (HP:0000375)2.09758559
62Thrombocytosis (HP:0001894)2.08755031
63Verrucae (HP:0200043)2.08265765
64Papilloma (HP:0012740)2.08265765
65Hemoptysis (HP:0002105)2.06564842
66Lymphoma (HP:0002665)2.04117122
67Cellulitis (HP:0100658)2.02813547
68Spontaneous hematomas (HP:0007420)2.01503187
69Pulmonary infiltrates (HP:0002113)1.99174602
70Osteomyelitis (HP:0002754)1.98489217
71Combined immunodeficiency (HP:0005387)1.97104156
72Prolonged bleeding time (HP:0003010)1.95728557
73Urticaria (HP:0001025)1.95278496
74Restrictive lung disease (HP:0002091)1.92665747
75Stomach cancer (HP:0012126)1.91789689
76Abnormality of the pleura (HP:0002103)1.91610309
77Anorexia (HP:0002039)1.89958740
78Abnormality of eosinophils (HP:0001879)1.88436303
79Hematochezia (HP:0002573)1.87717803
80Chest pain (HP:0100749)1.85747160
81Granulocytopenia (HP:0001913)1.85633801
82Supernumerary ribs (HP:0005815)1.85484437
83Global brain atrophy (HP:0002283)1.84647552
84Oligodactyly (hands) (HP:0001180)1.84202608
85Birth length less than 3rd percentile (HP:0003561)1.81198611
8611 pairs of ribs (HP:0000878)1.80836767
87Keratitis (HP:0000491)1.80541865
88Increased cerebral lipofuscin (HP:0011813)1.78427122
89Gingivitis (HP:0000230)1.78268348
90Respiratory difficulties (HP:0002880)1.77417054
91Polyneuropathy (HP:0001271)1.75107125
92Abnormality of homocysteine metabolism (HP:0010919)1.74914375
93Homocystinuria (HP:0002156)1.74914375
94Hepatosplenomegaly (HP:0001433)1.74223884
95Arterial thrombosis (HP:0004420)1.74067160
96Amaurosis fugax (HP:0100576)1.73875285
97B lymphocytopenia (HP:0010976)1.72331848
98Villous atrophy (HP:0011473)1.68726904
99Abnormality of small intestinal villus morphology (HP:0011472)1.68726904
100Long eyelashes (HP:0000527)1.68252113

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.23501374
2CAMK1D3.90791401
3RIPK43.69083393
4CAMKK23.12732735
5PASK2.95619363
6BLK2.64237030
7TYK22.57945308
8CAMK1G2.33634588
9BTK2.12177929
10TXK2.11585509
11PRPF4B2.08372378
12SIK32.03847479
13CSK1.95208379
14CAMKK11.86090250
15CDK121.84549160
16MAP3K141.68798311
17ITK1.66178113
18IRAK41.62486600
19PRKD21.59795882
20TEC1.57578198
21SYK1.56131186
22MAP2K31.43629927
23FES1.41021683
24MAP3K101.40703533
25JAK31.38646165
26STK101.35924151
27ZAP701.33827897
28SMG11.33046965
29IKBKE1.32313149
30GRK61.28945674
31NEK11.19008278
32MAP3K41.18812485
33HCK1.16962659
34MAPK151.16564161
35LYN1.15521617
36JAK11.14107390
37JAK21.10233559
38MARK31.10030511
39LCK1.08236801
40NLK1.05402354
41PTK61.03620360
42TSSK61.02053390
43INSRR0.96096333
44SIK20.95234856
45CAMK40.93516261
46IKBKB0.92846285
47KIT0.90810035
48CSF1R0.87704105
49PRKCH0.86998670
50TNK20.84695555
51MARK20.82605209
52MAP3K130.81527436
53MAP2K60.80747795
54FGR0.80528842
55TAOK10.78483894
56ERN10.78067885
57LRRK20.77005337
58CDK40.72865350
59MST40.72736721
60MKNK10.71325032
61PDK10.69142885
62TAOK30.68502486
63SGK20.68132655
64FGFR40.66812858
65BMPR20.66620420
66PRKCQ0.65794372
67TRIB30.65023996
68TBK10.61096242
69YES10.61013775
70FGFR30.56389732
71PNCK0.56007810
72UHMK10.55665367
73TLK10.53745129
74MAP3K70.53114845
75TGFBR10.50972216
76PIM10.50878765
77CAMK10.50440681
78MKNK20.50031795
79KSR10.49994714
80PTK2B0.49971987
81ICK0.44186181
82MAPK120.43012257
83DAPK20.42817440
84WNK10.41848918
85CDK60.40980751
86WEE10.40934697
87MAPK70.40857514
88FYN0.40798614
89CDC42BPA0.40175889
90PKN20.39494165
91PDPK10.35670532
92MATK0.35299156
93TGFBR20.34905781
94SIK10.34645902
95RPS6KA40.32496740
96SGK30.32103132
97STK240.31313483
98MAPK110.30522090
99CHUK0.30122428
100ALK0.29058307

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.54466219
2Type I diabetes mellitus_Homo sapiens_hsa049402.95455975
3Allograft rejection_Homo sapiens_hsa053302.95346956
4Graft-versus-host disease_Homo sapiens_hsa053322.82300696
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.69091735
6Autoimmune thyroid disease_Homo sapiens_hsa053202.65346893
7B cell receptor signaling pathway_Homo sapiens_hsa046622.43175864
8Leishmaniasis_Homo sapiens_hsa051402.40864024
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.39231617
10Osteoclast differentiation_Homo sapiens_hsa043802.25160602
11T cell receptor signaling pathway_Homo sapiens_hsa046602.14294931
12Asthma_Homo sapiens_hsa053102.06049165
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.94863292
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.93413501
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.93226288
16Hematopoietic cell lineage_Homo sapiens_hsa046401.91564913
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.85929547
18Measles_Homo sapiens_hsa051621.82166320
19Acute myeloid leukemia_Homo sapiens_hsa052211.71824954
20Staphylococcus aureus infection_Homo sapiens_hsa051501.66382174
21Antigen processing and presentation_Homo sapiens_hsa046121.64473433
22Jak-STAT signaling pathway_Homo sapiens_hsa046301.62581666
23Non-small cell lung cancer_Homo sapiens_hsa052231.57794318
24Tuberculosis_Homo sapiens_hsa051521.53096324
25Legionellosis_Homo sapiens_hsa051341.50584068
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.48616040
27Chemokine signaling pathway_Homo sapiens_hsa040621.46688674
28Other glycan degradation_Homo sapiens_hsa005111.44064148
29Herpes simplex infection_Homo sapiens_hsa051681.35621765
30Toxoplasmosis_Homo sapiens_hsa051451.33290992
31Notch signaling pathway_Homo sapiens_hsa043301.31452832
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.27544742
33Ribosome_Homo sapiens_hsa030101.25743705
34TNF signaling pathway_Homo sapiens_hsa046681.24185978
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.22131553
36Colorectal cancer_Homo sapiens_hsa052101.16990607
37Influenza A_Homo sapiens_hsa051641.16322484
38Malaria_Homo sapiens_hsa051441.08074916
39Transcriptional misregulation in cancer_Homo sapiens_hsa052021.05955080
40Epstein-Barr virus infection_Homo sapiens_hsa051691.03631435
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.01107818
42Pertussis_Homo sapiens_hsa051330.99204360
43Hepatitis B_Homo sapiens_hsa051610.98265405
44Leukocyte transendothelial migration_Homo sapiens_hsa046700.97528303
45HTLV-I infection_Homo sapiens_hsa051660.84047322
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83357770
47Prostate cancer_Homo sapiens_hsa052150.83246248
48Base excision repair_Homo sapiens_hsa034100.82062788
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81442274
50Viral myocarditis_Homo sapiens_hsa054160.79092219
51Steroid biosynthesis_Homo sapiens_hsa001000.78533675
52Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.75941075
53Platelet activation_Homo sapiens_hsa046110.74284370
54Pancreatic cancer_Homo sapiens_hsa052120.73535481
55Chronic myeloid leukemia_Homo sapiens_hsa052200.72139213
56Viral carcinogenesis_Homo sapiens_hsa052030.71913297
57Dorso-ventral axis formation_Homo sapiens_hsa043200.71798808
58Choline metabolism in cancer_Homo sapiens_hsa052310.69098909
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69045843
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68374619
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66829916
62Apoptosis_Homo sapiens_hsa042100.66665923
63Spliceosome_Homo sapiens_hsa030400.66240272
64Rheumatoid arthritis_Homo sapiens_hsa053230.65911446
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65586143
66Renal cell carcinoma_Homo sapiens_hsa052110.64717892
67FoxO signaling pathway_Homo sapiens_hsa040680.64248397
68African trypanosomiasis_Homo sapiens_hsa051430.63994958
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.63910559
70Thyroid cancer_Homo sapiens_hsa052160.63746048
71Estrogen signaling pathway_Homo sapiens_hsa049150.62190512
72Inositol phosphate metabolism_Homo sapiens_hsa005620.61709198
73VEGF signaling pathway_Homo sapiens_hsa043700.59151436
74Prolactin signaling pathway_Homo sapiens_hsa049170.58990345
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53833919
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53800735
77HIF-1 signaling pathway_Homo sapiens_hsa040660.51669342
78Endometrial cancer_Homo sapiens_hsa052130.51470994
79GnRH signaling pathway_Homo sapiens_hsa049120.50791531
80mRNA surveillance pathway_Homo sapiens_hsa030150.49089682
81Lysosome_Homo sapiens_hsa041420.48733479
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48325687
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47713952
84Fanconi anemia pathway_Homo sapiens_hsa034600.45692608
85Shigellosis_Homo sapiens_hsa051310.44877156
86Hepatitis C_Homo sapiens_hsa051600.43382488
87Type II diabetes mellitus_Homo sapiens_hsa049300.42682444
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.40384127
89MAPK signaling pathway_Homo sapiens_hsa040100.39725265
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36364779
91Insulin resistance_Homo sapiens_hsa049310.35550143
92Salmonella infection_Homo sapiens_hsa051320.33822077
93Regulation of autophagy_Homo sapiens_hsa041400.33797492
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32904437
95DNA replication_Homo sapiens_hsa030300.30722940
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29311151
97Basal transcription factors_Homo sapiens_hsa030220.28106467
98RNA degradation_Homo sapiens_hsa030180.28084206
99mTOR signaling pathway_Homo sapiens_hsa041500.27839112
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.27624273

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