Rank | Gene Set | Z-score |
---|---|---|
1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.48796279 |
2 | chaperone-mediated protein transport (GO:0072321) | 5.25217305 |
3 | ATP synthesis coupled proton transport (GO:0015986) | 5.16927344 |
4 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 5.16927344 |
5 | DNA deamination (GO:0045006) | 4.99927305 |
6 | nucleobase biosynthetic process (GO:0046112) | 4.86702239 |
7 | proteasome assembly (GO:0043248) | 4.84902591 |
8 | purine nucleobase biosynthetic process (GO:0009113) | 4.83075183 |
9 | ribosome assembly (GO:0042255) | 4.65221146 |
10 | formation of translation preinitiation complex (GO:0001731) | 4.61083864 |
11 | maturation of SSU-rRNA (GO:0030490) | 4.42274508 |
12 | respiratory electron transport chain (GO:0022904) | 4.31540889 |
13 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.30153125 |
14 | ribosome biogenesis (GO:0042254) | 4.26769487 |
15 | rRNA modification (GO:0000154) | 4.25914237 |
16 | electron transport chain (GO:0022900) | 4.23127234 |
17 | protein complex biogenesis (GO:0070271) | 4.20122961 |
18 | oxidative phosphorylation (GO:0006119) | 4.16493092 |
19 | DNA replication checkpoint (GO:0000076) | 4.15172217 |
20 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.11319033 |
21 | folic acid metabolic process (GO:0046655) | 4.08996058 |
22 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.06432999 |
23 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.06432999 |
24 | NADH dehydrogenase complex assembly (GO:0010257) | 4.06432999 |
25 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.06350010 |
26 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.03866112 |
27 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.98049077 |
28 | DNA replication initiation (GO:0006270) | 3.97970212 |
29 | DNA strand elongation (GO:0022616) | 3.92656961 |
30 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.91981300 |
31 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.89350090 |
32 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.87616495 |
33 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.87540530 |
34 | termination of RNA polymerase III transcription (GO:0006386) | 3.84071132 |
35 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.84071132 |
36 | ribosomal large subunit biogenesis (GO:0042273) | 3.79247479 |
37 | ribosomal small subunit assembly (GO:0000028) | 3.78393424 |
38 | protein targeting to mitochondrion (GO:0006626) | 3.73649613 |
39 | GDP-mannose metabolic process (GO:0019673) | 3.69696450 |
40 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.66149934 |
41 | negative regulation of ligase activity (GO:0051352) | 3.64556844 |
42 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.64556844 |
43 | pseudouridine synthesis (GO:0001522) | 3.63349154 |
44 | mitotic metaphase plate congression (GO:0007080) | 3.63226725 |
45 | rRNA processing (GO:0006364) | 3.60957271 |
46 | respiratory chain complex IV assembly (GO:0008535) | 3.58541650 |
47 | spliceosomal snRNP assembly (GO:0000387) | 3.55687018 |
48 | IMP biosynthetic process (GO:0006188) | 3.55248644 |
49 | establishment of integrated proviral latency (GO:0075713) | 3.54753604 |
50 | telomere maintenance via recombination (GO:0000722) | 3.54236612 |
51 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.54040426 |
52 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.51676580 |
53 | 7-methylguanosine mRNA capping (GO:0006370) | 3.51621285 |
54 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.51150621 |
55 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.49041334 |
56 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.49041334 |
57 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.48130178 |
58 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.48130178 |
59 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.48130178 |
60 | rRNA metabolic process (GO:0016072) | 3.48080650 |
61 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.46707891 |
62 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.46707891 |
63 | cytochrome complex assembly (GO:0017004) | 3.46536589 |
64 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.46310951 |
65 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.43291237 |
66 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.43291237 |
67 | 7-methylguanosine RNA capping (GO:0009452) | 3.42548636 |
68 | RNA capping (GO:0036260) | 3.42548636 |
69 | establishment of protein localization to mitochondrion (GO:0072655) | 3.41661657 |
70 | termination of RNA polymerase I transcription (GO:0006363) | 3.38456309 |
71 | amino acid salvage (GO:0043102) | 3.37085988 |
72 | L-methionine salvage (GO:0071267) | 3.37085988 |
73 | L-methionine biosynthetic process (GO:0071265) | 3.37085988 |
74 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.37015978 |
75 | regulation of mitochondrial translation (GO:0070129) | 3.36842536 |
76 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.36719752 |
77 | rRNA methylation (GO:0031167) | 3.35286278 |
78 | protein localization to mitochondrion (GO:0070585) | 3.35071562 |
79 | transcription from RNA polymerase I promoter (GO:0006360) | 3.34690114 |
80 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.34252571 |
81 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.33083803 |
82 | positive regulation of ligase activity (GO:0051351) | 3.30624768 |
83 | aerobic respiration (GO:0009060) | 3.29991545 |
84 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.29897482 |
85 | ribosomal small subunit biogenesis (GO:0042274) | 3.29001995 |
86 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.28587909 |
87 | cullin deneddylation (GO:0010388) | 3.26717512 |
88 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.26183782 |
89 | CENP-A containing nucleosome assembly (GO:0034080) | 3.25873240 |
90 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.24669250 |
91 | cellular component biogenesis (GO:0044085) | 3.23807248 |
92 | cell cycle G1/S phase transition (GO:0044843) | 3.23575074 |
93 | G1/S transition of mitotic cell cycle (GO:0000082) | 3.23575074 |
94 | mitotic recombination (GO:0006312) | 3.22079207 |
95 | translational initiation (GO:0006413) | 3.21432282 |
96 | cotranslational protein targeting to membrane (GO:0006613) | 3.20873213 |
97 | chromatin remodeling at centromere (GO:0031055) | 3.17460851 |
98 | ATP biosynthetic process (GO:0006754) | 3.17385895 |
99 | telomere maintenance via telomere lengthening (GO:0010833) | 3.17311308 |
100 | protein targeting to ER (GO:0045047) | 3.16833516 |
101 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.15749492 |
102 | peptidyl-histidine modification (GO:0018202) | 3.15729807 |
103 | translational termination (GO:0006415) | 3.15356800 |
104 | viral transcription (GO:0019083) | 3.14517622 |
105 | protein deneddylation (GO:0000338) | 3.14390903 |
106 | * translation (GO:0006412) | 3.14296932 |
107 | IMP metabolic process (GO:0046040) | 3.12538934 |
108 | protein localization to endoplasmic reticulum (GO:0070972) | 3.06836753 |
109 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.06636144 |
110 | mitotic nuclear envelope disassembly (GO:0007077) | 3.05207571 |
111 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.04998368 |
112 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.04062880 |
113 | tRNA aminoacylation for protein translation (GO:0006418) | 3.03823477 |
114 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.03778758 |
115 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.03380005 |
116 | protein localization to kinetochore (GO:0034501) | 3.02371087 |
117 | translational elongation (GO:0006414) | 3.00673664 |
118 | maturation of 5.8S rRNA (GO:0000460) | 3.00379420 |
119 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.00145243 |
120 | tRNA aminoacylation (GO:0043039) | 2.98251297 |
121 | amino acid activation (GO:0043038) | 2.98251297 |
122 | glycine metabolic process (GO:0006544) | 2.98094737 |
123 | nucleoside transmembrane transport (GO:1901642) | 2.98016951 |
124 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 2.97030336 |
125 | transcription initiation from RNA polymerase I promoter (GO:0006361) | 2.96221021 |
126 | tricarboxylic acid cycle (GO:0006099) | 2.96117106 |
127 | purine nucleoside monophosphate biosynthetic process (GO:0009127) | 2.95295048 |
128 | purine ribonucleoside monophosphate biosynthetic process (GO:0009168) | 2.95295048 |
129 | metaphase plate congression (GO:0051310) | 2.95258193 |
130 | protein-cofactor linkage (GO:0018065) | 2.94127315 |
131 | methionine biosynthetic process (GO:0009086) | 2.93870446 |
132 | viral mRNA export from host cell nucleus (GO:0046784) | 2.93816094 |
133 | regulation of ligase activity (GO:0051340) | 2.93628618 |
134 | DNA replication-dependent nucleosome organization (GO:0034723) | 2.93179855 |
135 | DNA replication-dependent nucleosome assembly (GO:0006335) | 2.93179855 |
136 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 2.91127246 |
137 | folic acid transport (GO:0015884) | 2.89878119 |
138 | nucleobase-containing small molecule interconversion (GO:0015949) | 2.88844620 |
139 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 2.87353597 |
140 | positive regulation of cell cycle arrest (GO:0071158) | 2.86111658 |
141 | spliceosomal complex assembly (GO:0000245) | 2.85712955 |
142 | DNA replication-independent nucleosome assembly (GO:0006336) | 2.85692366 |
143 | DNA replication-independent nucleosome organization (GO:0034724) | 2.85692366 |
Rank | Gene Set | Z-score |
---|---|---|
1 | E2F7_22180533_ChIP-Seq_HELA_Human | 5.96113438 |
2 | * MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.30480341 |
3 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.95519983 |
4 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.81951311 |
5 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.63716924 |
6 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.49275887 |
7 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.46734058 |
8 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.33618698 |
9 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.09300563 |
10 | * CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.07907892 |
11 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.96365942 |
12 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.91822479 |
13 | * MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.90974883 |
14 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.88888832 |
15 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.70160870 |
16 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.57885110 |
17 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.41415454 |
18 | * FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.41057491 |
19 | * CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.32676065 |
20 | * NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.29430505 |
21 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.28545910 |
22 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.25191938 |
23 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.23895753 |
24 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.20215905 |
25 | * XRN2_22483619_ChIP-Seq_HELA_Human | 2.20196294 |
26 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.18881618 |
27 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.08871115 |
28 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.04330512 |
29 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.03750981 |
30 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.01320020 |
31 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.97795135 |
32 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.95418720 |
33 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.92038226 |
34 | * POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.85320513 |
35 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.84794189 |
36 | * MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.81910233 |
37 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.80192137 |
38 | * PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.78469350 |
39 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.75466944 |
40 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.72444661 |
41 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.71757718 |
42 | * MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.70752604 |
43 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.68974623 |
44 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.63827630 |
45 | * ELK1_19687146_ChIP-ChIP_HELA_Human | 1.58082451 |
46 | * ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.56162134 |
47 | * YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.50070754 |
48 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.48089617 |
49 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.45864467 |
50 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.45526573 |
51 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.41852094 |
52 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.41825755 |
53 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.41210822 |
54 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.41136372 |
55 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.40465724 |
56 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.37633626 |
57 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.36626007 |
58 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.33293023 |
59 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.30338673 |
60 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.26283054 |
61 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.24416361 |
62 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.23088117 |
63 | * BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.21537276 |
64 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.19777353 |
65 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.17551378 |
66 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.15547991 |
67 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.14812550 |
68 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.14426307 |
69 | * KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.14303783 |
70 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.13826037 |
71 | * ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.12932203 |
72 | * CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.11130078 |
73 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.07029528 |
74 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.06531082 |
75 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.01968993 |
76 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.00072189 |
77 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.98838983 |
78 | * DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.97218414 |
79 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.95151789 |
80 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.94965310 |
81 | * KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.93636580 |
82 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 0.93480299 |
83 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.93430014 |
84 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.92245782 |
85 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.91747880 |
86 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.88325951 |
87 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.88322773 |
88 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.88255672 |
89 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.88116999 |
90 | * OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.87781834 |
91 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.86594743 |
92 | * KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.86368129 |
93 | * SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.85537553 |
94 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.84869456 |
95 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.84630327 |
96 | MYC_22102868_ChIP-Seq_BL_Human | 0.83786690 |
97 | * SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.83365441 |
98 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.82292117 |
99 | * SPI1_23547873_ChIP-Seq_NB4_Human | 0.82204613 |
100 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 0.81258828 |
101 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 0.81150103 |
102 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.80538682 |
103 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.78779889 |
104 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.78092944 |
105 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.77291150 |
106 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.77060392 |
107 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.76363358 |
108 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.75495017 |
109 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.75369791 |
110 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.73346478 |
111 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.73290363 |
112 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.70898490 |
113 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.69861996 |
114 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.69661733 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0003693_abnormal_embryo_hatching | 6.07715365 |
2 | MP0004957_abnormal_blastocyst_morpholog | 4.47998879 |
3 | MP0003111_abnormal_nucleus_morphology | 4.41233303 |
4 | MP0003806_abnormal_nucleotide_metabolis | 4.33658639 |
5 | MP0010094_abnormal_chromosome_stability | 4.06277601 |
6 | MP0003077_abnormal_cell_cycle | 3.61456506 |
7 | MP0008058_abnormal_DNA_repair | 3.41444866 |
8 | MP0008057_abnormal_DNA_replication | 3.29998303 |
9 | MP0000372_irregular_coat_pigmentation | 3.09771808 |
10 | MP0003718_maternal_effect | 2.69749666 |
11 | MP0008932_abnormal_embryonic_tissue | 2.56715725 |
12 | MP0008007_abnormal_cellular_replicative | 2.55339216 |
13 | MP0003186_abnormal_redox_activity | 2.38534410 |
14 | MP0003786_premature_aging | 2.38174586 |
15 | MP0002396_abnormal_hematopoietic_system | 2.10316670 |
16 | MP0001730_embryonic_growth_arrest | 2.08187077 |
17 | MP0006036_abnormal_mitochondrial_physio | 2.02708672 |
18 | MP0009840_abnormal_foam_cell | 1.95662360 |
19 | MP0002837_dystrophic_cardiac_calcinosis | 1.87688783 |
20 | MP0008995_early_reproductive_senescence | 1.84150647 |
21 | MP0001529_abnormal_vocalization | 1.79043063 |
22 | MP0000350_abnormal_cell_proliferation | 1.74444564 |
23 | MP0006035_abnormal_mitochondrial_morpho | 1.74053524 |
24 | MP0009333_abnormal_splenocyte_physiolog | 1.72418262 |
25 | MP0001764_abnormal_homeostasis | 1.68486795 |
26 | MP0008260_abnormal_autophagy | 1.64151224 |
27 | MP0004145_abnormal_muscle_electrophysio | 1.61242795 |
28 | MP0003123_paternal_imprinting | 1.61037875 |
29 | MP0000490_abnormal_crypts_of | 1.51597495 |
30 | MP0005408_hypopigmentation | 1.48436117 |
31 | MP0000358_abnormal_cell_content/ | 1.45132238 |
32 | MP0002163_abnormal_gland_morphology | 1.44347153 |
33 | MP0009379_abnormal_foot_pigmentation | 1.43967690 |
34 | MP0001672_abnormal_embryogenesis/_devel | 1.43555797 |
35 | MP0005380_embryogenesis_phenotype | 1.43555797 |
36 | MP0006072_abnormal_retinal_apoptosis | 1.42078439 |
37 | MP0010307_abnormal_tumor_latency | 1.41201750 |
38 | MP0010352_gastrointestinal_tract_polyps | 1.40101041 |
39 | MP0000749_muscle_degeneration | 1.39937378 |
40 | MP0001697_abnormal_embryo_size | 1.39460993 |
41 | MP0002938_white_spotting | 1.39297622 |
42 | MP0002080_prenatal_lethality | 1.37751879 |
43 | MP0006292_abnormal_olfactory_placode | 1.36113562 |
44 | MP0000751_myopathy | 1.32098352 |
45 | MP0000313_abnormal_cell_death | 1.31661533 |
46 | MP0002139_abnormal_hepatobiliary_system | 1.30485615 |
47 | MP0003984_embryonic_growth_retardation | 1.29270404 |
48 | MP0002019_abnormal_tumor_incidence | 1.29081491 |
49 | MP0008877_abnormal_DNA_methylation | 1.26813250 |
50 | MP0002132_abnormal_respiratory_system | 1.26630624 |
51 | MP0002088_abnormal_embryonic_growth/wei | 1.25404891 |
52 | MP0005330_cardiomyopathy | 1.23583043 |
53 | MP0003656_abnormal_erythrocyte_physiolo | 1.22293557 |
54 | MP0001853_heart_inflammation | 1.22110103 |
55 | MP0002234_abnormal_pharynx_morphology | 1.21447277 |
56 | MP0005332_abnormal_amino_acid | 1.20215199 |
57 | MP0005075_abnormal_melanosome_morpholog | 1.19604958 |
58 | MP0005397_hematopoietic_system_phenotyp | 1.18307585 |
59 | MP0001545_abnormal_hematopoietic_system | 1.18307585 |
60 | MP0005085_abnormal_gallbladder_physiolo | 1.13500458 |
61 | MP0008789_abnormal_olfactory_epithelium | 1.11590718 |
62 | MP0009697_abnormal_copulation | 1.10793146 |
63 | MP0003315_abnormal_perineum_morphology | 1.10612615 |
64 | MP0005379_endocrine/exocrine_gland_phen | 1.08731952 |
65 | MP0005266_abnormal_metabolism | 1.05814192 |
66 | MP0002210_abnormal_sex_determination | 1.05410208 |
67 | MP0005360_urolithiasis | 1.04619783 |
68 | MP0003567_abnormal_fetal_cardiomyocyte | 1.04439096 |
69 | MP0005645_abnormal_hypothalamus_physiol | 1.03759541 |
70 | MP0005319_abnormal_enzyme/_coenzyme | 1.02247800 |
71 | MP0005365_abnormal_bile_salt | 1.01489141 |
72 | MP0001145_abnormal_male_reproductive | 1.00634158 |
73 | MP0000678_abnormal_parathyroid_gland | 0.99382169 |
74 | MP0002638_abnormal_pupillary_reflex | 0.99340494 |
75 | MP0005389_reproductive_system_phenotype | 0.98754252 |
76 | MP0002160_abnormal_reproductive_system | 0.98520545 |
77 | MP0005410_abnormal_fertilization | 0.97311695 |
78 | MP0001542_abnormal_bone_strength | 0.96165473 |
79 | MP0003221_abnormal_cardiomyocyte_apopto | 0.95903448 |
80 | MP0002086_abnormal_extraembryonic_tissu | 0.95740391 |
81 | MP0008872_abnormal_physiological_respon | 0.95714030 |
82 | MP0003011_delayed_dark_adaptation | 0.95610378 |
83 | MP0002085_abnormal_embryonic_tissue | 0.94539842 |
84 | MP0004019_abnormal_vitamin_homeostasis | 0.91937837 |
85 | MP0008775_abnormal_heart_ventricle | 0.91823158 |
86 | MP0001881_abnormal_mammary_gland | 0.91792618 |
87 | MP0005395_other_phenotype | 0.91418443 |
88 | MP0001905_abnormal_dopamine_level | 0.89663205 |
89 | MP0000747_muscle_weakness | 0.89540755 |
90 | MP0003646_muscle_fatigue | 0.89456253 |
91 | MP0001929_abnormal_gametogenesis | 0.87675851 |
92 | MP0000689_abnormal_spleen_morphology | 0.86827181 |
93 | MP0002095_abnormal_skin_pigmentation | 0.85746323 |
94 | MP0004147_increased_porphyrin_level | 0.84650195 |
95 | MP0002722_abnormal_immune_system | 0.84567517 |
96 | MP0001661_extended_life_span | 0.83917911 |
97 | MP0002102_abnormal_ear_morphology | 0.83285635 |
98 | MP0000653_abnormal_sex_gland | 0.83113239 |
99 | MP0000598_abnormal_liver_morphology | 0.82028557 |
100 | MP0002106_abnormal_muscle_physiology | 0.80471642 |
101 | MP0005384_cellular_phenotype | 0.80266075 |
102 | MP0003698_abnormal_male_reproductive | 0.80263822 |
103 | MP0005376_homeostasis/metabolism_phenot | 0.78062449 |
104 | MP0002269_muscular_atrophy | 0.76605816 |
105 | MP0001727_abnormal_embryo_implantation | 0.75147064 |
106 | MP0004197_abnormal_fetal_growth/weight/ | 0.75084955 |
107 | MP0004215_abnormal_myocardial_fiber | 0.75077074 |
108 | MP0005646_abnormal_pituitary_gland | 0.74801333 |
109 | MP0000750_abnormal_muscle_regeneration | 0.74704633 |
110 | MP0003763_abnormal_thymus_physiology | 0.73218709 |
111 | MP0001119_abnormal_female_reproductive | 0.73155390 |
112 | MP0005451_abnormal_body_composition | 0.72633210 |
113 | MP0000609_abnormal_liver_physiology | 0.72122659 |
114 | MP0000858_altered_metastatic_potential | 0.71960930 |
115 | MP0008875_abnormal_xenobiotic_pharmacok | 0.70093163 |
116 | MP0002429_abnormal_blood_cell | 0.69515533 |
117 | MP0002084_abnormal_developmental_patter | 0.69421992 |
118 | MP0002398_abnormal_bone_marrow | 0.69406443 |
119 | MP0005253_abnormal_eye_physiology | 0.69405601 |
120 | MP0001919_abnormal_reproductive_system | 0.68254733 |
121 | MP0003195_calcinosis | 0.67963646 |
122 | MP0005083_abnormal_biliary_tract | 0.67409553 |
123 | MP0002090_abnormal_vision | 0.67103759 |
124 | MP0004233_abnormal_muscle_weight | 0.66442334 |
125 | MP0005621_abnormal_cell_physiology | 0.66007944 |
126 | MP0005670_abnormal_white_adipose | 0.65688366 |
127 | MP0008469_abnormal_protein_level | 0.64874864 |
128 | MP0003137_abnormal_impulse_conducting | 0.64511114 |
129 | MP0005551_abnormal_eye_electrophysiolog | 0.64433195 |
130 | MP0004808_abnormal_hematopoietic_stem | 0.63173429 |
131 | MP0005636_abnormal_mineral_homeostasis | 0.62941921 |
132 | MP0000015_abnormal_ear_pigmentation | 0.62781083 |
133 | MP0003890_abnormal_embryonic-extraembry | 0.61872410 |
134 | MP0009643_abnormal_urine_homeostasis | 0.61773792 |
135 | MP0000703_abnormal_thymus_morphology | 0.61361769 |
136 | MP0001756_abnormal_urination | 0.61176478 |
137 | MP0004133_heterotaxia | 0.61054571 |
138 | MP0001293_anophthalmia | 0.60452588 |
139 | MP0002161_abnormal_fertility/fecundity | 0.60120570 |
140 | MP0002736_abnormal_nociception_after | 0.60009404 |
141 | MP0009672_abnormal_birth_weight | 0.59457670 |
142 | MP0009785_altered_susceptibility_to | 0.58424325 |
143 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.58344736 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Birth length less than 3rd percentile (HP:0003561) | 5.14571128 |
2 | Progressive macrocephaly (HP:0004481) | 4.36648918 |
3 | Breast hypoplasia (HP:0003187) | 4.26889102 |
4 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.91655636 |
5 | Abnormal number of erythroid precursors (HP:0012131) | 3.88751727 |
6 | Increased intramyocellular lipid droplets (HP:0012240) | 3.76615734 |
7 | Rough bone trabeculation (HP:0100670) | 3.76339805 |
8 | Cerebral hypomyelination (HP:0006808) | 3.70683414 |
9 | Reticulocytopenia (HP:0001896) | 3.57197022 |
10 | Oral leukoplakia (HP:0002745) | 3.53526203 |
11 | Carpal bone hypoplasia (HP:0001498) | 3.46870833 |
12 | Renal Fanconi syndrome (HP:0001994) | 3.43500655 |
13 | Increased muscle lipid content (HP:0009058) | 3.26687861 |
14 | Multiple enchondromatosis (HP:0005701) | 3.25616989 |
15 | Abnormality of the anterior horn cell (HP:0006802) | 3.17545916 |
16 | Degeneration of anterior horn cells (HP:0002398) | 3.17545916 |
17 | Increased serum lactate (HP:0002151) | 3.11250629 |
18 | Hyperglycinemia (HP:0002154) | 3.09409770 |
19 | 3-Methylglutaconic aciduria (HP:0003535) | 3.03842527 |
20 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.02828226 |
21 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.02828226 |
22 | Microvesicular hepatic steatosis (HP:0001414) | 3.02466018 |
23 | Hepatic necrosis (HP:0002605) | 3.02380168 |
24 | Macrocytic anemia (HP:0001972) | 2.98103478 |
25 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.96376804 |
26 | Abnormality of alanine metabolism (HP:0010916) | 2.96376804 |
27 | Hyperalaninemia (HP:0003348) | 2.96376804 |
28 | Hepatocellular necrosis (HP:0001404) | 2.94593053 |
29 | Aplastic anemia (HP:0001915) | 2.93823396 |
30 | Secondary amenorrhea (HP:0000869) | 2.89690228 |
31 | Premature ovarian failure (HP:0008209) | 2.88479838 |
32 | Increased CSF lactate (HP:0002490) | 2.81710992 |
33 | Progressive muscle weakness (HP:0003323) | 2.81439155 |
34 | Abnormality of pyrimidine metabolism (HP:0004353) | 2.79239931 |
35 | Megaloblastic anemia (HP:0001889) | 2.78195038 |
36 | Methylmalonic acidemia (HP:0002912) | 2.76881612 |
37 | Hyperglycinuria (HP:0003108) | 2.73921344 |
38 | Increased serum pyruvate (HP:0003542) | 2.73828133 |
39 | Abnormality of glycolysis (HP:0004366) | 2.73828133 |
40 | Methylmalonic aciduria (HP:0012120) | 2.72698251 |
41 | Ragged-red muscle fibers (HP:0003200) | 2.72248401 |
42 | Microretrognathia (HP:0000308) | 2.72057250 |
43 | Abnormal trabecular bone morphology (HP:0100671) | 2.67660886 |
44 | Acute necrotizing encephalopathy (HP:0006965) | 2.65583156 |
45 | Type I transferrin isoform profile (HP:0003642) | 2.65007854 |
46 | Patellar aplasia (HP:0006443) | 2.63406777 |
47 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.63022475 |
48 | Mitochondrial inheritance (HP:0001427) | 2.62743179 |
49 | Abnormality of serum amino acid levels (HP:0003112) | 2.60093818 |
50 | Trismus (HP:0000211) | 2.58827612 |
51 | Emotional lability (HP:0000712) | 2.58604833 |
52 | Impulsivity (HP:0100710) | 2.55882522 |
53 | CNS demyelination (HP:0007305) | 2.53685070 |
54 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.50706872 |
55 | Respiratory difficulties (HP:0002880) | 2.50186290 |
56 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.49910842 |
57 | Abnormality of methionine metabolism (HP:0010901) | 2.45909633 |
58 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.41703174 |
59 | Ureteral duplication (HP:0000073) | 2.41604902 |
60 | Acute encephalopathy (HP:0006846) | 2.40810649 |
61 | Lactic acidosis (HP:0003128) | 2.40702375 |
62 | Bone marrow hypocellularity (HP:0005528) | 2.40473403 |
63 | Generalized aminoaciduria (HP:0002909) | 2.40448912 |
64 | Abnormality of serine family amino acid metabolism (HP:0010894) | 2.39992910 |
65 | Abnormality of glycine metabolism (HP:0010895) | 2.39992910 |
66 | Abnormality of the preputium (HP:0100587) | 2.39070848 |
67 | Pallor (HP:0000980) | 2.38376488 |
68 | Premature graying of hair (HP:0002216) | 2.38187035 |
69 | Abnormality of chromosome stability (HP:0003220) | 2.37936835 |
70 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.36184070 |
71 | Optic disc pallor (HP:0000543) | 2.34796168 |
72 | Increased hepatocellular lipid droplets (HP:0006565) | 2.34758321 |
73 | Pancytopenia (HP:0001876) | 2.34651226 |
74 | Selective tooth agenesis (HP:0001592) | 2.32755637 |
75 | Nausea (HP:0002018) | 2.32500480 |
76 | Leukodystrophy (HP:0002415) | 2.31536076 |
77 | Abnormal spermatogenesis (HP:0008669) | 2.29594075 |
78 | Lethargy (HP:0001254) | 2.29054856 |
79 | Sparse eyelashes (HP:0000653) | 2.28935966 |
80 | Meckel diverticulum (HP:0002245) | 2.28584751 |
81 | CNS hypomyelination (HP:0003429) | 2.28316863 |
82 | Lipid accumulation in hepatocytes (HP:0006561) | 2.28276264 |
83 | Rhabdomyolysis (HP:0003201) | 2.28004425 |
84 | Chromsome breakage (HP:0040012) | 2.27566141 |
85 | Absent thumb (HP:0009777) | 2.26575249 |
86 | Abnormality of the umbilical cord (HP:0010881) | 2.22192308 |
87 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.21668568 |
88 | Cerebral edema (HP:0002181) | 2.20881949 |
89 | Reduced antithrombin III activity (HP:0001976) | 2.20546086 |
90 | Cellular immunodeficiency (HP:0005374) | 2.18974287 |
91 | Poor head control (HP:0002421) | 2.18076391 |
92 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 2.15256180 |
93 | Abnormality of the ileum (HP:0001549) | 2.15139480 |
94 | Abnormal gallbladder physiology (HP:0012438) | 2.13612839 |
95 | Cholecystitis (HP:0001082) | 2.13612839 |
96 | Absent radius (HP:0003974) | 2.12061832 |
97 | Death in infancy (HP:0001522) | 2.11888232 |
98 | Colon cancer (HP:0003003) | 2.10534016 |
99 | Dicarboxylic aciduria (HP:0003215) | 2.08798826 |
100 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.08798826 |
101 | Prolonged neonatal jaundice (HP:0006579) | 2.07859051 |
102 | Nemaline bodies (HP:0003798) | 2.06692137 |
103 | Glycosuria (HP:0003076) | 2.05071116 |
104 | Abnormality of urine glucose concentration (HP:0011016) | 2.05071116 |
105 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.04750075 |
106 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.01548847 |
107 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.01548847 |
108 | Abnormal protein glycosylation (HP:0012346) | 2.01548847 |
109 | Abnormal glycosylation (HP:0012345) | 2.01548847 |
110 | Myoglobinuria (HP:0002913) | 2.00386901 |
111 | Hypobetalipoproteinemia (HP:0003563) | 2.00035783 |
112 | Agnosia (HP:0010524) | 1.99368261 |
113 | Muscle fiber inclusion bodies (HP:0100299) | 1.98521970 |
114 | Horseshoe kidney (HP:0000085) | 1.97613522 |
115 | Exercise intolerance (HP:0003546) | 1.97518707 |
116 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.96601012 |
117 | Respiratory failure (HP:0002878) | 1.95377091 |
118 | Ketoacidosis (HP:0001993) | 1.94039658 |
119 | Exertional dyspnea (HP:0002875) | 1.93885548 |
120 | Opisthotonus (HP:0002179) | 1.93593266 |
121 | Hypoglycemic coma (HP:0001325) | 1.93494627 |
122 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 1.93241810 |
123 | Absent forearm bone (HP:0003953) | 1.92963705 |
124 | Aplasia involving forearm bones (HP:0009822) | 1.92963705 |
125 | Neoplasm of the pancreas (HP:0002894) | 1.91057318 |
126 | Testicular atrophy (HP:0000029) | 1.90267501 |
127 | Gliosis (HP:0002171) | 1.89550081 |
128 | Gout (HP:0001997) | 1.88686708 |
129 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 1.86808923 |
130 | Hyperammonemia (HP:0001987) | 1.85981406 |
131 | Abnormality of renal resorption (HP:0011038) | 1.84723772 |
132 | Delayed CNS myelination (HP:0002188) | 1.80128923 |
133 | Exercise-induced muscle cramps (HP:0003710) | 1.80078304 |
134 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 1.78721941 |
135 | Type 2 muscle fiber atrophy (HP:0003554) | 1.77045253 |
136 | Ketosis (HP:0001946) | 1.76741788 |
137 | X-linked dominant inheritance (HP:0001423) | 1.75458530 |
138 | Metabolic acidosis (HP:0001942) | 1.75448614 |
139 | Abnormality of fatty-acid metabolism (HP:0004359) | 1.72937421 |
Rank | Gene Set | Z-score |
---|---|---|
1 | BUB1 | 5.26062456 |
2 | VRK2 | 4.53689671 |
3 | WEE1 | 4.52934050 |
4 | EIF2AK1 | 3.67015826 |
5 | STK16 | 3.20854533 |
6 | NME2 | 3.16538282 |
7 | TSSK6 | 2.90776733 |
8 | BRSK2 | 2.83491202 |
9 | EIF2AK3 | 2.81378008 |
10 | PLK4 | 2.51645446 |
11 | EPHA2 | 2.40371535 |
12 | LIMK1 | 2.32396053 |
13 | CDC7 | 2.29183402 |
14 | NEK1 | 2.21118267 |
15 | SRPK1 | 2.19288208 |
16 | BCKDK | 1.92048662 |
17 | PIM2 | 1.89071223 |
18 | TTK | 1.88905541 |
19 | PLK1 | 1.80779554 |
20 | NEK2 | 1.80042968 |
21 | VRK1 | 1.71198730 |
22 | BRSK1 | 1.66081614 |
23 | OBSCN | 1.61959856 |
24 | ACVR1B | 1.58275216 |
25 | TESK2 | 1.57837697 |
26 | ZAK | 1.56484448 |
27 | PLK3 | 1.49885360 |
28 | NUAK1 | 1.48755814 |
29 | IRAK3 | 1.45957177 |
30 | PDK4 | 1.43680783 |
31 | PDK3 | 1.43680783 |
32 | NME1 | 1.35350479 |
33 | AURKB | 1.35252691 |
34 | AURKA | 1.34029117 |
35 | DYRK3 | 1.31679006 |
36 | ATR | 1.26938407 |
37 | AKT3 | 1.26887993 |
38 | TRIM28 | 1.24912179 |
39 | PHKG2 | 1.24618185 |
40 | PHKG1 | 1.24618185 |
41 | MAP4K2 | 1.18851731 |
42 | CDK7 | 1.17208516 |
43 | PDK2 | 1.15516088 |
44 | CHEK2 | 1.14958071 |
45 | CCNB1 | 1.13110064 |
46 | RPS6KA4 | 1.11760745 |
47 | TLK1 | 1.09869168 |
48 | RPS6KB2 | 1.08509303 |
49 | PASK | 1.07773609 |
50 | BRAF | 1.05951217 |
51 | MAP3K11 | 1.03947767 |
52 | FLT3 | 1.03083973 |
53 | MKNK1 | 0.98890049 |
54 | CDK4 | 0.97953861 |
55 | MAP3K8 | 0.95866671 |
56 | ARAF | 0.95465403 |
57 | TAF1 | 0.94594320 |
58 | EIF2AK2 | 0.93979875 |
59 | KDR | 0.93959007 |
60 | CSNK1G3 | 0.86883420 |
61 | MAP3K3 | 0.82002810 |
62 | MAP3K12 | 0.81238563 |
63 | MKNK2 | 0.79791316 |
64 | ABL2 | 0.79220255 |
65 | CHEK1 | 0.79071979 |
66 | PIM1 | 0.77719666 |
67 | CSNK2A1 | 0.76932884 |
68 | PINK1 | 0.75594299 |
69 | MUSK | 0.74630948 |
70 | PBK | 0.73363853 |
71 | SCYL2 | 0.72373192 |
72 | PRKCI | 0.71901920 |
73 | CSNK2A2 | 0.71412463 |
74 | IRAK4 | 0.71403939 |
75 | CLK1 | 0.71094093 |
76 | WNK3 | 0.67607073 |
77 | PAK1 | 0.67368675 |
78 | PNCK | 0.63743754 |
79 | PAK4 | 0.63584749 |
80 | STK10 | 0.63430632 |
81 | CSNK1G1 | 0.62147863 |
82 | CDK8 | 0.61914018 |
83 | STK4 | 0.61389035 |
84 | MAP2K7 | 0.60709510 |
85 | STK38L | 0.60181881 |
86 | MAP2K3 | 0.59787346 |
87 | MST1R | 0.59759793 |
88 | MST4 | 0.59304454 |
89 | MAPKAPK3 | 0.57225298 |
90 | TESK1 | 0.56031521 |
91 | GRK1 | 0.52835112 |
92 | TAOK2 | 0.50863789 |
93 | CSNK1G2 | 0.50149081 |
94 | * CDK2 | 0.49693900 |
95 | MAP2K6 | 0.48885156 |
96 | CSNK1A1L | 0.48142302 |
97 | ATM | 0.45314634 |
98 | DAPK3 | 0.45135522 |
99 | MARK3 | 0.43492523 |
100 | MAPKAPK5 | 0.43206030 |
101 | INSRR | 0.39116801 |
102 | IKBKB | 0.39083807 |
103 | ADRBK2 | 0.38010570 |
104 | RPS6KA5 | 0.36874944 |
105 | MAP4K1 | 0.36816710 |
106 | DYRK2 | 0.36486679 |
107 | DAPK1 | 0.33090402 |
108 | LRRK2 | 0.32911833 |
109 | WNK4 | 0.32197130 |
110 | CDK1 | 0.31868126 |
111 | TGFBR1 | 0.29696427 |
112 | KIT | 0.29197842 |
113 | MAP3K5 | 0.27763309 |
114 | CSNK1A1 | 0.27363726 |
115 | ZAP70 | 0.26967897 |
116 | CAMK2G | 0.26540189 |
117 | ALK | 0.25580345 |
118 | ILK | 0.22902397 |
119 | TIE1 | 0.22467369 |
120 | STK24 | 0.22440538 |
121 | MAPK11 | 0.22307797 |
122 | MELK | 0.21936361 |
123 | TYK2 | 0.20828433 |
124 | CSNK1E | 0.20380179 |
125 | CDK6 | 0.20182993 |
126 | MAPKAPK2 | 0.19457158 |
127 | NEK9 | 0.19156921 |
128 | RPS6KB1 | 0.18577958 |
129 | MYLK | 0.15810281 |
130 | AKT2 | 0.14005067 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Proteasome_Homo sapiens_hsa03050 | 4.38635643 |
2 | DNA replication_Homo sapiens_hsa03030 | 3.85936490 |
3 | RNA polymerase_Homo sapiens_hsa03020 | 3.73748509 |
4 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.48773435 |
5 | Ribosome_Homo sapiens_hsa03010 | 3.31352400 |
6 | Mismatch repair_Homo sapiens_hsa03430 | 3.23431833 |
7 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.68232268 |
8 | RNA transport_Homo sapiens_hsa03013 | 2.60997999 |
9 | Spliceosome_Homo sapiens_hsa03040 | 2.46600521 |
10 | Homologous recombination_Homo sapiens_hsa03440 | 2.38848048 |
11 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.36321344 |
12 | Base excision repair_Homo sapiens_hsa03410 | 2.31484505 |
13 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.30720282 |
14 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.27098345 |
15 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 2.20265927 |
16 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.80769812 |
17 | Cell cycle_Homo sapiens_hsa04110 | 1.70935959 |
18 | Basal transcription factors_Homo sapiens_hsa03022 | 1.61654469 |
19 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.56696608 |
20 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.51938966 |
21 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.51146830 |
22 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.51094282 |
23 | Purine metabolism_Homo sapiens_hsa00230 | 1.45928859 |
24 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.45274207 |
25 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.44890860 |
26 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.44613298 |
27 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.43931228 |
28 | Protein export_Homo sapiens_hsa03060 | 1.42957925 |
29 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.39500302 |
30 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.35144668 |
31 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.34843426 |
32 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.34511907 |
33 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.34321764 |
34 | RNA degradation_Homo sapiens_hsa03018 | 1.33833713 |
35 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.31668494 |
36 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.29492248 |
37 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.27066506 |
38 | Sulfur relay system_Homo sapiens_hsa04122 | 1.23277156 |
39 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.20844435 |
40 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.20103713 |
41 | Carbon metabolism_Homo sapiens_hsa01200 | 1.18493094 |
42 | Parkinsons disease_Homo sapiens_hsa05012 | 1.15714749 |
43 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.13715358 |
44 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.05855518 |
45 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.03811139 |
46 | Huntingtons disease_Homo sapiens_hsa05016 | 1.03275490 |
47 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.01854269 |
48 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.99623161 |
49 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.97623113 |
50 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.93230442 |
51 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.93079983 |
52 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.90231326 |
53 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.79379514 |
54 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.73715379 |
55 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.71983316 |
56 | Metabolic pathways_Homo sapiens_hsa01100 | 0.69943269 |
57 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.68737533 |
58 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.65767706 |
59 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.65463074 |
60 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.63780686 |
61 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.63541293 |
62 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.61071984 |
63 | Galactose metabolism_Homo sapiens_hsa00052 | 0.60951001 |
64 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.58387882 |
65 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.57640886 |
66 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.54541711 |
67 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.53275361 |
68 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.52454430 |
69 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.51622338 |
70 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.51533559 |
71 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.50793947 |
72 | Peroxisome_Homo sapiens_hsa04146 | 0.50614881 |
73 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.50458424 |
74 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.48982447 |
75 | Legionellosis_Homo sapiens_hsa05134 | 0.48897083 |
76 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.46689497 |
77 | Alzheimers disease_Homo sapiens_hsa05010 | 0.45947893 |
78 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.42930607 |
79 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.42228694 |
80 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.41061844 |
81 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.39736645 |
82 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.39218283 |
83 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.38303374 |
84 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.37830324 |
85 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.37575382 |
86 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.36088710 |
87 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.34927476 |
88 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.34478381 |
89 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.34226129 |
90 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.34029403 |
91 | Retinol metabolism_Homo sapiens_hsa00830 | 0.32205687 |
92 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.30972424 |
93 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.29194129 |
94 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.24632861 |
95 | Histidine metabolism_Homo sapiens_hsa00340 | 0.24275286 |
96 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.24241049 |
97 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.24150692 |
98 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.23511076 |
99 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.21377644 |
100 | Phototransduction_Homo sapiens_hsa04744 | 0.20739873 |
101 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.19491480 |
102 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.18111214 |
103 | * Viral carcinogenesis_Homo sapiens_hsa05203 | 0.18004296 |
104 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.17961817 |
105 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.16926228 |
106 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.16484611 |
107 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.15974128 |
108 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.15503226 |
109 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.15472320 |
110 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.10732136 |