MRPS18C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. Pseudogenes corresponding to this gene are found on chromosomes 8p, 12p, 15q, and 22q. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.93387402
2ATP synthesis coupled proton transport (GO:0015986)6.67994473
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.67994473
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.35665378
5protein neddylation (GO:0045116)5.51934901
6respiratory electron transport chain (GO:0022904)5.45812733
7electron transport chain (GO:0022900)5.30981974
8ribosomal small subunit biogenesis (GO:0042274)4.85576661
9proteasome assembly (GO:0043248)4.84050342
10chaperone-mediated protein transport (GO:0072321)4.61136273
11central nervous system myelination (GO:0022010)4.38231436
12axon ensheathment in central nervous system (GO:0032291)4.38231436
13protein complex biogenesis (GO:0070271)4.25325170
14viral transcription (GO:0019083)4.24554393
15ribosomal small subunit assembly (GO:0000028)4.13907442
16GTP biosynthetic process (GO:0006183)4.13622315
17mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.11392424
18mitochondrial respiratory chain complex I assembly (GO:0032981)4.11392424
19NADH dehydrogenase complex assembly (GO:0010257)4.11392424
20translational termination (GO:0006415)4.09254129
21cotranslational protein targeting to membrane (GO:0006613)4.05518588
22termination of RNA polymerase III transcription (GO:0006386)3.99720189
23transcription elongation from RNA polymerase III promoter (GO:0006385)3.99720189
24SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.95567649
25protein targeting to ER (GO:0045047)3.95403926
26chromatin remodeling at centromere (GO:0031055)3.93764789
27establishment of protein localization to mitochondrial membrane (GO:0090151)3.92696185
28CENP-A containing nucleosome assembly (GO:0034080)3.89862625
29protein localization to endoplasmic reticulum (GO:0070972)3.83791289
30establishment of protein localization to endoplasmic reticulum (GO:0072599)3.78353996
31mitochondrial respiratory chain complex assembly (GO:0033108)3.76154241
32ribosomal large subunit biogenesis (GO:0042273)3.71916759
337-methylguanosine mRNA capping (GO:0006370)3.69180955
34RNA capping (GO:0036260)3.69007295
357-methylguanosine RNA capping (GO:0009452)3.69007295
36spliceosomal snRNP assembly (GO:0000387)3.68481765
37respiratory chain complex IV assembly (GO:0008535)3.67724648
38oxidative phosphorylation (GO:0006119)3.61099262
39RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.59409471
40tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.59409471
41regulation of mitochondrial translation (GO:0070129)3.57533420
42maturation of SSU-rRNA (GO:0030490)3.56967032
43establishment of integrated proviral latency (GO:0075713)3.56633660
44long-chain fatty acid biosynthetic process (GO:0042759)3.54959632
45fatty acid elongation (GO:0030497)3.54714116
46GPI anchor biosynthetic process (GO:0006506)3.54383691
47regulation of cellular amino acid metabolic process (GO:0006521)3.49694714
48protein-cofactor linkage (GO:0018065)3.48313934
49negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.46133574
50establishment of viral latency (GO:0019043)3.40680981
51protein targeting to mitochondrion (GO:0006626)3.39208798
52pseudouridine synthesis (GO:0001522)3.38189790
53water-soluble vitamin biosynthetic process (GO:0042364)3.38066231
54inner mitochondrial membrane organization (GO:0007007)3.34814069
55UTP biosynthetic process (GO:0006228)3.33772473
56antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.33349047
57DNA double-strand break processing (GO:0000729)3.32249552
58hydrogen ion transmembrane transport (GO:1902600)3.30982688
59cytochrome complex assembly (GO:0017004)3.30296705
60* translation (GO:0006412)3.29991087
61histone mRNA metabolic process (GO:0008334)3.29249611
62purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.28109026
63DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.27547517
64transcription elongation from RNA polymerase I promoter (GO:0006362)3.26778104
65translational elongation (GO:0006414)3.26623378
66viral life cycle (GO:0019058)3.26260835
67establishment of protein localization to mitochondrion (GO:0072655)3.25598221
68cellular protein complex disassembly (GO:0043624)3.22849207
69histone exchange (GO:0043486)3.22784457
70negative regulation of ligase activity (GO:0051352)3.22313375
71negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.22313375
72purine nucleoside triphosphate biosynthetic process (GO:0009145)3.21939432
73positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.20910206
74signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.19452120
75signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.19452120
76signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.19452120
77intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.19365559
78signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.19365559
79nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.19297906
80protein deneddylation (GO:0000338)3.19233231
81peptidyl-histidine modification (GO:0018202)3.16123484
82GPI anchor metabolic process (GO:0006505)3.14879812
83regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.14542717
84regulation of mitotic spindle checkpoint (GO:1903504)3.14542717
85guanosine-containing compound biosynthetic process (GO:1901070)3.14019197
86antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.13543343
87maturation of 5.8S rRNA (GO:0000460)3.12552246
88positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.12059867
89intracellular protein transmembrane import (GO:0044743)3.11830146
90DNA deamination (GO:0045006)3.10589106
91spliceosomal complex assembly (GO:0000245)3.09338198
92positive regulation of ligase activity (GO:0051351)3.09149024
93organelle disassembly (GO:1903008)3.08412857
94rRNA methylation (GO:0031167)3.08123443
95proton transport (GO:0015992)3.06832616
96DNA replication checkpoint (GO:0000076)3.06335468
97rRNA processing (GO:0006364)3.05530831
98signal transduction involved in DNA integrity checkpoint (GO:0072401)3.04759783
99signal transduction involved in DNA damage checkpoint (GO:0072422)3.04759783
100termination of RNA polymerase I transcription (GO:0006363)3.04355546
101exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.04290508
102mannosylation (GO:0097502)3.03792941
103ATP biosynthetic process (GO:0006754)3.03676657
104regulation of helicase activity (GO:0051095)3.03195485
105signal transduction involved in cell cycle checkpoint (GO:0072395)3.02221852
106dopamine transport (GO:0015872)3.00638680
107DNA damage response, detection of DNA damage (GO:0042769)2.98875510
108protein localization to mitochondrion (GO:0070585)2.98385769
109regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.98112278
110hydrogen transport (GO:0006818)2.98018542
111rRNA metabolic process (GO:0016072)2.96202495
112mitochondrial transport (GO:0006839)2.95790108
113cullin deneddylation (GO:0010388)2.95498604
114rRNA modification (GO:0000154)2.94764460
115regulation of cellular amine metabolic process (GO:0033238)2.90306084
116preassembly of GPI anchor in ER membrane (GO:0016254)2.90177414
117CTP metabolic process (GO:0046036)2.89561692
118CTP biosynthetic process (GO:0006241)2.89561692
119transcription from RNA polymerase I promoter (GO:0006360)2.89538949
120positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.89412951
121translational initiation (GO:0006413)2.86322240
122cellular component biogenesis (GO:0044085)2.86206720
123ribonucleoside triphosphate biosynthetic process (GO:0009201)2.84356415
124anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.82589081
125DNA ligation (GO:0006266)2.81452171
126nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.79702445
127L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.78031268
128deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.77912130
129UTP metabolic process (GO:0046051)2.77081047
130signal peptide processing (GO:0006465)2.76950802

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.60026601
2* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.51527493
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.23082662
4* GABP_17652178_ChIP-ChIP_JURKAT_Human3.92825285
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.83861655
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.66447600
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.22954549
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.16327357
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.06518377
10CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.86168504
11* ETS1_20019798_ChIP-Seq_JURKAT_Human2.67017606
12* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.64642238
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.59287622
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.49350659
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.29845870
16SRF_21415370_ChIP-Seq_HL-1_Mouse2.22249160
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.20568135
18E2F7_22180533_ChIP-Seq_HELA_Human2.13329796
19ELK1_19687146_ChIP-ChIP_HELA_Human2.12040134
20TAF15_26573619_Chip-Seq_HEK293_Human2.11288064
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.07339845
22ZNF274_21170338_ChIP-Seq_K562_Hela2.06986970
23* VDR_23849224_ChIP-Seq_CD4+_Human2.00093422
24VDR_22108803_ChIP-Seq_LS180_Human1.99891873
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.98441538
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.96700342
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89124170
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.82933509
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.82118919
30IRF1_19129219_ChIP-ChIP_H3396_Human1.82027120
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.79868631
32MYC_18358816_ChIP-ChIP_MESCs_Mouse1.77561906
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.77375510
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74567210
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.69814225
36DCP1A_22483619_ChIP-Seq_HELA_Human1.68427811
37FUS_26573619_Chip-Seq_HEK293_Human1.63465846
38GBX2_23144817_ChIP-Seq_PC3_Human1.57931547
39YY1_21170310_ChIP-Seq_MESCs_Mouse1.55336403
40* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53878911
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.53150626
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.52645824
43MYC_19030024_ChIP-ChIP_MESCs_Mouse1.49962353
44* FOXP3_21729870_ChIP-Seq_TREG_Human1.49517722
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45168786
46E2F1_18555785_ChIP-Seq_MESCs_Mouse1.42254499
47TTF2_22483619_ChIP-Seq_HELA_Human1.41446899
48POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39019843
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.35451513
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35301169
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35093237
52ELK1_22589737_ChIP-Seq_MCF10A_Human1.33800630
53EWS_26573619_Chip-Seq_HEK293_Human1.32553261
54POU5F1_16153702_ChIP-ChIP_HESCs_Human1.30062094
55HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.29506537
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.28775308
57MYC_19079543_ChIP-ChIP_MESCs_Mouse1.26422748
58CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.26336140
59ER_23166858_ChIP-Seq_MCF-7_Human1.26233009
60MYC_18940864_ChIP-ChIP_HL60_Human1.25283088
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24798089
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.22870602
63XRN2_22483619_ChIP-Seq_HELA_Human1.21235927
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.20456100
65ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.18377501
66PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16932933
67E2F4_17652178_ChIP-ChIP_JURKAT_Human1.15438957
68TP53_22573176_ChIP-Seq_HFKS_Human1.14086076
69SALL1_21062744_ChIP-ChIP_HESCs_Human1.12975683
70IGF1R_20145208_ChIP-Seq_DFB_Human1.12871876
71EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.11283247
72CBX2_27304074_Chip-Seq_ESCs_Mouse1.10306183
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.10270166
74IRF8_21731497_ChIP-ChIP_J774_Mouse1.09538070
75EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08668999
76EZH2_22144423_ChIP-Seq_EOC_Human1.08086697
77RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08005964
78P300_19829295_ChIP-Seq_ESCs_Human1.07716412
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06967681
80MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06698253
81SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06428954
82NANOG_16153702_ChIP-ChIP_HESCs_Human1.06190677
83STAT3_18555785_Chip-Seq_ESCs_Mouse1.05683669
84EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05523476
85MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.04950201
86E2F1_21310950_ChIP-Seq_MCF-7_Human1.04587132
87CTBP2_25329375_ChIP-Seq_LNCAP_Human1.02515433
88POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.01792421
89SOX2_16153702_ChIP-ChIP_HESCs_Human1.01271721
90P300_18555785_Chip-Seq_ESCs_Mouse1.00933005
91RUNX1_27457419_Chip-Seq_LIVER_Mouse1.00434874
92FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99299552
93TAL1_26923725_Chip-Seq_HPCs_Mouse0.97739038
94P53_22387025_ChIP-Seq_ESCs_Mouse0.97385455
95IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.97041335
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96955281
97RNF2_27304074_Chip-Seq_NSC_Mouse0.96883001
98* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95909805
99HTT_18923047_ChIP-ChIP_STHdh_Human0.95764336
100MYCN_18555785_ChIP-Seq_MESCs_Mouse0.95197951
101NANOG_18555785_Chip-Seq_ESCs_Mouse0.95185650
102* SOX17_20123909_ChIP-Seq_XEN_Mouse0.94101247
103CTBP1_25329375_ChIP-Seq_LNCAP_Human0.93560390
104GABP_19822575_ChIP-Seq_HepG2_Human0.93379987
105CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93155513
106NMYC_18555785_Chip-Seq_ESCs_Mouse0.93081676
107CMYC_18555785_Chip-Seq_ESCs_Mouse0.92217637
108PADI4_21655091_ChIP-ChIP_MCF-7_Human0.91930327
109SMAD1_18555785_Chip-Seq_ESCs_Mouse0.91786251
110SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91775597
111* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91605716
112SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.91540628
113SOX2_19829295_ChIP-Seq_ESCs_Human0.90813876
114NANOG_19829295_ChIP-Seq_ESCs_Human0.90813876
115FOXA1_25329375_ChIP-Seq_VCAP_Human0.90705333
116FOXA1_27270436_Chip-Seq_PROSTATE_Human0.90705333
117E2F1_18555785_Chip-Seq_ESCs_Mouse0.90221283
118CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.89557174
119NELFA_20434984_ChIP-Seq_ESCs_Mouse0.89045596
120SOX2_18555785_Chip-Seq_ESCs_Mouse0.88056942
121ERG_20887958_ChIP-Seq_HPC-7_Mouse0.87440040
122KLF4_18555785_Chip-Seq_ESCs_Mouse0.86820587
123AR_20517297_ChIP-Seq_VCAP_Human0.86264539
124CRX_20693478_ChIP-Seq_RETINA_Mouse0.86125272
125ZFX_18555785_Chip-Seq_ESCs_Mouse0.85583603
126PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.84692541
127OCT4_18555785_Chip-Seq_ESCs_Mouse0.83776651
128SOX2_18555785_ChIP-Seq_MESCs_Mouse0.81761045
129BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.81655973
130KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.79781179
131GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.76463427
132KDM5A_27292631_Chip-Seq_BREAST_Human0.75712478
133E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.75219064

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.39028678
2MP0001529_abnormal_vocalization3.75869621
3MP0003136_yellow_coat_color3.57527940
4MP0003880_abnormal_central_pattern3.53497413
5MP0001905_abnormal_dopamine_level3.09009597
6MP0001188_hyperpigmentation2.81028124
7MP0005409_darkened_coat_color2.58414441
8MP0002837_dystrophic_cardiac_calcinosis2.54576420
9MP0004381_abnormal_hair_follicle2.41030888
10MP0006292_abnormal_olfactory_placode2.39323230
11MP0005171_absent_coat_pigmentation2.34336303
12MP0009697_abnormal_copulation2.08040258
13MP0001986_abnormal_taste_sensitivity1.94989933
14MP0006276_abnormal_autonomic_nervous1.92572385
15MP0000372_irregular_coat_pigmentation1.92137278
16MP0005379_endocrine/exocrine_gland_phen1.90661284
17MP0002277_abnormal_respiratory_mucosa1.90451012
18MP0000920_abnormal_myelination1.90293325
19MP0004147_increased_porphyrin_level1.82173435
20MP0003718_maternal_effect1.80457689
21MP0002638_abnormal_pupillary_reflex1.77404497
22MP0000566_synostosis1.77396997
23MP0003186_abnormal_redox_activity1.76346687
24MP0004142_abnormal_muscle_tone1.73759123
25MP0008789_abnormal_olfactory_epithelium1.72465087
26MP0005084_abnormal_gallbladder_morpholo1.72387462
27MP0002132_abnormal_respiratory_system1.71104135
28MP0002163_abnormal_gland_morphology1.70762962
29MP0003077_abnormal_cell_cycle1.68199131
30MP0002148_abnormal_hypersensitivity_rea1.67358091
31MP0004742_abnormal_vestibular_system1.67109520
32MP0003724_increased_susceptibility_to1.66984545
33MP0002938_white_spotting1.65016667
34MP0001293_anophthalmia1.62808765
35MP0003111_abnormal_nucleus_morphology1.60026044
36MP0002234_abnormal_pharynx_morphology1.55279790
37MP0001485_abnormal_pinna_reflex1.48308408
38MP0005451_abnormal_body_composition1.47302976
39MP0008058_abnormal_DNA_repair1.45783360
40MP0002736_abnormal_nociception_after1.40714259
41MP0005408_hypopigmentation1.40112683
42MP0003950_abnormal_plasma_membrane1.38734970
43MP0008875_abnormal_xenobiotic_pharmacok1.38110623
44MP0000015_abnormal_ear_pigmentation1.37312335
45MP0008007_abnormal_cellular_replicative1.36722389
46MP0008260_abnormal_autophagy1.34755085
47MP0008932_abnormal_embryonic_tissue1.34028406
48MP0002102_abnormal_ear_morphology1.33832625
49MP0002272_abnormal_nervous_system1.31046148
50MP0008872_abnormal_physiological_respon1.30030352
51MP0001968_abnormal_touch/_nociception1.25402312
52MP0003941_abnormal_skin_development1.25307546
53MP0002160_abnormal_reproductive_system1.25218032
54MP0004145_abnormal_muscle_electrophysio1.21725149
55MP0006036_abnormal_mitochondrial_physio1.21435448
56MP0005423_abnormal_somatic_nervous1.20886231
57MP0009785_altered_susceptibility_to1.20838587
58MP0002735_abnormal_chemical_nociception1.15755926
59MP0001440_abnormal_grooming_behavior1.15731642
60MP0000631_abnormal_neuroendocrine_gland1.15615206
61MP0010386_abnormal_urinary_bladder1.15434709
62MP0005394_taste/olfaction_phenotype1.14734849
63MP0005499_abnormal_olfactory_system1.14734849
64MP0005075_abnormal_melanosome_morpholog1.14365965
65MP0003806_abnormal_nucleotide_metabolis1.13915472
66MP0003786_premature_aging1.13653999
67MP0001486_abnormal_startle_reflex1.13372688
68MP0001727_abnormal_embryo_implantation1.13190779
69MP0002876_abnormal_thyroid_physiology1.13027011
70MP0002210_abnormal_sex_determination1.12065173
71MP0005174_abnormal_tail_pigmentation1.11800782
72MP0008057_abnormal_DNA_replication1.08981684
73MP0005389_reproductive_system_phenotype1.06935584
74MP0009745_abnormal_behavioral_response1.06645249
75MP0004133_heterotaxia1.05641587
76MP0004215_abnormal_myocardial_fiber1.03891140
77MP0003567_abnormal_fetal_cardiomyocyte1.03104451
78MP0001929_abnormal_gametogenesis1.01383977
79MP0006035_abnormal_mitochondrial_morpho1.00734542
80MP0005645_abnormal_hypothalamus_physiol1.00428929
81MP0005551_abnormal_eye_electrophysiolog0.99940010
82MP0002734_abnormal_mechanical_nocicepti0.98894104
83MP0001963_abnormal_hearing_physiology0.98760147
84MP0003121_genomic_imprinting0.98653107
85MP0003693_abnormal_embryo_hatching0.98406754
86MP0000026_abnormal_inner_ear0.97723055
87MP0000049_abnormal_middle_ear0.97531734
88MP0005410_abnormal_fertilization0.96955994
89MP0003011_delayed_dark_adaptation0.96813923
90MP0005332_abnormal_amino_acid0.95867744
91MP0002064_seizures0.94855383
92MP0000653_abnormal_sex_gland0.94517932
93MP0001145_abnormal_male_reproductive0.94100893
94MP0001764_abnormal_homeostasis0.93437782
95MP0005646_abnormal_pituitary_gland0.91925788
96MP0005671_abnormal_response_to0.91814738
97MP0004957_abnormal_blastocyst_morpholog0.91414132
98MP0002090_abnormal_vision0.91299026
99MP0003646_muscle_fatigue0.91150137
100MP0005253_abnormal_eye_physiology0.89509397
101MP0003938_abnormal_ear_development0.88139834
102MP0003137_abnormal_impulse_conducting0.87645233
103MP0006072_abnormal_retinal_apoptosis0.87196621
104MP0009046_muscle_twitch0.86605816
105MP0008995_early_reproductive_senescence0.86244312
106MP0002751_abnormal_autonomic_nervous0.85655100
107MP0002572_abnormal_emotion/affect_behav0.85488545
108MP0003937_abnormal_limbs/digits/tail_de0.85383262
109MP0001984_abnormal_olfaction0.85180902
110MP0005367_renal/urinary_system_phenotyp0.83930048
111MP0000516_abnormal_urinary_system0.83930048
112MP0002067_abnormal_sensory_capabilities0.83768719
113MP0002095_abnormal_skin_pigmentation0.83585195
114MP0003890_abnormal_embryonic-extraembry0.82770135
115MP0001835_abnormal_antigen_presentation0.82479615
116MP0001542_abnormal_bone_strength0.81626745
117MP0005000_abnormal_immune_tolerance0.80876965
118MP0003315_abnormal_perineum_morphology0.79934127
119MP0004270_analgesia0.78529078
120MP0001970_abnormal_pain_threshold0.78230856
121MP0001919_abnormal_reproductive_system0.78105252
122MP0003698_abnormal_male_reproductive0.77875974
123MP0001286_abnormal_eye_development0.77477803
124MP0002752_abnormal_somatic_nervous0.77369634
125MP0008877_abnormal_DNA_methylation0.77054879
126MP0005195_abnormal_posterior_eye0.76959544
127MP0005025_abnormal_response_to0.76742755
128MP0005391_vision/eye_phenotype0.76636581
129MP0001501_abnormal_sleep_pattern0.76627848
130MP0000778_abnormal_nervous_system0.75200643
131MP0000647_abnormal_sebaceous_gland0.74367318
132MP0002229_neurodegeneration0.73266490
133MP0005636_abnormal_mineral_homeostasis0.73159240
134MP0006082_CNS_inflammation0.71612924
135MP0000358_abnormal_cell_content/0.71498084
136MP0010094_abnormal_chromosome_stability0.71436063
137MP0003787_abnormal_imprinting0.71408950
138MP0005386_behavior/neurological_phenoty0.71255654
139MP0004924_abnormal_behavior0.71255654
140MP0002233_abnormal_nose_morphology0.71099413
141MP0001853_heart_inflammation0.70299484
142MP0001664_abnormal_digestion0.69602718
143MP0002419_abnormal_innate_immunity0.68725989
144MP0003119_abnormal_digestive_system0.68052526
145MP0003195_calcinosis0.66847393
146MP0000762_abnormal_tongue_morphology0.64785036

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.50239911
2Increased hepatocellular lipid droplets (HP:0006565)5.08895516
3Mitochondrial inheritance (HP:0001427)5.08694168
4Renal Fanconi syndrome (HP:0001994)4.92429605
5Abnormal mitochondria in muscle tissue (HP:0008316)4.73419586
6Progressive macrocephaly (HP:0004481)4.61542226
73-Methylglutaconic aciduria (HP:0003535)4.56296767
8Lipid accumulation in hepatocytes (HP:0006561)4.34038774
9Acute encephalopathy (HP:0006846)4.31385857
10Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.27676511
11Parakeratosis (HP:0001036)4.27047492
12Increased CSF lactate (HP:0002490)4.25486145
13Hepatocellular necrosis (HP:0001404)4.04507822
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.01050645
15Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.85686819
16Hepatic necrosis (HP:0002605)3.46428433
17Exertional dyspnea (HP:0002875)3.45389909
18Abnormality of renal resorption (HP:0011038)3.40944443
19Abnormality of cells of the erythroid lineage (HP:0012130)3.39255421
20Increased intramyocellular lipid droplets (HP:0012240)3.24222261
21Abnormal number of erythroid precursors (HP:0012131)3.17392015
22Increased serum pyruvate (HP:0003542)3.12711042
23Abnormality of glycolysis (HP:0004366)3.12711042
24Reticulocytopenia (HP:0001896)3.08037276
25Optic disc pallor (HP:0000543)3.06779334
26Increased serum lactate (HP:0002151)3.02087055
27Leukodystrophy (HP:0002415)3.01801010
28Congenital ichthyosiform erythroderma (HP:0007431)2.97122055
29Decreased activity of mitochondrial respiratory chain (HP:0008972)2.92437339
30Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.92437339
31Cerebral edema (HP:0002181)2.90782531
32Exercise intolerance (HP:0003546)2.88931720
33Respiratory difficulties (HP:0002880)2.85634445
34Respiratory failure (HP:0002878)2.83653612
35Macrocytic anemia (HP:0001972)2.74964667
36Colon cancer (HP:0003003)2.74694900
37Pancreatic cysts (HP:0001737)2.74367647
38Pancreatic fibrosis (HP:0100732)2.69363200
39Lactic acidosis (HP:0003128)2.69042172
40Abnormality of midbrain morphology (HP:0002418)2.60191725
41Molar tooth sign on MRI (HP:0002419)2.60191725
42Abnormality of secondary sexual hair (HP:0009888)2.59259355
43Abnormality of the axillary hair (HP:0100134)2.59259355
44Increased muscle lipid content (HP:0009058)2.48686130
45Microvesicular hepatic steatosis (HP:0001414)2.48489377
46Lethargy (HP:0001254)2.44983985
47Cerebral hypomyelination (HP:0006808)2.41204079
48Congenital stationary night blindness (HP:0007642)2.38738403
49True hermaphroditism (HP:0010459)2.35586512
50Pallor (HP:0000980)2.34688833
51Aplasia/Hypoplasia of the sacrum (HP:0008517)2.34019128
52Amniotic constriction ring (HP:0009775)2.31075662
53Abnormality of placental membranes (HP:0011409)2.31075662
54Glycosuria (HP:0003076)2.29554417
55Abnormality of urine glucose concentration (HP:0011016)2.29554417
56Hypothermia (HP:0002045)2.27148832
57Generalized aminoaciduria (HP:0002909)2.24378523
58Birth length less than 3rd percentile (HP:0003561)2.19095347
59Duplicated collecting system (HP:0000081)2.18213746
60Meckel diverticulum (HP:0002245)2.17838371
61Hypoplasia of the fovea (HP:0007750)2.15307177
62Aplasia/Hypoplasia of the fovea (HP:0008060)2.15307177
63Abnormal rod and cone electroretinograms (HP:0008323)2.13889390
64Hyperphosphaturia (HP:0003109)2.12091313
65Hyperalaninemia (HP:0003348)2.11586967
66Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.11586967
67Abnormality of alanine metabolism (HP:0010916)2.11586967
68Renal tubular dysfunction (HP:0000124)2.11209735
69Abnormality of methionine metabolism (HP:0010901)2.10354736
70Abnormality of the labia minora (HP:0012880)2.09221143
71Abnormality of the ileum (HP:0001549)2.08426253
72Abnormal ciliary motility (HP:0012262)2.07128862
73Absent/shortened dynein arms (HP:0200106)2.06632636
74Dynein arm defect of respiratory motile cilia (HP:0012255)2.06632636
75Aplasia/Hypoplasia of the uvula (HP:0010293)2.06088652
76Abnormality of aspartate family amino acid metabolism (HP:0010899)2.04466857
77Sensory axonal neuropathy (HP:0003390)2.04151213
78Type I transferrin isoform profile (HP:0003642)2.03698142
79Abnormal respiratory motile cilium morphology (HP:0005938)2.03467694
80Abnormal respiratory epithelium morphology (HP:0012253)2.03467694
81Degeneration of anterior horn cells (HP:0002398)2.02050301
82Abnormality of the anterior horn cell (HP:0006802)2.02050301
83Methylmalonic acidemia (HP:0002912)2.01367236
84Nephronophthisis (HP:0000090)2.00769177
85Pendular nystagmus (HP:0012043)1.99514834
86Oral leukoplakia (HP:0002745)1.98271304
87Abnormality of serum amino acid levels (HP:0003112)1.97826492
88Hyperglycinemia (HP:0002154)1.97218377
89Hypoplasia of the pons (HP:0012110)1.95752750
90Sclerocornea (HP:0000647)1.94893999
91Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.93787327
92Abnormal protein N-linked glycosylation (HP:0012347)1.93787327
93Abnormal protein glycosylation (HP:0012346)1.93787327
94Abnormal glycosylation (HP:0012345)1.93787327
95Abnormality of the renal collecting system (HP:0004742)1.93650530
96Patchy hypopigmentation of hair (HP:0011365)1.93557678
97Abnormality of the fovea (HP:0000493)1.93216940
98Abnormal urine phosphate concentration (HP:0012599)1.92789977
99Hepatosplenomegaly (HP:0001433)1.91369042
100X-linked dominant inheritance (HP:0001423)1.91289720
101Chromosomal breakage induced by crosslinking agents (HP:0003221)1.89577614
102Aplasia/hypoplasia of the uterus (HP:0008684)1.88748633
103Medial flaring of the eyebrow (HP:0010747)1.88498403
104Renal cortical cysts (HP:0000803)1.88471184
105Abnormality of the pons (HP:0007361)1.87339490
106Abnormality of chromosome stability (HP:0003220)1.84788943
107Absent thumb (HP:0009777)1.80473671
108Chromsome breakage (HP:0040012)1.79789498
109Breast hypoplasia (HP:0003187)1.77921590
110Retinal dysplasia (HP:0007973)1.76314856
111CNS demyelination (HP:0007305)1.73704419
112Abnormality of the renal cortex (HP:0011035)1.73674365
113Reduced antithrombin III activity (HP:0001976)1.73673942
114Abnormality of macular pigmentation (HP:0008002)1.73278655
115Congenital sensorineural hearing impairment (HP:0008527)1.72520003
116Erythroderma (HP:0001019)1.70720275
117Congenital primary aphakia (HP:0007707)1.70475886
118Congenital, generalized hypertrichosis (HP:0004540)1.70084617
119White forelock (HP:0002211)1.70047065
120Absent rod-and cone-mediated responses on ERG (HP:0007688)1.68957794
121Stenosis of the external auditory canal (HP:0000402)1.68385081
122Megaloblastic anemia (HP:0001889)1.68216760
123Dicarboxylic aciduria (HP:0003215)1.66995375
124Abnormality of dicarboxylic acid metabolism (HP:0010995)1.66995375
125Abnormality of vitamin B metabolism (HP:0004340)1.66816379
126Degeneration of the lateral corticospinal tracts (HP:0002314)1.66530515
127Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.66530515
128Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.66143376
129Abnormality of the septum pellucidum (HP:0007375)1.66135084
130Abnormal pupillary function (HP:0007686)1.64638042
131Pancytopenia (HP:0001876)1.61887396
132Abnormal respiratory motile cilium physiology (HP:0012261)1.56483792
133Aplastic anemia (HP:0001915)1.54419893
134Abnormality of the preputium (HP:0100587)1.54392792
135Abnormality of the heme biosynthetic pathway (HP:0010472)1.53340927
136Delusions (HP:0000746)1.51684534
137Blindness (HP:0000618)1.51607618
138Abnormal hair whorl (HP:0010721)1.50673880
139Septo-optic dysplasia (HP:0100842)1.50364080
140Hypoplasia of the uterus (HP:0000013)1.48990364
141CNS hypomyelination (HP:0003429)1.48862288
142Conical tooth (HP:0000698)1.48689135
143Prolonged neonatal jaundice (HP:0006579)1.48682370
144Nephrogenic diabetes insipidus (HP:0009806)1.48629375
145Asplenia (HP:0001746)1.48582703
146Methylmalonic aciduria (HP:0012120)1.48479716
147Absent septum pellucidum (HP:0001331)1.48020437
148Triphalangeal thumb (HP:0001199)1.47269947

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.28375797
2STK163.86667209
3PBK3.29075235
4CASK2.79189902
5STK392.70261829
6NME22.44491352
7NME12.37630721
8BUB12.34969026
9CDC72.34583213
10MST42.27066014
11WNK32.16213711
12SRPK12.04704057
13FRK2.04413680
14TRIM282.02119508
15VRK11.99474673
16TNIK1.97070378
17OXSR11.94250828
18MAP4K21.92102253
19EIF2AK11.88123490
20TAF11.87841253
21NEK11.85781198
22BMPR1B1.83065245
23GRK71.82028105
24BCR1.79962296
25EIF2AK31.72617420
26MAP3K121.67951525
27TLK11.66698228
28MUSK1.57624460
29MAPKAPK51.52584629
30ADRBK21.44228793
31PNCK1.42006556
32MKNK11.36341088
33TTK1.36006301
34IRAK41.35777900
35BMPR21.33580153
36ZAK1.32068876
37EIF2AK21.31046895
38WEE11.30807910
39DYRK21.28253346
40ARAF1.25781508
41TXK1.22617690
42PLK41.21100960
43BLK1.20369851
44BRSK21.20261748
45GRK11.17548319
46PIM21.17443715
47NEK61.16184403
48IRAK31.13067107
49BCKDK1.12971563
50CLK11.09906042
51CSNK1G31.09640449
52PINK11.09349277
53PKN11.07108892
54CDK191.06662916
55MYLK1.05653387
56INSRR1.02665704
57ERBB30.97183646
58FGR0.92759918
59YES10.91400560
60PDK20.89594332
61MKNK20.88558860
62RPS6KA50.88231326
63MAP3K40.87226152
64LIMK10.86859995
65CAMK2B0.84253387
66GRK50.84088182
67WNK40.80790753
68AURKB0.80096535
69ABL20.79895801
70MAP2K70.78817371
71ATR0.76452812
72RIPK40.75558700
73DYRK30.73721009
74BRAF0.73065363
75CSNK1G10.72953821
76ACVR1B0.72829125
77OBSCN0.72244997
78IRAK20.70630952
79PIK3CG0.65390366
80MAP3K140.64350184
81TEC0.62292712
82MAPK130.62072843
83CSNK2A10.61223487
84CSNK1A1L0.60953134
85IRAK10.60866562
86DAPK10.60493475
87PASK0.59812632
88STK38L0.59132948
89PLK20.58685005
90CDK80.57693499
91CAMK2D0.57648683
92PRKCG0.56899310
93PLK30.56774391
94AURKA0.56644797
95LYN0.55365429
96PRKCE0.54869944
97CAMK2A0.54849309
98CDK30.54569412
99BRSK10.53834316
100CSNK2A20.51760991
101ADRBK10.51045690
102CAMK2G0.49609756
103CSNK1G20.49325224
104MARK10.48436083
105UHMK10.47830234
106NEK20.47733115
107AKT30.47071561
108TESK20.46304070
109CCNB10.46187749
110PRKCQ0.45788810
111IKBKB0.45721409
112ATM0.45690482
113EPHA40.44776289
114PHKG20.44407751
115PHKG10.44407751
116TSSK60.43531915
117DAPK30.43063647
118CSNK1A10.41959840
119TIE10.41490158
120PIK3CA0.40297356
121STK40.39920243
122TRPM70.39662684
123KDR0.39616721
124PLK10.39582284
125NUAK10.39558406
126SIK30.39411844
127STK30.39411574
128FES0.38912194
129CSNK1E0.38714295
130ROCK20.38336093
131SYK0.37638426
132PAK30.37550327
133CHEK20.36869641
134TGFBR10.36656111
135PRKACA0.36237207
136PAK40.36090916
137TAOK30.32423147
138ILK0.32096680

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.02328684
2* Ribosome_Homo sapiens_hsa030104.36153846
3Parkinsons disease_Homo sapiens_hsa050124.13349438
4Proteasome_Homo sapiens_hsa030504.11518295
5Protein export_Homo sapiens_hsa030603.31249973
6RNA polymerase_Homo sapiens_hsa030203.29334466
7Alzheimers disease_Homo sapiens_hsa050103.12515138
8Huntingtons disease_Homo sapiens_hsa050163.05587928
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.56199152
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.23871956
11Fatty acid elongation_Homo sapiens_hsa000621.90422169
12Pyrimidine metabolism_Homo sapiens_hsa002401.86195241
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.82092280
14Homologous recombination_Homo sapiens_hsa034401.74783425
15Steroid biosynthesis_Homo sapiens_hsa001001.71057778
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.64486962
17Basal transcription factors_Homo sapiens_hsa030221.59888261
18Nucleotide excision repair_Homo sapiens_hsa034201.59099866
19Spliceosome_Homo sapiens_hsa030401.51715959
20Collecting duct acid secretion_Homo sapiens_hsa049661.51712722
21Cardiac muscle contraction_Homo sapiens_hsa042601.51172586
22Mismatch repair_Homo sapiens_hsa034301.48828110
23DNA replication_Homo sapiens_hsa030301.48713880
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45655687
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.44823761
26Propanoate metabolism_Homo sapiens_hsa006401.44460563
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.38093397
28Non-homologous end-joining_Homo sapiens_hsa034501.29137087
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.27274768
30Fanconi anemia pathway_Homo sapiens_hsa034601.25786292
31Ether lipid metabolism_Homo sapiens_hsa005651.21789956
32Purine metabolism_Homo sapiens_hsa002301.20621875
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19587240
34Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.14143871
35Rheumatoid arthritis_Homo sapiens_hsa053231.13688089
36Graft-versus-host disease_Homo sapiens_hsa053321.06230929
37Arachidonic acid metabolism_Homo sapiens_hsa005901.06227351
38Sulfur metabolism_Homo sapiens_hsa009201.05321189
39Sphingolipid metabolism_Homo sapiens_hsa006001.04061050
40Pyruvate metabolism_Homo sapiens_hsa006201.03117322
41Phototransduction_Homo sapiens_hsa047441.01984534
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99725696
43Butanoate metabolism_Homo sapiens_hsa006500.96901914
44RNA degradation_Homo sapiens_hsa030180.96791076
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.96245735
46Allograft rejection_Homo sapiens_hsa053300.91567800
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91514830
48Asthma_Homo sapiens_hsa053100.90904865
49Vibrio cholerae infection_Homo sapiens_hsa051100.88411845
50Glutathione metabolism_Homo sapiens_hsa004800.88309627
51Linoleic acid metabolism_Homo sapiens_hsa005910.88049677
52Base excision repair_Homo sapiens_hsa034100.87918565
53Autoimmune thyroid disease_Homo sapiens_hsa053200.87189682
54Histidine metabolism_Homo sapiens_hsa003400.84467219
55Metabolic pathways_Homo sapiens_hsa011000.80311325
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.77659100
57Selenocompound metabolism_Homo sapiens_hsa004500.76362265
58Tryptophan metabolism_Homo sapiens_hsa003800.69788470
59Serotonergic synapse_Homo sapiens_hsa047260.68326093
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68315561
61Folate biosynthesis_Homo sapiens_hsa007900.65064915
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63944007
63Nicotine addiction_Homo sapiens_hsa050330.63605040
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63192210
65Tyrosine metabolism_Homo sapiens_hsa003500.62958425
66RNA transport_Homo sapiens_hsa030130.62901687
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61949063
68Phagosome_Homo sapiens_hsa041450.61367611
69Caffeine metabolism_Homo sapiens_hsa002320.60184726
70Sulfur relay system_Homo sapiens_hsa041220.59369495
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57272475
72Phenylalanine metabolism_Homo sapiens_hsa003600.56721154
73Vitamin B6 metabolism_Homo sapiens_hsa007500.56066081
74Nitrogen metabolism_Homo sapiens_hsa009100.54908854
75beta-Alanine metabolism_Homo sapiens_hsa004100.54569236
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53995500
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52939722
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52135789
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51150376
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49198788
81Arginine and proline metabolism_Homo sapiens_hsa003300.46886020
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.43556275
83Systemic lupus erythematosus_Homo sapiens_hsa053220.43168242
84Intestinal immune network for IgA production_Homo sapiens_hsa046720.42785395
85Chemical carcinogenesis_Homo sapiens_hsa052040.42136865
86p53 signaling pathway_Homo sapiens_hsa041150.40654281
87Epstein-Barr virus infection_Homo sapiens_hsa051690.40540783
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40446173
89Oocyte meiosis_Homo sapiens_hsa041140.40140129
90Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.40058274
91mRNA surveillance pathway_Homo sapiens_hsa030150.39362874
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38864033
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.38760914
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38508095
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37830936
96Fatty acid degradation_Homo sapiens_hsa000710.36368256
97Regulation of autophagy_Homo sapiens_hsa041400.36109341
98Hematopoietic cell lineage_Homo sapiens_hsa046400.35799843
99Primary immunodeficiency_Homo sapiens_hsa053400.35150294
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33092101
101Vitamin digestion and absorption_Homo sapiens_hsa049770.32088309
102Malaria_Homo sapiens_hsa051440.32047001
103Olfactory transduction_Homo sapiens_hsa047400.31895824
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31286407
105Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.29384526
106Peroxisome_Homo sapiens_hsa041460.29012034
107African trypanosomiasis_Homo sapiens_hsa051430.28515762
108Type I diabetes mellitus_Homo sapiens_hsa049400.28300664
109Carbon metabolism_Homo sapiens_hsa012000.27990466
110Other glycan degradation_Homo sapiens_hsa005110.27609809
111Retinol metabolism_Homo sapiens_hsa008300.27357168
112Fatty acid metabolism_Homo sapiens_hsa012120.25730887
113NOD-like receptor signaling pathway_Homo sapiens_hsa046210.23769872
114Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.23476625
115Taste transduction_Homo sapiens_hsa047420.22040428
1162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.20399673
117Fat digestion and absorption_Homo sapiens_hsa049750.20253359
118Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.18700386
119Alcoholism_Homo sapiens_hsa050340.17580429
120Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.17564909
121Cell cycle_Homo sapiens_hsa041100.17353547
122NF-kappa B signaling pathway_Homo sapiens_hsa040640.17109670
123Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.16312232
124One carbon pool by folate_Homo sapiens_hsa006700.15098176
125Pertussis_Homo sapiens_hsa051330.14746072
126Drug metabolism - other enzymes_Homo sapiens_hsa009830.11775396
127Mineral absorption_Homo sapiens_hsa049780.11276747
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.09382534

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