MRPS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S2 family. Alternatively spliced transcript variants have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)7.30789974
2doxorubicin metabolic process (GO:0044598)7.30789974
3daunorubicin metabolic process (GO:0044597)7.30789974
4protein localization to kinetochore (GO:0034501)5.81237778
5regulation of nuclear cell cycle DNA replication (GO:0033262)5.21966949
6aminoglycoside antibiotic metabolic process (GO:0030647)4.87222363
7DNA replication checkpoint (GO:0000076)4.76008853
8DNA replication-dependent nucleosome organization (GO:0034723)4.68704867
9DNA replication-dependent nucleosome assembly (GO:0006335)4.68704867
10rRNA transcription (GO:0009303)4.47684703
11formation of translation preinitiation complex (GO:0001731)4.42308107
12mitotic sister chromatid segregation (GO:0000070)4.41985124
13protein localization to chromosome, centromeric region (GO:0071459)4.41625550
14negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.38816351
15negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.37816000
16regulation of telomere maintenance via telomerase (GO:0032210)4.36710238
17maturation of SSU-rRNA (GO:0030490)4.32216391
18DNA unwinding involved in DNA replication (GO:0006268)4.27042544
19regulation of mammary gland epithelial cell proliferation (GO:0033599)4.26469467
20regulation of mitochondrial translation (GO:0070129)4.23037520
21ribosome biogenesis (GO:0042254)4.21150592
22histone H4-K12 acetylation (GO:0043983)4.20501152
23rRNA modification (GO:0000154)4.18990034
24cullin deneddylation (GO:0010388)4.15355284
25negative regulation of cell cycle G2/M phase transition (GO:1902750)4.15136293
26DNA replication initiation (GO:0006270)4.11772637
27ribosomal small subunit assembly (GO:0000028)4.08968316
28nucleobase-containing small molecule interconversion (GO:0015949)4.08962794
29viral transcription (GO:0019083)4.08128473
30rRNA methylation (GO:0031167)4.07565296
31somite rostral/caudal axis specification (GO:0032525)4.00032937
32negative regulation of telomerase activity (GO:0051974)3.98940922
33pseudouridine synthesis (GO:0001522)3.98600960
34establishment of integrated proviral latency (GO:0075713)3.97589543
35maintenance of protein location in nucleus (GO:0051457)3.97538697
36heterochromatin organization (GO:0070828)3.96442096
37negative regulation of epidermis development (GO:0045683)3.93255459
38translational termination (GO:0006415)3.92081504
39protein deneddylation (GO:0000338)3.91062587
40histone H4-K5 acetylation (GO:0043981)3.89374147
41histone H4-K8 acetylation (GO:0043982)3.89374147
42deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.86793104
43protein maturation by protein folding (GO:0022417)3.84831377
44peptidyl-arginine omega-N-methylation (GO:0035247)3.84754147
45negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.84557949
46ribosomal large subunit biogenesis (GO:0042273)3.83202107
47folic acid-containing compound biosynthetic process (GO:0009396)3.82564050
48proline biosynthetic process (GO:0006561)3.81286331
49nuclear pore organization (GO:0006999)3.78425114
50regulation of translational fidelity (GO:0006450)3.77594287
51nuclear pore complex assembly (GO:0051292)3.76855386
52pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.76494525
53ribosome assembly (GO:0042255)3.75913808
54positive regulation of DNA-dependent DNA replication (GO:2000105)3.75538135
55regulation of translation in response to stress (GO:0043555)3.75519947
56pteridine-containing compound biosynthetic process (GO:0042559)3.71490184
57sister chromatid segregation (GO:0000819)3.70756170
58translational elongation (GO:0006414)3.70187930
59pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.67910878
60L-serine metabolic process (GO:0006563)3.62637346
61guanosine-containing compound biosynthetic process (GO:1901070)3.55333581
62mitotic chromosome condensation (GO:0007076)3.54855423
63pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.54044199
64nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.53766670
65SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.50671139
66transcription from mitochondrial promoter (GO:0006390)3.49837297
67DNA duplex unwinding (GO:0032508)3.49224895
68DNA geometric change (GO:0032392)3.46655241
69translational initiation (GO:0006413)3.46122481
70quinone metabolic process (GO:1901661)3.45869970
71regulation of response to osmotic stress (GO:0047484)3.45639098
72pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.42459852
73protein targeting to ER (GO:0045047)3.41186473
74nucleobase biosynthetic process (GO:0046112)3.40908323
75cotranslational protein targeting to membrane (GO:0006613)3.40444482
76muscle organ morphogenesis (GO:0048644)3.38906932
77negative regulation of telomere maintenance (GO:0032205)3.38069426
78UTP biosynthetic process (GO:0006228)3.37976898
79DNA strand elongation involved in DNA replication (GO:0006271)3.36862633
80mitotic nuclear envelope disassembly (GO:0007077)3.36699725
81pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.32046550
82IMP biosynthetic process (GO:0006188)3.31779523
83protein targeting to mitochondrion (GO:0006626)3.30216290
84telomere maintenance via recombination (GO:0000722)3.30064341
85establishment of viral latency (GO:0019043)3.29891309
86viral life cycle (GO:0019058)3.28758836
87CTP biosynthetic process (GO:0006241)3.28100689
88CTP metabolic process (GO:0046036)3.28100689
89ribonucleoprotein complex biogenesis (GO:0022613)3.27952320
90notochord development (GO:0030903)3.27754797
91proteasome assembly (GO:0043248)3.26896990
92chromatin assembly (GO:0031497)3.26460545
93negative regulation of mRNA processing (GO:0050686)3.25973860
94protein localization to endoplasmic reticulum (GO:0070972)3.25602792
95cellular component biogenesis (GO:0044085)3.25552664
96establishment of protein localization to endoplasmic reticulum (GO:0072599)3.25536208
97rRNA processing (GO:0006364)3.22869158
98spliceosomal snRNP assembly (GO:0000387)3.22203024
99chaperone-mediated protein transport (GO:0072321)3.20398739
100purine nucleobase biosynthetic process (GO:0009113)3.19515194
101DNA strand elongation (GO:0022616)3.18906517
102peptidyl-arginine methylation (GO:0018216)3.18448422
103peptidyl-arginine N-methylation (GO:0035246)3.18448422
104regulation of apoptotic process involved in morphogenesis (GO:1902337)3.18404682
105oxidative phosphorylation (GO:0006119)3.18366254
106mitochondrial DNA replication (GO:0006264)3.17775448
107DNA damage response, detection of DNA damage (GO:0042769)3.17294452
108negative regulation of RNA splicing (GO:0033119)3.17089964
109pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.16252096
110cellular protein complex disassembly (GO:0043624)3.14169346
111* translation (GO:0006412)3.13981660
112spliceosomal tri-snRNP complex assembly (GO:0000244)3.13806628
113regulation of gene silencing by RNA (GO:0060966)3.11672538
114regulation of posttranscriptional gene silencing (GO:0060147)3.11672538
115regulation of gene silencing by miRNA (GO:0060964)3.11672538
116folic acid metabolic process (GO:0046655)3.10644821
117coenzyme catabolic process (GO:0009109)3.09626249
118UTP metabolic process (GO:0046051)3.09270609
119negative regulation of epidermal cell differentiation (GO:0045605)3.08536496
120regulation of MHC class I biosynthetic process (GO:0045343)3.06702746
121nuclear envelope disassembly (GO:0051081)3.06335010
122membrane disassembly (GO:0030397)3.06335010
123telomere maintenance via semi-conservative replication (GO:0032201)3.05535359
124primitive streak formation (GO:0090009)3.04548733
125protein complex localization (GO:0031503)3.02666996
126rRNA metabolic process (GO:0016072)3.01879729
127negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.01366427
128pre-miRNA processing (GO:0031054)3.00740752
129GTP biosynthetic process (GO:0006183)2.99884649
130nucleoside transmembrane transport (GO:1901642)2.99763718
131tRNA aminoacylation for protein translation (GO:0006418)2.99062702
132base-excision repair (GO:0006284)2.98996660
133establishment of protein localization to mitochondrion (GO:0072655)2.98808916
134protein complex disassembly (GO:0043241)2.98527153
135cytidine catabolic process (GO:0006216)2.92399484
136cytidine deamination (GO:0009972)2.92399484
137cytidine metabolic process (GO:0046087)2.92399484
138mitochondrial DNA metabolic process (GO:0032042)2.91013429
139somatic diversification of immune receptors via somatic mutation (GO:0002566)2.90576790
140somatic hypermutation of immunoglobulin genes (GO:0016446)2.90576790
141negative regulation of mRNA metabolic process (GO:1903312)2.90138894
142mitotic metaphase plate congression (GO:0007080)2.89499883
143viral mRNA export from host cell nucleus (GO:0046784)2.89311617
144anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.88328458
145tRNA aminoacylation (GO:0043039)2.87314047
146amino acid activation (GO:0043038)2.87314047
147negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.86095690
148negative regulation of ligase activity (GO:0051352)2.86095690
149IMP metabolic process (GO:0046040)2.85112529
150mitotic nuclear envelope reassembly (GO:0007084)2.84999582
151nuclear envelope reassembly (GO:0031468)2.84999582
152macromolecular complex disassembly (GO:0032984)2.83897233
153regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.83828791
154GDP-mannose metabolic process (GO:0019673)2.83068796
155regulation of translational termination (GO:0006449)2.82798216
156histone arginine methylation (GO:0034969)2.81880401
157regulation of cilium movement (GO:0003352)2.81238831
158cellular modified amino acid catabolic process (GO:0042219)2.80841470
159hormone catabolic process (GO:0042447)2.80131622
160pore complex assembly (GO:0046931)2.79966027
161ribosomal small subunit biogenesis (GO:0042274)2.79378992
162DNA conformation change (GO:0071103)2.79119980
163maternal placenta development (GO:0001893)2.79075170
164regulation of double-strand break repair via homologous recombination (GO:0010569)2.78501480
165regulation of DNA-dependent DNA replication (GO:0090329)2.74280232
166regulation of double-strand break repair (GO:2000779)2.73320562
167attachment of spindle microtubules to kinetochore (GO:0008608)2.72474335
168histone H4-K16 acetylation (GO:0043984)2.71276225
169mitotic recombination (GO:0006312)2.70631559
170negative regulation of gene silencing (GO:0060969)2.65886556
171chromatin assembly or disassembly (GO:0006333)2.65803708
172RNA stabilization (GO:0043489)2.65521613

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.88639967
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.64767022
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.57866611
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.51420954
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.51420954
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.51420954
7* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.19175231
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.11531729
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.81142325
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.64741025
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.60726715
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.57218874
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.53478391
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.53092575
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.51020066
16POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.39881663
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.27960391
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.25097421
19NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.18997644
20* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.18318162
21TP63_19390658_ChIP-ChIP_HaCaT_Human2.16893030
22SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.13610940
23ZNF263_19887448_ChIP-Seq_K562_Human2.10481114
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.04768535
25ETS1_20019798_ChIP-Seq_JURKAT_Human1.98539898
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.96929691
27NANOG_18555785_ChIP-Seq_MESCs_Mouse1.96163848
28GABP_17652178_ChIP-ChIP_JURKAT_Human1.90098229
29STAT3_1855785_ChIP-Seq_MESCs_Mouse1.85715027
30YY1_21170310_ChIP-Seq_MESCs_Mouse1.83705962
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.83175157
32* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.79521753
33TCF3_18692474_ChIP-Seq_MEFs_Mouse1.78677873
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.77675689
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.77306792
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.75825163
37* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.75710951
38XRN2_22483619_ChIP-Seq_HELA_Human1.72491619
39SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.72236624
40TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70461183
41* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.64643235
42VDR_21846776_ChIP-Seq_THP-1_Human1.64544564
43AR_21909140_ChIP-Seq_LNCAP_Human1.60445885
44TCF3_18692474_ChIP-Seq_MESCs_Mouse1.60072617
45NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.59352373
46FOXP3_21729870_ChIP-Seq_TREG_Human1.58639772
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.57983242
48MYC_22102868_ChIP-Seq_BL_Human1.57121545
49NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.55380553
50KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.50122190
51NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.49702208
52* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.47529522
53GABP_19822575_ChIP-Seq_HepG2_Human1.46673107
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45903175
55VDR_23849224_ChIP-Seq_CD4+_Human1.44362326
56ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.41706351
57DCP1A_22483619_ChIP-Seq_HELA_Human1.36816647
58KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.36614679
59* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35075256
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.34995896
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.34848710
62SOX2_18555785_ChIP-Seq_MESCs_Mouse1.34779579
63CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.33632398
64TET1_21451524_ChIP-Seq_MESCs_Mouse1.33245008
65* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.32516969
66SRY_22984422_ChIP-ChIP_TESTIS_Rat1.30114344
67TTF2_22483619_ChIP-Seq_HELA_Human1.28731983
68* LXR_22292898_ChIP-Seq_THP-1_Human1.26595978
69CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.25261225
70CIITA_25753668_ChIP-Seq_RAJI_Human1.25002381
71E2F1_21310950_ChIP-Seq_MCF-7_Human1.24493846
72ELF1_17652178_ChIP-ChIP_JURKAT_Human1.24482278
73NOTCH1_21737748_ChIP-Seq_TLL_Human1.24435126
74HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.23491124
75SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.23105370
76KDM5A_27292631_Chip-Seq_BREAST_Human1.21462729
77SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21374528
78ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21327714
79OCT4_18692474_ChIP-Seq_MEFs_Mouse1.20923880
80* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19258542
81* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.19103793
82IRF1_19129219_ChIP-ChIP_H3396_Human1.17369244
83ELK3_25401928_ChIP-Seq_HUVEC_Human1.15733740
84FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15091884
85PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.13740393
86RACK7_27058665_Chip-Seq_MCF-7_Human1.13728780
87EGR1_19374776_ChIP-ChIP_THP-1_Human1.13617645
88SOX2_18692474_ChIP-Seq_MEFs_Mouse1.13523176
89* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.12087097
90* FOXP1_21924763_ChIP-Seq_HESCs_Human1.10449690
91HIF1A_21447827_ChIP-Seq_MCF-7_Human1.09856508
92NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.09841321
93* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.09585668
94YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08861684
95NANOG_18692474_ChIP-Seq_MEFs_Mouse1.08179375
96POU5F1_16518401_ChIP-PET_MESCs_Mouse1.07867435
97SRF_21415370_ChIP-Seq_HL-1_Mouse1.07827517
98PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.07785623
99* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07474054
100ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.07341866
101NANOG_21062744_ChIP-ChIP_HESCs_Human1.06132952
102FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05394403
103TBX5_21415370_ChIP-Seq_HL-1_Mouse1.04945019
104SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.04832322
105SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03890891
106CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03093581
107* P68_20966046_ChIP-Seq_HELA_Human1.02918235
108CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02063582
109SOX2_18692474_ChIP-Seq_MESCs_Mouse1.00719747
110E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99370518
111TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98570167
112CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.98228725
113TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97545237
114KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96011372
115TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95966553
116ELF1_20517297_ChIP-Seq_JURKAT_Human0.92792365
117TFEB_21752829_ChIP-Seq_HELA_Human0.92743676
118NANOG_18692474_ChIP-Seq_MESCs_Mouse0.92525332
119SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.92241634
120SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.91192182
121TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.91121756
122DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91040445
123BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89890889
124* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88497019
125NANOG_16153702_ChIP-ChIP_HESCs_Human0.86433637
126ESR1_15608294_ChIP-ChIP_MCF-7_Human0.86009356
127DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.84629591
128ELK1_19687146_ChIP-ChIP_HELA_Human0.83109127
129CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.82906349
130ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.82890631
131CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.82667091
132HOXB4_20404135_ChIP-ChIP_EML_Mouse0.82355572

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004957_abnormal_blastocyst_morpholog3.92423841
2MP0008057_abnormal_DNA_replication3.92147727
3MP0004264_abnormal_extraembryonic_tissu3.16068512
4MP0006292_abnormal_olfactory_placode3.15246766
5MP0003890_abnormal_embryonic-extraembry3.09493159
6MP0003011_delayed_dark_adaptation3.00413513
7MP0003693_abnormal_embryo_hatching2.89541589
8MP0003806_abnormal_nucleotide_metabolis2.83830430
9MP0005451_abnormal_body_composition2.83776621
10MP0003077_abnormal_cell_cycle2.79158254
11MP0010094_abnormal_chromosome_stability2.78059603
12MP0003111_abnormal_nucleus_morphology2.68493242
13MP0006035_abnormal_mitochondrial_morpho2.45599416
14MP0003123_paternal_imprinting2.45241227
15MP0005075_abnormal_melanosome_morpholog2.44316798
16MP0004233_abnormal_muscle_weight2.33687409
17MP0010352_gastrointestinal_tract_polyps2.23998931
18MP0005394_taste/olfaction_phenotype2.15292627
19MP0005499_abnormal_olfactory_system2.15292627
20MP0001672_abnormal_embryogenesis/_devel2.10608570
21MP0005380_embryogenesis_phenotype2.10608570
22MP0003121_genomic_imprinting2.08816860
23MP0003122_maternal_imprinting2.08151451
24MP0002254_reproductive_system_inflammat2.03275502
25MP0003984_embryonic_growth_retardation1.99100467
26MP0002088_abnormal_embryonic_growth/wei1.98373558
27MP0002396_abnormal_hematopoietic_system1.97217379
28MP0003705_abnormal_hypodermis_morpholog1.93766156
29MP0000350_abnormal_cell_proliferation1.93615561
30MP0002332_abnormal_exercise_endurance1.84546905
31MP0008058_abnormal_DNA_repair1.83626805
32MP0001730_embryonic_growth_arrest1.79835257
33MP0008932_abnormal_embryonic_tissue1.79793943
34MP0010030_abnormal_orbit_morphology1.77975536
35MP0002653_abnormal_ependyma_morphology1.76214479
36MP0000537_abnormal_urethra_morphology1.74232120
37MP0008007_abnormal_cellular_replicative1.72912004
38MP0005266_abnormal_metabolism1.65822054
39MP0001293_anophthalmia1.62030854
40MP0005501_abnormal_skin_physiology1.58215360
41MP0002877_abnormal_melanocyte_morpholog1.55418051
42MP0004185_abnormal_adipocyte_glucose1.55012273
43MP0002086_abnormal_extraembryonic_tissu1.52748248
44MP0006036_abnormal_mitochondrial_physio1.49451514
45MP0002085_abnormal_embryonic_tissue1.48936027
46MP0009379_abnormal_foot_pigmentation1.47288079
47MP0009697_abnormal_copulation1.47154827
48MP0000678_abnormal_parathyroid_gland1.45216406
49MP0001697_abnormal_embryo_size1.43938737
50MP0001346_abnormal_lacrimal_gland1.42445642
51MP0002127_abnormal_cardiovascular_syste1.40037335
52MP0004133_heterotaxia1.40015354
53MP0003186_abnormal_redox_activity1.37768663
54MP0008260_abnormal_autophagy1.37090197
55MP0001661_extended_life_span1.36926699
56MP0004858_abnormal_nervous_system1.36295038
57MP0002084_abnormal_developmental_patter1.35559055
58MP0003718_maternal_effect1.35025273
59MP0002080_prenatal_lethality1.34751275
60MP0000490_abnormal_crypts_of1.34381665
61MP0005623_abnormal_meninges_morphology1.31438443
62MP0004197_abnormal_fetal_growth/weight/1.30955082
63MP0000313_abnormal_cell_death1.29133680
64MP0002163_abnormal_gland_morphology1.25925571
65MP0002796_impaired_skin_barrier1.24547668
66MP0009333_abnormal_splenocyte_physiolog1.21683615
67MP0005257_abnormal_intraocular_pressure1.19916088
68MP0002234_abnormal_pharynx_morphology1.19814051
69MP0001849_ear_inflammation1.15842798
70MP0000358_abnormal_cell_content/1.14758047
71MP0003119_abnormal_digestive_system1.13488703
72MP0002132_abnormal_respiratory_system1.12817139
73MP0002269_muscular_atrophy1.10821288
74MP0003786_premature_aging1.10809018
75MP0009053_abnormal_anal_canal1.08948101
76MP0002092_abnormal_eye_morphology1.08930310
77MP0001529_abnormal_vocalization1.07439977
78MP0005319_abnormal_enzyme/_coenzyme1.06565637
79MP0002932_abnormal_joint_morphology1.04817193
80MP0002160_abnormal_reproductive_system1.04090001
81MP0002970_abnormal_white_adipose1.01724187
82MP0003221_abnormal_cardiomyocyte_apopto1.01722240
83MP0005365_abnormal_bile_salt1.01708064
84MP0005058_abnormal_lysosome_morphology1.00698724
85MP0002019_abnormal_tumor_incidence0.96305625
86MP0010307_abnormal_tumor_latency0.94308526
87MP0002139_abnormal_hepatobiliary_system0.93842752
88MP0005085_abnormal_gallbladder_physiolo0.92859277
89MP0008789_abnormal_olfactory_epithelium0.92644250
90MP0001881_abnormal_mammary_gland0.91276451
91MP0005666_abnormal_adipose_tissue0.88344957
92MP0000749_muscle_degeneration0.88086085
93MP0000049_abnormal_middle_ear0.86997489
94MP0002697_abnormal_eye_size0.86331247
95MP0010234_abnormal_vibrissa_follicle0.86244947
96MP0003942_abnormal_urinary_system0.84422630
97MP0009278_abnormal_bone_marrow0.84053543
98MP0005670_abnormal_white_adipose0.84004585
99MP0008961_abnormal_basal_metabolism0.83900790
100MP0005360_urolithiasis0.83177346
101MP0003941_abnormal_skin_development0.82261454
102MP0008875_abnormal_xenobiotic_pharmacok0.80667251
103MP0008770_decreased_survivor_rate0.80548398
104MP0003315_abnormal_perineum_morphology0.80486703
105MP0001727_abnormal_embryo_implantation0.80386785
106MP0000566_synostosis0.80236055
107MP0002210_abnormal_sex_determination0.79255724
108MP0002114_abnormal_axial_skeleton0.79163887
109MP0003938_abnormal_ear_development0.78397934
110MP0000598_abnormal_liver_morphology0.77840964
111MP0000750_abnormal_muscle_regeneration0.77498275
112MP0002277_abnormal_respiratory_mucosa0.77195431
113MP0003567_abnormal_fetal_cardiomyocyte0.74101892
114MP0005376_homeostasis/metabolism_phenot0.74092551
115MP0004084_abnormal_cardiac_muscle0.73763377
116MP0005076_abnormal_cell_differentiation0.73707994
117MP0000681_abnormal_thyroid_gland0.73691757
118MP0000428_abnormal_craniofacial_morphol0.73273958
119MP0000759_abnormal_skeletal_muscle0.72824811
120MP0000747_muscle_weakness0.72743333
121MP0005023_abnormal_wound_healing0.72699830
122MP0005384_cellular_phenotype0.72271763
123MP0005621_abnormal_cell_physiology0.70881973
124MP0009703_decreased_birth_body0.70686517
125MP0000609_abnormal_liver_physiology0.70533543
126MP0004043_abnormal_pH_regulation0.69851168
127MP0002111_abnormal_tail_morphology0.69719948
128MP0001188_hyperpigmentation0.69678037
129MP0001764_abnormal_homeostasis0.69307785
130MP0009672_abnormal_birth_weight0.68544996
131MP0000003_abnormal_adipose_tissue0.67756625
132MP0005375_adipose_tissue_phenotype0.65939101
133MP0000762_abnormal_tongue_morphology0.65721142
134MP0002233_abnormal_nose_morphology0.65469756
135MP0005330_cardiomyopathy0.65233436
136MP0002925_abnormal_cardiovascular_devel0.64125920
137MP0003137_abnormal_impulse_conducting0.63878765
138MP0004808_abnormal_hematopoietic_stem0.63408420
139MP0003935_abnormal_craniofacial_develop0.63342761
140MP0001145_abnormal_male_reproductive0.62674455
141MP0000432_abnormal_head_morphology0.62555723
142MP0000733_abnormal_muscle_development0.61817858
143MP0002249_abnormal_larynx_morphology0.61543065
144MP0001286_abnormal_eye_development0.59888509
145MP0003283_abnormal_digestive_organ0.55698415

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)5.66583303
2Multiple enchondromatosis (HP:0005701)5.39569302
3Hypochromic microcytic anemia (HP:0004840)5.25846585
4Ependymoma (HP:0002888)4.57900690
5Hepatoblastoma (HP:0002884)4.50739003
6Abnormality of the lower motor neuron (HP:0002366)3.95039340
7Rhabdomyosarcoma (HP:0002859)3.87285129
8Ragged-red muscle fibers (HP:0003200)3.83554472
9Rib fusion (HP:0000902)3.76932892
10Neoplasm of striated muscle (HP:0009728)3.60898952
11Reticulocytopenia (HP:0001896)3.48795620
12Chromosomal breakage induced by crosslinking agents (HP:0003221)3.40867717
13Nephroblastoma (Wilms tumor) (HP:0002667)3.35684196
14Abnormality of cells of the erythroid lineage (HP:0012130)3.24691461
15Chromsome breakage (HP:0040012)3.17229030
16Impulsivity (HP:0100710)3.13809305
17Embryonal renal neoplasm (HP:0011794)3.09814227
18Abnormal mitochondria in muscle tissue (HP:0008316)3.05549582
19Reduced antithrombin III activity (HP:0001976)3.05351908
20Decreased activity of mitochondrial respiratory chain (HP:0008972)3.03690132
21Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.03690132
22Abnormal number of erythroid precursors (HP:0012131)3.01394844
23Abnormal cartilage morphology (HP:0002763)3.01331672
24Abnormality of glycolysis (HP:0004366)3.01232671
25Increased serum pyruvate (HP:0003542)3.01232671
26Trismus (HP:0000211)3.01201874
27Abnormal lung lobation (HP:0002101)2.99235258
28Cholecystitis (HP:0001082)2.95909170
29Abnormal gallbladder physiology (HP:0012438)2.95909170
30Aplastic anemia (HP:0001915)2.91983467
31Rectal fistula (HP:0100590)2.91429972
32Rectovaginal fistula (HP:0000143)2.91429972
33Abnormality of the astrocytes (HP:0100707)2.87277762
34Astrocytoma (HP:0009592)2.87277762
35Hepatocellular necrosis (HP:0001404)2.86523564
36Progressive muscle weakness (HP:0003323)2.86080257
37Broad distal phalanx of finger (HP:0009836)2.81342352
38Testicular atrophy (HP:0000029)2.79336040
39Aplasia/hypoplasia of the humerus (HP:0006507)2.77663433
40Microretrognathia (HP:0000308)2.77490002
41Hyperinsulinemic hypoglycemia (HP:0000825)2.77341318
42Acute encephalopathy (HP:0006846)2.74775875
43Acute necrotizing encephalopathy (HP:0006965)2.73800174
44Vaginal fistula (HP:0004320)2.66515567
45Medulloblastoma (HP:0002885)2.66028530
46Supernumerary spleens (HP:0009799)2.62561443
47Increased serum lactate (HP:0002151)2.61959591
48Meckel diverticulum (HP:0002245)2.61678247
49Abnormality of the salivary glands (HP:0010286)2.61189433
50Microvesicular hepatic steatosis (HP:0001414)2.61135092
51Hepatic necrosis (HP:0002605)2.60883737
52Short humerus (HP:0005792)2.58761219
53Bifid tongue (HP:0010297)2.57927089
54Shawl scrotum (HP:0000049)2.54174201
55Hypoplasia of the fovea (HP:0007750)2.53821170
56Aplasia/Hypoplasia of the fovea (HP:0008060)2.53821170
57Fused cervical vertebrae (HP:0002949)2.52441226
58Macrocytic anemia (HP:0001972)2.51598453
59Intestinal fistula (HP:0100819)2.50433473
60Increased CSF lactate (HP:0002490)2.49581190
61Aplasia/Hypoplasia of the uvula (HP:0010293)2.47165824
62Abnormality of the ileum (HP:0001549)2.46597168
63Achilles tendon contracture (HP:0001771)2.45806182
64Partial duplication of thumb phalanx (HP:0009944)2.45714232
65Mitochondrial inheritance (HP:0001427)2.45255884
66Increased intramyocellular lipid droplets (HP:0012240)2.43200074
67Lactic acidosis (HP:0003128)2.39725486
68Exercise intolerance (HP:0003546)2.39709487
69Angiofibromas (HP:0010615)2.39645137
70Adenoma sebaceum (HP:0009720)2.39645137
71Aplasia/Hypoplasia of the sternum (HP:0006714)2.35655279
72Glioma (HP:0009733)2.35448813
73Hypochromic anemia (HP:0001931)2.35072058
74Tongue fasciculations (HP:0001308)2.34070099
75Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.33506896
76Abnormal protein N-linked glycosylation (HP:0012347)2.33506896
77Abnormal protein glycosylation (HP:0012346)2.33506896
78Abnormal glycosylation (HP:0012345)2.33506896
79Myopathic facies (HP:0002058)2.31968186
80Preauricular skin tag (HP:0000384)2.31483153
81Self-mutilation (HP:0000742)2.30500666
82Increased muscle lipid content (HP:0009058)2.29799435
83Birth length less than 3rd percentile (HP:0003561)2.29190855
84Abnormality of the intrinsic pathway (HP:0010989)2.29065902
85Abnormality of reticulocytes (HP:0004312)2.26547660
86Type I transferrin isoform profile (HP:0003642)2.24845171
87Hyperacusis (HP:0010780)2.22803852
88Abnormality of the anterior horn cell (HP:0006802)2.20150618
89Degeneration of anterior horn cells (HP:0002398)2.20150618
90High anterior hairline (HP:0009890)2.17859420
91Premature ovarian failure (HP:0008209)2.17163533
92Hyperglycinuria (HP:0003108)2.16999406
93Abnormality of the umbilical cord (HP:0010881)2.16477495
94Amyotrophic lateral sclerosis (HP:0007354)2.16457858
95Muscle fibrillation (HP:0010546)2.16064400
96Partial duplication of the phalanx of hand (HP:0009999)2.15981446
97Cerebral edema (HP:0002181)2.15049274
98Proximal placement of thumb (HP:0009623)2.14128148
99Selective tooth agenesis (HP:0001592)2.14122715
100Septate vagina (HP:0001153)2.13078901
101Breast hypoplasia (HP:0003187)2.12322037
102Abnormality of the Achilles tendon (HP:0005109)2.11830840
103Glossoptosis (HP:0000162)2.11620427
104Tetraplegia (HP:0002445)2.11564204
105Small intestinal stenosis (HP:0012848)2.10590527
106Duodenal stenosis (HP:0100867)2.10590527
107Atrophy/Degeneration involving motor neurons (HP:0007373)2.10130557
108Pendular nystagmus (HP:0012043)2.09155765
109Short 5th finger (HP:0009237)2.08674018
110Horseshoe kidney (HP:0000085)2.08519325
111Squamous cell carcinoma (HP:0002860)2.07852416
112Renal duplication (HP:0000075)2.07437582
113Missing ribs (HP:0000921)2.06691606
1143-Methylglutaconic aciduria (HP:0003535)2.04507589
115Sloping forehead (HP:0000340)2.03640128
116Cerebral hypomyelination (HP:0006808)2.03330318
117Horizontal nystagmus (HP:0000666)2.02162258
118Deviation of the thumb (HP:0009603)2.00471980
119Atresia of the external auditory canal (HP:0000413)2.00288333
120Progressive external ophthalmoplegia (HP:0000590)1.99841047
121Centrally nucleated skeletal muscle fibers (HP:0003687)1.99831784
122Skin tags (HP:0010609)1.99680582
123Anomalous pulmonary venous return (HP:0010772)1.97365477
124Gout (HP:0001997)1.94861997
125Pallor (HP:0000980)1.94202628
126Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.93913397
127Malnutrition (HP:0004395)1.93618484
128Oral leukoplakia (HP:0002745)1.91765974
129Insomnia (HP:0100785)1.91129919
130Abnormality of the preputium (HP:0100587)1.89783662
131Myelodysplasia (HP:0002863)1.89472194
132Aplasia/Hypoplasia of the sacrum (HP:0008517)1.88687199
133Facial cleft (HP:0002006)1.88431077
134Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.87554957
135Abnormal number of incisors (HP:0011064)1.87486142
136Rhabdomyolysis (HP:0003201)1.86553670
137Upper motor neuron abnormality (HP:0002127)1.85631499
138Pancytopenia (HP:0001876)1.85397387
139Increased connective tissue (HP:0009025)1.84903216
140Increased hepatocellular lipid droplets (HP:0006565)1.84608097
141Diastasis recti (HP:0001540)1.84254863
142Sparse eyelashes (HP:0000653)1.82472477
143Long palpebral fissure (HP:0000637)1.82372040
144Hypoplasia of the capital femoral epiphysis (HP:0003090)1.82313404
145Abnormal umbilical cord blood vessels (HP:0011403)1.82210728
146Single umbilical artery (HP:0001195)1.82210728
147Abnormality of the fetal cardiovascular system (HP:0010948)1.82210728
148Cleft eyelid (HP:0000625)1.81916542
149Malignant neoplasm of the central nervous system (HP:0100836)1.80681430
150Opisthotonus (HP:0002179)1.80223574
151Abnormality of chromosome stability (HP:0003220)1.80165735
152Abnormality of the fovea (HP:0000493)1.78814383
153Progressive macrocephaly (HP:0004481)1.78595866
154Abnormality of the duodenum (HP:0002246)1.78422795
155Rough bone trabeculation (HP:0100670)1.76698745
156Lipid accumulation in hepatocytes (HP:0006561)1.76489818
157Carpal bone hypoplasia (HP:0001498)1.76156008
158Shoulder girdle muscle weakness (HP:0003547)1.75443803
159Abnormality of the phalanges of the hallux (HP:0010057)1.74972961
160Sensory axonal neuropathy (HP:0003390)1.74448456
161Secondary amenorrhea (HP:0000869)1.74132934
162Truncus arteriosus (HP:0001660)1.73672423
163Abnormality of the gallbladder (HP:0005264)1.73341599
164Absent thumb (HP:0009777)1.73108730
165Abnormalities of placenta or umbilical cord (HP:0001194)1.72492556
166Cholelithiasis (HP:0001081)1.69702499
167Fasciculations (HP:0002380)1.69632686
168Hypokinesia (HP:0002375)1.69341935
169Respiratory difficulties (HP:0002880)1.68855382
170Reticulocytosis (HP:0001923)1.68640732
171Dysphonia (HP:0001618)1.66997449
172Myoglobinuria (HP:0002913)1.66527283
173Emotional lability (HP:0000712)1.66383302

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.93244192
2ERN13.84512119
3VRK23.79506093
4GRK63.44912315
5GRK53.41407922
6SMG13.21390508
7TTK3.18288406
8WEE12.64571990
9BUB12.61699621
10IRAK32.47106966
11CDC72.35753700
12CSF1R2.34223986
13ADRBK22.30826844
14GRK12.17793593
15CDK72.16165317
16ARAF2.04974374
17STK102.01486636
18NEK11.97815775
19TRIB31.94108981
20EEF2K1.91631520
21TGFBR21.87046949
22PLK11.78083333
23BCKDK1.76045738
24PBK1.73710571
25ICK1.66127586
26EPHA21.64919270
27NEK21.63842398
28MATK1.61659557
29TESK11.57730350
30EIF2AK11.57469144
31MAPK71.56433188
32CHEK21.54386059
33BRAF1.54244266
34NME11.46899024
35PAK41.45279166
36GRK71.43926976
37ACVR1B1.39994833
38TYRO31.32122089
39TESK21.25422104
40MOS1.25153399
41DYRK31.17554864
42SRPK11.17520375
43MAP3K101.16647178
44PRKG21.15013658
45STK161.14370806
46BRSK21.10301858
47RPS6KB21.09764026
48CHEK11.06629384
49TAF11.06372172
50PRPF4B1.05377218
51CDK41.05024441
52AURKB1.04796812
53CAMK41.02626822
54FLT31.00251473
55NME21.00166641
56CDK190.98293246
57STK38L0.93827359
58AURKA0.92241254
59AKT30.92177796
60AKT20.89322393
61CSNK1G30.88895564
62DAPK10.88366363
63ILK0.86917057
64ATR0.85777602
65LIMK10.84863818
66LRRK20.84825217
67ABL20.84775059
68TAOK20.84592239
69SIK10.81092987
70PRKD30.79256403
71WNK10.77361583
72MST1R0.75726416
73MAP3K80.74412520
74CDK20.74065135
75PASK0.73924608
76LATS20.72458200
77CSNK1A1L0.71455277
78EIF2AK30.70441733
79VRK10.69242325
80MTOR0.69217967
81EIF2AK20.68518170
82DAPK30.66286943
83TSSK60.64671105
84MAP2K60.63405899
85BRSK10.62438647
86PDK20.62399389
87ADRBK10.61557269
88PDK40.60860906
89PDK30.60860906
90ALK0.60372542
91HIPK20.59489048
92ATM0.59052282
93PRKCI0.56687604
94IRAK20.55802237
95PAK10.55195587
96TGFBR10.54996093
97RPS6KA50.54883215
98CDK11A0.52451778
99PLK40.51618628
100CDK140.51240112
101SCYL20.51117559
102RAF10.50862402
103STK40.49144758
104CSNK1G10.47790181
105PKN20.47633109
106MAP2K40.45218224
107PIM20.44209761
108MAPKAPK30.43927957
109CDK80.43615673
110CDK150.43357148
111CDK10.42769842
112RPS6KA40.42763838
113PLK30.41702325
114MARK20.39474095
115CDK180.39384973
116CAMK1D0.39080672
117CSNK1E0.38287596
118RPS6KL10.37150210
119RPS6KC10.37150210
120CDK90.37007251
121CSNK1G20.36452041
122DYRK20.35720550
123MAP3K70.35612205
124CSNK2A10.35217044
125MAPKAPK50.33710061
126KDR0.33575711
127TAOK10.33399334
128PAK20.30739563
129STK240.30081106
130MAPK120.30008171
131CSNK2A20.29016145
132MAP3K110.28988735
133MAP2K30.28810995
134FGFR30.27776313
135PIM10.27704707
136NTRK10.26129087
137ZAK0.24875483
138CCNB10.24018688
139BRD40.22999470
140MAP3K30.21524724
141CSK0.19871274
142OBSCN0.18897016

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.97513812
2Vitamin B6 metabolism_Homo sapiens_hsa007503.88979562
3DNA replication_Homo sapiens_hsa030303.81945441
4Mismatch repair_Homo sapiens_hsa034303.15248121
5One carbon pool by folate_Homo sapiens_hsa006702.80283947
6RNA transport_Homo sapiens_hsa030132.57009192
7Fructose and mannose metabolism_Homo sapiens_hsa000512.41562931
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.41287959
9Base excision repair_Homo sapiens_hsa034102.28603431
10Spliceosome_Homo sapiens_hsa030402.13923069
11Homologous recombination_Homo sapiens_hsa034402.09267366
12* Ribosome_Homo sapiens_hsa030102.04227325
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.02215550
14RNA polymerase_Homo sapiens_hsa030201.94183714
15Cell cycle_Homo sapiens_hsa041101.92543213
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.83950556
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.82167148
18Galactose metabolism_Homo sapiens_hsa000521.79776945
19Proteasome_Homo sapiens_hsa030501.77166415
20Nucleotide excision repair_Homo sapiens_hsa034201.75466476
21Pyrimidine metabolism_Homo sapiens_hsa002401.74367082
22Biosynthesis of amino acids_Homo sapiens_hsa012301.73088191
23Folate biosynthesis_Homo sapiens_hsa007901.68576952
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.68046149
25Carbon metabolism_Homo sapiens_hsa012001.64571955
26Parkinsons disease_Homo sapiens_hsa050121.60658561
27Selenocompound metabolism_Homo sapiens_hsa004501.57183767
28RNA degradation_Homo sapiens_hsa030181.54115636
29Oxidative phosphorylation_Homo sapiens_hsa001901.53933988
30Fanconi anemia pathway_Homo sapiens_hsa034601.53605447
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.51239842
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.44258251
33Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.43305793
34Sulfur relay system_Homo sapiens_hsa041221.43264649
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.41099860
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.40851886
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.40818866
38Fatty acid elongation_Homo sapiens_hsa000621.40576071
39Pentose phosphate pathway_Homo sapiens_hsa000301.38180755
40mRNA surveillance pathway_Homo sapiens_hsa030151.31817510
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25535756
42Drug metabolism - other enzymes_Homo sapiens_hsa009831.24314301
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17127630
44Arachidonic acid metabolism_Homo sapiens_hsa005901.14964950
45Thyroid cancer_Homo sapiens_hsa052161.13553168
46Non-homologous end-joining_Homo sapiens_hsa034501.13041625
47Basal transcription factors_Homo sapiens_hsa030221.07620392
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.07617295
49N-Glycan biosynthesis_Homo sapiens_hsa005101.06940365
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.03700208
51Tryptophan metabolism_Homo sapiens_hsa003801.02066601
52p53 signaling pathway_Homo sapiens_hsa041151.00384375
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98218635
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.97516761
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94784657
56Linoleic acid metabolism_Homo sapiens_hsa005910.92295128
57Alzheimers disease_Homo sapiens_hsa050100.85069040
58alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82003158
59Phenylalanine metabolism_Homo sapiens_hsa003600.81561157
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79116850
61Chemical carcinogenesis_Homo sapiens_hsa052040.78050951
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77021428
63Pyruvate metabolism_Homo sapiens_hsa006200.74156219
64Purine metabolism_Homo sapiens_hsa002300.72992597
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.72101341
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68791987
67Steroid biosynthesis_Homo sapiens_hsa001000.67626282
68Fatty acid degradation_Homo sapiens_hsa000710.66037711
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63450571
70mTOR signaling pathway_Homo sapiens_hsa041500.59766858
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.59109381
72Glutathione metabolism_Homo sapiens_hsa004800.57632476
73Vibrio cholerae infection_Homo sapiens_hsa051100.55802769
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55377352
75Metabolic pathways_Homo sapiens_hsa011000.55136538
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.54120219
77Propanoate metabolism_Homo sapiens_hsa006400.52593383
78Arginine biosynthesis_Homo sapiens_hsa002200.47721774
79Herpes simplex infection_Homo sapiens_hsa051680.47318841
80Complement and coagulation cascades_Homo sapiens_hsa046100.46522166
81Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46497226
82Starch and sucrose metabolism_Homo sapiens_hsa005000.45668930
83Peroxisome_Homo sapiens_hsa041460.41404059
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40484384
85Retinol metabolism_Homo sapiens_hsa008300.37334079
86Protein export_Homo sapiens_hsa030600.36320475
87Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.34860900
88Systemic lupus erythematosus_Homo sapiens_hsa053220.33881143
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33385724
90Cardiac muscle contraction_Homo sapiens_hsa042600.32759817
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32572972
92Lysine degradation_Homo sapiens_hsa003100.32015416
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.31216143
94Viral carcinogenesis_Homo sapiens_hsa052030.30658795
95Arginine and proline metabolism_Homo sapiens_hsa003300.30633458
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30422480
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30079765
98Alcoholism_Homo sapiens_hsa050340.28008715
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.27080937
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26775860
101PPAR signaling pathway_Homo sapiens_hsa033200.26664819
102Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.26130673
103Epstein-Barr virus infection_Homo sapiens_hsa051690.26087600
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.25403411
105Chronic myeloid leukemia_Homo sapiens_hsa052200.25397982
106Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25183352
107Prion diseases_Homo sapiens_hsa050200.24962006
108beta-Alanine metabolism_Homo sapiens_hsa004100.24276193
109Glycosaminoglycan degradation_Homo sapiens_hsa005310.24066572
110Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.23623909
111Acute myeloid leukemia_Homo sapiens_hsa052210.22979244
112Bladder cancer_Homo sapiens_hsa052190.22887095
113Tyrosine metabolism_Homo sapiens_hsa003500.21897163
114Butanoate metabolism_Homo sapiens_hsa006500.21797412
115AMPK signaling pathway_Homo sapiens_hsa041520.21641815
116HTLV-I infection_Homo sapiens_hsa051660.21608737
117Huntingtons disease_Homo sapiens_hsa050160.21500981
118Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.21316082
119Basal cell carcinoma_Homo sapiens_hsa052170.21250899
120Other glycan degradation_Homo sapiens_hsa005110.20968581
121MicroRNAs in cancer_Homo sapiens_hsa052060.20503780
122Sulfur metabolism_Homo sapiens_hsa009200.20299280
123Fatty acid metabolism_Homo sapiens_hsa012120.19723822
124Shigellosis_Homo sapiens_hsa051310.19094212
125Legionellosis_Homo sapiens_hsa051340.18192304
126Apoptosis_Homo sapiens_hsa042100.17678918
127Oocyte meiosis_Homo sapiens_hsa041140.17025377
128Fat digestion and absorption_Homo sapiens_hsa049750.14525077
129Hippo signaling pathway_Homo sapiens_hsa043900.12377247

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