MRPS21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S21P family. Pseudogenes corresponding to this gene are found on chromosomes 1p, 1q, 9p, 10p, 10q, 16q, and 17q. Available sequence data analyses identified splice variants that differ in the 5' UTR; both transcripts encode the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.90625169
2energy coupled proton transport, down electrochemical gradient (GO:0015985)8.54404345
3ATP synthesis coupled proton transport (GO:0015986)8.54404345
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)8.34022697
5regulation of helicase activity (GO:0051095)7.59927978
6respiratory electron transport chain (GO:0022904)7.35379836
7electron transport chain (GO:0022900)7.16360290
8somatic hypermutation of immunoglobulin genes (GO:0016446)6.95740253
9somatic diversification of immune receptors via somatic mutation (GO:0002566)6.95740253
10ribosomal small subunit biogenesis (GO:0042274)6.44043497
11viral transcription (GO:0019083)6.20690306
12translational termination (GO:0006415)5.92410452
13protein neddylation (GO:0045116)5.88957898
14cotranslational protein targeting to membrane (GO:0006613)5.66664748
15SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.61406187
16protein targeting to ER (GO:0045047)5.58620298
17establishment of protein localization to endoplasmic reticulum (GO:0072599)5.35523197
18protein localization to endoplasmic reticulum (GO:0070972)5.32275522
19chaperone-mediated protein transport (GO:0072321)5.27131389
20ribosomal small subunit assembly (GO:0000028)5.13897969
21protein complex biogenesis (GO:0070271)4.97448698
22translational elongation (GO:0006414)4.83414296
23NADH dehydrogenase complex assembly (GO:0010257)4.70514131
24mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.70514131
25mitochondrial respiratory chain complex I assembly (GO:0032981)4.70514131
26viral life cycle (GO:0019058)4.69119573
27cellular protein complex disassembly (GO:0043624)4.65906850
28negative regulation of DNA recombination (GO:0045910)4.57445924
29GTP biosynthetic process (GO:0006183)4.48142380
30mitochondrial respiratory chain complex assembly (GO:0033108)4.43776464
31hydrogen ion transmembrane transport (GO:1902600)4.41630631
32purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.30236174
33ATP biosynthetic process (GO:0006754)4.25120116
34purine nucleoside triphosphate biosynthetic process (GO:0009145)4.22442453
35sequestering of actin monomers (GO:0042989)4.20016146
36somatic diversification of immunoglobulins involved in immune response (GO:0002208)4.13881689
37isotype switching (GO:0045190)4.13881689
38somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)4.13881689
39establishment of protein localization to mitochondrial membrane (GO:0090151)4.11046040
40central nervous system myelination (GO:0022010)4.10879958
41axon ensheathment in central nervous system (GO:0032291)4.10879958
42determination of adult lifespan (GO:0008340)4.03497284
43nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.01289510
44DNA damage response, detection of DNA damage (GO:0042769)4.00156447
45* translation (GO:0006412)3.95442536
46ribosomal large subunit biogenesis (GO:0042273)3.95188686
47translational initiation (GO:0006413)3.93427954
48proton transport (GO:0015992)3.93133933
49proteasome assembly (GO:0043248)3.87123033
50respiratory chain complex IV assembly (GO:0008535)3.86772776
51hydrogen transport (GO:0006818)3.84363169
52transcription elongation from RNA polymerase III promoter (GO:0006385)3.78917361
53termination of RNA polymerase III transcription (GO:0006386)3.78917361
54maturation of SSU-rRNA (GO:0030490)3.78332278
55regulation of mitochondrial translation (GO:0070129)3.75587047
56protein targeting to membrane (GO:0006612)3.74997822
57ribonucleoside triphosphate biosynthetic process (GO:0009201)3.71955281
58protein complex disassembly (GO:0043241)3.71808300
59cytochrome complex assembly (GO:0017004)3.67561170
60oxidative phosphorylation (GO:0006119)3.65231268
61UTP biosynthetic process (GO:0006228)3.63253496
62macromolecular complex disassembly (GO:0032984)3.55712701
63rRNA modification (GO:0000154)3.53179657
64nuclear-transcribed mRNA catabolic process (GO:0000956)3.51501573
65fatty acid elongation (GO:0030497)3.49893969
66protein-cofactor linkage (GO:0018065)3.45379439
67inner mitochondrial membrane organization (GO:0007007)3.44103564
68protein targeting to mitochondrion (GO:0006626)3.41163632
69mismatch repair (GO:0006298)3.40282951
70reciprocal meiotic recombination (GO:0007131)3.38948689
71reciprocal DNA recombination (GO:0035825)3.38948689
72spliceosomal snRNP assembly (GO:0000387)3.36003326
73nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.35063324
74mRNA catabolic process (GO:0006402)3.30276771
75guanosine-containing compound biosynthetic process (GO:1901070)3.28609084
76establishment of protein localization to mitochondrion (GO:0072655)3.26855611
77exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.26769166
78behavioral response to nicotine (GO:0035095)3.20276497
79nucleoside triphosphate biosynthetic process (GO:0009142)3.19132747
80antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.18585283
81ribonucleoprotein complex biogenesis (GO:0022613)3.17962678
82pseudouridine synthesis (GO:0001522)3.14807021
83regulation of cellular amino acid metabolic process (GO:0006521)3.13383215
84peptidyl-histidine modification (GO:0018202)3.12179390
85UTP metabolic process (GO:0046051)3.12005032
86somatic recombination of immunoglobulin gene segments (GO:0016447)3.11081987
87protein localization to mitochondrion (GO:0070585)3.09619905
88establishment of viral latency (GO:0019043)3.09528289
89regulation of oxidative phosphorylation (GO:0002082)3.09213052
90mitochondrial transport (GO:0006839)3.06497257
91antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.04698201
92establishment of integrated proviral latency (GO:0075713)3.03675007
93GPI anchor biosynthetic process (GO:0006506)3.03025785
947-methylguanosine mRNA capping (GO:0006370)3.00529440
95CTP biosynthetic process (GO:0006241)3.00299669
96CTP metabolic process (GO:0046036)3.00299669
97RNA catabolic process (GO:0006401)3.00005120
98RNA capping (GO:0036260)2.98825016
997-methylguanosine RNA capping (GO:0009452)2.98825016
100aerobic respiration (GO:0009060)2.97511901
101rRNA processing (GO:0006364)2.96439033
102DNA deamination (GO:0045006)2.91774043
103L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.91229210
104aldehyde catabolic process (GO:0046185)2.90162490
105signal peptide processing (GO:0006465)2.90034710
106L-methionine salvage (GO:0071267)2.89431625
107L-methionine biosynthetic process (GO:0071265)2.89431625
108amino acid salvage (GO:0043102)2.89431625
109negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.89206234
110DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.88328790
111negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.87736784
112regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.87336733
113rRNA metabolic process (GO:0016072)2.86801282
114nucleoside diphosphate phosphorylation (GO:0006165)2.86271573
115somatic diversification of immunoglobulins (GO:0016445)2.85876190
116positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.85148430
117negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.84899505
118rRNA methylation (GO:0031167)2.84102885
119long-chain fatty acid biosynthetic process (GO:0042759)2.83521706
120cellular component biogenesis (GO:0044085)2.82473773
121neutrophil activation involved in immune response (GO:0002283)2.81176088
122cullin deneddylation (GO:0010388)2.80580800
123signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.78858936
124intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.78858936
125establishment of protein localization to membrane (GO:0090150)2.78662830
126signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.74817167
127signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.74817167
128signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.74817167
129protein targeting (GO:0006605)2.73822486
130heart process (GO:0003015)2.71968263
131heart contraction (GO:0060047)2.71968263
132intracellular protein transmembrane import (GO:0044743)2.71364861
133substantia nigra development (GO:0021762)2.70499119
134mannosylation (GO:0097502)2.70268581
135negative regulation of ligase activity (GO:0051352)2.69840100

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.73162842
2E2F7_22180533_ChIP-Seq_HELA_Human5.02145296
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.75766022
4* GABP_17652178_ChIP-ChIP_JURKAT_Human4.35943359
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.25825386
6* EST1_17652178_ChIP-ChIP_JURKAT_Human3.80736663
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.39072239
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.22761696
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.11801053
10* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.10112842
11ETS1_20019798_ChIP-Seq_JURKAT_Human3.09212299
12BP1_19119308_ChIP-ChIP_Hs578T_Human3.07653604
13* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.97579890
14* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.93843520
15PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.59026924
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.37199616
17SRF_21415370_ChIP-Seq_HL-1_Mouse2.36918737
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.32740583
19* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.29333633
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.27288863
21MYC_18555785_ChIP-Seq_MESCs_Mouse2.10148870
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.07980626
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.07487361
24E2F4_17652178_ChIP-ChIP_JURKAT_Human2.06526642
25* ELK1_19687146_ChIP-ChIP_HELA_Human2.05263144
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.04222343
27VDR_22108803_ChIP-Seq_LS180_Human2.03980503
28DCP1A_22483619_ChIP-Seq_HELA_Human1.95483781
29* VDR_23849224_ChIP-Seq_CD4+_Human1.93905693
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.91266926
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.88977013
32* ELK1_22589737_ChIP-Seq_MCF10A_Human1.78027593
33ZNF274_21170338_ChIP-Seq_K562_Hela1.77917917
34POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.75887494
35MYC_18358816_ChIP-ChIP_MESCs_Mouse1.74914407
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.63651510
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.62272847
38TAF15_26573619_Chip-Seq_HEK293_Human1.61636060
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.61191801
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.59815775
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52305252
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.51492316
43TTF2_22483619_ChIP-Seq_HELA_Human1.48092892
44EWS_26573619_Chip-Seq_HEK293_Human1.46827640
45PADI4_21655091_ChIP-ChIP_MCF-7_Human1.39434755
46FOXP3_21729870_ChIP-Seq_TREG_Human1.37117744
47* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.33038135
48* XRN2_22483619_ChIP-Seq_HELA_Human1.31405735
49ZFP57_27257070_Chip-Seq_ESCs_Mouse1.31015529
50EZH2_22144423_ChIP-Seq_EOC_Human1.30169271
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.28395790
52IRF1_19129219_ChIP-ChIP_H3396_Human1.27036238
53SOX2_18555785_ChIP-Seq_MESCs_Mouse1.26424502
54FOXM1_23109430_ChIP-Seq_U2OS_Human1.25686779
55* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.24338784
56SOX2_16153702_ChIP-ChIP_HESCs_Human1.24219830
57MYC_19030024_ChIP-ChIP_MESCs_Mouse1.22835547
58* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21500010
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20590743
60MYC_18940864_ChIP-ChIP_HL60_Human1.17128942
61IRF8_21731497_ChIP-ChIP_J774_Mouse1.16090551
62NANOG_18555785_ChIP-Seq_MESCs_Mouse1.15608319
63ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.13523740
64* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.12576914
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11250739
66MYC_19079543_ChIP-ChIP_MESCs_Mouse1.09779682
67TP63_19390658_ChIP-ChIP_HaCaT_Human1.09725214
68HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.09434478
69* ER_23166858_ChIP-Seq_MCF-7_Human1.08943294
70E2F1_21310950_ChIP-Seq_MCF-7_Human1.08516357
71ZNF263_19887448_ChIP-Seq_K562_Human1.05565736
72CBX2_27304074_Chip-Seq_ESCs_Mouse1.05122966
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04971529
74IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.04034395
75PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03168060
76PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02896377
77FUS_26573619_Chip-Seq_HEK293_Human1.02138359
78* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.01740248
79FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01199657
80CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01029132
81ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00954934
82BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00814297
83CTBP2_25329375_ChIP-Seq_LNCAP_Human1.00694110
84CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.99480866
85SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.98771141
86SOX17_20123909_ChIP-Seq_XEN_Mouse0.98757402
87CTCF_18555785_ChIP-Seq_MESCs_Mouse0.98472845
88NANOG_16153702_ChIP-ChIP_HESCs_Human0.98154414
89ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94399687
90CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.94117701
91PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.93047563
92SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.92820317
93* GABP_19822575_ChIP-Seq_HepG2_Human0.92454951
94RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92135005
95PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.92081277
96RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.91725868
97MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91183775
98TP53_22573176_ChIP-Seq_HFKS_Human0.90688805
99POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90412041
100FLI1_27457419_Chip-Seq_LIVER_Mouse0.89280695
101* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.89191873
102* STAT1_20625510_ChIP-Seq_HELA_Human0.84232390
103NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.84171074
104* NCOR_22424771_ChIP-Seq_293T_Human0.81253042
105RNF2_27304074_Chip-Seq_NSC_Mouse0.80854731
106EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.80637997
107LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.80410967
108DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.80400511
109SRY_22984422_ChIP-ChIP_TESTIS_Rat0.79506188
110KDM5A_27292631_Chip-Seq_BREAST_Human0.77652038
111ERG_20517297_ChIP-Seq_VCAP_Human0.77058799
112RBPJ_21746931_ChIP-Seq_IB4_Human0.76898160
113MYCN_18555785_ChIP-Seq_MESCs_Mouse0.76813795
114EZH2_27304074_Chip-Seq_ESCs_Mouse0.76662583
115IGF1R_20145208_ChIP-Seq_DFB_Human0.75425021
116NANOG_20526341_ChIP-Seq_ESCs_Human0.75114881
117ETV2_25802403_ChIP-Seq_MESCs_Mouse0.75029175
118HTT_18923047_ChIP-ChIP_STHdh_Human0.74941007
119SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.74444839
120TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.73875279
121PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.72881192
122CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.72780360
123TAL1_26923725_Chip-Seq_HPCs_Mouse0.72766782
124EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.72312506
125POU5F1_16153702_ChIP-ChIP_HESCs_Human0.72099550
126EED_16625203_ChIP-ChIP_MESCs_Mouse0.72071371
127GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.71607673
128P300_19829295_ChIP-Seq_ESCs_Human0.70900007
129SALL4_22934838_ChIP-ChIP_CD34+_Human0.70730068
130KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.69850034
131CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.69095002
132TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.67912995
133NELFA_20434984_ChIP-Seq_ESCs_Mouse0.66655957
134CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.66572434
135MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.66295174
136NANOG_19829295_ChIP-Seq_ESCs_Human0.66007454

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.39045352
2MP0001529_abnormal_vocalization3.56250692
3MP0002837_dystrophic_cardiac_calcinosis3.32846041
4MP0003880_abnormal_central_pattern3.09103858
5MP0006292_abnormal_olfactory_placode2.97980287
6MP0003136_yellow_coat_color2.90407360
7MP0008877_abnormal_DNA_methylation2.86852062
8MP0001905_abnormal_dopamine_level2.84358250
9MP0006036_abnormal_mitochondrial_physio2.40416962
10MP0003186_abnormal_redox_activity2.33770378
11MP0002148_abnormal_hypersensitivity_rea2.27668103
12MP0008058_abnormal_DNA_repair2.23658667
13MP0002163_abnormal_gland_morphology2.16955196
14MP0000372_irregular_coat_pigmentation2.08635769
15MP0000749_muscle_degeneration2.08310874
16MP0005171_absent_coat_pigmentation2.07713126
17MP0006276_abnormal_autonomic_nervous2.03663476
18MP0005451_abnormal_body_composition2.02530016
19MP0003787_abnormal_imprinting1.95491513
20MP0000920_abnormal_myelination1.94475207
21MP0004381_abnormal_hair_follicle1.92817641
22MP0004147_increased_porphyrin_level1.92533397
23MP0005409_darkened_coat_color1.86813408
24MP0002638_abnormal_pupillary_reflex1.82938184
25MP0005379_endocrine/exocrine_gland_phen1.82832581
26MP0001986_abnormal_taste_sensitivity1.79895476
27MP0005408_hypopigmentation1.71656212
28MP0002653_abnormal_ependyma_morphology1.70561833
29MP0003724_increased_susceptibility_to1.70040717
30MP0004142_abnormal_muscle_tone1.69932101
31MP0004145_abnormal_muscle_electrophysio1.68569979
32MP0006035_abnormal_mitochondrial_morpho1.64925813
33MP0009785_altered_susceptibility_to1.61117806
34MP0008995_early_reproductive_senescence1.58210682
35MP0003646_muscle_fatigue1.57845301
36MP0003950_abnormal_plasma_membrane1.55586403
37MP0003693_abnormal_embryo_hatching1.53286755
38MP0004036_abnormal_muscle_relaxation1.52818102
39MP0003122_maternal_imprinting1.52537903
40MP0002876_abnormal_thyroid_physiology1.50923176
41MP0001727_abnormal_embryo_implantation1.46427275
42MP0002277_abnormal_respiratory_mucosa1.46157010
43MP0008875_abnormal_xenobiotic_pharmacok1.45088370
44MP0010094_abnormal_chromosome_stability1.44908024
45MP0005551_abnormal_eye_electrophysiolog1.44262065
46MP0000631_abnormal_neuroendocrine_gland1.43593381
47MP0008789_abnormal_olfactory_epithelium1.39460278
48MP0003121_genomic_imprinting1.39106084
49MP0009046_muscle_twitch1.37244311
50MP0003806_abnormal_nucleotide_metabolis1.36313652
51MP0004957_abnormal_blastocyst_morpholog1.33473507
52MP0002160_abnormal_reproductive_system1.33188709
53MP0010386_abnormal_urinary_bladder1.31472589
54MP0002938_white_spotting1.31467387
55MP0001188_hyperpigmentation1.31313524
56MP0003011_delayed_dark_adaptation1.28400405
57MP0002736_abnormal_nociception_after1.27748134
58MP0010030_abnormal_orbit_morphology1.26625175
59MP0005084_abnormal_gallbladder_morpholo1.25329612
60MP0005075_abnormal_melanosome_morpholog1.23514033
61MP0003195_calcinosis1.22789139
62MP0005330_cardiomyopathy1.21820038
63MP0001485_abnormal_pinna_reflex1.20824739
64MP0000049_abnormal_middle_ear1.18719617
65MP0003938_abnormal_ear_development1.17319207
66MP0001293_anophthalmia1.17247559
67MP0004742_abnormal_vestibular_system1.17118041
68MP0004215_abnormal_myocardial_fiber1.16210983
69MP0002572_abnormal_emotion/affect_behav1.15683368
70MP0002272_abnormal_nervous_system1.14578201
71MP0000955_abnormal_spinal_cord1.14468594
72MP0002557_abnormal_social/conspecific_i1.14389995
73MP0005253_abnormal_eye_physiology1.12835622
74MP0003137_abnormal_impulse_conducting1.12434690
75MP0002132_abnormal_respiratory_system1.11428870
76MP0005499_abnormal_olfactory_system1.11055927
77MP0005394_taste/olfaction_phenotype1.11055927
78MP0002972_abnormal_cardiac_muscle1.10724941
79MP0006082_CNS_inflammation1.10389779
80MP0003786_premature_aging1.09957451
81MP0003635_abnormal_synaptic_transmissio1.08671359
82MP0005000_abnormal_immune_tolerance1.08201501
83MP0000566_synostosis1.07074265
84MP0005671_abnormal_response_to1.06787188
85MP0004084_abnormal_cardiac_muscle1.06372521
86MP0005636_abnormal_mineral_homeostasis1.06121307
87MP0002735_abnormal_chemical_nociception1.05358633
88MP0002095_abnormal_skin_pigmentation1.05034267
89MP0008872_abnormal_physiological_respon1.04199756
90MP0000750_abnormal_muscle_regeneration1.04143167
91MP0003567_abnormal_fetal_cardiomyocyte1.04058520
92MP0003077_abnormal_cell_cycle1.03418553
93MP0001968_abnormal_touch/_nociception1.02936418
94MP0002295_abnormal_pulmonary_circulatio1.01756082
95MP0001970_abnormal_pain_threshold1.01711402
96MP0001542_abnormal_bone_strength1.01662651
97MP0001835_abnormal_antigen_presentation0.98869124
98MP0005646_abnormal_pituitary_gland0.98559014
99MP0005389_reproductive_system_phenotype0.97765312
100MP0004133_heterotaxia0.97733283
101MP0000751_myopathy0.95955314
102MP0003315_abnormal_perineum_morphology0.95774783
103MP0005423_abnormal_somatic_nervous0.95610513
104MP0005025_abnormal_response_to0.95483499
105MP0005165_increased_susceptibility_to0.94367718
106MP0002734_abnormal_mechanical_nocicepti0.93701760
107MP0004043_abnormal_pH_regulation0.92924649
108MP0002090_abnormal_vision0.91402291
109MP0002210_abnormal_sex_determination0.91340030
110MP0004484_altered_response_of0.89440236
111MP0003718_maternal_effect0.89430728
112MP0003941_abnormal_skin_development0.88734360
113MP0001286_abnormal_eye_development0.87823806
114MP0005332_abnormal_amino_acid0.87549307
115MP0002067_abnormal_sensory_capabilities0.87444609
116MP0002063_abnormal_learning/memory/cond0.87076973
117MP0004270_analgesia0.86865265
118MP0001440_abnormal_grooming_behavior0.86805874
119MP0002233_abnormal_nose_morphology0.86761604
120MP0001346_abnormal_lacrimal_gland0.86675068
121MP0008260_abnormal_autophagy0.85351021
122MP0003111_abnormal_nucleus_morphology0.85130113
123MP0009697_abnormal_copulation0.85113023
124MP0005620_abnormal_muscle_contractility0.85071916
125MP0002184_abnormal_innervation0.84216224
126MP0002909_abnormal_adrenal_gland0.83885684
127MP0005410_abnormal_fertilization0.83282981
128MP0005195_abnormal_posterior_eye0.82891897
129MP0002752_abnormal_somatic_nervous0.82383717
130MP0003123_paternal_imprinting0.82119971
131MP0005645_abnormal_hypothalamus_physiol0.81848754
132MP0000343_altered_response_to0.81260673
133MP0002064_seizures0.80748641
134MP0002106_abnormal_muscle_physiology0.80671349
135MP0000230_abnormal_systemic_arterial0.79072373
136MP0009333_abnormal_splenocyte_physiolog0.77330597
137MP0002234_abnormal_pharynx_morphology0.77027611
138MP0006072_abnormal_retinal_apoptosis0.76928101
139MP0000026_abnormal_inner_ear0.76835482
140MP0004811_abnormal_neuron_physiology0.75132542
141MP0002822_catalepsy0.75018133
142MP0002332_abnormal_exercise_endurance0.74562898
143MP0002733_abnormal_thermal_nociception0.72325973
144MP0002419_abnormal_innate_immunity0.71984245
145MP0002751_abnormal_autonomic_nervous0.71254613
146MP0003828_pulmonary_edema0.69984672
147MP0005369_muscle_phenotype0.69572841
148MP0001984_abnormal_olfaction0.69110187
149MP0005535_abnormal_body_temperature0.68936450
150MP0000538_abnormal_urinary_bladder0.68917196
151MP0002102_abnormal_ear_morphology0.68494390
152MP0009745_abnormal_behavioral_response0.67406687
153MP0001963_abnormal_hearing_physiology0.67160969
154MP0008932_abnormal_embryonic_tissue0.66924498
155MP0008004_abnormal_stomach_pH0.66917992
156MP0002229_neurodegeneration0.66485343

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)7.37467776
2Abnormal mitochondria in muscle tissue (HP:0008316)6.58904596
3Mitochondrial inheritance (HP:0001427)6.45415802
4Ependymoma (HP:0002888)6.21303340
5Progressive macrocephaly (HP:0004481)6.18803771
6Agnosia (HP:0010524)6.10267089
7Acute encephalopathy (HP:0006846)5.99775658
8Increased hepatocellular lipid droplets (HP:0006565)5.37644965
9Hepatocellular necrosis (HP:0001404)5.36938443
10Increased CSF lactate (HP:0002490)5.34777343
11Renal Fanconi syndrome (HP:0001994)4.90209572
12Lipid accumulation in hepatocytes (HP:0006561)4.90149253
13Hepatic necrosis (HP:0002605)4.82964195
14Astrocytoma (HP:0009592)4.52702725
15Abnormality of the astrocytes (HP:0100707)4.52702725
16Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.43410603
17Medulloblastoma (HP:0002885)4.32573668
18Abnormality of cells of the erythroid lineage (HP:0012130)4.23704857
19Cerebral edema (HP:0002181)4.17992770
20Increased intramyocellular lipid droplets (HP:0012240)4.07930573
21Rhabdomyosarcoma (HP:0002859)4.02653540
22Muscle abnormality related to mitochondrial dysfunction (HP:0003800)4.01837532
233-Methylglutaconic aciduria (HP:0003535)3.91764023
24Exercise intolerance (HP:0003546)3.87691852
25Respiratory failure (HP:0002878)3.84092058
26Exertional dyspnea (HP:0002875)3.82918436
27Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.82139652
28Optic disc pallor (HP:0000543)3.81804101
29Abnormality of glycolysis (HP:0004366)3.81107810
30Increased serum pyruvate (HP:0003542)3.81107810
31Glioma (HP:0009733)3.80804452
32Abnormal number of erythroid precursors (HP:0012131)3.69486829
33Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.66935344
34Decreased activity of mitochondrial respiratory chain (HP:0008972)3.66935344
35Parakeratosis (HP:0001036)3.66526226
36Leukodystrophy (HP:0002415)3.65636388
37Neoplasm of the oral cavity (HP:0100649)3.61839110
38Increased muscle lipid content (HP:0009058)3.55347353
39Lactic acidosis (HP:0003128)3.49119231
40Reticulocytopenia (HP:0001896)3.35321742
41Abnormality of renal resorption (HP:0011038)3.28869584
42Increased serum lactate (HP:0002151)3.28688289
43Biliary tract neoplasm (HP:0100574)3.23117358
44Respiratory difficulties (HP:0002880)3.21185642
45Macrocytic anemia (HP:0001972)3.18660271
46Angiofibromas (HP:0010615)2.91179534
47Adenoma sebaceum (HP:0009720)2.91179534
48Congenital ichthyosiform erythroderma (HP:0007431)2.80693278
49Neoplasm of striated muscle (HP:0009728)2.73962752
50Glycosuria (HP:0003076)2.71377225
51Abnormality of urine glucose concentration (HP:0011016)2.71377225
52Abnormality of the salivary glands (HP:0010286)2.64600136
53Pallor (HP:0000980)2.56172838
54Aplastic anemia (HP:0001915)2.52834471
55Hyperphosphaturia (HP:0003109)2.49782542
56X-linked dominant inheritance (HP:0001423)2.47757304
57Neoplasm of the rectum (HP:0100743)2.46365952
58Pancreatic cysts (HP:0001737)2.42570375
59Oral leukoplakia (HP:0002745)2.35642613
60CNS demyelination (HP:0007305)2.25456234
61Abnormal hemoglobin (HP:0011902)2.23708295
62Hypothermia (HP:0002045)2.23168323
63Molar tooth sign on MRI (HP:0002419)2.23124534
64Abnormality of midbrain morphology (HP:0002418)2.23124534
65Basal cell carcinoma (HP:0002671)2.20578193
66Muscle hypertrophy of the lower extremities (HP:0008968)2.20247962
67Neuroblastic tumors (HP:0004376)2.19593039
68Peripheral primitive neuroectodermal neoplasm (HP:0030067)2.19593039
69Neuroblastoma (HP:0003006)2.19593039
70Primitive neuroectodermal tumor (HP:0030065)2.19593039
71Pancreatic fibrosis (HP:0100732)2.17279523
72Amaurosis fugax (HP:0100576)2.16102838
73Abnormal urine phosphate concentration (HP:0012599)2.15860378
74Amniotic constriction ring (HP:0009775)2.15069479
75Abnormality of placental membranes (HP:0011409)2.15069479
76Abnormality of the labia minora (HP:0012880)2.14638311
77Neoplasm of the small intestine (HP:0100833)2.14368587
78Renal tubular dysfunction (HP:0000124)2.11137007
79Aplasia/Hypoplasia of the sacrum (HP:0008517)2.09648932
80True hermaphroditism (HP:0010459)2.06938042
81Lethargy (HP:0001254)2.05752828
82Septo-optic dysplasia (HP:0100842)2.01938266
83Neuroendocrine neoplasm (HP:0100634)1.99322571
84Sensory axonal neuropathy (HP:0003390)1.97810763
85Neoplasm of the colon (HP:0100273)1.97786281
86Calf muscle hypertrophy (HP:0008981)1.97693545
87Myokymia (HP:0002411)1.95614113
88Atonic seizures (HP:0010819)1.91642011
89Meckel diverticulum (HP:0002245)1.91455477
90Colon cancer (HP:0003003)1.90012326
91Absent septum pellucidum (HP:0001331)1.87143928
92Emotional lability (HP:0000712)1.85359084
93Neoplasm of the liver (HP:0002896)1.85208039
94Aplasia/hypoplasia of the uterus (HP:0008684)1.83214223
95Triphalangeal thumb (HP:0001199)1.82591775
96Vacuolated lymphocytes (HP:0001922)1.82499102
97Abnormality of the ileum (HP:0001549)1.80152365
98Nephronophthisis (HP:0000090)1.79938918
99Focal motor seizures (HP:0011153)1.79770871
100Abnormality of the axillary hair (HP:0100134)1.79044522
101Abnormality of secondary sexual hair (HP:0009888)1.79044522
102Type II lissencephaly (HP:0007260)1.77820206
103Supernumerary spleens (HP:0009799)1.77169021
104CNS hypomyelination (HP:0003429)1.76879484
105Blindness (HP:0000618)1.75918924
106Aplasia/Hypoplasia of the uvula (HP:0010293)1.74992285
107Short tibia (HP:0005736)1.73877638
108Abnormal ciliary motility (HP:0012262)1.73767262
109Abnormal biliary tract morphology (HP:0012440)1.71573561
110Type I transferrin isoform profile (HP:0003642)1.71410094
111Pheochromocytoma (HP:0002666)1.71272266
112Sclerocornea (HP:0000647)1.70351728
113Generalized aminoaciduria (HP:0002909)1.68181248
114Abnormal pupillary function (HP:0007686)1.67996628
115Patchy hypopigmentation of hair (HP:0011365)1.66156887
116Hypoglycemic coma (HP:0001325)1.65844079
117Conjunctival hamartoma (HP:0100780)1.64796141
118Cerebral hypomyelination (HP:0006808)1.64787615
119Abnormality of the septum pellucidum (HP:0007375)1.64237308
120Hyperglycinemia (HP:0002154)1.64120490
121Palpitations (HP:0001962)1.63922422
122Congenital, generalized hypertrichosis (HP:0004540)1.62914445
123Hypoplastic left heart (HP:0004383)1.61868520
124Medial flaring of the eyebrow (HP:0010747)1.61512919
125Hepatosplenomegaly (HP:0001433)1.60681630
126Sudden death (HP:0001699)1.59647517
127Microvesicular hepatic steatosis (HP:0001414)1.57863099
128Vomiting (HP:0002013)1.57777543
129Increased IgM level (HP:0003496)1.57437212
130Cerebral hemorrhage (HP:0001342)1.56378852
131Gliosis (HP:0002171)1.55544412
132Congenital malformation of the right heart (HP:0011723)1.53993383
133Double outlet right ventricle (HP:0001719)1.53993383
134Hypoplasia of the uterus (HP:0000013)1.52982097
135Congenital sensorineural hearing impairment (HP:0008527)1.51871468
136Nasolacrimal duct obstruction (HP:0000579)1.51278647
137Methylmalonic acidemia (HP:0002912)1.50675429
138Septate vagina (HP:0001153)1.49767899
139Paralysis (HP:0003470)1.46996013
140Methylmalonic aciduria (HP:0012120)1.45301409
141Recurrent abscess formation (HP:0002722)1.43894835
142Erythroderma (HP:0001019)1.42992893
143Dicarboxylic aciduria (HP:0003215)1.37651304
144Abnormality of dicarboxylic acid metabolism (HP:0010995)1.37651304
145Stenosis of the external auditory canal (HP:0000402)1.37396713
146Hypoplastic heart (HP:0001961)1.36802482
147Axonal loss (HP:0003447)1.35410370
148White forelock (HP:0002211)1.34668120
149Degeneration of the lateral corticospinal tracts (HP:0002314)1.34284169
150Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.34284169
151Popliteal pterygium (HP:0009756)1.32865711
152Poor head control (HP:0002421)1.32489950

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PAK45.00002534
2MAP4K24.69872231
3VRK24.27186532
4NME24.23170906
5STK393.31332504
6MST43.06682014
7STK162.93275742
8PBK2.90966244
9NME12.89224189
10ARAF2.53153096
11MYLK2.36160827
12PIM22.29239858
13BMPR1B2.28648069
14CDC72.24737885
15OXSR12.14302083
16CASK2.11898268
17TLK12.11528800
18WNK42.10335849
19MAP3K122.06011987
20GRK72.04083771
21PDK21.90591509
22VRK11.89478136
23OBSCN1.83776538
24BCR1.82463182
25MUSK1.82452178
26NUAK11.71039485
27LIMK11.52117611
28GRK51.51813425
29BUB11.48042722
30BLK1.46944498
31BMPR21.43866523
32EIF2AK31.38478684
33ADRBK21.37978136
34CDK191.34581880
35IRAK31.32301662
36TTK1.31417218
37IRAK41.28774400
38ABL21.28510769
39PLK31.24641439
40CCNB11.23582132
41TAF11.22391426
42BRAF1.21665882
43INSRR1.21167248
44PASK1.20708822
45PKN11.18158366
46MAPKAPK51.17925355
47TNIK1.16123689
48SRPK11.11831183
49PIK3CG1.05947277
50BCKDK1.03140989
51EIF2AK11.03123919
52NEK10.99514232
53ACVR1B0.99505726
54TRIM280.98843780
55DYRK30.98784320
56DYRK20.97669480
57ILK0.95460899
58MAP3K40.94298213
59MARK10.93943489
60WEE10.91695267
61PRKCG0.91022649
62TSSK60.87557844
63PLK10.86824355
64CAMK2D0.85535469
65BRSK20.83555749
66ZAK0.83027238
67RIPK40.78582039
68CAMK2B0.77003820
69CSNK1G10.76345376
70ADRBK10.76006555
71DAPK30.75947335
72TXK0.75560687
73IRAK20.75082436
74ROCK20.73766520
75MKNK20.72947079
76PHKG10.71615274
77PHKG20.71615274
78CSNK1G20.71550408
79AURKB0.71179004
80CHEK20.70837792
81PNCK0.69829180
82IRAK10.69171681
83RPS6KA50.69049181
84MAP3K140.68853068
85DAPK20.68849453
86KDR0.67953197
87TRPM70.67408340
88CSNK1D0.67005860
89ATR0.65797863
90STK240.64392699
91PRKCE0.63477569
92CSNK1G30.63336975
93IKBKB0.62160172
94PLK40.61840619
95MST1R0.61807866
96PLK20.61369874
97NEK60.61298028
98CAMK2A0.60549115
99PIK3CA0.60434547
100TGFBR10.59210306
101EIF2AK20.58977104
102PRKCQ0.58389297
103PINK10.57374152
104CSNK1A1L0.56785293
105WNK30.55561896
106UHMK10.54661190
107CAMK2G0.54625323
108MOS0.54272046
109CDK80.53369627
110EPHA40.53202673
111TESK20.53009812
112DAPK10.52150828
113BRSK10.49884712
114FGR0.49438418
115MET0.48548447
116MAP2K70.48046168
117STK40.46524885
118CSNK1A10.46423105
119TEC0.46403735
120MINK10.45601306
121TESK10.45284713
122PRKACA0.45196968
123FGFR20.45171244
124LYN0.42997211
125MAP2K20.42358210
126WNK10.42357924
127CSNK2A10.42319811
128CSNK1E0.42163359
129SYK0.42160547
130CDK30.41785198
131NTRK20.41673912
132MKNK10.41290998
133IKBKE0.41046204
134CLK10.40751042
135PAK30.39531703
136PAK10.39499614
137YES10.38624427
138AURKA0.37517781
139FRK0.37500810
140PRKCD0.37146119
141DYRK1A0.36243788
142CSNK2A20.36158394
143TBK10.35185152
144MAP3K30.32159457
145LRRK20.32150128
146GRK10.31838322
147MAPK150.30697645
148MAPK130.30403623
149MAPK40.29853412

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001906.23006454
2Parkinsons disease_Homo sapiens_hsa050125.25797422
3* Ribosome_Homo sapiens_hsa030105.10059822
4Alzheimers disease_Homo sapiens_hsa050104.02755369
5Huntingtons disease_Homo sapiens_hsa050163.70142601
6Proteasome_Homo sapiens_hsa030503.54428830
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.49375866
8Protein export_Homo sapiens_hsa030603.39911874
9RNA polymerase_Homo sapiens_hsa030202.70845957
10Cardiac muscle contraction_Homo sapiens_hsa042602.62844293
11Fatty acid elongation_Homo sapiens_hsa000622.07251500
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.97396150
13Collecting duct acid secretion_Homo sapiens_hsa049661.63165773
14Nicotine addiction_Homo sapiens_hsa050331.61823597
15One carbon pool by folate_Homo sapiens_hsa006701.43588363
16Sulfur metabolism_Homo sapiens_hsa009201.42851820
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.42177647
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38071966
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.38067060
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.37964594
21Pyrimidine metabolism_Homo sapiens_hsa002401.35081460
22Fanconi anemia pathway_Homo sapiens_hsa034601.34990590
23Steroid biosynthesis_Homo sapiens_hsa001001.34822961
24RNA transport_Homo sapiens_hsa030131.22120230
25Rheumatoid arthritis_Homo sapiens_hsa053231.19545456
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.15705340
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.12282447
28Base excision repair_Homo sapiens_hsa034101.12046027
29Arachidonic acid metabolism_Homo sapiens_hsa005901.07795631
30Vibrio cholerae infection_Homo sapiens_hsa051101.06434915
31Ether lipid metabolism_Homo sapiens_hsa005651.03602588
32Graft-versus-host disease_Homo sapiens_hsa053321.01312532
33Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97178390
34Glutathione metabolism_Homo sapiens_hsa004800.95199386
35Allograft rejection_Homo sapiens_hsa053300.94200234
36Metabolic pathways_Homo sapiens_hsa011000.85040073
37Linoleic acid metabolism_Homo sapiens_hsa005910.80958990
38Purine metabolism_Homo sapiens_hsa002300.80706268
39Sphingolipid metabolism_Homo sapiens_hsa006000.79128950
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78621631
41Taste transduction_Homo sapiens_hsa047420.78075791
42Cysteine and methionine metabolism_Homo sapiens_hsa002700.71772028
43Propanoate metabolism_Homo sapiens_hsa006400.70624178
44Autoimmune thyroid disease_Homo sapiens_hsa053200.70493194
45Spliceosome_Homo sapiens_hsa030400.70471390
46Selenocompound metabolism_Homo sapiens_hsa004500.70318252
47Asthma_Homo sapiens_hsa053100.70241959
48Basal transcription factors_Homo sapiens_hsa030220.69128247
49Nucleotide excision repair_Homo sapiens_hsa034200.67639366
50Homologous recombination_Homo sapiens_hsa034400.66852232
51GABAergic synapse_Homo sapiens_hsa047270.66406740
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65953730
53Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.65214908
54Phenylalanine metabolism_Homo sapiens_hsa003600.64205621
55Phagosome_Homo sapiens_hsa041450.63106392
56Tyrosine metabolism_Homo sapiens_hsa003500.62597286
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61453016
58Vitamin B6 metabolism_Homo sapiens_hsa007500.60005197
59Pyruvate metabolism_Homo sapiens_hsa006200.59589486
60Folate biosynthesis_Homo sapiens_hsa007900.59565688
61Morphine addiction_Homo sapiens_hsa050320.58588514
62Non-homologous end-joining_Homo sapiens_hsa034500.56607812
63Histidine metabolism_Homo sapiens_hsa003400.55445554
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54392925
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53741204
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49510519
67Phototransduction_Homo sapiens_hsa047440.48254943
68Tryptophan metabolism_Homo sapiens_hsa003800.47441776
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46293629
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45345454
71Serotonergic synapse_Homo sapiens_hsa047260.45257569
72Other glycan degradation_Homo sapiens_hsa005110.44823819
73Nitrogen metabolism_Homo sapiens_hsa009100.44504180
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44362069
75RNA degradation_Homo sapiens_hsa030180.44190631
76Arginine and proline metabolism_Homo sapiens_hsa003300.43990481
77Peroxisome_Homo sapiens_hsa041460.43155680
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43006395
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42190443
80Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.42048728
81Type I diabetes mellitus_Homo sapiens_hsa049400.41999808
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41658734
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40679767
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40403143
85DNA replication_Homo sapiens_hsa030300.39278918
86Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.38613678
87Cell cycle_Homo sapiens_hsa041100.38589748
88Vitamin digestion and absorption_Homo sapiens_hsa049770.38564033
89Mismatch repair_Homo sapiens_hsa034300.38012183
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37884284
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.34413483
92Basal cell carcinoma_Homo sapiens_hsa052170.34204406
93Regulation of autophagy_Homo sapiens_hsa041400.34123809
94Butanoate metabolism_Homo sapiens_hsa006500.33672678
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.33571175
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33068124
97Hematopoietic cell lineage_Homo sapiens_hsa046400.32140956
98Olfactory transduction_Homo sapiens_hsa047400.32079897
99Pertussis_Homo sapiens_hsa051330.30852313
100Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.30837369
101Hedgehog signaling pathway_Homo sapiens_hsa043400.28903991
102Chemical carcinogenesis_Homo sapiens_hsa052040.28232762
103Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.27938397
104Malaria_Homo sapiens_hsa051440.27587702
105Glutamatergic synapse_Homo sapiens_hsa047240.27536030
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27475273
107Systemic lupus erythematosus_Homo sapiens_hsa053220.26713580
108mRNA surveillance pathway_Homo sapiens_hsa030150.24710147
109Carbon metabolism_Homo sapiens_hsa012000.24416686
110Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24166075
111Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.23652392
112Synaptic vesicle cycle_Homo sapiens_hsa047210.22340192
113Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.22217612
114Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.22202799
115Fatty acid degradation_Homo sapiens_hsa000710.21266106
116Caffeine metabolism_Homo sapiens_hsa002320.21084106
117Circadian entrainment_Homo sapiens_hsa047130.21083604
118Epstein-Barr virus infection_Homo sapiens_hsa051690.19473088
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.19463619
120N-Glycan biosynthesis_Homo sapiens_hsa005100.19064634
121Biosynthesis of amino acids_Homo sapiens_hsa012300.18282437
122Sulfur relay system_Homo sapiens_hsa041220.17280185
123NOD-like receptor signaling pathway_Homo sapiens_hsa046210.17140616
124Primary immunodeficiency_Homo sapiens_hsa053400.16201032
125beta-Alanine metabolism_Homo sapiens_hsa004100.16193905
126Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.15575775
127African trypanosomiasis_Homo sapiens_hsa051430.15422119
128Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.14499293
129Retinol metabolism_Homo sapiens_hsa008300.11339639
130Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.11098219
131Legionellosis_Homo sapiens_hsa051340.10934354
132Steroid hormone biosynthesis_Homo sapiens_hsa001400.10655433
133Maturity onset diabetes of the young_Homo sapiens_hsa049500.10433916
134Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.09074792
135Mineral absorption_Homo sapiens_hsa049780.08201659
136Salmonella infection_Homo sapiens_hsa051320.06845421
137Lysosome_Homo sapiens_hsa041420.06791358

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