MRPS21P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.06712765
2ATP synthesis coupled proton transport (GO:0015986)7.59332710
3energy coupled proton transport, down electrochemical gradient (GO:0015985)7.59332710
4ribosomal small subunit assembly (GO:0000028)7.17920052
5viral transcription (GO:0019083)6.68107108
6phenol-containing compound catabolic process (GO:0019336)6.61877308
7hormone catabolic process (GO:0042447)6.40239199
8translational termination (GO:0006415)6.20586825
9negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)5.91882677
10negative regulation of multicellular organism growth (GO:0040015)5.55144795
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.50376733
12cotranslational protein targeting to membrane (GO:0006613)5.46772500
13protein targeting to ER (GO:0045047)5.39448084
14maturation of SSU-rRNA (GO:0030490)5.37399703
15ribosomal small subunit biogenesis (GO:0042274)5.30767561
16translational elongation (GO:0006414)5.30321585
17protein localization to endoplasmic reticulum (GO:0070972)5.29232528
18establishment of protein localization to endoplasmic reticulum (GO:0072599)5.11072292
19viral life cycle (GO:0019058)4.73513796
20cellular protein complex disassembly (GO:0043624)4.57882480
21nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.50495785
22sequestering of actin monomers (GO:0042989)4.49890346
23regulation of feeding behavior (GO:0060259)4.42591509
24regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)4.36484934
25pseudouridine synthesis (GO:0001522)4.35750226
26regulation of dendritic cell antigen processing and presentation (GO:0002604)4.32042778
27thyroid hormone generation (GO:0006590)4.30086718
28ATP biosynthetic process (GO:0006754)4.28990194
29positive regulation of cell fate commitment (GO:0010455)4.18819362
30respiratory electron transport chain (GO:0022904)4.16065689
31tongue development (GO:0043586)4.15437981
32electron transport chain (GO:0022900)4.07925984
33positive regulation of cellular response to oxidative stress (GO:1900409)4.05065038
34positive regulation of response to oxidative stress (GO:1902884)4.05065038
35cellular modified amino acid catabolic process (GO:0042219)4.03938223
36positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)3.99799499
37negative regulation of telomere maintenance (GO:0032205)3.97747337
38oxygen transport (GO:0015671)3.97646375
39ribosomal large subunit biogenesis (GO:0042273)3.95839264
40protein complex disassembly (GO:0043241)3.92356832
41heterochromatin organization (GO:0070828)3.86725542
42purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.84685684
43imidazole-containing compound metabolic process (GO:0052803)3.81153294
44translational initiation (GO:0006413)3.79791009
45chaperone-mediated protein transport (GO:0072321)3.79356431
46nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.76546011
47homocysteine metabolic process (GO:0050667)3.75072912
48purine nucleoside triphosphate biosynthetic process (GO:0009145)3.72476115
49regulation of telomere maintenance via telomerase (GO:0032210)3.66226281
50exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.65306023
51macromolecular complex disassembly (GO:0032984)3.63166130
52thyroid hormone metabolic process (GO:0042403)3.61815583
53negative regulation of cell fate specification (GO:0009996)3.57736908
54termination of RNA polymerase III transcription (GO:0006386)3.56295374
55transcription elongation from RNA polymerase III promoter (GO:0006385)3.56295374
56protein targeting to membrane (GO:0006612)3.51487559
57tetrahydrofolate metabolic process (GO:0046653)3.50711294
58nuclear-transcribed mRNA catabolic process (GO:0000956)3.48929837
59mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.48517246
60positive regulation of antigen processing and presentation (GO:0002579)3.48485954
61negative regulation of activin receptor signaling pathway (GO:0032926)3.46889676
62establishment of protein localization to mitochondrial membrane (GO:0090151)3.46641094
63deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.43998244
64negative regulation of cell fate commitment (GO:0010454)3.42181788
65ribonucleoside triphosphate biosynthetic process (GO:0009201)3.41652724
66purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.41651659
67regulation of cilium movement (GO:0003352)3.40714368
68preassembly of GPI anchor in ER membrane (GO:0016254)3.39985405
69translation (GO:0006412)3.35689870
70gas transport (GO:0015669)3.35229786
71mRNA catabolic process (GO:0006402)3.35111510
72nucleotide transmembrane transport (GO:1901679)3.32058273
73folic acid-containing compound biosynthetic process (GO:0009396)3.25724348
74mitochondrial respiratory chain complex I assembly (GO:0032981)3.23569007
75NADH dehydrogenase complex assembly (GO:0010257)3.23569007
76mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.23569007
77regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)3.16450849
78hydrogen ion transmembrane transport (GO:1902600)3.15458507
79protein complex biogenesis (GO:0070271)3.06190688
80reciprocal meiotic recombination (GO:0007131)3.02066769
81reciprocal DNA recombination (GO:0035825)3.02066769
82transcription from mitochondrial promoter (GO:0006390)3.01001060
83proton transport (GO:0015992)3.00176028
84negative regulation of T cell differentiation in thymus (GO:0033085)3.00060907
85RNA catabolic process (GO:0006401)2.99628795
86positive regulation of protein import into nucleus, translocation (GO:0033160)2.99023339
87hydrogen transport (GO:0006818)2.94886624
88negative regulation of response to food (GO:0032096)2.90763794
89negative regulation of appetite (GO:0032099)2.90763794
90mitochondrial respiratory chain complex assembly (GO:0033108)2.89546376
91sequestering of extracellular ligand from receptor (GO:0035581)2.88981669
92superoxide anion generation (GO:0042554)2.87175621
93sleep (GO:0030431)2.85693854
94autophagic vacuole fusion (GO:0000046)2.85406644
95axonemal dynein complex assembly (GO:0070286)2.82765529
96regulation of hydrogen peroxide metabolic process (GO:0010310)2.82474847
97nonmotile primary cilium assembly (GO:0035058)2.81083605
98cellular response to interleukin-15 (GO:0071350)2.72990989
99regulation of mesoderm development (GO:2000380)2.71660846
100L-serine metabolic process (GO:0006563)2.71296619

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.01292126
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.76702306
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.53206241
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.76539732
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.23714325
6VDR_22108803_ChIP-Seq_LS180_Human3.19446794
7CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.03090705
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.87020463
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.61484403
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.58406943
11EZH2_22144423_ChIP-Seq_EOC_Human2.54505235
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.48282276
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.48150714
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.47533478
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.43863138
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.34724972
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.31679333
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.13553323
19ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.13017589
20POU5F1_16153702_ChIP-ChIP_HESCs_Human2.06668227
21SOX2_16153702_ChIP-ChIP_HESCs_Human2.01992484
22VDR_23849224_ChIP-Seq_CD4+_Human1.95368478
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.94641765
24CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.92678750
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.87134117
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.85482487
27E2F4_17652178_ChIP-ChIP_JURKAT_Human1.84425191
28FOXP3_21729870_ChIP-Seq_TREG_Human1.70834165
29BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.67575193
30ETS1_20019798_ChIP-Seq_JURKAT_Human1.66593128
31KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.65389972
32MYC_18358816_ChIP-ChIP_MESCs_Mouse1.65121833
33MYC_18940864_ChIP-ChIP_HL60_Human1.62433292
34TTF2_22483619_ChIP-Seq_HELA_Human1.60950616
35YY1_21170310_ChIP-Seq_MESCs_Mouse1.60721745
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59254424
37ZNF274_21170338_ChIP-Seq_K562_Hela1.58400402
38MYC_19079543_ChIP-ChIP_MESCs_Mouse1.55758875
39RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.53964905
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.51017643
41IRF1_19129219_ChIP-ChIP_H3396_Human1.50335441
42ETV2_25802403_ChIP-Seq_MESCs_Mouse1.48966651
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.47134550
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.45036023
45SRF_21415370_ChIP-Seq_HL-1_Mouse1.42899759
46TP53_22573176_ChIP-Seq_HFKS_Human1.39039849
47FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.38067944
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.37369743
49MYC_19030024_ChIP-ChIP_MESCs_Mouse1.36928246
50E2F1_18555785_ChIP-Seq_MESCs_Mouse1.35270091
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.33760881
52GABP_19822575_ChIP-Seq_HepG2_Human1.32788604
53XRN2_22483619_ChIP-Seq_HELA_Human1.30198515
54EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.28788581
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.28029144
56PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.26827282
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.26120080
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.24102834
59EZH2_27304074_Chip-Seq_ESCs_Mouse1.23904389
60SOX2_18555785_ChIP-Seq_MESCs_Mouse1.22761842
61CTCF_18555785_ChIP-Seq_MESCs_Mouse1.21554673
62SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.21253041
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.19304053
64EED_16625203_ChIP-ChIP_MESCs_Mouse1.18889576
65HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.17758821
66SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15655268
67CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14780842
68GATA6_21074721_ChIP-Seq_CACO-2_Human1.14269295
69AUTS2_25519132_ChIP-Seq_293T-REX_Human1.12697989
70SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.12254251
71FOXH1_21741376_ChIP-Seq_EPCs_Human1.11101227
72LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.05899285
73FOXP1_21924763_ChIP-Seq_HESCs_Human1.05865832
74GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.05521449
75PHF8_20622853_ChIP-Seq_HELA_Human1.03841265
76NANOG_16153702_ChIP-ChIP_HESCs_Human1.03715991
77CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.03673168
78TDRD3_21172665_ChIP-Seq_MCF-7_Human1.03158124
79THAP11_20581084_ChIP-Seq_MESCs_Mouse1.02669269
80TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.01399884
81E2F1_20622854_ChIP-Seq_HELA_Human1.00636133
82ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.00301195
83ERG_20517297_ChIP-Seq_VCAP_Human0.99240182
84TAF2_19829295_ChIP-Seq_ESCs_Human0.97207561
85PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96379473
86RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.96137553
87EGR1_23403033_ChIP-Seq_LIVER_Mouse0.96043422
88JARID2_20064375_ChIP-Seq_MESCs_Mouse0.93189814
89CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.91996061
90SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.91747035
91JARID2_20075857_ChIP-Seq_MESCs_Mouse0.91532766
92TCF3_18692474_ChIP-Seq_MEFs_Mouse0.91131329
93FOXM1_23109430_ChIP-Seq_U2OS_Human0.90878713
94MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.88042918
95HNFA_21074721_ChIP-Seq_CACO-2_Human0.87842073
96SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.85416251
97CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.85017782
98ELF1_20517297_ChIP-Seq_JURKAT_Human0.84250628
99BCL6_27268052_Chip-Seq_Bcells_Human0.84016738
100NELFA_20434984_ChIP-Seq_ESCs_Mouse0.83798345

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting6.58703109
2MP0009379_abnormal_foot_pigmentation4.79826049
3MP0006292_abnormal_olfactory_placode4.72476499
4MP0010030_abnormal_orbit_morphology4.10371537
5MP0002653_abnormal_ependyma_morphology3.97556237
6MP0003878_abnormal_ear_physiology3.37865740
7MP0005377_hearing/vestibular/ear_phenot3.37865740
8MP0001348_abnormal_lacrimal_gland3.14455463
9MP0003121_genomic_imprinting2.94080136
10MP0004858_abnormal_nervous_system2.83591103
11MP0008789_abnormal_olfactory_epithelium2.60035160
12MP0005084_abnormal_gallbladder_morpholo2.36316191
13MP0000015_abnormal_ear_pigmentation2.15370589
14MP0005394_taste/olfaction_phenotype2.02869273
15MP0005499_abnormal_olfactory_system2.02869273
16MP0003787_abnormal_imprinting2.01794503
17MP0004133_heterotaxia2.01420959
18MP0001293_anophthalmia1.91527277
19MP0005083_abnormal_biliary_tract1.80206253
20MP0006072_abnormal_retinal_apoptosis1.77141342
21MP0003959_abnormal_lean_body1.58635942
22MP0005423_abnormal_somatic_nervous1.58035636
23MP0002095_abnormal_skin_pigmentation1.50615186
24MP0009764_decreased_sensitivity_to1.49515792
25MP0000049_abnormal_middle_ear1.45381406
26MP0004147_increased_porphyrin_level1.42716715
27MP0001270_distended_abdomen1.41749586
28MP0003195_calcinosis1.36381209
29MP0000750_abnormal_muscle_regeneration1.31977982
30MP0005551_abnormal_eye_electrophysiolog1.29793044
31MP0001286_abnormal_eye_development1.23658024
32MP0001529_abnormal_vocalization1.22770929
33MP0000343_altered_response_to1.20959316
34MP0001986_abnormal_taste_sensitivity1.19963964
35MP0002234_abnormal_pharynx_morphology1.19742242
36MP0001984_abnormal_olfaction1.18668890
37MP0001790_abnormal_immune_system1.18567054
38MP0005387_immune_system_phenotype1.18567054
39MP0005195_abnormal_posterior_eye1.17280721
40MP0002876_abnormal_thyroid_physiology1.14116391
41MP0000685_abnormal_immune_system1.11772689
42MP0002249_abnormal_larynx_morphology1.10530898
43MP0008872_abnormal_physiological_respon1.10509420
44MP0002938_white_spotting1.10088888
45MP0003938_abnormal_ear_development1.10061571
46MP0001501_abnormal_sleep_pattern1.08153637
47MP0009785_altered_susceptibility_to1.07893765
48MP0003136_yellow_coat_color1.06989104
49MP0005197_abnormal_uvea_morphology1.05371774
50MP0005253_abnormal_eye_physiology1.05194659
51MP0005671_abnormal_response_to1.03009561
52MP0001485_abnormal_pinna_reflex1.01683713
53MP0003011_delayed_dark_adaptation1.01271086
54MP0004742_abnormal_vestibular_system0.98364715
55MP0003186_abnormal_redox_activity0.95847534
56MP0003436_decreased_susceptibility_to0.94502616
57MP0004142_abnormal_muscle_tone0.93800933
58MP0001340_abnormal_eyelid_morphology0.93319183
59MP0005248_abnormal_Harderian_gland0.91778224
60MP0003879_abnormal_hair_cell0.90644025
61MP0001968_abnormal_touch/_nociception0.89902585
62MP0002697_abnormal_eye_size0.88355561
63MP0002177_abnormal_outer_ear0.88304343
64MP0005193_abnormal_anterior_eye0.85500447
65MP0009115_abnormal_fat_cell0.85105515
66MP0000579_abnormal_nail_morphology0.84630451
67MP0001663_abnormal_digestive_system0.79881600
68MP0002736_abnormal_nociception_after0.79526469
69MP0002932_abnormal_joint_morphology0.79409400
70MP0002233_abnormal_nose_morphology0.76637584
71MP0002928_abnormal_bile_duct0.75493732
72MP0003111_abnormal_nucleus_morphology0.72636050
73MP0000631_abnormal_neuroendocrine_gland0.70163339
74MP0002148_abnormal_hypersensitivity_rea0.68879428
75MP0001324_abnormal_eye_pigmentation0.67909645
76MP0000026_abnormal_inner_ear0.67737073
77MP0005174_abnormal_tail_pigmentation0.65970161
78MP0005391_vision/eye_phenotype0.65789350
79MP0001800_abnormal_humoral_immune0.65611269
80MP0000613_abnormal_salivary_gland0.62621601
81MP0001873_stomach_inflammation0.61418635
82MP0003755_abnormal_palate_morphology0.61340203
83MP0003567_abnormal_fetal_cardiomyocyte0.60713493
84MP0003693_abnormal_embryo_hatching0.60294318
85MP0002735_abnormal_chemical_nociception0.59885775
86MP0002752_abnormal_somatic_nervous0.59416622
87MP0000372_irregular_coat_pigmentation0.59066375
88MP0005319_abnormal_enzyme/_coenzyme0.58447725
89MP0002102_abnormal_ear_morphology0.58039472
90MP0005645_abnormal_hypothalamus_physiol0.57781584
91MP0002272_abnormal_nervous_system0.57282989
92MP0002933_joint_inflammation0.56961775
93MP0005408_hypopigmentation0.56791610
94MP0001440_abnormal_grooming_behavior0.54824556
95MP0008877_abnormal_DNA_methylation0.53699232
96MP0005165_increased_susceptibility_to0.53529551
97MP0001542_abnormal_bone_strength0.53321451
98MP0002184_abnormal_innervation0.53108634
99MP0009765_abnormal_xenobiotic_induced0.52611391
100MP0002638_abnormal_pupillary_reflex0.52604018

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)5.93839572
2Abnormality of cells of the erythroid lineage (HP:0012130)5.91605039
3Elevated erythrocyte sedimentation rate (HP:0003565)5.31317358
4Orchitis (HP:0100796)4.58855156
5Peritonitis (HP:0002586)4.16907159
6Cerebellar dysplasia (HP:0007033)3.92399503
7Myositis (HP:0100614)3.88104135
8Type II lissencephaly (HP:0007260)3.78654516
9Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.55476566
10Pallor (HP:0000980)3.53082513
11Increased hepatocellular lipid droplets (HP:0006565)3.44186306
1211 pairs of ribs (HP:0000878)3.28159031
13Molar tooth sign on MRI (HP:0002419)3.06479674
14Abnormality of midbrain morphology (HP:0002418)3.06479674
15Renal Fanconi syndrome (HP:0001994)3.00320097
16Abnormal hemoglobin (HP:0011902)2.98737692
17Lipid accumulation in hepatocytes (HP:0006561)2.95322204
18Aplasia/Hypoplasia of the sacrum (HP:0008517)2.92667141
19Macrocytic anemia (HP:0001972)2.92011805
20Acute necrotizing encephalopathy (HP:0006965)2.86994282
21Rib fusion (HP:0000902)2.86544566
22Missing ribs (HP:0000921)2.86524603
23Chronic bronchitis (HP:0004469)2.86212397
24Flat capital femoral epiphysis (HP:0003370)2.81151787
25Short tibia (HP:0005736)2.80267119
26Irregular vertebral endplates (HP:0003301)2.70963274
27Bifid tongue (HP:0010297)2.64169017
28Broad alveolar ridges (HP:0000187)2.63229904
29Retinal dysplasia (HP:0007973)2.60034079
30Congenital, generalized hypertrichosis (HP:0004540)2.55613906
31Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.52774275
32Mitochondrial inheritance (HP:0001427)2.52564252
33Aplasia/Hypoplasia of the tibia (HP:0005772)2.52293841
34Abnormal respiratory motile cilium physiology (HP:0012261)2.50107375
35Amyloidosis (HP:0011034)2.49513127
36Ankyloglossia (HP:0010296)2.45953008
37Abnormal mitochondria in muscle tissue (HP:0008316)2.45166723
38Abnormality of the heme biosynthetic pathway (HP:0010472)2.42457589
39Pancreatic fibrosis (HP:0100732)2.41331423
40Dynein arm defect of respiratory motile cilia (HP:0012255)2.40747570
41Absent/shortened dynein arms (HP:0200106)2.40747570
42Abnormality of the phalanges of the 5th finger (HP:0004213)2.39029455
43Exertional dyspnea (HP:0002875)2.36779950
44Albinism (HP:0001022)2.31143196
45Broad distal phalanx of finger (HP:0009836)2.30904522
46Abnormal pupillary function (HP:0007686)2.30851448
47Reticulocytopenia (HP:0001896)2.28701953
48Pancreatic islet-cell hyperplasia (HP:0004510)2.27497329
49Pancreatic cysts (HP:0001737)2.26692510
50Abnormality of oral frenula (HP:0000190)2.25944130
51Abnormality of the proximal phalanges of the hand (HP:0009834)2.25173775
52Mesomelia (HP:0003027)2.22694938
53Progressive macrocephaly (HP:0004481)2.21259627
54Short middle phalanx of the 5th finger (HP:0004220)2.20890212
55Acute encephalopathy (HP:0006846)2.14720545
56Multiple enchondromatosis (HP:0005701)2.13077348
57Absent rod-and cone-mediated responses on ERG (HP:0007688)2.12037807
58Concave nail (HP:0001598)2.11502326
59Severe visual impairment (HP:0001141)2.07161544
60Increased CSF lactate (HP:0002490)2.07036483
61Microglossia (HP:0000171)2.06051031
62Delayed epiphyseal ossification (HP:0002663)2.04226687
63Microretrognathia (HP:0000308)1.99979628
64Abnormality of the vertebral endplates (HP:0005106)1.96592223
65Increased intramyocellular lipid droplets (HP:0012240)1.96052724
66Down-sloping shoulders (HP:0200021)1.95979916
67Recurrent cutaneous fungal infections (HP:0011370)1.95906600
68Chronic mucocutaneous candidiasis (HP:0002728)1.95906600
69Aplasia/Hypoplasia of the tongue (HP:0010295)1.94959793
70Abnormality of lateral ventricle (HP:0030047)1.93075066
71Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.92055914
72Abnormality of the anterior horn cell (HP:0006802)1.90086388
73Degeneration of anterior horn cells (HP:0002398)1.90086388
74Hypoplasia of the pons (HP:0012110)1.87510272
75Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.86595086
76Abnormality of the aortic arch (HP:0012303)1.82887268
77Abnormal ciliary motility (HP:0012262)1.82629966
78Gastrointestinal infarctions (HP:0005244)1.81804367
79Colon cancer (HP:0003003)1.81601613
80Cerebral edema (HP:0002181)1.80705678
81Homocystinuria (HP:0002156)1.80587842
82Abnormality of homocysteine metabolism (HP:0010919)1.80587842
83Symphalangism affecting the phalanges of the hand (HP:0009773)1.79164526
84Confusion (HP:0001289)1.78926162
85Anophthalmia (HP:0000528)1.78728877
86Metaphyseal cupping (HP:0003021)1.78143427
87Sclerocornea (HP:0000647)1.77134322
88Neonatal respiratory distress (HP:0002643)1.76910850
89True hermaphroditism (HP:0010459)1.76639163
90Abnormality of the pons (HP:0007361)1.75236623
91Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.74818274
92Broad phalanges of the hand (HP:0009768)1.73155756
93Oral leukoplakia (HP:0002745)1.72924389
94Muscle stiffness (HP:0003552)1.72864178
95Abnormality of renal resorption (HP:0011038)1.70254177
96Synostosis of carpal bones (HP:0005048)1.69968887
97Facial edema (HP:0000282)1.69865609
98Irregular epiphyses (HP:0010582)1.69855815
99Depressed nasal ridge (HP:0000457)1.68904492
100Periorbital edema (HP:0100539)1.68579606

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK22.81379998
2MAP3K62.42072554
3ERN111.4866262
4ZAK1.95590440
5TLK11.93873481
6TIE11.71712105
7BCKDK1.69323056
8EPHB21.68641976
9VRK11.58641886
10MAP3K141.55322965
11VRK21.44778786
12FES1.41223371
13CDK81.33232327
14CCNB11.31225617
15KSR21.29380070
16NME11.27770492
17NTRK31.26019898
18STK161.23056475
19GRK11.22682169
20BMPR1B1.21578608
21BUB11.17811918
22TXK1.16125392
23MAP3K21.15222500
24IKBKB1.11793113
25MAP3K71.10302486
26DYRK31.06283819
27KDR1.03687130
28MKNK20.98628084
29ADRBK20.92556222
30PDK20.91414148
31STK40.90801717
32TAOK30.88468133
33INSRR0.85954510
34WEE10.85493231
35DAPK30.83096818
36CDK40.81013826
37MAP2K20.78751767
38CDK90.78736734
39DYRK20.78192556
40LRRK20.76204073
41MAP2K70.76122749
42UHMK10.75142713
43AURKB0.74940033
44AURKA0.72991518
45CDK150.72719876
46RPS6KA50.71669551
47MAP3K130.71457199
48NUAK10.69365708
49RET0.68299421
50MAP2K10.67614044
51DYRK1B0.67587589
52MAPKAPK50.64669784
53CDK180.64585916
54FRK0.62894293
55CDK11A0.61468841
56RPS6KA60.59972989
57IKBKE0.58437222
58NME20.57482326
59STK30.56661995
60CDK140.56210679
61WNK40.56122359
62PIK3CA0.55493787
63CHEK20.54352677
64MAP3K40.54117578
65TBK10.53731845
66RIPK40.52407922
67NTRK20.51776441
68DYRK1A0.51676200
69RPS6KC10.51345411
70RPS6KL10.51345411
71MARK20.50912137
72CSNK2A10.50729868
73PTK60.46251757
74CHUK0.45791862
75GRK60.44911011
76MAPK150.44222587
77PIK3CG0.41093127
78CSNK2A20.41066659
79PLK10.40472596
80OBSCN0.39141993
81ITK0.36050429
82PRKCA0.35561489
83PKN10.34635306
84ZAP700.34498599
85TEC0.33872268
86ATR0.33792074
87GRK50.33578044
88JAK30.31387285
89PRKACA0.31027156
90PINK10.30090024
91CAMK10.29581250
92ABL20.29579360
93WNK30.29520102
94MUSK0.29285372
95EPHA40.27888555
96MET0.27717528
97SYK0.27038738
98RAF10.26783658
99PRKCG0.26348608
100FGR0.26230817

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.20913430
2Oxidative phosphorylation_Homo sapiens_hsa001904.14961466
3One carbon pool by folate_Homo sapiens_hsa006703.71942259
4Parkinsons disease_Homo sapiens_hsa050123.43762897
5Huntingtons disease_Homo sapiens_hsa050162.72753830
6Homologous recombination_Homo sapiens_hsa034402.64765614
7Alzheimers disease_Homo sapiens_hsa050102.63344575
8Systemic lupus erythematosus_Homo sapiens_hsa053222.54797012
9Primary immunodeficiency_Homo sapiens_hsa053402.46379454
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.45210562
11Cyanoamino acid metabolism_Homo sapiens_hsa004602.25731337
12Cardiac muscle contraction_Homo sapiens_hsa042602.19007141
13Proteasome_Homo sapiens_hsa030502.14557876
14Mismatch repair_Homo sapiens_hsa034302.00674959
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.99164141
16DNA replication_Homo sapiens_hsa030301.95775806
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.91897289
18RNA polymerase_Homo sapiens_hsa030201.90742637
19Spliceosome_Homo sapiens_hsa030401.72567328
20Alcoholism_Homo sapiens_hsa050341.68526174
21Nitrogen metabolism_Homo sapiens_hsa009101.67125333
22RNA degradation_Homo sapiens_hsa030181.65461915
23Selenocompound metabolism_Homo sapiens_hsa004501.59564282
24Protein export_Homo sapiens_hsa030601.40000450
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32908349
26Nucleotide excision repair_Homo sapiens_hsa034201.24846375
27Steroid biosynthesis_Homo sapiens_hsa001001.20585002
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.16995268
29Pyrimidine metabolism_Homo sapiens_hsa002401.09646230
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.05359235
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.01887065
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97093964
33Arachidonic acid metabolism_Homo sapiens_hsa005900.94647693
34Peroxisome_Homo sapiens_hsa041460.93887820
35Base excision repair_Homo sapiens_hsa034100.93544549
36Fatty acid metabolism_Homo sapiens_hsa012120.88625910
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85261558
38N-Glycan biosynthesis_Homo sapiens_hsa005100.84601436
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84431297
40Fanconi anemia pathway_Homo sapiens_hsa034600.83148074
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.80367994
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77259651
43Fatty acid elongation_Homo sapiens_hsa000620.76746000
44Pyruvate metabolism_Homo sapiens_hsa006200.72841319
45Vitamin digestion and absorption_Homo sapiens_hsa049770.72767503
46Basal cell carcinoma_Homo sapiens_hsa052170.71956392
47Intestinal immune network for IgA production_Homo sapiens_hsa046720.71489546
48Adipocytokine signaling pathway_Homo sapiens_hsa049200.71037117
49Asthma_Homo sapiens_hsa053100.70759262
50NF-kappa B signaling pathway_Homo sapiens_hsa040640.67559301
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61444834
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60899412
53Metabolic pathways_Homo sapiens_hsa011000.60027768
54Propanoate metabolism_Homo sapiens_hsa006400.57891744
55Hedgehog signaling pathway_Homo sapiens_hsa043400.57707812
56Purine metabolism_Homo sapiens_hsa002300.55581820
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.52421666
58Linoleic acid metabolism_Homo sapiens_hsa005910.51486711
59Shigellosis_Homo sapiens_hsa051310.51109062
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48153298
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47559992
62Malaria_Homo sapiens_hsa051440.45891067
63Antigen processing and presentation_Homo sapiens_hsa046120.45061092
64Fat digestion and absorption_Homo sapiens_hsa049750.42765733
65Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41825460
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41582748
67Butanoate metabolism_Homo sapiens_hsa006500.41475364
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40530373
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.39971465
70Folate biosynthesis_Homo sapiens_hsa007900.39370285
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38884227
72Phototransduction_Homo sapiens_hsa047440.37856664
73Olfactory transduction_Homo sapiens_hsa047400.35146133
74RNA transport_Homo sapiens_hsa030130.34178424
75Hematopoietic cell lineage_Homo sapiens_hsa046400.33644466
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.32744707
77Allograft rejection_Homo sapiens_hsa053300.32020854
78Chemical carcinogenesis_Homo sapiens_hsa052040.31710637
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.31670837
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.31406995
81Autoimmune thyroid disease_Homo sapiens_hsa053200.31096657
82Retinol metabolism_Homo sapiens_hsa008300.30899853
83Fatty acid degradation_Homo sapiens_hsa000710.30735750
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30102860
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30057708
86TNF signaling pathway_Homo sapiens_hsa046680.29807418
87Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.27536966
88Graft-versus-host disease_Homo sapiens_hsa053320.27406980
89Sphingolipid metabolism_Homo sapiens_hsa006000.25987426
90Phenylalanine metabolism_Homo sapiens_hsa003600.25635073
91Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.23739976
92Pertussis_Homo sapiens_hsa051330.23529502
93Tryptophan metabolism_Homo sapiens_hsa003800.23026811
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22081809
95Insulin resistance_Homo sapiens_hsa049310.18628184
96Insulin secretion_Homo sapiens_hsa049110.18491329
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.18353130
98Epstein-Barr virus infection_Homo sapiens_hsa051690.18008407
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.17748500
100Glutathione metabolism_Homo sapiens_hsa004800.15118554

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