ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	dopamine biosynthetic process (GO:0042416)	9.06615423
2	catecholamine transport (GO:0051937)	7.44770887
3	prepulse inhibition (GO:0060134)	6.86593876
4	phenol-containing compound catabolic process (GO:0019336)	6.86132032
5	catecholamine biosynthetic process (GO:0042423)	5.65044609
6	catechol-containing compound biosynthetic process (GO:0009713)	5.65044609
7	fucose catabolic process (GO:0019317)	5.60361342
8	L-fucose metabolic process (GO:0042354)	5.60361342
9	L-fucose catabolic process (GO:0042355)	5.60361342
10	neurotransmitter biosynthetic process (GO:0042136)	5.52343006
11	alkaloid metabolic process (GO:0009820)	5.43292735
12	cellular response to nicotine (GO:0071316)	5.09620144
13	response to xenobiotic stimulus (GO:0009410)	5.09303088
14	mating behavior (GO:0007617)	4.45693350
15	synaptic transmission, dopaminergic (GO:0001963)	4.41789461
16	neuronal action potential (GO:0019228)	4.40674867
17	protein polyglutamylation (GO:0018095)	4.36734491
18	tyrosine metabolic process (GO:0006570)	4.33733991
19	monoamine transport (GO:0015844)	4.32697736
20	norepinephrine metabolic process (GO:0042415)	4.32423112
21	neurofilament cytoskeleton organization (GO:0060052)	4.31885026
22	neurotransmitter metabolic process (GO:0042133)	4.13958975
23	tyrosine phosphorylation of STAT protein (GO:0007260)	3.99942719
24	response to manganese ion (GO:0010042)	3.94548569
25	mechanosensory behavior (GO:0007638)	3.92471168
26	serotonin metabolic process (GO:0042428)	3.85124074
27	dopamine metabolic process (GO:0042417)	3.83964193
28	response to amphetamine (GO:0001975)	3.80592992
29	negative regulation of neurotransmitter transport (GO:0051589)	3.79426514
30	pyrimidine nucleobase catabolic process (GO:0006208)	3.78418607
31	membrane depolarization during action potential (GO:0086010)	3.77772780
32	response to insecticide (GO:0017085)	3.77066010
33	glycine transport (GO:0015816)	3.73548024
34	response to cocaine (GO:0042220)	3.71616087
35	ovulation cycle (GO:0042698)	3.71504988
36	cysteine metabolic process (GO:0006534)	3.67203412
37	cell migration in hindbrain (GO:0021535)	3.63014777
38	toxin metabolic process (GO:0009404)	3.57331223
39	negative regulation of T cell differentiation in thymus (GO:0033085)	3.52914182
40	response to nitrosative stress (GO:0051409)	3.51608927
41	phenol-containing compound biosynthetic process (GO:0046189)	3.50705730
42	auditory behavior (GO:0031223)	3.48051828
43	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.46345157
44	RNA localization (GO:0006403)	3.45937273
45	inositol phosphate catabolic process (GO:0071545)	3.45782574
46	embryonic body morphogenesis (GO:0010172)	3.45377877
47	phosphorylated carbohydrate dephosphorylation (GO:0046838)	3.42451467
48	inositol phosphate dephosphorylation (GO:0046855)	3.42451467
49	primary amino compound metabolic process (GO:1901160)	3.41588756
50	response to pheromone (GO:0019236)	3.38817440
51	heparin biosynthetic process (GO:0030210)	3.36956715
52	heparin metabolic process (GO:0030202)	3.36956715
53	response to water (GO:0009415)	3.36591540
54	regulation of synaptic vesicle transport (GO:1902803)	3.32911891
55	gamma-aminobutyric acid transport (GO:0015812)	3.29985467
56	regulation of dopamine metabolic process (GO:0042053)	3.29265958
57	regulation of catecholamine metabolic process (GO:0042069)	3.29265958
58	positive regulation of neurological system process (GO:0031646)	3.22401914
59	response to nicotine (GO:0035094)	3.20079158
60	neurotransmitter transport (GO:0006836)	3.19994146
61	neuromuscular synaptic transmission (GO:0007274)	3.19827568
62	regulation of synapse structural plasticity (GO:0051823)	3.19488512
63	photoreceptor cell development (GO:0042461)	3.18290534
64	behavioral response to nicotine (GO:0035095)	3.17984530
65	embryonic retina morphogenesis in camera-type eye (GO:0060059)	3.15630546
66	retinal cone cell development (GO:0046549)	3.15208728
67	nucleobase catabolic process (GO:0046113)	3.14274175
68	eye photoreceptor cell development (GO:0042462)	3.12511651
69	protein localization to cilium (GO:0061512)	3.12432011
70	startle response (GO:0001964)	3.10825210
71	body morphogenesis (GO:0010171)	2.98374797
72	catechol-containing compound metabolic process (GO:0009712)	2.98316418
73	catecholamine metabolic process (GO:0006584)	2.98316418
74	negative regulation of Rho protein signal transduction (GO:0035024)	2.96748913
75	benzene-containing compound metabolic process (GO:0042537)	2.94828244
76	neuron cell-cell adhesion (GO:0007158)	2.93705251
77	synaptic transmission, cholinergic (GO:0007271)	2.90560289
78	neuron-neuron synaptic transmission (GO:0007270)	2.89545986
79	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.88927098
80	regulation of neurotransmitter levels (GO:0001505)	2.88833284
81	neuronal action potential propagation (GO:0019227)	2.83845674
82	fucosylation (GO:0036065)	2.83561539
83	positive regulation of gastrulation (GO:2000543)	2.80905428
84	response to corticosterone (GO:0051412)	2.80681604
85	axonal fasciculation (GO:0007413)	2.78227156
86	sensory perception of smell (GO:0007608)	2.77524268
87	dendritic spine morphogenesis (GO:0060997)	2.77354655
88	establishment of mitochondrion localization (GO:0051654)	2.75719958
89	positive regulation of mitochondrial fission (GO:0090141)	2.73785901
90	protein-cofactor linkage (GO:0018065)	2.72350673
91	regulation of microtubule-based movement (GO:0060632)	2.71789359
92	synapse assembly (GO:0007416)	2.71766682
93	neurotransmitter secretion (GO:0007269)	2.69175639
94	synaptic transmission, glutamatergic (GO:0035249)	2.66886192
95	negative regulation of macrophage differentiation (GO:0045650)	2.65528769
96	polyol catabolic process (GO:0046174)	2.64051273
97	single strand break repair (GO:0000012)	2.63833379
98	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.63544792
99	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.63223953
100	dopamine transport (GO:0015872)	10.3246271

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	3.93258491
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.89144286
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.86737112
4	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.18526897
5	ZNF274_21170338_ChIP-Seq_K562_Hela	3.13363698
6	TAF15_26573619_Chip-Seq_HEK293_Human	2.87532240
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.77176037
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.76203806
9	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.59413276
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.53892755
11	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.47868869
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.42403265
13	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.40695815
14	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.17398967
15	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.03510635
16	REST_21632747_ChIP-Seq_MESCs_Mouse	1.94487960
17	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.94371382
18	VDR_22108803_ChIP-Seq_LS180_Human	1.91148120
19	FUS_26573619_Chip-Seq_HEK293_Human	1.84055830
20	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.79744929
21	P300_19829295_ChIP-Seq_ESCs_Human	1.78498487
22	STAT3_23295773_ChIP-Seq_U87_Human	1.69127075
23	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.68216824
24	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.65958425
25	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.65892084
26	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.64790536
27	RNF2_27304074_Chip-Seq_NSC_Mouse	1.62052353
28	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.61872182
29	AR_21572438_ChIP-Seq_LNCaP_Human	1.61300718
30	AR_25329375_ChIP-Seq_VCAP_Human	1.58894317
31	SMAD4_21799915_ChIP-Seq_A2780_Human	1.58700597
32	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.56701857
33	CBP_20019798_ChIP-Seq_JUKART_Human	1.53015426
34	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.53015426
35	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.51862126
36	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.45391750
37	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.43853685
38	TCF4_23295773_ChIP-Seq_U87_Human	1.43486502
39	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.43037277
40	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.42897579
41	ER_23166858_ChIP-Seq_MCF-7_Human	1.42638578
42	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.41698224
43	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.41651786
44	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.41405229
45	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.41190301
46	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.40731469
47	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.39761676
48	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.38542991
49	EWS_26573619_Chip-Seq_HEK293_Human	1.38433977
50	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.38245509
51	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.37305535
52	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.36517122
53	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.36452809
54	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.36297730
55	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.35784243
56	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.31194294
57	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.28295701
58	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.27564076
59	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.26645606
60	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.25074207
61	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.24452136
62	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.24340222
63	IRF1_19129219_ChIP-ChIP_H3396_Human	1.22781046
64	DROSHA_22980978_ChIP-Seq_HELA_Human	1.21774658
65	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.21712320
66	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.20542910
67	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.19021203
68	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.17879988
69	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.17879988
70	RUNX2_22187159_ChIP-Seq_PCA_Human	1.16893151
71	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.16225974
72	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.14948733
73	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.14948733
74	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.14370835
75	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.14173333
76	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.13885146
77	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.13741721
78	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.12665971
79	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.12470501
80	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.11203171
81	BCAT_22108803_ChIP-Seq_LS180_Human	1.10893769
82	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.10762525
83	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.10336598
84	TP53_22573176_ChIP-Seq_HFKS_Human	1.10309874
85	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.08248120
86	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.07632938
87	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.07252150
88	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.06992236
89	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.06321217
90	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.06193155
91	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.04455221
92	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.04412969
93	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.04073902
94	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.03566399
95	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.03566399
96	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.01705052
97	TCF4_22108803_ChIP-Seq_LS180_Human	1.00624005
98	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.00419847
99	RXR_22108803_ChIP-Seq_LS180_Human	0.98009967
100	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.95797514

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009046_muscle_twitch	4.09755169
2	MP0001986_abnormal_taste_sensitivity	3.53575135
3	MP0005423_abnormal_somatic_nervous	3.20616830
4	MP0001905_abnormal_dopamine_level	3.18553595
5	MP0003880_abnormal_central_pattern	2.99604062
6	MP0001188_hyperpigmentation	2.99114489
7	MP0005646_abnormal_pituitary_gland	2.68170963
8	MP0001968_abnormal_touch/_nociception	2.44687078
9	MP0005187_abnormal_penis_morphology	2.42036607
10	MP0009379_abnormal_foot_pigmentation	2.33739844
11	MP0002272_abnormal_nervous_system	2.31004746
12	MP0000569_abnormal_digit_pigmentation	2.30173334
13	MP0009745_abnormal_behavioral_response	2.27575492
14	MP0003890_abnormal_embryonic-extraembry	2.27192286
15	MP0003635_abnormal_synaptic_transmissio	2.25139661
16	MP0000631_abnormal_neuroendocrine_gland	2.18624875
17	MP0004142_abnormal_muscle_tone	2.18539889
18	MP0006072_abnormal_retinal_apoptosis	2.12939809
19	MP0005645_abnormal_hypothalamus_physiol	2.11230005
20	MP0002735_abnormal_chemical_nociception	2.10414407
21	MP0004859_abnormal_synaptic_plasticity	2.10001603
22	MP0003315_abnormal_perineum_morphology	2.02792466
23	MP0000778_abnormal_nervous_system	2.01610645
24	MP0002822_catalepsy	1.95129686
25	MP0002064_seizures	1.94020330
26	MP0005551_abnormal_eye_electrophysiolog	1.90402699
27	MP0002572_abnormal_emotion/affect_behav	1.80096261
28	MP0002067_abnormal_sensory_capabilities	1.79575427
29	MP0001486_abnormal_startle_reflex	1.76554293
30	MP0005253_abnormal_eye_physiology	1.75414304
31	MP0000750_abnormal_muscle_regeneration	1.74598127
32	MP0004742_abnormal_vestibular_system	1.72821514
33	MP0002557_abnormal_social/conspecific_i	1.71979431
34	MP0002063_abnormal_learning/memory/cond	1.71945378
35	MP0000955_abnormal_spinal_cord	1.71507964
36	MP0004133_heterotaxia	1.69853669
37	MP0008872_abnormal_physiological_respon	1.67712156
38	MP0004924_abnormal_behavior	1.67460706
39	MP0005386_behavior/neurological_phenoty	1.67460706
40	MP0002102_abnormal_ear_morphology	1.65030977
41	MP0002876_abnormal_thyroid_physiology	1.56946549
42	MP0006276_abnormal_autonomic_nervous	1.52073930
43	MP0001984_abnormal_olfaction	1.50433706
44	MP0002837_dystrophic_cardiac_calcinosis	1.50145814
45	MP0001529_abnormal_vocalization	1.48878236
46	MP0003011_delayed_dark_adaptation	1.48539977
47	MP0002736_abnormal_nociception_after	1.44718325
48	MP0003787_abnormal_imprinting	1.42105268
49	MP0003122_maternal_imprinting	1.40028963
50	MP0002184_abnormal_innervation	1.39507406
51	MP0002734_abnormal_mechanical_nocicepti	1.38606406
52	MP0006292_abnormal_olfactory_placode	1.35042328
53	MP0003283_abnormal_digestive_organ	1.27810723
54	MP0002882_abnormal_neuron_morphology	1.27427935
55	MP0002733_abnormal_thermal_nociception	1.24174484
56	MP0002254_reproductive_system_inflammat	1.23825656
57	MP0004134_abnormal_chest_morphology	1.23475106
58	MP0004270_analgesia	1.20634508
59	MP0008877_abnormal_DNA_methylation	1.19376148
60	MP0001970_abnormal_pain_threshold	1.15386485
61	MP0005410_abnormal_fertilization	1.09215731
62	MP0002752_abnormal_somatic_nervous	1.09183360
63	MP0002229_neurodegeneration	1.06606803
64	MP0001502_abnormal_circadian_rhythm	1.06461638
65	MP0003633_abnormal_nervous_system	1.04419574
66	MP0002095_abnormal_skin_pigmentation	1.04250332
67	MP0008875_abnormal_xenobiotic_pharmacok	1.03816847
68	MP0001440_abnormal_grooming_behavior	1.02851728
69	MP0004811_abnormal_neuron_physiology	1.01700960
70	MP0002066_abnormal_motor_capabilities/c	0.96166667
71	MP0005195_abnormal_posterior_eye	0.92570430
72	MP0003119_abnormal_digestive_system	0.90570225
73	MP0002751_abnormal_autonomic_nervous	0.87140765
74	MP0003879_abnormal_hair_cell	0.85304379
75	MP0002653_abnormal_ependyma_morphology	0.84223583
76	MP0002269_muscular_atrophy	0.81934594
77	MP0004043_abnormal_pH_regulation	0.81923879
78	MP0005174_abnormal_tail_pigmentation	0.81622715
79	MP0002152_abnormal_brain_morphology	0.81474042
80	MP0003631_nervous_system_phenotype	0.80613993
81	MP0009697_abnormal_copulation	0.77985621
82	MP0002909_abnormal_adrenal_gland	0.77957783
83	MP0000613_abnormal_salivary_gland	0.77168728
84	MP0003121_genomic_imprinting	0.73951783
85	MP0001485_abnormal_pinna_reflex	0.72839419
86	MP0001963_abnormal_hearing_physiology	0.72725599
87	MP0003698_abnormal_male_reproductive	0.72601777
88	MP0001177_atelectasis	0.72431953
89	MP0002928_abnormal_bile_duct	0.72128220
90	MP0000026_abnormal_inner_ear	0.70818721
91	MP0008569_lethality_at_weaning	0.68923951
92	MP0002638_abnormal_pupillary_reflex	0.68654068
93	MP0003252_abnormal_bile_duct	0.68314977
94	MP0004145_abnormal_muscle_electrophysio	0.67882714
95	MP0004885_abnormal_endolymph	0.67109452
96	MP0002090_abnormal_vision	0.66843214
97	MP0003861_abnormal_nervous_system	0.66342858
98	MP0003943_abnormal_hepatobiliary_system	0.66330906
99	MP0001943_abnormal_respiration	0.66000033
100	MP0005248_abnormal_Harderian_gland	0.64824109

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Type II lissencephaly (HP:0007260)	5.33488294
2	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	5.19666928
3	Hypokinesia (HP:0002375)	4.72578038
4	Focal motor seizures (HP:0011153)	4.29955476
5	Dyskinesia (HP:0100660)	4.19807760
6	Retinal dysplasia (HP:0007973)	4.19166782
7	Cerebellar dysplasia (HP:0007033)	3.89101782
8	Diminished movement (HP:0002374)	3.61233323
9	Chronic hepatic failure (HP:0100626)	3.38982816
10	Delayed gross motor development (HP:0002194)	3.32252690
11	Abnormality of midbrain morphology (HP:0002418)	3.28820581
12	Molar tooth sign on MRI (HP:0002419)	3.28820581
13	Agitation (HP:0000713)	3.17807880
14	Congenital stationary night blindness (HP:0007642)	3.14399262
15	Morphological abnormality of the pyramidal tract (HP:0002062)	3.11428042
16	Akinesia (HP:0002304)	3.11170047
17	Focal seizures (HP:0007359)	3.06125079
18	Severe muscular hypotonia (HP:0006829)	3.03825591
19	Optic nerve hypoplasia (HP:0000609)	3.03496538
20	Nephronophthisis (HP:0000090)	2.96406678
21	Hyperventilation (HP:0002883)	2.96346838
22	Postural instability (HP:0002172)	2.92401986
23	Pancreatic cysts (HP:0001737)	2.90196005
24	Lissencephaly (HP:0001339)	2.88559083
25	Amyotrophic lateral sclerosis (HP:0007354)	2.78141560
26	Pancreatic fibrosis (HP:0100732)	2.77898546
27	Thickened helices (HP:0000391)	2.71807950
28	Bradykinesia (HP:0002067)	2.66434950
29	Medial flaring of the eyebrow (HP:0010747)	2.64786427
30	Drooling (HP:0002307)	2.61376228
31	Hemiparesis (HP:0001269)	2.61366407
32	Gait imbalance (HP:0002141)	2.54312020
33	Abnormality of the renal medulla (HP:0100957)	2.54168471
34	Supranuclear gaze palsy (HP:0000605)	2.49647601
35	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.44956277
36	Inability to walk (HP:0002540)	2.42089231
37	Abnormality of alanine metabolism (HP:0010916)	2.40087395
38	Hyperalaninemia (HP:0003348)	2.40087395
39	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.40087395
40	Excessive salivation (HP:0003781)	2.38980982
41	Pendular nystagmus (HP:0012043)	2.34168622
42	Decreased circulating renin level (HP:0003351)	2.31918452
43	Anosmia (HP:0000458)	2.31576913
44	Congenital primary aphakia (HP:0007707)	2.24951015
45	Generalized tonic-clonic seizures (HP:0002069)	2.20410730
46	Polydipsia (HP:0001959)	2.14451520
47	Abnormal drinking behavior (HP:0030082)	2.14451520
48	Epileptic encephalopathy (HP:0200134)	2.12866906
49	Tubular atrophy (HP:0000092)	2.12799916
50	Hypoplasia of the pons (HP:0012110)	2.10163477
51	Rigidity (HP:0002063)	2.10035808
52	Muscular hypotonia of the trunk (HP:0008936)	2.09344846
53	Nephrogenic diabetes insipidus (HP:0009806)	2.09120605
54	Tachypnea (HP:0002789)	2.05084799
55	Febrile seizures (HP:0002373)	2.04430237
56	Polyphagia (HP:0002591)	2.03635645
57	Exotropia (HP:0000577)	2.00103745
58	Limb dystonia (HP:0002451)	11.3042143
59	Dialeptic seizures (HP:0011146)	1.99108220
60	Poor eye contact (HP:0000817)	1.98271591
61	Mask-like facies (HP:0000298)	1.95589979
62	Spastic tetraplegia (HP:0002510)	1.95359548
63	Gastroesophageal reflux (HP:0002020)	1.94692440
64	Abnormality of DNA repair (HP:0003254)	1.93378136
65	True hermaphroditism (HP:0010459)	1.89926417
66	Conjugated hyperbilirubinemia (HP:0002908)	1.89867920
67	Narrow forehead (HP:0000341)	1.82965525
68	Ketoacidosis (HP:0001993)	1.81894754
69	Renal dysplasia (HP:0000110)	1.79984748
70	Thyroiditis (HP:0100646)	1.79336653
71	Protruding tongue (HP:0010808)	1.77801988
72	Genital tract atresia (HP:0001827)	1.76229823
73	Cutaneous melanoma (HP:0012056)	1.75074718
74	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.74158029
75	Abnormality of macular pigmentation (HP:0008002)	1.72288983
76	Large eyes (HP:0001090)	1.71732077
77	Abnormality of the pons (HP:0007361)	1.71669537
78	Gaze-evoked nystagmus (HP:0000640)	1.69969103
79	Vaginal atresia (HP:0000148)	1.69349132
80	Dysdiadochokinesis (HP:0002075)	1.68509433
81	Hypothermia (HP:0002045)	1.67764792
82	Confusion (HP:0001289)	1.67662136
83	Anterior segment dysgenesis (HP:0007700)	1.66921342
84	Abnormality of the renal cortex (HP:0011035)	1.66705018
85	Specific learning disability (HP:0001328)	1.66646364
86	Hypogonadotrophic hypogonadism (HP:0000044)	1.65948936
87	Broad-based gait (HP:0002136)	1.65099027
88	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.64752871
89	Intestinal atresia (HP:0011100)	1.64635870
90	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.64523679
91	Myoclonus (HP:0001336)	1.64357351
92	Septo-optic dysplasia (HP:0100842)	1.63018602
93	Abnormality of the vitreous humor (HP:0004327)	1.61701461
94	Long nose (HP:0003189)	1.61640743
95	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.61469748
96	Congenital hepatic fibrosis (HP:0002612)	1.59889190
97	Generalized myoclonic seizures (HP:0002123)	1.59363046
98	Atonic seizures (HP:0010819)	1.58073473
99	Restlessness (HP:0000711)	1.56673335
100	Severe combined immunodeficiency (HP:0004430)	1.56622057

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PNCK	4.83938246
2	PINK1	3.80122569
3	MARK1	3.78053174
4	MAPKAPK5	3.74323337
5	DAPK2	2.92654820
6	GRK1	2.76560188
7	CSNK1G2	2.72792482
8	PAK3	2.68039109
9	CSNK1G3	2.54121961
10	BUB1	2.45268024
11	DYRK2	2.21424875
12	LATS1	2.10477207
13	CSNK1G1	2.09691689
14	WNK4	2.08408877
15	BCKDK	2.03279557
16	TNIK	1.95079185
17	EPHA4	1.94687159
18	BRAF	1.92917599
19	AKT3	1.86977588
20	CAMK1G	1.85945124
21	MAP3K12	1.82889043
22	CASK	1.76291301
23	NUAK1	1.58769694
24	NTRK2	1.49539343
25	WNK1	1.45775929
26	CAMK2B	1.41627410
27	ADRBK2	1.40229492
28	GRK5	1.36922105
29	MINK1	1.28125820
30	TAOK1	1.24728217
31	MAP3K4	1.18931885
32	RPS6KA5	1.18379821
33	CAMK2A	1.18101949
34	CAMK2D	1.16060479
35	PLK2	1.08889343
36	PRKCG	1.05598026
37	MAPK13	1.04951242
38	CSNK1A1L	1.02530034
39	WNK3	1.00989434
40	STK39	0.99457259
41	MAP2K4	0.95942637
42	OXSR1	0.95049084
43	BRD4	0.94366602
44	CAMK2G	0.93407792
45	BMPR1B	0.92678674
46	PHKG2	0.92592338
47	PHKG1	0.92592338
48	BCR	0.91888809
49	SGK494	0.91773981
50	SGK223	0.91773981
51	PAK6	0.88009385
52	FRK	0.84990186
53	PRKCE	0.84887486
54	DYRK1A	0.75349253
55	MAP2K7	0.74663332
56	MAP4K2	0.74623838
57	MST4	0.73161498
58	TAOK3	0.68555947
59	SGK2	0.68547817
60	PRKACB	0.67872532
61	PLK4	0.65395738
62	CDK5	0.63893166
63	ZAK	0.61102566
64	DYRK3	0.60790422
65	PTK6	0.60733246
66	ADRBK1	0.60634525
67	PDGFRA	0.56231252
68	MAP3K9	0.55845027
69	HIPK2	0.55065225
70	CSNK1A1	0.54785088
71	CDK14	0.49584376
72	CDK18	0.46973751
73	CSNK1D	0.46819944
74	CDK15	0.46421457
75	STK38L	0.45444004
76	PIK3CA	0.43659164
77	DYRK1B	0.41922588
78	TIE1	0.41210861
79	TESK2	0.40207481
80	EPHA3	0.40177852
81	PRKG1	0.39770870
82	STK3	0.39442787
83	INSRR	0.39412323
84	CSNK1E	0.37579907
85	CDK11A	0.37178187
86	FLT3	0.36825488
87	PRKACA	0.36773658
88	SGK1	0.36752142
89	LATS2	0.31873968
90	NEK6	0.30253750
91	NTRK3	0.29064209
92	RPS6KA3	0.28081016
93	CHUK	0.27185303
94	PTK2B	0.26915755
95	PRKCH	0.26728733
96	SGK3	0.25437897
97	KSR1	0.25174718
98	PRKACG	0.25161133
99	PRKCZ	0.22460134
100	ITK	0.20159426

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Cocaine addiction_Homo sapiens_hsa05030	3.76171872
2	Nicotine addiction_Homo sapiens_hsa05033	3.48130887
3	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.84682311
4	Nitrogen metabolism_Homo sapiens_hsa00910	2.79148245
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.71224796
6	Amphetamine addiction_Homo sapiens_hsa05031	2.68064749
7	Dopaminergic synapse_Homo sapiens_hsa04728	2.54758577
8	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.54728424
9	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.50780200
10	Parkinsons disease_Homo sapiens_hsa05012	2.40213542
11	Selenocompound metabolism_Homo sapiens_hsa00450	2.21286740
12	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	2.16426275
13	Collecting duct acid secretion_Homo sapiens_hsa04966	2.11502782
14	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.01492757
15	Oxidative phosphorylation_Homo sapiens_hsa00190	1.99617025
16	Cardiac muscle contraction_Homo sapiens_hsa04260	1.93108259
17	Morphine addiction_Homo sapiens_hsa05032	1.89611448
18	Phototransduction_Homo sapiens_hsa04744	1.84217491
19	Linoleic acid metabolism_Homo sapiens_hsa00591	1.79125143
20	GABAergic synapse_Homo sapiens_hsa04727	1.77585523
21	Long-term depression_Homo sapiens_hsa04730	1.77416958
22	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.75639127
23	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.67291237
24	Circadian entrainment_Homo sapiens_hsa04713	1.65930524
25	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.61697818
26	Insulin secretion_Homo sapiens_hsa04911	1.60089700
27	Serotonergic synapse_Homo sapiens_hsa04726	1.55273588
28	Glutamatergic synapse_Homo sapiens_hsa04724	1.52112766
29	Caffeine metabolism_Homo sapiens_hsa00232	1.47298807
30	Regulation of autophagy_Homo sapiens_hsa04140	1.43692048
31	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.37521675
32	Taste transduction_Homo sapiens_hsa04742	1.37448221
33	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.37168712
34	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.27039572
35	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.21348362
36	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.13556569
37	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.11739916
38	Axon guidance_Homo sapiens_hsa04360	1.08421711
39	Ether lipid metabolism_Homo sapiens_hsa00565	1.07171290
40	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.06108271
41	Olfactory transduction_Homo sapiens_hsa04740	1.06053474
42	Alcoholism_Homo sapiens_hsa05034	0.99845553
43	Protein export_Homo sapiens_hsa03060	0.99382863
44	Butanoate metabolism_Homo sapiens_hsa00650	0.96702151
45	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.95945413
46	Peroxisome_Homo sapiens_hsa04146	0.89066477
47	Tyrosine metabolism_Homo sapiens_hsa00350	0.88482703
48	Melanoma_Homo sapiens_hsa05218	0.87222796
49	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.86402935
50	Circadian rhythm_Homo sapiens_hsa04710	0.85058456
51	Huntingtons disease_Homo sapiens_hsa05016	0.84622156
52	Alzheimers disease_Homo sapiens_hsa05010	0.81672707
53	Sulfur metabolism_Homo sapiens_hsa00920	0.77527880
54	Salivary secretion_Homo sapiens_hsa04970	0.76279773
55	Folate biosynthesis_Homo sapiens_hsa00790	0.73132098
56	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.71877548
57	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.68759605
58	Cholinergic synapse_Homo sapiens_hsa04725	0.68598045
59	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.62049919
60	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.62028757
61	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.60022594
62	MAPK signaling pathway_Homo sapiens_hsa04010	0.59493003
63	Chemical carcinogenesis_Homo sapiens_hsa05204	0.54848856
64	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.54440626
65	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.54019564
66	Metabolic pathways_Homo sapiens_hsa01100	0.53611524
67	Ras signaling pathway_Homo sapiens_hsa04014	0.52884878
68	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.51881057
69	Glycerolipid metabolism_Homo sapiens_hsa00561	0.50445749
70	Steroid biosynthesis_Homo sapiens_hsa00100	0.49507113
71	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.47495487
72	Propanoate metabolism_Homo sapiens_hsa00640	0.46734663
73	Calcium signaling pathway_Homo sapiens_hsa04020	0.46166073
74	Fat digestion and absorption_Homo sapiens_hsa04975	0.45649754
75	Gap junction_Homo sapiens_hsa04540	0.45152982
76	Vibrio cholerae infection_Homo sapiens_hsa05110	0.44820434
77	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.43504508
78	Asthma_Homo sapiens_hsa05310	0.41972560
79	Prolactin signaling pathway_Homo sapiens_hsa04917	0.40802644
80	Fatty acid elongation_Homo sapiens_hsa00062	0.40148075
81	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.39087596
82	Tryptophan metabolism_Homo sapiens_hsa00380	0.38822416
83	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.38284973
84	Primary immunodeficiency_Homo sapiens_hsa05340	0.38050456
85	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.37781172
86	Gastric acid secretion_Homo sapiens_hsa04971	0.34731779
87	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.34559385
88	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.33474779
89	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.33413567
90	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.30917071
91	cAMP signaling pathway_Homo sapiens_hsa04024	0.29458930
92	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.28295452
93	Tight junction_Homo sapiens_hsa04530	0.28150865
94	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.25840519
95	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.24132145
96	GnRH signaling pathway_Homo sapiens_hsa04912	0.22972984
97	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.22636323
98	Lysine degradation_Homo sapiens_hsa00310	0.22443819
99	Basal transcription factors_Homo sapiens_hsa03022	0.21101028
100	Glutathione metabolism_Homo sapiens_hsa00480	0.20479668

MRPS21P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »