MRPS21P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1dopamine biosynthetic process (GO:0042416)9.06615423
2catecholamine transport (GO:0051937)7.44770887
3prepulse inhibition (GO:0060134)6.86593876
4phenol-containing compound catabolic process (GO:0019336)6.86132032
5catecholamine biosynthetic process (GO:0042423)5.65044609
6catechol-containing compound biosynthetic process (GO:0009713)5.65044609
7fucose catabolic process (GO:0019317)5.60361342
8L-fucose metabolic process (GO:0042354)5.60361342
9L-fucose catabolic process (GO:0042355)5.60361342
10neurotransmitter biosynthetic process (GO:0042136)5.52343006
11alkaloid metabolic process (GO:0009820)5.43292735
12cellular response to nicotine (GO:0071316)5.09620144
13response to xenobiotic stimulus (GO:0009410)5.09303088
14mating behavior (GO:0007617)4.45693350
15synaptic transmission, dopaminergic (GO:0001963)4.41789461
16neuronal action potential (GO:0019228)4.40674867
17protein polyglutamylation (GO:0018095)4.36734491
18tyrosine metabolic process (GO:0006570)4.33733991
19monoamine transport (GO:0015844)4.32697736
20norepinephrine metabolic process (GO:0042415)4.32423112
21neurofilament cytoskeleton organization (GO:0060052)4.31885026
22neurotransmitter metabolic process (GO:0042133)4.13958975
23tyrosine phosphorylation of STAT protein (GO:0007260)3.99942719
24response to manganese ion (GO:0010042)3.94548569
25mechanosensory behavior (GO:0007638)3.92471168
26serotonin metabolic process (GO:0042428)3.85124074
27dopamine metabolic process (GO:0042417)3.83964193
28response to amphetamine (GO:0001975)3.80592992
29negative regulation of neurotransmitter transport (GO:0051589)3.79426514
30pyrimidine nucleobase catabolic process (GO:0006208)3.78418607
31membrane depolarization during action potential (GO:0086010)3.77772780
32response to insecticide (GO:0017085)3.77066010
33glycine transport (GO:0015816)3.73548024
34response to cocaine (GO:0042220)3.71616087
35ovulation cycle (GO:0042698)3.71504988
36cysteine metabolic process (GO:0006534)3.67203412
37cell migration in hindbrain (GO:0021535)3.63014777
38toxin metabolic process (GO:0009404)3.57331223
39negative regulation of T cell differentiation in thymus (GO:0033085)3.52914182
40response to nitrosative stress (GO:0051409)3.51608927
41phenol-containing compound biosynthetic process (GO:0046189)3.50705730
42auditory behavior (GO:0031223)3.48051828
43regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.46345157
44RNA localization (GO:0006403)3.45937273
45inositol phosphate catabolic process (GO:0071545)3.45782574
46embryonic body morphogenesis (GO:0010172)3.45377877
47phosphorylated carbohydrate dephosphorylation (GO:0046838)3.42451467
48inositol phosphate dephosphorylation (GO:0046855)3.42451467
49primary amino compound metabolic process (GO:1901160)3.41588756
50response to pheromone (GO:0019236)3.38817440
51heparin biosynthetic process (GO:0030210)3.36956715
52heparin metabolic process (GO:0030202)3.36956715
53response to water (GO:0009415)3.36591540
54regulation of synaptic vesicle transport (GO:1902803)3.32911891
55gamma-aminobutyric acid transport (GO:0015812)3.29985467
56regulation of dopamine metabolic process (GO:0042053)3.29265958
57regulation of catecholamine metabolic process (GO:0042069)3.29265958
58positive regulation of neurological system process (GO:0031646)3.22401914
59response to nicotine (GO:0035094)3.20079158
60neurotransmitter transport (GO:0006836)3.19994146
61neuromuscular synaptic transmission (GO:0007274)3.19827568
62regulation of synapse structural plasticity (GO:0051823)3.19488512
63photoreceptor cell development (GO:0042461)3.18290534
64behavioral response to nicotine (GO:0035095)3.17984530
65embryonic retina morphogenesis in camera-type eye (GO:0060059)3.15630546
66retinal cone cell development (GO:0046549)3.15208728
67nucleobase catabolic process (GO:0046113)3.14274175
68eye photoreceptor cell development (GO:0042462)3.12511651
69protein localization to cilium (GO:0061512)3.12432011
70startle response (GO:0001964)3.10825210
71body morphogenesis (GO:0010171)2.98374797
72catechol-containing compound metabolic process (GO:0009712)2.98316418
73catecholamine metabolic process (GO:0006584)2.98316418
74negative regulation of Rho protein signal transduction (GO:0035024)2.96748913
75benzene-containing compound metabolic process (GO:0042537)2.94828244
76neuron cell-cell adhesion (GO:0007158)2.93705251
77synaptic transmission, cholinergic (GO:0007271)2.90560289
78neuron-neuron synaptic transmission (GO:0007270)2.89545986
79negative regulation of synaptic transmission, GABAergic (GO:0032229)2.88927098
80regulation of neurotransmitter levels (GO:0001505)2.88833284
81neuronal action potential propagation (GO:0019227)2.83845674
82fucosylation (GO:0036065)2.83561539
83positive regulation of gastrulation (GO:2000543)2.80905428
84response to corticosterone (GO:0051412)2.80681604
85axonal fasciculation (GO:0007413)2.78227156
86sensory perception of smell (GO:0007608)2.77524268
87dendritic spine morphogenesis (GO:0060997)2.77354655
88establishment of mitochondrion localization (GO:0051654)2.75719958
89positive regulation of mitochondrial fission (GO:0090141)2.73785901
90protein-cofactor linkage (GO:0018065)2.72350673
91regulation of microtubule-based movement (GO:0060632)2.71789359
92synapse assembly (GO:0007416)2.71766682
93neurotransmitter secretion (GO:0007269)2.69175639
94synaptic transmission, glutamatergic (GO:0035249)2.66886192
95negative regulation of macrophage differentiation (GO:0045650)2.65528769
96polyol catabolic process (GO:0046174)2.64051273
97single strand break repair (GO:0000012)2.63833379
98calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.63544792
99negative regulation of cytosolic calcium ion concentration (GO:0051481)2.63223953
100dopamine transport (GO:0015872)10.3246271

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IGF1R_20145208_ChIP-Seq_DFB_Human3.93258491
2GBX2_23144817_ChIP-Seq_PC3_Human3.89144286
3EZH2_22144423_ChIP-Seq_EOC_Human3.86737112
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.18526897
5ZNF274_21170338_ChIP-Seq_K562_Hela3.13363698
6TAF15_26573619_Chip-Seq_HEK293_Human2.87532240
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.77176037
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.76203806
9CTBP1_25329375_ChIP-Seq_LNCAP_Human2.59413276
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.53892755
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.47868869
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.42403265
13CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.40695815
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.17398967
15CBX2_27304074_Chip-Seq_ESCs_Mouse2.03510635
16REST_21632747_ChIP-Seq_MESCs_Mouse1.94487960
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.94371382
18VDR_22108803_ChIP-Seq_LS180_Human1.91148120
19FUS_26573619_Chip-Seq_HEK293_Human1.84055830
20SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.79744929
21P300_19829295_ChIP-Seq_ESCs_Human1.78498487
22STAT3_23295773_ChIP-Seq_U87_Human1.69127075
23SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.68216824
24JARID2_20064375_ChIP-Seq_MESCs_Mouse1.65958425
25REST_18959480_ChIP-ChIP_MESCs_Mouse1.65892084
26TOP2B_26459242_ChIP-Seq_MCF-7_Human1.64790536
27RNF2_27304074_Chip-Seq_NSC_Mouse1.62052353
28RBPJ_22232070_ChIP-Seq_NCS_Mouse1.61872182
29AR_21572438_ChIP-Seq_LNCaP_Human1.61300718
30AR_25329375_ChIP-Seq_VCAP_Human1.58894317
31SMAD4_21799915_ChIP-Seq_A2780_Human1.58700597
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56701857
33CBP_20019798_ChIP-Seq_JUKART_Human1.53015426
34IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53015426
35EZH2_27304074_Chip-Seq_ESCs_Mouse1.51862126
36SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.45391750
37SUZ12_27294783_Chip-Seq_ESCs_Mouse1.43853685
38TCF4_23295773_ChIP-Seq_U87_Human1.43486502
39SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.43037277
40SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42897579
41ER_23166858_ChIP-Seq_MCF-7_Human1.42638578
42JARID2_20075857_ChIP-Seq_MESCs_Mouse1.41698224
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.41651786
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.41405229
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.41190301
46SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.40731469
47CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.39761676
48EZH2_27294783_Chip-Seq_ESCs_Mouse1.38542991
49EWS_26573619_Chip-Seq_HEK293_Human1.38433977
50EED_16625203_ChIP-ChIP_MESCs_Mouse1.38245509
51AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37305535
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.36517122
53KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.36452809
54TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36297730
55MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35784243
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.31194294
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28295701
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27564076
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26645606
60SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.25074207
61MTF2_20144788_ChIP-Seq_MESCs_Mouse1.24452136
62HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.24340222
63IRF1_19129219_ChIP-ChIP_H3396_Human1.22781046
64DROSHA_22980978_ChIP-Seq_HELA_Human1.21774658
65CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.21712320
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20542910
67OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19021203
68FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17879988
69FOXA1_25329375_ChIP-Seq_VCAP_Human1.17879988
70RUNX2_22187159_ChIP-Seq_PCA_Human1.16893151
71SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.16225974
72EZH2_18974828_ChIP-Seq_MESCs_Mouse1.14948733
73RNF2_18974828_ChIP-Seq_MESCs_Mouse1.14948733
74SOX2_21211035_ChIP-Seq_LN229_Gbm1.14370835
75NOTCH1_21737748_ChIP-Seq_TLL_Human1.14173333
76FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.13885146
77MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13741721
78FLI1_21867929_ChIP-Seq_TH2_Mouse1.12665971
79TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12470501
80ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11203171
81BCAT_22108803_ChIP-Seq_LS180_Human1.10893769
82FLI1_27457419_Chip-Seq_LIVER_Mouse1.10762525
83WDR5_24793694_ChIP-Seq_LNCAP_Human1.10336598
84TP53_22573176_ChIP-Seq_HFKS_Human1.10309874
85CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08248120
86PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.07632938
87PRDM14_20953172_ChIP-Seq_ESCs_Human1.07252150
88LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06992236
89NANOG_18555785_Chip-Seq_ESCs_Mouse1.06321217
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06193155
91TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04455221
92TAL1_26923725_Chip-Seq_HPCs_Mouse1.04412969
93EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04073902
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03566399
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03566399
96NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01705052
97TCF4_22108803_ChIP-Seq_LS180_Human1.00624005
98POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00419847
99RXR_22108803_ChIP-Seq_LS180_Human0.98009967
100GATA3_21878914_ChIP-Seq_MCF-7_Human0.95797514

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009046_muscle_twitch4.09755169
2MP0001986_abnormal_taste_sensitivity3.53575135
3MP0005423_abnormal_somatic_nervous3.20616830
4MP0001905_abnormal_dopamine_level3.18553595
5MP0003880_abnormal_central_pattern2.99604062
6MP0001188_hyperpigmentation2.99114489
7MP0005646_abnormal_pituitary_gland2.68170963
8MP0001968_abnormal_touch/_nociception2.44687078
9MP0005187_abnormal_penis_morphology2.42036607
10MP0009379_abnormal_foot_pigmentation2.33739844
11MP0002272_abnormal_nervous_system2.31004746
12MP0000569_abnormal_digit_pigmentation2.30173334
13MP0009745_abnormal_behavioral_response2.27575492
14MP0003890_abnormal_embryonic-extraembry2.27192286
15MP0003635_abnormal_synaptic_transmissio2.25139661
16MP0000631_abnormal_neuroendocrine_gland2.18624875
17MP0004142_abnormal_muscle_tone2.18539889
18MP0006072_abnormal_retinal_apoptosis2.12939809
19MP0005645_abnormal_hypothalamus_physiol2.11230005
20MP0002735_abnormal_chemical_nociception2.10414407
21MP0004859_abnormal_synaptic_plasticity2.10001603
22MP0003315_abnormal_perineum_morphology2.02792466
23MP0000778_abnormal_nervous_system2.01610645
24MP0002822_catalepsy1.95129686
25MP0002064_seizures1.94020330
26MP0005551_abnormal_eye_electrophysiolog1.90402699
27MP0002572_abnormal_emotion/affect_behav1.80096261
28MP0002067_abnormal_sensory_capabilities1.79575427
29MP0001486_abnormal_startle_reflex1.76554293
30MP0005253_abnormal_eye_physiology1.75414304
31MP0000750_abnormal_muscle_regeneration1.74598127
32MP0004742_abnormal_vestibular_system1.72821514
33MP0002557_abnormal_social/conspecific_i1.71979431
34MP0002063_abnormal_learning/memory/cond1.71945378
35MP0000955_abnormal_spinal_cord1.71507964
36MP0004133_heterotaxia1.69853669
37MP0008872_abnormal_physiological_respon1.67712156
38MP0004924_abnormal_behavior1.67460706
39MP0005386_behavior/neurological_phenoty1.67460706
40MP0002102_abnormal_ear_morphology1.65030977
41MP0002876_abnormal_thyroid_physiology1.56946549
42MP0006276_abnormal_autonomic_nervous1.52073930
43MP0001984_abnormal_olfaction1.50433706
44MP0002837_dystrophic_cardiac_calcinosis1.50145814
45MP0001529_abnormal_vocalization1.48878236
46MP0003011_delayed_dark_adaptation1.48539977
47MP0002736_abnormal_nociception_after1.44718325
48MP0003787_abnormal_imprinting1.42105268
49MP0003122_maternal_imprinting1.40028963
50MP0002184_abnormal_innervation1.39507406
51MP0002734_abnormal_mechanical_nocicepti1.38606406
52MP0006292_abnormal_olfactory_placode1.35042328
53MP0003283_abnormal_digestive_organ1.27810723
54MP0002882_abnormal_neuron_morphology1.27427935
55MP0002733_abnormal_thermal_nociception1.24174484
56MP0002254_reproductive_system_inflammat1.23825656
57MP0004134_abnormal_chest_morphology1.23475106
58MP0004270_analgesia1.20634508
59MP0008877_abnormal_DNA_methylation1.19376148
60MP0001970_abnormal_pain_threshold1.15386485
61MP0005410_abnormal_fertilization1.09215731
62MP0002752_abnormal_somatic_nervous1.09183360
63MP0002229_neurodegeneration1.06606803
64MP0001502_abnormal_circadian_rhythm1.06461638
65MP0003633_abnormal_nervous_system1.04419574
66MP0002095_abnormal_skin_pigmentation1.04250332
67MP0008875_abnormal_xenobiotic_pharmacok1.03816847
68MP0001440_abnormal_grooming_behavior1.02851728
69MP0004811_abnormal_neuron_physiology1.01700960
70MP0002066_abnormal_motor_capabilities/c0.96166667
71MP0005195_abnormal_posterior_eye0.92570430
72MP0003119_abnormal_digestive_system0.90570225
73MP0002751_abnormal_autonomic_nervous0.87140765
74MP0003879_abnormal_hair_cell0.85304379
75MP0002653_abnormal_ependyma_morphology0.84223583
76MP0002269_muscular_atrophy0.81934594
77MP0004043_abnormal_pH_regulation0.81923879
78MP0005174_abnormal_tail_pigmentation0.81622715
79MP0002152_abnormal_brain_morphology0.81474042
80MP0003631_nervous_system_phenotype0.80613993
81MP0009697_abnormal_copulation0.77985621
82MP0002909_abnormal_adrenal_gland0.77957783
83MP0000613_abnormal_salivary_gland0.77168728
84MP0003121_genomic_imprinting0.73951783
85MP0001485_abnormal_pinna_reflex0.72839419
86MP0001963_abnormal_hearing_physiology0.72725599
87MP0003698_abnormal_male_reproductive0.72601777
88MP0001177_atelectasis0.72431953
89MP0002928_abnormal_bile_duct0.72128220
90MP0000026_abnormal_inner_ear0.70818721
91MP0008569_lethality_at_weaning0.68923951
92MP0002638_abnormal_pupillary_reflex0.68654068
93MP0003252_abnormal_bile_duct0.68314977
94MP0004145_abnormal_muscle_electrophysio0.67882714
95MP0004885_abnormal_endolymph0.67109452
96MP0002090_abnormal_vision0.66843214
97MP0003861_abnormal_nervous_system0.66342858
98MP0003943_abnormal_hepatobiliary_system0.66330906
99MP0001943_abnormal_respiration0.66000033
100MP0005248_abnormal_Harderian_gland0.64824109

Predicted human phenotypes

RankGene SetZ-score
1Type II lissencephaly (HP:0007260)5.33488294
2Parkinsonism with favorable response to dopaminergic medication (HP:0002548)5.19666928
3Hypokinesia (HP:0002375)4.72578038
4Focal motor seizures (HP:0011153)4.29955476
5Dyskinesia (HP:0100660)4.19807760
6Retinal dysplasia (HP:0007973)4.19166782
7Cerebellar dysplasia (HP:0007033)3.89101782
8Diminished movement (HP:0002374)3.61233323
9Chronic hepatic failure (HP:0100626)3.38982816
10Delayed gross motor development (HP:0002194)3.32252690
11Abnormality of midbrain morphology (HP:0002418)3.28820581
12Molar tooth sign on MRI (HP:0002419)3.28820581
13Agitation (HP:0000713)3.17807880
14Congenital stationary night blindness (HP:0007642)3.14399262
15Morphological abnormality of the pyramidal tract (HP:0002062)3.11428042
16Akinesia (HP:0002304)3.11170047
17Focal seizures (HP:0007359)3.06125079
18Severe muscular hypotonia (HP:0006829)3.03825591
19Optic nerve hypoplasia (HP:0000609)3.03496538
20Nephronophthisis (HP:0000090)2.96406678
21Hyperventilation (HP:0002883)2.96346838
22Postural instability (HP:0002172)2.92401986
23Pancreatic cysts (HP:0001737)2.90196005
24Lissencephaly (HP:0001339)2.88559083
25Amyotrophic lateral sclerosis (HP:0007354)2.78141560
26Pancreatic fibrosis (HP:0100732)2.77898546
27Thickened helices (HP:0000391)2.71807950
28Bradykinesia (HP:0002067)2.66434950
29Medial flaring of the eyebrow (HP:0010747)2.64786427
30Drooling (HP:0002307)2.61376228
31Hemiparesis (HP:0001269)2.61366407
32Gait imbalance (HP:0002141)2.54312020
33Abnormality of the renal medulla (HP:0100957)2.54168471
34Supranuclear gaze palsy (HP:0000605)2.49647601
35Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.44956277
36Inability to walk (HP:0002540)2.42089231
37Abnormality of alanine metabolism (HP:0010916)2.40087395
38Hyperalaninemia (HP:0003348)2.40087395
39Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.40087395
40Excessive salivation (HP:0003781)2.38980982
41Pendular nystagmus (HP:0012043)2.34168622
42Decreased circulating renin level (HP:0003351)2.31918452
43Anosmia (HP:0000458)2.31576913
44Congenital primary aphakia (HP:0007707)2.24951015
45Generalized tonic-clonic seizures (HP:0002069)2.20410730
46Polydipsia (HP:0001959)2.14451520
47Abnormal drinking behavior (HP:0030082)2.14451520
48Epileptic encephalopathy (HP:0200134)2.12866906
49Tubular atrophy (HP:0000092)2.12799916
50Hypoplasia of the pons (HP:0012110)2.10163477
51Rigidity (HP:0002063)2.10035808
52Muscular hypotonia of the trunk (HP:0008936)2.09344846
53Nephrogenic diabetes insipidus (HP:0009806)2.09120605
54Tachypnea (HP:0002789)2.05084799
55Febrile seizures (HP:0002373)2.04430237
56Polyphagia (HP:0002591)2.03635645
57Exotropia (HP:0000577)2.00103745
58Limb dystonia (HP:0002451)11.3042143
59Dialeptic seizures (HP:0011146)1.99108220
60Poor eye contact (HP:0000817)1.98271591
61Mask-like facies (HP:0000298)1.95589979
62Spastic tetraplegia (HP:0002510)1.95359548
63Gastroesophageal reflux (HP:0002020)1.94692440
64Abnormality of DNA repair (HP:0003254)1.93378136
65True hermaphroditism (HP:0010459)1.89926417
66Conjugated hyperbilirubinemia (HP:0002908)1.89867920
67Narrow forehead (HP:0000341)1.82965525
68Ketoacidosis (HP:0001993)1.81894754
69Renal dysplasia (HP:0000110)1.79984748
70Thyroiditis (HP:0100646)1.79336653
71Protruding tongue (HP:0010808)1.77801988
72Genital tract atresia (HP:0001827)1.76229823
73Cutaneous melanoma (HP:0012056)1.75074718
74Atrophy/Degeneration involving motor neurons (HP:0007373)1.74158029
75Abnormality of macular pigmentation (HP:0008002)1.72288983
76Large eyes (HP:0001090)1.71732077
77Abnormality of the pons (HP:0007361)1.71669537
78Gaze-evoked nystagmus (HP:0000640)1.69969103
79Vaginal atresia (HP:0000148)1.69349132
80Dysdiadochokinesis (HP:0002075)1.68509433
81Hypothermia (HP:0002045)1.67764792
82Confusion (HP:0001289)1.67662136
83Anterior segment dysgenesis (HP:0007700)1.66921342
84Abnormality of the renal cortex (HP:0011035)1.66705018
85Specific learning disability (HP:0001328)1.66646364
86Hypogonadotrophic hypogonadism (HP:0000044)1.65948936
87Broad-based gait (HP:0002136)1.65099027
88Aplasia/Hypoplasia of the spleen (HP:0010451)1.64752871
89Intestinal atresia (HP:0011100)1.64635870
90Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.64523679
91Myoclonus (HP:0001336)1.64357351
92Septo-optic dysplasia (HP:0100842)1.63018602
93Abnormality of the vitreous humor (HP:0004327)1.61701461
94Long nose (HP:0003189)1.61640743
95Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.61469748
96Congenital hepatic fibrosis (HP:0002612)1.59889190
97Generalized myoclonic seizures (HP:0002123)1.59363046
98Atonic seizures (HP:0010819)1.58073473
99Restlessness (HP:0000711)1.56673335
100Severe combined immunodeficiency (HP:0004430)1.56622057

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK4.83938246
2PINK13.80122569
3MARK13.78053174
4MAPKAPK53.74323337
5DAPK22.92654820
6GRK12.76560188
7CSNK1G22.72792482
8PAK32.68039109
9CSNK1G32.54121961
10BUB12.45268024
11DYRK22.21424875
12LATS12.10477207
13CSNK1G12.09691689
14WNK42.08408877
15BCKDK2.03279557
16TNIK1.95079185
17EPHA41.94687159
18BRAF1.92917599
19AKT31.86977588
20CAMK1G1.85945124
21MAP3K121.82889043
22CASK1.76291301
23NUAK11.58769694
24NTRK21.49539343
25WNK11.45775929
26CAMK2B1.41627410
27ADRBK21.40229492
28GRK51.36922105
29MINK11.28125820
30TAOK11.24728217
31MAP3K41.18931885
32RPS6KA51.18379821
33CAMK2A1.18101949
34CAMK2D1.16060479
35PLK21.08889343
36PRKCG1.05598026
37MAPK131.04951242
38CSNK1A1L1.02530034
39WNK31.00989434
40STK390.99457259
41MAP2K40.95942637
42OXSR10.95049084
43BRD40.94366602
44CAMK2G0.93407792
45BMPR1B0.92678674
46PHKG20.92592338
47PHKG10.92592338
48BCR0.91888809
49SGK4940.91773981
50SGK2230.91773981
51PAK60.88009385
52FRK0.84990186
53PRKCE0.84887486
54DYRK1A0.75349253
55MAP2K70.74663332
56MAP4K20.74623838
57MST40.73161498
58TAOK30.68555947
59SGK20.68547817
60PRKACB0.67872532
61PLK40.65395738
62CDK50.63893166
63ZAK0.61102566
64DYRK30.60790422
65PTK60.60733246
66ADRBK10.60634525
67PDGFRA0.56231252
68MAP3K90.55845027
69HIPK20.55065225
70CSNK1A10.54785088
71CDK140.49584376
72CDK180.46973751
73CSNK1D0.46819944
74CDK150.46421457
75STK38L0.45444004
76PIK3CA0.43659164
77DYRK1B0.41922588
78TIE10.41210861
79TESK20.40207481
80EPHA30.40177852
81PRKG10.39770870
82STK30.39442787
83INSRR0.39412323
84CSNK1E0.37579907
85CDK11A0.37178187
86FLT30.36825488
87PRKACA0.36773658
88SGK10.36752142
89LATS20.31873968
90NEK60.30253750
91NTRK30.29064209
92RPS6KA30.28081016
93CHUK0.27185303
94PTK2B0.26915755
95PRKCH0.26728733
96SGK30.25437897
97KSR10.25174718
98PRKACG0.25161133
99PRKCZ0.22460134
100ITK0.20159426

Predicted pathways (KEGG)

RankGene SetZ-score
1Cocaine addiction_Homo sapiens_hsa050303.76171872
2Nicotine addiction_Homo sapiens_hsa050333.48130887
3Synaptic vesicle cycle_Homo sapiens_hsa047212.84682311
4Nitrogen metabolism_Homo sapiens_hsa009102.79148245
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.71224796
6Amphetamine addiction_Homo sapiens_hsa050312.68064749
7Dopaminergic synapse_Homo sapiens_hsa047282.54758577
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.54728424
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.50780200
10Parkinsons disease_Homo sapiens_hsa050122.40213542
11Selenocompound metabolism_Homo sapiens_hsa004502.21286740
12Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.16426275
13Collecting duct acid secretion_Homo sapiens_hsa049662.11502782
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.01492757
15Oxidative phosphorylation_Homo sapiens_hsa001901.99617025
16Cardiac muscle contraction_Homo sapiens_hsa042601.93108259
17Morphine addiction_Homo sapiens_hsa050321.89611448
18Phototransduction_Homo sapiens_hsa047441.84217491
19Linoleic acid metabolism_Homo sapiens_hsa005911.79125143
20GABAergic synapse_Homo sapiens_hsa047271.77585523
21Long-term depression_Homo sapiens_hsa047301.77416958
22Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.75639127
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.67291237
24Circadian entrainment_Homo sapiens_hsa047131.65930524
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.61697818
26Insulin secretion_Homo sapiens_hsa049111.60089700
27Serotonergic synapse_Homo sapiens_hsa047261.55273588
28Glutamatergic synapse_Homo sapiens_hsa047241.52112766
29Caffeine metabolism_Homo sapiens_hsa002321.47298807
30Regulation of autophagy_Homo sapiens_hsa041401.43692048
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.37521675
32Taste transduction_Homo sapiens_hsa047421.37448221
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.37168712
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27039572
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21348362
36Fatty acid biosynthesis_Homo sapiens_hsa000611.13556569
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11739916
38Axon guidance_Homo sapiens_hsa043601.08421711
39Ether lipid metabolism_Homo sapiens_hsa005651.07171290
40Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.06108271
41Olfactory transduction_Homo sapiens_hsa047401.06053474
42Alcoholism_Homo sapiens_hsa050340.99845553
43Protein export_Homo sapiens_hsa030600.99382863
44Butanoate metabolism_Homo sapiens_hsa006500.96702151
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.95945413
46Peroxisome_Homo sapiens_hsa041460.89066477
47Tyrosine metabolism_Homo sapiens_hsa003500.88482703
48Melanoma_Homo sapiens_hsa052180.87222796
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.86402935
50Circadian rhythm_Homo sapiens_hsa047100.85058456
51Huntingtons disease_Homo sapiens_hsa050160.84622156
52Alzheimers disease_Homo sapiens_hsa050100.81672707
53Sulfur metabolism_Homo sapiens_hsa009200.77527880
54Salivary secretion_Homo sapiens_hsa049700.76279773
55Folate biosynthesis_Homo sapiens_hsa007900.73132098
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.71877548
57Oxytocin signaling pathway_Homo sapiens_hsa049210.68759605
58Cholinergic synapse_Homo sapiens_hsa047250.68598045
59Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.62049919
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62028757
61Dorso-ventral axis formation_Homo sapiens_hsa043200.60022594
62MAPK signaling pathway_Homo sapiens_hsa040100.59493003
63Chemical carcinogenesis_Homo sapiens_hsa052040.54848856
64Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54440626
65Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.54019564
66Metabolic pathways_Homo sapiens_hsa011000.53611524
67Ras signaling pathway_Homo sapiens_hsa040140.52884878
68Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51881057
69Glycerolipid metabolism_Homo sapiens_hsa005610.50445749
70Steroid biosynthesis_Homo sapiens_hsa001000.49507113
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.47495487
72Propanoate metabolism_Homo sapiens_hsa006400.46734663
73Calcium signaling pathway_Homo sapiens_hsa040200.46166073
74Fat digestion and absorption_Homo sapiens_hsa049750.45649754
75Gap junction_Homo sapiens_hsa045400.45152982
76Vibrio cholerae infection_Homo sapiens_hsa051100.44820434
77Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43504508
78Asthma_Homo sapiens_hsa053100.41972560
79Prolactin signaling pathway_Homo sapiens_hsa049170.40802644
80Fatty acid elongation_Homo sapiens_hsa000620.40148075
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39087596
82Tryptophan metabolism_Homo sapiens_hsa003800.38822416
83Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38284973
84Primary immunodeficiency_Homo sapiens_hsa053400.38050456
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.37781172
86Gastric acid secretion_Homo sapiens_hsa049710.34731779
87Arachidonic acid metabolism_Homo sapiens_hsa005900.34559385
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33474779
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33413567
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.30917071
91cAMP signaling pathway_Homo sapiens_hsa040240.29458930
92Aldosterone synthesis and secretion_Homo sapiens_hsa049250.28295452
93Tight junction_Homo sapiens_hsa045300.28150865
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.25840519
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.24132145
96GnRH signaling pathway_Homo sapiens_hsa049120.22972984
97Ovarian steroidogenesis_Homo sapiens_hsa049130.22636323
98Lysine degradation_Homo sapiens_hsa003100.22443819
99Basal transcription factors_Homo sapiens_hsa030220.21101028
100Glutathione metabolism_Homo sapiens_hsa004800.20479668

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