MRPS21P7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1head development (GO:0060322)7.08169279
2protein-cofactor linkage (GO:0018065)6.18585604
3kinetochore organization (GO:0051383)5.31757793
4behavioral response to nicotine (GO:0035095)4.72158844
5response to pheromone (GO:0019236)4.64709089
6protein K6-linked ubiquitination (GO:0085020)4.57415987
7microtubule depolymerization (GO:0007019)4.48611893
8cellular response to follicle-stimulating hormone stimulus (GO:0071372)4.33083073
9detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.26390824
10monoubiquitinated protein deubiquitination (GO:0035520)4.09416970
11nucleobase biosynthetic process (GO:0046112)4.05690189
12kinetochore assembly (GO:0051382)3.96048401
13purine nucleobase biosynthetic process (GO:0009113)3.92311569
14response to nitrosative stress (GO:0051409)3.75214755
15cullin deneddylation (GO:0010388)3.72553305
16lateral sprouting from an epithelium (GO:0060601)3.67422845
17limb bud formation (GO:0060174)3.66317519
18synaptic transmission, cholinergic (GO:0007271)3.57506330
19negative regulation of axon extension involved in axon guidance (GO:0048843)3.55776468
20fibroblast migration (GO:0010761)3.55484092
21cornea development in camera-type eye (GO:0061303)3.53828491
22DNA topological change (GO:0006265)3.52693302
23N-terminal protein amino acid modification (GO:0031365)3.52498289
24cellular response to gamma radiation (GO:0071480)3.48096262
25histone H2A acetylation (GO:0043968)3.47650682
26microtubule polymerization or depolymerization (GO:0031109)3.44107135
27mesenchymal-epithelial cell signaling (GO:0060638)3.44000740
28response to follicle-stimulating hormone (GO:0032354)3.42064120
29chromatin remodeling at centromere (GO:0031055)3.39386038
30respiratory chain complex IV assembly (GO:0008535)3.39019996
31tongue development (GO:0043586)3.37986186
32protein deneddylation (GO:0000338)3.33799018
33CENP-A containing nucleosome assembly (GO:0034080)3.26757695
34dermatan sulfate biosynthetic process (GO:0030208)3.26183796
35short-term memory (GO:0007614)3.19555928
36regulation of guanylate cyclase activity (GO:0031282)3.18659307
37negative regulation of axon guidance (GO:1902668)3.17713671
38centriole replication (GO:0007099)3.17163353
39thalamus development (GO:0021794)3.11670219
40hindbrain development (GO:0030902)3.11022643
41arginine catabolic process (GO:0006527)3.08359790
42meiotic chromosome segregation (GO:0045132)3.05575947
43positive regulation of guanylate cyclase activity (GO:0031284)2.99866935
44fatty acid elongation (GO:0030497)2.96590602
45pituitary gland development (GO:0021983)2.95751881
46prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.95253078
47protein localization to cilium (GO:0061512)2.94817302
48regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.93515379
49DNA ligation (GO:0006266)2.92998827
50positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.92332397
51positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.92332397
52positive regulation of mitotic sister chromatid separation (GO:1901970)2.92332397
53pyrimidine nucleobase catabolic process (GO:0006208)2.89757318
54platelet dense granule organization (GO:0060155)2.85193955
55olfactory bulb development (GO:0021772)2.84972328
56retinal ganglion cell axon guidance (GO:0031290)2.82508428
57positive regulation of glomerulus development (GO:0090193)2.81355124
58neural tube formation (GO:0001841)2.79542243
59transmission of nerve impulse (GO:0019226)2.77282395
60regulation of sister chromatid cohesion (GO:0007063)2.77081783
61positive regulation of T cell differentiation in thymus (GO:0033089)2.76488842
62dermatan sulfate metabolic process (GO:0030205)2.74494254
63long-chain fatty acid biosynthetic process (GO:0042759)2.73646067
64mitotic metaphase plate congression (GO:0007080)2.72760845
65startle response (GO:0001964)2.72723538
66GMP metabolic process (GO:0046037)2.68466049
67peptidyl-histidine modification (GO:0018202)2.68340678
68cellular response to zinc ion (GO:0071294)2.67716363
69astrocyte development (GO:0014002)2.67443599
70ventricular cardiac muscle cell development (GO:0055015)2.66497709
71DNA double-strand break processing (GO:0000729)2.66345521
72regulation of rhodopsin mediated signaling pathway (GO:0022400)2.64851847
73histone exchange (GO:0043486)2.64291057
74leukocyte migration involved in inflammatory response (GO:0002523)2.64204099
75cytochrome complex assembly (GO:0017004)2.63202230
76receptor guanylyl cyclase signaling pathway (GO:0007168)2.62709076
77metaphase plate congression (GO:0051310)2.61078227
78hematopoietic stem cell proliferation (GO:0071425)2.60450684
79rhodopsin mediated signaling pathway (GO:0016056)2.59419038
80water-soluble vitamin biosynthetic process (GO:0042364)2.58715756
81protein complex biogenesis (GO:0070271)2.57876702
82centrosome organization (GO:0051297)2.57362485
83ncRNA catabolic process (GO:0034661)2.57099614
84sister chromatid segregation (GO:0000819)2.55832229
85aldehyde catabolic process (GO:0046185)2.55672904
86atrial cardiac muscle cell action potential (GO:0086014)2.54572240
87negative regulation of DNA-dependent DNA replication (GO:2000104)2.52565384
88recombinational repair (GO:0000725)2.51371881
89mitochondrial respiratory chain complex assembly (GO:0033108)2.50849805
90negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.48963914
91double-strand break repair via homologous recombination (GO:0000724)2.48242134
92detection of mechanical stimulus involved in sensory perception (GO:0050974)2.47277933
93central nervous system projection neuron axonogenesis (GO:0021952)2.46812833
94adenosine metabolic process (GO:0046085)2.44356341
95regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.43504294
96DNA demethylation (GO:0080111)2.41975476
97mitochondrial respiratory chain complex I assembly (GO:0032981)2.41455506
98NADH dehydrogenase complex assembly (GO:0010257)2.41455506
99mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.41455506
100chondrocyte proliferation (GO:0035988)2.41000290

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.32983618
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.23434865
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.98399370
4ZNF274_21170338_ChIP-Seq_K562_Hela3.88914866
5EZH2_22144423_ChIP-Seq_EOC_Human3.40665573
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.26388040
7GBX2_23144817_ChIP-Seq_PC3_Human3.19746055
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.04748509
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.83861429
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.68901941
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.44106964
12RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.42072998
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.41429692
14EWS_26573619_Chip-Seq_HEK293_Human2.28887817
15FUS_26573619_Chip-Seq_HEK293_Human2.18415924
16TP63_19390658_ChIP-ChIP_HaCaT_Human2.17812936
17VDR_22108803_ChIP-Seq_LS180_Human2.15940077
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.11536608
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.10238922
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.09172795
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.08940988
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.07577702
23E2F4_17652178_ChIP-ChIP_JURKAT_Human1.93146854
24POU5F1_16153702_ChIP-ChIP_HESCs_Human1.83751376
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83427262
26P300_19829295_ChIP-Seq_ESCs_Human1.79877694
27EST1_17652178_ChIP-ChIP_JURKAT_Human1.79238941
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.78455081
29ELK1_19687146_ChIP-ChIP_HELA_Human1.77544651
30ER_23166858_ChIP-Seq_MCF-7_Human1.69841913
31BCAT_22108803_ChIP-Seq_LS180_Human1.67232098
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.65912198
33IGF1R_20145208_ChIP-Seq_DFB_Human1.63541363
34GABP_17652178_ChIP-ChIP_JURKAT_Human1.59958877
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.58717633
36AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.54730556
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53991625
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53536784
39MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.45838766
40CBP_20019798_ChIP-Seq_JUKART_Human1.44472756
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44472756
42MYC_18940864_ChIP-ChIP_HL60_Human1.43646355
43TAF15_26573619_Chip-Seq_HEK293_Human1.43354135
44NR3C1_21868756_ChIP-Seq_MCF10A_Human1.43036048
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42873654
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.38453090
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.33926365
48OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32513856
49PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31915726
50MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30843758
51CREB1_15753290_ChIP-ChIP_HEK293T_Human1.29984069
52SMAD4_21799915_ChIP-Seq_A2780_Human1.27611379
53AR_25329375_ChIP-Seq_VCAP_Human1.27502451
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27089108
55SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25678015
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22455492
57BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.21549237
58PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20889824
59TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.19540757
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.19166718
61TCF4_22108803_ChIP-Seq_LS180_Human1.18290636
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.17341943
63GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15926621
64PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15427274
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15398639
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15337800
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15337800
68STAT3_23295773_ChIP-Seq_U87_Human1.13998572
69CDX2_22108803_ChIP-Seq_LS180_Human1.12518029
70KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.12148690
71IRF1_19129219_ChIP-ChIP_H3396_Human1.11114498
72CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.10088072
73SOX2_19829295_ChIP-Seq_ESCs_Human1.09099311
74NANOG_19829295_ChIP-Seq_ESCs_Human1.09099311
75SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.08057958
76SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07819085
77TCF4_23295773_ChIP-Seq_U87_Human1.05998170
78RUNX2_22187159_ChIP-Seq_PCA_Human1.04523391
79AR_21909140_ChIP-Seq_LNCAP_Human1.02027120
80KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00650992
81NFE2_27457419_Chip-Seq_LIVER_Mouse0.98171826
82SMAD_19615063_ChIP-ChIP_OVARY_Human0.97010802
83TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96437021
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96140323
85VDR_23849224_ChIP-Seq_CD4+_Human0.94316530
86HOXB7_26014856_ChIP-Seq_BT474_Human0.93117839
87AR_21572438_ChIP-Seq_LNCaP_Human0.92339450
88NOTCH1_21737748_ChIP-Seq_TLL_Human0.92016834
89BRD4_25478319_ChIP-Seq_HGPS_Human0.91907176
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91727199
91CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.91222640
92SOX2_16153702_ChIP-ChIP_HESCs_Human0.90318281
93PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90028623
94NANOG_18555785_Chip-Seq_ESCs_Mouse0.89953041
95SMAD4_21741376_ChIP-Seq_EPCs_Human0.89102070
96CRX_20693478_ChIP-Seq_RETINA_Mouse0.88884790
97TBX3_20139965_ChIP-Seq_ESCs_Mouse0.88642061
98CBX2_27304074_Chip-Seq_ESCs_Mouse0.88377376
99SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.88367901
100HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.88236413

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology6.66391371
2MP0003787_abnormal_imprinting3.65259792
3MP0004885_abnormal_endolymph3.64527950
4MP0000049_abnormal_middle_ear2.81395421
5MP0008877_abnormal_DNA_methylation2.73216181
6MP0001485_abnormal_pinna_reflex2.66509123
7MP0008438_abnormal_cutaneous_collagen2.57096161
8MP0009697_abnormal_copulation2.39144812
9MP0006292_abnormal_olfactory_placode2.35901684
10MP0003195_calcinosis2.25609244
11MP0002653_abnormal_ependyma_morphology2.21187541
12MP0001764_abnormal_homeostasis2.20635231
13MP0006072_abnormal_retinal_apoptosis2.18530463
14MP0003121_genomic_imprinting2.06155742
15MP0006054_spinal_hemorrhage2.03498310
16MP0009780_abnormal_chondrocyte_physiolo2.02346767
17MP0010094_abnormal_chromosome_stability1.90318416
18MP0005253_abnormal_eye_physiology1.85618845
19MP0001984_abnormal_olfaction1.85069083
20MP0005646_abnormal_pituitary_gland1.84275093
21MP0002751_abnormal_autonomic_nervous1.71654494
22MP0005503_abnormal_tendon_morphology1.68861778
23MP0002233_abnormal_nose_morphology1.63136294
24MP0004742_abnormal_vestibular_system1.59991754
25MP0002009_preneoplasia1.57437018
26MP0005275_abnormal_skin_tensile1.48427967
27MP0000516_abnormal_urinary_system1.48120636
28MP0005367_renal/urinary_system_phenotyp1.48120636
29MP0005499_abnormal_olfactory_system1.47017250
30MP0005394_taste/olfaction_phenotype1.47017250
31MP0005551_abnormal_eye_electrophysiolog1.46773625
32MP0000631_abnormal_neuroendocrine_gland1.46125263
33MP0003937_abnormal_limbs/digits/tail_de1.44480633
34MP0003693_abnormal_embryo_hatching1.39666227
35MP0003755_abnormal_palate_morphology1.39602900
36MP0003938_abnormal_ear_development1.38257066
37MP0008058_abnormal_DNA_repair1.37517054
38MP0002090_abnormal_vision1.34394510
39MP0005423_abnormal_somatic_nervous1.33258885
40MP0001486_abnormal_startle_reflex1.27518472
41MP0002938_white_spotting1.26814159
42MP0000026_abnormal_inner_ear1.26657445
43MP0001661_extended_life_span1.26077633
44MP0002234_abnormal_pharynx_morphology1.22071052
45MP0008872_abnormal_physiological_respon1.21392649
46MP0000427_abnormal_hair_cycle1.20392399
47MP0003646_muscle_fatigue1.20289025
48MP0008789_abnormal_olfactory_epithelium1.18148463
49MP0002736_abnormal_nociception_after1.17891505
50MP0009745_abnormal_behavioral_response1.16141162
51MP0000432_abnormal_head_morphology1.15604896
52MP0005391_vision/eye_phenotype1.12873032
53MP0003880_abnormal_central_pattern1.12382373
54MP0000778_abnormal_nervous_system1.09693064
55MP0003122_maternal_imprinting1.09428487
56MP0002116_abnormal_craniofacial_bone1.05182622
57MP0004147_increased_porphyrin_level1.05090982
58MP0003718_maternal_effect1.03662295
59MP0001963_abnormal_hearing_physiology0.96822606
60MP0002272_abnormal_nervous_system0.96749128
61MP0002282_abnormal_trachea_morphology0.95987491
62MP0003385_abnormal_body_wall0.95831396
63MP0001270_distended_abdomen0.95195516
64MP0001968_abnormal_touch/_nociception0.95138559
65MP0003186_abnormal_redox_activity0.89767633
66MP0001119_abnormal_female_reproductive0.89483605
67MP0002108_abnormal_muscle_morphology0.88221079
68MP0008932_abnormal_embryonic_tissue0.87875286
69MP0001286_abnormal_eye_development0.87846536
70MP0003656_abnormal_erythrocyte_physiolo0.86896335
71MP0005389_reproductive_system_phenotype0.86327253
72MP0002177_abnormal_outer_ear0.84470303
73MP0004215_abnormal_myocardial_fiber0.84423950
74MP0003119_abnormal_digestive_system0.84234897
75MP0005171_absent_coat_pigmentation0.82673817
76MP0001929_abnormal_gametogenesis0.82381826
77MP0001919_abnormal_reproductive_system0.82208278
78MP0001529_abnormal_vocalization0.81901665
79MP0000647_abnormal_sebaceous_gland0.81620896
80MP0002928_abnormal_bile_duct0.79655053
81MP0009250_abnormal_appendicular_skeleto0.79032068
82MP0008007_abnormal_cellular_replicative0.77305103
83MP0005395_other_phenotype0.76052277
84MP0000163_abnormal_cartilage_morphology0.75589371
85MP0002210_abnormal_sex_determination0.75239769
86MP0000538_abnormal_urinary_bladder0.75022059
87MP0001299_abnormal_eye_distance/0.73258620
88MP0002098_abnormal_vibrissa_morphology0.73250080
89MP0003861_abnormal_nervous_system0.72985266
90MP0000569_abnormal_digit_pigmentation0.72781360
91MP0002752_abnormal_somatic_nervous0.72543086
92MP0004133_heterotaxia0.72123148
93MP0010030_abnormal_orbit_morphology0.72085824
94MP0004134_abnormal_chest_morphology0.71884482
95MP0002109_abnormal_limb_morphology0.71473368
96MP0000653_abnormal_sex_gland0.69621737
97MP0003890_abnormal_embryonic-extraembry0.69542888
98MP0002734_abnormal_mechanical_nocicepti0.68890711
99MP0002184_abnormal_innervation0.68750925
100MP0002111_abnormal_tail_morphology0.68089785

Predicted human phenotypes

RankGene SetZ-score
1Hypoplastic pelvis (HP:0008839)5.33383522
2Optic nerve hypoplasia (HP:0000609)4.29907493
3Aplasia/Hypoplasia of the optic nerve (HP:0008058)3.76124154
4Pancreatic fibrosis (HP:0100732)3.63227980
5Ectopic kidney (HP:0000086)3.58207224
6Abnormality of the labia minora (HP:0012880)3.54778311
7Nephronophthisis (HP:0000090)3.39667177
8Hypoplastic female external genitalia (HP:0012815)3.34925707
9Intestinal atresia (HP:0011100)3.31763765
10Short tibia (HP:0005736)3.31733399
11Long clavicles (HP:0000890)3.26491796
12Abnormality of the renal medulla (HP:0100957)3.23997719
13Aplasia/Hypoplasia of the tibia (HP:0005772)3.18810881
14Progressive inability to walk (HP:0002505)3.16562631
15Abnormality of midbrain morphology (HP:0002418)3.14941644
16Molar tooth sign on MRI (HP:0002419)3.14941644
17Chronic hepatic failure (HP:0100626)2.99269179
18Abdominal situs inversus (HP:0003363)2.91189778
19Abnormality of abdominal situs (HP:0011620)2.91189778
20Pancreatic cysts (HP:0001737)2.87431808
21Abnormality of the renal cortex (HP:0011035)2.86323832
22True hermaphroditism (HP:0010459)2.85137481
23Aplasia/Hypoplasia of the sacrum (HP:0008517)2.82647056
24Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.81239600
25Short 1st metacarpal (HP:0010034)2.81239600
26Delayed gross motor development (HP:0002194)2.79851908
27Hepatoblastoma (HP:0002884)2.76947971
28Oligodactyly (hands) (HP:0001180)2.74775380
29Thyroiditis (HP:0100646)2.74534573
30Hypoplastic labia majora (HP:0000059)2.68665907
31Abnormality of the labia majora (HP:0012881)2.67246970
32Aplasia/Hypoplasia of the tongue (HP:0010295)2.59529661
33Growth hormone deficiency (HP:0000824)2.59191032
34Volvulus (HP:0002580)2.59013956
35Facial hemangioma (HP:0000329)2.55455168
36Mutism (HP:0002300)2.53149231
37Septo-optic dysplasia (HP:0100842)2.50178389
38Tubular atrophy (HP:0000092)2.46265579
39Fibular hypoplasia (HP:0003038)2.45735685
40Abnormality of the 1st metacarpal (HP:0010009)2.44226041
41Labial hypoplasia (HP:0000066)2.42883087
42Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.36412493
43Epidermoid cyst (HP:0200040)2.33076303
44Small hand (HP:0200055)2.32766003
45Disproportionate short-trunk short stature (HP:0003521)2.29879315
46Abnormal lung lobation (HP:0002101)2.26993594
47Carpal bone hypoplasia (HP:0001498)2.21261323
48Microglossia (HP:0000171)2.19696334
49Generalized tonic-clonic seizures (HP:0002069)2.18188284
50Gastrointestinal atresia (HP:0002589)2.16532956
51Irregular epiphyses (HP:0010582)2.14753545
52Postaxial hand polydactyly (HP:0001162)2.13306281
53Oligodactyly (HP:0012165)2.09971703
54Cerebellar dysplasia (HP:0007033)2.09219590
55Ulnar claw (HP:0001178)2.05698518
56Shallow orbits (HP:0000586)2.04774861
57Aplasia/Hypoplasia of the nipples (HP:0006709)2.04460470
58Sloping forehead (HP:0000340)2.03844776
59Hypoplasia of the capital femoral epiphysis (HP:0003090)2.03389255
60Hip dysplasia (HP:0001385)2.03250814
61Genital tract atresia (HP:0001827)2.01973626
62Postaxial foot polydactyly (HP:0001830)2.00652536
63Abnormality of the metopic suture (HP:0005556)1.99586263
64Increased corneal curvature (HP:0100692)1.98523147
65Keratoconus (HP:0000563)1.98523147
66Central scotoma (HP:0000603)1.97280827
67Stenosis of the external auditory canal (HP:0000402)1.93997604
68Inability to walk (HP:0002540)1.93587688
69Sclerocornea (HP:0000647)1.91680260
70Decreased lacrimation (HP:0000633)1.90075396
71Abnormality of the labia (HP:0000058)1.89805493
72Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.89796045
73Aplasia/Hypoplasia of the sternum (HP:0006714)1.87563711
74Focal seizures (HP:0007359)1.86833192
75Abnormal drinking behavior (HP:0030082)1.86708321
76Polydipsia (HP:0001959)1.86708321
77Aqueductal stenosis (HP:0002410)1.86452406
78Cystic liver disease (HP:0006706)1.85765377
79Dandy-Walker malformation (HP:0001305)1.82165666
80Pachygyria (HP:0001302)1.80848980
81Increased density of long bones (HP:0006392)1.78245803
82Ependymoma (HP:0002888)1.77564643
83Preaxial hand polydactyly (HP:0001177)1.76615112
84Highly arched eyebrow (HP:0002553)1.75804308
85Abnormality of the fetal cardiovascular system (HP:0010948)1.75232802
86Abnormal umbilical cord blood vessels (HP:0011403)1.75232802
87Single umbilical artery (HP:0001195)1.75232802
88Chorioretinal coloboma (HP:0000567)1.73014444
89Hypoplastic iliac wings (HP:0002866)1.72297089
90Severe Myopia (HP:0011003)1.72281038
91Selective tooth agenesis (HP:0001592)1.71541211
92Polyuria (HP:0000103)1.70529336
93Anophthalmia (HP:0000528)1.69507817
94Asplenia (HP:0001746)1.69247060
95Type II lissencephaly (HP:0007260)1.67897894
96Absent thumb (HP:0009777)1.67320648
97Aplasia/Hypoplasia of the fibula (HP:0006492)1.67291394
98Abnormal biliary tract physiology (HP:0012439)1.66927095
99Bile duct proliferation (HP:0001408)1.66927095
100Medial flaring of the eyebrow (HP:0010747)1.66914447

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.20058485
2TNIK3.62721982
3FRK3.15643235
4WNK33.07323895
5BRSK23.05766745
6KSR12.37982167
7BCR2.37770184
8STK392.35787266
9TRIM282.33795356
10INSRR2.31262904
11RPS6KA42.19461368
12ZAK2.16695860
13DYRK32.13225473
14NUAK11.84457591
15DYRK21.79443176
16ERBB31.77408255
17PLK31.70244050
18EPHB21.67844734
19PKN11.66483077
20MINK11.64584263
21SRPK11.53695741
22MAPK131.52717068
23MAP3K21.50448367
24NTRK31.49209180
25TLK11.44998736
26NLK1.44074468
27NEK11.41266909
28BMPR1B1.39047547
29CASK1.38543388
30PAK31.36254999
31ADRBK21.29709427
32BRSK11.29226466
33MAP4K21.27544070
34OXSR11.21325194
35WNK41.18802892
36STK161.17116459
37GRK11.14317255
38CDC71.11062061
39PLK41.10225142
40BUB11.07669345
41RAF11.06314127
42CAMK41.03328722
43CDK31.01417701
44CHEK20.98578179
45PRKCE0.94909934
46MAP3K80.93602798
47ERBB20.92512807
48MAP3K40.89651188
49CCNB10.88149642
50KSR20.86543219
51TTK0.85245779
52SIK30.82753782
53PASK0.78081657
54MKNK20.77164022
55FGFR20.74559709
56TGFBR10.74554951
57MAP3K70.73964220
58TIE10.72006977
59ALK0.71881973
60EIF2AK20.70521312
61PLK20.69171285
62PTK2B0.68285117
63CSNK1G10.66984982
64PLK10.66332492
65EIF2AK30.63169276
66DDR20.63137162
67PINK10.63003335
68AURKB0.62976963
69SGK20.61682199
70MKNK10.61442043
71CDK60.58025839
72MARK30.55141562
73ROCK10.55018768
74GRK60.54018315
75CSNK1G20.53972675
76NME10.53784809
77CAMKK20.50212457
78ACVR1B0.48397196
79ATM0.43984349
80STK30.42996517
81FGFR10.42877476
82CAMK1D0.41592385
83ATR0.41309989
84CAMK2D0.40885662
85CAMK1G0.40251767
86CAMK2B0.39801542
87PIK3CA0.38037321
88RPS6KA50.37176529
89NEK60.35783722
90PRKCG0.35658458
91CSNK1A10.35540986
92HIPK20.35484436
93GSK3A0.35390404
94FER0.33947850
95MAP3K100.33936994
96PRKCI0.33762557
97CSNK1G30.33240649
98ADRBK10.31751529
99LIMK10.27974344
100CSNK2A10.27444021

Predicted pathways (KEGG)

RankGene SetZ-score
1Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.31254024
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.01821163
3Steroid biosynthesis_Homo sapiens_hsa001002.91644237
4Phototransduction_Homo sapiens_hsa047442.84467186
5Fatty acid elongation_Homo sapiens_hsa000622.56234242
6Fanconi anemia pathway_Homo sapiens_hsa034602.49925080
7Homologous recombination_Homo sapiens_hsa034402.22581633
8Protein export_Homo sapiens_hsa030602.17676512
9Non-homologous end-joining_Homo sapiens_hsa034502.15668643
10Nicotine addiction_Homo sapiens_hsa050332.10810066
11Butanoate metabolism_Homo sapiens_hsa006502.05622842
12Basal transcription factors_Homo sapiens_hsa030221.98202428
13Basal cell carcinoma_Homo sapiens_hsa052171.88486361
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.81265521
15Hedgehog signaling pathway_Homo sapiens_hsa043401.78744816
16Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.54768471
17RNA polymerase_Homo sapiens_hsa030201.51389203
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.47052788
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.47043765
20Cyanoamino acid metabolism_Homo sapiens_hsa004601.42240906
21Selenocompound metabolism_Homo sapiens_hsa004501.41854820
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.41017577
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.37792711
24Oxidative phosphorylation_Homo sapiens_hsa001901.36749528
25Nucleotide excision repair_Homo sapiens_hsa034201.36547973
26p53 signaling pathway_Homo sapiens_hsa041151.34634578
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.32199357
28Propanoate metabolism_Homo sapiens_hsa006401.30773327
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.26161657
30Oocyte meiosis_Homo sapiens_hsa041141.23605022
31RNA degradation_Homo sapiens_hsa030181.23342086
32Proteasome_Homo sapiens_hsa030501.23301020
33Chemical carcinogenesis_Homo sapiens_hsa052041.19275278
34Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.18859924
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.15236856
36Mismatch repair_Homo sapiens_hsa034301.15224393
37Parkinsons disease_Homo sapiens_hsa050121.14779888
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.11044745
39Cell cycle_Homo sapiens_hsa041101.10281224
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09284296
41Linoleic acid metabolism_Homo sapiens_hsa005911.03742980
42Huntingtons disease_Homo sapiens_hsa050161.01891459
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.01083084
44Fatty acid metabolism_Homo sapiens_hsa012121.00285516
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.99994710
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.97713943
47Melanoma_Homo sapiens_hsa052180.97214382
48Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.95422713
49ECM-receptor interaction_Homo sapiens_hsa045120.91602920
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89168031
51Olfactory transduction_Homo sapiens_hsa047400.87977231
52Pyrimidine metabolism_Homo sapiens_hsa002400.87605786
53Tryptophan metabolism_Homo sapiens_hsa003800.87258997
54Hippo signaling pathway_Homo sapiens_hsa043900.86193504
55Steroid hormone biosynthesis_Homo sapiens_hsa001400.85949484
56Cocaine addiction_Homo sapiens_hsa050300.85706691
57GABAergic synapse_Homo sapiens_hsa047270.83886582
58Purine metabolism_Homo sapiens_hsa002300.83055971
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81226932
60Circadian rhythm_Homo sapiens_hsa047100.80403394
61Fatty acid degradation_Homo sapiens_hsa000710.78757408
62Drug metabolism - other enzymes_Homo sapiens_hsa009830.78710094
63Circadian entrainment_Homo sapiens_hsa047130.77006042
64Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.74381750
65Base excision repair_Homo sapiens_hsa034100.74121355
66Lysine degradation_Homo sapiens_hsa003100.72096400
67Morphine addiction_Homo sapiens_hsa050320.70487027
68Peroxisome_Homo sapiens_hsa041460.70249384
69TGF-beta signaling pathway_Homo sapiens_hsa043500.69963055
70Glutathione metabolism_Homo sapiens_hsa004800.69262737
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67839713
72RNA transport_Homo sapiens_hsa030130.67421722
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.66597683
74Retinol metabolism_Homo sapiens_hsa008300.65010067
75One carbon pool by folate_Homo sapiens_hsa006700.64560152
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.62863276
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61528378
78Taste transduction_Homo sapiens_hsa047420.60313119
79Serotonergic synapse_Homo sapiens_hsa047260.58085645
80Nitrogen metabolism_Homo sapiens_hsa009100.56705775
81Cardiac muscle contraction_Homo sapiens_hsa042600.54300697
82Wnt signaling pathway_Homo sapiens_hsa043100.53297836
83Dorso-ventral axis formation_Homo sapiens_hsa043200.52989520
84PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52630092
85Prostate cancer_Homo sapiens_hsa052150.52276743
86Ether lipid metabolism_Homo sapiens_hsa005650.52250109
87Fat digestion and absorption_Homo sapiens_hsa049750.50394116
88Melanogenesis_Homo sapiens_hsa049160.48982694
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48963543
90Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.48822058
91Metabolic pathways_Homo sapiens_hsa011000.46512438
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46359636
93Mineral absorption_Homo sapiens_hsa049780.45379220
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44436096
95Ovarian steroidogenesis_Homo sapiens_hsa049130.44138898
96Alzheimers disease_Homo sapiens_hsa050100.43819725
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42633185
98Glutamatergic synapse_Homo sapiens_hsa047240.41410137
99Dopaminergic synapse_Homo sapiens_hsa047280.40401435
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35108441

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »