ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	6.00391585
2	behavioral response to nicotine (GO:0035095)	5.47175249
3	protein-cofactor linkage (GO:0018065)	5.35448283
4	head development (GO:0060322)	5.10687745
5	DNA integration (GO:0015074)	4.95945148
6	monoubiquitinated protein deubiquitination (GO:0035520)	4.75627053
7	positive regulation of male gonad development (GO:2000020)	4.72416709
8	response to nitrosative stress (GO:0051409)	4.58990998
9	microtubule depolymerization (GO:0007019)	4.54538939
10	limb bud formation (GO:0060174)	4.28880626
11	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.26075740
12	fibroblast migration (GO:0010761)	4.21705711
13	nucleobase biosynthetic process (GO:0046112)	4.17007613
14	olfactory bulb development (GO:0021772)	4.16061278
15	kinetochore organization (GO:0051383)	4.02462391
16	negative regulation of axon guidance (GO:1902668)	4.01934334
17	purine nucleobase biosynthetic process (GO:0009113)	3.96742779
18	negative regulation of axon extension involved in axon guidance (GO:0048843)	3.96099316
19	regulation of male gonad development (GO:2000018)	3.89513388
20	pyrimidine nucleobase catabolic process (GO:0006208)	3.89293963
21	cornea development in camera-type eye (GO:0061303)	3.74585988
22	platelet dense granule organization (GO:0060155)	3.66401232
23	tongue development (GO:0043586)	3.60967513
24	long-chain fatty acid biosynthetic process (GO:0042759)	3.51920679
25	synaptic transmission, cholinergic (GO:0007271)	3.49765662
26	astrocyte development (GO:0014002)	3.45506362
27	retinal ganglion cell axon guidance (GO:0031290)	3.42010567
28	mesenchymal-epithelial cell signaling (GO:0060638)	3.39320029
29	glycosphingolipid biosynthetic process (GO:0006688)	3.36206183
30	protein localization to cilium (GO:0061512)	3.34844975
31	cellular response to follicle-stimulating hormone stimulus (GO:0071372)	3.34659815
32	neuronal action potential propagation (GO:0019227)	3.32453083
33	pituitary gland development (GO:0021983)	3.31643847
34	DNA topological change (GO:0006265)	3.30737878
35	lateral sprouting from an epithelium (GO:0060601)	3.22155650
36	C4-dicarboxylate transport (GO:0015740)	3.21123554
37	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	3.17352475
38	negative chemotaxis (GO:0050919)	3.16583128
39	microtubule polymerization or depolymerization (GO:0031109)	3.15510919
40	nucleobase catabolic process (GO:0046113)	3.15440980
41	regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)	3.12404986
42	cellular response to gamma radiation (GO:0071480)	3.10467447
43	N-terminal protein amino acid modification (GO:0031365)	3.04823865
44	arginine catabolic process (GO:0006527)	3.04567468
45	kinetochore assembly (GO:0051382)	3.04563651
46	nonmotile primary cilium assembly (GO:0035058)	3.00250722
47	left/right axis specification (GO:0070986)	2.99234737
48	fatty acid elongation (GO:0030497)	2.99226667
49	replication fork processing (GO:0031297)	2.97308391
50	prostate gland growth (GO:0060736)	2.97162033
51	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	2.96266457
52	neural tube formation (GO:0001841)	2.94587841
53	cullin deneddylation (GO:0010388)	2.88779774
54	protein K6-linked ubiquitination (GO:0085020)	2.87665637
55	anatomical structure regression (GO:0060033)	2.86279793
56	axonal fasciculation (GO:0007413)	2.83602482
57	DNA double-strand break processing (GO:0000729)	2.80721397
58	photoreceptor cell maintenance (GO:0045494)	2.79540825
59	hindbrain development (GO:0030902)	2.78997300
60	arginine metabolic process (GO:0006525)	2.77357008
61	regulation of vascular endothelial growth factor signaling pathway (GO:1900746)	2.75717095
62	intraciliary transport (GO:0042073)	2.73323808
63	chromatin remodeling at centromere (GO:0031055)	2.67416703
64	transmission of nerve impulse (GO:0019226)	2.66468103
65	regulation of sister chromatid cohesion (GO:0007063)	2.65421345
66	respiratory chain complex IV assembly (GO:0008535)	2.65328672
67	regulation of neuron migration (GO:2001222)	2.65136628
68	glycolipid biosynthetic process (GO:0009247)	2.64030878
69	secretory granule organization (GO:0033363)	2.63302136
70	negative regulation of epidermal cell differentiation (GO:0045605)	2.61670465
71	mRNA modification (GO:0016556)	2.61573138
72	preassembly of GPI anchor in ER membrane (GO:0016254)	2.61439526
73	double-strand break repair via homologous recombination (GO:0000724)	2.61345720
74	recombinational repair (GO:0000725)	2.60678818
75	GPI anchor metabolic process (GO:0006505)	2.60355432
76	dorsal/ventral axis specification (GO:0009950)	2.58333378
77	negative regulation of Ras GTPase activity (GO:0034261)	2.57022073
78	protein deneddylation (GO:0000338)	2.56701535
79	short-term memory (GO:0007614)	2.56235921
80	inner ear receptor cell development (GO:0060119)	2.54737814
81	GMP metabolic process (GO:0046037)	2.54613053
82	response to follicle-stimulating hormone (GO:0032354)	2.54287297
83	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.53574162
84	positive regulation of mitotic sister chromatid separation (GO:1901970)	2.52644799
85	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	2.52644799
86	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	2.52644799
87	negative regulation of transcription by competitive promoter binding (GO:0010944)	2.51807978
88	thalamus development (GO:0021794)	2.51399607
89	resolution of meiotic recombination intermediates (GO:0000712)	2.51342525
90	positive regulation of mitochondrial fission (GO:0090141)	2.50666517
91	centriole replication (GO:0007099)	2.50460696
92	neuromuscular synaptic transmission (GO:0007274)	2.49809938
93	regulation of glucokinase activity (GO:0033131)	2.48985364
94	regulation of hexokinase activity (GO:1903299)	2.48985364
95	cilium organization (GO:0044782)	2.48400460
96	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.47030004
97	meiotic chromosome segregation (GO:0045132)	2.46651361
98	branched-chain amino acid catabolic process (GO:0009083)	2.45721557
99	outer ear morphogenesis (GO:0042473)	2.45665748
100	startle response (GO:0001964)	2.44680014

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.06103906
2	SALL1_21062744_ChIP-ChIP_HESCs_Human	4.15544790
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	4.09040894
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.85223998
5	EZH2_22144423_ChIP-Seq_EOC_Human	3.42300645
6	GBX2_23144817_ChIP-Seq_PC3_Human	3.19663854
7	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	3.05676611
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.57733829
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.56629895
10	EWS_26573619_Chip-Seq_HEK293_Human	2.48679617
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.44432377
12	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.43879566
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.35296129
14	IGF1R_20145208_ChIP-Seq_DFB_Human	2.33672051
15	FUS_26573619_Chip-Seq_HEK293_Human	2.33301983
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.21359457
17	VDR_22108803_ChIP-Seq_LS180_Human	2.19774115
18	P300_19829295_ChIP-Seq_ESCs_Human	2.09720351
19	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.99041961
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.97463938
21	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.96488671
22	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.95194811
23	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.89810257
24	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.86709720
25	TAF15_26573619_Chip-Seq_HEK293_Human	1.75983091
26	ER_23166858_ChIP-Seq_MCF-7_Human	1.74135545
27	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.73474870
28	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.71181046
29	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.69577114
30	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.65715048
31	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.65458622
32	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.63826875
33	BCAT_22108803_ChIP-Seq_LS180_Human	1.62476749
34	IRF1_19129219_ChIP-ChIP_H3396_Human	1.56173332
35	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.55991591
36	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.53684763
37	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.52599091
38	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.51194733
39	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.48330691
40	AR_25329375_ChIP-Seq_VCAP_Human	1.47977362
41	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.47543549
42	SMAD4_21799915_ChIP-Seq_A2780_Human	1.47121335
43	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.45538815
44	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.45389058
45	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.43662153
46	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.40104222
47	CBP_20019798_ChIP-Seq_JUKART_Human	1.39319478
48	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.39319478
49	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.37273009
50	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.37273009
51	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.34969004
52	MYC_18940864_ChIP-ChIP_HL60_Human	1.34422656
53	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.34250043
54	STAT3_23295773_ChIP-Seq_U87_Human	1.33887538
55	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.33081652
56	ELK1_19687146_ChIP-ChIP_HELA_Human	1.32956250
57	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.27936773
58	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.27100483
59	TCF4_23295773_ChIP-Seq_U87_Human	1.26109793
60	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.25579903
61	TCF4_22108803_ChIP-Seq_LS180_Human	1.25095214
62	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.24721768
63	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.23884061
64	RUNX2_22187159_ChIP-Seq_PCA_Human	1.23130992
65	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.22282297
66	NANOG_19829295_ChIP-Seq_ESCs_Human	1.17046393
67	SOX2_19829295_ChIP-Seq_ESCs_Human	1.17046393
68	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.16541229
69	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.16175720
70	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.14803685
71	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.14741297
72	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.12993536
73	CDX2_22108803_ChIP-Seq_LS180_Human	1.12495421
74	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.10957672
75	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.10090263
76	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.10059757
77	RXR_22108803_ChIP-Seq_LS180_Human	1.05076233
78	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.04277638
79	TP53_18474530_ChIP-ChIP_U2OS_Human	1.03673197
80	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.02672001
81	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.01111313
82	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.00771221
83	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.00521746
84	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.99279124
85	TBX3_20139965_ChIP-Seq_ESCs_Mouse	0.98472816
86	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.97214030
87	WT1_19549856_ChIP-ChIP_CCG9911_Human	0.97142020
88	TBX3_20139965_ChIP-Seq_MESCs_Mouse	0.97028470
89	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	0.96933785
90	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96112508
91	KDM2B_26808549_Chip-Seq_REH_Human	0.93787892
92	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	0.92348683
93	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.91693779
94	SOX9_26525672_Chip-Seq_HEART_Mouse	0.91447296
95	JUN_21703547_ChIP-Seq_K562_Human	0.90800677
96	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	0.90755219
97	AR_21572438_ChIP-Seq_LNCaP_Human	0.90712550
98	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.89702884
99	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.89680730
100	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.89482675

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	4.21583330
2	MP0002653_abnormal_ependyma_morphology	4.07891508
3	MP0006292_abnormal_olfactory_placode	3.00415028
4	MP0003787_abnormal_imprinting	2.83959769
5	MP0006072_abnormal_retinal_apoptosis	2.77500840
6	MP0000049_abnormal_middle_ear	2.65555087
7	MP0008877_abnormal_DNA_methylation	2.52166647
8	MP0004885_abnormal_endolymph	2.43430403
9	MP0002009_preneoplasia	2.30878608
10	MP0002751_abnormal_autonomic_nervous	2.17040493
11	MP0009780_abnormal_chondrocyte_physiolo	2.16852254
12	MP0009697_abnormal_copulation	2.15554653
13	MP0003122_maternal_imprinting	2.08494238
14	MP0000383_abnormal_hair_follicle	1.99327026
15	MP0001764_abnormal_homeostasis	1.93240443
16	MP0002233_abnormal_nose_morphology	1.90049214
17	MP0005253_abnormal_eye_physiology	1.87197040
18	MP0003880_abnormal_central_pattern	1.85943707
19	MP0001529_abnormal_vocalization	1.84471255
20	MP0004133_heterotaxia	1.84055533
21	MP0005367_renal/urinary_system_phenotyp	1.77123802
22	MP0000516_abnormal_urinary_system	1.77123802
23	MP0003121_genomic_imprinting	1.76762640
24	MP0003937_abnormal_limbs/digits/tail_de	1.68336845
25	MP0000778_abnormal_nervous_system	1.66421699
26	MP0001485_abnormal_pinna_reflex	1.66140338
27	MP0005171_absent_coat_pigmentation	1.65727940
28	MP0003755_abnormal_palate_morphology	1.59617524
29	MP0003656_abnormal_erythrocyte_physiolo	1.58239973
30	MP0006054_spinal_hemorrhage	1.54671951
31	MP0005394_taste/olfaction_phenotype	1.54408399
32	MP0005499_abnormal_olfactory_system	1.54408399
33	MP0010030_abnormal_orbit_morphology	1.44077602
34	MP0004742_abnormal_vestibular_system	1.42064525
35	MP0000427_abnormal_hair_cycle	1.37045837
36	MP0000026_abnormal_inner_ear	1.36976987
37	MP0003693_abnormal_embryo_hatching	1.36780294
38	MP0001984_abnormal_olfaction	1.31910911
39	MP0003195_calcinosis	1.31353201
40	MP0002736_abnormal_nociception_after	1.31315472
41	MP0001299_abnormal_eye_distance/	1.31221925
42	MP0001293_anophthalmia	1.30841460
43	MP0010678_abnormal_skin_adnexa	1.30474593
44	MP0002234_abnormal_pharynx_morphology	1.26860165
45	MP0000631_abnormal_neuroendocrine_gland	1.26607913
46	MP0008789_abnormal_olfactory_epithelium	1.26317531
47	MP0002116_abnormal_craniofacial_bone	1.25457109
48	MP0002938_white_spotting	1.22834426
49	MP0005551_abnormal_eye_electrophysiolog	1.21041441
50	MP0003890_abnormal_embryonic-extraembry	1.20224626
51	MP0001968_abnormal_touch/_nociception	1.14437028
52	MP0000432_abnormal_head_morphology	1.14299622
53	MP0003186_abnormal_redox_activity	1.12388503
54	MP0001286_abnormal_eye_development	1.12185598
55	MP0001486_abnormal_startle_reflex	1.12124856
56	MP0005391_vision/eye_phenotype	1.11118896
57	MP0000538_abnormal_urinary_bladder	1.10986048
58	MP0003938_abnormal_ear_development	1.10373557
59	MP0000566_synostosis	1.08791853
60	MP0000647_abnormal_sebaceous_gland	1.07485186
61	MP0005646_abnormal_pituitary_gland	1.06934444
62	MP0010094_abnormal_chromosome_stability	1.06386461
63	MP0008058_abnormal_DNA_repair	1.04749865
64	MP0009745_abnormal_behavioral_response	1.01461802
65	MP0003385_abnormal_body_wall	1.00058757
66	MP0003861_abnormal_nervous_system	0.98944419
67	MP0001963_abnormal_hearing_physiology	0.98614662
68	MP0008057_abnormal_DNA_replication	0.95294486
69	MP0004134_abnormal_chest_morphology	0.93719839
70	MP0004147_increased_porphyrin_level	0.92761225
71	MP0001270_distended_abdomen	0.92411569
72	MP0002090_abnormal_vision	0.90954268
73	MP0008932_abnormal_embryonic_tissue	0.90784386
74	MP0002108_abnormal_muscle_morphology	0.90028815
75	MP0002272_abnormal_nervous_system	0.89373042
76	MP0003119_abnormal_digestive_system	0.89254638
77	MP0002752_abnormal_somatic_nervous	0.88421031
78	MP0003567_abnormal_fetal_cardiomyocyte	0.87248795
79	MP0005503_abnormal_tendon_morphology	0.86139009
80	MP0002177_abnormal_outer_ear	0.86088022
81	MP0000428_abnormal_craniofacial_morphol	0.85529906
82	MP0002098_abnormal_vibrissa_morphology	0.85278126
83	MP0002184_abnormal_innervation	0.79311486
84	MP0006276_abnormal_autonomic_nervous	0.77828395
85	MP0002210_abnormal_sex_determination	0.76788031
86	MP0005389_reproductive_system_phenotype	0.75498297
87	MP0001929_abnormal_gametogenesis	0.74398450
88	MP0001324_abnormal_eye_pigmentation	0.74061426
89	MP0002084_abnormal_developmental_patter	0.73980145
90	MP0001119_abnormal_female_reproductive	0.73835483
91	MP0003935_abnormal_craniofacial_develop	0.73641354
92	MP0000569_abnormal_digit_pigmentation	0.72940344
93	MP0002111_abnormal_tail_morphology	0.72791400
94	MP0008438_abnormal_cutaneous_collagen	0.71874077
95	MP0003718_maternal_effect	0.71786839
96	MP0002109_abnormal_limb_morphology	0.69951005
97	MP0002557_abnormal_social/conspecific_i	0.69495808
98	MP0002282_abnormal_trachea_morphology	0.69053561
99	MP0005423_abnormal_somatic_nervous	0.68855042
100	MP0002168_other_aberrant_phenotype	0.68418244

Predicted human phenotypes

Rank	Gene Set	Z-score
1	True hermaphroditism (HP:0010459)	4.04733222
2	Nephronophthisis (HP:0000090)	3.94433796
3	Pancreatic fibrosis (HP:0100732)	3.77595565
4	Hypoplastic pelvis (HP:0008839)	3.74716001
5	Abnormality of the renal medulla (HP:0100957)	3.53384633
6	Optic nerve hypoplasia (HP:0000609)	3.52253322
7	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.38002516
8	Abnormality of abdominal situs (HP:0011620)	3.37554157
9	Abdominal situs inversus (HP:0003363)	3.37554157
10	Long clavicles (HP:0000890)	3.36641447
11	Short tibia (HP:0005736)	3.33541225
12	Abnormality of midbrain morphology (HP:0002418)	3.31526348
13	Molar tooth sign on MRI (HP:0002419)	3.31526348
14	Ectopic kidney (HP:0000086)	3.26110580
15	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	3.21186619
16	Intestinal atresia (HP:0011100)	3.14990685
17	Disproportionate short-trunk short stature (HP:0003521)	3.09413455
18	Abnormality of the labia minora (HP:0012880)	3.08292444
19	Hypoplastic female external genitalia (HP:0012815)	2.92636801
20	Chronic hepatic failure (HP:0100626)	2.91799557
21	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.91603700
22	Oligodactyly (hands) (HP:0001180)	2.89152964
23	Genital tract atresia (HP:0001827)	2.82205850
24	Hepatoblastoma (HP:0002884)	2.80056079
25	Pancreatic cysts (HP:0001737)	2.76521181
26	Volvulus (HP:0002580)	2.76034617
27	Cerebellar dysplasia (HP:0007033)	2.71517525
28	Abnormality of the renal cortex (HP:0011035)	2.68244338
29	Labial hypoplasia (HP:0000066)	2.61429063
30	Medial flaring of the eyebrow (HP:0010747)	2.59296220
31	Fibular hypoplasia (HP:0003038)	2.56325437
32	Gastrointestinal atresia (HP:0002589)	2.46599769
33	Hypoplastic labia majora (HP:0000059)	2.44428745
34	Postaxial hand polydactyly (HP:0001162)	2.42712659
35	Septo-optic dysplasia (HP:0100842)	2.41818541
36	Abnormality of the labia majora (HP:0012881)	2.39380389
37	Vaginal atresia (HP:0000148)	2.33162288
38	Microglossia (HP:0000171)	2.31007731
39	Small hand (HP:0200055)	2.27683243
40	Thyroiditis (HP:0100646)	2.23600441
41	Postaxial foot polydactyly (HP:0001830)	2.18038970
42	Congenital primary aphakia (HP:0007707)	2.17972525
43	Oligodactyly (HP:0012165)	2.16792480
44	Chorioretinal coloboma (HP:0000567)	2.15790082
45	Delayed gross motor development (HP:0002194)	2.15043655
46	Growth hormone deficiency (HP:0000824)	2.11820980
47	Preaxial hand polydactyly (HP:0001177)	2.11738435
48	Gait imbalance (HP:0002141)	2.10188667
49	Aplasia/Hypoplasia of the nipples (HP:0006709)	2.06011126
50	Sclerocornea (HP:0000647)	2.04234610
51	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.03907535
52	Stenosis of the external auditory canal (HP:0000402)	2.03460159
53	Tubular atrophy (HP:0000092)	2.02865002
54	Drooling (HP:0002307)	2.02483620
55	Barrel-shaped chest (HP:0001552)	2.01212465
56	Cystic liver disease (HP:0006706)	1.99280160
57	Generalized tonic-clonic seizures (HP:0002069)	1.97949833
58	Abnormal foot bone ossification (HP:0010675)	1.97690097
59	Hemivertebrae (HP:0002937)	1.97484703
60	Bile duct proliferation (HP:0001408)	1.97420324
61	Abnormal biliary tract physiology (HP:0012439)	1.97420324
62	Oculomotor apraxia (HP:0000657)	1.97235491
63	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.94293965
64	Hypoplastic iliac wings (HP:0002866)	1.94147893
65	Type II lissencephaly (HP:0007260)	1.93906903
66	Nephrogenic diabetes insipidus (HP:0009806)	1.93232555
67	Abnormality of the labia (HP:0000058)	1.92178105
68	Pancreatic islet-cell hyperplasia (HP:0004510)	1.91911736
69	Hyperventilation (HP:0002883)	1.90174003
70	Progressive inability to walk (HP:0002505)	1.88491387
71	Supernumerary spleens (HP:0009799)	1.88162787
72	Optic nerve coloboma (HP:0000588)	1.86426114
73	Focal seizures (HP:0007359)	1.86110989
74	Vitreoretinal degeneration (HP:0000655)	1.84868380
75	Abnormal lung lobation (HP:0002101)	1.83438646
76	Highly arched eyebrow (HP:0002553)	1.81533683
77	Dandy-Walker malformation (HP:0001305)	1.79678943
78	Excessive salivation (HP:0003781)	1.79594299
79	Rib fusion (HP:0000902)	1.79055884
80	Pachygyria (HP:0001302)	1.77869638
81	Anencephaly (HP:0002323)	1.77362990
82	Aqueductal stenosis (HP:0002410)	1.76940133
83	Hip dysplasia (HP:0001385)	1.76802157
84	Decreased lacrimation (HP:0000633)	1.76084642
85	Broad-based gait (HP:0002136)	1.75835302
86	Hemiparesis (HP:0001269)	1.75572629
87	Occipital encephalocele (HP:0002085)	1.75368979
88	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	1.74282176
89	Short 4th metacarpal (HP:0010044)	1.74282176
90	Facial hemangioma (HP:0000329)	1.73063900
91	Poor coordination (HP:0002370)	1.72300500
92	Polydipsia (HP:0001959)	1.71298423
93	Abnormal drinking behavior (HP:0030082)	1.71298423
94	Anophthalmia (HP:0000528)	1.69417329
95	Median cleft lip (HP:0000161)	1.69304451
96	Irregular epiphyses (HP:0010582)	1.69262326
97	Narrow forehead (HP:0000341)	1.69136214
98	Sex reversal (HP:0012245)	1.68893935
99	Abnormal sex determination (HP:0012244)	1.68893935
100	Coronal craniosynostosis (HP:0004440)	1.68701303

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TNIK	3.60037148
2	WEE1	3.50266832
3	WNK3	3.34452381
4	DYRK3	3.18751614
5	FRK	3.07956326
6	INSRR	2.99301037
7	RPS6KA4	2.70291823
8	BRSK2	2.62907583
9	BMPR1B	2.45637936
10	KSR1	2.28429572
11	STK39	2.02915981
12	MAP4K2	2.02770056
13	NTRK3	1.98524033
14	BCR	1.87091043
15	TRIM28	1.81500678
16	MKNK2	1.56132767
17	MAPK13	1.54874090
18	MAP3K2	1.53698960
19	CASK	1.53409198
20	ADRBK2	1.45306056
21	KSR2	1.44334568
22	NUAK1	1.42405961
23	RAF1	1.39665907
24	MKNK1	1.38786918
25	DYRK2	1.32828050
26	EPHB2	1.31695726
27	CDK3	1.30239133
28	ERBB3	1.27709657
29	BRSK1	1.27426516
30	STK16	1.27398786
31	ACVR1B	1.23040698
32	PNCK	1.21822806
33	PLK3	1.20802307
34	PKN1	1.18927474
35	TGFBR1	1.18879565
36	GRK1	1.16997762
37	PAK3	1.14198819
38	PTK2B	1.12858873
39	SRPK1	1.10684363
40	NLK	1.08657579
41	EPHA4	1.07637804
42	OXSR1	1.06780817
43	PRKCE	1.05587252
44	ZAK	1.05530835
45	PLK4	1.02766064
46	CAMK4	1.02619627
47	FGFR2	1.01924314
48	MAP3K10	0.88795134
49	MAP3K8	0.84242613
50	PINK1	0.84025452
51	FGFR1	0.82643285
52	SGK2	0.82444568
53	PLK2	0.79390987
54	ERBB2	0.77114231
55	MINK1	0.77068360
56	NEK6	0.73644483
57	GRK6	0.73205423
58	CDC7	0.68051980
59	CAMKK2	0.67905699
60	CCNB1	0.66910857
61	NEK1	0.66906941
62	WNK4	0.65731814
63	CDK19	0.64322425
64	CAMK1G	0.61160407
65	CHEK2	0.60084245
66	MAP3K4	0.58323503
67	CSNK1G2	0.54972977
68	CSNK1G1	0.52911835
69	LIMK1	0.52887161
70	CAMK2B	0.52171026
71	ATR	0.51570184
72	PRKCG	0.49957822
73	CAMK1D	0.49425337
74	PLK1	0.48927744
75	ATM	0.48758012
76	FLT3	0.48693183
77	SGK223	0.46613381
78	SGK494	0.46613381
79	GRK5	0.45018140
80	ROCK1	0.44626838
81	FER	0.44426652
82	MAP3K7	0.42670070
83	CDK6	0.41950950
84	CAMK2D	0.41710079
85	PIK3CA	0.40994994
86	EIF2AK2	0.40980097
87	TIE1	0.40868233
88	AURKB	0.40050339
89	BCKDK	0.38412048
90	DDR2	0.38196511
91	TLK1	0.37988311
92	CSNK1A1	0.37529881
93	HIPK2	0.37487135
94	BUB1	0.37302499
95	MARK3	0.36267263
96	EIF2AK3	0.35012812
97	CAMK2A	0.33807627
98	PASK	0.33723960
99	EPHA3	0.33581613
100	RPS6KA5	0.32939169

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	4.17678171
2	Protein export_Homo sapiens_hsa03060	3.22626789
3	Fatty acid elongation_Homo sapiens_hsa00062	3.04079975
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.60829953
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.59234026
6	Basal cell carcinoma_Homo sapiens_hsa05217	2.41487195
7	Phototransduction_Homo sapiens_hsa04744	2.28366641
8	Fanconi anemia pathway_Homo sapiens_hsa03460	2.25284569
9	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.19534511
10	Butanoate metabolism_Homo sapiens_hsa00650	2.11318543
11	Steroid biosynthesis_Homo sapiens_hsa00100	2.09214007
12	Propanoate metabolism_Homo sapiens_hsa00640	2.05567884
13	Hedgehog signaling pathway_Homo sapiens_hsa04340	2.02116332
14	Nicotine addiction_Homo sapiens_hsa05033	1.77002585
15	Homologous recombination_Homo sapiens_hsa03440	1.73313324
16	Basal transcription factors_Homo sapiens_hsa03022	1.71181525
17	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.67342668
18	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.65498432
19	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.58894977
20	Non-homologous end-joining_Homo sapiens_hsa03450	1.57498852
21	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.50671241
22	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.42638301
23	Selenocompound metabolism_Homo sapiens_hsa00450	1.32195723
24	p53 signaling pathway_Homo sapiens_hsa04115	1.25566547
25	Fatty acid metabolism_Homo sapiens_hsa01212	1.25339055
26	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.23096505
27	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.17512357
28	Hippo signaling pathway_Homo sapiens_hsa04390	1.15749894
29	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.11074486
30	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.10975509
31	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.09599875
32	RNA degradation_Homo sapiens_hsa03018	1.08949914
33	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.08604358
34	Melanogenesis_Homo sapiens_hsa04916	1.07120445
35	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.06985040
36	Linoleic acid metabolism_Homo sapiens_hsa00591	1.06175815
37	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.05764138
38	Cell cycle_Homo sapiens_hsa04110	1.00374889
39	Nitrogen metabolism_Homo sapiens_hsa00910	1.00041273
40	Olfactory transduction_Homo sapiens_hsa04740	0.94317139
41	Circadian entrainment_Homo sapiens_hsa04713	0.94223392
42	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.94156457
43	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.93697887
44	ECM-receptor interaction_Homo sapiens_hsa04512	0.92078456
45	Oocyte meiosis_Homo sapiens_hsa04114	0.91251107
46	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.89869298
47	Fatty acid degradation_Homo sapiens_hsa00071	0.89614544
48	Cocaine addiction_Homo sapiens_hsa05030	0.88945216
49	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.88609388
50	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.86071872
51	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.85290655
52	GABAergic synapse_Homo sapiens_hsa04727	0.83273441
53	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.81996914
54	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.80952303
55	Melanoma_Homo sapiens_hsa05218	0.80878062
56	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.80651106
57	Ether lipid metabolism_Homo sapiens_hsa00565	0.79053121
58	Morphine addiction_Homo sapiens_hsa05032	0.78507304
59	Retinol metabolism_Homo sapiens_hsa00830	0.77258239
60	Tryptophan metabolism_Homo sapiens_hsa00380	0.77221184
61	Peroxisome_Homo sapiens_hsa04146	0.76855996
62	Chemical carcinogenesis_Homo sapiens_hsa05204	0.76848661
63	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.76384342
64	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.75957197
65	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.75895047
66	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.75193814
67	Lysine degradation_Homo sapiens_hsa00310	0.72469102
68	Taste transduction_Homo sapiens_hsa04742	0.69209791
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.68807322
70	Wnt signaling pathway_Homo sapiens_hsa04310	0.68674418
71	Axon guidance_Homo sapiens_hsa04360	0.67677095
72	Pyruvate metabolism_Homo sapiens_hsa00620	0.67488877
73	Prostate cancer_Homo sapiens_hsa05215	0.65610491
74	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.64779631
75	Serotonergic synapse_Homo sapiens_hsa04726	0.64737220
76	RNA transport_Homo sapiens_hsa03013	0.64263994
77	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.57973869
78	Nucleotide excision repair_Homo sapiens_hsa03420	0.56807703
79	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.55884289
80	Circadian rhythm_Homo sapiens_hsa04710	0.55721693
81	RNA polymerase_Homo sapiens_hsa03020	0.54527499
82	Purine metabolism_Homo sapiens_hsa00230	0.54260218
83	Protein digestion and absorption_Homo sapiens_hsa04974	0.54163213
84	Glutamatergic synapse_Homo sapiens_hsa04724	0.53956427
85	Cholinergic synapse_Homo sapiens_hsa04725	0.53871674
86	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.50878751
87	Arginine and proline metabolism_Homo sapiens_hsa00330	0.50837980
88	Dopaminergic synapse_Homo sapiens_hsa04728	0.50268776
89	Fat digestion and absorption_Homo sapiens_hsa04975	0.49823383
90	Huntingtons disease_Homo sapiens_hsa05016	0.46919671
91	Glutathione metabolism_Homo sapiens_hsa00480	0.46799899
92	Metabolic pathways_Homo sapiens_hsa01100	0.40810743
93	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.40643848
94	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.39978520
95	beta-Alanine metabolism_Homo sapiens_hsa00410	0.38096219
96	Pathways in cancer_Homo sapiens_hsa05200	0.37679905
97	Pyrimidine metabolism_Homo sapiens_hsa00240	0.30862539
98	Insulin secretion_Homo sapiens_hsa04911	0.30629700
99	MicroRNAs in cancer_Homo sapiens_hsa05206	0.30376574
100	Adherens junction_Homo sapiens_hsa04520	0.28642084

MRPS21P8

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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