MRPS23

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 7p. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.60729728
2ATP synthesis coupled proton transport (GO:0015986)5.30991352
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.30991352
4tricarboxylic acid cycle (GO:0006099)5.20577222
5oxidative phosphorylation (GO:0006119)5.08148944
6ribosomal small subunit assembly (GO:0000028)4.78272801
7chaperone-mediated protein transport (GO:0072321)4.70550492
8sarcomere organization (GO:0045214)4.68967060
9establishment of protein localization to mitochondrial membrane (GO:0090151)4.62706455
10respiratory electron transport chain (GO:0022904)4.47021299
11electron transport chain (GO:0022900)4.34859086
12viral transcription (GO:0019083)4.32127147
13mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.32080316
14translational termination (GO:0006415)4.21563368
15formation of translation preinitiation complex (GO:0001731)4.13896986
16maturation of SSU-rRNA (GO:0030490)4.13696901
17translational elongation (GO:0006414)4.05254126
18regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.99342714
19water-soluble vitamin biosynthetic process (GO:0042364)3.93804873
20termination of RNA polymerase III transcription (GO:0006386)3.89108083
21transcription elongation from RNA polymerase III promoter (GO:0006385)3.89108083
22NADH metabolic process (GO:0006734)3.88793391
23exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.83904887
24actin-myosin filament sliding (GO:0033275)3.82505389
25muscle filament sliding (GO:0030049)3.82505389
26respiratory chain complex IV assembly (GO:0008535)3.81729278
27SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.80768596
28nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.80663633
29proteasome assembly (GO:0043248)3.71927418
30translational initiation (GO:0006413)3.71324115
31heart contraction (GO:0060047)3.71001085
32heart process (GO:0003015)3.71001085
33protein targeting to ER (GO:0045047)3.69797434
34regulation of mitochondrial translation (GO:0070129)3.69756494
35L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.69486208
36cotranslational protein targeting to membrane (GO:0006613)3.69430408
37pseudouridine synthesis (GO:0001522)3.68761700
38rRNA methylation (GO:0031167)3.64423864
39tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.61523405
40RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.61523405
41ribosomal small subunit biogenesis (GO:0042274)3.60500674
42cardiac myofibril assembly (GO:0055003)3.59605567
43protein targeting to mitochondrion (GO:0006626)3.57189308
44DNA deamination (GO:0045006)3.56855643
45protein neddylation (GO:0045116)3.56626577
46establishment of protein localization to endoplasmic reticulum (GO:0072599)3.55767591
47ribosomal large subunit biogenesis (GO:0042273)3.55583795
48regulation of acyl-CoA biosynthetic process (GO:0050812)3.53844251
49protein localization to endoplasmic reticulum (GO:0070972)3.50690639
50quinone biosynthetic process (GO:1901663)3.50486432
51ubiquinone biosynthetic process (GO:0006744)3.50486432
52regulation of coenzyme metabolic process (GO:0051196)3.44745986
53regulation of cofactor metabolic process (GO:0051193)3.44745986
54cytochrome complex assembly (GO:0017004)3.42910964
55rRNA processing (GO:0006364)3.39683721
56* translation (GO:0006412)3.39378109
57nucleobase biosynthetic process (GO:0046112)3.38502249
58negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.37417795
59establishment of protein localization to mitochondrion (GO:0072655)3.36101737
60viral life cycle (GO:0019058)3.36082591
61purine nucleobase biosynthetic process (GO:0009113)3.34441447
62cellular protein complex disassembly (GO:0043624)3.32223737
63protein localization to mitochondrion (GO:0070585)3.31798463
64chromatin remodeling at centromere (GO:0031055)3.30299004
65nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.29084804
66negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.28353552
67rRNA metabolic process (GO:0016072)3.26625881
68CENP-A containing nucleosome assembly (GO:0034080)3.22669203
69positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.20415621
70mitochondrial respiratory chain complex assembly (GO:0033108)3.19383306
71myofibril assembly (GO:0030239)3.18540682
72DNA strand elongation involved in DNA replication (GO:0006271)3.18332815
73ribosome assembly (GO:0042255)3.17481912
74mitochondrial respiratory chain complex I assembly (GO:0032981)3.17137390
75NADH dehydrogenase complex assembly (GO:0010257)3.17137390
76mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.17137390
77ribonucleoprotein complex biogenesis (GO:0022613)3.16394656
78maturation of 5.8S rRNA (GO:0000460)3.16153548
79regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.13931453
80cardiac muscle cell development (GO:0055013)3.11145202
81anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.10551651
82telomere maintenance via semi-conservative replication (GO:0032201)3.09936055
83peptidyl-histidine modification (GO:0018202)3.08599922
84spliceosomal snRNP assembly (GO:0000387)3.08018814
85DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.06020704
86regulation of cellular amino acid metabolic process (GO:0006521)3.05723238
87ATP biosynthetic process (GO:0006754)3.03859815
88DNA damage response, detection of DNA damage (GO:0042769)3.03586115
89mitochondrial RNA metabolic process (GO:0000959)3.03328428
90protein complex biogenesis (GO:0070271)3.03156398
91DNA strand elongation (GO:0022616)3.02723184
92transcription from mitochondrial promoter (GO:0006390)3.02028425
93negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.01980888
94negative regulation of ligase activity (GO:0051352)3.01980888
95purine nucleoside triphosphate biosynthetic process (GO:0009145)3.00235444
96tRNA processing (GO:0008033)2.99460537
97signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.99394939
98intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.99394939
99purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.97666780
100L-methionine salvage (GO:0071267)2.97066371
101L-methionine biosynthetic process (GO:0071265)2.97066371
102amino acid salvage (GO:0043102)2.97066371
103positive regulation of ligase activity (GO:0051351)2.96508254
104signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.96162976
105signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.96162976
106signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.96162976
107ubiquinone metabolic process (GO:0006743)2.95626538
108behavioral response to nicotine (GO:0035095)2.94909028
109inner mitochondrial membrane organization (GO:0007007)2.94295904
110cellular component biogenesis (GO:0044085)2.94230758
111DNA replication checkpoint (GO:0000076)2.93993939
112signal transduction involved in DNA integrity checkpoint (GO:0072401)2.93772542
113signal transduction involved in DNA damage checkpoint (GO:0072422)2.93772542
114aerobic respiration (GO:0009060)2.93027883
115ribosome biogenesis (GO:0042254)2.92973390
116antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.91408770
117intracellular protein transmembrane import (GO:0044743)2.91317266
118regulation of relaxation of muscle (GO:1901077)2.90412599
119positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.89591981
120actin-mediated cell contraction (GO:0070252)2.89022693
121protein complex disassembly (GO:0043241)2.88413065
122purine nucleoside monophosphate biosynthetic process (GO:0009127)2.88365086
123purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.88365086
124signal transduction involved in cell cycle checkpoint (GO:0072395)2.87972102
125histone exchange (GO:0043486)2.87902087
126tRNA metabolic process (GO:0006399)2.87573241
127protein deneddylation (GO:0000338)2.87457180
128oxaloacetate metabolic process (GO:0006107)2.87189368
129cardiac cell development (GO:0055006)2.86903174
130positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.86052992
131negative regulation of potassium ion transmembrane transport (GO:1901380)2.84963036
132cullin deneddylation (GO:0010388)2.84252316
133protein-cofactor linkage (GO:0018065)2.84118356
134ncRNA processing (GO:0034470)2.82751860
135ncRNA metabolic process (GO:0034660)2.82748536
136nucleobase-containing small molecule interconversion (GO:0015949)2.82529720
137rRNA modification (GO:0000154)2.82523627
138cardiac muscle contraction (GO:0060048)2.81970962
139macromolecular complex disassembly (GO:0032984)2.81898565
140replication fork processing (GO:0031297)2.81314019
141GTP biosynthetic process (GO:0006183)2.81161963
142pteridine-containing compound biosynthetic process (GO:0042559)2.78977292
143ribonucleoside triphosphate biosynthetic process (GO:0009201)2.78098231
144regulation of ubiquitin-protein transferase activity (GO:0051438)2.78014854

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.31070925
2E2F7_22180533_ChIP-Seq_HELA_Human4.29031583
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.92396249
4* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.48728247
5* GABP_17652178_ChIP-ChIP_JURKAT_Human3.25736606
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.24787426
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.07279069
8* ETS1_20019798_ChIP-Seq_JURKAT_Human3.06691324
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.05579611
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.77679553
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.76141480
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.72245787
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.60560891
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.58115437
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.57122521
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.53572007
17XRN2_22483619_ChIP-Seq_HELA_Human2.24096503
18* VDR_23849224_ChIP-Seq_CD4+_Human2.23385957
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.17170528
20DCP1A_22483619_ChIP-Seq_HELA_Human2.16782519
21* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.15701724
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.14079650
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.12276868
24E2F4_17652178_ChIP-ChIP_JURKAT_Human2.06885433
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.05627909
26SRF_21415370_ChIP-Seq_HL-1_Mouse2.02765263
27* FOXP3_21729870_ChIP-Seq_TREG_Human1.96668500
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.94087546
29* GABP_19822575_ChIP-Seq_HepG2_Human1.92513449
30FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.91456394
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.89618240
32TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88310022
33MYC_18940864_ChIP-ChIP_HL60_Human1.87886215
34PADI4_21655091_ChIP-ChIP_MCF-7_Human1.85197236
35FOXM1_23109430_ChIP-Seq_U2OS_Human1.83267710
36* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.82006814
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.80640631
38* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79836819
39SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.75284975
40ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.73188118
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.72966169
42E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.70611437
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.68566630
44ZFX_18555785_ChIP-Seq_MESCs_Mouse1.67490175
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.67048659
46* TTF2_22483619_ChIP-Seq_HELA_Human1.66320847
47ZNF274_21170338_ChIP-Seq_K562_Hela1.66204064
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.64723408
49CIITA_25753668_ChIP-Seq_RAJI_Human1.64390313
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.59805795
51BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.55330705
52PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.54509439
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53182439
54VDR_22108803_ChIP-Seq_LS180_Human1.52244406
55STAT3_1855785_ChIP-Seq_MESCs_Mouse1.51204139
56MYCN_18555785_ChIP-Seq_MESCs_Mouse1.51130362
57EWS_26573619_Chip-Seq_HEK293_Human1.49620879
58* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.49381114
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.46594999
60TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.45613757
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.45517233
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42649675
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.41921558
64MYC_22102868_ChIP-Seq_BL_Human1.40973094
65ELK1_19687146_ChIP-ChIP_HELA_Human1.39471504
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.39292353
67AR_21909140_ChIP-Seq_LNCAP_Human1.37637169
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.37012491
69YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36280530
70* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35646399
71FUS_26573619_Chip-Seq_HEK293_Human1.30129863
72TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29710435
73NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26021754
74KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24572619
75KDM5A_27292631_Chip-Seq_BREAST_Human1.21925907
76MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.19518048
77* E2F1_21310950_ChIP-Seq_MCF-7_Human1.18224152
78CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.17561372
79KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.16924878
80IRF1_19129219_ChIP-ChIP_H3396_Human1.14887271
81ZNF263_19887448_ChIP-Seq_K562_Human1.13017816
82TFEB_21752829_ChIP-Seq_HELA_Human1.12075827
83* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.12005509
84POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11390699
85GATA4_21415370_ChIP-Seq_HL-1_Mouse1.10447267
86* ELK1_22589737_ChIP-Seq_MCF10A_Human1.10443243
87NANOG_16153702_ChIP-ChIP_HESCs_Human1.09290724
88VDR_21846776_ChIP-Seq_THP-1_Human1.07866754
89* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07523189
90TBX5_21415370_ChIP-Seq_HL-1_Mouse1.04658161
91EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03009425
92DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01347682
93HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.01337840
94SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.00743564
95NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.00474660
96POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99892218
97SPI1_23547873_ChIP-Seq_NB4_Human0.99578920
98* SOX2_16153702_ChIP-ChIP_HESCs_Human0.98393939
99MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.96817556
100ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95094628
101MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.94406456
102* SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94289363
103SALL1_21062744_ChIP-ChIP_HESCs_Human0.93961855
104NOTCH1_21737748_ChIP-Seq_TLL_Human0.92878592
105* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.92153611
106GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91566741
107E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91279319
108GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90702888
109FLI1_27457419_Chip-Seq_LIVER_Mouse0.90335265
110TP53_22573176_ChIP-Seq_HFKS_Human0.89340618
111ATF3_27146783_Chip-Seq_COLON_Human0.88999796
112YY1_22570637_ChIP-Seq_MALME-3M_Human0.86663472
113MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.85664848
114CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.85598110
115TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84760051
116SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.84672608
117SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.84212938
118* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.84069509
119SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.83931769
120SRY_22984422_ChIP-ChIP_TESTIS_Rat0.83522096
121* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.83412643
122RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.83058914
123* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.81937740
124CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.81285054
125TP63_19390658_ChIP-ChIP_HaCaT_Human0.76700802
126GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.75825737
127SOX17_20123909_ChIP-Seq_XEN_Mouse0.73614100
128* ELF5_23300383_ChIP-Seq_T47D_Human0.71301260
129NCOR_22424771_ChIP-Seq_293T_Human0.70678945
130AUTS2_25519132_ChIP-Seq_293T-REX_Human0.69835196
131KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.69182219
132BMI1_23680149_ChIP-Seq_NPCS_Mouse0.69042556
133* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.68561045
134IGF1R_20145208_ChIP-Seq_DFB_Human0.68557753
135TAF15_26573619_Chip-Seq_HEK293_Human0.67861985
136* FOXP1_21924763_ChIP-Seq_HESCs_Human0.67663409

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.72613271
2MP0002837_dystrophic_cardiac_calcinosis4.53254778
3MP0004084_abnormal_cardiac_muscle4.39303461
4MP0004215_abnormal_myocardial_fiber3.24414538
5MP0005330_cardiomyopathy3.17471431
6MP0000749_muscle_degeneration3.14294912
7MP0000751_myopathy3.09550404
8MP0004036_abnormal_muscle_relaxation3.09061619
9MP0006292_abnormal_olfactory_placode3.03001368
10MP0003693_abnormal_embryo_hatching2.95246414
11MP0006036_abnormal_mitochondrial_physio2.88505225
12MP0003221_abnormal_cardiomyocyte_apopto2.65189715
13MP0004957_abnormal_blastocyst_morpholog2.44772416
14MP0003806_abnormal_nucleotide_metabolis2.37498191
15MP0008775_abnormal_heart_ventricle2.37060001
16MP0000750_abnormal_muscle_regeneration2.32990044
17MP0004087_abnormal_muscle_fiber2.29233215
18MP0008877_abnormal_DNA_methylation2.27712664
19MP0002269_muscular_atrophy2.23248968
20MP0002972_abnormal_cardiac_muscle2.19118754
21MP0005385_cardiovascular_system_phenoty2.09465802
22MP0001544_abnormal_cardiovascular_syste2.09465802
23MP0002106_abnormal_muscle_physiology2.04336833
24MP0002160_abnormal_reproductive_system1.99838778
25MP0003567_abnormal_fetal_cardiomyocyte1.96502657
26MP0006035_abnormal_mitochondrial_morpho1.95189004
27MP0003077_abnormal_cell_cycle1.91938026
28MP0002102_abnormal_ear_morphology1.88845171
29MP0001529_abnormal_vocalization1.84769159
30MP0010630_abnormal_cardiac_muscle1.83993009
31MP0004484_altered_response_of1.82690681
32MP0000747_muscle_weakness1.80995685
33MP0010094_abnormal_chromosome_stability1.80489043
34MP0003111_abnormal_nucleus_morphology1.77325279
35MP0005620_abnormal_muscle_contractility1.76946853
36MP0004130_abnormal_muscle_cell1.72940860
37MP0002938_white_spotting1.72159303
38MP0000372_irregular_coat_pigmentation1.71840200
39MP0003137_abnormal_impulse_conducting1.71630593
40MP0008789_abnormal_olfactory_epithelium1.71329533
41MP0003186_abnormal_redox_activity1.65869144
42MP0005646_abnormal_pituitary_gland1.61705592
43MP0008872_abnormal_physiological_respon1.57975844
44MP0002163_abnormal_gland_morphology1.57722659
45MP0004145_abnormal_muscle_electrophysio1.56395307
46MP0000049_abnormal_middle_ear1.54844277
47MP0004142_abnormal_muscle_tone1.50539640
48MP0006072_abnormal_retinal_apoptosis1.50487929
49MP0000759_abnormal_skeletal_muscle1.50163246
50MP0005369_muscle_phenotype1.50015547
51MP0002736_abnormal_nociception_after1.47181496
52MP0009697_abnormal_copulation1.39884589
53MP0005379_endocrine/exocrine_gland_phen1.38849737
54MP0005389_reproductive_system_phenotype1.38707164
55MP0006138_congestive_heart_failure1.34769842
56MP0005408_hypopigmentation1.34492544
57MP0003937_abnormal_limbs/digits/tail_de1.34353627
58MP0009046_muscle_twitch1.34052738
59MP0008932_abnormal_embryonic_tissue1.31704572
60MP0001968_abnormal_touch/_nociception1.31326276
61MP0004133_heterotaxia1.30888046
62MP0003828_pulmonary_edema1.30757483
63MP0000343_altered_response_to1.29570116
64MP0001485_abnormal_pinna_reflex1.29514483
65MP0005084_abnormal_gallbladder_morpholo1.27537822
66MP0003880_abnormal_central_pattern1.27411977
67MP0001293_anophthalmia1.27258638
68MP0001730_embryonic_growth_arrest1.26167599
69MP0009333_abnormal_splenocyte_physiolog1.26080000
70MP0005551_abnormal_eye_electrophysiolog1.21877648
71MP0001853_heart_inflammation1.21570940
72MP0002210_abnormal_sex_determination1.20819886
73MP0008995_early_reproductive_senescence1.18844980
74MP0002876_abnormal_thyroid_physiology1.18373064
75MP0005451_abnormal_body_composition1.17881915
76MP0004233_abnormal_muscle_weight1.17682158
77MP0005410_abnormal_fertilization1.16996973
78MP0002638_abnormal_pupillary_reflex1.16694976
79MP0000358_abnormal_cell_content/1.15978089
80MP0000631_abnormal_neuroendocrine_gland1.15568275
81MP0008875_abnormal_xenobiotic_pharmacok1.15370150
82MP0003011_delayed_dark_adaptation1.15366641
83MP0004147_increased_porphyrin_level1.14415637
84MP0002396_abnormal_hematopoietic_system1.14298591
85MP0004510_myositis1.13375476
86MP0005499_abnormal_olfactory_system1.12767366
87MP0005394_taste/olfaction_phenotype1.12767366
88MP0001929_abnormal_gametogenesis1.11446227
89MP0003890_abnormal_embryonic-extraembry1.10016640
90MP0008057_abnormal_DNA_replication1.09754300
91MP0003136_yellow_coat_color1.09593380
92MP0003763_abnormal_thymus_physiology1.06974911
93MP0003123_paternal_imprinting1.06955448
94MP0009840_abnormal_foam_cell1.06837824
95MP0003787_abnormal_imprinting1.06258008
96MP0005266_abnormal_metabolism1.06149872
97MP0008007_abnormal_cellular_replicative1.04168383
98MP0002127_abnormal_cardiovascular_syste1.04132683
99MP0008058_abnormal_DNA_repair1.02918981
100MP0003121_genomic_imprinting1.01847815
101MP0005253_abnormal_eye_physiology1.01480697
102MP0005666_abnormal_adipose_tissue0.99781700
103MP0002751_abnormal_autonomic_nervous0.99364235
104MP0002332_abnormal_exercise_endurance0.99268652
105MP0001145_abnormal_male_reproductive0.99136371
106MP0003984_embryonic_growth_retardation0.98844864
107MP0001905_abnormal_dopamine_level0.97306143
108MP0000653_abnormal_sex_gland0.96365877
109MP0001919_abnormal_reproductive_system0.95665554
110MP0001697_abnormal_embryo_size0.95600475
111MP0002088_abnormal_embryonic_growth/wei0.95219074
112MP0000350_abnormal_cell_proliferation0.94904121
113MP0010030_abnormal_orbit_morphology0.94844200
114MP0002272_abnormal_nervous_system0.92842368
115MP0002234_abnormal_pharynx_morphology0.92210471
116MP0006276_abnormal_autonomic_nervous0.91639530
117MP0003950_abnormal_plasma_membrane0.91444611
118MP0003698_abnormal_male_reproductive0.91063744
119MP0000490_abnormal_crypts_of0.90931945
120MP0000266_abnormal_heart_morphology0.90661296
121MP0002080_prenatal_lethality0.89761917
122MP0003656_abnormal_erythrocyte_physiolo0.89379918
123MP0003119_abnormal_digestive_system0.88991293
124MP0009745_abnormal_behavioral_response0.88401329
125MP0003941_abnormal_skin_development0.88343678
126MP0000647_abnormal_sebaceous_gland0.88101359
127MP0004085_abnormal_heartbeat0.88057251
128MP0005380_embryogenesis_phenotype0.86270071
129MP0001672_abnormal_embryogenesis/_devel0.86270071
130MP0005319_abnormal_enzyme/_coenzyme0.84868454
131MP0000313_abnormal_cell_death0.84578837
132MP0001764_abnormal_homeostasis0.83527230
133MP0001286_abnormal_eye_development0.82893753
134MP0002019_abnormal_tumor_incidence0.82035513
135MP0003315_abnormal_perineum_morphology0.81089544
136MP0004043_abnormal_pH_regulation0.80865613
137MP0009379_abnormal_foot_pigmentation0.78933781
138MP0003786_premature_aging0.76125552
139MP0002184_abnormal_innervation0.76117781
140MP0000427_abnormal_hair_cycle0.75964812
141MP0003718_maternal_effect0.75941121
142MP0005670_abnormal_white_adipose0.75097164
143MP0002734_abnormal_mechanical_nocicepti0.74391963
144MP0002085_abnormal_embryonic_tissue0.71526264
145MP0005165_increased_susceptibility_to0.70999069
146MP0004185_abnormal_adipocyte_glucose0.70864187
147MP0005174_abnormal_tail_pigmentation0.69547531
148MP0005195_abnormal_posterior_eye0.69480076
149MP0003936_abnormal_reproductive_system0.69396320
150MP0002090_abnormal_vision0.69047867
151MP0010352_gastrointestinal_tract_polyps0.68601423
152MP0006054_spinal_hemorrhage0.68057702
153MP0002398_abnormal_bone_marrow0.67650202
154MP0002722_abnormal_immune_system0.67595356
155MP0002233_abnormal_nose_morphology0.67423320
156MP0002095_abnormal_skin_pigmentation0.66637684
157MP0002084_abnormal_developmental_patter0.66469825
158MP0005075_abnormal_melanosome_morpholog0.66230710
159MP0009643_abnormal_urine_homeostasis0.65912437
160MP0004808_abnormal_hematopoietic_stem0.65309060
161MP0000703_abnormal_thymus_morphology0.65008102
162MP0000689_abnormal_spleen_morphology0.63452621
163MP0002429_abnormal_blood_cell0.60089819
164MP0005584_abnormal_enzyme/coenzyme_acti0.59164426
165MP0002877_abnormal_melanocyte_morpholog0.55616204
166MP0000230_abnormal_systemic_arterial0.54974227
167MP0005332_abnormal_amino_acid0.53056110
168MP0003195_calcinosis0.52070944
169MP0002086_abnormal_extraembryonic_tissu0.48232763
170MP0002970_abnormal_white_adipose0.47119926
171MP0002933_joint_inflammation0.46967553
172MP0000716_abnormal_immune_system0.46775231
173MP0003566_abnormal_cell_adhesion0.46678579
174MP0002132_abnormal_respiratory_system0.46182182

Predicted human phenotypes

RankGene SetZ-score
1Hepatic necrosis (HP:0002605)4.93742216
2Hepatocellular necrosis (HP:0001404)4.61660185
3Abnormal mitochondria in muscle tissue (HP:0008316)4.47553752
4Acute necrotizing encephalopathy (HP:0006965)4.47209766
5Sudden death (HP:0001699)4.45479235
6Ventricular tachycardia (HP:0004756)4.28470241
7Mitochondrial inheritance (HP:0001427)4.26893538
8Exercise-induced muscle cramps (HP:0003710)4.22527622
9Rhabdomyolysis (HP:0003201)4.13471932
10Increased CSF lactate (HP:0002490)4.06303351
11Myoglobinuria (HP:0002913)4.00798699
12Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.97674565
13Decreased activity of mitochondrial respiratory chain (HP:0008972)3.97674565
14Acute encephalopathy (HP:0006846)3.80445381
15Muscle fiber splitting (HP:0003555)3.78346379
16Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.70213904
17Abnormality of alanine metabolism (HP:0010916)3.70213904
18Hyperalaninemia (HP:0003348)3.70213904
19Calf muscle hypertrophy (HP:0008981)3.69165474
20Increased muscle lipid content (HP:0009058)3.65173160
21Palpitations (HP:0001962)3.60552254
22Lipoatrophy (HP:0100578)3.57061501
23Increased intramyocellular lipid droplets (HP:0012240)3.55526089
24Progressive macrocephaly (HP:0004481)3.50044745
25Lipid accumulation in hepatocytes (HP:0006561)3.41526483
26Lactic acidosis (HP:0003128)3.41189395
27Muscle hypertrophy of the lower extremities (HP:0008968)3.37728463
28Exercise-induced myalgia (HP:0003738)3.36784587
29Increased serum lactate (HP:0002151)3.35183918
30Abnormality of glycolysis (HP:0004366)3.32730944
31Increased serum pyruvate (HP:0003542)3.32730944
32Exercise intolerance (HP:0003546)3.24436297
33Increased hepatocellular lipid droplets (HP:0006565)3.18263065
34Cerebral edema (HP:0002181)3.13977080
35Respiratory failure (HP:0002878)3.13021652
36Multiple enchondromatosis (HP:0005701)3.12599382
37Dilated cardiomyopathy (HP:0001644)3.12243809
38Atrial fibrillation (HP:0005110)3.08916651
39Abnormality of cells of the erythroid lineage (HP:0012130)3.08329414
403-Methylglutaconic aciduria (HP:0003535)3.07611199
41Abnormality of dicarboxylic acid metabolism (HP:0010995)3.04825657
42Dicarboxylic aciduria (HP:0003215)3.04825657
43Abnormal number of erythroid precursors (HP:0012131)2.98273491
44Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.98051591
45Supraventricular tachycardia (HP:0004755)2.97569637
46Supraventricular arrhythmia (HP:0005115)2.88633329
47Primary atrial arrhythmia (HP:0001692)2.87117178
48Generalized aminoaciduria (HP:0002909)2.82411330
49Abnormality of fatty-acid metabolism (HP:0004359)2.80621678
50Ragged-red muscle fibers (HP:0003200)2.78297166
51Hypoglycemic coma (HP:0001325)2.77837725
52Abnormality of the calf musculature (HP:0001430)2.74026100
53Nausea (HP:0002018)2.72523866
54Abnormality of the left ventricular outflow tract (HP:0011103)2.72438531
55Subaortic stenosis (HP:0001682)2.72438531
56Progressive muscle weakness (HP:0003323)2.70871387
57Pancreatic cysts (HP:0001737)2.65421984
58Chromosomal breakage induced by crosslinking agents (HP:0003221)2.62514067
59EMG: myopathic abnormalities (HP:0003458)2.60564781
60Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.60361470
61Muscle fiber inclusion bodies (HP:0100299)2.60266359
62Methylmalonic acidemia (HP:0002912)2.60086461
63Meckel diverticulum (HP:0002245)2.57960277
64Asymmetric septal hypertrophy (HP:0001670)2.55095939
65Hyporeflexia of lower limbs (HP:0002600)2.54116007
66Aplasia/Hypoplasia of the uvula (HP:0010293)2.50458795
67Abnormality of the ileum (HP:0001549)2.50243509
68Conjunctival hamartoma (HP:0100780)2.50047874
69Methylmalonic aciduria (HP:0012120)2.49432057
70Areflexia of lower limbs (HP:0002522)2.48015192
71Respiratory difficulties (HP:0002880)2.47324600
72Pendular nystagmus (HP:0012043)2.45906415
73Chromsome breakage (HP:0040012)2.45765543
74Right ventricular cardiomyopathy (HP:0011663)2.43938246
75Myotonia (HP:0002486)2.41778954
76Absent thumb (HP:0009777)2.41019040
77Exertional dyspnea (HP:0002875)2.40282095
78Pancreatic fibrosis (HP:0100732)2.39091900
79Reticulocytopenia (HP:0001896)2.38832856
80CNS demyelination (HP:0007305)2.38152889
81Aplasia/Hypoplasia of the sacrum (HP:0008517)2.35300598
82Nemaline bodies (HP:0003798)2.35069434
83Birth length less than 3rd percentile (HP:0003561)2.32402532
84Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.31963739
85Degeneration of anterior horn cells (HP:0002398)2.30917298
86Abnormality of the anterior horn cell (HP:0006802)2.30917298
87Bundle branch block (HP:0011710)2.30253086
88Hypoplasia of the pons (HP:0012110)2.26329810
89Abnormality of the preputium (HP:0100587)2.25129709
90Hyperglycinemia (HP:0002154)2.24378189
91Optic disc pallor (HP:0000543)2.23663593
92Increased connective tissue (HP:0009025)2.21217661
93Type I transferrin isoform profile (HP:0003642)2.20865761
94Testicular atrophy (HP:0000029)2.19930466
95Molar tooth sign on MRI (HP:0002419)2.19686083
96Abnormality of midbrain morphology (HP:0002418)2.19686083
97Abnormality of serum amino acid levels (HP:0003112)2.18386062
98True hermaphroditism (HP:0010459)2.16013275
99Abnormality of the pons (HP:0007361)2.15914776
100Lethargy (HP:0001254)2.14108246
101Syncope (HP:0001279)2.13971927
102Abnormality of chromosome stability (HP:0003220)2.13539747
103Neoplasm of the adrenal gland (HP:0100631)2.13214017
104Colon cancer (HP:0003003)2.11870904
105Muscle stiffness (HP:0003552)2.11861610
106Ventricular arrhythmia (HP:0004308)2.10539589
107Difficulty climbing stairs (HP:0003551)2.08509174
108Limb-girdle muscle atrophy (HP:0003797)2.07808278
109Emotional lability (HP:0000712)2.06530082
110Congenital, generalized hypertrichosis (HP:0004540)2.06489108
111Abnormality of the labia minora (HP:0012880)2.05958396
112Short tibia (HP:0005736)2.00772240
113Esophageal neoplasm (HP:0100751)1.99158141
114Neoplasm of head and neck (HP:0012288)1.99158141
115Sclerocornea (HP:0000647)1.98403434
116Aplastic anemia (HP:0001915)1.96883051
117Aplasia/Hypoplasia of the tibia (HP:0005772)1.95976450
118Atrioventricular block (HP:0001678)1.95727970
119Leukodystrophy (HP:0002415)1.94839454
120Congenital stationary night blindness (HP:0007642)1.93431417
121Aplasia/hypoplasia of the uterus (HP:0008684)1.91058451
122Prolonged QT interval (HP:0001657)1.90302360
123Heart block (HP:0012722)1.89559943
124Microvesicular hepatic steatosis (HP:0001414)1.88634745
125Ketoacidosis (HP:0001993)1.87482847
126Cerebral hypomyelination (HP:0006808)1.86059159
127Abnormality of renal resorption (HP:0011038)1.84331530
128Ventricular fibrillation (HP:0001663)1.84286994
129Abnormality of methionine metabolism (HP:0010901)1.84242618
130Renal Fanconi syndrome (HP:0001994)1.83835695
131Horseshoe kidney (HP:0000085)1.83627680
132Macrocytic anemia (HP:0001972)1.82890846
133Abnormal protein glycosylation (HP:0012346)1.82493895
134Abnormal glycosylation (HP:0012345)1.82493895
135Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.82493895
136Abnormal protein N-linked glycosylation (HP:0012347)1.82493895
137Nephronophthisis (HP:0000090)1.82125220
138Abnormality of urine glucose concentration (HP:0011016)1.81087635
139Glycosuria (HP:0003076)1.81087635
140Abnormal atrioventricular conduction (HP:0005150)1.80743093
141Stenosis of the external auditory canal (HP:0000402)1.79460714
142Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.79254568
143Triphalangeal thumb (HP:0001199)1.78297686
144Pallor (HP:0000980)1.77468940
145Medial flaring of the eyebrow (HP:0010747)1.75333311
146Pancytopenia (HP:0001876)1.73754864
147Abnormality of aspartate family amino acid metabolism (HP:0010899)1.71220485
148X-linked dominant inheritance (HP:0001423)1.69839908
149Adrenal hypoplasia (HP:0000835)1.69579584
150Type II lissencephaly (HP:0007260)1.68866274
151Duodenal stenosis (HP:0100867)1.68516737
152Small intestinal stenosis (HP:0012848)1.68516737
153CNS hypomyelination (HP:0003429)1.65198562
154Cleft eyelid (HP:0000625)1.64645132
155Reduced antithrombin III activity (HP:0001976)1.64554228
156Abnormal rod and cone electroretinograms (HP:0008323)1.64334056
157Abnormal lung lobation (HP:0002101)1.63965566

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.15200249
2VRK23.73097363
3BCKDK3.38013173
4PKN23.37553315
5PBK3.15284312
6EIF2AK13.12126776
7TTN3.11291979
8NEK13.10094552
9BUB12.82803007
10MST42.59667865
11TRIB32.57395878
12OBSCN2.55730505
13WEE12.35880005
14PDK42.34403272
15PDK32.34403272
16MYLK2.25729148
17TRIM281.84966917
18PLK31.84165595
19FRK1.84053137
20MAP2K31.82905496
21NME11.80158985
22BMPR1B1.74535509
23NUAK11.72996884
24GRK11.67661505
25TESK21.66826539
26MAP4K21.64405425
27ILK1.62004598
28PHKG11.60457741
29PHKG21.60457741
30STK241.58621988
31PDK21.57864028
32MAP4K11.55290368
33TAF11.50877077
34WNK31.41578375
35MKNK21.38991355
36EIF2AK31.38598137
37STK161.36159596
38TSSK61.36100510
39MAP3K111.35611147
40TESK11.35048185
41CDC71.27436549
42FLT31.27240332
43WNK41.26546786
44KDR1.25916864
45LMTK21.22021672
46ADRBK21.20383936
47LRRK21.19950160
48ZAP701.19078521
49MUSK1.16895047
50MAP3K91.16340201
51LIMK11.14727803
52RPS6KA41.14051144
53TLK11.09833342
54DYRK21.08968947
55RPS6KB21.08027665
56MAPKAPK31.06245618
57PIM21.06234119
58ZAK1.06025073
59STK38L1.05626621
60SCYL21.05541217
61PLK21.05256746
62STK41.03961166
63STK391.03118643
64VRK11.01574135
65ATR1.01452625
66CHEK20.99438330
67SRPK10.99242715
68MKNK10.98592707
69DYRK30.96311205
70AURKB0.96120219
71MAP3K30.95163548
72CCNB10.91742316
73INSRR0.88008225
74MAP3K50.87897167
75BRSK20.85887165
76MAP2K70.84569993
77NEK20.83516224
78MAP2K60.83425695
79EIF2AK20.83206575
80OXSR10.82144438
81PIK3CA0.78723439
82NEK90.77090833
83CSNK1G10.76247000
84CSNK1G30.76239556
85PAK40.75993775
86PLK10.75181876
87ARAF0.74718207
88CDK40.73944984
89TGFBR10.73601444
90PRKCI0.73560491
91MAP3K80.72889536
92EEF2K0.70544417
93DMPK0.67648690
94TTK0.67170583
95IRAK40.66866568
96AURKA0.66778618
97TNIK0.66605807
98ACVR1B0.65269655
99DAPK10.64644766
100PNCK0.63882004
101BRSK10.63632783
102PRKCG0.63568231
103CSNK1G20.63504789
104PASK0.63355591
105PINK10.63159370
106TAOK20.61141331
107ERBB30.60399686
108TIE10.59087930
109CHEK10.58833738
110RPS6KA50.58683636
111MAP3K40.58024016
112PLK40.57942584
113STK100.57235204
114BTK0.55893260
115CSNK1A1L0.55421911
116TYK20.53430836
117IRAK30.52896217
118ATM0.52776080
119CDK70.51655184
120CDK80.51073319
121BRAF0.51058491
122RPS6KC10.48263857
123RPS6KL10.48263857
124TBK10.47949790
125TEC0.47895439
126CSNK1E0.47504213
127DAPK30.47375123
128RPS6KA60.47229789
129BCR0.42272733
130PRKD10.41675525
131MAP3K120.41155656
132CSNK1A10.40422077
133CSNK2A10.40401688
134EPHA20.40214740
135MAPKAPK50.39215327
136PAK10.39073695
137ALK0.36805870
138MAPK110.36778769
139ABL20.36489434
140MINK10.36444465
141CSNK2A20.35815347
142CASK0.35769544
143ERBB40.35043270
144TAOK10.34213384
145PRKCE0.34113516
146MAP3K100.33913568
147NLK0.33340333
148PIM10.32163201
149CDK10.31830124
150MARK30.31750244
151AKT20.31314193
152ADRBK10.29643718

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.62512288
2Ribosome_Homo sapiens_hsa030103.74934330
3Proteasome_Homo sapiens_hsa030503.69541252
4Parkinsons disease_Homo sapiens_hsa050123.53709449
5Oxidative phosphorylation_Homo sapiens_hsa001903.41263393
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.10472965
7DNA replication_Homo sapiens_hsa030303.02650862
8RNA polymerase_Homo sapiens_hsa030202.67805824
9Huntingtons disease_Homo sapiens_hsa050162.44267249
10Mismatch repair_Homo sapiens_hsa034302.27298677
11Carbon metabolism_Homo sapiens_hsa012002.24473223
12Cardiac muscle contraction_Homo sapiens_hsa042602.23393003
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.18762863
14Alzheimers disease_Homo sapiens_hsa050102.14303354
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.08641789
16Propanoate metabolism_Homo sapiens_hsa006402.01481268
17Pyrimidine metabolism_Homo sapiens_hsa002401.93921288
18Base excision repair_Homo sapiens_hsa034101.84845190
19RNA transport_Homo sapiens_hsa030131.77188754
20Spliceosome_Homo sapiens_hsa030401.74892979
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.70156034
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.66448531
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.65310324
24Nucleotide excision repair_Homo sapiens_hsa034201.57060004
25Homologous recombination_Homo sapiens_hsa034401.56198558
26Fatty acid degradation_Homo sapiens_hsa000711.51293169
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.46388807
28Pyruvate metabolism_Homo sapiens_hsa006201.46294441
29Biosynthesis of amino acids_Homo sapiens_hsa012301.45697747
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.38757645
31Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.35374582
32Protein export_Homo sapiens_hsa030601.29082078
33Pentose phosphate pathway_Homo sapiens_hsa000301.23347022
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.18196110
35Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.13341687
36Purine metabolism_Homo sapiens_hsa002301.12696713
37One carbon pool by folate_Homo sapiens_hsa006701.12597255
38RNA degradation_Homo sapiens_hsa030181.12488598
39Galactose metabolism_Homo sapiens_hsa000521.08508938
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.07397871
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05609676
42Cell cycle_Homo sapiens_hsa041101.04329847
43Phototransduction_Homo sapiens_hsa047441.01148103
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95361810
45Dilated cardiomyopathy_Homo sapiens_hsa054140.95252000
46Folate biosynthesis_Homo sapiens_hsa007900.94795946
47Sulfur relay system_Homo sapiens_hsa041220.91133088
48Basal transcription factors_Homo sapiens_hsa030220.85747226
49Steroid biosynthesis_Homo sapiens_hsa001000.83585332
50Viral myocarditis_Homo sapiens_hsa054160.80846593
51Fatty acid metabolism_Homo sapiens_hsa012120.80819546
52Fructose and mannose metabolism_Homo sapiens_hsa000510.77421534
53Epstein-Barr virus infection_Homo sapiens_hsa051690.75671405
54Glutathione metabolism_Homo sapiens_hsa004800.74304079
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.71594123
56Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.71251384
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.69724867
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68458811
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66628778
60Non-homologous end-joining_Homo sapiens_hsa034500.66501148
61Metabolic pathways_Homo sapiens_hsa011000.66042754
62Selenocompound metabolism_Homo sapiens_hsa004500.62845428
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.61401528
64Nitrogen metabolism_Homo sapiens_hsa009100.60335741
65Fatty acid elongation_Homo sapiens_hsa000620.58436332
66p53 signaling pathway_Homo sapiens_hsa041150.57728535
67Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.53966916
68Nicotine addiction_Homo sapiens_hsa050330.53866220
69Peroxisome_Homo sapiens_hsa041460.52720912
70Butanoate metabolism_Homo sapiens_hsa006500.51266710
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51015047
72Fanconi anemia pathway_Homo sapiens_hsa034600.50916258
73Arginine and proline metabolism_Homo sapiens_hsa003300.50732882
74Chemical carcinogenesis_Homo sapiens_hsa052040.49765156
75Collecting duct acid secretion_Homo sapiens_hsa049660.47257686
76beta-Alanine metabolism_Homo sapiens_hsa004100.46832614
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45290187
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43548120
79Vitamin B6 metabolism_Homo sapiens_hsa007500.42772256
80Oocyte meiosis_Homo sapiens_hsa041140.41961417
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41129893
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40743937
83Starch and sucrose metabolism_Homo sapiens_hsa005000.40169554
84N-Glycan biosynthesis_Homo sapiens_hsa005100.39902693
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38919615
86Regulation of autophagy_Homo sapiens_hsa041400.38869418
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38518119
88Legionellosis_Homo sapiens_hsa051340.38187570
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38130151
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.38060309
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37868743
92HIF-1 signaling pathway_Homo sapiens_hsa040660.37056359
93mRNA surveillance pathway_Homo sapiens_hsa030150.36589380
94Thyroid cancer_Homo sapiens_hsa052160.35848464
95Retinol metabolism_Homo sapiens_hsa008300.35717273
96Antigen processing and presentation_Homo sapiens_hsa046120.33410331
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32785530
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29917202
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29314379
100Taste transduction_Homo sapiens_hsa047420.28064319
101Olfactory transduction_Homo sapiens_hsa047400.27216795
102Primary immunodeficiency_Homo sapiens_hsa053400.26928834
103Insulin signaling pathway_Homo sapiens_hsa049100.26759269
104Fat digestion and absorption_Homo sapiens_hsa049750.26753643
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.24120410
106Vitamin digestion and absorption_Homo sapiens_hsa049770.23340965
107Linoleic acid metabolism_Homo sapiens_hsa005910.23322556
108Other glycan degradation_Homo sapiens_hsa005110.23256885
109Sulfur metabolism_Homo sapiens_hsa009200.23039239
110Herpes simplex infection_Homo sapiens_hsa051680.22645826
111Viral carcinogenesis_Homo sapiens_hsa052030.22522395
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.22269623
113Primary bile acid biosynthesis_Homo sapiens_hsa001200.21120473
114Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.20192439
115Tyrosine metabolism_Homo sapiens_hsa003500.19938296
116Glucagon signaling pathway_Homo sapiens_hsa049220.19620289
117Apoptosis_Homo sapiens_hsa042100.18035400
118Hedgehog signaling pathway_Homo sapiens_hsa043400.17961273
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.17087749
120Caffeine metabolism_Homo sapiens_hsa002320.16978151
121Tryptophan metabolism_Homo sapiens_hsa003800.16781106
122Arachidonic acid metabolism_Homo sapiens_hsa005900.15891862
123Phenylalanine metabolism_Homo sapiens_hsa003600.15478605
124HTLV-I infection_Homo sapiens_hsa051660.15477310
125AMPK signaling pathway_Homo sapiens_hsa041520.15456338
126Central carbon metabolism in cancer_Homo sapiens_hsa052300.15203070
127Insulin resistance_Homo sapiens_hsa049310.15186683
128Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.15164149
129Pentose and glucuronate interconversions_Homo sapiens_hsa000400.14982280
130Systemic lupus erythematosus_Homo sapiens_hsa053220.14646291
131Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.13717143
132Alcoholism_Homo sapiens_hsa050340.13646357
133Ether lipid metabolism_Homo sapiens_hsa005650.12949899

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