

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA deamination (GO:0045006) | 7.42502179 |
| 2 | viral transcription (GO:0019083) | 6.77969447 |
| 3 | ribosomal small subunit assembly (GO:0000028) | 6.75725042 |
| 4 | translational termination (GO:0006415) | 6.56804858 |
| 5 | ribosomal small subunit biogenesis (GO:0042274) | 6.26881078 |
| 6 | ribosomal large subunit biogenesis (GO:0042273) | 5.84459520 |
| 7 | translational elongation (GO:0006414) | 5.79954790 |
| 8 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 5.77499626 |
| 9 | maturation of SSU-rRNA (GO:0030490) | 5.71595611 |
| 10 | protein targeting to ER (GO:0045047) | 5.67355756 |
| 11 | cotranslational protein targeting to membrane (GO:0006613) | 5.63956242 |
| 12 | chaperone-mediated protein transport (GO:0072321) | 5.63393288 |
| 13 | protein localization to endoplasmic reticulum (GO:0070972) | 5.40246398 |
| 14 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 5.38653129 |
| 15 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 5.37926435 |
| 16 | translational initiation (GO:0006413) | 5.17580292 |
| 17 | viral life cycle (GO:0019058) | 5.08229178 |
| 18 | cellular protein complex disassembly (GO:0043624) | 5.05787546 |
| 19 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 4.91590436 |
| 20 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.90619107 |
| 21 | proteasome assembly (GO:0043248) | 4.76640424 |
| 22 | ribonucleoprotein complex biogenesis (GO:0022613) | 4.48085445 |
| 23 | ATP synthesis coupled proton transport (GO:0015986) | 4.47795903 |
| 24 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.47795903 |
| 25 | * translation (GO:0006412) | 4.47561421 |
| 26 | protein complex disassembly (GO:0043241) | 4.33415561 |
| 27 | regulation of mitochondrial translation (GO:0070129) | 4.16701204 |
| 28 | macromolecular complex disassembly (GO:0032984) | 4.13401566 |
| 29 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 4.09480200 |
| 30 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.89695067 |
| 31 | termination of RNA polymerase III transcription (GO:0006386) | 3.89695067 |
| 32 | cellular component biogenesis (GO:0044085) | 3.88176827 |
| 33 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.85291290 |
| 34 | pseudouridine synthesis (GO:0001522) | 3.84662541 |
| 35 | rRNA processing (GO:0006364) | 3.82914429 |
| 36 | rRNA modification (GO:0000154) | 3.78591778 |
| 37 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.76734918 |
| 38 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.76542810 |
| 39 | respiratory electron transport chain (GO:0022904) | 3.74457850 |
| 40 | cytochrome complex assembly (GO:0017004) | 3.73774247 |
| 41 | protein targeting to membrane (GO:0006612) | 3.69600242 |
| 42 | rRNA metabolic process (GO:0016072) | 3.69334390 |
| 43 | formation of translation preinitiation complex (GO:0001731) | 3.68008680 |
| 44 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.65491651 |
| 45 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.64913660 |
| 46 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.64913660 |
| 47 | electron transport chain (GO:0022900) | 3.64313886 |
| 48 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.63389682 |
| 49 | protein neddylation (GO:0045116) | 3.62362472 |
| 50 | oxidative phosphorylation (GO:0006119) | 3.61818231 |
| 51 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.61520506 |
| 52 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.61210715 |
| 53 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 3.61172126 |
| 54 | protein maturation by protein folding (GO:0022417) | 3.61094268 |
| 55 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.59624040 |
| 56 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.59275165 |
| 57 | ATP biosynthetic process (GO:0006754) | 3.58773056 |
| 58 | cullin deneddylation (GO:0010388) | 3.58286863 |
| 59 | mitochondrial transport (GO:0006839) | 3.56494338 |
| 60 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.55524569 |
| 61 | DNA strand elongation (GO:0022616) | 3.55489605 |
| 62 | positive regulation of ligase activity (GO:0051351) | 3.49670790 |
| 63 | spliceosomal snRNP assembly (GO:0000387) | 3.46622970 |
| 64 | DNA replication initiation (GO:0006270) | 3.44204432 |
| 65 | DNA replication checkpoint (GO:0000076) | 3.42804078 |
| 66 | folic acid metabolic process (GO:0046655) | 3.42742490 |
| 67 | mRNA catabolic process (GO:0006402) | 3.41234102 |
| 68 | protein deneddylation (GO:0000338) | 3.40926310 |
| 69 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.40207277 |
| 70 | nucleobase-containing small molecule interconversion (GO:0015949) | 3.40172516 |
| 71 | UTP biosynthetic process (GO:0006228) | 3.39961813 |
| 72 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 3.39313745 |
| 73 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.39139306 |
| 74 | amino acid salvage (GO:0043102) | 3.38110640 |
| 75 | L-methionine salvage (GO:0071267) | 3.38110640 |
| 76 | L-methionine biosynthetic process (GO:0071265) | 3.38110640 |
| 77 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 3.37339102 |
| 78 | respiratory chain complex IV assembly (GO:0008535) | 3.36315031 |
| 79 | ribosome biogenesis (GO:0042254) | 3.35475047 |
| 80 | deoxyribose phosphate biosynthetic process (GO:0046385) | 3.29763939 |
| 81 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 3.29763939 |
| 82 | purine nucleobase biosynthetic process (GO:0009113) | 3.28865295 |
| 83 | peptidyl-histidine modification (GO:0018202) | 3.25932072 |
| 84 | RNA catabolic process (GO:0006401) | 3.25195771 |
| 85 | nucleobase biosynthetic process (GO:0046112) | 3.24808246 |
| 86 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.24720512 |
| 87 | hydrogen ion transmembrane transport (GO:1902600) | 3.23777184 |
| 88 | pteridine-containing compound biosynthetic process (GO:0042559) | 3.22939132 |
| 89 | protein targeting to mitochondrion (GO:0006626) | 3.22851801 |
| 90 | telomere maintenance via recombination (GO:0000722) | 3.21161400 |
| 91 | protein complex biogenesis (GO:0070271) | 3.18180076 |
| 92 | nucleoside triphosphate biosynthetic process (GO:0009142) | 3.18055827 |
| 93 | establishment of protein localization to mitochondrion (GO:0072655) | 3.15733000 |
| 94 | regulation of ligase activity (GO:0051340) | 3.14860014 |
| 95 | iron-sulfur cluster assembly (GO:0016226) | 3.14246594 |
| 96 | metallo-sulfur cluster assembly (GO:0031163) | 3.14246594 |
| 97 | aerobic respiration (GO:0009060) | 3.13383136 |
| 98 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.12398716 |
| 99 | purine nucleoside monophosphate biosynthetic process (GO:0009127) | 3.12396926 |
| 100 | purine ribonucleoside monophosphate biosynthetic process (GO:0009168) | 3.12396926 |
| 101 | CTP metabolic process (GO:0046036) | 3.11559760 |
| 102 | CTP biosynthetic process (GO:0006241) | 3.11559760 |
| 103 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.10927131 |
| 104 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.10210073 |
| 105 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.08101417 |
| 106 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.07153004 |
| 107 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.07153004 |
| 108 | NADH dehydrogenase complex assembly (GO:0010257) | 3.07153004 |
| 109 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.06858851 |
| 110 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.06195540 |
| 111 | negative regulation of ligase activity (GO:0051352) | 3.06195540 |
| 112 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.05080056 |
| 113 | telomere maintenance via telomere lengthening (GO:0010833) | 3.04778941 |
| 114 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.02612694 |
| 115 | chromatin remodeling at centromere (GO:0031055) | 3.00710252 |
| 116 | spliceosomal complex assembly (GO:0000245) | 2.97401268 |
| 117 | ribosome assembly (GO:0042255) | 2.97168462 |
| 118 | glycine metabolic process (GO:0006544) | 2.94491078 |
| 119 | heme biosynthetic process (GO:0006783) | 2.92675205 |
| 120 | CENP-A containing nucleosome assembly (GO:0034080) | 2.90810687 |
| 121 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 2.90076358 |
| 122 | protein localization to mitochondrion (GO:0070585) | 2.89486718 |
| 123 | folic acid-containing compound biosynthetic process (GO:0009396) | 2.88342146 |
| 124 | mitotic recombination (GO:0006312) | 2.87084523 |
| 125 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.85090574 |
| 126 | quinone biosynthetic process (GO:1901663) | 2.85024098 |
| 127 | ubiquinone biosynthetic process (GO:0006744) | 2.85024098 |
| 128 | GTP biosynthetic process (GO:0006183) | 2.82356341 |
| 129 | rRNA methylation (GO:0031167) | 2.82286725 |
| 130 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 2.81783934 |
| 131 | transcription-coupled nucleotide-excision repair (GO:0006283) | 2.80112122 |
| 132 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.80017544 |
| 133 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.80017544 |
| 134 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.80017544 |
| 135 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.79866663 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 4.72809631 |
| 2 | * MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.46060613 |
| 3 | * EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 4.20329863 |
| 4 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.74293615 |
| 5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.56627950 |
| 6 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.39574152 |
| 7 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.32284237 |
| 8 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.20854921 |
| 9 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.14030996 |
| 10 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.12799333 |
| 11 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.96853590 |
| 12 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.95550736 |
| 13 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.87907226 |
| 14 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.76471463 |
| 15 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.64765535 |
| 16 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.44410309 |
| 17 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.33833581 |
| 18 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.30150147 |
| 19 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.29697532 |
| 20 | * DCP1A_22483619_ChIP-Seq_HELA_Human | 2.28926083 |
| 21 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.27306767 |
| 22 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.27193190 |
| 23 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.20639443 |
| 24 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.14304781 |
| 25 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.07522394 |
| 26 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.05647485 |
| 27 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.04278973 |
| 28 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.98299470 |
| 29 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.97867833 |
| 30 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.96932818 |
| 31 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.93741934 |
| 32 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.89874670 |
| 33 | * TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.86433766 |
| 34 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.84446195 |
| 35 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.82863834 |
| 36 | * TTF2_22483619_ChIP-Seq_HELA_Human | 1.82485868 |
| 37 | * CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.68969762 |
| 38 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.66971132 |
| 39 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.66469213 |
| 40 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.60924580 |
| 41 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.57323369 |
| 42 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.57292042 |
| 43 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 1.57250880 |
| 44 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.54958358 |
| 45 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.53821393 |
| 46 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.52883617 |
| 47 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.48238378 |
| 48 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.46880388 |
| 49 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.46247941 |
| 50 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.44752469 |
| 51 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.44016778 |
| 52 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.41220296 |
| 53 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.37576078 |
| 54 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.36182777 |
| 55 | * PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.35456782 |
| 56 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.35378666 |
| 57 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.33529469 |
| 58 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.32545411 |
| 59 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.31288248 |
| 60 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.30460899 |
| 61 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.28715561 |
| 62 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.25549587 |
| 63 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.24889622 |
| 64 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.24341960 |
| 65 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.24217287 |
| 66 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.24175617 |
| 67 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.22835852 |
| 68 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.22532896 |
| 69 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.20203201 |
| 70 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.19740696 |
| 71 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.19464909 |
| 72 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.17116359 |
| 73 | * DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.12445675 |
| 74 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.12047039 |
| 75 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.10826503 |
| 76 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.10823108 |
| 77 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.10667208 |
| 78 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.10567655 |
| 79 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.06613297 |
| 80 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.05258043 |
| 81 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.04421870 |
| 82 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 1.03267227 |
| 83 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.02688974 |
| 84 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.01872686 |
| 85 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.99251362 |
| 86 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.99021489 |
| 87 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.97577126 |
| 88 | VDR_21846776_ChIP-Seq_THP-1_Human | 0.97244009 |
| 89 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.96921153 |
| 90 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.96871378 |
| 91 | * OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.95797257 |
| 92 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.95750109 |
| 93 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.93795263 |
| 94 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.93788559 |
| 95 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.92971484 |
| 96 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.92871201 |
| 97 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.92420730 |
| 98 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.92171284 |
| 99 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.91099150 |
| 100 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.90813257 |
| 101 | * SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.90789068 |
| 102 | * CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.88684686 |
| 103 | MYC_22102868_ChIP-Seq_BL_Human | 0.88341032 |
| 104 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.87979742 |
| 105 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.87919989 |
| 106 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.87424927 |
| 107 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 0.87293109 |
| 108 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 0.86127683 |
| 109 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.85671588 |
| 110 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.84935500 |
| 111 | * ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 0.82524092 |
| 112 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.78601562 |
| 113 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.76295078 |
| 114 | * TRIM28_19339689_ChIP-ChIP_MESCs_Mouse | 0.75635943 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 4.83946401 |
| 2 | MP0003806_abnormal_nucleotide_metabolis | 4.33759217 |
| 3 | MP0009379_abnormal_foot_pigmentation | 4.25474656 |
| 4 | MP0004957_abnormal_blastocyst_morpholog | 3.77960989 |
| 5 | MP0003111_abnormal_nucleus_morphology | 3.04204199 |
| 6 | MP0000372_irregular_coat_pigmentation | 2.82512677 |
| 7 | MP0003186_abnormal_redox_activity | 2.74524821 |
| 8 | MP0006036_abnormal_mitochondrial_physio | 2.60096276 |
| 9 | MP0010094_abnormal_chromosome_stability | 2.58579210 |
| 10 | MP0003077_abnormal_cell_cycle | 2.53590091 |
| 11 | MP0005360_urolithiasis | 2.29247472 |
| 12 | MP0005085_abnormal_gallbladder_physiolo | 2.29082786 |
| 13 | MP0002139_abnormal_hepatobiliary_system | 2.26755964 |
| 14 | MP0009840_abnormal_foam_cell | 2.24826966 |
| 15 | MP0000490_abnormal_crypts_of | 2.21609344 |
| 16 | MP0003718_maternal_effect | 2.21397040 |
| 17 | MP0002163_abnormal_gland_morphology | 2.11972005 |
| 18 | MP0008932_abnormal_embryonic_tissue | 2.11743144 |
| 19 | MP0005083_abnormal_biliary_tract | 2.06162014 |
| 20 | MP0008058_abnormal_DNA_repair | 2.03718620 |
| 21 | MP0002132_abnormal_respiratory_system | 2.00311819 |
| 22 | MP0002837_dystrophic_cardiac_calcinosis | 1.91217642 |
| 23 | MP0005365_abnormal_bile_salt | 1.84831367 |
| 24 | MP0003656_abnormal_erythrocyte_physiolo | 1.82194365 |
| 25 | MP0001764_abnormal_homeostasis | 1.76425361 |
| 26 | MP0006035_abnormal_mitochondrial_morpho | 1.70403368 |
| 27 | MP0002396_abnormal_hematopoietic_system | 1.69323172 |
| 28 | MP0001529_abnormal_vocalization | 1.69232745 |
| 29 | MP0004145_abnormal_muscle_electrophysio | 1.62977715 |
| 30 | MP0003011_delayed_dark_adaptation | 1.61537162 |
| 31 | MP0004147_increased_porphyrin_level | 1.61062295 |
| 32 | MP0009333_abnormal_splenocyte_physiolog | 1.60492321 |
| 33 | MP0003941_abnormal_skin_development | 1.60473461 |
| 34 | MP0003646_muscle_fatigue | 1.60021403 |
| 35 | MP0005332_abnormal_amino_acid | 1.54143578 |
| 36 | MP0002938_white_spotting | 1.54066448 |
| 37 | MP0003315_abnormal_perineum_morphology | 1.41685141 |
| 38 | MP0003123_paternal_imprinting | 1.40760706 |
| 39 | MP0003786_premature_aging | 1.39575611 |
| 40 | MP0002736_abnormal_nociception_after | 1.37960463 |
| 41 | MP0001666_abnormal_nutrient_absorption | 1.37855200 |
| 42 | MP0008007_abnormal_cellular_replicative | 1.36013893 |
| 43 | MP0005075_abnormal_melanosome_morpholog | 1.35757572 |
| 44 | MP0008057_abnormal_DNA_replication | 1.31896037 |
| 45 | MP0001542_abnormal_bone_strength | 1.31788765 |
| 46 | MP0001661_extended_life_span | 1.29122116 |
| 47 | MP0002160_abnormal_reproductive_system | 1.27036216 |
| 48 | MP0002234_abnormal_pharynx_morphology | 1.23868020 |
| 49 | MP0008789_abnormal_olfactory_epithelium | 1.22062703 |
| 50 | MP0001905_abnormal_dopamine_level | 1.20558553 |
| 51 | MP0001730_embryonic_growth_arrest | 1.19488107 |
| 52 | MP0005451_abnormal_body_composition | 1.18841527 |
| 53 | MP0003567_abnormal_fetal_cardiomyocyte | 1.17740330 |
| 54 | MP0002332_abnormal_exercise_endurance | 1.17445467 |
| 55 | MP0009643_abnormal_urine_homeostasis | 1.16858248 |
| 56 | MP0005670_abnormal_white_adipose | 1.15105861 |
| 57 | MP0005319_abnormal_enzyme/_coenzyme | 1.14875458 |
| 58 | MP0005636_abnormal_mineral_homeostasis | 1.13087203 |
| 59 | MP0005408_hypopigmentation | 1.12849547 |
| 60 | MP0005379_endocrine/exocrine_gland_phen | 1.10938910 |
| 61 | MP0005220_abnormal_exocrine_pancreas | 1.10197489 |
| 62 | MP0004233_abnormal_muscle_weight | 1.10071500 |
| 63 | MP0003763_abnormal_thymus_physiology | 1.09100361 |
| 64 | MP0002019_abnormal_tumor_incidence | 1.06790260 |
| 65 | MP0003221_abnormal_cardiomyocyte_apopto | 1.05846070 |
| 66 | MP0000358_abnormal_cell_content/ | 1.05488187 |
| 67 | MP0000678_abnormal_parathyroid_gland | 1.04711363 |
| 68 | MP0000313_abnormal_cell_death | 1.03904218 |
| 69 | MP0004019_abnormal_vitamin_homeostasis | 1.02056923 |
| 70 | MP0008875_abnormal_xenobiotic_pharmacok | 1.01462126 |
| 71 | MP0000049_abnormal_middle_ear | 1.01218423 |
| 72 | MP0000350_abnormal_cell_proliferation | 1.01005452 |
| 73 | MP0005389_reproductive_system_phenotype | 1.00956785 |
| 74 | MP0005330_cardiomyopathy | 1.00814763 |
| 75 | MP0003137_abnormal_impulse_conducting | 0.99045960 |
| 76 | MP0001881_abnormal_mammary_gland | 0.98768838 |
| 77 | MP0003950_abnormal_plasma_membrane | 0.98225086 |
| 78 | MP0000750_abnormal_muscle_regeneration | 0.96093918 |
| 79 | MP0009697_abnormal_copulation | 0.95020572 |
| 80 | MP0002080_prenatal_lethality | 0.92501170 |
| 81 | MP0001853_heart_inflammation | 0.92074848 |
| 82 | MP0000613_abnormal_salivary_gland | 0.91725528 |
| 83 | MP0000343_altered_response_to | 0.90478330 |
| 84 | MP0008995_early_reproductive_senescence | 0.90382763 |
| 85 | MP0001545_abnormal_hematopoietic_system | 0.90125112 |
| 86 | MP0005397_hematopoietic_system_phenotyp | 0.90125112 |
| 87 | MP0005084_abnormal_gallbladder_morpholo | 0.90110165 |
| 88 | MP0001697_abnormal_embryo_size | 0.89827974 |
| 89 | MP0002210_abnormal_sex_determination | 0.89790184 |
| 90 | MP0005266_abnormal_metabolism | 0.89131430 |
| 91 | MP0002722_abnormal_immune_system | 0.88585842 |
| 92 | MP0000689_abnormal_spleen_morphology | 0.84267466 |
| 93 | MP0002269_muscular_atrophy | 0.83115211 |
| 94 | MP0005410_abnormal_fertilization | 0.82607166 |
| 95 | MP0001919_abnormal_reproductive_system | 0.81941390 |
| 96 | MP0000858_altered_metastatic_potential | 0.81402950 |
| 97 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.80906820 |
| 98 | MP0001663_abnormal_digestive_system | 0.80740854 |
| 99 | MP0001873_stomach_inflammation | 0.80541533 |
| 100 | MP0009046_muscle_twitch | 0.80178545 |
| 101 | MP0008469_abnormal_protein_level | 0.79898873 |
| 102 | MP0002102_abnormal_ear_morphology | 0.79662955 |
| 103 | MP0003724_increased_susceptibility_to | 0.79089948 |
| 104 | MP0000759_abnormal_skeletal_muscle | 0.78335220 |
| 105 | MP0002138_abnormal_hepatobiliary_system | 0.78049294 |
| 106 | MP0010155_abnormal_intestine_physiology | 0.77918723 |
| 107 | MP0000609_abnormal_liver_physiology | 0.77306728 |
| 108 | MP0002638_abnormal_pupillary_reflex | 0.77121664 |
| 109 | MP0000751_myopathy | 0.77106297 |
| 110 | MP0000462_abnormal_digestive_system | 0.76893178 |
| 111 | MP0004215_abnormal_myocardial_fiber | 0.76578803 |
| 112 | MP0005174_abnormal_tail_pigmentation | 0.76225740 |
| 113 | MP0000477_abnormal_intestine_morphology | 0.75785430 |
| 114 | MP0001968_abnormal_touch/_nociception | 0.74068870 |
| 115 | MP0005381_digestive/alimentary_phenotyp | 0.73445570 |
| 116 | MP0009785_altered_susceptibility_to | 0.73338398 |
| 117 | MP0000598_abnormal_liver_morphology | 0.73097325 |
| 118 | MP0000747_muscle_weakness | 0.72703396 |
| 119 | MP0004142_abnormal_muscle_tone | 0.72297924 |
| 120 | MP0002429_abnormal_blood_cell | 0.72257874 |
| 121 | MP0010030_abnormal_orbit_morphology | 0.71857994 |
| 122 | MP0005380_embryogenesis_phenotype | 0.71837435 |
| 123 | MP0001672_abnormal_embryogenesis/_devel | 0.71837435 |
| 124 | MP0008872_abnormal_physiological_respon | 0.71781540 |
| 125 | MP0000703_abnormal_thymus_morphology | 0.69891761 |
| 126 | MP0003866_abnormal_defecation | 0.69509311 |
| 127 | MP0002398_abnormal_bone_marrow | 0.69395147 |
| 128 | MP0005376_homeostasis/metabolism_phenot | 0.69348846 |
| 129 | MP0002277_abnormal_respiratory_mucosa | 0.67787594 |
| 130 | MP0006292_abnormal_olfactory_placode | 0.67525182 |
| 131 | MP0001293_anophthalmia | 0.66919906 |
| 132 | MP0005025_abnormal_response_to | 0.66549449 |
| 133 | MP0001756_abnormal_urination | 0.66532507 |
| 134 | MP0004381_abnormal_hair_follicle | 0.66164305 |
| 135 | MP0002106_abnormal_muscle_physiology | 0.65786759 |
| 136 | MP0006072_abnormal_retinal_apoptosis | 0.65693425 |
| 137 | MP0008873_increased_physiological_sensi | 0.64547714 |
| 138 | MP0001929_abnormal_gametogenesis | 0.64177616 |
| 139 | MP0003195_calcinosis | 0.63273283 |
| 140 | MP0005165_increased_susceptibility_to | 0.63245547 |
| 141 | MP0008004_abnormal_stomach_pH | 0.62726021 |
| 142 | MP0003984_embryonic_growth_retardation | 0.62525319 |
| 143 | MP0000749_muscle_degeneration | 0.62421724 |
| 144 | MP0003191_abnormal_cellular_cholesterol | 0.61878050 |
| 145 | MP0000653_abnormal_sex_gland | 0.61272389 |
| 146 | MP0006054_spinal_hemorrhage | 0.60960650 |
| 147 | MP0001145_abnormal_male_reproductive | 0.60603986 |
| 148 | MP0001727_abnormal_embryo_implantation | 0.59936030 |
| 149 | MP0005369_muscle_phenotype | 0.57820817 |
| 150 | MP0005501_abnormal_skin_physiology | 0.57414775 |
| 151 | MP0009250_abnormal_appendicular_skeleto | 0.57171475 |
| 152 | MP0009053_abnormal_anal_canal | 0.55796692 |
| 153 | MP0004036_abnormal_muscle_relaxation | 0.55231096 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of cells of the erythroid lineage (HP:0012130) | 5.69573638 |
| 2 | Abnormal number of erythroid precursors (HP:0012131) | 5.42592119 |
| 3 | Reticulocytopenia (HP:0001896) | 5.01213401 |
| 4 | Hepatocellular necrosis (HP:0001404) | 4.64432365 |
| 5 | Hepatic necrosis (HP:0002605) | 4.57479880 |
| 6 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 4.54688960 |
| 7 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 4.54688960 |
| 8 | Mitochondrial inheritance (HP:0001427) | 4.44680406 |
| 9 | Increased hepatocellular lipid droplets (HP:0006565) | 4.35675766 |
| 10 | Macrocytic anemia (HP:0001972) | 4.34133001 |
| 11 | Lipid accumulation in hepatocytes (HP:0006561) | 4.26423653 |
| 12 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 4.23538832 |
| 13 | Increased intramyocellular lipid droplets (HP:0012240) | 4.07242554 |
| 14 | Increased CSF lactate (HP:0002490) | 4.06911786 |
| 15 | Acute necrotizing encephalopathy (HP:0006965) | 4.05605281 |
| 16 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.92817972 |
| 17 | Increased serum lactate (HP:0002151) | 3.84804840 |
| 18 | Increased muscle lipid content (HP:0009058) | 3.84781114 |
| 19 | Acute encephalopathy (HP:0006846) | 3.77272116 |
| 20 | Pallor (HP:0000980) | 3.77094083 |
| 21 | Oral leukoplakia (HP:0002745) | 3.59078977 |
| 22 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.58700827 |
| 23 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 3.55879071 |
| 24 | 3-Methylglutaconic aciduria (HP:0003535) | 3.38771416 |
| 25 | Lactic acidosis (HP:0003128) | 3.35929141 |
| 26 | Exertional dyspnea (HP:0002875) | 3.32931130 |
| 27 | Renal Fanconi syndrome (HP:0001994) | 3.30588899 |
| 28 | Cerebral edema (HP:0002181) | 3.21427208 |
| 29 | Abnormal hemoglobin (HP:0011902) | 3.16214717 |
| 30 | Breast hypoplasia (HP:0003187) | 3.13429273 |
| 31 | Progressive macrocephaly (HP:0004481) | 3.09061188 |
| 32 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.95614880 |
| 33 | Abnormality of alanine metabolism (HP:0010916) | 2.95614880 |
| 34 | Hyperalaninemia (HP:0003348) | 2.95614880 |
| 35 | Respiratory failure (HP:0002878) | 2.93257741 |
| 36 | Exercise intolerance (HP:0003546) | 2.87196320 |
| 37 | Multiple enchondromatosis (HP:0005701) | 2.86135291 |
| 38 | Leukodystrophy (HP:0002415) | 2.83077838 |
| 39 | Microvesicular hepatic steatosis (HP:0001414) | 2.83025549 |
| 40 | Cerebral hypomyelination (HP:0006808) | 2.78861060 |
| 41 | Dicarboxylic aciduria (HP:0003215) | 2.78289016 |
| 42 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.78289016 |
| 43 | Aplastic anemia (HP:0001915) | 2.77360570 |
| 44 | Lethargy (HP:0001254) | 2.75276554 |
| 45 | Hyperglycinemia (HP:0002154) | 2.74772227 |
| 46 | Progressive muscle weakness (HP:0003323) | 2.72745115 |
| 47 | CNS demyelination (HP:0007305) | 2.70435927 |
| 48 | Rough bone trabeculation (HP:0100670) | 2.70388997 |
| 49 | Optic disc pallor (HP:0000543) | 2.70273332 |
| 50 | Birth length less than 3rd percentile (HP:0003561) | 2.68597181 |
| 51 | Respiratory difficulties (HP:0002880) | 2.66325279 |
| 52 | Type I transferrin isoform profile (HP:0003642) | 2.45041524 |
| 53 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 2.43537543 |
| 54 | Microretrognathia (HP:0000308) | 2.43436712 |
| 55 | Abnormality of glycolysis (HP:0004366) | 2.42133174 |
| 56 | Increased serum pyruvate (HP:0003542) | 2.42133174 |
| 57 | Glycosuria (HP:0003076) | 2.41773851 |
| 58 | Abnormality of urine glucose concentration (HP:0011016) | 2.41773851 |
| 59 | Hyperammonemia (HP:0001987) | 2.40288925 |
| 60 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 2.38866480 |
| 61 | Abnormality of serum amino acid levels (HP:0003112) | 2.38349749 |
| 62 | Nausea (HP:0002018) | 2.37761208 |
| 63 | Trismus (HP:0000211) | 2.36492106 |
| 64 | Hyperglycinuria (HP:0003108) | 2.34788295 |
| 65 | Reduced antithrombin III activity (HP:0001976) | 2.33142879 |
| 66 | Emotional lability (HP:0000712) | 2.28242057 |
| 67 | Pancytopenia (HP:0001876) | 2.27402933 |
| 68 | Ragged-red muscle fibers (HP:0003200) | 2.24894552 |
| 69 | Hyperphosphaturia (HP:0003109) | 2.22918250 |
| 70 | Abnormality of glycine metabolism (HP:0010895) | 2.20343417 |
| 71 | Abnormality of serine family amino acid metabolism (HP:0010894) | 2.20343417 |
| 72 | Degeneration of anterior horn cells (HP:0002398) | 2.20023848 |
| 73 | Abnormality of the anterior horn cell (HP:0006802) | 2.20023848 |
| 74 | X-linked dominant inheritance (HP:0001423) | 2.18978211 |
| 75 | Abnormality of reticulocytes (HP:0004312) | 2.18887645 |
| 76 | Nemaline bodies (HP:0003798) | 2.18423593 |
| 77 | Secondary amenorrhea (HP:0000869) | 2.18079544 |
| 78 | Opisthotonus (HP:0002179) | 2.05966072 |
| 79 | Muscle fiber inclusion bodies (HP:0100299) | 2.04407029 |
| 80 | Abnormality of renal resorption (HP:0011038) | 2.04175959 |
| 81 | Premature ovarian failure (HP:0008209) | 2.03440811 |
| 82 | Ileus (HP:0002595) | 2.02953309 |
| 83 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 1.99594926 |
| 84 | Generalized aminoaciduria (HP:0002909) | 1.98525588 |
| 85 | Abnormality of fatty-acid metabolism (HP:0004359) | 1.96197931 |
| 86 | Colon cancer (HP:0003003) | 1.95036321 |
| 87 | Abnormal trabecular bone morphology (HP:0100671) | 1.92458527 |
| 88 | Rhabdomyolysis (HP:0003201) | 1.91939374 |
| 89 | Sparse eyelashes (HP:0000653) | 1.91479292 |
| 90 | Delayed CNS myelination (HP:0002188) | 1.91257947 |
| 91 | Carpal bone hypoplasia (HP:0001498) | 1.91216323 |
| 92 | Blindness (HP:0000618) | 1.90176219 |
| 93 | Redundant skin (HP:0001582) | 1.89956348 |
| 94 | Absent thumb (HP:0009777) | 1.87603675 |
| 95 | Progressive microcephaly (HP:0000253) | 1.87546327 |
| 96 | Triphalangeal thumb (HP:0001199) | 1.87495220 |
| 97 | Gout (HP:0001997) | 1.87205482 |
| 98 | Abnormality of pyrimidine metabolism (HP:0004353) | 1.86822459 |
| 99 | Testicular atrophy (HP:0000029) | 1.85512040 |
| 100 | Abnormal protein glycosylation (HP:0012346) | 1.85187392 |
| 101 | Abnormal glycosylation (HP:0012345) | 1.85187392 |
| 102 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.85187392 |
| 103 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.85187392 |
| 104 | Abnormality of the preputium (HP:0100587) | 1.85156974 |
| 105 | Increased serum ferritin (HP:0003281) | 1.85038440 |
| 106 | Neoplasm of head and neck (HP:0012288) | 1.84042402 |
| 107 | Esophageal neoplasm (HP:0100751) | 1.84042402 |
| 108 | Thrombocytosis (HP:0001894) | 1.83937346 |
| 109 | Cleft eyelid (HP:0000625) | 1.83449625 |
| 110 | Abnormal pupillary function (HP:0007686) | 1.81718246 |
| 111 | Abnormality of placental membranes (HP:0011409) | 1.80984410 |
| 112 | Amniotic constriction ring (HP:0009775) | 1.80984410 |
| 113 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 1.79103986 |
| 114 | Vomiting (HP:0002013) | 1.78329909 |
| 115 | Hypobetalipoproteinemia (HP:0003563) | 1.76588153 |
| 116 | Premature graying of hair (HP:0002216) | 1.76545647 |
| 117 | Methylmalonic aciduria (HP:0012120) | 1.76340415 |
| 118 | Gliosis (HP:0002171) | 1.72400458 |
| 119 | Hypokinesia (HP:0002375) | 1.70219496 |
| 120 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.70093296 |
| 121 | Methylmalonic acidemia (HP:0002912) | 1.69184989 |
| 122 | Myopathic facies (HP:0002058) | 1.68729248 |
| 123 | Abnormality of methionine metabolism (HP:0010901) | 1.67956252 |
| 124 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 1.64393414 |
| 125 | Exercise-induced muscle cramps (HP:0003710) | 1.63337590 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NME2 | 4.86391354 |
| 2 | BUB1 | 4.76845975 |
| 3 | VRK2 | 4.64505829 |
| 4 | TLK1 | 4.29239502 |
| 5 | STK16 | 3.71100387 |
| 6 | EIF2AK1 | 3.46437299 |
| 7 | WEE1 | 3.19737396 |
| 8 | BCKDK | 3.14574336 |
| 9 | NME1 | 2.87007273 |
| 10 | TESK2 | 2.63258041 |
| 11 | PDK2 | 2.32265503 |
| 12 | LIMK1 | 2.14463210 |
| 13 | MAP3K11 | 2.06155991 |
| 14 | KDR | 2.02943622 |
| 15 | VRK1 | 1.98394351 |
| 16 | MAP3K12 | 1.96530586 |
| 17 | SRPK1 | 1.81614099 |
| 18 | DYRK3 | 1.79140462 |
| 19 | EIF2AK3 | 1.67498602 |
| 20 | PIM2 | 1.67173932 |
| 21 | NEK2 | 1.57516689 |
| 22 | IRAK3 | 1.54054943 |
| 23 | PLK4 | 1.49325260 |
| 24 | PLK1 | 1.40946111 |
| 25 | PBK | 1.37914500 |
| 26 | EPHA2 | 1.36683497 |
| 27 | TTK | 1.36227003 |
| 28 | AURKB | 1.33330108 |
| 29 | TAOK3 | 1.30557467 |
| 30 | AURKA | 1.29662918 |
| 31 | RPS6KA4 | 1.29513475 |
| 32 | CDC7 | 1.28698712 |
| 33 | ZAK | 1.27919798 |
| 34 | RPS6KB2 | 1.24988805 |
| 35 | ACVR1B | 1.24168822 |
| 36 | CDK7 | 1.24076954 |
| 37 | NEK1 | 1.23471157 |
| 38 | CSNK1G3 | 1.22842622 |
| 39 | CDK19 | 1.15391757 |
| 40 | NUAK1 | 1.10264009 |
| 41 | MAP4K1 | 1.09010847 |
| 42 | PLK3 | 1.07257276 |
| 43 | DAPK1 | 1.02281751 |
| 44 | ILK | 1.02172022 |
| 45 | MAP2K2 | 1.00606541 |
| 46 | MAP4K2 | 0.99108406 |
| 47 | TRIM28 | 0.96158011 |
| 48 | BRAF | 0.96064227 |
| 49 | BRSK2 | 0.95458678 |
| 50 | MST1R | 0.95031258 |
| 51 | PASK | 0.94980714 |
| 52 | CSNK1G1 | 0.92156619 |
| 53 | PHKG2 | 0.91324453 |
| 54 | PHKG1 | 0.91324453 |
| 55 | LMTK2 | 0.91256677 |
| 56 | ABL2 | 0.90186913 |
| 57 | BLK | 0.89354442 |
| 58 | MAP3K8 | 0.89136887 |
| 59 | MAPKAPK3 | 0.87869611 |
| 60 | CDK4 | 0.87278484 |
| 61 | FLT3 | 0.86667938 |
| 62 | CSNK1G2 | 0.83361238 |
| 63 | CSNK1A1L | 0.81714327 |
| 64 | DYRK2 | 0.80061573 |
| 65 | SCYL2 | 0.77873819 |
| 66 | MAP2K6 | 0.75862120 |
| 67 | PAK4 | 0.75595007 |
| 68 | CHEK2 | 0.72473801 |
| 69 | DAPK3 | 0.71223554 |
| 70 | ZAP70 | 0.71104693 |
| 71 | MAP2K3 | 0.68751812 |
| 72 | STK38L | 0.68665076 |
| 73 | CSNK2A1 | 0.68625512 |
| 74 | CDK8 | 0.68503399 |
| 75 | CSNK2A2 | 0.67751277 |
| 76 | MYLK | 0.66842665 |
| 77 | GRK5 | 0.62252162 |
| 78 | IRAK4 | 0.61068836 |
| 79 | CCNB1 | 0.61059915 |
| 80 | PAK1 | 0.60967191 |
| 81 | TAOK2 | 0.60124951 |
| 82 | EIF2AK2 | 0.59416138 |
| 83 | TAF1 | 0.58481582 |
| 84 | STK4 | 0.58075835 |
| 85 | CAMK2G | 0.57925004 |
| 86 | RPS6KA5 | 0.57213603 |
| 87 | ATR | 0.56698297 |
| 88 | PINK1 | 0.55554905 |
| 89 | PRKCI | 0.55452128 |
| 90 | LRRK2 | 0.54036569 |
| 91 | BRSK1 | 0.53826798 |
| 92 | TESK1 | 0.53787587 |
| 93 | ERN1 | 0.51312807 |
| 94 | MST4 | 0.49092256 |
| 95 | ADRBK2 | 0.48910925 |
| 96 | PIM1 | 0.47611358 |
| 97 | MAPK11 | 0.47087505 |
| 98 | MAP3K3 | 0.46668095 |
| 99 | NEK9 | 0.45995793 |
| 100 | TEC | 0.45405568 |
| 101 | GRK7 | 0.45177346 |
| 102 | MKNK2 | 0.45174600 |
| 103 | TSSK6 | 0.44412782 |
| 104 | MAP2K7 | 0.43672732 |
| 105 | MOS | 0.42127589 |
| 106 | GRK1 | 0.40321006 |
| 107 | PIK3CG | 0.39529698 |
| 108 | GRK6 | 0.38508850 |
| 109 | CHEK1 | 0.37504269 |
| 110 | TBK1 | 0.36476541 |
| 111 | PRKG2 | 0.35881583 |
| 112 | MAP3K10 | 0.35807267 |
| 113 | CAMK2D | 0.35580005 |
| 114 | IKBKB | 0.34851151 |
| 115 | EPHB2 | 0.34775178 |
| 116 | PKN2 | 0.33545295 |
| 117 | MUSK | 0.32401559 |
| 118 | MAPKAPK5 | 0.31953034 |
| 119 | MKNK1 | 0.30789486 |
| 120 | PKN1 | 0.30246872 |
| 121 | WNK3 | 0.29804175 |
| 122 | IRAK2 | 0.29001461 |
| 123 | TYK2 | 0.28914858 |
| 124 | ARAF | 0.27399241 |
| 125 | OBSCN | 0.26832783 |
| 126 | IRAK1 | 0.26499638 |
| 127 | MAPK4 | 0.26055543 |
| 128 | CSNK1A1 | 0.25429442 |
| 129 | AKT2 | 0.25163291 |
| 130 | BTK | 0.25017635 |
| 131 | ERBB4 | 0.23402367 |
| 132 | CDK11A | 0.22285672 |
| 133 | RAF1 | 0.21148621 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome_Homo sapiens_hsa03010 | 5.51899608 |
| 2 | DNA replication_Homo sapiens_hsa03030 | 3.57888009 |
| 3 | Proteasome_Homo sapiens_hsa03050 | 3.35694088 |
| 4 | RNA polymerase_Homo sapiens_hsa03020 | 3.18827705 |
| 5 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.85579156 |
| 6 | Mismatch repair_Homo sapiens_hsa03430 | 2.77032011 |
| 7 | Parkinsons disease_Homo sapiens_hsa05012 | 2.70837168 |
| 8 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.53752751 |
| 9 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.39648783 |
| 10 | Homologous recombination_Homo sapiens_hsa03440 | 2.25345253 |
| 11 | Folate biosynthesis_Homo sapiens_hsa00790 | 2.19634954 |
| 12 | Spliceosome_Homo sapiens_hsa03040 | 2.12370154 |
| 13 | Huntingtons disease_Homo sapiens_hsa05016 | 2.00795767 |
| 14 | Base excision repair_Homo sapiens_hsa03410 | 1.99852193 |
| 15 | Sulfur relay system_Homo sapiens_hsa04122 | 1.93357163 |
| 16 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.91592776 |
| 17 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.83525574 |
| 18 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.83199675 |
| 19 | Protein export_Homo sapiens_hsa03060 | 1.78926441 |
| 20 | RNA transport_Homo sapiens_hsa03013 | 1.68733764 |
| 21 | Alzheimers disease_Homo sapiens_hsa05010 | 1.65210837 |
| 22 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.55986008 |
| 23 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.49551019 |
| 24 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.45152754 |
| 25 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.42696554 |
| 26 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.41667489 |
| 27 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.39681792 |
| 28 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.39092765 |
| 29 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.33365193 |
| 30 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.29912820 |
| 31 | Purine metabolism_Homo sapiens_hsa00230 | 1.22922030 |
| 32 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.20398810 |
| 33 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.15129709 |
| 34 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.13425086 |
| 35 | Carbon metabolism_Homo sapiens_hsa01200 | 1.13103498 |
| 36 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.11447876 |
| 37 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.10673702 |
| 38 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.09888819 |
| 39 | Cell cycle_Homo sapiens_hsa04110 | 1.09144637 |
| 40 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.09040625 |
| 41 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.08339517 |
| 42 | Basal transcription factors_Homo sapiens_hsa03022 | 1.07117655 |
| 43 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.05210232 |
| 44 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.03231869 |
| 45 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.03126293 |
| 46 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.03015505 |
| 47 | RNA degradation_Homo sapiens_hsa03018 | 0.99532603 |
| 48 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.93847855 |
| 49 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.92506955 |
| 50 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.90237945 |
| 51 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.84866894 |
| 52 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.84583156 |
| 53 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.84497923 |
| 54 | Metabolic pathways_Homo sapiens_hsa01100 | 0.83479460 |
| 55 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.77851687 |
| 56 | Peroxisome_Homo sapiens_hsa04146 | 0.77702955 |
| 57 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.76874107 |
| 58 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.75558807 |
| 59 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.72028712 |
| 60 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.65242438 |
| 61 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.63685554 |
| 62 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.63340147 |
| 63 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.61197057 |
| 64 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.58001571 |
| 65 | Galactose metabolism_Homo sapiens_hsa00052 | 0.56374847 |
| 66 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.56161600 |
| 67 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.55533639 |
| 68 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.55263443 |
| 69 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.55209531 |
| 70 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.54643949 |
| 71 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.54162061 |
| 72 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.51946403 |
| 73 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.51772714 |
| 74 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.49647197 |
| 75 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.49494290 |
| 76 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.48754190 |
| 77 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.48447287 |
| 78 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.48089207 |
| 79 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.47458111 |
| 80 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.46222984 |
| 81 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.45978443 |
| 82 | Retinol metabolism_Homo sapiens_hsa00830 | 0.44593475 |
| 83 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.44213215 |
| 84 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.43834227 |
| 85 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.41004814 |
| 86 | Other glycan degradation_Homo sapiens_hsa00511 | 0.37634264 |
| 87 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.35177878 |
| 88 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.33877119 |
| 89 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.33272299 |
| 90 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.32203094 |
| 91 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.31935599 |
| 92 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.30658085 |
| 93 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.30405511 |
| 94 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.30109176 |
| 95 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.29259450 |
| 96 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.26364751 |
| 97 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.25144882 |
| 98 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.24574828 |
| 99 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.24325851 |
| 100 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.22827232 |
| 101 | Histidine metabolism_Homo sapiens_hsa00340 | 0.22783946 |
| 102 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.22280552 |
| 103 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.21709152 |
| 104 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.20087570 |
| 105 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.19578931 |
| 106 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.19047965 |
| 107 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.18336939 |
| 108 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.17727451 |
| 109 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.17623471 |
| 110 | Thyroid cancer_Homo sapiens_hsa05216 | 0.15299776 |
| 111 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.14928614 |
| 112 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.12574995 |
| 113 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.12359711 |
| 114 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.11932877 |
| 115 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.08032751 |
| 116 | Alcoholism_Homo sapiens_hsa05034 | 0.05225633 |

