MRPS25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 4. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.70686242
2energy coupled proton transport, down electrochemical gradient (GO:0015985)6.26238216
3ATP synthesis coupled proton transport (GO:0015986)6.26238216
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.63603021
5respiratory electron transport chain (GO:0022904)5.22522686
6electron transport chain (GO:0022900)5.09958980
7ribosomal small subunit assembly (GO:0000028)5.00358602
8viral transcription (GO:0019083)4.98173957
9translational termination (GO:0006415)4.87278420
10ribosomal small subunit biogenesis (GO:0042274)4.74598679
11protein neddylation (GO:0045116)4.74325835
12protein complex biogenesis (GO:0070271)4.64909260
13mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.57388126
14mitochondrial respiratory chain complex I assembly (GO:0032981)4.57388126
15NADH dehydrogenase complex assembly (GO:0010257)4.57388126
16maturation of SSU-rRNA (GO:0030490)4.53812660
17proteasome assembly (GO:0043248)4.46422235
18chaperone-mediated protein transport (GO:0072321)4.44309107
19mitochondrial respiratory chain complex assembly (GO:0033108)4.36760829
20cotranslational protein targeting to membrane (GO:0006613)4.35119222
21establishment of protein localization to mitochondrial membrane (GO:0090151)4.33850528
22SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.31862378
23protein targeting to ER (GO:0045047)4.30055733
24ribosomal large subunit biogenesis (GO:0042273)4.29005804
25translational elongation (GO:0006414)4.26763138
26establishment of protein localization to endoplasmic reticulum (GO:0072599)4.11913134
27protein localization to endoplasmic reticulum (GO:0070972)4.10146363
28cellular protein complex disassembly (GO:0043624)4.09092431
29formation of translation preinitiation complex (GO:0001731)4.07712370
30transcription elongation from RNA polymerase III promoter (GO:0006385)3.95270833
31termination of RNA polymerase III transcription (GO:0006386)3.95270833
32viral life cycle (GO:0019058)3.90009826
33cullin deneddylation (GO:0010388)3.80902991
34GTP biosynthetic process (GO:0006183)3.77573444
35L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.76515706
36translational initiation (GO:0006413)3.75785577
37establishment of integrated proviral latency (GO:0075713)3.69809576
38regulation of translational fidelity (GO:0006450)3.66742956
39respiratory chain complex IV assembly (GO:0008535)3.65037821
40translation (GO:0006412)3.64130595
41pseudouridine synthesis (GO:0001522)3.62926692
42nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.60837907
43regulation of mitochondrial translation (GO:0070129)3.54880614
44protein targeting to mitochondrion (GO:0006626)3.54280474
45negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.51749972
46oxidative phosphorylation (GO:0006119)3.51557019
47protein deneddylation (GO:0000338)3.46813521
48establishment of protein localization to mitochondrion (GO:0072655)3.42746765
49protein complex disassembly (GO:0043241)3.42464024
50DNA deamination (GO:0045006)3.37615566
51tricarboxylic acid cycle (GO:0006099)3.36447897
52cellular component biogenesis (GO:0044085)3.35861241
53DNA unwinding involved in DNA replication (GO:0006268)3.35615740
54DNA topological change (GO:0006265)3.35293970
55macromolecular complex disassembly (GO:0032984)3.32887389
56telomere maintenance via semi-conservative replication (GO:0032201)3.32689019
57purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.31531963
58guanosine-containing compound biosynthetic process (GO:1901070)3.31482636
59UTP biosynthetic process (GO:0006228)3.31382629
60spliceosomal snRNP assembly (GO:0000387)3.29347151
61purine nucleobase biosynthetic process (GO:0009113)3.29194144
627-methylguanosine mRNA capping (GO:0006370)3.28418908
63protein localization to mitochondrion (GO:0070585)3.28347630
64DNA strand elongation involved in DNA replication (GO:0006271)3.26361101
65spliceosomal complex assembly (GO:0000245)3.25187231
667-methylguanosine RNA capping (GO:0009452)3.25125825
67RNA capping (GO:0036260)3.25125825
68purine nucleoside triphosphate biosynthetic process (GO:0009145)3.24585565
69negative regulation of ligase activity (GO:0051352)3.24201379
70negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.24201379
71positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.23590735
72cytochrome complex assembly (GO:0017004)3.23262998
73ribonucleoprotein complex biogenesis (GO:0022613)3.22691505
74hydrogen ion transmembrane transport (GO:1902600)3.22506840
75nucleobase biosynthetic process (GO:0046112)3.19213117
76DNA strand elongation (GO:0022616)3.19019876
77viral mRNA export from host cell nucleus (GO:0046784)3.18625196
78ATP biosynthetic process (GO:0006754)3.18377254
79nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.17641628
80establishment of viral latency (GO:0019043)3.17480209
81regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.17108421
82regulation of cellular amino acid metabolic process (GO:0006521)3.16924029
83exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.13212057
84anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.10947316
85DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.10830479
86DNA replication initiation (GO:0006270)3.07609598
87cellular respiration (GO:0045333)3.04048214
88rRNA modification (GO:0000154)3.03901834
89ubiquinone biosynthetic process (GO:0006744)3.03777308
90intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.03748525
91signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.03748525
92ribonucleoside triphosphate biosynthetic process (GO:0009201)3.01959748
93rRNA processing (GO:0006364)3.01567513
94inner mitochondrial membrane organization (GO:0007007)3.01465721
95folic acid metabolic process (GO:0046655)3.00268433
96signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.99342163
97signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.99342163
98signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.99342163
99CENP-A containing nucleosome assembly (GO:0034080)2.99115540
100RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.99032743
101tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.99032743
102kinetochore organization (GO:0051383)2.98607274
103nuclear-transcribed mRNA catabolic process (GO:0000956)2.98267121
104DNA replication checkpoint (GO:0000076)2.97200568
105purine nucleoside monophosphate biosynthetic process (GO:0009127)2.95247951
106purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.95247951
107transcription from mitochondrial promoter (GO:0006390)2.93738695
108mitochondrial RNA metabolic process (GO:0000959)2.93278907
109ribosome biogenesis (GO:0042254)2.93079396
110signal transduction involved in DNA integrity checkpoint (GO:0072401)2.92780755
111signal transduction involved in DNA damage checkpoint (GO:0072422)2.92780755
112chromatin remodeling at centromere (GO:0031055)2.91875404
113CTP metabolic process (GO:0046036)2.91807787
114CTP biosynthetic process (GO:0006241)2.91807787
115signal transduction involved in cell cycle checkpoint (GO:0072395)2.89154430
116transcription-coupled nucleotide-excision repair (GO:0006283)2.89049012
117aerobic respiration (GO:0009060)2.88908525
118tRNA aminoacylation (GO:0043039)2.88735440
119amino acid activation (GO:0043038)2.88735440
120kinetochore assembly (GO:0051382)2.88305287
121rRNA metabolic process (GO:0016072)2.87156923
122mRNA catabolic process (GO:0006402)2.85032548
123tRNA aminoacylation for protein translation (GO:0006418)2.84916184
124ribosome assembly (GO:0042255)2.81077515
125IMP biosynthetic process (GO:0006188)2.78445229
126cellular ketone body metabolic process (GO:0046950)2.77788014
127negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.77293069
128oxaloacetate metabolic process (GO:0006107)2.77195073
129ubiquinone metabolic process (GO:0006743)2.76893973
130mitochondrial transport (GO:0006839)2.75873013
131peptidyl-histidine modification (GO:0018202)2.72936840
132nucleobase-containing small molecule interconversion (GO:0015949)2.72250232
133homocysteine metabolic process (GO:0050667)2.71162111
134ncRNA processing (GO:0034470)2.68126536
135telomere maintenance via recombination (GO:0000722)2.66383932
136RNA catabolic process (GO:0006401)2.66126206
137mitotic recombination (GO:0006312)2.65153804
138ketone body metabolic process (GO:1902224)2.65098239
139maturation of 5.8S rRNA (GO:0000460)2.64908265
140tetrahydrofolate metabolic process (GO:0046653)2.63978826
141negative regulation of RNA splicing (GO:0033119)2.60957371

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.83134672
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.14858343
3* EST1_17652178_ChIP-ChIP_JURKAT_Human4.07944314
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.06104943
5GABP_17652178_ChIP-ChIP_JURKAT_Human4.05593745
6E2F7_22180533_ChIP-Seq_HELA_Human4.02539723
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.68191174
8* HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.60331431
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.57630803
10* ETS1_20019798_ChIP-Seq_JURKAT_Human3.48758293
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.43938291
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.39818942
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.33672633
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.17212711
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.14131465
16* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.83190117
17* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.68454944
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.59394192
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.58943759
20* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.54981682
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.50668226
22* VDR_23849224_ChIP-Seq_CD4+_Human2.49156128
23DCP1A_22483619_ChIP-Seq_HELA_Human2.37739237
24RBPJ_22232070_ChIP-Seq_NCS_Mouse2.34876137
25SRF_21415370_ChIP-Seq_HL-1_Mouse2.33378409
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.25995611
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.23118176
28* XRN2_22483619_ChIP-Seq_HELA_Human2.21763535
29E2F1_18555785_ChIP-Seq_MESCs_Mouse2.11356106
30ELK1_19687146_ChIP-ChIP_HELA_Human2.10739069
31FOXP3_21729870_ChIP-Seq_TREG_Human2.09087754
32FOXM1_23109430_ChIP-Seq_U2OS_Human2.07407991
33YY1_21170310_ChIP-Seq_MESCs_Mouse2.05306817
34TTF2_22483619_ChIP-Seq_HELA_Human1.98027215
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.88848899
36ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.87251184
37* GABP_19822575_ChIP-Seq_HepG2_Human1.84282427
38* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.83041409
39YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77513203
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76236041
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.74688989
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.73159481
43FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.62812138
44ELF1_17652178_ChIP-ChIP_JURKAT_Human1.61041173
45KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.51056411
46FUS_26573619_Chip-Seq_HEK293_Human1.45235700
47ESR1_15608294_ChIP-ChIP_MCF-7_Human1.44841953
48MYC_18940864_ChIP-ChIP_HL60_Human1.44629088
49CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.44174307
50* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.39006022
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38465253
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.38371698
53RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38005088
54CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.37267317
55ZNF263_19887448_ChIP-Seq_K562_Human1.33738049
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33626129
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.33388739
58GATA1_22025678_ChIP-Seq_K562_Human1.31138588
59PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.30921685
60ELK1_22589737_ChIP-Seq_MCF10A_Human1.30080726
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.28234019
62IRF1_19129219_ChIP-ChIP_H3396_Human1.28180872
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.27761102
64TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.23172847
65MYCN_18555785_ChIP-Seq_MESCs_Mouse1.23095455
66EWS_26573619_Chip-Seq_HEK293_Human1.23014505
67MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.22604616
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22569019
69POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21754125
70HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.16320027
71FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.15783671
72ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15005828
73AR_21909140_ChIP-Seq_LNCAP_Human1.14733137
74CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.14634201
75CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13267925
76CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.11165992
77GBX2_23144817_ChIP-Seq_PC3_Human1.09029016
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07374029
79TAF15_26573619_Chip-Seq_HEK293_Human1.07096316
80CTCF_18555785_ChIP-Seq_MESCs_Mouse1.03228836
81NANOG_18555785_ChIP-Seq_MESCs_Mouse1.02170060
82CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01464508
83CIITA_25753668_ChIP-Seq_RAJI_Human1.00944397
84BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99136226
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98742153
86FOXP1_21924763_ChIP-Seq_HESCs_Human0.95994010
87MYC_22102868_ChIP-Seq_BL_Human0.92658127
88EZH2_22144423_ChIP-Seq_EOC_Human0.90885489
89SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90030937
90STAT3_1855785_ChIP-Seq_MESCs_Mouse0.89067857
91E2F1_21310950_ChIP-Seq_MCF-7_Human0.88569180
92CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87414287
93CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.86905350
94CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.86685080
95KLF4_18555785_ChIP-Seq_MESCs_Mouse0.85377535
96CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.84924113
97PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.84720853
98KDM5A_27292631_Chip-Seq_BREAST_Human0.84501861
99NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.84406423
100TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83954853
101FLI1_27457419_Chip-Seq_LIVER_Mouse0.83631621
102TBX5_21415370_ChIP-Seq_HL-1_Mouse0.83485294
103TFEB_21752829_ChIP-Seq_HELA_Human0.83360306
104SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.83276598
105KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.83268987
106ER_23166858_ChIP-Seq_MCF-7_Human0.82868716
107SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.82480867
108CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.79799666
109FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.79550321
110ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.78669606
111PCGF2_27294783_Chip-Seq_ESCs_Mouse0.78625470
112SOX2_18555785_ChIP-Seq_MESCs_Mouse0.77712141
113POU3F2_20337985_ChIP-ChIP_501MEL_Human0.77642413
114E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.77613220
115TP63_19390658_ChIP-ChIP_HaCaT_Human0.76927820
116SOX17_20123909_ChIP-Seq_XEN_Mouse0.76492716
117GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76206501
118NOTCH1_21737748_ChIP-Seq_TLL_Human0.74342181
119GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.72372323
120MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.70078242
121CTBP1_25329375_ChIP-Seq_LNCAP_Human0.70002225
122SOX2_16153702_ChIP-ChIP_HESCs_Human0.69013543
123* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68397882
124CTBP2_25329375_ChIP-Seq_LNCAP_Human0.66019437
125ZFP57_27257070_Chip-Seq_ESCs_Mouse0.64736102
126SALL4_22934838_ChIP-ChIP_CD34+_Human0.64570775
127SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.64084585
128TP53_22573176_ChIP-Seq_HFKS_Human0.63751193

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.09259420
2MP0003880_abnormal_central_pattern3.54247586
3MP0001529_abnormal_vocalization3.07602024
4MP0001905_abnormal_dopamine_level2.91534449
5MP0001968_abnormal_touch/_nociception2.56876768
6MP0002736_abnormal_nociception_after2.52514329
7MP0008995_early_reproductive_senescence2.40234591
8MP0001188_hyperpigmentation2.23105635
9MP0001986_abnormal_taste_sensitivity2.22857652
10MP0004957_abnormal_blastocyst_morpholog2.19379483
11MP0006036_abnormal_mitochondrial_physio2.17496766
12MP0003693_abnormal_embryo_hatching2.10059303
13MP0009046_muscle_twitch2.06473812
14MP0009745_abnormal_behavioral_response2.05587706
15MP0003806_abnormal_nucleotide_metabolis2.05067058
16MP0010094_abnormal_chromosome_stability2.03539783
17MP0002396_abnormal_hematopoietic_system2.03065808
18MP0006276_abnormal_autonomic_nervous2.01240839
19MP0003136_yellow_coat_color2.01001745
20MP0006035_abnormal_mitochondrial_morpho1.97397393
21MP0002064_seizures1.96522188
22MP0002735_abnormal_chemical_nociception1.96084793
23MP0002638_abnormal_pupillary_reflex1.94555455
24MP0008932_abnormal_embryonic_tissue1.92830097
25MP0004142_abnormal_muscle_tone1.92651494
26MP0002272_abnormal_nervous_system1.90972234
27MP0005409_darkened_coat_color1.87227891
28MP0002734_abnormal_mechanical_nocicepti1.86173109
29MP0004147_increased_porphyrin_level1.83050700
30MP0003635_abnormal_synaptic_transmissio1.83009365
31MP0008057_abnormal_DNA_replication1.77828452
32MP0004859_abnormal_synaptic_plasticity1.73540787
33MP0000372_irregular_coat_pigmentation1.64337061
34MP0009697_abnormal_copulation1.63796293
35MP0004270_analgesia1.60523563
36MP0006292_abnormal_olfactory_placode1.60483074
37MP0004215_abnormal_myocardial_fiber1.56682563
38MP0002837_dystrophic_cardiac_calcinosis1.55814260
39MP0002572_abnormal_emotion/affect_behav1.55411666
40MP0001764_abnormal_homeostasis1.51007035
41MP0002067_abnormal_sensory_capabilities1.49636103
42MP0003077_abnormal_cell_cycle1.47914309
43MP0001970_abnormal_pain_threshold1.47554135
44MP0005171_absent_coat_pigmentation1.47538831
45MP0005670_abnormal_white_adipose1.45107744
46MP0005451_abnormal_body_composition1.44398838
47MP0003123_paternal_imprinting1.43046860
48MP0004924_abnormal_behavior1.42916281
49MP0005386_behavior/neurological_phenoty1.42916281
50MP0001440_abnormal_grooming_behavior1.42285203
51MP0000749_muscle_degeneration1.35039819
52MP0002733_abnormal_thermal_nociception1.34157541
53MP0008877_abnormal_DNA_methylation1.32281335
54MP0002063_abnormal_learning/memory/cond1.32184386
55MP0004043_abnormal_pH_regulation1.27276407
56MP0005423_abnormal_somatic_nervous1.27250549
57MP0003111_abnormal_nucleus_morphology1.26001383
58MP0008058_abnormal_DNA_repair1.25820387
59MP0008007_abnormal_cellular_replicative1.22616614
60MP0000015_abnormal_ear_pigmentation1.18432241
61MP0001984_abnormal_olfaction1.17686292
62MP0002095_abnormal_skin_pigmentation1.16673223
63MP0001486_abnormal_startle_reflex1.15747803
64MP0002210_abnormal_sex_determination1.14437427
65MP0005332_abnormal_amino_acid1.14308761
66MP0000350_abnormal_cell_proliferation1.14016334
67MP0000313_abnormal_cell_death1.11788842
68MP0001485_abnormal_pinna_reflex1.11435046
69MP0001730_embryonic_growth_arrest1.10495109
70MP0003646_muscle_fatigue1.08205746
71MP0001661_extended_life_span1.07078830
72MP0005330_cardiomyopathy1.07068321
73MP0001697_abnormal_embryo_size1.07061786
74MP0005187_abnormal_penis_morphology1.06649611
75MP0000751_myopathy1.06332571
76MP0008775_abnormal_heart_ventricle1.06159584
77MP0004233_abnormal_muscle_weight1.05573262
78MP0005075_abnormal_melanosome_morpholog1.05138749
79MP0006072_abnormal_retinal_apoptosis1.04919742
80MP0001672_abnormal_embryogenesis/_devel1.04243140
81MP0005380_embryogenesis_phenotype1.04243140
82MP0003718_maternal_effect1.04113897
83MP0003984_embryonic_growth_retardation1.04019153
84MP0005266_abnormal_metabolism1.00641775
85MP0002751_abnormal_autonomic_nervous1.00267800
86MP0002822_catalepsy1.00084658
87MP0002088_abnormal_embryonic_growth/wei0.99979287
88MP0004145_abnormal_muscle_electrophysio0.98665435
89MP0005646_abnormal_pituitary_gland0.98264232
90MP0001929_abnormal_gametogenesis0.98171887
91MP0001346_abnormal_lacrimal_gland0.95007402
92MP0003787_abnormal_imprinting0.94779759
93MP0002163_abnormal_gland_morphology0.93720881
94MP0003890_abnormal_embryonic-extraembry0.92797637
95MP0004084_abnormal_cardiac_muscle0.92655307
96MP0002080_prenatal_lethality0.91364730
97MP0003786_premature_aging0.90554522
98MP0008872_abnormal_physiological_respon0.89716258
99MP0010386_abnormal_urinary_bladder0.89489564
100MP0001501_abnormal_sleep_pattern0.89216381
101MP0003698_abnormal_male_reproductive0.88910023
102MP0005174_abnormal_tail_pigmentation0.88164068
103MP0002184_abnormal_innervation0.87023288
104MP0002938_white_spotting0.86529907
105MP0003938_abnormal_ear_development0.85904580
106MP0001145_abnormal_male_reproductive0.85720725
107MP0008004_abnormal_stomach_pH0.85696578
108MP0002557_abnormal_social/conspecific_i0.85067581
109MP0002066_abnormal_motor_capabilities/c0.84309046
110MP0003137_abnormal_impulse_conducting0.84023874
111MP0003186_abnormal_redox_activity0.83486510
112MP0000653_abnormal_sex_gland0.82441320
113MP0005394_taste/olfaction_phenotype0.82289192
114MP0005499_abnormal_olfactory_system0.82289192
115MP0008569_lethality_at_weaning0.81824569
116MP0005408_hypopigmentation0.81425005
117MP0005551_abnormal_eye_electrophysiolog0.80805566
118MP0002160_abnormal_reproductive_system0.79820791
119MP0005636_abnormal_mineral_homeostasis0.78289059
120MP0003656_abnormal_erythrocyte_physiolo0.77633428
121MP0000631_abnormal_neuroendocrine_gland0.77388421
122MP0003567_abnormal_fetal_cardiomyocyte0.77343508
123MP0002269_muscular_atrophy0.77133601
124MP0002882_abnormal_neuron_morphology0.75245980
125MP0008789_abnormal_olfactory_epithelium0.75180437
126MP0003315_abnormal_perineum_morphology0.75168693
127MP0004036_abnormal_muscle_relaxation0.75006837
128MP0003121_genomic_imprinting0.74841918
129MP0004484_altered_response_of0.74533145
130MP0002229_neurodegeneration0.73415038
131MP0001963_abnormal_hearing_physiology0.72977001
132MP0005645_abnormal_hypothalamus_physiol0.70178228
133MP0000358_abnormal_cell_content/0.70082523
134MP0000778_abnormal_nervous_system0.70069177
135MP0009672_abnormal_birth_weight0.69932280
136MP0002752_abnormal_somatic_nervous0.68131899
137MP0004811_abnormal_neuron_physiology0.67729007
138MP0002139_abnormal_hepatobiliary_system0.66645796
139MP0000955_abnormal_spinal_cord0.66625547
140MP0004185_abnormal_adipocyte_glucose0.65040049
141MP0002106_abnormal_muscle_physiology0.65018964
142MP0005253_abnormal_eye_physiology0.64426840
143MP0002132_abnormal_respiratory_system0.59775127
144MP0002161_abnormal_fertility/fecundity0.59227217
145MP0005083_abnormal_biliary_tract0.59210745
146MP0005360_urolithiasis0.58601979
147MP0002234_abnormal_pharynx_morphology0.58577980
148MP0002084_abnormal_developmental_patter0.57597187
149MP0002085_abnormal_embryonic_tissue0.56911646

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.28787204
2Mitochondrial inheritance (HP:0001427)6.02358432
3Abnormal mitochondria in muscle tissue (HP:0008316)5.96203466
4Hepatocellular necrosis (HP:0001404)5.67175288
5Progressive macrocephaly (HP:0004481)5.33177043
6Increased CSF lactate (HP:0002490)5.29305904
7Increased hepatocellular lipid droplets (HP:0006565)5.07758587
8Acute encephalopathy (HP:0006846)5.02398929
9Hepatic necrosis (HP:0002605)4.60523033
10Lipid accumulation in hepatocytes (HP:0006561)4.37205928
11Abnormality of glycolysis (HP:0004366)4.35978635
12Increased serum pyruvate (HP:0003542)4.35978635
13Abnormality of cells of the erythroid lineage (HP:0012130)4.33854522
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.22494938
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.18733742
16Decreased activity of mitochondrial respiratory chain (HP:0008972)4.18733742
17Increased intramyocellular lipid droplets (HP:0012240)4.12008793
18Abnormal number of erythroid precursors (HP:0012131)4.09117017
19Renal Fanconi syndrome (HP:0001994)3.97791775
203-Methylglutaconic aciduria (HP:0003535)3.93790802
21Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.91049083
22Increased serum lactate (HP:0002151)3.69442720
23Exercise intolerance (HP:0003546)3.69370965
24Respiratory failure (HP:0002878)3.59331545
25Lactic acidosis (HP:0003128)3.40796404
26Exertional dyspnea (HP:0002875)3.38362108
27Increased muscle lipid content (HP:0009058)3.36150647
28Reticulocytopenia (HP:0001896)3.32348142
29Cerebral hypomyelination (HP:0006808)3.26116917
30Leukodystrophy (HP:0002415)3.24617860
31Optic disc pallor (HP:0000543)3.19313309
32Progressive muscle weakness (HP:0003323)3.11617912
33Cerebral edema (HP:0002181)3.04248169
34Chromsome breakage (HP:0040012)3.03361135
35Macrocytic anemia (HP:0001972)3.00957339
36Respiratory difficulties (HP:0002880)2.99125362
37Chromosomal breakage induced by crosslinking agents (HP:0003221)2.96778083
38Birth length less than 3rd percentile (HP:0003561)2.86164390
39Aplastic anemia (HP:0001915)2.70350566
40Emotional lability (HP:0000712)2.66675491
41Aplasia/Hypoplasia of the sacrum (HP:0008517)2.64526014
42Microvesicular hepatic steatosis (HP:0001414)2.63961094
43Cholecystitis (HP:0001082)2.51683155
44Abnormal gallbladder physiology (HP:0012438)2.51683155
45Pallor (HP:0000980)2.50759198
46Homocystinuria (HP:0002156)2.50397236
47Abnormality of homocysteine metabolism (HP:0010919)2.50397236
48Hyperglycinuria (HP:0003108)2.47392272
49Abnormality of renal resorption (HP:0011038)2.47325941
50CNS demyelination (HP:0007305)2.46562002
51Neuroendocrine neoplasm (HP:0100634)2.43846526
52Myokymia (HP:0002411)2.40047960
53Hyperglycinemia (HP:0002154)2.37637242
54Abnormality of reticulocytes (HP:0004312)2.29509721
55Focal motor seizures (HP:0011153)2.27100707
56Lethargy (HP:0001254)2.26134569
57Hypothermia (HP:0002045)2.17255116
58CNS hypomyelination (HP:0003429)2.15605592
59Pheochromocytoma (HP:0002666)2.14806532
60Sensory axonal neuropathy (HP:0003390)2.14669995
61Breast hypoplasia (HP:0003187)2.14196983
62Methylmalonic aciduria (HP:0012120)2.11846205
63Abnormality of methionine metabolism (HP:0010901)2.11705072
64X-linked dominant inheritance (HP:0001423)2.10011848
65Dicarboxylic aciduria (HP:0003215)2.08007673
66Abnormality of dicarboxylic acid metabolism (HP:0010995)2.08007673
67Nausea (HP:0002018)2.07487820
68Abnormality of serine family amino acid metabolism (HP:0010894)2.06801713
69Abnormality of glycine metabolism (HP:0010895)2.06801713
70Methylmalonic acidemia (HP:0002912)2.03853781
71Oral leukoplakia (HP:0002745)2.02756287
72Abnormality of sulfur amino acid metabolism (HP:0004339)2.01740979
73Ketoacidosis (HP:0001993)1.99661316
74Postnatal microcephaly (HP:0005484)1.97811534
75Abnormality of alanine metabolism (HP:0010916)1.96915790
76Hyperalaninemia (HP:0003348)1.96915790
77Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.96915790
78Rhabdomyolysis (HP:0003201)1.96500085
79Abnormality of chromosome stability (HP:0003220)1.95565023
80Atonic seizures (HP:0010819)1.95081601
81Abnormal hemoglobin (HP:0011902)1.94580873
82Myoglobinuria (HP:0002913)1.94408016
83Ragged-red muscle fibers (HP:0003200)1.92600640
84Colon cancer (HP:0003003)1.91081317
85Abnormality of the preputium (HP:0100587)1.90591907
86Metabolic acidosis (HP:0001942)1.90130476
87Generalized aminoaciduria (HP:0002909)1.88969513
88Hyperammonemia (HP:0001987)1.87090470
89Abnormal protein glycosylation (HP:0012346)1.83155696
90Abnormal glycosylation (HP:0012345)1.83155696
91Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.83155696
92Abnormal protein N-linked glycosylation (HP:0012347)1.83155696
93Pancytopenia (HP:0001876)1.82361413
94Gliosis (HP:0002171)1.81340452
95Abnormality of serum amino acid levels (HP:0003112)1.80909663
96Delusions (HP:0000746)1.80884529
97Meckel diverticulum (HP:0002245)1.80416251
98Hyperventilation (HP:0002883)1.80074662
99Hypoglycemic coma (HP:0001325)1.80042207
100Epileptic encephalopathy (HP:0200134)1.79534476
101Hypobetalipoproteinemia (HP:0003563)1.78476390
102Broad-based gait (HP:0002136)1.76865105
103Abnormality of cochlea (HP:0000375)1.76859980
104Abnormality of DNA repair (HP:0003254)1.76748234
105Truncus arteriosus (HP:0001660)1.76326371
106Medial flaring of the eyebrow (HP:0010747)1.76158879
107Premature ovarian failure (HP:0008209)1.75850732
108Hyperphosphaturia (HP:0003109)1.74763724
109Limb hypertonia (HP:0002509)1.74605632
110Carpal bone hypoplasia (HP:0001498)1.74004696
111Spastic paraparesis (HP:0002313)1.73596612
112Aplasia/Hypoplasia of the uvula (HP:0010293)1.71001221
113Gout (HP:0001997)1.70454576
114Abnormality of vitamin B metabolism (HP:0004340)1.69829411
115Abnormality of the ileum (HP:0001549)1.69685853
116Abnormality of the vitamin B12 metabolism (HP:0004341)1.69371276
117Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.68695070
118Rough bone trabeculation (HP:0100670)1.66353350
119Ketosis (HP:0001946)1.65413589
120Premature graying of hair (HP:0002216)1.65366087
121Testicular atrophy (HP:0000029)1.64062732
122Vomiting (HP:0002013)1.63986705
123Reticulocytosis (HP:0001923)1.63926106
124Limb dystonia (HP:0002451)1.63903517
125Renal cortical cysts (HP:0000803)1.63372025
126Pancreatic cysts (HP:0001737)1.61846112
127Neoplasm of the peripheral nervous system (HP:0100007)1.61093875
128Parakeratosis (HP:0001036)1.60335725
129Aplasia/hypoplasia of the uterus (HP:0008684)1.58412459
130Abnormality of the labia minora (HP:0012880)1.58280066
131Absent thumb (HP:0009777)1.57341803
132Progressive inability to walk (HP:0002505)1.56865279
133Unsteady gait (HP:0002317)1.56160139
134Myotonia (HP:0002486)1.55470036
135Progressive external ophthalmoplegia (HP:0000590)1.54763095
136Stenosis of the external auditory canal (HP:0000402)1.54560025
137Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.54329120
138Agnosia (HP:0010524)1.54288031
139Poor suck (HP:0002033)1.53492260
140Type I transferrin isoform profile (HP:0003642)1.53163538
141Retinal dysplasia (HP:0007973)1.51344723
142Abnormal pupillary function (HP:0007686)1.48599814
143Esophageal neoplasm (HP:0100751)1.48287532
144Neoplasm of head and neck (HP:0012288)1.48287532
145Glycosuria (HP:0003076)1.47795009
146Abnormality of urine glucose concentration (HP:0011016)1.47795009
147Absence seizures (HP:0002121)1.47650073
148Congenital primary aphakia (HP:0007707)1.47246524
149Dialeptic seizures (HP:0011146)1.45715986
150Nephrogenic diabetes insipidus (HP:0009806)1.44691507
151Gait imbalance (HP:0002141)1.44657849
152Microretrognathia (HP:0000308)1.42250770

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK24.66842325
2CASK4.44729831
3MAP3K123.24534502
4NME23.12642085
5BUB13.09541555
6EIF2AK12.93091989
7CDK192.78996439
8STK162.45569706
9NME12.42097837
10SRPK12.41014699
11TLK12.40808434
12EIF2AK32.35884389
13WEE12.33091775
14VRK12.10066379
15VRK22.09061190
16TSSK62.07131800
17MAP2K71.98195555
18MAP4K21.95729387
19PBK1.87043544
20STK391.77938669
21CDC71.74001007
22RPS6KB21.73709375
23CCNB11.70284266
24MUSK1.68117289
25OXSR11.66902327
26LIMK11.50208017
27EEF2K1.49079582
28ARAF1.47279228
29PLK21.40303478
30MAPKAPK51.33871213
31MAP3K41.33542391
32TNIK1.33343273
33PASK1.33306402
34GRK51.25927328
35PNCK1.25050282
36PLK41.21087438
37BRAF1.19398651
38MYLK1.18669187
39CHEK11.14293848
40CDK81.11581421
41NEK21.11420586
42PLK31.08359438
43MKNK11.08282934
44DAPK11.08010322
45BMPR1B1.04225864
46MST40.96905467
47ILK0.95860611
48MAPK130.94338592
49ACVR1B0.93165410
50GRK70.93119833
51BRSK20.92687420
52RAF10.91733492
53YES10.90928094
54PLK10.89622427
55FLT30.88386384
56PKN20.88062313
57CSNK1G30.87393831
58EPHA40.85674278
59CDK40.84570414
60TESK20.83251707
61TNK20.83082650
62WNK40.82480856
63CSNK1E0.81581792
64CDK20.80569693
65ATM0.80002430
66CDK10.79025622
67SIK20.78962176
68ADRBK20.78846343
69MAP3K130.78036689
70PDK30.76535822
71PDK40.76535822
72AURKA0.76527579
73AKT20.75275703
74MINK10.74137788
75NEK10.73072835
76MAPKAPK30.72338539
77CAMK2B0.70266072
78WNK30.69666968
79DAPK20.69309060
80DAPK30.68730944
81BCKDK0.68150112
82NTRK30.64040601
83CSNK2A20.62297743
84MAP2K20.62200954
85CAMK2A0.61881832
86UHMK10.61677537
87AURKB0.60956044
88STK40.60727201
89ALK0.59930787
90NUAK10.59328255
91MKNK20.55248698
92DYRK30.55101667
93CLK10.54505437
94DYRK20.54471709
95CSNK1G20.54216105
96CDK140.54200350
97ADRBK10.54152334
98MAP3K110.52261683
99BMPR20.51751980
100CSNK2A10.50987819
101ABL20.50185987
102RPS6KA50.49716575
103CHEK20.49595432
104TTK0.49576567
105PRKDC0.49334065
106CDK180.47906555
107FES0.47637922
108MAP3K80.47266567
109MAPK110.47188548
110CAMK2D0.47170886
111TGFBR10.46735576
112NEK60.46354358
113CDK11A0.45677337
114CSNK1G10.45505109
115BCR0.44322248
116RPS6KB10.44257204
117CDK150.44217144
118CAMK2G0.42945590
119CSNK1A1L0.42728907
120EIF2AK20.42338743
121ZAK0.42174823
122MAPK120.41651041
123CDK70.41176285
124ATR0.40935258
125PRKD30.40737305
126MAP3K70.40519130
127MAP2K40.40068843
128GSK3B0.39821235
129MAPK140.39788820
130PIM20.39489258
131CAMK1G0.38901557
132TESK10.38029384
133TRIB30.36905606
134CDK30.36702770
135OBSCN0.36622423
136ROCK20.35413460
137BRSK10.33247391
138SCYL20.32022173
139PRKACA0.30788165
140PHKG20.30395124
141PHKG10.30395124
142PRKCG0.30202288
143TEC0.30105000
144PAK10.29002250
145CDK50.27808215

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.93686647
2Ribosome_Homo sapiens_hsa030104.71609110
3Parkinsons disease_Homo sapiens_hsa050124.39736788
4Proteasome_Homo sapiens_hsa030503.99010123
5RNA polymerase_Homo sapiens_hsa030203.26897802
6Huntingtons disease_Homo sapiens_hsa050163.22937736
7Alzheimers disease_Homo sapiens_hsa050103.15525926
8DNA replication_Homo sapiens_hsa030303.06410093
9Mismatch repair_Homo sapiens_hsa034302.71456338
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.48222821
11Protein export_Homo sapiens_hsa030602.38724149
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.35513600
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.29186322
14Homologous recombination_Homo sapiens_hsa034402.28020685
15Spliceosome_Homo sapiens_hsa030402.11069591
16Pyrimidine metabolism_Homo sapiens_hsa002402.00821608
17Cardiac muscle contraction_Homo sapiens_hsa042602.00586002
18Nucleotide excision repair_Homo sapiens_hsa034201.89554323
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.64784270
20Collecting duct acid secretion_Homo sapiens_hsa049661.59264698
21Basal transcription factors_Homo sapiens_hsa030221.59007599
22Base excision repair_Homo sapiens_hsa034101.58652411
23RNA transport_Homo sapiens_hsa030131.58317405
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.57679665
25RNA degradation_Homo sapiens_hsa030181.42669509
26Purine metabolism_Homo sapiens_hsa002301.34435446
27Butanoate metabolism_Homo sapiens_hsa006501.31807663
28Synaptic vesicle cycle_Homo sapiens_hsa047211.30546616
29Nicotine addiction_Homo sapiens_hsa050331.27232593
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.21345064
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.21204364
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.20206665
33Fanconi anemia pathway_Homo sapiens_hsa034601.18567002
34Arginine biosynthesis_Homo sapiens_hsa002201.12489785
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.10250815
36Vibrio cholerae infection_Homo sapiens_hsa051101.08211813
37Non-homologous end-joining_Homo sapiens_hsa034501.08026212
38Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.07895195
39Fatty acid metabolism_Homo sapiens_hsa012121.07703178
40Cell cycle_Homo sapiens_hsa041101.02206504
41Cyanoamino acid metabolism_Homo sapiens_hsa004601.00046085
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99172387
43SNARE interactions in vesicular transport_Homo sapiens_hsa041300.95389895
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.86475001
45Fatty acid elongation_Homo sapiens_hsa000620.82851709
46Arginine and proline metabolism_Homo sapiens_hsa003300.79764454
47Fatty acid degradation_Homo sapiens_hsa000710.77513250
48Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.77404300
49Selenocompound metabolism_Homo sapiens_hsa004500.76384787
50Serotonergic synapse_Homo sapiens_hsa047260.75039863
51Oocyte meiosis_Homo sapiens_hsa041140.72131711
52Folate biosynthesis_Homo sapiens_hsa007900.71687567
53Vitamin B6 metabolism_Homo sapiens_hsa007500.69849223
54Peroxisome_Homo sapiens_hsa041460.64513007
55Phototransduction_Homo sapiens_hsa047440.64206674
56mRNA surveillance pathway_Homo sapiens_hsa030150.64166005
57Metabolic pathways_Homo sapiens_hsa011000.63961020
58Pyruvate metabolism_Homo sapiens_hsa006200.63323606
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.61132519
60Epstein-Barr virus infection_Homo sapiens_hsa051690.60745356
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.60707752
62Lysine degradation_Homo sapiens_hsa003100.60296615
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59225568
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57459289
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.57220779
66Alcoholism_Homo sapiens_hsa050340.57154766
67GABAergic synapse_Homo sapiens_hsa047270.56949384
68Morphine addiction_Homo sapiens_hsa050320.54979326
69Vitamin digestion and absorption_Homo sapiens_hsa049770.54681776
70Dopaminergic synapse_Homo sapiens_hsa047280.53073289
71One carbon pool by folate_Homo sapiens_hsa006700.52239844
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51542970
73Carbon metabolism_Homo sapiens_hsa012000.50850915
74Nitrogen metabolism_Homo sapiens_hsa009100.49901059
75Phenylalanine metabolism_Homo sapiens_hsa003600.49850232
76Amphetamine addiction_Homo sapiens_hsa050310.49765489
77Tryptophan metabolism_Homo sapiens_hsa003800.48703562
78Taste transduction_Homo sapiens_hsa047420.47506884
79Glutamatergic synapse_Homo sapiens_hsa047240.44245273
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.43810354
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41855947
82Olfactory transduction_Homo sapiens_hsa047400.41521554
83Systemic lupus erythematosus_Homo sapiens_hsa053220.41308524
84Pentose phosphate pathway_Homo sapiens_hsa000300.39310064
85Long-term depression_Homo sapiens_hsa047300.38678828
86Circadian entrainment_Homo sapiens_hsa047130.37470491
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37000517
88Other glycan degradation_Homo sapiens_hsa005110.36348946
89Glutathione metabolism_Homo sapiens_hsa004800.35922324
90Fat digestion and absorption_Homo sapiens_hsa049750.35508597
91Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34748881
92Rheumatoid arthritis_Homo sapiens_hsa053230.34307778
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33640903
94Long-term potentiation_Homo sapiens_hsa047200.33507885
95Calcium signaling pathway_Homo sapiens_hsa040200.33494005
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31819645
97Sulfur relay system_Homo sapiens_hsa041220.31757087
98Ether lipid metabolism_Homo sapiens_hsa005650.31462978
99beta-Alanine metabolism_Homo sapiens_hsa004100.31318766
100N-Glycan biosynthesis_Homo sapiens_hsa005100.30143273
101Steroid biosynthesis_Homo sapiens_hsa001000.28235171
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27322905
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.27277014
104Cholinergic synapse_Homo sapiens_hsa047250.27220992
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.27047377
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.25122424
107Biosynthesis of amino acids_Homo sapiens_hsa012300.23969545
108Arachidonic acid metabolism_Homo sapiens_hsa005900.23689905
109Linoleic acid metabolism_Homo sapiens_hsa005910.23073868
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22712917
111Chemical carcinogenesis_Homo sapiens_hsa052040.22571001
112Gastric acid secretion_Homo sapiens_hsa049710.22442102
113Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.21835013
114Primary bile acid biosynthesis_Homo sapiens_hsa001200.21438956
1152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.20573582
116Glucagon signaling pathway_Homo sapiens_hsa049220.20349774
117Drug metabolism - other enzymes_Homo sapiens_hsa009830.20321858
118Propanoate metabolism_Homo sapiens_hsa006400.19730197
119Salivary secretion_Homo sapiens_hsa049700.19328901
120Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.18810954
121Cocaine addiction_Homo sapiens_hsa050300.17087871
122Phagosome_Homo sapiens_hsa041450.16572247
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.16272581
124Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.14709741
125Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.14436460
126Regulation of autophagy_Homo sapiens_hsa041400.13695643
127Gap junction_Homo sapiens_hsa045400.13692081
128Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.13131947
129Maturity onset diabetes of the young_Homo sapiens_hsa049500.12574068
130Retinol metabolism_Homo sapiens_hsa008300.12557006
131ABC transporters_Homo sapiens_hsa020100.12437297
132p53 signaling pathway_Homo sapiens_hsa041150.11175839
133Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.11063259
134Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.11008538
135Glycerolipid metabolism_Homo sapiens_hsa005610.10364272
136Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.07518736
137Tyrosine metabolism_Homo sapiens_hsa003500.06956860
138Sphingolipid metabolism_Homo sapiens_hsa006000.06531511
139Insulin secretion_Homo sapiens_hsa049110.06216698
140Fructose and mannose metabolism_Homo sapiens_hsa000510.05085910
141Melanoma_Homo sapiens_hsa052180.04613319

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