MRPS26

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. This gene lies adjacent to and downstream of the gonadotropin-releasing hormone precursor gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.69361128
2ribosomal small subunit biogenesis (GO:0042274)6.33350895
3viral transcription (GO:0019083)5.72283889
4maturation of SSU-rRNA (GO:0030490)5.63952573
5proteasome assembly (GO:0043248)5.62092231
6translational termination (GO:0006415)5.53968930
7ribosomal small subunit assembly (GO:0000028)5.27760756
8ribosomal large subunit biogenesis (GO:0042273)5.21591635
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.81136703
10transcription elongation from RNA polymerase III promoter (GO:0006385)4.78998113
11termination of RNA polymerase III transcription (GO:0006386)4.78998113
12translational elongation (GO:0006414)4.78407207
13protein maturation by protein folding (GO:0022417)4.75882675
14cotranslational protein targeting to membrane (GO:0006613)4.75393308
15protein targeting to ER (GO:0045047)4.71600972
16ribonucleoprotein complex biogenesis (GO:0022613)4.50331935
17protein localization to endoplasmic reticulum (GO:0070972)4.49042022
18establishment of protein localization to endoplasmic reticulum (GO:0072599)4.48737653
19translational initiation (GO:0006413)4.48515135
20cellular protein complex disassembly (GO:0043624)4.42968172
21telomere maintenance via semi-conservative replication (GO:0032201)4.41835796
22viral life cycle (GO:0019058)4.33479496
23nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.22105479
24translation (GO:0006412)4.15477714
25negative regulation of telomerase activity (GO:0051974)4.13883363
26pseudouridine synthesis (GO:0001522)4.12221696
27DNA strand elongation involved in DNA replication (GO:0006271)4.11945269
28mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.08366791
29spliceosomal snRNP assembly (GO:0000387)4.03284250
30rRNA processing (GO:0006364)3.97398317
31deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.97064079
32DNA strand elongation (GO:0022616)3.95344227
33DNA replication checkpoint (GO:0000076)3.94108213
34rRNA modification (GO:0000154)3.90948335
35regulation of mitochondrial translation (GO:0070129)3.89372163
36regulation of helicase activity (GO:0051095)3.88063874
37cellular component biogenesis (GO:0044085)3.87321755
38ATP synthesis coupled proton transport (GO:0015986)3.84688266
39energy coupled proton transport, down electrochemical gradient (GO:0015985)3.84688266
40protein complex disassembly (GO:0043241)3.83376971
41rRNA metabolic process (GO:0016072)3.82720630
42DNA replication initiation (GO:0006270)3.81807311
437-methylguanosine mRNA capping (GO:0006370)3.80729832
44ribosome assembly (GO:0042255)3.79831607
45pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.79622622
46mitochondrial respiratory chain complex assembly (GO:0033108)3.79487657
47telomere maintenance via recombination (GO:0000722)3.72411015
48L-serine metabolic process (GO:0006563)3.72409898
49RNA capping (GO:0036260)3.70839216
507-methylguanosine RNA capping (GO:0009452)3.70839216
51pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.69851373
52macromolecular complex disassembly (GO:0032984)3.68875914
53exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.64640396
54negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.63249229
55transcription-coupled nucleotide-excision repair (GO:0006283)3.61938221
56ribosome biogenesis (GO:0042254)3.61561893
57mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.60137141
58guanosine-containing compound biosynthetic process (GO:1901070)3.58510613
59UTP biosynthetic process (GO:0006228)3.57705788
60spliceosomal complex assembly (GO:0000245)3.57078674
61peptidyl-arginine omega-N-methylation (GO:0035247)3.56856662
62nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.56038022
63protein targeting to mitochondrion (GO:0006626)3.54448734
64CENP-A containing nucleosome assembly (GO:0034080)3.54253847
65deoxyribonucleotide biosynthetic process (GO:0009263)3.52541492
66telomere maintenance via telomere lengthening (GO:0010833)3.51868478
67heterochromatin organization (GO:0070828)3.50801585
68chromatin remodeling at centromere (GO:0031055)3.50463335
69establishment of protein localization to mitochondrion (GO:0072655)3.49368000
70pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.48361063
71CTP biosynthetic process (GO:0006241)3.47493851
72CTP metabolic process (GO:0046036)3.47493851
73establishment of integrated proviral latency (GO:0075713)3.45948896
74pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.40854716
75transcription from RNA polymerase I promoter (GO:0006360)3.40737718
76regulation of nuclear cell cycle DNA replication (GO:0033262)3.39291638
77termination of RNA polymerase I transcription (GO:0006363)3.37257693
78histone arginine methylation (GO:0034969)3.36517124
79negative regulation of ligase activity (GO:0051352)3.36034102
80negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.36034102
81positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.34961910
82GTP biosynthetic process (GO:0006183)3.33036346
83deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.32953971
84metallo-sulfur cluster assembly (GO:0031163)3.32081787
85iron-sulfur cluster assembly (GO:0016226)3.32081787
86deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.31760800
87transcription elongation from RNA polymerase I promoter (GO:0006362)3.31064971
88regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.30665171
89proline biosynthetic process (GO:0006561)3.28956233
90UTP metabolic process (GO:0046051)3.28571364
91regulation of telomerase activity (GO:0051972)3.28564004
92pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.27385420
93anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.27275664
94mitotic recombination (GO:0006312)3.25915192
95nuclear-transcribed mRNA catabolic process (GO:0000956)3.25073014
96mitochondrial DNA replication (GO:0006264)3.24557235
97formation of translation preinitiation complex (GO:0001731)3.23796447
98kinetochore assembly (GO:0051382)3.23549058
99regulation of cellular amino acid metabolic process (GO:0006521)3.23359359
100cullin deneddylation (GO:0010388)3.23285004
101protein deneddylation (GO:0000338)3.23120090
102establishment of protein localization to mitochondrial membrane (GO:0090151)3.22428494
103negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.18917540
104respiratory electron transport chain (GO:0022904)3.18738628
105L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.16232219
106tRNA methylation (GO:0030488)3.16116535
107signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.15832327
108signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.15832327
109signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.15832327
110chaperone-mediated protein transport (GO:0072321)3.15457582
111protein complex biogenesis (GO:0070271)3.14530848
112mitochondrial respiratory chain complex I assembly (GO:0032981)3.13544260
113NADH dehydrogenase complex assembly (GO:0010257)3.13544260
114mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.13544260
115DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.13435841
116maturation of 5.8S rRNA (GO:0000460)3.13219086
117ncRNA processing (GO:0034470)3.11637666
118electron transport chain (GO:0022900)3.11532724
119negative regulation of telomere maintenance (GO:0032205)3.10440570
120protein localization to mitochondrion (GO:0070585)3.10085580
121nucleotide-excision repair, DNA gap filling (GO:0006297)3.09488446
122signal transduction involved in DNA damage checkpoint (GO:0072422)3.09023610
123signal transduction involved in DNA integrity checkpoint (GO:0072401)3.09023610
124tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.08599767
125RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.08599767
126mRNA catabolic process (GO:0006402)3.07930090
127pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.05945469
128oxidative phosphorylation (GO:0006119)3.05550507
129nucleobase-containing small molecule interconversion (GO:0015949)3.03737761
130base-excision repair, AP site formation (GO:0006285)2.96869268
131mitochondrial RNA metabolic process (GO:0000959)2.96646577
132GDP-mannose metabolic process (GO:0019673)2.94928861
1332-deoxyribonucleotide biosynthetic process (GO:0009265)2.94388083
134deoxyribose phosphate biosynthetic process (GO:0046385)2.94388083
135DNA unwinding involved in DNA replication (GO:0006268)2.94093854
136peptidyl-histidine modification (GO:0018202)2.89755888
137deoxyribonucleotide catabolic process (GO:0009264)2.87084771
138transcription from mitochondrial promoter (GO:0006390)2.86852644
139tRNA modification (GO:0006400)2.86771221
140regulation of telomere maintenance via telomerase (GO:0032210)2.85202858

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.98044991
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.67535566
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.46330092
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.14123742
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.01066794
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.99842041
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.76344115
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.73326395
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.50454460
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.38933101
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.34520188
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.32837262
13MYC_18358816_ChIP-ChIP_MESCs_Mouse3.27824762
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.26309060
15CREB1_15753290_ChIP-ChIP_HEK293T_Human3.15028386
16MYC_19079543_ChIP-ChIP_MESCs_Mouse3.12507100
17MYC_19030024_ChIP-ChIP_MESCs_Mouse3.01694155
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.92125270
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.81769520
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.65905898
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.64643895
22XRN2_22483619_ChIP-Seq_HELA_Human2.59238117
23VDR_23849224_ChIP-Seq_CD4+_Human2.57624312
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.32829138
25DCP1A_22483619_ChIP-Seq_HELA_Human2.32745150
26YY1_21170310_ChIP-Seq_MESCs_Mouse2.30656655
27THAP11_20581084_ChIP-Seq_MESCs_Mouse2.27441527
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.23860665
29TTF2_22483619_ChIP-Seq_HELA_Human2.22017577
30FOXP3_21729870_ChIP-Seq_TREG_Human2.13912527
31* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.10948541
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.99952563
33* GABP_19822575_ChIP-Seq_HepG2_Human1.94118601
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.86047857
35ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.85371376
36PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.85215166
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.82872433
38ELK1_19687146_ChIP-ChIP_HELA_Human1.80811254
39FOXM1_23109430_ChIP-Seq_U2OS_Human1.77636754
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.70671473
41ZNF263_19887448_ChIP-Seq_K562_Human1.69438923
42* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.67747004
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66602893
44TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.57719143
45MYCN_18555785_ChIP-Seq_MESCs_Mouse1.57551858
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.55384587
47* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.53825932
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.53641252
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.53339009
50TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52641668
51ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.49986883
52TET1_21451524_ChIP-Seq_MESCs_Mouse1.49916975
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.49484083
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.45793472
55TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.45618194
56PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.44681523
57YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43988256
58MYC_18940864_ChIP-ChIP_HL60_Human1.38228492
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37795605
60ELK1_22589737_ChIP-Seq_MCF10A_Human1.36521689
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34645005
62KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.34133121
63CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.33835484
64P68_20966046_ChIP-Seq_HELA_Human1.32553658
65HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.31959507
66CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.29646832
67* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.27225571
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26004523
69ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.23472574
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23332349
71CIITA_25753668_ChIP-Seq_RAJI_Human1.21203332
72VDR_21846776_ChIP-Seq_THP-1_Human1.21183295
73LXR_22292898_ChIP-Seq_THP-1_Human1.18870190
74ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.16870528
75* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.15856858
76ELF1_20517297_ChIP-Seq_JURKAT_Human1.15410008
77KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14096692
78ESR1_15608294_ChIP-ChIP_MCF-7_Human1.14048298
79E2F1_21310950_ChIP-Seq_MCF-7_Human1.13614559
80YY1_22570637_ChIP-Seq_MALME-3M_Human1.13579582
81CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13300246
82ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.12090450
83KDM5A_27292631_Chip-Seq_BREAST_Human1.09618694
84BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.07909284
85CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07312572
86SRY_22984422_ChIP-ChIP_TESTIS_Rat1.06049991
87* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.05319171
88DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02462781
89SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.02411490
90SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.02283758
91KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.01157210
92KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.01157210
93KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.01157210
94DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99575336
95SOX2_18555785_ChIP-Seq_MESCs_Mouse0.97642490
96* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.95989534
97BCL6_27268052_Chip-Seq_Bcells_Human0.95427110
98E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95178623
99ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.94363770
100SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.94032599
101PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93929661
102PHF8_20622854_ChIP-Seq_HELA_Human0.93866015
103SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93828301
104HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92268875
105SA1_27219007_Chip-Seq_ERYTHROID_Human0.91606619
106SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.89886442
107IRF1_19129219_ChIP-ChIP_H3396_Human0.88950665
108CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.88631866
109GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84650170
110EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.81730904
111FOXP1_21924763_ChIP-Seq_HESCs_Human0.81514384
112* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81175919
113AR_21909140_ChIP-Seq_LNCAP_Human0.79985901
114KLF4_18555785_ChIP-Seq_MESCs_Mouse0.79493917
115STAT3_1855785_ChIP-Seq_MESCs_Mouse0.77114322
116SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.76836550
117POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.75454365
118SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.74104100
119NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.73840201
120SPI1_23547873_ChIP-Seq_NB4_Human0.72133431
121SOX2_18692474_ChIP-Seq_MEFs_Mouse0.71254148
122CTCF_26484167_Chip-Seq_Bcells_Mouse0.70742930
123TP63_19390658_ChIP-ChIP_HaCaT_Human0.70508001
124OCT4_18692474_ChIP-Seq_MEFs_Mouse0.68658375
125TBX5_21415370_ChIP-Seq_HL-1_Mouse0.68327675

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.76982867
2MP0009379_abnormal_foot_pigmentation4.03963764
3MP0006292_abnormal_olfactory_placode3.73017503
4MP0003111_abnormal_nucleus_morphology3.45851158
5MP0004957_abnormal_blastocyst_morpholog3.28141337
6MP0010094_abnormal_chromosome_stability3.23149371
7MP0003136_yellow_coat_color3.14109988
8MP0008058_abnormal_DNA_repair3.13641655
9MP0008932_abnormal_embryonic_tissue2.85010381
10MP0008057_abnormal_DNA_replication2.79472639
11MP0003077_abnormal_cell_cycle2.78335762
12MP0001188_hyperpigmentation2.52644405
13MP0003718_maternal_effect2.48563115
14MP0005409_darkened_coat_color2.37019555
15MP0010030_abnormal_orbit_morphology2.23113891
16MP0003786_premature_aging2.19331138
17MP0009840_abnormal_foam_cell2.15716487
18MP0004381_abnormal_hair_follicle2.14516428
19MP0001986_abnormal_taste_sensitivity1.97405504
20MP0008877_abnormal_DNA_methylation1.95459060
21MP0002160_abnormal_reproductive_system1.95441592
22MP0008007_abnormal_cellular_replicative1.88658780
23MP0005379_endocrine/exocrine_gland_phen1.81142321
24MP0003315_abnormal_perineum_morphology1.79061801
25MP0004270_analgesia1.75124497
26MP0004858_abnormal_nervous_system1.70867876
27MP0005075_abnormal_melanosome_morpholog1.69161981
28MP0002132_abnormal_respiratory_system1.68028066
29MP0000537_abnormal_urethra_morphology1.67117725
30MP0003880_abnormal_central_pattern1.65073152
31MP0004147_increased_porphyrin_level1.62799262
32MP0002102_abnormal_ear_morphology1.62527669
33MP0001346_abnormal_lacrimal_gland1.60941499
34MP0000372_irregular_coat_pigmentation1.54528725
35MP0005670_abnormal_white_adipose1.51204921
36MP0001529_abnormal_vocalization1.47086156
37MP0004142_abnormal_muscle_tone1.45404220
38MP0000566_synostosis1.45253945
39MP0009672_abnormal_birth_weight1.43262359
40MP0006035_abnormal_mitochondrial_morpho1.42929518
41MP0001905_abnormal_dopamine_level1.37811270
42MP0005389_reproductive_system_phenotype1.37227982
43MP0002736_abnormal_nociception_after1.37194094
44MP0002249_abnormal_larynx_morphology1.36747275
45MP0005174_abnormal_tail_pigmentation1.35538910
46MP0009333_abnormal_splenocyte_physiolog1.34700496
47MP0002210_abnormal_sex_determination1.34008063
48MP0006036_abnormal_mitochondrial_physio1.31849480
49MP0004133_heterotaxia1.30115081
50MP0002277_abnormal_respiratory_mucosa1.29813951
51MP0003123_paternal_imprinting1.29138412
52MP0002822_catalepsy1.28484170
53MP0000490_abnormal_crypts_of1.25895948
54MP0003938_abnormal_ear_development1.25308842
55MP0000015_abnormal_ear_pigmentation1.22190983
56MP0003122_maternal_imprinting1.21727708
57MP0005501_abnormal_skin_physiology1.19214130
58MP0005646_abnormal_pituitary_gland1.17788678
59MP0003941_abnormal_skin_development1.17538922
60MP0001764_abnormal_homeostasis1.17392113
61MP0002638_abnormal_pupillary_reflex1.15833249
62MP0001145_abnormal_male_reproductive1.15273664
63MP0001919_abnormal_reproductive_system1.13287575
64MP0002751_abnormal_autonomic_nervous1.12337467
65MP0003763_abnormal_thymus_physiology1.11136243
66MP0000313_abnormal_cell_death1.10489222
67MP0003186_abnormal_redox_activity1.10312109
68MP0002234_abnormal_pharynx_morphology1.06806959
69MP0008789_abnormal_olfactory_epithelium1.05580857
70MP0002095_abnormal_skin_pigmentation1.05065857
71MP0001485_abnormal_pinna_reflex1.04393821
72MP0008260_abnormal_autophagy1.03838036
73MP0005330_cardiomyopathy1.02670637
74MP0001929_abnormal_gametogenesis1.00627564
75MP0003121_genomic_imprinting1.00511120
76MP0006276_abnormal_autonomic_nervous1.00335470
77MP0002111_abnormal_tail_morphology1.00205618
78MP0005451_abnormal_body_composition0.99423731
79MP0000350_abnormal_cell_proliferation0.98829290
80MP0008875_abnormal_xenobiotic_pharmacok0.98741422
81MP0004233_abnormal_muscle_weight0.97762283
82MP0000653_abnormal_sex_gland0.97565824
83MP0004185_abnormal_adipocyte_glucose0.97417553
84MP0001730_embryonic_growth_arrest0.95887937
85MP0005171_absent_coat_pigmentation0.95031865
86MP0005423_abnormal_somatic_nervous0.93531930
87MP0005360_urolithiasis0.92581551
88MP0003878_abnormal_ear_physiology0.92048732
89MP0005377_hearing/vestibular/ear_phenot0.92048732
90MP0001293_anophthalmia0.91929793
91MP0005332_abnormal_amino_acid0.89599061
92MP0002653_abnormal_ependyma_morphology0.88727206
93MP0000703_abnormal_thymus_morphology0.87975145
94MP0000358_abnormal_cell_content/0.87496337
95MP0000613_abnormal_salivary_gland0.87110674
96MP0001727_abnormal_embryo_implantation0.87042709
97MP0000678_abnormal_parathyroid_gland0.86577008
98MP0003937_abnormal_limbs/digits/tail_de0.86157029
99MP0002233_abnormal_nose_morphology0.85952190
100MP0002019_abnormal_tumor_incidence0.84654011
101MP0005380_embryogenesis_phenotype0.82442312
102MP0001672_abnormal_embryogenesis/_devel0.82442312
103MP0003646_muscle_fatigue0.80134240
104MP0001968_abnormal_touch/_nociception0.78826655
105MP0002876_abnormal_thyroid_physiology0.78103885
106MP0005394_taste/olfaction_phenotype0.76862216
107MP0005499_abnormal_olfactory_system0.76862216
108MP0002084_abnormal_developmental_patter0.75541522
109MP0002938_white_spotting0.75491154
110MP0008995_early_reproductive_senescence0.74453639
111MP0002396_abnormal_hematopoietic_system0.73825684
112MP0002557_abnormal_social/conspecific_i0.73519091
113MP0003806_abnormal_nucleotide_metabolis0.72761286
114MP0001853_heart_inflammation0.72725869
115MP0002080_prenatal_lethality0.72487531
116MP0002127_abnormal_cardiovascular_syste0.72445226
117MP0002163_abnormal_gland_morphology0.72398070
118MP0000858_altered_metastatic_potential0.72265261
119MP0001697_abnormal_embryo_size0.71763274
120MP0003698_abnormal_male_reproductive0.71655727
121MP0003861_abnormal_nervous_system0.71384502
122MP0001661_extended_life_span0.70696531
123MP0002722_abnormal_immune_system0.70452956
124MP0000049_abnormal_middle_ear0.70428079
125MP0005083_abnormal_biliary_tract0.69026954
126MP0002089_abnormal_postnatal_growth/wei0.68122188
127MP0000750_abnormal_muscle_regeneration0.68070849
128MP0002752_abnormal_somatic_nervous0.67234061
129MP0005623_abnormal_meninges_morphology0.66663002
130MP0006072_abnormal_retinal_apoptosis0.66301530
131MP0000681_abnormal_thyroid_gland0.66112699
132MP0000689_abnormal_spleen_morphology0.65289693
133MP0000003_abnormal_adipose_tissue0.65068004
134MP0009697_abnormal_copulation0.64908531
135MP0003942_abnormal_urinary_system0.63952369
136MP0000026_abnormal_inner_ear0.63275496
137MP0000631_abnormal_neuroendocrine_gland0.63181080
138MP0003011_delayed_dark_adaptation0.61534119
139MP0002085_abnormal_embryonic_tissue0.61089995
140MP0003567_abnormal_fetal_cardiomyocyte0.60638406
141MP0001186_pigmentation_phenotype0.59242612
142MP0000762_abnormal_tongue_morphology0.59026327
143MP0002398_abnormal_bone_marrow0.55845221
144MP0002735_abnormal_chemical_nociception0.55630054
145MP0001119_abnormal_female_reproductive0.54565504
146MP0002272_abnormal_nervous_system0.53937972

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.02571263
2Abnormality of cells of the erythroid lineage (HP:0012130)4.70429149
3Muscle abnormality related to mitochondrial dysfunction (HP:0003800)4.65464461
4Abnormal number of erythroid precursors (HP:0012131)4.54942124
5Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.38039235
6Progressive external ophthalmoplegia (HP:0000590)4.35436759
7Macrocytic anemia (HP:0001972)4.21078360
8Acute necrotizing encephalopathy (HP:0006965)4.20242583
9Mitochondrial inheritance (HP:0001427)4.19652545
10Hepatocellular necrosis (HP:0001404)4.07907882
11Ragged-red muscle fibers (HP:0003200)4.01259864
12Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.80945529
13Decreased activity of mitochondrial respiratory chain (HP:0008972)3.80945529
14Breast hypoplasia (HP:0003187)3.76301744
15Abnormal mitochondria in muscle tissue (HP:0008316)3.76000421
16Increased hepatocellular lipid droplets (HP:0006565)3.63213110
17Increased CSF lactate (HP:0002490)3.63101709
18Pallor (HP:0000980)3.60406487
19Hyperglycinemia (HP:0002154)3.49600175
20Cerebral hypomyelination (HP:0006808)3.48407199
21Hepatic necrosis (HP:0002605)3.43958571
22Increased serum lactate (HP:0002151)3.43452571
233-Methylglutaconic aciduria (HP:0003535)3.42533550
24Birth length less than 3rd percentile (HP:0003561)3.37846318
25Aplasia/Hypoplasia of the sacrum (HP:0008517)3.32550378
26Progressive macrocephaly (HP:0004481)3.25189563
27Acute encephalopathy (HP:0006846)3.17886201
28Renal Fanconi syndrome (HP:0001994)3.16241134
29Duplicated collecting system (HP:0000081)3.12692795
30Exercise intolerance (HP:0003546)3.06898498
31Lipid accumulation in hepatocytes (HP:0006561)3.05137196
32Chromosomal breakage induced by crosslinking agents (HP:0003221)2.96806774
33Microvesicular hepatic steatosis (HP:0001414)2.94584817
34Aplastic anemia (HP:0001915)2.86219037
35Exertional dyspnea (HP:0002875)2.85785887
36Increased intramyocellular lipid droplets (HP:0012240)2.79134000
37Chromsome breakage (HP:0040012)2.77619203
38Rough bone trabeculation (HP:0100670)2.77208427
39Type I transferrin isoform profile (HP:0003642)2.76052800
40Oral leukoplakia (HP:0002745)2.75732059
41Meckel diverticulum (HP:0002245)2.74669506
42Progressive muscle weakness (HP:0003323)2.74499295
43Abnormality of the preputium (HP:0100587)2.71844249
44Abnormality of the renal collecting system (HP:0004742)2.63631773
45Broad distal phalanx of finger (HP:0009836)2.63193507
46Optic disc pallor (HP:0000543)2.61428548
47Lactic acidosis (HP:0003128)2.60897003
48Absent thumb (HP:0009777)2.60817256
49Triphalangeal thumb (HP:0001199)2.60505640
50Abnormality of the ileum (HP:0001549)2.59472407
51Respiratory failure (HP:0002878)2.52953921
52Multiple enchondromatosis (HP:0005701)2.52514815
53Carpal bone hypoplasia (HP:0001498)2.49580738
54Opisthotonus (HP:0002179)2.40365748
55Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.40248264
56Abnormality of glycine metabolism (HP:0010895)2.38536084
57Abnormality of serine family amino acid metabolism (HP:0010894)2.38536084
58External ophthalmoplegia (HP:0000544)2.37861749
59Hypokinesia (HP:0002375)2.36820630
60Abnormality of the aortic arch (HP:0012303)2.36796571
61Pancytopenia (HP:0001876)2.33157251
62Absent radius (HP:0003974)2.32537445
63Esophageal atresia (HP:0002032)2.32040660
64Horseshoe kidney (HP:0000085)2.29756703
65Respiratory difficulties (HP:0002880)2.24643966
66Asplenia (HP:0001746)2.23751078
67Hyperglycinuria (HP:0003108)2.23447029
68Aplasia involving forearm bones (HP:0009822)2.18471036
69Absent forearm bone (HP:0003953)2.18471036
70Aplasia/Hypoplasia of the uvula (HP:0010293)2.18439465
71Death in infancy (HP:0001522)2.18381750
72Premature graying of hair (HP:0002216)2.17187636
73Increased muscle lipid content (HP:0009058)2.16660220
74Type 2 muscle fiber atrophy (HP:0003554)2.16199745
75Microretrognathia (HP:0000308)2.14918821
76Patellar aplasia (HP:0006443)2.14491066
77Muscle fiber atrophy (HP:0100295)2.14125328
78Aplasia/hypoplasia of the uterus (HP:0008684)2.12269107
79Testicular atrophy (HP:0000029)2.11355048
80Supernumerary spleens (HP:0009799)2.10997406
81Cerebral edema (HP:0002181)2.10802005
82Abnormality of chromosome stability (HP:0003220)2.10495693
83Delayed CNS myelination (HP:0002188)2.10298423
84Abnormal trabecular bone morphology (HP:0100671)2.08592619
85Cleft eyelid (HP:0000625)2.06063705
86Aplasia/Hypoplasia of the patella (HP:0006498)2.05593767
87Myokymia (HP:0002411)2.04847604
88Retinal dysplasia (HP:0007973)2.04455639
89Reduced antithrombin III activity (HP:0001976)2.02938281
90Methylmalonic aciduria (HP:0012120)2.01911348
91Bone marrow hypocellularity (HP:0005528)2.00990105
92Dicarboxylic aciduria (HP:0003215)2.00211634
93Abnormality of dicarboxylic acid metabolism (HP:0010995)2.00211634
94Trismus (HP:0000211)2.00202396
95Emotional lability (HP:0000712)1.98435861
96Aplasia/Hypoplasia of the spleen (HP:0010451)1.98183089
97Hypoplasia of the radius (HP:0002984)1.96882604
98Lethargy (HP:0001254)1.95720194
99Secondary amenorrhea (HP:0000869)1.95664959
100Megaloblastic anemia (HP:0001889)1.94725646
101Abnormality of renal resorption (HP:0011038)1.92965823
102Leukodystrophy (HP:0002415)1.92581177
103Absent rod-and cone-mediated responses on ERG (HP:0007688)1.91955993
104CNS hypomyelination (HP:0003429)1.90389273
105Increased serum pyruvate (HP:0003542)1.89360367
106Abnormality of glycolysis (HP:0004366)1.89360367
107Sparse eyelashes (HP:0000653)1.88752571
108Gout (HP:0001997)1.86921681
109Progressive microcephaly (HP:0000253)1.86676172
110Abnormal protein glycosylation (HP:0012346)1.85218284
111Abnormal glycosylation (HP:0012345)1.85218284
112Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.85218284
113Abnormal protein N-linked glycosylation (HP:0012347)1.85218284
114Unsteady gait (HP:0002317)1.84582533
115High anterior hairline (HP:0009890)1.83830989
116Aplasia/Hypoplasia involving the musculature (HP:0001460)1.83439982
117Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.82864470
118Granulocytopenia (HP:0001913)1.82754247
119Fasciculations (HP:0002380)1.82253035
120Abnormality of the anterior horn cell (HP:0006802)1.81156976
121Degeneration of anterior horn cells (HP:0002398)1.81156976
122Abnormality of secondary sexual hair (HP:0009888)1.78929996
123Abnormality of the axillary hair (HP:0100134)1.78929996
124Parakeratosis (HP:0001036)1.78695865
125Abnormality of alanine metabolism (HP:0010916)1.78470684
126Hyperalaninemia (HP:0003348)1.78470684
127Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.78470684
128Abnormality of the fetal cardiovascular system (HP:0010948)1.78382108
129Abnormal umbilical cord blood vessels (HP:0011403)1.78382108
130Single umbilical artery (HP:0001195)1.78382108
131CNS demyelination (HP:0007305)1.77644064
132Hyperammonemia (HP:0001987)1.77037800
133Abnormality of serum amino acid levels (HP:0003112)1.76109362
134Truncus arteriosus (HP:0001660)1.70397428
135Abnormality of the umbilical cord (HP:0010881)1.66992269
136Facial cleft (HP:0002006)1.66711579
137Rhabdomyolysis (HP:0003201)1.66423819
138Athetosis (HP:0002305)1.64702369
139Abnormal ventriculo-arterial connection (HP:0011563)1.60801833
140Transposition of the great arteries (HP:0001669)1.60801833
141Abnormal connection of the cardiac segments (HP:0011545)1.60801833
142Abnormality of magnesium homeostasis (HP:0004921)1.59409624
143Hypoplastic left heart (HP:0004383)1.58637143

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.44293161
2STK164.15348703
3VRK23.81534618
4IRAK33.64851367
5TLK13.62856497
6PLK43.24426384
7NME23.21234015
8EIF2AK13.01427295
9WEE12.82110288
10SRPK12.59297264
11TESK22.54664706
12MAP4K22.45034189
13MAP2K62.35550895
14IRAK42.34734789
15ZAK2.26329424
16IRAK22.25180512
17EIF2AK32.23516266
18VRK12.15915717
19SMG11.95617045
20IRAK11.85650113
21MKNK21.84139958
22PBK1.82149380
23NME11.69385451
24DYRK31.57440756
25TNIK1.57201043
26CDC71.54925103
27MKNK11.53701550
28CDK191.52163376
29NEK11.50463631
30TTK1.44183421
31CSNK1A1L1.43596722
32CSNK1G21.34064015
33MARK11.27493299
34CSNK1G11.26953026
35MAP2K71.20859618
36PLK11.19572029
37MAP3K51.19038642
38AURKA1.17415188
39PIM21.16114842
40BLK1.16025587
41DAPK11.15895993
42MAP3K111.14510469
43PDK21.12744535
44BRAF1.09829087
45ARAF1.09820167
46LIMK11.04685566
47TSSK61.04477590
48ACVR1B0.98609634
49KDR0.98072892
50DYRK20.97050121
51CLK10.95475181
52CASK0.94198606
53EEF2K0.92868608
54EIF2AK20.92056256
55EPHA20.91811636
56PRKCI0.90958053
57CDK70.89545559
58SIK20.85159068
59AURKB0.84742956
60RPS6KB20.84589760
61PAK40.79203652
62BCKDK0.79172368
63RPS6KA50.78822999
64MAPKAPK30.75895912
65BRSK20.75343138
66MST40.74264693
67TRIM280.73780576
68CHEK20.73289710
69ATR0.70048184
70PRKD20.68399714
71PNCK0.67804662
72LMTK20.67438148
73ABL20.66961993
74ICK0.66067765
75STK390.65400661
76PLK30.64591881
77TESK10.64279529
78PRKD30.61325035
79TAF10.61199926
80PAK10.60810540
81ADRBK20.60240842
82LRRK20.59706222
83CDK11A0.59476273
84CSNK2A20.57761843
85NLK0.56327952
86NUAK10.56174635
87CSNK2A10.56046562
88ILK0.56041665
89CDK140.55095832
90MUSK0.54334346
91EPHA40.53880578
92MAP3K80.53878077
93MAPK110.52264449
94CDK150.51437517
95CAMK2B0.49101516
96INSRR0.49054299
97CDK180.48974546
98TRIB30.48321229
99ERN10.46581718
100AKT20.45802963
101OXSR10.45399382
102RPS6KA40.44740889
103BRSK10.44215293
104YES10.44208431
105TEC0.42300328
106NEK20.42199595
107STK40.40979859
108CDK80.40950404
109FES0.38526806
110NEK60.38405689
111CSNK1G30.37240642
112CHEK10.37020961
113PINK10.36779870
114MAPKAPK50.35911443
115TXK0.35415599
116UHMK10.34641172
117GRK70.33817443
118BMPR1B0.33288113
119CAMK2G0.33278241
120STK38L0.31954295
121MINK10.31917264
122CSNK1A10.31818373
123CDK40.30581461
124CAMK2D0.30452464
125MAPK130.30140929
126GRK10.29988229
127CDK10.29741263
128CSNK1E0.27335536
129CCNB10.27330040
130DAPK30.26483598
131BCR0.25407432
132TAOK20.23826025
133ATM0.23756903
134CDK20.23250620
135SCYL20.23143319
136PRPF4B0.22990105
137IKBKB0.22881061
138WNK40.20404791
139ALK0.16246845
140PASK0.14860215

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.49022794
2RNA polymerase_Homo sapiens_hsa030204.22280487
3DNA replication_Homo sapiens_hsa030304.04905019
4Proteasome_Homo sapiens_hsa030503.94474082
5Mismatch repair_Homo sapiens_hsa034303.40859727
6Oxidative phosphorylation_Homo sapiens_hsa001903.19033403
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.99390744
8Spliceosome_Homo sapiens_hsa030402.93867395
9Homologous recombination_Homo sapiens_hsa034402.87372598
10Pyrimidine metabolism_Homo sapiens_hsa002402.84217990
11Parkinsons disease_Homo sapiens_hsa050122.79375269
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.55767470
13Fanconi anemia pathway_Homo sapiens_hsa034602.41433969
14Nucleotide excision repair_Homo sapiens_hsa034202.40813464
15Huntingtons disease_Homo sapiens_hsa050162.33572389
16Base excision repair_Homo sapiens_hsa034102.14139338
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.01954050
18Basal transcription factors_Homo sapiens_hsa030222.00117287
19RNA transport_Homo sapiens_hsa030131.98629689
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.94482495
21Alzheimers disease_Homo sapiens_hsa050101.89772600
22Protein export_Homo sapiens_hsa030601.82962046
23One carbon pool by folate_Homo sapiens_hsa006701.68921282
24Purine metabolism_Homo sapiens_hsa002301.66181102
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.65610860
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.62471751
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.59606089
28Non-homologous end-joining_Homo sapiens_hsa034501.50515844
29Cell cycle_Homo sapiens_hsa041101.46058978
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.43900679
31RNA degradation_Homo sapiens_hsa030181.41629039
32Pyruvate metabolism_Homo sapiens_hsa006201.31955044
33Folate biosynthesis_Homo sapiens_hsa007901.28400369
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.25222208
35Sulfur relay system_Homo sapiens_hsa041221.24203273
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.23950192
37Phenylalanine metabolism_Homo sapiens_hsa003601.20311190
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.19505543
39p53 signaling pathway_Homo sapiens_hsa041151.10702034
40Cardiac muscle contraction_Homo sapiens_hsa042601.10397672
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.99384754
42Epstein-Barr virus infection_Homo sapiens_hsa051690.98378384
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87861969
44Glutathione metabolism_Homo sapiens_hsa004800.84269017
45Phototransduction_Homo sapiens_hsa047440.82090116
46Systemic lupus erythematosus_Homo sapiens_hsa053220.81299297
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80688417
48Vitamin digestion and absorption_Homo sapiens_hsa049770.79051445
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79031383
50mRNA surveillance pathway_Homo sapiens_hsa030150.78536886
51Arachidonic acid metabolism_Homo sapiens_hsa005900.78297569
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.76899278
53Selenocompound metabolism_Homo sapiens_hsa004500.72192661
54Peroxisome_Homo sapiens_hsa041460.71189718
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67181126
56Metabolic pathways_Homo sapiens_hsa011000.67046400
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64435612
58Pentose phosphate pathway_Homo sapiens_hsa000300.64398247
59Vitamin B6 metabolism_Homo sapiens_hsa007500.58513917
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57795326
61Fatty acid metabolism_Homo sapiens_hsa012120.57051358
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56989170
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.55753246
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.55347793
65Fat digestion and absorption_Homo sapiens_hsa049750.53937720
66Sphingolipid metabolism_Homo sapiens_hsa006000.53562394
67Propanoate metabolism_Homo sapiens_hsa006400.52947418
68Linoleic acid metabolism_Homo sapiens_hsa005910.52832504
69Sulfur metabolism_Homo sapiens_hsa009200.52319733
70Primary immunodeficiency_Homo sapiens_hsa053400.52049327
71Arginine biosynthesis_Homo sapiens_hsa002200.51067777
72Other glycan degradation_Homo sapiens_hsa005110.51062487
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50918289
74Synaptic vesicle cycle_Homo sapiens_hsa047210.48435941
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45538868
76Ether lipid metabolism_Homo sapiens_hsa005650.42910229
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42350322
78beta-Alanine metabolism_Homo sapiens_hsa004100.41776332
79Oocyte meiosis_Homo sapiens_hsa041140.40195710
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39872037
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38829354
82Alcoholism_Homo sapiens_hsa050340.37952860
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36459708
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36126658
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.35277225
86Herpes simplex infection_Homo sapiens_hsa051680.34475388
87Arginine and proline metabolism_Homo sapiens_hsa003300.33497862
88Fatty acid elongation_Homo sapiens_hsa000620.32668036
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.32589174
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30569356
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29383303
92Regulation of autophagy_Homo sapiens_hsa041400.26936109
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.26668113
94Fatty acid degradation_Homo sapiens_hsa000710.24082747
95Butanoate metabolism_Homo sapiens_hsa006500.23649205
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.23614403
97Viral carcinogenesis_Homo sapiens_hsa052030.23388457
98Autoimmune thyroid disease_Homo sapiens_hsa053200.21950825
99Thyroid cancer_Homo sapiens_hsa052160.21163291
100Asthma_Homo sapiens_hsa053100.21066738
101Basal cell carcinoma_Homo sapiens_hsa052170.18407929
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.17786857
103Collecting duct acid secretion_Homo sapiens_hsa049660.16070193
104Primary bile acid biosynthesis_Homo sapiens_hsa001200.15005471
105N-Glycan biosynthesis_Homo sapiens_hsa005100.14686560
106Biosynthesis of amino acids_Homo sapiens_hsa012300.12854906
107Hippo signaling pathway_Homo sapiens_hsa043900.12466531
108Graft-versus-host disease_Homo sapiens_hsa053320.11673385
109Steroid hormone biosynthesis_Homo sapiens_hsa001400.10465296
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.10440856
111Vibrio cholerae infection_Homo sapiens_hsa051100.10428926
112Antigen processing and presentation_Homo sapiens_hsa046120.10193519
113HTLV-I infection_Homo sapiens_hsa051660.09954294
114Intestinal immune network for IgA production_Homo sapiens_hsa046720.09375327
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.06789738
116Fructose and mannose metabolism_Homo sapiens_hsa000510.06426193
117Hematopoietic cell lineage_Homo sapiens_hsa046400.05684226
118NF-kappa B signaling pathway_Homo sapiens_hsa040640.05597264
119Allograft rejection_Homo sapiens_hsa053300.05388529
120Shigellosis_Homo sapiens_hsa051310.04372828
121RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.04107032
122Serotonergic synapse_Homo sapiens_hsa047260.02947239
123Measles_Homo sapiens_hsa051620.02895356
124Apoptosis_Homo sapiens_hsa042100.02142641
125Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.01945118
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.01754041
127Carbon metabolism_Homo sapiens_hsa012000.01193601
128Nicotine addiction_Homo sapiens_hsa05033-0.0562148
129Galactose metabolism_Homo sapiens_hsa00052-0.0537288
130Wnt signaling pathway_Homo sapiens_hsa04310-0.0464691
131Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533-0.0458915
132Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.0306588
133Steroid biosynthesis_Homo sapiens_hsa00100-0.0304440
134Tyrosine metabolism_Homo sapiens_hsa00350-0.0022463

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