MRPS27

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that may be a functional partner of the death associated protein 3 (DAP3). Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nucleobase biosynthetic process (GO:0046112)4.99906028
2purine nucleobase biosynthetic process (GO:0009113)4.87966502
3nuclear pore complex assembly (GO:0051292)4.81163703
4DNA strand elongation involved in DNA replication (GO:0006271)4.50522229
5nuclear pore organization (GO:0006999)4.41454990
6DNA strand elongation (GO:0022616)4.30133670
7formation of translation preinitiation complex (GO:0001731)4.19343644
8regulation of translational fidelity (GO:0006450)4.14618151
9telomere maintenance via semi-conservative replication (GO:0032201)4.14059742
10mitotic metaphase plate congression (GO:0007080)4.09412429
11IMP biosynthetic process (GO:0006188)4.08217793
12DNA replication checkpoint (GO:0000076)4.05427793
13proteasome assembly (GO:0043248)3.96140579
14DNA replication initiation (GO:0006270)3.92482766
15double-strand break repair via nonhomologous end joining (GO:0006303)3.83513675
16non-recombinational repair (GO:0000726)3.83513675
17maturation of SSU-rRNA (GO:0030490)3.83273339
18DNA unwinding involved in DNA replication (GO:0006268)3.80842416
19L-serine metabolic process (GO:0006563)3.78106932
20folic acid-containing compound biosynthetic process (GO:0009396)3.76160248
21sister chromatid segregation (GO:0000819)3.71554963
22protein localization to kinetochore (GO:0034501)3.70726123
23ribosomal small subunit assembly (GO:0000028)3.69587093
24oxidative phosphorylation (GO:0006119)3.69032022
25mitotic chromosome condensation (GO:0007076)3.65151653
26cullin deneddylation (GO:0010388)3.64089292
27telomere maintenance via recombination (GO:0000722)3.62956267
28negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.62554277
29ribosome biogenesis (GO:0042254)3.61273740
30establishment of viral latency (GO:0019043)3.61100156
31IMP metabolic process (GO:0046040)3.60143438
32CENP-A containing nucleosome assembly (GO:0034080)3.58987026
33positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.55970588
34anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.55721739
35metaphase plate congression (GO:0051310)3.54970244
36regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.53679779
37mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.53455996
38protein deneddylation (GO:0000338)3.53417194
39DNA deamination (GO:0045006)3.53057393
40chromatin remodeling at centromere (GO:0031055)3.51806657
41pore complex assembly (GO:0046931)3.49323445
42rRNA modification (GO:0000154)3.48072716
43mitotic nuclear envelope disassembly (GO:0007077)3.44624649
44spliceosomal snRNP assembly (GO:0000387)3.42265804
45mitotic recombination (GO:0006312)3.39965779
46positive regulation of chromosome segregation (GO:0051984)3.39065614
47L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.36466569
48regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.36351354
49tricarboxylic acid cycle (GO:0006099)3.34538833
50DNA ligation (GO:0006266)3.33429590
51telomere maintenance via telomere lengthening (GO:0010833)3.32328828
52negative regulation of ligase activity (GO:0051352)3.30475608
53negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.30475608
54DNA replication-dependent nucleosome assembly (GO:0006335)3.27790236
55DNA replication-dependent nucleosome organization (GO:0034723)3.27790236
56pseudouridine synthesis (GO:0001522)3.27200363
57transcription-coupled nucleotide-excision repair (GO:0006283)3.27108741
58ribosome assembly (GO:0042255)3.26607448
59ribonucleoprotein complex biogenesis (GO:0022613)3.26167964
60DNA topological change (GO:0006265)3.23251621
61regulation of cellular amino acid metabolic process (GO:0006521)3.21303685
62nucleotide-excision repair, DNA gap filling (GO:0006297)3.20608051
63folic acid metabolic process (GO:0046655)3.19811718
64establishment of chromosome localization (GO:0051303)3.19687199
65ribosomal large subunit biogenesis (GO:0042273)3.18950938
66spindle checkpoint (GO:0031577)3.18778788
67ATP synthesis coupled proton transport (GO:0015986)3.17115258
68energy coupled proton transport, down electrochemical gradient (GO:0015985)3.17115258
69DNA replication-independent nucleosome organization (GO:0034724)3.16128408
70DNA replication-independent nucleosome assembly (GO:0006336)3.16128408
71establishment of integrated proviral latency (GO:0075713)3.16036623
72mitotic sister chromatid cohesion (GO:0007064)3.15228061
73rRNA processing (GO:0006364)3.14610901
74viral mRNA export from host cell nucleus (GO:0046784)3.14120599
75regulation of sister chromatid cohesion (GO:0007063)3.14013321
76regulation of chromosome segregation (GO:0051983)3.13544569
77mitotic spindle checkpoint (GO:0071174)3.13065822
78DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.12737496
79nuclear envelope disassembly (GO:0051081)3.12638822
80membrane disassembly (GO:0030397)3.12638822
817-methylguanosine mRNA capping (GO:0006370)3.12612982
82mitochondrial RNA metabolic process (GO:0000959)3.11859989
83negative regulation of chromosome segregation (GO:0051985)3.11616365
84positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.10172064
85regulation of centriole replication (GO:0046599)3.07816797
86amino acid salvage (GO:0043102)3.06922606
87L-methionine salvage (GO:0071267)3.06922606
88L-methionine biosynthetic process (GO:0071265)3.06922606
897-methylguanosine RNA capping (GO:0009452)3.06878282
90RNA capping (GO:0036260)3.06878282
91signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.06687660
92intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.06687660
93negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.06616838
94negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.06616838
95negative regulation of mitotic sister chromatid segregation (GO:0033048)3.06616838
96negative regulation of mitotic sister chromatid separation (GO:2000816)3.06616838
97negative regulation of sister chromatid segregation (GO:0033046)3.06616838
98signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.05258644
99signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.05258644
100signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.05258644
101histone exchange (GO:0043486)3.05253761
102glycine metabolic process (GO:0006544)3.04917880
103regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.03650441
104regulation of mitotic metaphase/anaphase transition (GO:0030071)3.03650441
105signal transduction involved in DNA damage checkpoint (GO:0072422)3.02088579
106signal transduction involved in DNA integrity checkpoint (GO:0072401)3.02088579
107rRNA metabolic process (GO:0016072)3.01418317
108kinetochore organization (GO:0051383)3.00704616
109regulation of mitochondrial translation (GO:0070129)2.99885539
110deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.99131994
111cell cycle G1/S phase transition (GO:0044843)2.99098695
112G1/S transition of mitotic cell cycle (GO:0000082)2.99098695
113somatic hypermutation of immunoglobulin genes (GO:0016446)2.98987311
114somatic diversification of immune receptors via somatic mutation (GO:0002566)2.98987311
115protein localization to chromosome, centromeric region (GO:0071459)2.98866727
116mitotic sister chromatid segregation (GO:0000070)2.98833513
117nucleobase-containing small molecule interconversion (GO:0015949)2.98688839
118tRNA aminoacylation for protein translation (GO:0006418)2.98187633
119kinetochore assembly (GO:0051382)2.97831546
120signal transduction involved in cell cycle checkpoint (GO:0072395)2.97083703
121DNA duplex unwinding (GO:0032508)2.96685281
122tetrahydrofolate metabolic process (GO:0046653)2.96244972
123rRNA methylation (GO:0031167)2.96085766
124regulation of mitotic sister chromatid segregation (GO:0033047)2.95505744
125regulation of sister chromatid segregation (GO:0033045)2.95505744
126regulation of mitotic sister chromatid separation (GO:0010965)2.95505744
127tRNA aminoacylation (GO:0043039)2.95463817
128amino acid activation (GO:0043038)2.95463817
129maturation of 5.8S rRNA (GO:0000460)2.94492609
130cellular component biogenesis (GO:0044085)2.93820416
131mitotic spindle assembly checkpoint (GO:0007094)2.93551039
132positive regulation of ligase activity (GO:0051351)2.93076230
133attachment of spindle microtubules to kinetochore (GO:0008608)2.92297506
134spliceosomal complex assembly (GO:0000245)2.92290664
135DNA geometric change (GO:0032392)2.91832979
136protein complex localization (GO:0031503)2.89512791
137regulation of spindle organization (GO:0090224)2.89235627
138spindle assembly checkpoint (GO:0071173)2.88333925
139base-excision repair (GO:0006284)2.87989582
140regulation of mitotic spindle organization (GO:0060236)2.87688063
141pteridine-containing compound biosynthetic process (GO:0042559)2.86498486
142positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.84620929

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.71916108
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.42106248
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.07667493
4* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.04142583
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.54698373
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.42424601
7* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.14751413
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.14189657
9* CREB1_15753290_ChIP-ChIP_HEK293T_Human3.14059290
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.13767047
11GABP_17652178_ChIP-ChIP_JURKAT_Human3.11777572
12ETS1_20019798_ChIP-Seq_JURKAT_Human3.11190920
13FOXM1_23109430_ChIP-Seq_U2OS_Human3.03042773
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.98595225
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.97626797
16* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.93107197
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.85876535
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.57012039
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.44079110
20XRN2_22483619_ChIP-Seq_HELA_Human2.37075880
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.36243826
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.35164745
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.32811470
24E2F1_18555785_ChIP-Seq_MESCs_Mouse2.30607902
25VDR_23849224_ChIP-Seq_CD4+_Human2.19405470
26DCP1A_22483619_ChIP-Seq_HELA_Human2.15169835
27* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.14076136
28FOXP3_21729870_ChIP-Seq_TREG_Human2.11382041
29* SRF_21415370_ChIP-Seq_HL-1_Mouse2.06688730
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02917561
31AR_21909140_ChIP-Seq_LNCAP_Human1.99015151
32GABP_19822575_ChIP-Seq_HepG2_Human1.98953846
33* YY1_21170310_ChIP-Seq_MESCs_Mouse1.95924000
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.92049392
35* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.90625244
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.88343591
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.87466145
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.84470904
39* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.83221627
40MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.80414173
41* TTF2_22483619_ChIP-Seq_HELA_Human1.80127339
42* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79324157
43* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.77260854
44SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.65786564
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.64778747
46ZFX_18555785_ChIP-Seq_MESCs_Mouse1.62921285
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61954965
48E2F1_21310950_ChIP-Seq_MCF-7_Human1.57267745
49CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.53284149
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.52778653
51CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.50317603
52CIITA_25753668_ChIP-Seq_RAJI_Human1.48901097
53ELK1_19687146_ChIP-ChIP_HELA_Human1.48623284
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.46922957
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45715492
56POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.45041873
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43909309
58ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.43165249
59* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41620477
60PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.39080083
61* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.38902539
62PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.38169193
63CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.38082454
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.36701356
65STAT3_1855785_ChIP-Seq_MESCs_Mouse1.32752955
66* KDM5A_27292631_Chip-Seq_BREAST_Human1.32047470
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30955292
68CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.24728097
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23679716
70* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.19601060
71HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.18216891
72ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17549679
73ZNF263_19887448_ChIP-Seq_K562_Human1.16399084
74SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10025413
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07116222
76MYC_18940864_ChIP-ChIP_HL60_Human1.06551193
77KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05941761
78E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05919389
79* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.05451996
80NANOG_16153702_ChIP-ChIP_HESCs_Human1.04398183
81ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.02315441
82MYC_22102868_ChIP-Seq_BL_Human1.02194086
83ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00049011
84KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97300147
85TFEB_21752829_ChIP-Seq_HELA_Human0.97126621
86ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94173306
87SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.92228713
88DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91810029
89CHD1_26751641_Chip-Seq_LNCaP_Human0.90872212
90OCT4_18692474_ChIP-Seq_MEFs_Mouse0.90258447
91HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.89691123
92SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.89622672
93NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.89612418
94SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89156309
95CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88052932
96NOTCH1_21737748_ChIP-Seq_TLL_Human0.88007693
97* SOX2_16153702_ChIP-ChIP_HESCs_Human0.87789033
98SOX2_18692474_ChIP-Seq_MEFs_Mouse0.87557253
99DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.86156138
100KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.86114588
101TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.85998842
102CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.83461793
103ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.82862200
104ELK1_22589737_ChIP-Seq_MCF10A_Human0.82298228
105SOX17_20123909_ChIP-Seq_XEN_Mouse0.82038058
106NANOG_21062744_ChIP-ChIP_HESCs_Human0.80664208
107CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.80551176
108GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.80347871
109TBX5_21415370_ChIP-Seq_HL-1_Mouse0.80044379
110NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.79964100
111SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.79670580
112CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.78628153
113HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.76282642
114ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.75529517
115GATA4_21415370_ChIP-Seq_HL-1_Mouse0.73606410

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.87153463
2MP0003806_abnormal_nucleotide_metabolis4.75576603
3MP0004957_abnormal_blastocyst_morpholog4.25904341
4MP0010094_abnormal_chromosome_stability4.12759364
5MP0003111_abnormal_nucleus_morphology3.78444225
6MP0003077_abnormal_cell_cycle3.66372680
7MP0008058_abnormal_DNA_repair3.40821149
8MP0008057_abnormal_DNA_replication3.18300821
9MP0003123_paternal_imprinting2.96429357
10MP0006036_abnormal_mitochondrial_physio2.71016093
11MP0008932_abnormal_embryonic_tissue2.54281739
12MP0008007_abnormal_cellular_replicative2.40183096
13MP0003941_abnormal_skin_development2.36966782
14MP0001730_embryonic_growth_arrest2.23381531
15MP0002139_abnormal_hepatobiliary_system2.22343406
16MP0005085_abnormal_gallbladder_physiolo2.18185037
17MP0002396_abnormal_hematopoietic_system2.16082028
18MP0008877_abnormal_DNA_methylation2.13964493
19MP0006035_abnormal_mitochondrial_morpho2.07278233
20MP0005365_abnormal_bile_salt1.98223291
21MP0003718_maternal_effect1.96108066
22MP0005360_urolithiasis1.95421263
23MP0001764_abnormal_homeostasis1.92620381
24MP0001661_extended_life_span1.80425242
25MP0009697_abnormal_copulation1.73767920
26MP0003186_abnormal_redox_activity1.70808542
27MP0000350_abnormal_cell_proliferation1.70371167
28MP0005266_abnormal_metabolism1.64620733
29MP0001293_anophthalmia1.62276247
30MP0001697_abnormal_embryo_size1.61590737
31MP0001672_abnormal_embryogenesis/_devel1.59360898
32MP0005380_embryogenesis_phenotype1.59360898
33MP0003221_abnormal_cardiomyocyte_apopto1.56563630
34MP0004133_heterotaxia1.55676713
35MP0004084_abnormal_cardiac_muscle1.50760812
36MP0002080_prenatal_lethality1.50644484
37MP0003984_embryonic_growth_retardation1.48403238
38MP0002132_abnormal_respiratory_system1.48363450
39MP0002088_abnormal_embryonic_growth/wei1.43847418
40MP0008875_abnormal_xenobiotic_pharmacok1.42056914
41MP0003646_muscle_fatigue1.40100668
42MP0003786_premature_aging1.38000113
43MP0002837_dystrophic_cardiac_calcinosis1.35938579
44MP0002269_muscular_atrophy1.34502671
45MP0003937_abnormal_limbs/digits/tail_de1.30995153
46MP0000358_abnormal_cell_content/1.30913751
47MP0006054_spinal_hemorrhage1.30108101
48MP0003567_abnormal_fetal_cardiomyocyte1.29383435
49MP0000537_abnormal_urethra_morphology1.24474636
50MP0003121_genomic_imprinting1.23686944
51MP0001529_abnormal_vocalization1.22908457
52MP0002697_abnormal_eye_size1.22056850
53MP0005330_cardiomyopathy1.19901866
54MP0010352_gastrointestinal_tract_polyps1.19637021
55MP0002009_preneoplasia1.18798305
56MP0000749_muscle_degeneration1.18068414
57MP0000313_abnormal_cell_death1.16529981
58MP0000566_synostosis1.15852934
59MP0002938_white_spotting1.14450483
60MP0004197_abnormal_fetal_growth/weight/1.12867009
61MP0002085_abnormal_embryonic_tissue1.12294046
62MP0010234_abnormal_vibrissa_follicle1.09797842
63MP0004147_increased_porphyrin_level1.09345393
64MP0005332_abnormal_amino_acid1.08407256
65MP0009840_abnormal_foam_cell1.07701667
66MP0002019_abnormal_tumor_incidence1.04181061
67MP0005501_abnormal_skin_physiology1.02715282
68MP0005376_homeostasis/metabolism_phenot1.02709339
69MP0002086_abnormal_extraembryonic_tissu1.02680273
70MP0001286_abnormal_eye_development1.01161969
71MP0002084_abnormal_developmental_patter1.00859755
72MP0002877_abnormal_melanocyte_morpholog1.00681684
73MP0002127_abnormal_cardiovascular_syste0.99543952
74MP0005319_abnormal_enzyme/_coenzyme0.98974591
75MP0004185_abnormal_adipocyte_glucose0.98827830
76MP0004233_abnormal_muscle_weight0.98584202
77MP0004215_abnormal_myocardial_fiber0.97966349
78MP0009053_abnormal_anal_canal0.97918701
79MP0003890_abnormal_embryonic-extraembry0.97375952
80MP0010307_abnormal_tumor_latency0.94842690
81MP0001346_abnormal_lacrimal_gland0.94133475
82MP0005083_abnormal_biliary_tract0.93675097
83MP0009703_decreased_birth_body0.92979131
84MP0002160_abnormal_reproductive_system0.91929088
85MP0009672_abnormal_birth_weight0.91128492
86MP0003119_abnormal_digestive_system0.87921216
87MP0001299_abnormal_eye_distance/0.87503030
88MP0005075_abnormal_melanosome_morpholog0.85986934
89MP0000490_abnormal_crypts_of0.85856747
90MP0000751_myopathy0.85212387
91MP0010030_abnormal_orbit_morphology0.84472230
92MP0003656_abnormal_erythrocyte_physiolo0.83672502
93MP0002092_abnormal_eye_morphology0.82503163
94MP0009379_abnormal_foot_pigmentation0.82348612
95MP0000598_abnormal_liver_morphology0.81852062
96MP0002210_abnormal_sex_determination0.81090824
97MP0003385_abnormal_body_wall0.80936733
98MP0004036_abnormal_muscle_relaxation0.79010823
99MP0002653_abnormal_ependyma_morphology0.78928722
100MP0000428_abnormal_craniofacial_morphol0.78139187
101MP0002234_abnormal_pharynx_morphology0.77365846
102MP0003950_abnormal_plasma_membrane0.77302414
103MP0002233_abnormal_nose_morphology0.77065269
104MP0003315_abnormal_perineum_morphology0.76989594
105MP0010329_abnormal_lipoprotein_level0.75561726
106MP0008789_abnormal_olfactory_epithelium0.75138293
107MP0001145_abnormal_male_reproductive0.74672624
108MP0002111_abnormal_tail_morphology0.73614996
109MP0005623_abnormal_meninges_morphology0.71271782
110MP0006072_abnormal_retinal_apoptosis0.69401838
111MP0002796_impaired_skin_barrier0.68699076
112MP0000747_muscle_weakness0.68605659
113MP0009333_abnormal_splenocyte_physiolog0.68525313
114MP0005389_reproductive_system_phenotype0.68337530
115MP0010630_abnormal_cardiac_muscle0.67857815
116MP0000653_abnormal_sex_gland0.67131669
117MP0000750_abnormal_muscle_regeneration0.65941055
118MP0004087_abnormal_muscle_fiber0.65871865
119MP0000609_abnormal_liver_physiology0.64219675
120MP0001119_abnormal_female_reproductive0.64112251
121MP0005451_abnormal_body_composition0.63995992
122MP0003755_abnormal_palate_morphology0.63417448
123MP0001915_intracranial_hemorrhage0.63034535
124MP0002332_abnormal_exercise_endurance0.62825679
125MP0001544_abnormal_cardiovascular_syste0.61996992
126MP0005385_cardiovascular_system_phenoty0.61996992
127MP0005384_cellular_phenotype0.60355853
128MP0005408_hypopigmentation0.60122244
129MP0001881_abnormal_mammary_gland0.60062751
130MP0000579_abnormal_nail_morphology0.59636947
131MP0003115_abnormal_respiratory_system0.59590264
132MP0000762_abnormal_tongue_morphology0.58472437
133MP0000372_irregular_coat_pigmentation0.58060315
134MP0002163_abnormal_gland_morphology0.57830917
135MP0008775_abnormal_heart_ventricle0.56917913
136MP0005584_abnormal_enzyme/coenzyme_acti0.56312494
137MP0006292_abnormal_olfactory_placode0.55707675
138MP0006138_congestive_heart_failure0.54910111
139MP0001929_abnormal_gametogenesis0.54882016
140MP0000266_abnormal_heart_morphology0.54870876

Predicted human phenotypes

RankGene SetZ-score
1Increased serum pyruvate (HP:0003542)4.63758534
2Abnormality of glycolysis (HP:0004366)4.63758534
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.25945599
4Chromsome breakage (HP:0040012)4.21804442
5Hepatic necrosis (HP:0002605)4.19612269
6Hepatocellular necrosis (HP:0001404)4.11719509
7Increased CSF lactate (HP:0002490)3.78786289
8Birth length less than 3rd percentile (HP:0003561)3.77304058
9Acute necrotizing encephalopathy (HP:0006965)3.62261028
10Abnormal mitochondria in muscle tissue (HP:0008316)3.62004288
11Increased serum lactate (HP:0002151)3.59784151
12Oral leukoplakia (HP:0002745)3.58881278
13Mitochondrial inheritance (HP:0001427)3.54796888
14Cerebral hypomyelination (HP:0006808)3.53883199
15Acute encephalopathy (HP:0006846)3.43487687
16Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.19043739
17Decreased activity of mitochondrial respiratory chain (HP:0008972)3.19043739
18Cerebral edema (HP:0002181)3.07213168
19Hypobetalipoproteinemia (HP:0003563)3.06962307
20Lactic acidosis (HP:0003128)3.04848290
21Abnormality of the anterior horn cell (HP:0006802)2.99922204
22Degeneration of anterior horn cells (HP:0002398)2.99922204
23Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.96680451
24Abnormality of alanine metabolism (HP:0010916)2.96680451
25Hyperalaninemia (HP:0003348)2.96680451
26Aplastic anemia (HP:0001915)2.89654302
27Nephroblastoma (Wilms tumor) (HP:0002667)2.86296474
28Progressive macrocephaly (HP:0004481)2.85996922
29Ragged-red muscle fibers (HP:0003200)2.85665013
30Abnormality of the preputium (HP:0100587)2.84541820
31CNS demyelination (HP:0007305)2.84182670
32Meckel diverticulum (HP:0002245)2.83423963
33Abnormality of chromosome stability (HP:0003220)2.80580686
34Lipid accumulation in hepatocytes (HP:0006561)2.75766650
35Abnormality of the ileum (HP:0001549)2.71424404
36Breast hypoplasia (HP:0003187)2.69936333
37Exercise intolerance (HP:0003546)2.69554460
38Colon cancer (HP:0003003)2.69107808
39Abnormality of pyrimidine metabolism (HP:0004353)2.67507814
40Multiple enchondromatosis (HP:0005701)2.66110264
41Embryonal renal neoplasm (HP:0011794)2.64357743
42Renal cortical cysts (HP:0000803)2.62835582
43Respiratory failure (HP:0002878)2.61611268
44Agnosia (HP:0010524)2.61504026
45Rough bone trabeculation (HP:0100670)2.59631110
46Aplasia/Hypoplasia of the uvula (HP:0010293)2.58067570
47Lethargy (HP:0001254)2.56248462
48Abnormality of cells of the erythroid lineage (HP:0012130)2.55619191
49Abnormal number of erythroid precursors (HP:0012131)2.54474112
50Rhabdomyolysis (HP:0003201)2.53197968
51Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.50843790
52Increased nuchal translucency (HP:0010880)2.48730652
53Increased hepatocellular lipid droplets (HP:0006565)2.48622387
54Emotional lability (HP:0000712)2.46928938
55Hyperammonemia (HP:0001987)2.44561186
56Microvesicular hepatic steatosis (HP:0001414)2.43471421
57Dicarboxylic aciduria (HP:0003215)2.42488506
58Abnormality of dicarboxylic acid metabolism (HP:0010995)2.42488506
59Microretrognathia (HP:0000308)2.42216150
60Nausea (HP:0002018)2.36306826
61Abnormality of fatty-acid metabolism (HP:0004359)2.35828161
62Increased muscle lipid content (HP:0009058)2.33719909
63Myelodysplasia (HP:0002863)2.32934456
64Reticulocytopenia (HP:0001896)2.32376381
65Duodenal stenosis (HP:0100867)2.30333166
66Small intestinal stenosis (HP:0012848)2.30333166
67Hyperglycinuria (HP:0003108)2.30308431
68Increased intramyocellular lipid droplets (HP:0012240)2.28997329
69Duplicated collecting system (HP:0000081)2.28738409
70Neoplasm of the adrenal cortex (HP:0100641)2.27392978
71Abnormality of serum amino acid levels (HP:0003112)2.27335976
72Hyperglycinemia (HP:0002154)2.25765227
73Type I transferrin isoform profile (HP:0003642)2.25058986
74Progressive external ophthalmoplegia (HP:0000590)2.23438573
75Respiratory difficulties (HP:0002880)2.22670718
76Cortical dysplasia (HP:0002539)2.21530213
77Neoplasm of the adrenal gland (HP:0100631)2.20004449
78Abnormality of the labia minora (HP:0012880)2.17552894
79Megaloblastic anemia (HP:0001889)2.16919572
80Pancreatic islet-cell hyperplasia (HP:0004510)2.16554418
81Abnormal lung lobation (HP:0002101)2.16286943
82Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.15915682
833-Methylglutaconic aciduria (HP:0003535)2.15905966
84Abnormality of monocarboxylic acid metabolism (HP:0010996)2.15308423
85Palpitations (HP:0001962)2.14595267
86Generalized aminoaciduria (HP:0002909)2.14531716
87Reduced antithrombin III activity (HP:0001976)2.14188083
88Selective tooth agenesis (HP:0001592)2.13661769
89Ependymoma (HP:0002888)2.12347759
90Premature ovarian failure (HP:0008209)2.11107695
91Exercise-induced muscle cramps (HP:0003710)2.08228646
92Abnormality of methionine metabolism (HP:0010901)2.07600229
93Carpal bone hypoplasia (HP:0001498)2.05099756
94CNS hypomyelination (HP:0003429)2.04763033
95Abnormal gallbladder physiology (HP:0012438)2.02810891
96Cholecystitis (HP:0001082)2.02810891
97Abnormality of serine family amino acid metabolism (HP:0010894)2.02509100
98Abnormality of glycine metabolism (HP:0010895)2.02509100
99Unsteady gait (HP:0002317)2.01155821
100Gliosis (HP:0002171)2.00746064
101Abnormality of the heme biosynthetic pathway (HP:0010472)1.99626401
102Abnormality of the duodenum (HP:0002246)1.99063356
103Macrocytic anemia (HP:0001972)1.99026247
104Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.98244621
105Abnormal protein N-linked glycosylation (HP:0012347)1.98244621
106Abnormal protein glycosylation (HP:0012346)1.98244621
107Abnormal glycosylation (HP:0012345)1.98244621
108Horseshoe kidney (HP:0000085)1.98066777
109Sloping forehead (HP:0000340)1.97442749
110Medulloblastoma (HP:0002885)1.96288787
111Hypoplasia of the capital femoral epiphysis (HP:0003090)1.95279160
112Adenoma sebaceum (HP:0009720)1.95200953
113Angiofibromas (HP:0010615)1.95200953
114Patellar aplasia (HP:0006443)1.94898170
115Postnatal microcephaly (HP:0005484)1.94160483
116Hypoglycemic coma (HP:0001325)1.93071798
11711 pairs of ribs (HP:0000878)1.92607816
118Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.91860715
119Myoglobinuria (HP:0002913)1.91081773
120Premature graying of hair (HP:0002216)1.90232460
121Intrahepatic cholestasis (HP:0001406)1.89811016
122Abnormality of aromatic amino acid family metabolism (HP:0004338)1.88996827
123Cellular immunodeficiency (HP:0005374)1.88965691
124Hyperinsulinemic hypoglycemia (HP:0000825)1.87044513
125Progressive muscle weakness (HP:0003323)1.86585011
126Secondary amenorrhea (HP:0000869)1.86447658
127Rhabdomyosarcoma (HP:0002859)1.85272635
128Posterior subcapsular cataract (HP:0007787)1.85131835
129Female pseudohermaphroditism (HP:0010458)1.83802758
130Absent radius (HP:0003974)1.82615803
131Pancytopenia (HP:0001876)1.81905772
132Abnormality of the renal collecting system (HP:0004742)1.81620626
133Hypoplastic pelvis (HP:0008839)1.80886941
134Neoplasm of the colon (HP:0100273)1.80824429
135Brushfield spots (HP:0001088)1.80352706
136Tongue fasciculations (HP:0001308)1.80077832
137Squamous cell carcinoma (HP:0002860)1.77351485
138Microglossia (HP:0000171)1.77314101
139Abnormality of aspartate family amino acid metabolism (HP:0010899)1.77102856
140Abnormality of the carotid arteries (HP:0005344)1.76787519
141Glioma (HP:0009733)1.76596475
142Cafe-au-lait spot (HP:0000957)1.74883529
143Abnormality of the astrocytes (HP:0100707)1.74781220
144Astrocytoma (HP:0009592)1.74781220
145Abnormality of sulfur amino acid metabolism (HP:0004339)1.70613954
146Spastic diplegia (HP:0001264)1.70381162
147Facial cleft (HP:0002006)1.70207400
148Aplasia/Hypoplasia of the sacrum (HP:0008517)1.70091313

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.01764079
2WEE14.12176047
3EIF2AK13.67332902
4NEK13.61326257
5VRK23.50268381
6TSSK63.38004259
7CDC73.25198570
8STK162.79942833
9BCKDK2.61022029
10PASK2.56160984
11VRK12.25161713
12TAF12.24187525
13CCNB12.14296936
14SRPK12.10749558
15BRSK22.05218424
16EIF2AK31.99081980
17SMG11.95754644
18PLK41.95248605
19PLK11.92547119
20TTK1.91578590
21PLK31.89786715
22NEK21.80000663
23PDK31.77403687
24PDK41.77403687
25ACVR1B1.76254348
26EEF2K1.65800093
27MST41.59279344
28PDK21.58645006
29BRSK11.45494467
30TRIM281.41925694
31MKNK11.37498071
32AURKB1.34617620
33TGFBR11.33353476
34FLT31.33063698
35NME21.32222775
36BRAF1.29779363
37CDK71.24948657
38TESK21.23452302
39ATR1.20605914
40AURKA1.19208941
41MYLK1.17435154
42ZAK1.17060762
43TLK11.05752160
44PAK41.03785234
45MAP3K81.02083744
46MAP2K30.98290442
47OBSCN0.97809701
48PINK10.97639701
49KDR0.97065212
50CDK80.95518299
51CDK40.95177017
52NUAK10.94949965
53RPS6KB20.89660739
54PKN20.89541380
55MAP4K20.88627660
56CHEK20.88510878
57EPHA20.87815606
58CLK10.86572959
59DAPK10.86388585
60PIM20.85974712
61STK38L0.85380644
62CHEK10.85154501
63ARAF0.84228959
64AKT30.80965017
65MAPKAPK50.80150938
66MKNK20.79031989
67DYRK30.78550633
68NME10.77071756
69CSNK2A10.75449618
70CSNK2A20.74505404
71CDK60.72669908
72EIF2AK20.71914641
73STK40.70859036
74CSNK1G10.69986899
75PNCK0.69688913
76SCYL20.66174030
77MST1R0.63706002
78LATS20.63564965
79MAP3K110.63025853
80CSNK1G30.59713390
81CDK20.58757822
82RPS6KA40.54737064
83PAK10.54074564
84MAP3K30.53595053
85CSNK1A1L0.53510842
86RPS6KC10.52550889
87RPS6KL10.52550889
88BCR0.50916733
89PRKD30.50367725
90ATM0.50000170
91ILK0.48875294
92RPS6KA60.48187153
93MAP2K60.46120779
94TESK10.45615272
95PRKDC0.44187200
96BRD40.43753736
97PRKCI0.43499448
98STK100.43392564
99CDK10.42505121
100TAOK20.39429261
101STK30.38489901
102CSNK1G20.36937328
103BMPR1B0.36505038
104SIK30.34503192
105FGFR10.32768260
106RPS6KB10.31172219
107PIM10.29597499
108ERBB30.29178159
109MAP3K120.29044481
110ABL20.28931236
111CSNK1E0.28631497
112CDK90.27976183
113NEK90.27935660
114CDK150.27475115
115PAK20.27436655
116AKT20.26852780
117CDK11A0.26595994
118CDK140.26207496
119PBK0.26155150
120MET0.25738351
121LIMK10.25067126
122DAPK30.21947567
123CDK190.21884500
124MAP4K10.21877503
125MAPK110.21114399
126LATS10.20387240
127DYRK20.19408897
128ERBB40.18365673
129CDK180.17604800
130ALK0.17540347
131MELK0.17510777
132MAP3K100.16176620
133RAF10.15781163

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.91809781
2Proteasome_Homo sapiens_hsa030503.57644117
3Mismatch repair_Homo sapiens_hsa034303.42906573
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.00344055
5RNA polymerase_Homo sapiens_hsa030202.93026715
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.81748342
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.67627658
8Ribosome_Homo sapiens_hsa030102.63951187
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.49591285
10Base excision repair_Homo sapiens_hsa034102.47635703
11One carbon pool by folate_Homo sapiens_hsa006702.45129117
12Spliceosome_Homo sapiens_hsa030402.38866164
13RNA transport_Homo sapiens_hsa030132.38388026
14Pyrimidine metabolism_Homo sapiens_hsa002402.27079035
15Nucleotide excision repair_Homo sapiens_hsa034202.21240051
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.11411126
17Homologous recombination_Homo sapiens_hsa034402.09144173
18Biosynthesis of amino acids_Homo sapiens_hsa012301.98377718
19Carbon metabolism_Homo sapiens_hsa012001.91271515
20Parkinsons disease_Homo sapiens_hsa050121.78003428
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.77264406
22Oxidative phosphorylation_Homo sapiens_hsa001901.76001068
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.74320694
24Cell cycle_Homo sapiens_hsa041101.65668327
25Pyruvate metabolism_Homo sapiens_hsa006201.60539324
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59780615
27RNA degradation_Homo sapiens_hsa030181.55158473
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.48277955
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.43476487
30Propanoate metabolism_Homo sapiens_hsa006401.36284288
31Huntingtons disease_Homo sapiens_hsa050161.34173376
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.34059607
33Non-homologous end-joining_Homo sapiens_hsa034501.32560533
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.31855111
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.30561169
36Steroid biosynthesis_Homo sapiens_hsa001001.28055326
37Purine metabolism_Homo sapiens_hsa002301.24275349
38Fanconi anemia pathway_Homo sapiens_hsa034601.23793982
39Pentose phosphate pathway_Homo sapiens_hsa000301.21909796
40Basal transcription factors_Homo sapiens_hsa030221.20998458
41Folate biosynthesis_Homo sapiens_hsa007901.17913856
42Selenocompound metabolism_Homo sapiens_hsa004501.17119801
43Fatty acid degradation_Homo sapiens_hsa000711.11102826
44Primary bile acid biosynthesis_Homo sapiens_hsa001201.08027604
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.08009659
46Vitamin B6 metabolism_Homo sapiens_hsa007501.06325456
47Fructose and mannose metabolism_Homo sapiens_hsa000511.04260944
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94354814
49mRNA surveillance pathway_Homo sapiens_hsa030150.91144091
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.89872305
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88657747
52Glutathione metabolism_Homo sapiens_hsa004800.87779523
53Sulfur relay system_Homo sapiens_hsa041220.82919160
54Alzheimers disease_Homo sapiens_hsa050100.82403048
55Protein export_Homo sapiens_hsa030600.81859130
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80770428
57Galactose metabolism_Homo sapiens_hsa000520.80419573
58Peroxisome_Homo sapiens_hsa041460.79686760
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.76869465
60Tryptophan metabolism_Homo sapiens_hsa003800.74924990
61p53 signaling pathway_Homo sapiens_hsa041150.74781489
62Arginine biosynthesis_Homo sapiens_hsa002200.74298919
63Phenylalanine metabolism_Homo sapiens_hsa003600.73733098
64Lysine degradation_Homo sapiens_hsa003100.73631185
65Fatty acid metabolism_Homo sapiens_hsa012120.71605658
66Metabolic pathways_Homo sapiens_hsa011000.69089604
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68736915
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.68631613
69Epstein-Barr virus infection_Homo sapiens_hsa051690.67567320
70beta-Alanine metabolism_Homo sapiens_hsa004100.67387597
71Arginine and proline metabolism_Homo sapiens_hsa003300.65791850
72Butanoate metabolism_Homo sapiens_hsa006500.62691807
73Tyrosine metabolism_Homo sapiens_hsa003500.60280757
74Fatty acid elongation_Homo sapiens_hsa000620.59383414
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54599733
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53965210
77Oocyte meiosis_Homo sapiens_hsa041140.52411555
78Cardiac muscle contraction_Homo sapiens_hsa042600.48945256
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46987768
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45915946
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42586362
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40283799
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35929690
84Chemical carcinogenesis_Homo sapiens_hsa052040.35489879
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.35337841
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33317104
87Systemic lupus erythematosus_Homo sapiens_hsa053220.31208536
88Starch and sucrose metabolism_Homo sapiens_hsa005000.26598985
89Retinol metabolism_Homo sapiens_hsa008300.25673413
90Hippo signaling pathway_Homo sapiens_hsa043900.23731404
91Alcoholism_Homo sapiens_hsa050340.23614699
92N-Glycan biosynthesis_Homo sapiens_hsa005100.21941166
93Thyroid cancer_Homo sapiens_hsa052160.21005235
94Basal cell carcinoma_Homo sapiens_hsa052170.20979125
95Legionellosis_Homo sapiens_hsa051340.20512643
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.19374806
97TGF-beta signaling pathway_Homo sapiens_hsa043500.19344412
98MicroRNAs in cancer_Homo sapiens_hsa052060.19057942
99Sulfur metabolism_Homo sapiens_hsa009200.18833222
100Histidine metabolism_Homo sapiens_hsa003400.17235987
101Vitamin digestion and absorption_Homo sapiens_hsa049770.16088839
102Fat digestion and absorption_Homo sapiens_hsa049750.15587968
103Viral carcinogenesis_Homo sapiens_hsa052030.15093884
104Bladder cancer_Homo sapiens_hsa052190.15016914
105Antigen processing and presentation_Homo sapiens_hsa046120.14965849
106Steroid hormone biosynthesis_Homo sapiens_hsa001400.14820375
107Complement and coagulation cascades_Homo sapiens_hsa046100.14191625
108Wnt signaling pathway_Homo sapiens_hsa043100.12860882
109Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.12853296
110Adherens junction_Homo sapiens_hsa045200.10941804
111Hedgehog signaling pathway_Homo sapiens_hsa043400.09767131
112Small cell lung cancer_Homo sapiens_hsa052220.09265531
113Fatty acid biosynthesis_Homo sapiens_hsa000610.09146869
114Glucagon signaling pathway_Homo sapiens_hsa049220.08777015
115Regulation of autophagy_Homo sapiens_hsa041400.08676474
116Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.07929106
117Collecting duct acid secretion_Homo sapiens_hsa049660.07075500

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