MRPS28

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has been called mitochondrial ribosomal protein S35 in the literature. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.36489689
2ribosomal small subunit assembly (GO:0000028)6.30612246
3ATP synthesis coupled proton transport (GO:0015986)5.94524244
4energy coupled proton transport, down electrochemical gradient (GO:0015985)5.94524244
5ribosomal small subunit biogenesis (GO:0042274)5.82204014
6viral transcription (GO:0019083)5.80409459
7DNA deamination (GO:0045006)5.66226052
8translational termination (GO:0006415)5.63876098
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.37028807
10cotranslational protein targeting to membrane (GO:0006613)5.31426343
11protein targeting to ER (GO:0045047)5.26765367
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.12414833
13protein localization to endoplasmic reticulum (GO:0070972)5.03337565
14proteasome assembly (GO:0043248)5.02536781
15establishment of protein localization to endoplasmic reticulum (GO:0072599)5.00248493
16translational elongation (GO:0006414)4.98113245
17respiratory electron transport chain (GO:0022904)4.90286807
18maturation of SSU-rRNA (GO:0030490)4.86249082
19electron transport chain (GO:0022900)4.76738654
20ribosomal large subunit biogenesis (GO:0042273)4.71942533
21oxidative phosphorylation (GO:0006119)4.58517029
22translational initiation (GO:0006413)4.45452592
23cellular protein complex disassembly (GO:0043624)4.42158667
24viral life cycle (GO:0019058)4.39881284
25regulation of mitochondrial translation (GO:0070129)4.39456371
26translation (GO:0006412)4.38984437
27mitochondrial respiratory chain complex I assembly (GO:0032981)4.31133659
28NADH dehydrogenase complex assembly (GO:0010257)4.31133659
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.31133659
30nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.25189786
31ribonucleoprotein complex biogenesis (GO:0022613)4.12106401
32termination of RNA polymerase III transcription (GO:0006386)4.08238800
33transcription elongation from RNA polymerase III promoter (GO:0006385)4.08238800
34protein complex biogenesis (GO:0070271)4.03634105
35cytochrome complex assembly (GO:0017004)3.91211363
36L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.90489676
37cellular component biogenesis (GO:0044085)3.86968567
38mitochondrial respiratory chain complex assembly (GO:0033108)3.84793383
39establishment of protein localization to mitochondrial membrane (GO:0090151)3.83267614
40chromatin remodeling at centromere (GO:0031055)3.82290590
41negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.81868380
42protein neddylation (GO:0045116)3.81300176
43protein complex disassembly (GO:0043241)3.73269457
44pseudouridine synthesis (GO:0001522)3.70777450
45DNA strand elongation involved in DNA replication (GO:0006271)3.69742402
46telomere maintenance via semi-conservative replication (GO:0032201)3.67462160
47rRNA modification (GO:0000154)3.66734476
48deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.61656134
49cullin deneddylation (GO:0010388)3.59231399
50regulation of cellular amino acid metabolic process (GO:0006521)3.58412466
51macromolecular complex disassembly (GO:0032984)3.57700728
52formation of translation preinitiation complex (GO:0001731)3.57676570
53chaperone-mediated protein transport (GO:0072321)3.57234673
54establishment of integrated proviral latency (GO:0075713)3.56437191
55rRNA processing (GO:0006364)3.56148076
56water-soluble vitamin biosynthetic process (GO:0042364)3.56072131
57positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.51928965
58DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.51512029
59negative regulation of ligase activity (GO:0051352)3.51408034
60negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.51408034
61protein deneddylation (GO:0000338)3.51186365
62DNA strand elongation (GO:0022616)3.50561442
63intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.45409506
64signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.45409506
65regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.45220540
66inner mitochondrial membrane organization (GO:0007007)3.44932255
67signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.44168601
68signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.44168601
69signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.44168601
707-methylguanosine mRNA capping (GO:0006370)3.43850840
71protein targeting to membrane (GO:0006612)3.43630329
727-methylguanosine RNA capping (GO:0009452)3.42302005
73RNA capping (GO:0036260)3.42302005
74rRNA metabolic process (GO:0016072)3.41191980
75antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.38931437
76respiratory chain complex IV assembly (GO:0008535)3.38150437
77anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.37716302
78protein targeting to mitochondrion (GO:0006626)3.36519652
79peptidyl-histidine modification (GO:0018202)3.35628228
80signal transduction involved in DNA damage checkpoint (GO:0072422)3.35009456
81signal transduction involved in DNA integrity checkpoint (GO:0072401)3.35009456
82spliceosomal snRNP assembly (GO:0000387)3.33737948
83establishment of protein localization to mitochondrion (GO:0072655)3.32190818
84intracellular protein transmembrane import (GO:0044743)3.29334961
85signal transduction involved in cell cycle checkpoint (GO:0072395)3.29138637
86nuclear-transcribed mRNA catabolic process (GO:0000956)3.28208221
87amino acid salvage (GO:0043102)3.26780389
88L-methionine salvage (GO:0071267)3.26780389
89L-methionine biosynthetic process (GO:0071265)3.26780389
90hydrogen ion transmembrane transport (GO:1902600)3.25247060
91ribosome biogenesis (GO:0042254)3.25049757
92telomere maintenance via recombination (GO:0000722)3.24694528
93GTP biosynthetic process (GO:0006183)3.23968033
94protein localization to mitochondrion (GO:0070585)3.23701688
95nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.23156346
96purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.20859264
97purine nucleoside triphosphate biosynthetic process (GO:0009145)3.20796625
98rRNA methylation (GO:0031167)3.20288398
99ATP biosynthetic process (GO:0006754)3.19971044
100nucleobase biosynthetic process (GO:0046112)3.19496150
101transcription-coupled nucleotide-excision repair (GO:0006283)3.18030190
102exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.17351293
103positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.16040937
104antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.14696689
105purine nucleobase biosynthetic process (GO:0009113)3.14218272
106CENP-A containing nucleosome assembly (GO:0034080)3.12034138
107RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.11168498
108tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.11168498
109mRNA catabolic process (GO:0006402)3.11046345
110DNA replication checkpoint (GO:0000076)3.10705848
111nucleobase-containing small molecule interconversion (GO:0015949)3.10167069
112pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.08526836
113guanosine-containing compound biosynthetic process (GO:1901070)3.08132678
114aerobic respiration (GO:0009060)3.08027122
115histone exchange (GO:0043486)3.08007319
116protein-cofactor linkage (GO:0018065)3.04533615
117positive regulation of ligase activity (GO:0051351)3.03290030
118DNA damage response, detection of DNA damage (GO:0042769)2.99201747
119mitochondrial transport (GO:0006839)2.98389022
120ribonucleoside triphosphate biosynthetic process (GO:0009201)2.97957926
121proton transport (GO:0015992)2.96893453
122maturation of 5.8S rRNA (GO:0000460)2.92390648
123DNA double-strand break processing (GO:0000729)2.91512189
124hydrogen transport (GO:0006818)2.91279877
125nucleoside triphosphate biosynthetic process (GO:0009142)2.81459646
126regulation of ubiquitin-protein transferase activity (GO:0051438)2.77970181

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.69544686
2E2F7_22180533_ChIP-Seq_HELA_Human4.59435974
3* MYC_18555785_ChIP-Seq_MESCs_Mouse4.43785559
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.16262520
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.00556715
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.95255751
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.93806983
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.88989015
9* ETS1_20019798_ChIP-Seq_JURKAT_Human3.58222500
10* CREB1_15753290_ChIP-ChIP_HEK293T_Human3.46753824
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.25322108
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.18444104
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.17761530
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.98823857
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.88021186
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.86891813
17* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.77998266
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.75424695
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.71685479
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.68808854
21* VDR_23849224_ChIP-Seq_CD4+_Human2.50377826
22XRN2_22483619_ChIP-Seq_HELA_Human2.45856561
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.45138279
24* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.45064507
25DCP1A_22483619_ChIP-Seq_HELA_Human2.41955135
26SRF_21415370_ChIP-Seq_HL-1_Mouse2.37389732
27E2F4_17652178_ChIP-ChIP_JURKAT_Human2.32252293
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25911000
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.24502383
30THAP11_20581084_ChIP-Seq_MESCs_Mouse2.21975167
31* PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.20047752
32FOXP3_21729870_ChIP-Seq_TREG_Human2.14080924
33YY1_21170310_ChIP-Seq_MESCs_Mouse2.05188920
34TTF2_22483619_ChIP-Seq_HELA_Human2.02370979
35ELK1_19687146_ChIP-ChIP_HELA_Human2.01162484
36GABP_19822575_ChIP-Seq_HepG2_Human1.97943932
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.83047904
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.82558822
39VDR_22108803_ChIP-Seq_LS180_Human1.82386890
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78516807
41ZNF274_21170338_ChIP-Seq_K562_Hela1.76823872
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.72778837
43* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.70868400
44EWS_26573619_Chip-Seq_HEK293_Human1.69023209
45NANOG_18555785_ChIP-Seq_MESCs_Mouse1.67443322
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.67229099
47FUS_26573619_Chip-Seq_HEK293_Human1.67081096
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.66239110
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.64893395
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.61820981
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54703746
52PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.53751751
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.51195501
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.45355077
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.45325577
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43581755
57* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42065990
58CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.40993389
59ELK1_22589737_ChIP-Seq_MCF10A_Human1.40916138
60IGF1R_20145208_ChIP-Seq_DFB_Human1.36003298
61AR_21909140_ChIP-Seq_LNCAP_Human1.35305463
62BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.34844403
63POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.31768379
64FOXM1_23109430_ChIP-Seq_U2OS_Human1.30382932
65POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29694193
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24671388
67MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.24590813
68TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24522078
69CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19067525
70HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.18105282
71ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.18069309
72TP53_22573176_ChIP-Seq_HFKS_Human1.14315056
73CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.13575671
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11741825
75PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11495282
76ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10769231
77PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10665452
78E2F1_21310950_ChIP-Seq_MCF-7_Human1.10311223
79POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10303746
80P300_19829295_ChIP-Seq_ESCs_Human1.08930786
81MYC_18940864_ChIP-ChIP_HL60_Human1.08416152
82MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08210104
83NANOG_16153702_ChIP-ChIP_HESCs_Human1.07898086
84* CIITA_25753668_ChIP-Seq_RAJI_Human1.06529270
85HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05726969
86KDM5A_27292631_Chip-Seq_BREAST_Human1.05659523
87SOX2_16153702_ChIP-ChIP_HESCs_Human1.04765744
88DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.04412530
89HTT_18923047_ChIP-ChIP_STHdh_Human1.04344167
90HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04241215
91STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03641534
92TAF15_26573619_Chip-Seq_HEK293_Human1.03114274
93EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02645226
94TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02069490
95* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00788140
96POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00151847
97KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98217279
98NOTCH1_21737748_ChIP-Seq_TLL_Human0.96930477
99SALL1_21062744_ChIP-ChIP_HESCs_Human0.96251316
100GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95708102
101SOX2_19829295_ChIP-Seq_ESCs_Human0.95678098
102NANOG_19829295_ChIP-Seq_ESCs_Human0.95678098
103IRF1_19129219_ChIP-ChIP_H3396_Human0.92203678
104AR_20517297_ChIP-Seq_VCAP_Human0.91068445
105* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.90662750
106SOX17_20123909_ChIP-Seq_XEN_Mouse0.90485198
107CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89633883
108GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88095230
109* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.88059951
110E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.86683271
111RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.86622872
112CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86323195
113EGR1_23403033_ChIP-Seq_LIVER_Mouse0.85670698
114FOXA1_25329375_ChIP-Seq_VCAP_Human0.85623787
115FOXA1_27270436_Chip-Seq_PROSTATE_Human0.85623787
116TFEB_21752829_ChIP-Seq_HELA_Human0.85216124
117SOX2_18692474_ChIP-Seq_MEFs_Mouse0.84906676
118CTBP1_25329375_ChIP-Seq_LNCAP_Human0.84648484
119GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84459861
120SOX2_18555785_ChIP-Seq_MESCs_Mouse0.83890981
121OCT4_18692474_ChIP-Seq_MEFs_Mouse0.83094812
122TBX5_21415370_ChIP-Seq_HL-1_Mouse0.80328535
123SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.79810062
124* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79375001
125ER_23166858_ChIP-Seq_MCF-7_Human0.79275318
126EZH2_27294783_Chip-Seq_NPCs_Mouse0.78369207
127KLF4_18555785_ChIP-Seq_MESCs_Mouse0.78367358
128FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.77672539
129ERG_20517297_ChIP-Seq_VCAP_Human0.77064084
130SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.77010758
131DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.75407201
132SPI1_23547873_ChIP-Seq_NB4_Human0.72833156
133FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70970150
134YY1_22570637_ChIP-Seq_MALME-3M_Human0.66714644
135EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.65470789
136SRY_22984422_ChIP-ChIP_TESTIS_Rat0.65467047

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.67698884
2MP0003806_abnormal_nucleotide_metabolis4.64536531
3MP0009379_abnormal_foot_pigmentation3.89929364
4MP0004957_abnormal_blastocyst_morpholog3.67242536
5MP0003186_abnormal_redox_activity3.29725289
6MP0008057_abnormal_DNA_replication3.27157484
7MP0006036_abnormal_mitochondrial_physio3.24416094
8MP0010094_abnormal_chromosome_stability3.03325583
9MP0008058_abnormal_DNA_repair2.75042090
10MP0003111_abnormal_nucleus_morphology2.72514806
11MP0003077_abnormal_cell_cycle2.67803622
12MP0006072_abnormal_retinal_apoptosis2.49507859
13MP0003646_muscle_fatigue2.45403396
14MP0008932_abnormal_embryonic_tissue2.35045966
15MP0006035_abnormal_mitochondrial_morpho2.20274854
16MP0003718_maternal_effect2.06101979
17MP0004147_increased_porphyrin_level2.02568851
18MP0003786_premature_aging1.97079639
19MP0000749_muscle_degeneration1.96345349
20MP0008007_abnormal_cellular_replicative1.94394871
21MP0001529_abnormal_vocalization1.92107351
22MP0002132_abnormal_respiratory_system1.83903427
23MP0001984_abnormal_olfaction1.80019989
24MP0009697_abnormal_copulation1.78845632
25MP0002837_dystrophic_cardiac_calcinosis1.65820766
26MP0002102_abnormal_ear_morphology1.62955847
27MP0005253_abnormal_eye_physiology1.61292942
28MP0005266_abnormal_metabolism1.61153622
29MP0008875_abnormal_xenobiotic_pharmacok1.60003716
30MP0004145_abnormal_muscle_electrophysio1.59529387
31MP0003880_abnormal_central_pattern1.56032044
32MP0005551_abnormal_eye_electrophysiolog1.51841947
33MP0002234_abnormal_pharynx_morphology1.50235219
34MP0001764_abnormal_homeostasis1.48214522
35MP0004084_abnormal_cardiac_muscle1.47611576
36MP0005645_abnormal_hypothalamus_physiol1.43844737
37MP0003656_abnormal_erythrocyte_physiolo1.40569442
38MP0002736_abnormal_nociception_after1.39530499
39MP0002396_abnormal_hematopoietic_system1.36723031
40MP0004043_abnormal_pH_regulation1.36127365
41MP0001293_anophthalmia1.35035730
42MP0001730_embryonic_growth_arrest1.33809177
43MP0005330_cardiomyopathy1.32435981
44MP0000750_abnormal_muscle_regeneration1.32413937
45MP0009046_muscle_twitch1.31163951
46MP0005408_hypopigmentation1.30995318
47MP0009333_abnormal_splenocyte_physiolog1.30385962
48MP0002638_abnormal_pupillary_reflex1.28699913
49MP0001853_heart_inflammation1.26588977
50MP0000358_abnormal_cell_content/1.26313165
51MP0000631_abnormal_neuroendocrine_gland1.22803122
52MP0001485_abnormal_pinna_reflex1.20494628
53MP0000490_abnormal_crypts_of1.17309553
54MP0004215_abnormal_myocardial_fiber1.14627865
55MP0003195_calcinosis1.13209507
56MP0010386_abnormal_urinary_bladder1.12906886
57MP0003123_paternal_imprinting1.10606406
58MP0004036_abnormal_muscle_relaxation1.10098602
59MP0005389_reproductive_system_phenotype1.09635053
60MP0005451_abnormal_body_composition1.07650447
61MP0005636_abnormal_mineral_homeostasis1.06739261
62MP0001727_abnormal_embryo_implantation1.04715973
63MP0003137_abnormal_impulse_conducting1.02964168
64MP0002938_white_spotting1.02763703
65MP0010030_abnormal_orbit_morphology1.02556684
66MP0000350_abnormal_cell_proliferation1.02362302
67MP0002090_abnormal_vision1.01783719
68MP0005376_homeostasis/metabolism_phenot1.01341519
69MP0000313_abnormal_cell_death1.00853434
70MP0002876_abnormal_thyroid_physiology1.00848840
71MP0008995_early_reproductive_senescence0.99255922
72MP0003121_genomic_imprinting0.98619499
73MP0005646_abnormal_pituitary_gland0.97564461
74MP0001905_abnormal_dopamine_level0.96994396
75MP0002163_abnormal_gland_morphology0.96817604
76MP0008872_abnormal_physiological_respon0.96465221
77MP0001542_abnormal_bone_strength0.95912302
78MP0005332_abnormal_amino_acid0.95465308
79MP0002210_abnormal_sex_determination0.95447868
80MP0000372_irregular_coat_pigmentation0.94909882
81MP0003011_delayed_dark_adaptation0.94715418
82MP0001986_abnormal_taste_sensitivity0.94554689
83MP0003567_abnormal_fetal_cardiomyocyte0.91452769
84MP0001929_abnormal_gametogenesis0.90092672
85MP0005075_abnormal_melanosome_morpholog0.89679790
86MP0006276_abnormal_autonomic_nervous0.89210715
87MP0003221_abnormal_cardiomyocyte_apopto0.88785982
88MP0003937_abnormal_limbs/digits/tail_de0.87732040
89MP0001968_abnormal_touch/_nociception0.87336689
90MP0006054_spinal_hemorrhage0.86923216
91MP0002332_abnormal_exercise_endurance0.86337416
92MP0002269_muscular_atrophy0.85593500
93MP0003950_abnormal_plasma_membrane0.84646397
94MP0006292_abnormal_olfactory_placode0.84460188
95MP0002019_abnormal_tumor_incidence0.84413003
96MP0005084_abnormal_gallbladder_morpholo0.84101244
97MP0000049_abnormal_middle_ear0.83449375
98MP0005083_abnormal_biliary_tract0.83245595
99MP0002080_prenatal_lethality0.83144760
100MP0000647_abnormal_sebaceous_gland0.82848787
101MP0001697_abnormal_embryo_size0.82408679
102MP0002139_abnormal_hepatobiliary_system0.82294893
103MP0002272_abnormal_nervous_system0.81335294
104MP0005499_abnormal_olfactory_system0.80879888
105MP0005394_taste/olfaction_phenotype0.80879888
106MP0002653_abnormal_ependyma_morphology0.79690717
107MP0000653_abnormal_sex_gland0.79675322
108MP0003941_abnormal_skin_development0.79403563
109MP0004782_abnormal_surfactant_physiolog0.78619918
110MP0001145_abnormal_male_reproductive0.78152727
111MP0009745_abnormal_behavioral_response0.77106781
112MP0002751_abnormal_autonomic_nervous0.76864149
113MP0002095_abnormal_skin_pigmentation0.76314546
114MP0005195_abnormal_posterior_eye0.75986116
115MP0005365_abnormal_bile_salt0.75395302
116MP0004381_abnormal_hair_follicle0.74649910
117MP0004142_abnormal_muscle_tone0.74371114
118MP0005410_abnormal_fertilization0.73544374
119MP0001919_abnormal_reproductive_system0.73473282
120MP0005391_vision/eye_phenotype0.73056530
121MP0009643_abnormal_urine_homeostasis0.70588952
122MP0005380_embryogenesis_phenotype0.70413334
123MP0001672_abnormal_embryogenesis/_devel0.70413334
124MP0003984_embryonic_growth_retardation0.69561029
125MP0004133_heterotaxia0.69473023
126MP0003136_yellow_coat_color0.69138076
127MP0002233_abnormal_nose_morphology0.66986097
128MP0002106_abnormal_muscle_physiology0.66626025
129MP0005319_abnormal_enzyme/_coenzyme0.66588988
130MP0003698_abnormal_male_reproductive0.66557104
131MP0008877_abnormal_DNA_methylation0.66551045
132MP0004019_abnormal_vitamin_homeostasis0.66283976
133MP0000343_altered_response_to0.65977482
134MP0001544_abnormal_cardiovascular_syste0.65829315
135MP0005385_cardiovascular_system_phenoty0.65829315
136MP0005379_endocrine/exocrine_gland_phen0.65730957
137MP0003763_abnormal_thymus_physiology0.65392335
138MP0002088_abnormal_embryonic_growth/wei0.65242559
139MP0002127_abnormal_cardiovascular_syste0.64656426
140MP0003724_increased_susceptibility_to0.64480080
141MP0002972_abnormal_cardiac_muscle0.63834283
142MP0008789_abnormal_olfactory_epithelium0.62762231
143MP0005220_abnormal_exocrine_pancreas0.60826002
144MP0002148_abnormal_hypersensitivity_rea0.59837616
145MP0003315_abnormal_perineum_morphology0.58358645
146MP0000762_abnormal_tongue_morphology0.56242180
147MP0003828_pulmonary_edema0.55115931
148MP0002277_abnormal_respiratory_mucosa0.54068432
149MP0002160_abnormal_reproductive_system0.54030692
150MP0008873_increased_physiological_sensi0.53695254

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.32399552
2Abnormal mitochondria in muscle tissue (HP:0008316)5.81932022
3Mitochondrial inheritance (HP:0001427)5.66860093
4Acute encephalopathy (HP:0006846)5.37650526
5Abnormality of cells of the erythroid lineage (HP:0012130)5.35590946
6Hepatocellular necrosis (HP:0001404)5.26436088
7Hepatic necrosis (HP:0002605)5.20783579
8Abnormal number of erythroid precursors (HP:0012131)5.18795755
9Increased CSF lactate (HP:0002490)5.16447995
10Progressive macrocephaly (HP:0004481)5.00981387
11Increased hepatocellular lipid droplets (HP:0006565)4.66583485
12Lipid accumulation in hepatocytes (HP:0006561)4.42532325
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.29448717
14Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.12606885
15Decreased activity of mitochondrial respiratory chain (HP:0008972)4.12606885
16Cerebral edema (HP:0002181)3.99885490
17Increased serum lactate (HP:0002151)3.99872287
18Reticulocytopenia (HP:0001896)3.91376629
19Abnormality of glycolysis (HP:0004366)3.83799388
20Increased serum pyruvate (HP:0003542)3.83799388
21Exercise intolerance (HP:0003546)3.77001703
22Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.75940134
23Lactic acidosis (HP:0003128)3.75299004
24Renal Fanconi syndrome (HP:0001994)3.72591511
25Respiratory failure (HP:0002878)3.68213426
26Macrocytic anemia (HP:0001972)3.67669770
273-Methylglutaconic aciduria (HP:0003535)3.65457878
28Increased intramyocellular lipid droplets (HP:0012240)3.60457715
29Exertional dyspnea (HP:0002875)3.39587914
30Increased muscle lipid content (HP:0009058)3.27204566
31Respiratory difficulties (HP:0002880)3.20008959
32Birth length less than 3rd percentile (HP:0003561)3.08908222
33Leukodystrophy (HP:0002415)3.01325642
34Pallor (HP:0000980)2.92359399
35CNS demyelination (HP:0007305)2.82836858
36Optic disc pallor (HP:0000543)2.82266655
37Congenital, generalized hypertrichosis (HP:0004540)2.82136831
38Cerebral hypomyelination (HP:0006808)2.79931721
39Aplastic anemia (HP:0001915)2.76004019
40Aplasia/Hypoplasia of the sacrum (HP:0008517)2.69055232
41Lethargy (HP:0001254)2.66100931
42Microvesicular hepatic steatosis (HP:0001414)2.64162669
43Pancreatic cysts (HP:0001737)2.61507075
44Molar tooth sign on MRI (HP:0002419)2.59654519
45Abnormality of midbrain morphology (HP:0002418)2.59654519
46Dicarboxylic aciduria (HP:0003215)2.56340859
47Abnormality of dicarboxylic acid metabolism (HP:0010995)2.56340859
48Breast hypoplasia (HP:0003187)2.54102394
49Glycosuria (HP:0003076)2.52550919
50Abnormality of urine glucose concentration (HP:0011016)2.52550919
51Type I transferrin isoform profile (HP:0003642)2.50419125
52Hyperglycinemia (HP:0002154)2.50104081
53Pancreatic fibrosis (HP:0100732)2.45925383
54Oral leukoplakia (HP:0002745)2.45785498
55True hermaphroditism (HP:0010459)2.45283903
56Generalized aminoaciduria (HP:0002909)2.43853198
57Carpal bone hypoplasia (HP:0001498)2.43452048
58Abnormality of serum amino acid levels (HP:0003112)2.38104541
59Abnormality of renal resorption (HP:0011038)2.34553051
60Abnormality of methionine metabolism (HP:0010901)2.31038342
61Abnormality of the heme biosynthetic pathway (HP:0010472)2.30813112
62Multiple enchondromatosis (HP:0005701)2.21770555
63Emotional lability (HP:0000712)2.20751343
64Progressive muscle weakness (HP:0003323)2.20432352
65Rhabdomyolysis (HP:0003201)2.18552996
66Abnormality of aspartate family amino acid metabolism (HP:0010899)2.17110355
67Nausea (HP:0002018)2.16624638
68Methylmalonic aciduria (HP:0012120)2.14300045
69Rough bone trabeculation (HP:0100670)2.12754127
70Medial flaring of the eyebrow (HP:0010747)2.08274705
71Irregular epiphyses (HP:0010582)2.07391529
72Colon cancer (HP:0003003)2.04652016
73Hyperphosphaturia (HP:0003109)2.00213060
74Hypoplasia of the pons (HP:0012110)1.98738986
75Abnormality of the pons (HP:0007361)1.97175436
76Nephronophthisis (HP:0000090)1.94375052
77Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.94012793
78Palpitations (HP:0001962)1.93600894
79Hypoglycemic coma (HP:0001325)1.93113114
80Hyperglycinuria (HP:0003108)1.91182962
81Pancytopenia (HP:0001876)1.89581348
82Abnormality of alanine metabolism (HP:0010916)1.88001941
83Hyperalaninemia (HP:0003348)1.88001941
84Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.88001941
85Aplasia/hypoplasia of the uterus (HP:0008684)1.87237308
86Gliosis (HP:0002171)1.86859321
87Abnormality of fatty-acid metabolism (HP:0004359)1.86632061
88Large for gestational age (HP:0001520)1.84561245
89Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.83103856
9011 pairs of ribs (HP:0000878)1.81909065
91Pendular nystagmus (HP:0012043)1.81756967
92Abnormality of glycine metabolism (HP:0010895)1.81724252
93Abnormality of serine family amino acid metabolism (HP:0010894)1.81724252
94Microretrognathia (HP:0000308)1.80994618
95Hyperinsulinemic hypoglycemia (HP:0000825)1.79561602
96Meckel diverticulum (HP:0002245)1.79261947
97Abnormal protein N-linked glycosylation (HP:0012347)1.78105999
98Abnormal protein glycosylation (HP:0012346)1.78105999
99Abnormal glycosylation (HP:0012345)1.78105999
100Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.78105999
101Abnormality of the labia minora (HP:0012880)1.76373338
102Vomiting (HP:0002013)1.76249317
103Abnormal hemoglobin (HP:0011902)1.75582604
104Absent thumb (HP:0009777)1.75415781
105Sclerocornea (HP:0000647)1.75375416
106Secondary amenorrhea (HP:0000869)1.75257220
107Degeneration of anterior horn cells (HP:0002398)1.73968659
108Abnormality of the anterior horn cell (HP:0006802)1.73968659
109Trismus (HP:0000211)1.73471729
110Renal cortical cysts (HP:0000803)1.73346033
111Methylmalonic acidemia (HP:0002912)1.73279273
112Abnormality of the ileum (HP:0001549)1.72616640
113Abnormality of aromatic amino acid family metabolism (HP:0004338)1.72612422
114Septo-optic dysplasia (HP:0100842)1.72079007
115Abnormality of vitamin B metabolism (HP:0004340)1.70658925
116CNS hypomyelination (HP:0003429)1.70180658
117Ragged-red muscle fibers (HP:0003200)1.67784415
118Sparse eyelashes (HP:0000653)1.67455029
119Blindness (HP:0000618)1.66536161
120X-linked dominant inheritance (HP:0001423)1.65577399
121Male pseudohermaphroditism (HP:0000037)1.65268006
122Aplasia/Hypoplasia of the uvula (HP:0010293)1.64987518
123Hypothermia (HP:0002045)1.63619827
124Proximal tubulopathy (HP:0000114)1.62898224
125Abnormality of reticulocytes (HP:0004312)1.60278629
126Stenosis of the external auditory canal (HP:0000402)1.60160406
127Abnormal urine phosphate concentration (HP:0012599)1.57341345
128Abnormal trabecular bone morphology (HP:0100671)1.56906737
129Amniotic constriction ring (HP:0009775)1.56443325
130Abnormality of placental membranes (HP:0011409)1.56443325
131Reduced antithrombin III activity (HP:0001976)1.56062270
132Megaloblastic anemia (HP:0001889)1.55209331
133Renal tubular dysfunction (HP:0000124)1.54477846

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.78421611
2BUB14.34640809
3VRK23.92140372
4STK163.85325462
5EIF2AK13.17076198
6WEE13.08201942
7VRK12.68911273
8NME12.67544448
9EIF2AK32.55037411
10BCKDK2.42481527
11PBK2.19030011
12PLK42.15278200
13NUAK12.14618357
14SRPK12.13569355
15PIM22.05991390
16MST41.92235935
17TESK21.89495268
18MAP3K121.89236366
19FRK1.86700934
20WNK31.85797986
21MAP4K21.83966631
22TLK11.82246805
23ZAK1.72668170
24TSSK61.69465562
25BRSK21.62455876
26OBSCN1.51583537
27TAF11.51085619
28TRIM281.49957450
29KDR1.46753197
30TNIK1.45478236
31BRAF1.32177902
32GRK11.31921675
33MKNK11.25920277
34MYLK1.21159453
35PASK1.21031681
36MAP3K31.20823089
37PLK11.20176430
38CDC71.20149825
39ACVR1B1.19574754
40IRAK31.18479999
41AURKA1.16931220
42AURKB1.16888350
43TTK1.13839247
44RPS6KB21.13294534
45CCNB11.10700029
46CDK81.09435964
47ABL21.06509283
48LIMK11.03624093
49IRAK41.02702940
50TESK11.01640350
51PHKG11.01112295
52PHKG21.01112295
53DYRK30.99976200
54ERBB30.97986001
55CSNK1G30.97551119
56NEK10.97521997
57PLK30.97176801
58CSNK1G20.96982249
59BRSK10.95391182
60CSNK1G10.94625223
61PDK20.91656448
62INSRR0.89462503
63MAP2K70.89226497
64CDK70.88828385
65MAP3K40.87500852
66MAPKAPK50.87451205
67OXSR10.86250241
68MAP3K110.84414654
69DYRK20.83417595
70PDK30.79576686
71PDK40.79576686
72PNCK0.79454221
73CSNK2A10.79075206
74EIF2AK20.78644841
75STK40.78304290
76ARAF0.77213000
77ILK0.77204615
78EPHA20.74054483
79RPS6KA50.72830744
80MKNK20.71586075
81CSNK2A20.71541204
82ATR0.70083649
83MUSK0.69035255
84AKT30.68771469
85PLK20.68194910
86WNK40.66223387
87MAP2K20.65908114
88CHEK20.63140562
89MAP2K30.62188321
90PAK10.61399126
91CSNK1A1L0.60718434
92MAP3K80.58143717
93PIK3CG0.57217723
94PINK10.55671324
95GRK70.55145199
96TEC0.53149562
97PRKCG0.52921219
98CDK30.52491597
99RPS6KA40.52327983
100PRKCE0.51901911
101STK38L0.51757331
102TGFBR10.49955472
103STK30.49885859
104STK240.48217816
105BMPR1B0.48024407
106NEK20.47946316
107MAPK130.46535128
108BCR0.45923161
109MAPKAPK30.44801047
110MAPK150.44603634
111ATM0.43255403
112PIM10.42120867
113TXK0.41597433
114CDK190.41201785
115STK390.40837986
116DAPK10.38727947
117ADRBK10.38608205
118DAPK30.38148929
119MOS0.37751091
120PAK30.37747245
121PRKCI0.36259389
122LRRK20.35808892
123CSNK1A10.35214258
124BTK0.34858989
125CSNK1E0.33342409
126PRKACA0.33161227
127CHEK10.31954013
128MAP2K60.30531681
129CLK10.30368725
130ADRBK20.30055508
131TIE10.29297211
132IRAK10.28978000
133PRKACB0.28977791
134CAMK2D0.27669438
135TAOK20.27278966
136CDK40.27266006
137FLT30.26945779
138IKBKB0.26689897
139RPS6KA60.26432269
140PAK40.26330143

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.92079780
2Oxidative phosphorylation_Homo sapiens_hsa001903.96480700
3Proteasome_Homo sapiens_hsa030503.93728130
4Parkinsons disease_Homo sapiens_hsa050123.59220242
5RNA polymerase_Homo sapiens_hsa030203.41090133
6DNA replication_Homo sapiens_hsa030303.17930867
7Protein export_Homo sapiens_hsa030602.85412412
8Huntingtons disease_Homo sapiens_hsa050162.62118460
9Mismatch repair_Homo sapiens_hsa034302.60973606
10Alzheimers disease_Homo sapiens_hsa050102.39041792
11Pyrimidine metabolism_Homo sapiens_hsa002402.34909253
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.33080762
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.30261099
14Homologous recombination_Homo sapiens_hsa034402.08512714
15Spliceosome_Homo sapiens_hsa030402.01907503
16Nucleotide excision repair_Homo sapiens_hsa034201.88110840
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.87154179
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.86532213
19Base excision repair_Homo sapiens_hsa034101.84561342
20RNA transport_Homo sapiens_hsa030131.60900158
21Folate biosynthesis_Homo sapiens_hsa007901.50669753
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.47337782
23Cardiac muscle contraction_Homo sapiens_hsa042601.45983092
24One carbon pool by folate_Homo sapiens_hsa006701.44603691
25Non-homologous end-joining_Homo sapiens_hsa034501.42954760
26RNA degradation_Homo sapiens_hsa030181.36504398
27Fatty acid elongation_Homo sapiens_hsa000621.34880884
28Purine metabolism_Homo sapiens_hsa002301.30333415
29Basal transcription factors_Homo sapiens_hsa030221.28998834
30Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.24908570
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.23260212
32Glutathione metabolism_Homo sapiens_hsa004801.22443492
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.18173618
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13074177
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.12291687
36Carbon metabolism_Homo sapiens_hsa012001.10242180
37Sulfur metabolism_Homo sapiens_hsa009201.07465124
38Fanconi anemia pathway_Homo sapiens_hsa034601.05801558
39Propanoate metabolism_Homo sapiens_hsa006401.02711784
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.01119399
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00915855
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.00680913
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00673882
44Pyruvate metabolism_Homo sapiens_hsa006200.97314235
45Cell cycle_Homo sapiens_hsa041100.95756176
46Metabolic pathways_Homo sapiens_hsa011000.89042556
47Drug metabolism - other enzymes_Homo sapiens_hsa009830.86850130
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.85016457
49Pentose phosphate pathway_Homo sapiens_hsa000300.85003085
50Primary bile acid biosynthesis_Homo sapiens_hsa001200.84892967
51Biosynthesis of amino acids_Homo sapiens_hsa012300.84550262
52Phototransduction_Homo sapiens_hsa047440.81094968
53Sulfur relay system_Homo sapiens_hsa041220.77510390
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.74418242
55Arginine and proline metabolism_Homo sapiens_hsa003300.74333283
56Arachidonic acid metabolism_Homo sapiens_hsa005900.73880074
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72729622
58Vitamin B6 metabolism_Homo sapiens_hsa007500.71633861
59Peroxisome_Homo sapiens_hsa041460.70883851
60Nitrogen metabolism_Homo sapiens_hsa009100.68190412
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64991383
62Caffeine metabolism_Homo sapiens_hsa002320.62399616
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62226795
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60609322
65Fatty acid degradation_Homo sapiens_hsa000710.59366446
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57590200
67Epstein-Barr virus infection_Homo sapiens_hsa051690.55519042
68p53 signaling pathway_Homo sapiens_hsa041150.55513252
69Linoleic acid metabolism_Homo sapiens_hsa005910.54281567
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52172749
71Tyrosine metabolism_Homo sapiens_hsa003500.51133787
72Chemical carcinogenesis_Homo sapiens_hsa052040.50204266
73Cyanoamino acid metabolism_Homo sapiens_hsa004600.49744078
74Phenylalanine metabolism_Homo sapiens_hsa003600.48809369
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48482511
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48355473
77Galactose metabolism_Homo sapiens_hsa000520.48181375
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47439768
79Systemic lupus erythematosus_Homo sapiens_hsa053220.46532778
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45921089
81Fructose and mannose metabolism_Homo sapiens_hsa000510.45571124
82Oocyte meiosis_Homo sapiens_hsa041140.44576780
83Collecting duct acid secretion_Homo sapiens_hsa049660.44380251
84Steroid biosynthesis_Homo sapiens_hsa001000.42948703
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41552222
86Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40672285
87Selenocompound metabolism_Homo sapiens_hsa004500.40511550
88N-Glycan biosynthesis_Homo sapiens_hsa005100.39905028
89beta-Alanine metabolism_Homo sapiens_hsa004100.39838929
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.38972472
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36640154
92Vitamin digestion and absorption_Homo sapiens_hsa049770.36441008
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35563997
94Fatty acid metabolism_Homo sapiens_hsa012120.34259706
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33327547
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33037324
97Regulation of autophagy_Homo sapiens_hsa041400.32594413
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32125037
99mRNA surveillance pathway_Homo sapiens_hsa030150.31213194
100Histidine metabolism_Homo sapiens_hsa003400.30043360
101Butanoate metabolism_Homo sapiens_hsa006500.29709865
102Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.25715957
103Legionellosis_Homo sapiens_hsa051340.25216829
104Nicotine addiction_Homo sapiens_hsa050330.23393169
105Vibrio cholerae infection_Homo sapiens_hsa051100.22122355
106Retinol metabolism_Homo sapiens_hsa008300.20987919
107Other glycan degradation_Homo sapiens_hsa005110.20386383
108Taste transduction_Homo sapiens_hsa047420.18682682
109Steroid hormone biosynthesis_Homo sapiens_hsa001400.17437919
110Sphingolipid metabolism_Homo sapiens_hsa006000.14675805
111Tryptophan metabolism_Homo sapiens_hsa003800.13226052
112Fat digestion and absorption_Homo sapiens_hsa049750.10861200
113Antigen processing and presentation_Homo sapiens_hsa046120.10189146
114Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.08760141
115Starch and sucrose metabolism_Homo sapiens_hsa005000.08267494
116Ether lipid metabolism_Homo sapiens_hsa005650.07645767

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