MRPS30

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that is similar to the chicken pro-apoptotic protein p52. Transcript variants using alternative promoters or polyA sites have been mentioned in the literature but the complete description of these sequences is not available. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.57246208
2ribosomal small subunit assembly (GO:0000028)5.25500307
3viral transcription (GO:0019083)5.03671463
4maturation of SSU-rRNA (GO:0030490)5.01248352
5translational termination (GO:0006415)4.95069812
6DNA deamination (GO:0045006)4.69180840
7ribosomal small subunit biogenesis (GO:0042274)4.68526335
8folic acid-containing compound biosynthetic process (GO:0009396)4.68318928
9translational elongation (GO:0006414)4.48779244
10DNA strand elongation involved in DNA replication (GO:0006271)4.43271875
11ribosomal large subunit biogenesis (GO:0042273)4.41063396
12formation of translation preinitiation complex (GO:0001731)4.35592749
13translational initiation (GO:0006413)4.33367923
14mitotic sister chromatid cohesion (GO:0007064)4.27346098
15DNA strand elongation (GO:0022616)4.19307464
16nucleobase biosynthetic process (GO:0046112)4.17937316
17DNA replication initiation (GO:0006270)4.12359527
18purine nucleobase biosynthetic process (GO:0009113)4.08940101
19nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.07001314
20pore complex assembly (GO:0046931)4.05123397
21ribonucleoprotein complex biogenesis (GO:0022613)4.03669854
22sister chromatid segregation (GO:0000819)4.02111166
23DNA unwinding involved in DNA replication (GO:0006268)4.01459672
24telomere maintenance via semi-conservative replication (GO:0032201)3.99271606
25ribosome assembly (GO:0042255)3.98728094
26SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.98138464
27protein targeting to ER (GO:0045047)3.86995882
28cotranslational protein targeting to membrane (GO:0006613)3.86580055
29cellular protein complex disassembly (GO:0043624)3.83067003
30viral life cycle (GO:0019058)3.81464451
31ribosome biogenesis (GO:0042254)3.76352534
32folic acid metabolic process (GO:0046655)3.75303464
33regulation of centriole replication (GO:0046599)3.72255888
34establishment of protein localization to endoplasmic reticulum (GO:0072599)3.69510665
35regulation of mitochondrial translation (GO:0070129)3.69330539
36DNA replication checkpoint (GO:0000076)3.65444841
37protein localization to endoplasmic reticulum (GO:0070972)3.65418505
38double-strand break repair via nonhomologous end joining (GO:0006303)3.65301636
39non-recombinational repair (GO:0000726)3.65301636
40establishment of integrated proviral latency (GO:0075713)3.63955018
41IMP biosynthetic process (GO:0006188)3.63594434
42mitotic nuclear envelope disassembly (GO:0007077)3.61762921
43mitotic metaphase plate congression (GO:0007080)3.60837661
44rRNA processing (GO:0006364)3.58238894
45mitotic chromosome condensation (GO:0007076)3.53441326
46rRNA metabolic process (GO:0016072)3.44760985
47glycine metabolic process (GO:0006544)3.44387898
48transcription from mitochondrial promoter (GO:0006390)3.44315527
49protein complex disassembly (GO:0043241)3.42975015
50pseudouridine synthesis (GO:0001522)3.42589607
51DNA replication-dependent nucleosome assembly (GO:0006335)3.41666873
52DNA replication-dependent nucleosome organization (GO:0034723)3.41666873
53telomere maintenance via recombination (GO:0000722)3.40928515
54IMP metabolic process (GO:0046040)3.40244989
55protein localization to kinetochore (GO:0034501)3.38885900
56spliceosomal snRNP assembly (GO:0000387)3.38152416
57pteridine-containing compound biosynthetic process (GO:0042559)3.36756695
58regulation of mitotic spindle organization (GO:0060236)3.36637096
59membrane disassembly (GO:0030397)3.31267200
60nuclear envelope disassembly (GO:0051081)3.31267200
61regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.31194855
62* translation (GO:0006412)3.28288113
63macromolecular complex disassembly (GO:0032984)3.25752408
64chromatin remodeling at centromere (GO:0031055)3.24511230
65telomere maintenance via telomere lengthening (GO:0010833)3.23480799
66protein localization to chromosome, centromeric region (GO:0071459)3.23046414
67DNA topological change (GO:0006265)3.21729246
68rRNA modification (GO:0000154)3.21097473
69mitotic recombination (GO:0006312)3.18240100
70negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.18019160
71regulation of centrosome cycle (GO:0046605)3.14109284
72spindle checkpoint (GO:0031577)3.11717420
73nuclear-transcribed mRNA catabolic process (GO:0000956)3.11640070
74mitotic spindle checkpoint (GO:0071174)3.10707581
75DNA double-strand break processing (GO:0000729)3.10408670
76CENP-A containing nucleosome assembly (GO:0034080)3.09600111
77cellular component biogenesis (GO:0044085)3.09439594
78histone exchange (GO:0043486)3.09107372
79regulation of DNA endoreduplication (GO:0032875)3.09000977
80regulation of translational fidelity (GO:0006450)3.03895268
81kinetochore organization (GO:0051383)3.02298708
82ncRNA catabolic process (GO:0034661)3.00726322
83regulation of mitotic metaphase/anaphase transition (GO:0030071)2.99275101
84regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.99275101
85maturation of 5.8S rRNA (GO:0000460)2.97860217
86nucleotide-excision repair, DNA gap filling (GO:0006297)2.97751096
87proteasome assembly (GO:0043248)2.97608859
88somatic recombination of immunoglobulin gene segments (GO:0016447)2.97105581
89mitochondrial RNA metabolic process (GO:0000959)2.96954514
90metaphase plate congression (GO:0051310)2.95970953
91regulation of spindle organization (GO:0090224)2.95102572
92tetrahydrofolate metabolic process (GO:0046653)2.94814039
93mRNA catabolic process (GO:0006402)2.94578273
94regulation of sister chromatid segregation (GO:0033045)2.94340188
95regulation of mitotic sister chromatid separation (GO:0010965)2.94340188
96regulation of mitotic sister chromatid segregation (GO:0033047)2.94340188
97regulation of chromosome segregation (GO:0051983)2.93772418
98RNA catabolic process (GO:0006401)2.93669834
99nuclear pore organization (GO:0006999)2.91593403
100oxidative phosphorylation (GO:0006119)2.90905743
101somatic diversification of immune receptors via somatic mutation (GO:0002566)2.90122983
102somatic hypermutation of immunoglobulin genes (GO:0016446)2.90122983
103tRNA aminoacylation for protein translation (GO:0006418)2.89847657
104somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.89487822
105isotype switching (GO:0045190)2.89487822
106somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.89487822
107tRNA aminoacylation (GO:0043039)2.88172970
108amino acid activation (GO:0043038)2.88172970
109DNA replication-independent nucleosome assembly (GO:0006336)2.88141752
110DNA replication-independent nucleosome organization (GO:0034724)2.88141752
111serine family amino acid biosynthetic process (GO:0009070)2.84601983
112folic acid-containing compound metabolic process (GO:0006760)2.84377576
113spliceosomal complex assembly (GO:0000245)2.83689848
114anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.81652927
115mitochondrial DNA metabolic process (GO:0032042)2.81609237
116negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.80165896
117DNA ligation (GO:0006266)2.80145652
118regulation of centrosome duplication (GO:0010824)2.79596610
119regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.79180429
120L-serine metabolic process (GO:0006563)2.78969631
121mitotic sister chromatid segregation (GO:0000070)2.78714865
122attachment of spindle microtubules to kinetochore (GO:0008608)2.77376048
123negative regulation of chromosome segregation (GO:0051985)2.77007854
124regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.75210890
125positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.73142495
126negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.72707152
127nucleobase-containing small molecule interconversion (GO:0015949)2.72221348
128chromosome segregation (GO:0007059)2.71228180
129negative regulation of mitotic sister chromatid separation (GO:2000816)2.70906417
130negative regulation of mitotic sister chromatid segregation (GO:0033048)2.70906417
131negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.70906417
132negative regulation of sister chromatid segregation (GO:0033046)2.70906417
133nuclear envelope organization (GO:0006998)2.70805787
134protein complex localization (GO:0031503)2.70767011
135regulation of translational termination (GO:0006449)2.70733611
136negative regulation of translational initiation (GO:0045947)2.70627570
137histone mRNA metabolic process (GO:0008334)2.69671572
138DNA duplex unwinding (GO:0032508)2.68050866
139mitotic spindle assembly checkpoint (GO:0007094)2.67071556
140pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.66779027
141DNA geometric change (GO:0032392)2.66336780
142regulation of gene silencing by RNA (GO:0060966)2.66080539
143regulation of posttranscriptional gene silencing (GO:0060147)2.66080539
144regulation of gene silencing by miRNA (GO:0060964)2.66080539
145spindle assembly checkpoint (GO:0071173)2.65288772
146ncRNA 3-end processing (GO:0043628)2.64761376

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.01908039
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.56094815
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.09030137
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.40924590
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.03125957
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.99876110
7* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.92568782
8MYC_19030024_ChIP-ChIP_MESCs_Mouse2.83957867
9* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.83468457
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.76505579
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.69216612
12* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.69075492
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.66786841
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.65290789
15* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.58507857
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.40476866
17XRN2_22483619_ChIP-Seq_HELA_Human2.39448474
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.27457442
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.27386947
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.16243156
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.10864981
22VDR_23849224_ChIP-Seq_CD4+_Human2.08121230
23* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.06935886
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.04089533
25DCP1A_22483619_ChIP-Seq_HELA_Human2.00367186
26AR_21909140_ChIP-Seq_LNCAP_Human1.92887242
27GABP_19822575_ChIP-Seq_HepG2_Human1.84936407
28* FOXP3_21729870_ChIP-Seq_TREG_Human1.81487518
29MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79206152
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.75247022
31* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.73751743
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.73160906
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.72186515
34E2F1_21310950_ChIP-Seq_MCF-7_Human1.71828616
35NANOG_18555785_ChIP-Seq_MESCs_Mouse1.71554347
36STAT3_1855785_ChIP-Seq_MESCs_Mouse1.70407502
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.70237902
38TTF2_22483619_ChIP-Seq_HELA_Human1.70150504
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.67293723
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.64528361
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.64334010
42* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.63232821
43ELF1_17652178_ChIP-ChIP_JURKAT_Human1.63083509
44MYC_22102868_ChIP-Seq_BL_Human1.61616435
45PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.58987822
46PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.58853050
47ESR1_15608294_ChIP-ChIP_MCF-7_Human1.55165239
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53145882
49* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52689220
50POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.48891847
51* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.48427128
52EGR1_19374776_ChIP-ChIP_THP-1_Human1.45535115
53KDM5A_27292631_Chip-Seq_BREAST_Human1.43879197
54SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.43575879
55CIITA_25753668_ChIP-Seq_RAJI_Human1.40272510
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.38988508
57KLF4_18555785_ChIP-Seq_MESCs_Mouse1.38179373
58* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33490537
59ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.30598347
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27013991
61ZNF263_19887448_ChIP-Seq_K562_Human1.26683768
62DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26649864
63POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.26522758
64ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26119371
65EWS_26573619_Chip-Seq_HEK293_Human1.25707312
66* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24437539
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24047712
68* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.24032083
69FUS_26573619_Chip-Seq_HEK293_Human1.22566485
70* ELK1_19687146_ChIP-ChIP_HELA_Human1.22511373
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22385770
72SRF_21415370_ChIP-Seq_HL-1_Mouse1.20490868
73KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.19774766
74VDR_21846776_ChIP-Seq_THP-1_Human1.19210177
75CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.17069660
76KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15528456
77TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14563620
78RBPJ_22232070_ChIP-Seq_NCS_Mouse1.14377107
79FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.13449707
80CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.13330802
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12509833
82TFEB_21752829_ChIP-Seq_HELA_Human1.09864172
83* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.09218652
84KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07714194
85NOTCH1_21737748_ChIP-Seq_TLL_Human1.06868042
86E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06378667
87* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06111748
88TCF3_18692474_ChIP-Seq_MEFs_Mouse1.04512341
89SOX2_16153702_ChIP-ChIP_HESCs_Human1.04383523
90SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02783043
91BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02747626
92SOX17_20123909_ChIP-Seq_XEN_Mouse1.01744227
93CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01444816
94SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.00478411
95MYC_18940864_ChIP-ChIP_HL60_Human0.99303159
96NANOG_16153702_ChIP-ChIP_HESCs_Human0.98886440
97TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98831498
98OCT4_18692474_ChIP-Seq_MEFs_Mouse0.97926140
99SOX2_18692474_ChIP-Seq_MEFs_Mouse0.96650111
100NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.93823908
101NANOG_21062744_ChIP-ChIP_HESCs_Human0.93289607
102CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.92121194
103GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91019153
104ELK1_22589737_ChIP-Seq_MCF10A_Human0.90211189
105* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90063697
106* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.88678771
107PADI4_21655091_ChIP-ChIP_MCF-7_Human0.87930326
108CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.87157897
109* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87145511
110PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.87121624
111CHD1_26751641_Chip-Seq_LNCaP_Human0.85880214
112PPARA_22158963_ChIP-Seq_LIVER_Mouse0.84531218
113* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.84036730
114CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.83250992
115POU5F1_16153702_ChIP-ChIP_HESCs_Human0.83167383
116SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.83152305
117IGF1R_20145208_ChIP-Seq_DFB_Human0.75929998
118RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.75922123
119* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.75891057
120HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.74262443
121GATA4_21415370_ChIP-Seq_HL-1_Mouse0.73638376
122SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.72532822

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.57285911
2MP0004957_abnormal_blastocyst_morpholog4.15167380
3MP0003111_abnormal_nucleus_morphology3.90416764
4MP0010094_abnormal_chromosome_stability3.86398280
5MP0003077_abnormal_cell_cycle3.47159571
6MP0003806_abnormal_nucleotide_metabolis3.34155285
7MP0002009_preneoplasia3.05911322
8MP0009840_abnormal_foam_cell2.96124760
9MP0008057_abnormal_DNA_replication2.74996934
10MP0009697_abnormal_copulation2.55470331
11MP0008058_abnormal_DNA_repair2.46597547
12MP0008932_abnormal_embryonic_tissue2.39425421
13MP0001730_embryonic_growth_arrest2.21229190
14MP0010352_gastrointestinal_tract_polyps2.06761950
15MP0003123_paternal_imprinting2.06240480
16MP0008007_abnormal_cellular_replicative2.05670285
17MP0000350_abnormal_cell_proliferation1.94974058
18MP0003221_abnormal_cardiomyocyte_apopto1.93340863
19MP0002396_abnormal_hematopoietic_system1.84512348
20MP0010307_abnormal_tumor_latency1.75141677
21MP0000490_abnormal_crypts_of1.71099976
22MP0003718_maternal_effect1.69737099
23MP0005380_embryogenesis_phenotype1.68754358
24MP0001672_abnormal_embryogenesis/_devel1.68754358
25MP0006036_abnormal_mitochondrial_physio1.67947059
26MP0001697_abnormal_embryo_size1.67757910
27MP0005360_urolithiasis1.62883824
28MP0003786_premature_aging1.60160453
29MP0003186_abnormal_redox_activity1.58945571
30MP0002080_prenatal_lethality1.58436779
31MP0002139_abnormal_hepatobiliary_system1.56540132
32MP0003984_embryonic_growth_retardation1.55492107
33MP0003567_abnormal_fetal_cardiomyocyte1.54677438
34MP0002088_abnormal_embryonic_growth/wei1.53987667
35MP0003941_abnormal_skin_development1.52081768
36MP0003937_abnormal_limbs/digits/tail_de1.50551252
37MP0004233_abnormal_muscle_weight1.49028531
38MP0006292_abnormal_olfactory_placode1.48883015
39MP0005083_abnormal_biliary_tract1.46031649
40MP0002160_abnormal_reproductive_system1.43409328
41MP0002837_dystrophic_cardiac_calcinosis1.43056662
42MP0003646_muscle_fatigue1.42465645
43MP0001188_hyperpigmentation1.41043997
44MP0001661_extended_life_span1.35553249
45MP0002019_abnormal_tumor_incidence1.35426725
46MP0002086_abnormal_extraembryonic_tissu1.34846693
47MP0002085_abnormal_embryonic_tissue1.34652299
48MP0004145_abnormal_muscle_electrophysio1.33527637
49MP0000750_abnormal_muscle_regeneration1.32094174
50MP0002877_abnormal_melanocyte_morpholog1.32022948
51MP0000313_abnormal_cell_death1.30924538
52MP0006035_abnormal_mitochondrial_morpho1.28399370
53MP0004197_abnormal_fetal_growth/weight/1.26190674
54MP0009333_abnormal_splenocyte_physiolog1.25759190
55MP0005076_abnormal_cell_differentiation1.23699697
56MP0002084_abnormal_developmental_patter1.22304870
57MP0003705_abnormal_hypodermis_morpholog1.22122116
58MP0000358_abnormal_cell_content/1.20064214
59MP0004215_abnormal_myocardial_fiber1.15931036
60MP0005187_abnormal_penis_morphology1.14789416
61MP0009379_abnormal_foot_pigmentation1.13944644
62MP0005085_abnormal_gallbladder_physiolo1.12409843
63MP0003656_abnormal_erythrocyte_physiolo1.11440614
64MP0004808_abnormal_hematopoietic_stem1.10656147
65MP0008995_early_reproductive_senescence1.10053658
66MP0005397_hematopoietic_system_phenotyp1.09155754
67MP0001545_abnormal_hematopoietic_system1.09155754
68MP0004036_abnormal_muscle_relaxation1.08296744
69MP0005365_abnormal_bile_salt0.97836997
70MP0002269_muscular_atrophy0.97420856
71MP0005319_abnormal_enzyme/_coenzyme0.96749248
72MP0002697_abnormal_eye_size0.95134886
73MP0003119_abnormal_digestive_system0.94993534
74MP0000689_abnormal_spleen_morphology0.94540311
75MP0005332_abnormal_amino_acid0.94361895
76MP0002722_abnormal_immune_system0.93693193
77MP0003315_abnormal_perineum_morphology0.92043494
78MP0005266_abnormal_metabolism0.91753377
79MP0000703_abnormal_thymus_morphology0.91319731
80MP0008877_abnormal_DNA_methylation0.91274780
81MP0005023_abnormal_wound_healing0.90975341
82MP0002234_abnormal_pharynx_morphology0.90872965
83MP0000749_muscle_degeneration0.90833030
84MP0001764_abnormal_homeostasis0.90559967
85MP0000372_irregular_coat_pigmentation0.89204150
86MP0001853_heart_inflammation0.88920506
87MP0000598_abnormal_liver_morphology0.88888691
88MP0001145_abnormal_male_reproductive0.87887526
89MP0002210_abnormal_sex_determination0.87407218
90MP0000609_abnormal_liver_physiology0.85059515
91MP0004087_abnormal_muscle_fiber0.84879431
92MP0001293_anophthalmia0.84552669
93MP0002398_abnormal_bone_marrow0.84547908
94MP0004133_heterotaxia0.83977141
95MP0005330_cardiomyopathy0.83765518
96MP0010030_abnormal_orbit_morphology0.81111093
97MP0000569_abnormal_digit_pigmentation0.80410969
98MP0001529_abnormal_vocalization0.80138047
99MP0001727_abnormal_embryo_implantation0.79919892
100MP0004084_abnormal_cardiac_muscle0.77105802
101MP0004185_abnormal_adipocyte_glucose0.75065686
102MP0001929_abnormal_gametogenesis0.73097649
103MP0000477_abnormal_intestine_morphology0.73069626
104MP0001286_abnormal_eye_development0.72590322
105MP0002429_abnormal_blood_cell0.72454647
106MP0002092_abnormal_eye_morphology0.72053457
107MP0003763_abnormal_thymus_physiology0.70304179
108MP0009672_abnormal_birth_weight0.69156045
109MP0009703_decreased_birth_body0.68461854
110MP0000537_abnormal_urethra_morphology0.68113685
111MP0000653_abnormal_sex_gland0.67812852
112MP0006072_abnormal_retinal_apoptosis0.67734073
113MP0000858_altered_metastatic_potential0.66266488
114MP0003137_abnormal_impulse_conducting0.66057532
115MP0005384_cellular_phenotype0.65821021
116MP0000015_abnormal_ear_pigmentation0.65340197
117MP0009053_abnormal_anal_canal0.64775073
118MP0002970_abnormal_white_adipose0.64711804
119MP0006138_congestive_heart_failure0.64558303
120MP0004147_increased_porphyrin_level0.64456953
121MP0000747_muscle_weakness0.64348790
122MP0002106_abnormal_muscle_physiology0.63510423
123MP0005666_abnormal_adipose_tissue0.63464488
124MP0002132_abnormal_respiratory_system0.63423015
125MP0000647_abnormal_sebaceous_gland0.62711425
126MP0000685_abnormal_immune_system0.62638851
127MP0000733_abnormal_muscle_development0.62606741
128MP0008775_abnormal_heart_ventricle0.62500468
129MP0003890_abnormal_embryonic-extraembry0.62396304
130MP0003385_abnormal_body_wall0.61440163
131MP0010630_abnormal_cardiac_muscle0.61416334
132MP0000759_abnormal_skeletal_muscle0.60836724
133MP0002177_abnormal_outer_ear0.60162982
134MP0002111_abnormal_tail_morphology0.60060594
135MP0003699_abnormal_female_reproductive0.59773337
136MP0005621_abnormal_cell_physiology0.59668228
137MP0009278_abnormal_bone_marrow0.58197865
138MP0005408_hypopigmentation0.57399373
139MP0005376_homeostasis/metabolism_phenot0.57216568
140MP0002095_abnormal_skin_pigmentation0.56888901

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.10593572
2Abnormality of cells of the erythroid lineage (HP:0012130)5.02695912
3Abnormal number of erythroid precursors (HP:0012131)4.86897496
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.74894915
5Chromsome breakage (HP:0040012)3.71629009
6Macrocytic anemia (HP:0001972)3.58695910
7Birth length less than 3rd percentile (HP:0003561)3.53151930
8Oral leukoplakia (HP:0002745)3.42165715
9Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.40293483
10Abnormality of alanine metabolism (HP:0010916)3.40293483
11Hyperalaninemia (HP:0003348)3.40293483
12Multiple enchondromatosis (HP:0005701)3.29027978
13Pallor (HP:0000980)3.26753964
14Abnormality of the anterior horn cell (HP:0006802)3.11843893
15Degeneration of anterior horn cells (HP:0002398)3.11843893
16Colon cancer (HP:0003003)3.10736238
17Progressive muscle weakness (HP:0003323)3.06719591
18Volvulus (HP:0002580)3.05522522
19Carpal bone hypoplasia (HP:0001498)3.01661437
20Selective tooth agenesis (HP:0001592)2.93977188
21Breast hypoplasia (HP:0003187)2.91784312
22Reduced antithrombin III activity (HP:0001976)2.91131162
23Abnormality of methionine metabolism (HP:0010901)2.87355567
24Decreased activity of mitochondrial respiratory chain (HP:0008972)2.87195082
25Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.87195082
26Type I transferrin isoform profile (HP:0003642)2.86132107
27Exercise-induced muscle cramps (HP:0003710)2.80215741
28Microretrognathia (HP:0000308)2.78915647
29Aplasia/Hypoplasia of the uvula (HP:0010293)2.77907104
30Hyperglycinemia (HP:0002154)2.71786883
31Abnormality of pyrimidine metabolism (HP:0004353)2.66559212
32Rough bone trabeculation (HP:0100670)2.64319879
33Increased serum lactate (HP:0002151)2.63041676
34Premature ovarian failure (HP:0008209)2.59773778
35Hyperglycinuria (HP:0003108)2.58090907
36Nausea (HP:0002018)2.57036803
37Abnormality of reticulocytes (HP:0004312)2.56249179
38Abnormality of glycolysis (HP:0004366)2.54225187
39Increased serum pyruvate (HP:0003542)2.54225187
40Abnormality of serum amino acid levels (HP:0003112)2.54207852
41Hypobetalipoproteinemia (HP:0003563)2.52853514
42Abnormality of the ileum (HP:0001549)2.52518883
43Trismus (HP:0000211)2.50593141
44Hepatic necrosis (HP:0002605)2.49884176
45Ependymoma (HP:0002888)2.48049285
46Absent thumb (HP:0009777)2.45990360
47Aplastic anemia (HP:0001915)2.43204160
48Rhabdomyosarcoma (HP:0002859)2.42519130
49Nemaline bodies (HP:0003798)2.40635429
50Rhabdomyolysis (HP:0003201)2.40451678
51Abnormal mitochondria in muscle tissue (HP:0008316)2.38785347
52Hepatocellular necrosis (HP:0001404)2.38339470
53Thrombocytosis (HP:0001894)2.37690352
54Overlapping toe (HP:0001845)2.36237183
55Central scotoma (HP:0000603)2.35635305
56Myoglobinuria (HP:0002913)2.34704299
57Abnormality of glycine metabolism (HP:0010895)2.34666910
58Abnormality of serine family amino acid metabolism (HP:0010894)2.34666910
59Muscle fiber inclusion bodies (HP:0100299)2.33800256
60Cerebral hypomyelination (HP:0006808)2.31926386
61Hyperammonemia (HP:0001987)2.31015592
62Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.30101220
63Abnormality of the intrinsic pathway (HP:0010989)2.28791424
64Ragged-red muscle fibers (HP:0003200)2.27983795
65Increased muscle lipid content (HP:0009058)2.27838894
66Secondary amenorrhea (HP:0000869)2.25116409
67Increased intramyocellular lipid droplets (HP:0012240)2.24745581
68Myelodysplasia (HP:0002863)2.23170687
69Increased nuchal translucency (HP:0010880)2.21625309
70Small intestinal stenosis (HP:0012848)2.21302392
71Duodenal stenosis (HP:0100867)2.21302392
72Abnormal protein glycosylation (HP:0012346)2.20665996
73Abnormal glycosylation (HP:0012345)2.20665996
74Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.20665996
75Abnormal protein N-linked glycosylation (HP:0012347)2.20665996
76Neoplasm of the pancreas (HP:0002894)2.20264885
77Acute necrotizing encephalopathy (HP:0006965)2.20134995
78Acute encephalopathy (HP:0006846)2.18189683
79Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.16315380
80Medulloblastoma (HP:0002885)2.12621374
81Progressive external ophthalmoplegia (HP:0000590)2.11750256
82Abnormality of monocarboxylic acid metabolism (HP:0010996)2.11213466
83CNS demyelination (HP:0007305)2.11031109
84Premature graying of hair (HP:0002216)2.08390968
85Microvesicular hepatic steatosis (HP:0001414)2.06365358
86Patellar aplasia (HP:0006443)2.05464914
87Abnormality of the astrocytes (HP:0100707)2.04843291
88Astrocytoma (HP:0009592)2.04843291
89Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.04301541
90Nephroblastoma (Wilms tumor) (HP:0002667)2.03964831
91Impulsivity (HP:0100710)2.03945907
92Homocystinuria (HP:0002156)2.00295535
93Abnormality of homocysteine metabolism (HP:0010919)2.00295535
94Atrophy/Degeneration involving motor neurons (HP:0007373)1.99214160
95Adenoma sebaceum (HP:0009720)1.98278528
96Angiofibromas (HP:0010615)1.98278528
97Abnormal hemoglobin (HP:0011902)1.98188311
98Exercise intolerance (HP:0003546)1.98171281
99Spastic diplegia (HP:0001264)1.98010955
100Abnormality of dicarboxylic acid metabolism (HP:0010995)1.97834198
101Dicarboxylic aciduria (HP:0003215)1.97834198
102Lipid accumulation in hepatocytes (HP:0006561)1.97536407
103Cleft eyelid (HP:0000625)1.96674853
104Basal cell carcinoma (HP:0002671)1.96336245
105Glioma (HP:0009733)1.95594359
106Proximal placement of thumb (HP:0009623)1.95077443
107Abnormality of chromosome stability (HP:0003220)1.94491092
108Rimmed vacuoles (HP:0003805)1.94343569
109Aplasia/Hypoplasia of the patella (HP:0006498)1.93520767
110Papillary thyroid carcinoma (HP:0002895)1.93109365
111Lactic acidosis (HP:0003128)1.92520275
112Embryonal renal neoplasm (HP:0011794)1.90866475
113Emotional lability (HP:0000712)1.89641004
114Sparse lateral eyebrow (HP:0005338)1.89158555
115Mitochondrial inheritance (HP:0001427)1.88808749
116Increased hepatocellular lipid droplets (HP:0006565)1.88804667
117Absent radius (HP:0003974)1.88314158
118Renal cortical cysts (HP:0000803)1.84660221
119Abnormality of the heme biosynthetic pathway (HP:0010472)1.84571909
120Abnormality of the carotid arteries (HP:0005344)1.84325487
121Abnormality of the duodenum (HP:0002246)1.83724138
122Lethargy (HP:0001254)1.83495597
123Abnormal lung lobation (HP:0002101)1.83249336
124Sloping forehead (HP:0000340)1.82927116
125Cellular immunodeficiency (HP:0005374)1.82899454
126Increased CSF lactate (HP:0002490)1.82796408
127Megaloblastic anemia (HP:0001889)1.82694320
128Neoplasm of the small intestine (HP:0100833)1.79568314
129Deviation of the thumb (HP:0009603)1.79568059
130Increased serum ferritin (HP:0003281)1.79306080
131Agnosia (HP:0010524)1.79023439
132Progressive macrocephaly (HP:0004481)1.77999837
133Muscle fiber atrophy (HP:0100295)1.77200488
134Pelvic girdle muscle weakness (HP:0003749)1.76747793
135Neoplasm of the colon (HP:0100273)1.76690430
136Abnormality of aspartate family amino acid metabolism (HP:0010899)1.76562806
137Aplasia/Hypoplasia of the sacrum (HP:0008517)1.76418875
138Abnormality of placental membranes (HP:0011409)1.76037272
139Amniotic constriction ring (HP:0009775)1.76037272
140Poikiloderma (HP:0001029)1.75336997
141Neoplasm of striated muscle (HP:0009728)1.75179899
142Triphalangeal thumb (HP:0001199)1.74272426
143Short middle phalanx of the 5th finger (HP:0004220)1.74030709
144Cerebral edema (HP:0002181)1.74025648
145Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.73705653
146Abnormal trabecular bone morphology (HP:0100671)1.73531287
147Sparse eyelashes (HP:0000653)1.72850623
148Aplasia involving forearm bones (HP:0009822)1.72310747
149Absent forearm bone (HP:0003953)1.72310747
150Horizontal nystagmus (HP:0000666)1.72212670
151Meckel diverticulum (HP:0002245)1.71022751
152Abnormality of sulfur amino acid metabolism (HP:0004339)1.70878055
15311 pairs of ribs (HP:0000878)1.70346758
154Personality changes (HP:0000751)1.69827997
155Neuroendocrine neoplasm (HP:0100634)1.69315372
156Abnormality of the preputium (HP:0100587)1.68199073
157Cutaneous melanoma (HP:0012056)1.67049300
158Glossoptosis (HP:0000162)1.66978949
159Shoulder girdle muscle weakness (HP:0003547)1.62164833

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.43378503
2WEE13.95956873
3NEK13.51204701
4EIF2AK13.50471444
5NME23.01907645
6NEK22.95773451
7CDC72.89217459
8TLK12.87222119
9STK162.35722209
10BCKDK2.29601058
11ACVR1B2.14417091
12OBSCN2.02195214
13RPS6KB21.96719035
14MAP3K111.96333396
15PKN21.90084112
16TTK1.88066831
17EEF2K1.86978401
18SCYL21.75791169
19TESK21.73287440
20FLT31.68706613
21EIF2AK31.67854895
22PLK11.66298222
23DYRK31.65874176
24SRPK11.54702757
25MST1R1.53492388
26PLK41.53226712
27TSSK61.51939806
28BRSK21.48269070
29TRIB31.47605445
30VRK11.47017515
31CDK41.45223214
32AURKB1.45162000
33CDK71.41973912
34RPS6KA41.38760387
35EPHA21.35731843
36MAP3K81.35128725
37MAPKAPK31.29102618
38BRD41.26215566
39VRK21.21353023
40MAP2K31.19607761
41CHEK21.18525218
42STK101.15347469
43MAP4K11.15160946
44AURKA1.14066433
45TRIM281.14030102
46MAP3K101.11124202
47ATR1.08068929
48CDK191.07098279
49STK391.06872666
50LRRK21.06202934
51PAK41.05388320
52MAP3K41.03484906
53MST41.02209800
54PDK30.98836748
55PDK40.98836748
56TGFBR10.97279484
57STK40.97224838
58WNK40.94117790
59MAP2K70.92413146
60KDR0.92056886
61ERBB30.91229665
62CDK30.90976066
63CAMKK20.89686394
64TAOK20.89414317
65CSNK1G10.89122687
66CSNK1G30.88802537
67CSNK1A1L0.88422615
68CDK120.83768182
69NUAK10.83699684
70PASK0.81606466
71EIF2AK20.81560870
72CHEK10.81137422
73PIM20.80439516
74PBK0.78700474
75PLK30.78306945
76MAP3K30.75643351
77CSNK1G20.75420191
78PIM10.75193429
79TAF10.72980891
80BMPR1B0.72543925
81LATS20.69518084
82LATS10.69475310
83BRSK10.68788033
84PNCK0.67711917
85MAP3K50.66840678
86NEK60.63511293
87PAK10.62554993
88NME10.61400522
89CDK60.61091482
90ILK0.60417113
91CDK20.60395242
92CSNK2A20.59683234
93MAPKAPK50.56605212
94ERBB40.56337271
95BCR0.56082720
96OXSR10.54600949
97MET0.54590640
98RAF10.54453105
99BRAF0.54330267
100CAMK1D0.53366861
101CCNB10.53075998
102CSNK2A10.52448261
103AKT20.52147071
104PHKG20.50645029
105PHKG10.50645029
106PRKDC0.50497554
107ATM0.49908184
108STK30.48687285
109ALK0.48678785
110BLK0.48319735
111GRK60.47728474
112AKT30.47448327
113MAPK110.46340925
114RPS6KB10.45374850
115STK38L0.44121160
116PRKCI0.43649325
117CAMK1G0.43051173
118MTOR0.42943019
119MAP3K60.41958168
120MKNK10.41633025
121MELK0.40267664
122RPS6KA50.38858424
123TTN0.38196030
124CLK10.37548662
125CDK80.36763209
126MKNK20.35997417
127ZAK0.32954139
128ABL20.32293427
129CDK10.31804505
130TAOK10.30734172
131TESK10.30364279
132PDK20.28733526
133MARK30.28645600
134CSF1R0.28464399
135DYRK20.27156281
136ZAP700.25243180
137DAPK30.23836155
138CSNK1E0.23489015

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.43354309
2Ribosome_Homo sapiens_hsa030104.09386267
3Mismatch repair_Homo sapiens_hsa034303.48759064
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.18664333
5One carbon pool by folate_Homo sapiens_hsa006702.83158041
6Proteasome_Homo sapiens_hsa030502.77439415
7Spliceosome_Homo sapiens_hsa030402.74339230
8RNA transport_Homo sapiens_hsa030132.60189641
9RNA polymerase_Homo sapiens_hsa030202.57503885
10Base excision repair_Homo sapiens_hsa034102.49390824
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.44096950
12Nucleotide excision repair_Homo sapiens_hsa034202.34455015
13Pyrimidine metabolism_Homo sapiens_hsa002402.26901484
14Homologous recombination_Homo sapiens_hsa034402.13412250
15Cell cycle_Homo sapiens_hsa041102.07093173
16Biosynthesis of amino acids_Homo sapiens_hsa012301.72542359
17Sulfur relay system_Homo sapiens_hsa041221.67982813
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.65222384
19Selenocompound metabolism_Homo sapiens_hsa004501.63969690
20Folate biosynthesis_Homo sapiens_hsa007901.61671416
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.61278580
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.59691064
23Pentose phosphate pathway_Homo sapiens_hsa000301.55165616
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.54397050
25Carbon metabolism_Homo sapiens_hsa012001.50775675
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.50192009
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.49182233
28RNA degradation_Homo sapiens_hsa030181.32637305
29Protein export_Homo sapiens_hsa030601.26041388
30Fanconi anemia pathway_Homo sapiens_hsa034601.22429054
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.18770946
32p53 signaling pathway_Homo sapiens_hsa041151.16273432
33Non-homologous end-joining_Homo sapiens_hsa034501.15786574
34Vitamin B6 metabolism_Homo sapiens_hsa007501.14584101
35Systemic lupus erythematosus_Homo sapiens_hsa053221.13901813
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.12618907
37Basal transcription factors_Homo sapiens_hsa030221.10226971
38Purine metabolism_Homo sapiens_hsa002301.03878888
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.03788657
40mRNA surveillance pathway_Homo sapiens_hsa030151.02757506
41Alcoholism_Homo sapiens_hsa050341.01550392
42Propanoate metabolism_Homo sapiens_hsa006400.98660680
43Fatty acid degradation_Homo sapiens_hsa000710.95678097
44Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.95434459
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93176085
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88654192
47Epstein-Barr virus infection_Homo sapiens_hsa051690.85813393
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85379092
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85159647
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.83532452
51Pyruvate metabolism_Homo sapiens_hsa006200.81326860
52Parkinsons disease_Homo sapiens_hsa050120.78136464
53Glutathione metabolism_Homo sapiens_hsa004800.76158691
54Steroid biosynthesis_Homo sapiens_hsa001000.74577704
55Fatty acid elongation_Homo sapiens_hsa000620.73647517
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73244523
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72776580
58Cardiac muscle contraction_Homo sapiens_hsa042600.70152316
59Huntingtons disease_Homo sapiens_hsa050160.69927900
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69850296
61Arginine biosynthesis_Homo sapiens_hsa002200.67334796
62Antigen processing and presentation_Homo sapiens_hsa046120.67005214
63Fructose and mannose metabolism_Homo sapiens_hsa000510.66986586
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66970664
65Viral carcinogenesis_Homo sapiens_hsa052030.65859812
66Arginine and proline metabolism_Homo sapiens_hsa003300.63306585
67Sulfur metabolism_Homo sapiens_hsa009200.62396953
68Oocyte meiosis_Homo sapiens_hsa041140.60022870
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.59646625
70Herpes simplex infection_Homo sapiens_hsa051680.59062811
71Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58921638
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.54029280
73Oxidative phosphorylation_Homo sapiens_hsa001900.49482394
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48548795
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48512101
76Metabolic pathways_Homo sapiens_hsa011000.48185977
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45194533
78HTLV-I infection_Homo sapiens_hsa051660.43382686
79Fatty acid metabolism_Homo sapiens_hsa012120.43007515
80beta-Alanine metabolism_Homo sapiens_hsa004100.40930001
81Peroxisome_Homo sapiens_hsa041460.40628357
82Galactose metabolism_Homo sapiens_hsa000520.40185010
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.39438149
84Fat digestion and absorption_Homo sapiens_hsa049750.37876638
85Tryptophan metabolism_Homo sapiens_hsa003800.37846082
86Legionellosis_Homo sapiens_hsa051340.37638191
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37275918
88Thyroid cancer_Homo sapiens_hsa052160.36988319
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.36711853
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35795914
91Bladder cancer_Homo sapiens_hsa052190.33556829
92Small cell lung cancer_Homo sapiens_hsa052220.32562192
93Phenylalanine metabolism_Homo sapiens_hsa003600.29202798
94TGF-beta signaling pathway_Homo sapiens_hsa043500.27890115
95Fatty acid biosynthesis_Homo sapiens_hsa000610.27535318
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.25817705
97Lysine degradation_Homo sapiens_hsa003100.24451492
98Vitamin digestion and absorption_Homo sapiens_hsa049770.24145173
99Primary immunodeficiency_Homo sapiens_hsa053400.24000353
100Nitrogen metabolism_Homo sapiens_hsa009100.23886586
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.23882500
102Apoptosis_Homo sapiens_hsa042100.22167145
103Hippo signaling pathway_Homo sapiens_hsa043900.21915253
104Regulation of autophagy_Homo sapiens_hsa041400.20483537
105Circadian rhythm_Homo sapiens_hsa047100.20151154
106HIF-1 signaling pathway_Homo sapiens_hsa040660.19559043
107Retinol metabolism_Homo sapiens_hsa008300.18789438
108MicroRNAs in cancer_Homo sapiens_hsa052060.18591998
109Butanoate metabolism_Homo sapiens_hsa006500.17630599
110Caffeine metabolism_Homo sapiens_hsa002320.17398500
111PPAR signaling pathway_Homo sapiens_hsa033200.15854542
112N-Glycan biosynthesis_Homo sapiens_hsa005100.15829041
113mTOR signaling pathway_Homo sapiens_hsa041500.15544137
114AMPK signaling pathway_Homo sapiens_hsa041520.14605748
115Shigellosis_Homo sapiens_hsa051310.14361369
116Transcriptional misregulation in cancer_Homo sapiens_hsa052020.14109601
117Acute myeloid leukemia_Homo sapiens_hsa052210.13997121
118Alzheimers disease_Homo sapiens_hsa050100.13681256
119Tyrosine metabolism_Homo sapiens_hsa003500.13619863
120Glucagon signaling pathway_Homo sapiens_hsa049220.11279872
121Colorectal cancer_Homo sapiens_hsa052100.07917390
122Wnt signaling pathway_Homo sapiens_hsa043100.07416016

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