MRPS31

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. The 28S subunit of the mammalian mitoribosome may play a crucial and characteristic role in translation initiation. This gene encodes a 28S subunit protein that has also been associated with type 1 diabetes; however, its relationship to the etiology of this disease remains to be clarified. Pseudogenes corresponding to this gene have been found on chromosomes 3 and 13. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.08122260
2energy coupled proton transport, down electrochemical gradient (GO:0015985)4.60746310
3ATP synthesis coupled proton transport (GO:0015986)4.60746310
4protein complex biogenesis (GO:0070271)4.33113537
5purine nucleobase biosynthetic process (GO:0009113)4.26854766
6nucleobase biosynthetic process (GO:0046112)4.02802939
7respiratory chain complex IV assembly (GO:0008535)3.92971340
8maturation of SSU-rRNA (GO:0030490)3.92068133
9exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.90355657
10nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.90090416
11L-phenylalanine metabolic process (GO:0006558)3.81530230
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.81530230
13protein neddylation (GO:0045116)3.79249449
14L-phenylalanine catabolic process (GO:0006559)3.77552930
15erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.77552930
16glycine metabolic process (GO:0006544)3.77237137
17mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.76731156
18establishment of protein localization to mitochondrial membrane (GO:0090151)3.73419198
19serine family amino acid biosynthetic process (GO:0009070)3.72707676
20cytochrome complex assembly (GO:0017004)3.71384498
21respiratory electron transport chain (GO:0022904)3.70481312
22oxidative phosphorylation (GO:0006119)3.69696018
23SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.63280447
24cotranslational protein targeting to membrane (GO:0006613)3.61901612
25L-serine metabolic process (GO:0006563)3.61326999
26electron transport chain (GO:0022900)3.60761001
27protein targeting to ER (GO:0045047)3.56890368
28ribosome assembly (GO:0042255)3.50243462
29proteasome assembly (GO:0043248)3.50047922
30ribosomal large subunit biogenesis (GO:0042273)3.48503676
31DNA double-strand break processing (GO:0000729)3.46133227
32amino acid salvage (GO:0043102)3.46109110
33L-methionine salvage (GO:0071267)3.46109110
34L-methionine biosynthetic process (GO:0071265)3.46109110
35establishment of protein localization to endoplasmic reticulum (GO:0072599)3.42632344
36protein localization to endoplasmic reticulum (GO:0070972)3.36534915
37regulation of mitochondrial translation (GO:0070129)3.33324988
38serine family amino acid metabolic process (GO:0009069)3.32091653
39rRNA methylation (GO:0031167)3.29209295
40water-soluble vitamin biosynthetic process (GO:0042364)3.27687869
41pseudouridine synthesis (GO:0001522)3.23135325
42tricarboxylic acid cycle (GO:0006099)3.21551403
43folic acid metabolic process (GO:0046655)3.21071621
44glyoxylate metabolic process (GO:0046487)3.20605075
45rRNA modification (GO:0000154)3.19623480
46cullin deneddylation (GO:0010388)3.19361622
47DNA deamination (GO:0045006)3.18859487
48formation of translation preinitiation complex (GO:0001731)3.17505587
49serine family amino acid catabolic process (GO:0009071)3.17312668
50epithelial cilium movement (GO:0003351)3.15830434
51L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.15825489
52negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.15523845
53mitotic metaphase plate congression (GO:0007080)3.15116566
54DNA catabolic process, exonucleolytic (GO:0000738)3.14679246
55DNA damage response, detection of DNA damage (GO:0042769)3.13255413
56tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.09773700
57RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.09773700
58protein-cofactor linkage (GO:0018065)3.09627689
59epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.08399477
60peptidyl-histidine modification (GO:0018202)3.07309558
61mitochondrial respiratory chain complex I assembly (GO:0032981)3.06981883
62NADH dehydrogenase complex assembly (GO:0010257)3.06981883
63mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.06981883
64regulation of cellular amino acid metabolic process (GO:0006521)3.06730035
65NADH metabolic process (GO:0006734)3.04670462
66positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.03991829
67regulation of mitotic spindle checkpoint (GO:1903504)3.03743289
68regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.03743289
69histone exchange (GO:0043486)3.03174956
70quinone biosynthetic process (GO:1901663)3.02288183
71ubiquinone biosynthetic process (GO:0006744)3.02288183
72aromatic amino acid family catabolic process (GO:0009074)3.00342178
73protein localization to mitochondrion (GO:0070585)3.00084214
74chaperone-mediated protein complex assembly (GO:0051131)2.99718252
75viral transcription (GO:0019083)2.99550828
76ribonucleoprotein complex biogenesis (GO:0022613)2.99490997
77cellular ketone body metabolic process (GO:0046950)2.99354836
78regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.98987413
79histone mRNA metabolic process (GO:0008334)2.98751583
80translational termination (GO:0006415)2.98252227
81ribosomal small subunit biogenesis (GO:0042274)2.97668553
82DNA ligation (GO:0006266)2.97577761
83pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.97541646
84anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.97007766
85rRNA processing (GO:0006364)2.95655658
86protein deneddylation (GO:0000338)2.95587546
87DNA replication checkpoint (GO:0000076)2.95412606
88establishment of integrated proviral latency (GO:0075713)2.94457474
89sulfur amino acid biosynthetic process (GO:0000097)2.92768155
90purine nucleoside triphosphate biosynthetic process (GO:0009145)2.92433151
91ribosomal small subunit assembly (GO:0000028)2.90109271
92DNA strand elongation involved in DNA replication (GO:0006271)2.89632267
93purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.88965013
94signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.88905786
95signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.88905786
96signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.88905786
97intracellular protein transmembrane import (GO:0044743)2.88138129
98folic acid-containing compound biosynthetic process (GO:0009396)2.88133634
99ribosome biogenesis (GO:0042254)2.88050546
100negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.86510084
101negative regulation of ligase activity (GO:0051352)2.86510084
102viral life cycle (GO:0019058)2.86038592
103centriole replication (GO:0007099)2.85919396
104GTP biosynthetic process (GO:0006183)2.85597215
105chromatin remodeling at centromere (GO:0031055)2.85073964
106cellular protein complex disassembly (GO:0043624)2.83497405
107rRNA metabolic process (GO:0016072)2.82938448
108protein K6-linked ubiquitination (GO:0085020)2.82892945
109aspartate family amino acid catabolic process (GO:0009068)2.82823876
110spliceosomal snRNP assembly (GO:0000387)2.82494725
1117-methylguanosine mRNA capping (GO:0006370)2.82492304
112intraciliary transport (GO:0042073)2.81998739
113methionine biosynthetic process (GO:0009086)2.81773748
114cellular component biogenesis (GO:0044085)2.81723596
115cilium movement (GO:0003341)2.81361361
116nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.80796251
117methionine metabolic process (GO:0006555)2.80736082
118axonemal dynein complex assembly (GO:0070286)2.79722026
119lysine metabolic process (GO:0006553)2.79476411
120lysine catabolic process (GO:0006554)2.79476411
121hydrogen ion transmembrane transport (GO:1902600)2.79397802
122cysteine metabolic process (GO:0006534)2.79357465
123translational elongation (GO:0006414)2.78903031
124DNA replication initiation (GO:0006270)2.78603495
125branched-chain amino acid catabolic process (GO:0009083)2.77541844
126aldehyde catabolic process (GO:0046185)2.77353363
127DNA strand elongation (GO:0022616)2.76085117
128CENP-A containing nucleosome assembly (GO:0034080)2.75919772
129signal transduction involved in DNA integrity checkpoint (GO:0072401)2.75598515
130RNA capping (GO:0036260)2.75429742
1317-methylguanosine RNA capping (GO:0009452)2.75429742
132translation (GO:0006412)2.74458747
133establishment of protein localization to mitochondrion (GO:0072655)2.74417276
134translational initiation (GO:0006413)2.74399289
135ubiquinone metabolic process (GO:0006743)2.73433869
136DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.73291402
137positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.73081979
138ATP biosynthetic process (GO:0006754)2.72326401
139chaperone-mediated protein transport (GO:0072321)2.72211311
140mitochondrial respiratory chain complex assembly (GO:0033108)2.72195658
141termination of RNA polymerase III transcription (GO:0006386)2.72067520
142transcription elongation from RNA polymerase III promoter (GO:0006385)2.72067520
143aspartate family amino acid metabolic process (GO:0009066)2.71728500
144pteridine-containing compound biosynthetic process (GO:0042559)2.70123119
145tetrahydrofolate metabolic process (GO:0046653)2.69988997
146transcription elongation from RNA polymerase I promoter (GO:0006362)2.68911712
147signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.68306254
148intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.68306254
149protein targeting to mitochondrion (GO:0006626)2.67229027

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.60903202
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.44082835
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.26762686
4* EST1_17652178_ChIP-ChIP_JURKAT_Human3.62078977
5* GABP_17652178_ChIP-ChIP_JURKAT_Human3.58727815
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.50933991
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.46991654
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.29165166
9* ETS1_20019798_ChIP-Seq_JURKAT_Human3.17967533
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.17839242
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.13008591
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.95629378
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.93468334
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.84612743
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.81908869
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.67478707
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.56961769
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.54806086
19* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.43206723
20CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.36791320
21* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.36582543
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.30660978
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.27084835
24* VDR_23849224_ChIP-Seq_CD4+_Human2.26314343
25ZNF274_21170338_ChIP-Seq_K562_Hela2.26160915
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.23599469
27VDR_22108803_ChIP-Seq_LS180_Human2.22090768
28XRN2_22483619_ChIP-Seq_HELA_Human2.18651358
29* DCP1A_22483619_ChIP-Seq_HELA_Human2.15552732
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.15197226
31CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.14168192
32* PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.08061589
33EGR1_23403033_ChIP-Seq_LIVER_Mouse2.05952662
34SRF_21415370_ChIP-Seq_HL-1_Mouse2.01553277
35* FOXP3_21729870_ChIP-Seq_TREG_Human2.00386397
36AR_21909140_ChIP-Seq_LNCAP_Human2.00020162
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.95851841
38RBPJ_22232070_ChIP-Seq_NCS_Mouse1.91736441
39ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.90159023
40PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.89511008
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.88588231
42FOXM1_23109430_ChIP-Seq_U2OS_Human1.86299530
43EWS_26573619_Chip-Seq_HEK293_Human1.86169570
44* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.86029212
45FUS_26573619_Chip-Seq_HEK293_Human1.83551109
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.82876754
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82169797
48* GABP_19822575_ChIP-Seq_HepG2_Human1.79059285
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.75926109
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.75238162
51MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.73471451
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.71869371
53TTF2_22483619_ChIP-Seq_HELA_Human1.70878257
54RXR_22158963_ChIP-Seq_LIVER_Mouse1.68895928
55ELK1_19687146_ChIP-ChIP_HELA_Human1.67339283
56* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.67024398
57PPARA_22158963_ChIP-Seq_LIVER_Mouse1.62267556
58POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.62227878
59ELF1_17652178_ChIP-ChIP_JURKAT_Human1.58458176
60YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55402346
61* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.54194084
62IGF1R_20145208_ChIP-Seq_DFB_Human1.53378715
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.51564105
64POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48778586
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.44019933
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.40801690
67ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.39265613
68STAT3_1855785_ChIP-Seq_MESCs_Mouse1.37791957
69ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35844224
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.35703106
71KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.27498847
72ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.27420092
73TAF15_26573619_Chip-Seq_HEK293_Human1.26730640
74SOX2_18555785_ChIP-Seq_MESCs_Mouse1.24230420
75P300_19829295_ChIP-Seq_ESCs_Human1.22316121
76HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20577382
77EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20547478
78SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.19394767
79BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.19096115
80POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18992276
81NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.18766725
82MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18557378
83KDM5A_27292631_Chip-Seq_BREAST_Human1.17043044
84FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.16245670
85HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.15307325
86ELK1_22589737_ChIP-Seq_MCF10A_Human1.11252382
87NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.11215752
88* TP53_22573176_ChIP-Seq_HFKS_Human1.11203498
89SOX17_20123909_ChIP-Seq_XEN_Mouse1.10229162
90* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.08694205
91ZFP57_27257070_Chip-Seq_ESCs_Mouse1.07926933
92LXR_22158963_ChIP-Seq_LIVER_Mouse1.07248037
93MYC_18940864_ChIP-ChIP_HL60_Human1.06755321
94* E2F1_21310950_ChIP-Seq_MCF-7_Human1.06018715
95NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.05726447
96KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05720597
97* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04331974
98CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03235374
99IRF1_19129219_ChIP-ChIP_H3396_Human1.03048606
100KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.02861651
101KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.02861651
102KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.02861651
103NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02446650
104* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.02125324
105FOXA1_25329375_ChIP-Seq_VCAP_Human0.99674940
106FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99674940
107TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98407057
108CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97447819
109GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96761674
110* SOX2_16153702_ChIP-ChIP_HESCs_Human0.96144290
111* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95133511
112* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.94795566
113CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94226190
114NANOG_19829295_ChIP-Seq_ESCs_Human0.93901658
115SOX2_19829295_ChIP-Seq_ESCs_Human0.93901658
116CTBP2_25329375_ChIP-Seq_LNCAP_Human0.91516823
117TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91432392
118NANOG_16153702_ChIP-ChIP_HESCs_Human0.91305880
119NFE2_27457419_Chip-Seq_LIVER_Mouse0.90843634
120KLF4_18555785_ChIP-Seq_MESCs_Mouse0.89407111
121EZH2_27294783_Chip-Seq_NPCs_Mouse0.89081807
122SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.88572469
123SALL1_21062744_ChIP-ChIP_HESCs_Human0.87841485
124* NCOR_22424771_ChIP-Seq_293T_Human0.87155165
125* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.86657879
126ER_23166858_ChIP-Seq_MCF-7_Human0.85180167
127FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.84673392
128* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.83994564
129SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.83785050
130FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.83545977
131SUZ12_27294783_Chip-Seq_NPCs_Mouse0.82739797
132AR_20517297_ChIP-Seq_VCAP_Human0.82056508
133E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.81742628
134CBP_20019798_ChIP-Seq_JUKART_Human0.80356459
135IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.80356459
136RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.79871460
137ESR1_15608294_ChIP-ChIP_MCF-7_Human0.79052641
138NANOG_21062744_ChIP-ChIP_HESCs_Human0.79018827
139ERG_20517297_ChIP-Seq_VCAP_Human0.78901228

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis6.22117615
2MP0005360_urolithiasis4.51401429
3MP0002139_abnormal_hepatobiliary_system4.19262227
4MP0003693_abnormal_embryo_hatching3.76542277
5MP0005085_abnormal_gallbladder_physiolo3.56815097
6MP0006292_abnormal_olfactory_placode3.07899991
7MP0005365_abnormal_bile_salt3.06511022
8MP0004957_abnormal_blastocyst_morpholog3.02988325
9MP0008875_abnormal_xenobiotic_pharmacok2.90377119
10MP0003718_maternal_effect2.87227990
11MP0006036_abnormal_mitochondrial_physio2.79251439
12MP0010094_abnormal_chromosome_stability2.60550036
13MP0002102_abnormal_ear_morphology2.36005123
14MP0002163_abnormal_gland_morphology2.35134097
15MP0006072_abnormal_retinal_apoptosis2.31320169
16MP0008058_abnormal_DNA_repair2.22380516
17MP0005332_abnormal_amino_acid2.17891160
18MP0003111_abnormal_nucleus_morphology2.16371064
19MP0006035_abnormal_mitochondrial_morpho2.14537000
20MP0008789_abnormal_olfactory_epithelium2.08261173
21MP0003123_paternal_imprinting2.06584447
22MP0003186_abnormal_redox_activity2.03741957
23MP0003077_abnormal_cell_cycle2.00500800
24MP0001764_abnormal_homeostasis1.99603783
25MP0003646_muscle_fatigue1.95136173
26MP0009697_abnormal_copulation1.92451929
27MP0003195_calcinosis1.91846287
28MP0000372_irregular_coat_pigmentation1.86285595
29MP0008932_abnormal_embryonic_tissue1.81384175
30MP0009840_abnormal_foam_cell1.79888380
31MP0001984_abnormal_olfaction1.78873364
32MP0008057_abnormal_DNA_replication1.78713401
33MP0005266_abnormal_metabolism1.71803195
34MP0005379_endocrine/exocrine_gland_phen1.71460241
35MP0005084_abnormal_gallbladder_morpholo1.70103408
36MP0002837_dystrophic_cardiac_calcinosis1.65556011
37MP0009379_abnormal_foot_pigmentation1.65535631
38MP0001730_embryonic_growth_arrest1.61154339
39MP0001529_abnormal_vocalization1.59269637
40MP0004084_abnormal_cardiac_muscle1.52929413
41MP0008877_abnormal_DNA_methylation1.52675307
42MP0001293_anophthalmia1.51506363
43MP0002638_abnormal_pupillary_reflex1.50540595
44MP0010329_abnormal_lipoprotein_level1.50212322
45MP0005253_abnormal_eye_physiology1.50110192
46MP0002277_abnormal_respiratory_mucosa1.44006825
47MP0005394_taste/olfaction_phenotype1.42118811
48MP0005499_abnormal_olfactory_system1.42118811
49MP0005551_abnormal_eye_electrophysiolog1.38775941
50MP0000631_abnormal_neuroendocrine_gland1.36476123
51MP0004019_abnormal_vitamin_homeostasis1.30642661
52MP0003786_premature_aging1.30589488
53MP0002234_abnormal_pharynx_morphology1.28891189
54MP0003950_abnormal_plasma_membrane1.28512639
55MP0001666_abnormal_nutrient_absorption1.26293140
56MP0003787_abnormal_imprinting1.26291320
57MP0003221_abnormal_cardiomyocyte_apopto1.26019679
58MP0005075_abnormal_melanosome_morpholog1.25004185
59MP0005330_cardiomyopathy1.24760532
60MP0008007_abnormal_cellular_replicative1.22015139
61MP0005408_hypopigmentation1.21672399
62MP0000569_abnormal_digit_pigmentation1.19278537
63MP0004036_abnormal_muscle_relaxation1.14262540
64MP0005319_abnormal_enzyme/_coenzyme1.13065437
65MP0008995_early_reproductive_senescence1.11641034
66MP0003011_delayed_dark_adaptation1.11479583
67MP0004133_heterotaxia1.10939439
68MP0004215_abnormal_myocardial_fiber1.10165126
69MP0005083_abnormal_biliary_tract1.09587487
70MP0005646_abnormal_pituitary_gland1.09084531
71MP0005376_homeostasis/metabolism_phenot1.08989150
72MP0003252_abnormal_bile_duct1.08707065
73MP0004147_increased_porphyrin_level1.08099385
74MP0003880_abnormal_central_pattern1.07626428
75MP0005395_other_phenotype1.07156728
76MP0005645_abnormal_hypothalamus_physiol1.06781485
77MP0002160_abnormal_reproductive_system1.06352172
78MP0004043_abnormal_pH_regulation1.05908343
79MP0001485_abnormal_pinna_reflex1.03979205
80MP0003941_abnormal_skin_development1.03410863
81MP0005451_abnormal_body_composition1.02524511
82MP0002736_abnormal_nociception_after1.01911968
83MP0002095_abnormal_skin_pigmentation1.01434863
84MP0005380_embryogenesis_phenotype0.99298036
85MP0001672_abnormal_embryogenesis/_devel0.99298036
86MP0002269_muscular_atrophy0.98985817
87MP0003698_abnormal_male_reproductive0.98325227
88MP0001697_abnormal_embryo_size0.97541112
89MP0003567_abnormal_fetal_cardiomyocyte0.97134676
90MP0002210_abnormal_sex_determination0.96912173
91MP0002233_abnormal_nose_morphology0.96252861
92MP0005174_abnormal_tail_pigmentation0.95220104
93MP0004145_abnormal_muscle_electrophysio0.94575338
94MP0002332_abnormal_exercise_endurance0.94221480
95MP0004142_abnormal_muscle_tone0.94162275
96MP0002876_abnormal_thyroid_physiology0.93922963
97MP0001929_abnormal_gametogenesis0.92428285
98MP0002127_abnormal_cardiovascular_syste0.92229733
99MP0006276_abnormal_autonomic_nervous0.91843852
100MP0000609_abnormal_liver_physiology0.91703497
101MP0005636_abnormal_mineral_homeostasis0.91524135
102MP0005584_abnormal_enzyme/coenzyme_acti0.90634090
103MP0003315_abnormal_perineum_morphology0.90610187
104MP0001188_hyperpigmentation0.88899446
105MP0002118_abnormal_lipid_homeostasis0.88302429
106MP0001145_abnormal_male_reproductive0.86770425
107MP0005389_reproductive_system_phenotype0.85353989
108MP0002080_prenatal_lethality0.84871771
109MP0003984_embryonic_growth_retardation0.83901420
110MP0002088_abnormal_embryonic_growth/wei0.83833987
111MP0003656_abnormal_erythrocyte_physiolo0.83794101
112MP0009046_muscle_twitch0.82839348
113MP0003890_abnormal_embryonic-extraembry0.82511833
114MP0000350_abnormal_cell_proliferation0.82490674
115MP0000358_abnormal_cell_content/0.82024739
116MP0001727_abnormal_embryo_implantation0.81369991
117MP0006138_congestive_heart_failure0.80488640
118MP0001661_extended_life_span0.80409937
119MP0000049_abnormal_middle_ear0.80149307
120MP0000653_abnormal_sex_gland0.79745543
121MP0002751_abnormal_autonomic_nervous0.79471835
122MP0000749_muscle_degeneration0.78983471
123MP0003937_abnormal_limbs/digits/tail_de0.77319678
124MP0001119_abnormal_female_reproductive0.77256317
125MP0004233_abnormal_muscle_weight0.77194035
126MP0009643_abnormal_urine_homeostasis0.76265065
127MP0001905_abnormal_dopamine_level0.76034066
128MP0005391_vision/eye_phenotype0.75573688
129MP0002138_abnormal_hepatobiliary_system0.74773420
130MP0008872_abnormal_physiological_respon0.74743186
131MP0000750_abnormal_muscle_regeneration0.73634021
132MP0001968_abnormal_touch/_nociception0.73545764
133MP0002132_abnormal_respiratory_system0.72924967
134MP0005410_abnormal_fertilization0.72602507
135MP0005195_abnormal_posterior_eye0.70402496
136MP0002653_abnormal_ependyma_morphology0.69023698
137MP0009672_abnormal_birth_weight0.68406509
138MP0003136_yellow_coat_color0.67700722
139MP0003121_genomic_imprinting0.66909825
140MP0003119_abnormal_digestive_system0.65617070
141MP0000598_abnormal_liver_morphology0.65431344
142MP0002938_white_spotting0.64633548
143MP0002272_abnormal_nervous_system0.64178604
144MP0005671_abnormal_response_to0.63707409
145MP0001544_abnormal_cardiovascular_syste0.63699301
146MP0005385_cardiovascular_system_phenoty0.63699301
147MP0002085_abnormal_embryonic_tissue0.62676154
148MP0001286_abnormal_eye_development0.62644572
149MP0001919_abnormal_reproductive_system0.61808090
150MP0005647_abnormal_sex_gland0.61607912

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolysis (HP:0004366)4.74380923
2Increased serum pyruvate (HP:0003542)4.74380923
3Acute necrotizing encephalopathy (HP:0006965)4.49575331
4Acute encephalopathy (HP:0006846)4.34906312
5Hepatic necrosis (HP:0002605)4.28715998
6Abnormal mitochondria in muscle tissue (HP:0008316)4.24977940
7Hypobetalipoproteinemia (HP:0003563)4.23719436
8Cerebral edema (HP:0002181)4.20703727
9Hepatocellular necrosis (HP:0001404)4.13000456
10Mitochondrial inheritance (HP:0001427)3.99969029
11Increased CSF lactate (HP:0002490)3.92140304
12Hyperglycinemia (HP:0002154)3.80886492
13Abnormality of aromatic amino acid family metabolism (HP:0004338)3.68196213
14Progressive macrocephaly (HP:0004481)3.59909765
15Intrahepatic cholestasis (HP:0001406)3.53363013
16Hyperglycinuria (HP:0003108)3.46987618
17Abnormality of serine family amino acid metabolism (HP:0010894)3.39693647
18Abnormality of glycine metabolism (HP:0010895)3.39693647
19Increased serum lactate (HP:0002151)3.36016690
20Pancreatic cysts (HP:0001737)3.32349678
21Lethargy (HP:0001254)3.31852851
22Lactic acidosis (HP:0003128)3.26546130
23Pancreatic fibrosis (HP:0100732)3.22195238
24Hyperammonemia (HP:0001987)3.18205740
25Abnormality of monocarboxylic acid metabolism (HP:0010996)3.14770572
26Abnormality of midbrain morphology (HP:0002418)3.12451515
27Molar tooth sign on MRI (HP:0002419)3.12451515
28Birth length less than 3rd percentile (HP:0003561)3.09781318
29Lipid accumulation in hepatocytes (HP:0006561)3.08193733
30CNS demyelination (HP:0007305)2.99539435
31Increased hepatocellular lipid droplets (HP:0006565)2.97804825
32Abnormality of serum amino acid levels (HP:0003112)2.96453888
33True hermaphroditism (HP:0010459)2.94006682
34Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.92941965
35Hypoglycemic coma (HP:0001325)2.91853816
36Abnormality of dicarboxylic acid metabolism (HP:0010995)2.87367821
37Dicarboxylic aciduria (HP:0003215)2.87367821
38Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.86379095
39Decreased activity of mitochondrial respiratory chain (HP:0008972)2.86379095
40Abnormal respiratory motile cilium physiology (HP:0012261)2.80075961
41Abnormal respiratory epithelium morphology (HP:0012253)2.77958996
42Abnormal respiratory motile cilium morphology (HP:0005938)2.77958996
43Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.76951178
44Abnormal ciliary motility (HP:0012262)2.76071881
45Breast hypoplasia (HP:0003187)2.74985002
46Medial flaring of the eyebrow (HP:0010747)2.74830747
47Respiratory failure (HP:0002878)2.72016209
48Nephronophthisis (HP:0000090)2.69315736
49Abnormality of methionine metabolism (HP:0010901)2.69141218
50Hypolipoproteinemia (HP:0010981)2.66096924
513-Methylglutaconic aciduria (HP:0003535)2.63431282
52Abnormality of fatty-acid metabolism (HP:0004359)2.63212643
53Absent/shortened dynein arms (HP:0200106)2.61484841
54Dynein arm defect of respiratory motile cilia (HP:0012255)2.61484841
55Exercise intolerance (HP:0003546)2.60960543
56Colon cancer (HP:0003003)2.59209277
57Increased intramyocellular lipid droplets (HP:0012240)2.57034030
58Macrocytic anemia (HP:0001972)2.55997116
59Leukodystrophy (HP:0002415)2.55230663
60Abnormality of aspartate family amino acid metabolism (HP:0010899)2.54919676
61Methylmalonic acidemia (HP:0002912)2.51536895
62Abnormality of pyrimidine metabolism (HP:0004353)2.50404383
63Rhinitis (HP:0012384)2.50214951
64Increased muscle lipid content (HP:0009058)2.48099265
65Cerebral hypomyelination (HP:0006808)2.46367038
66Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.45404204
67Exertional dyspnea (HP:0002875)2.40548968
68Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.36931302
69Abnormality of urine glucose concentration (HP:0011016)2.34824174
70Glycosuria (HP:0003076)2.34824174
71Xanthomatosis (HP:0000991)2.33290812
72Oral leukoplakia (HP:0002745)2.31541588
73Palpitations (HP:0001962)2.29433619
74Prolonged partial thromboplastin time (HP:0003645)2.26163451
75Rhabdomyolysis (HP:0003201)2.24670840
76Abnormality of alanine metabolism (HP:0010916)2.24417030
77Hyperalaninemia (HP:0003348)2.24417030
78Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.24417030
79Metabolic acidosis (HP:0001942)2.24110625
80Renal Fanconi syndrome (HP:0001994)2.24109065
81Abnormality of renal resorption (HP:0011038)2.22457905
82Abnormality of sulfur amino acid metabolism (HP:0004339)2.22160916
83Multiple enchondromatosis (HP:0005701)2.22028463
84Abnormality of cells of the erythroid lineage (HP:0012130)2.21366769
85Cholecystitis (HP:0001082)2.21153335
86Abnormal gallbladder physiology (HP:0012438)2.21153335
87Stenosis of the external auditory canal (HP:0000402)2.20583005
88Generalized aminoaciduria (HP:0002909)2.20387503
89Ketosis (HP:0001946)2.20375936
90Aplastic anemia (HP:0001915)2.19588580
91Type I transferrin isoform profile (HP:0003642)2.16678720
92Hyperlipoproteinemia (HP:0010980)2.16494727
93Vomiting (HP:0002013)2.13777841
94Meckel diverticulum (HP:0002245)2.13492272
95Aplasia/Hypoplasia of the uvula (HP:0010293)2.12717220
96Microvesicular hepatic steatosis (HP:0001414)2.12129666
97Congenital primary aphakia (HP:0007707)2.11685040
98Emotional lability (HP:0000712)2.11663648
99Abnormality of the renal medulla (HP:0100957)2.11488236
100Fat malabsorption (HP:0002630)2.11228999
101Carpal bone hypoplasia (HP:0001498)2.10903562
102Nausea (HP:0002018)2.10641834
103Abnormality of the ileum (HP:0001549)2.10477824
104Proximal tubulopathy (HP:0000114)2.07797850
105Ragged-red muscle fibers (HP:0003200)2.07564406
106Optic disc pallor (HP:0000543)2.04913894
107Sclerocornea (HP:0000647)2.04507168
108Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.03430093
109Abnormality of chromosome stability (HP:0003220)2.02397950
110Gait imbalance (HP:0002141)2.01478537
111Progressive external ophthalmoplegia (HP:0000590)2.01041333
112Deep venous thrombosis (HP:0002625)2.01038517
113Delayed CNS myelination (HP:0002188)1.99522575
114Nephrogenic diabetes insipidus (HP:0009806)1.99170797
115Abnormal number of erythroid precursors (HP:0012131)1.98950617
116Intestinal atresia (HP:0011100)1.98761464
117Abnormality of the renal cortex (HP:0011035)1.97692070
118Methylmalonic aciduria (HP:0012120)1.97290958
119Reticulocytopenia (HP:0001896)1.95018976
120Megaloblastic anemia (HP:0001889)1.90258637
121Aplasia/Hypoplasia of the tongue (HP:0010295)1.89884878
122Male pseudohermaphroditism (HP:0000037)1.88899112
123Cystic liver disease (HP:0006706)1.88673658
124Renal cortical cysts (HP:0000803)1.87251313
125Anencephaly (HP:0002323)1.86274677
126Absent thumb (HP:0009777)1.85701912
127Bronchiectasis (HP:0002110)1.85306604
128Chronic bronchitis (HP:0004469)1.84696988
129Ileus (HP:0002595)1.84015612
130Gliosis (HP:0002171)1.83241471
131Abnormal protein glycosylation (HP:0012346)1.82816832
132Abnormal glycosylation (HP:0012345)1.82816832
133Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.82816832
134Abnormal protein N-linked glycosylation (HP:0012347)1.82816832
135Absent rod-and cone-mediated responses on ERG (HP:0007688)1.82741642
136Reduced antithrombin III activity (HP:0001976)1.82187163
137Chromsome breakage (HP:0040012)1.81527154
138Abnormality of the labia minora (HP:0012880)1.81056836
139Respiratory difficulties (HP:0002880)1.80891886
140Myoglobinuria (HP:0002913)1.80784288
141Abnormality of the preputium (HP:0100587)1.79911315
142Abnormality of the anterior horn cell (HP:0006802)1.79882403
143Degeneration of anterior horn cells (HP:0002398)1.79882403
144Genital tract atresia (HP:0001827)1.79422309
145Gout (HP:0001997)1.77955313
146Steatorrhea (HP:0002570)1.77786045
147Impulsivity (HP:0100710)1.77591486
148Triphalangeal thumb (HP:0001199)1.76799549
149Median cleft lip (HP:0000161)1.76129804
150Abnormal hemoglobin (HP:0011902)1.76041836
151Hyperphosphaturia (HP:0003109)1.75008946
152Cleft eyelid (HP:0000625)1.73078527
153Vaginal atresia (HP:0000148)1.73049083
154Supernumerary spleens (HP:0009799)1.72565251
155Opisthotonus (HP:0002179)1.72385315
156Spastic paraparesis (HP:0002313)1.71535167
157Abnormal rod and cone electroretinograms (HP:0008323)1.70786744

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.75846349
2WEE13.97897444
3VRK23.31919193
4EIF2AK13.07654732
5BCKDK3.07212833
6MAP4K22.86980583
7PDK32.85498864
8PDK42.85498864
9SRPK12.73239306
10NEK12.71434808
11STK162.68375906
12TSSK62.63290438
13NUAK12.53163023
14PNCK2.41523079
15NME22.37455211
16CDC72.13003136
17AKT32.06384168
18TTK1.94285196
19PDK21.83248827
20TLK11.83118026
21PBK1.80077040
22MST41.75733354
23BRSK21.70885127
24PLK41.70012863
25EIF2AK31.69694897
26VRK11.64877505
27PLK31.63433015
28EPHA21.62752469
29LMTK21.59598770
30NME11.59227620
31TAF11.58389274
32PLK11.56405133
33STK38L1.55505678
34TRIM281.54935856
35CCNB11.45755123
36OBSCN1.38304878
37DYRK31.37773825
38STK391.37029004
39AURKA1.30053729
40PIK3CG1.29362184
41AURKB1.28069489
42TNIK1.26587219
43MAP3K41.23701635
44ACVR1B1.22250082
45ZAK1.20653730
46FRK1.15447690
47ADRBK21.11192827
48GRK11.09210847
49MKNK11.08999983
50MAP3K121.04525778
51NEK20.99587699
52ERBB40.99438051
53PINK10.98583538
54RPS6KB20.98518004
55BRAF0.95942374
56BRSK10.95718608
57CDK80.95413039
58BCR0.93259456
59MAP2K70.91118037
60TIE10.90838528
61LIMK10.89741718
62TESK20.89040442
63MYLK0.86669763
64MKNK20.83994184
65CHEK20.82952672
66OXSR10.81715690
67CSNK2A20.81555347
68PASK0.80991807
69CDK70.77858545
70CSNK2A10.75901674
71WNK40.74531685
72MAP3K80.71523170
73CHEK10.70760851
74CSNK1G20.68842913
75PLK20.68822078
76STK240.68068827
77TEC0.67422654
78ERBB30.67352515
79ATR0.66571355
80MET0.66134149
81MAPK130.66035525
82DYRK20.65151043
83ABL20.64375820
84TAOK30.62631699
85STK30.62001089
86INSRR0.61621134
87PIK3CA0.60585334
88STK40.58790936
89CASK0.58778280
90TGFBR10.58191941
91CSNK1E0.57125802
92MAPKAPK50.56403538
93RPS6KA40.55350989
94MELK0.55262597
95BMPR1B0.55192514
96ATM0.52272192
97CDK30.50823271
98FLT30.50205399
99CSNK1A1L0.49647145
100WNK30.47726772
101PAK30.47046434
102CSNK1G30.45928246
103CAMK2G0.44564281
104PAK10.44401572
105PHKG10.43078290
106PHKG20.43078290
107KDR0.42394828
108PRKCQ0.42004227
109CDK20.41817187
110CAMK2B0.40647013
111MST1R0.40279676
112RPS6KA50.40059188
113CDK10.39743718
114CAMK2D0.39312799
115TESK10.37425029
116MINK10.36418844
117DAPK10.35774258
118PRKCE0.35490190
119CDK40.35285263
120TXK0.35085845
121MARK30.34483845
122EIF2AK20.32562840
123MAPKAPK30.31582111
124ARAF0.31294850
125CDK90.31025803
126SCYL20.26024748
127AKT20.24719810
128PRKCI0.23625058
129CSNK1G10.23039361
130LATS20.22174755
131PRKACA0.19479973
132PRKCG0.18886557
133PRKACB0.17839231
134IRAK30.17692619
135PRKDC0.17267124
136PAK40.17113079
137MAPK110.16069262
138CDK190.15246473

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030502.88538829
2Oxidative phosphorylation_Homo sapiens_hsa001902.54307006
3Ribosome_Homo sapiens_hsa030102.48726542
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.43627539
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.36704747
6Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.26286721
7Parkinsons disease_Homo sapiens_hsa050122.23718772
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.19214175
9RNA polymerase_Homo sapiens_hsa030202.18981761
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.08400479
11Mismatch repair_Homo sapiens_hsa034302.06311129
12DNA replication_Homo sapiens_hsa030302.00396181
13Propanoate metabolism_Homo sapiens_hsa006401.97833147
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.95134855
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.89864209
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.88957291
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.83890084
18Pyruvate metabolism_Homo sapiens_hsa006201.83668915
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.83590904
20Carbon metabolism_Homo sapiens_hsa012001.78262232
21One carbon pool by folate_Homo sapiens_hsa006701.74789890
22Butanoate metabolism_Homo sapiens_hsa006501.74095856
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.70440135
24Huntingtons disease_Homo sapiens_hsa050161.68310303
25Vitamin B6 metabolism_Homo sapiens_hsa007501.68063034
26Fatty acid degradation_Homo sapiens_hsa000711.65371448
27Biosynthesis of amino acids_Homo sapiens_hsa012301.62393922
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.60908618
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.60798305
30Folate biosynthesis_Homo sapiens_hsa007901.56977429
31RNA transport_Homo sapiens_hsa030131.56670113
32Fatty acid elongation_Homo sapiens_hsa000621.51884462
33Pyrimidine metabolism_Homo sapiens_hsa002401.50949767
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.48688028
35Spliceosome_Homo sapiens_hsa030401.47223795
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.43482587
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.40955751
38Sulfur metabolism_Homo sapiens_hsa009201.39290249
39Alzheimers disease_Homo sapiens_hsa050101.35945766
40Tryptophan metabolism_Homo sapiens_hsa003801.35679186
41Nucleotide excision repair_Homo sapiens_hsa034201.35644166
42Peroxisome_Homo sapiens_hsa041461.34583639
43Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.33992734
44Arginine biosynthesis_Homo sapiens_hsa002201.33665652
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.33121587
46Homologous recombination_Homo sapiens_hsa034401.31776794
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.29218354
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.26691778
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.23710799
50Glutathione metabolism_Homo sapiens_hsa004801.22294387
51Fatty acid metabolism_Homo sapiens_hsa012121.19095464
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.18549842
53Nitrogen metabolism_Homo sapiens_hsa009101.16590179
54Chemical carcinogenesis_Homo sapiens_hsa052041.11896727
55Steroid biosynthesis_Homo sapiens_hsa001001.07540515
56Phototransduction_Homo sapiens_hsa047441.07455894
57Pentose phosphate pathway_Homo sapiens_hsa000301.07236813
58Pentose and glucuronate interconversions_Homo sapiens_hsa000401.07225621
59Selenocompound metabolism_Homo sapiens_hsa004501.05546489
60Arginine and proline metabolism_Homo sapiens_hsa003301.05126352
61beta-Alanine metabolism_Homo sapiens_hsa004101.04807231
62Tyrosine metabolism_Homo sapiens_hsa003501.03749142
63Cyanoamino acid metabolism_Homo sapiens_hsa004601.02604773
64Histidine metabolism_Homo sapiens_hsa003401.02195545
65Sulfur relay system_Homo sapiens_hsa041221.01431767
66Phenylalanine metabolism_Homo sapiens_hsa003601.00543743
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00100102
68Basal transcription factors_Homo sapiens_hsa030220.98449252
69Base excision repair_Homo sapiens_hsa034100.97033842
70Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95145032
71Protein export_Homo sapiens_hsa030600.92189532
72Purine metabolism_Homo sapiens_hsa002300.89593624
73Retinol metabolism_Homo sapiens_hsa008300.88690079
74Metabolic pathways_Homo sapiens_hsa011000.87817561
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.86270788
76Fructose and mannose metabolism_Homo sapiens_hsa000510.84438391
77RNA degradation_Homo sapiens_hsa030180.78975867
78Fanconi anemia pathway_Homo sapiens_hsa034600.78836478
79Cardiac muscle contraction_Homo sapiens_hsa042600.78456366
80Non-homologous end-joining_Homo sapiens_hsa034500.74004880
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71583049
82Asthma_Homo sapiens_hsa053100.71299802
83Collecting duct acid secretion_Homo sapiens_hsa049660.69565399
84Fat digestion and absorption_Homo sapiens_hsa049750.68945802
85PPAR signaling pathway_Homo sapiens_hsa033200.68495209
86Complement and coagulation cascades_Homo sapiens_hsa046100.68394053
87Primary immunodeficiency_Homo sapiens_hsa053400.67981456
88Cell cycle_Homo sapiens_hsa041100.66978721
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58529962
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56339370
91Type I diabetes mellitus_Homo sapiens_hsa049400.56118075
92Starch and sucrose metabolism_Homo sapiens_hsa005000.55494034
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55219325
94Olfactory transduction_Homo sapiens_hsa047400.51765409
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51110085
96Oocyte meiosis_Homo sapiens_hsa041140.49830593
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49805762
98Allograft rejection_Homo sapiens_hsa053300.49217423
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.47476530
100Vitamin digestion and absorption_Homo sapiens_hsa049770.46996628
101Autoimmune thyroid disease_Homo sapiens_hsa053200.45879962
102Galactose metabolism_Homo sapiens_hsa000520.45094089
103Systemic lupus erythematosus_Homo sapiens_hsa053220.44811035
104mRNA surveillance pathway_Homo sapiens_hsa030150.43110220
105Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41550623
106Intestinal immune network for IgA production_Homo sapiens_hsa046720.40880490
107Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38481667
108Linoleic acid metabolism_Homo sapiens_hsa005910.38072026
109p53 signaling pathway_Homo sapiens_hsa041150.35990102
110Graft-versus-host disease_Homo sapiens_hsa053320.35833294
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34691220
112Glycerolipid metabolism_Homo sapiens_hsa005610.30794438
113Epstein-Barr virus infection_Homo sapiens_hsa051690.28171778
114Caffeine metabolism_Homo sapiens_hsa002320.26857952
115Ether lipid metabolism_Homo sapiens_hsa005650.25474076
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24685719
117Regulation of autophagy_Homo sapiens_hsa041400.24635283
118Bile secretion_Homo sapiens_hsa049760.24618649
119Arachidonic acid metabolism_Homo sapiens_hsa005900.22961734
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.19362614

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