ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	glycosphingolipid biosynthetic process (GO:0006688)	6.72688524
2	pyrimidine nucleobase catabolic process (GO:0006208)	5.45903336
3	regulation of B cell receptor signaling pathway (GO:0050855)	4.75915388
4	glycosylceramide metabolic process (GO:0006677)	4.71150541
5	positive regulation of defense response to virus by host (GO:0002230)	4.59182509
6	negative regulation of telomere maintenance (GO:0032205)	4.55846158
7	positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)	4.33660583
8	positive regulation of cell cycle G2/M phase transition (GO:1902751)	4.33660583
9	UV protection (GO:0009650)	4.25635017
10	nucleobase catabolic process (GO:0046113)	4.24127662
11	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO	4.18362353
12	regulation of telomere maintenance (GO:0032204)	4.17407482
13	hepatocyte apoptotic process (GO:0097284)	4.16013331
14	C4-dicarboxylate transport (GO:0015740)	4.13840292
15	regulation of nuclear cell cycle DNA replication (GO:0033262)	4.09875333
16	bicarbonate transport (GO:0015701)	4.03456589
17	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	3.91835162
18	isotype switching (GO:0045190)	3.91835162
19	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	3.91835162
20	neural tube formation (GO:0001841)	3.91106747
21	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.86171457
22	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.86171457
23	positive regulation of T-helper 1 type immune response (GO:0002827)	3.84847609
24	corticosteroid receptor signaling pathway (GO:0031958)	3.81509223
25	behavioral response to nicotine (GO:0035095)	3.75192672
26	lymphoid progenitor cell differentiation (GO:0002320)	3.73635425
27	negative regulation of B cell proliferation (GO:0030889)	3.72324242
28	rRNA catabolic process (GO:0016075)	3.71031709
29	defense response to protozoan (GO:0042832)	3.56436444
30	glucocorticoid receptor signaling pathway (GO:0042921)	3.48830125
31	negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)	3.47699804
32	ribonucleoprotein complex disassembly (GO:0032988)	3.43393578
33	regulation of intracellular pH (GO:0051453)	3.43246307
34	epithelial cilium movement (GO:0003351)	3.39969325
35	ether lipid metabolic process (GO:0046485)	3.38608739
36	transepithelial transport (GO:0070633)	3.38463629
37	RNA localization (GO:0006403)	3.35302153
38	one-carbon compound transport (GO:0019755)	3.30825184
39	regulation of cellular pH (GO:0030641)	3.30626325
40	immunoglobulin mediated immune response (GO:0016064)	3.28274632
41	negative regulation of type 2 immune response (GO:0002829)	3.25978543
42	ceramide biosynthetic process (GO:0046513)	3.21134037
43	organelle disassembly (GO:1903008)	3.21020007
44	response to misfolded protein (GO:0051788)	3.15682505
45	DNA deamination (GO:0045006)	3.08650068
46	negative regulation of circadian rhythm (GO:0042754)	3.06155685
47	response to protozoan (GO:0001562)	3.04913450
48	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.02647118
49	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	3.01089112
50	GTP biosynthetic process (GO:0006183)	2.98534919
51	mitotic recombination (GO:0006312)	2.96986817
52	regulation of T-helper 1 type immune response (GO:0002825)	2.95667915
53	pyrimidine nucleoside catabolic process (GO:0046135)	2.93196244
54	regulation of memory T cell differentiation (GO:0043380)	2.91756864
55	regulation of telomere maintenance via telomerase (GO:0032210)	2.90989809
56	regulation of isotype switching to IgG isotypes (GO:0048302)	2.90246328
57	male meiosis I (GO:0007141)	2.89502546
58	somatic diversification of immunoglobulins (GO:0016445)	2.89230473
59	response to pheromone (GO:0019236)	2.88895692
60	negative regulation of protein autophosphorylation (GO:0031953)	2.88472127
61	cytidine deamination (GO:0009972)	2.87980970
62	cytidine metabolic process (GO:0046087)	2.87980970
63	cytidine catabolic process (GO:0006216)	2.87980970
64	regulation of triglyceride catabolic process (GO:0010896)	2.87318998
65	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.85055375
66	fucose catabolic process (GO:0019317)	2.83521941
67	L-fucose metabolic process (GO:0042354)	2.83521941
68	L-fucose catabolic process (GO:0042355)	2.83521941
69	single strand break repair (GO:0000012)	2.82729151
70	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.81255451
71	regulation of B cell differentiation (GO:0045577)	2.80758213
72	positive regulation of endothelial cell apoptotic process (GO:2000353)	2.80634705
73	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.78629155
74	regulation of mitotic spindle checkpoint (GO:1903504)	2.78629155
75	negative regulation of histone acetylation (GO:0035067)	2.77328390
76	positive regulation of interleukin-12 production (GO:0032735)	2.77180861
77	misfolded or incompletely synthesized protein catabolic process (GO:0006515)	2.76162108
78	T cell costimulation (GO:0031295)	2.75570948
79	negative regulation of B cell activation (GO:0050869)	2.73879424
80	purinergic nucleotide receptor signaling pathway (GO:0035590)	2.73129015
81	lymphocyte costimulation (GO:0031294)	2.71719970
82	positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)	2.70855080
83	negative regulation of mast cell activation (GO:0033004)	2.67258685
84	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	2.64328573
85	regulation of isotype switching (GO:0045191)	2.63805265
86	cell wall macromolecule catabolic process (GO:0016998)	2.62024183
87	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.61214760
88	microtubule depolymerization (GO:0007019)	2.60726809
89	interferon-gamma-mediated signaling pathway (GO:0060333)	2.59845016
90	pyrimidine-containing compound catabolic process (GO:0072529)	2.59383184
91	cellular protein catabolic process (GO:0044257)	2.58383473
92	DNA integration (GO:0015074)	2.56052129
93	pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)	2.55787443
94	UMP metabolic process (GO:0046049)	2.55787443
95	pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)	2.55787443
96	UMP biosynthetic process (GO:0006222)	2.55787443
97	regulation of DNA endoreduplication (GO:0032875)	2.55605513
98	regulation of calcium-mediated signaling (GO:0050848)	2.55505056
99	telomere maintenance via semi-conservative replication (GO:0032201)	2.55436404
100	sarcoplasmic reticulum calcium ion transport (GO:0070296)	2.53246227

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.18076139
2	ZNF274_21170338_ChIP-Seq_K562_Hela	4.03547527
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.72469151
4	IKZF1_21737484_ChIP-ChIP_HCT116_Human	3.46517876
5	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	3.34651099
6	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.22945658
7	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.20989337
8	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	3.20230281
9	PCGF2_27294783_Chip-Seq_NPCs_Mouse	3.03701715
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.91554987
11	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.75536880
12	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.60457221
13	VDR_22108803_ChIP-Seq_LS180_Human	2.58639384
14	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	2.51210585
15	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.38070048
16	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.27054736
17	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.07571238
18	TP53_16413492_ChIP-PET_HCT116_Human	2.05785020
19	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	2.00613980
20	FUS_26573619_Chip-Seq_HEK293_Human	2.00461784
21	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.79882049
22	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.75972174
23	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.74103574
24	MYB_26560356_Chip-Seq_TH2_Human	1.72160106
25	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.66169358
26	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.65981612
27	EWS_26573619_Chip-Seq_HEK293_Human	1.63614843
28	VDR_24787735_ChIP-Seq_THP-1_Human	1.62641793
29	ELK1_19687146_ChIP-ChIP_HELA_Human	1.61912797
30	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.58528660
31	CIITA_25753668_ChIP-Seq_RAJI_Human	1.57590779
32	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.57387989
33	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.57042558
34	TP53_22573176_ChIP-Seq_HFKS_Human	1.56393921
35	IGF1R_20145208_ChIP-Seq_DFB_Human	1.56228482
36	GATA3_26560356_Chip-Seq_TH2_Human	1.55454342
37	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.55451450
38	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.54887967
39	IRF8_27001747_Chip-Seq_BMDM_Mouse	1.50238223
40	ER_23166858_ChIP-Seq_MCF-7_Human	1.50080170
41	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.47005986
42	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.46154421
43	STAT1_20625510_ChIP-Seq_HELA_Human	1.39358892
44	VDR_23849224_ChIP-Seq_CD4+_Human	1.38581297
45	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.36822444
46	GBX2_23144817_ChIP-Seq_PC3_Human	1.35590741
47	IRF1_19129219_ChIP-ChIP_H3396_Human	1.33913139
48	MYC_18940864_ChIP-ChIP_HL60_Human	1.33807741
49	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.33068231
50	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.29953029
51	P300_19829295_ChIP-Seq_ESCs_Human	1.27737367
52	GATA3_27048872_Chip-Seq_THYMUS_Human	1.27435950
53	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.26661227
54	SPI1_23547873_ChIP-Seq_NB4_Human	1.26060923
55	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.24649400
56	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.24410509
57	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.20290078
58	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.20218058
59	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.19463389
60	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.18395254
61	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.17456463
62	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.15779341
63	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.14423281
64	TAF15_26573619_Chip-Seq_HEK293_Human	1.14382411
65	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.13972599
66	PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.11998479
67	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	1.11015617
68	TCF4_23295773_ChIP-Seq_U87_Human	1.09916000
69	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.09559418
70	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.07812364
71	FOXP3_21729870_ChIP-Seq_TREG_Human	1.07719494
72	EGR1_19032775_ChIP-ChIP_M12_Human	1.04865121
73	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.04224221
74	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.04176990
75	CBP_20019798_ChIP-Seq_JUKART_Human	1.04176990
76	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.04080262
77	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.03914399
78	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.03800543
79	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.02142947
80	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.00452206
81	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.00389823
82	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.00257750
83	NCOR_22424771_ChIP-Seq_293T_Human	0.99014121
84	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.97930338
85	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.97930338
86	KDM5A_27292631_Chip-Seq_BREAST_Human	0.97809248
87	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.97053298
88	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.96019827
89	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.95421494
90	STAT3_23295773_ChIP-Seq_U87_Human	0.94180186
91	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.93606849
92	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.91873472
93	MYB_26560356_Chip-Seq_TH1_Human	0.91652353
94	GATA3_26560356_Chip-Seq_TH1_Human	0.91281879
95	ERA_21632823_ChIP-Seq_H3396_Human	0.91265330
96	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.91213104
97	RAC3_21632823_ChIP-Seq_H3396_Human	0.90738215
98	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.90123463
99	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.89426481
100	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.88643512

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003950_abnormal_plasma_membrane	6.27755158
2	MP0001835_abnormal_antigen_presentation	5.51373809
3	MP0008057_abnormal_DNA_replication	4.47739559
4	MP0006072_abnormal_retinal_apoptosis	3.85407147
5	MP0005367_renal/urinary_system_phenotyp	3.78804203
6	MP0000516_abnormal_urinary_system	3.78804203
7	MP0006292_abnormal_olfactory_placode	3.62319926
8	MP0002876_abnormal_thyroid_physiology	3.35863807
9	MP0008007_abnormal_cellular_replicative	2.97530369
10	MP0002090_abnormal_vision	2.46125348
11	MP0004043_abnormal_pH_regulation	2.26572854
12	MP0003806_abnormal_nucleotide_metabolis	2.04598516
13	MP0005671_abnormal_response_to	2.02423679
14	MP0006082_CNS_inflammation	1.97601045
15	MP0005365_abnormal_bile_salt	1.84015198
16	MP0001545_abnormal_hematopoietic_system	1.81115217
17	MP0005397_hematopoietic_system_phenotyp	1.81115217
18	MP0005670_abnormal_white_adipose	1.79187785
19	MP0008872_abnormal_physiological_respon	1.66424245
20	MP0005645_abnormal_hypothalamus_physiol	1.64724617
21	MP0002102_abnormal_ear_morphology	1.64143671
22	MP0000685_abnormal_immune_system	1.63618837
23	MP0003656_abnormal_erythrocyte_physiolo	1.60860612
24	MP0001800_abnormal_humoral_immune	1.57557506
25	MP0005551_abnormal_eye_electrophysiolog	1.56851036
26	MP0008058_abnormal_DNA_repair	1.54195313
27	MP0002396_abnormal_hematopoietic_system	1.50941480
28	MP0009785_altered_susceptibility_to	1.48900239
29	MP0005253_abnormal_eye_physiology	1.47590759
30	MP0005266_abnormal_metabolism	1.43091386
31	MP0002723_abnormal_immune_serum	1.34207271
32	MP0003646_muscle_fatigue	1.34162201
33	MP0005000_abnormal_immune_tolerance	1.29526441
34	MP0001542_abnormal_bone_strength	1.28705859
35	MP0002332_abnormal_exercise_endurance	1.28608694
36	MP0000647_abnormal_sebaceous_gland	1.25551201
37	MP0008875_abnormal_xenobiotic_pharmacok	1.18809300
38	MP0002452_abnormal_antigen_presenting	1.10419570
39	MP0005075_abnormal_melanosome_morpholog	1.10399071
40	MP0009745_abnormal_behavioral_response	1.09801458
41	MP0002166_altered_tumor_susceptibility	1.09288454
42	MP0001919_abnormal_reproductive_system	1.05759903
43	MP0004808_abnormal_hematopoietic_stem	1.05108684
44	MP0008877_abnormal_DNA_methylation	1.02259928
45	MP0002420_abnormal_adaptive_immunity	1.02112171
46	MP0000689_abnormal_spleen_morphology	1.01779829
47	MP0006036_abnormal_mitochondrial_physio	0.97712840
48	MP0002398_abnormal_bone_marrow	0.97368141
49	MP0001819_abnormal_immune_cell	0.96801816
50	MP0005025_abnormal_response_to	0.96263148
51	MP0001501_abnormal_sleep_pattern	0.94302380
52	MP0005387_immune_system_phenotype	0.93987466
53	MP0001790_abnormal_immune_system	0.93987466
54	MP0000716_abnormal_immune_system	0.92765850
55	MP0005410_abnormal_fertilization	0.92614334
56	MP0002405_respiratory_system_inflammati	0.92129001
57	MP0004264_abnormal_extraembryonic_tissu	0.89383045
58	MP0003693_abnormal_embryo_hatching	0.88162303
59	MP0002429_abnormal_blood_cell	0.86578766
60	MP0003763_abnormal_thymus_physiology	0.85812950
61	MP0002160_abnormal_reproductive_system	0.84492411
62	MP0010155_abnormal_intestine_physiology	0.84286712
63	MP0000372_irregular_coat_pigmentation	0.84123683
64	MP0005389_reproductive_system_phenotype	0.81430867
65	MP0009764_decreased_sensitivity_to	0.79015641
66	MP0003880_abnormal_central_pattern	0.78853148
67	MP0005535_abnormal_body_temperature	0.78846777
68	MP0001853_heart_inflammation	0.77919927
69	MP0000569_abnormal_digit_pigmentation	0.77605314
70	MP0002419_abnormal_innate_immunity	0.77288490
71	MP0003011_delayed_dark_adaptation	0.76718035
72	MP0004147_increased_porphyrin_level	0.76140592
73	MP0004142_abnormal_muscle_tone	0.76072019
74	MP0004782_abnormal_surfactant_physiolog	0.73931792
75	MP0004381_abnormal_hair_follicle	0.73166377
76	MP0003890_abnormal_embryonic-extraembry	0.72054419
77	MP0003252_abnormal_bile_duct	0.71162559
78	MP0002163_abnormal_gland_morphology	0.70709709
79	MP0002006_tumorigenesis	0.69527261
80	MP0009697_abnormal_copulation	0.68357604
81	MP0006035_abnormal_mitochondrial_morpho	0.68128794
82	MP0002254_reproductive_system_inflammat	0.68101086
83	MP0001486_abnormal_startle_reflex	0.67162680
84	MP0003866_abnormal_defecation	0.66133868
85	MP0002148_abnormal_hypersensitivity_rea	0.65865742
86	MP0001188_hyperpigmentation	0.65425987
87	MP0000604_amyloidosis	0.65082493
88	MP0000490_abnormal_crypts_of	0.64856908
89	MP0005257_abnormal_intraocular_pressure	0.64562082
90	MP0005310_abnormal_salivary_gland	0.64177680
91	MP0002722_abnormal_immune_system	0.62702862
92	MP0002653_abnormal_ependyma_morphology	0.61521899
93	MP0004883_abnormal_blood_vessel	0.61029322
94	MP0003786_premature_aging	0.58558893
95	MP0002138_abnormal_hepatobiliary_system	0.58479797
96	MP0004084_abnormal_cardiac_muscle	0.58111689
97	MP0000703_abnormal_thymus_morphology	0.57743590
98	MP0005376_homeostasis/metabolism_phenot	0.56937782
99	MP0003943_abnormal_hepatobiliary_system	0.56496073
100	MP0005360_urolithiasis	0.56005909

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Concave nail (HP:0001598)	5.48119145
2	Stomatitis (HP:0010280)	5.15180666
3	Metaphyseal dysplasia (HP:0100255)	4.98747513
4	Poor eye contact (HP:0000817)	4.05793722
5	Pancreatic cysts (HP:0001737)	3.75279957
6	Bilateral microphthalmos (HP:0007633)	3.57542243
7	Pancreatic fibrosis (HP:0100732)	3.48141619
8	Gastrointestinal infarctions (HP:0005244)	3.34501147
9	Elevated erythrocyte sedimentation rate (HP:0003565)	3.32058626
10	True hermaphroditism (HP:0010459)	3.28732790
11	Congenital stationary night blindness (HP:0007642)	3.24986749
12	Type 2 muscle fiber atrophy (HP:0003554)	3.23245514
13	Follicular hyperkeratosis (HP:0007502)	3.17065082
14	Abnormality of T cell physiology (HP:0011840)	3.11590779
15	Chronic mucocutaneous candidiasis (HP:0002728)	3.00656614
16	Recurrent cutaneous fungal infections (HP:0011370)	3.00656614
17	Chronic hepatic failure (HP:0100626)	2.96963120
18	Abnormality of the prostate (HP:0008775)	2.94360405
19	Multiple enchondromatosis (HP:0005701)	2.92762468
20	Acute lymphatic leukemia (HP:0006721)	2.92573097
21	Hyperventilation (HP:0002883)	2.89099602
22	Impaired social interactions (HP:0000735)	2.88280929
23	Abnormal social behavior (HP:0012433)	2.88280929
24	Agammaglobulinemia (HP:0004432)	2.87312575
25	Cystic liver disease (HP:0006706)	2.72616142
26	Poor head control (HP:0002421)	2.61941479
27	Blepharitis (HP:0000498)	2.61766337
28	Tubular atrophy (HP:0000092)	2.60855294
29	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.58836227
30	Neuroendocrine neoplasm (HP:0100634)	2.57736073
31	Muscle fiber atrophy (HP:0100295)	2.53830229
32	Polydipsia (HP:0001959)	2.52971838
33	Abnormal drinking behavior (HP:0030082)	2.52971838
34	Abnormality of nail color (HP:0100643)	2.52762722
35	Pachygyria (HP:0001302)	2.47484137
36	Occipital encephalocele (HP:0002085)	2.46747694
37	Focal motor seizures (HP:0011153)	2.45705702
38	Chest pain (HP:0100749)	2.45688706
39	Poor speech (HP:0002465)	2.43230191
40	Neonatal respiratory distress (HP:0002643)	2.41999789
41	Acute hepatic failure (HP:0006554)	2.41383716
42	Recurrent bacterial skin infections (HP:0005406)	2.39221579
43	Patellar aplasia (HP:0006443)	2.36129389
44	Recurrent fungal infections (HP:0002841)	2.35101019
45	Lissencephaly (HP:0001339)	2.34602393
46	Ureteral obstruction (HP:0006000)	2.32922653
47	Recurrent viral infections (HP:0004429)	2.31398253
48	Recurrent skin infections (HP:0001581)	2.30505382
49	Bundle branch block (HP:0011710)	2.29499032
50	Short middle phalanx of the 5th finger (HP:0004220)	2.28709824
51	Severe muscular hypotonia (HP:0006829)	2.28001798
52	Ureteral stenosis (HP:0000071)	2.23162202
53	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.21757969
54	Increased corneal curvature (HP:0100692)	2.18661486
55	Keratoconus (HP:0000563)	2.18661486
56	Tachypnea (HP:0002789)	2.18479888
57	Gangrene (HP:0100758)	2.16558513
58	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.16529640
59	Tetraplegia (HP:0002445)	2.16045461
60	Type II lissencephaly (HP:0007260)	2.14497063
61	Acute myeloid leukemia (HP:0004808)	2.12798970
62	Decreased circulating renin level (HP:0003351)	2.09840511
63	Aplasia/Hypoplasia of the patella (HP:0006498)	2.09348601
64	Gaze-evoked nystagmus (HP:0000640)	2.08478364
65	Cerebellar dysplasia (HP:0007033)	2.07083918
66	Meningitis (HP:0001287)	2.05529499
67	Abnormality of T cells (HP:0002843)	2.03838941
68	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.00789057
69	Hemoptysis (HP:0002105)	2.00449951
70	Vasculitis (HP:0002633)	1.98539498
71	Asplenia (HP:0001746)	1.98334801
72	Nephronophthisis (HP:0000090)	1.98253875
73	Abnormality of the vocal cords (HP:0008777)	1.94825553
74	Attenuation of retinal blood vessels (HP:0007843)	1.93090075
75	Anencephaly (HP:0002323)	1.92125279
76	Cleft eyelid (HP:0000625)	1.90578107
77	IgG deficiency (HP:0004315)	1.90171779
78	Panhypogammaglobulinemia (HP:0003139)	1.88292866
79	Abnormality of the renal cortex (HP:0011035)	1.87766118
80	Tinnitus (HP:0000360)	1.87663480
81	Abnormality of the pleura (HP:0002103)	1.87565698
82	Clubbing of toes (HP:0100760)	1.87482121
83	Sclerocornea (HP:0000647)	1.86792832
84	Large eyes (HP:0001090)	1.86729012
85	Polyuria (HP:0000103)	1.85799235
86	Chronic diarrhea (HP:0002028)	1.85438303
87	Focal seizures (HP:0007359)	1.85230535
88	Abnormality of the preputium (HP:0100587)	1.85026258
89	Abnormality of the pubic bones (HP:0003172)	1.83971451
90	Congenital hepatic fibrosis (HP:0002612)	1.83842565
91	Adenoma sebaceum (HP:0009720)	1.82507799
92	Angiofibromas (HP:0010615)	1.82507799
93	Pulmonary infiltrates (HP:0002113)	1.81455522
94	Nonprogressive disorder (HP:0003680)	1.80460015
95	Abnormality of pyrimidine metabolism (HP:0004353)	1.78879157
96	Increased IgM level (HP:0003496)	1.78123661
97	Mediastinal lymphadenopathy (HP:0100721)	1.75270477
98	Disinhibition (HP:0000734)	1.75261405
99	Spondylolisthesis (HP:0003302)	1.74694618
100	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.74443362

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FLT3	4.97843870
2	ADRBK2	3.61715359
3	CSF1R	3.37187695
4	ZAK	3.06883420
5	PINK1	2.99143039
6	GRK7	2.89510581
7	KIT	2.83151725
8	RIPK4	2.74427891
9	TAOK3	2.74158123
10	PIK3CG	2.47054141
11	MAP4K2	2.45185774
12	BMPR2	2.31968853
13	MAP2K3	2.21486026
14	FRK	2.18398537
15	SIK2	2.10570146
16	RPS6KA4	2.06121224
17	TYK2	2.03035045
18	MKNK2	2.01431507
19	BRD4	2.00950593
20	SIK3	1.70020613
21	MAP3K3	1.62530495
22	GRK1	1.48471740
23	CDK19	1.42509949
24	PRKCE	1.40483465
25	EPHB1	1.36565172
26	RIPK1	1.33615275
27	PTK2B	1.15339245
28	IKBKB	1.13960186
29	MKNK1	1.11882936
30	WNK3	1.10376409
31	RPS6KA1	1.05975353
32	TXK	1.01532553
33	MAP3K4	1.00908215
34	JAK1	0.98242245
35	OXSR1	0.96637618
36	MARK3	0.95259474
37	MARK1	0.94255242
38	MAP4K1	0.91328793
39	LYN	0.88865355
40	STK3	0.81747831
41	LCK	0.75330169
42	SGK3	0.75065511
43	CAMK4	0.74750578
44	PAK3	0.74603744
45	WNK4	0.73991554
46	CLK1	0.73337742
47	EIF2AK3	0.72819301
48	MAP2K4	0.72370112
49	PRKCQ	0.72184446
50	CAMKK2	0.70956234
51	SGK2	0.70408158
52	MAPK13	0.68859632
53	TIE1	0.67499250
54	SYK	0.67386136
55	DAPK2	0.66875597
56	STK39	0.66728020
57	MAP2K7	0.64079788
58	SGK494	0.63376875
59	SGK223	0.63376875
60	AKT3	0.62301697
61	CDK7	0.61354854
62	MATK	0.60178028
63	CHEK1	0.60139429
64	TGFBR2	0.59495055
65	RPS6KB2	0.59400436
66	CAMK1	0.58061011
67	MAP3K6	0.57562470
68	VRK1	0.56830265
69	MAPKAPK3	0.56765521
70	STK11	0.56429667
71	PRKAA1	0.52865937
72	SCYL2	0.50582761
73	DYRK2	0.50547775
74	CSNK2A2	0.48853719
75	ERBB3	0.45686604
76	BCKDK	0.44960163
77	EPHA4	0.44440904
78	CDK8	0.44361996
79	IGF1R	0.44120463
80	PRKACB	0.43541183
81	RPS6KA5	0.43039999
82	ABL1	0.41952853
83	CSNK1G2	0.41182723
84	PRKCD	0.40836335
85	PDK1	0.40780375
86	CSNK1G3	0.40092810
87	ADRBK1	0.39791588
88	CHEK2	0.37325344
89	YES1	0.37046386
90	MAP3K5	0.35724163
91	CSNK1A1	0.35403370
92	TBK1	0.34261195
93	FYN	0.32931594
94	PRKCA	0.32614089
95	INSRR	0.31512960
96	PIM1	0.30312506
97	CDC7	0.29766894
98	CDK3	0.29487021
99	JAK3	0.28468601
100	KDR	0.28207530

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	5.33898823
2	Allograft rejection_Homo sapiens_hsa05330	4.24989949
3	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.94028456
4	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.78303958
5	Primary immunodeficiency_Homo sapiens_hsa05340	3.62556475
6	Graft-versus-host disease_Homo sapiens_hsa05332	3.33192868
7	Type I diabetes mellitus_Homo sapiens_hsa04940	2.74883984
8	Antigen processing and presentation_Homo sapiens_hsa04612	2.55937332
9	Viral myocarditis_Homo sapiens_hsa05416	2.30547081
10	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.13735974
11	Staphylococcus aureus infection_Homo sapiens_hsa05150	2.06596131
12	Rheumatoid arthritis_Homo sapiens_hsa05323	1.93326111
13	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.92168045
14	RNA polymerase_Homo sapiens_hsa03020	1.91331551
15	DNA replication_Homo sapiens_hsa03030	1.68571628
16	Phototransduction_Homo sapiens_hsa04744	1.66507462
17	Leishmaniasis_Homo sapiens_hsa05140	1.62228907
18	Ether lipid metabolism_Homo sapiens_hsa00565	1.56760695
19	Nitrogen metabolism_Homo sapiens_hsa00910	1.53964038
20	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.51231480
21	Non-homologous end-joining_Homo sapiens_hsa03450	1.45807227
22	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.38638059
23	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.37832350
24	Sphingolipid metabolism_Homo sapiens_hsa00600	1.35155924
25	Basal transcription factors_Homo sapiens_hsa03022	1.34654962
26	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.27460827
27	Linoleic acid metabolism_Homo sapiens_hsa00591	1.27393031
28	Protein export_Homo sapiens_hsa03060	1.23831859
29	Caffeine metabolism_Homo sapiens_hsa00232	1.18473432
30	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.17970031
31	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.14573631
32	Homologous recombination_Homo sapiens_hsa03440	1.11887034
33	Pyrimidine metabolism_Homo sapiens_hsa00240	1.11011054
34	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.09523209
35	Osteoclast differentiation_Homo sapiens_hsa04380	1.09479577
36	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.01722686
37	Herpes simplex infection_Homo sapiens_hsa05168	0.95573666
38	Salivary secretion_Homo sapiens_hsa04970	0.93936560
39	Base excision repair_Homo sapiens_hsa03410	0.93277598
40	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.90951518
41	Collecting duct acid secretion_Homo sapiens_hsa04966	0.90491288
42	Toxoplasmosis_Homo sapiens_hsa05145	0.88433253
43	Mismatch repair_Homo sapiens_hsa03430	0.85192544
44	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.83490529
45	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.83405060
46	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.82643723
47	Tuberculosis_Homo sapiens_hsa05152	0.81779764
48	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.80521273
49	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.75392974
50	Influenza A_Homo sapiens_hsa05164	0.72194577
51	Alcoholism_Homo sapiens_hsa05034	0.71468524
52	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.70995602
53	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.69308033
54	Fanconi anemia pathway_Homo sapiens_hsa03460	0.69246587
55	Nucleotide excision repair_Homo sapiens_hsa03420	0.67669999
56	Chemokine signaling pathway_Homo sapiens_hsa04062	0.67471365
57	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.65625539
58	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.64919064
59	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.62248223
60	mRNA surveillance pathway_Homo sapiens_hsa03015	0.60362482
61	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.57932077
62	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.55570379
63	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.55409290
64	Phagosome_Homo sapiens_hsa04145	0.55352498
65	Taste transduction_Homo sapiens_hsa04742	0.54667710
66	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.52707966
67	RNA transport_Homo sapiens_hsa03013	0.50878676
68	One carbon pool by folate_Homo sapiens_hsa00670	0.50773697
69	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.50599652
70	Shigellosis_Homo sapiens_hsa05131	0.47847813
71	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.45844083
72	Olfactory transduction_Homo sapiens_hsa04740	0.44825773
73	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.44021136
74	Legionellosis_Homo sapiens_hsa05134	0.42384382
75	Serotonergic synapse_Homo sapiens_hsa04726	0.41489926
76	Retinol metabolism_Homo sapiens_hsa00830	0.39720881
77	beta-Alanine metabolism_Homo sapiens_hsa00410	0.39407299
78	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.38068828
79	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.35606834
80	p53 signaling pathway_Homo sapiens_hsa04115	0.34603236
81	African trypanosomiasis_Homo sapiens_hsa05143	0.34387960
82	RNA degradation_Homo sapiens_hsa03018	0.33936394
83	Tryptophan metabolism_Homo sapiens_hsa00380	0.33196529
84	Glutamatergic synapse_Homo sapiens_hsa04724	0.31674461
85	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.31633902
86	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.31564780
87	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.30278518
88	Circadian entrainment_Homo sapiens_hsa04713	0.29556813
89	Calcium signaling pathway_Homo sapiens_hsa04020	0.29091307
90	Cholinergic synapse_Homo sapiens_hsa04725	0.28815902
91	Purine metabolism_Homo sapiens_hsa00230	0.27872626
92	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.26584369
93	Morphine addiction_Homo sapiens_hsa05032	0.24714268
94	Salmonella infection_Homo sapiens_hsa05132	0.21405771
95	Huntingtons disease_Homo sapiens_hsa05016	0.20888132
96	Platelet activation_Homo sapiens_hsa04611	0.20773736
97	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.20194965
98	Viral carcinogenesis_Homo sapiens_hsa05203	0.19244535
99	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.18173555
100	Pancreatic secretion_Homo sapiens_hsa04972	0.17027565

MRPS31P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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