ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA double-strand break processing (GO:0000729)	4.94748565
2	protein deneddylation (GO:0000338)	4.21366252
3	cullin deneddylation (GO:0010388)	4.16675648
4	DNA integration (GO:0015074)	4.03372526
5	respiratory chain complex IV assembly (GO:0008535)	3.79921876
6	proteasome assembly (GO:0043248)	3.62021372
7	lactate metabolic process (GO:0006089)	3.61222732
8	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.55967912
9	rRNA modification (GO:0000154)	3.44243120
10	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.41067636
11	metallo-sulfur cluster assembly (GO:0031163)	3.39766600
12	iron-sulfur cluster assembly (GO:0016226)	3.39766600
13	establishment of integrated proviral latency (GO:0075713)	3.38159032
14	positive regulation of mitochondrial fission (GO:0090141)	3.23895499
15	ubiquinone biosynthetic process (GO:0006744)	3.19829280
16	double-strand break repair via nonhomologous end joining (GO:0006303)	3.19025620
17	non-recombinational repair (GO:0000726)	3.19025620
18	cytochrome complex assembly (GO:0017004)	3.17444004
19	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.15942759
20	histone H2A acetylation (GO:0043968)	3.15457922
21	preassembly of GPI anchor in ER membrane (GO:0016254)	3.10147249
22	positive regulation of granulocyte differentiation (GO:0030854)	3.10060119
23	ubiquinone metabolic process (GO:0006743)	3.09117212
24	DNA ligation (GO:0006266)	3.08388378
25	pseudouridine synthesis (GO:0001522)	3.07259147
26	regulation of helicase activity (GO:0051095)	3.06975414
27	DNA deamination (GO:0045006)	3.05899462
28	mannosylation (GO:0097502)	3.04777883
29	spliceosomal snRNP assembly (GO:0000387)	3.00487447
30	pyrimidine nucleobase catabolic process (GO:0006208)	2.99441317
31	rRNA methylation (GO:0031167)	2.99014802
32	maturation of 5.8S rRNA (GO:0000460)	2.98618721
33	amino acid salvage (GO:0043102)	2.93481993
34	L-methionine salvage (GO:0071267)	2.93481993
35	L-methionine biosynthetic process (GO:0071265)	2.93481993
36	DNA catabolic process, exonucleolytic (GO:0000738)	2.93051264
37	protein polyglutamylation (GO:0018095)	2.92383959
38	regulation of cilium movement (GO:0003352)	2.92234111
39	DNA replication-dependent nucleosome assembly (GO:0006335)	2.90428536
40	DNA replication-dependent nucleosome organization (GO:0034723)	2.90428536
41	base-excision repair, AP site formation (GO:0006285)	2.90167583
42	platelet dense granule organization (GO:0060155)	2.89127378
43	establishment of viral latency (GO:0019043)	2.88453453
44	V(D)J recombination (GO:0033151)	2.88237833
45	response to pheromone (GO:0019236)	2.82565833
46	ribosome assembly (GO:0042255)	2.81053937
47	positive regulation of protein homodimerization activity (GO:0090073)	2.80075858
48	transcription from RNA polymerase III promoter (GO:0006383)	2.79296154
49	protein complex biogenesis (GO:0070271)	2.77813252
50	7-methylguanosine mRNA capping (GO:0006370)	2.73481019
51	GPI anchor metabolic process (GO:0006505)	2.71621092
52	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.70898672
53	regulation of mitotic spindle checkpoint (GO:1903504)	2.70898672
54	branched-chain amino acid catabolic process (GO:0009083)	2.69046388
55	recombinational repair (GO:0000725)	2.68098095
56	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.66971158
57	transcription from mitochondrial promoter (GO:0006390)	2.66281365
58	peptidyl-histidine modification (GO:0018202)	2.66167948
59	double-strand break repair via homologous recombination (GO:0000724)	2.66076579
60	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.65662297
61	mitochondrial respiratory chain complex assembly (GO:0033108)	2.65527853
62	amino acid activation (GO:0043038)	2.65389463
63	tRNA aminoacylation (GO:0043039)	2.65389463
64	7-methylguanosine RNA capping (GO:0009452)	2.65142486
65	RNA capping (GO:0036260)	2.65142486
66	fucose catabolic process (GO:0019317)	2.64776181
67	L-fucose metabolic process (GO:0042354)	2.64776181
68	L-fucose catabolic process (GO:0042355)	2.64776181
69	tRNA aminoacylation for protein translation (GO:0006418)	2.63708234
70	regulation of oxidative stress-induced neuron death (GO:1903203)	2.63685185
71	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.63124526
72	isotype switching (GO:0045190)	2.63124526
73	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.63124526
74	somatic diversification of immune receptors (GO:0002200)	2.62927087
75	regulation of vacuole organization (GO:0044088)	2.62503299
76	water-soluble vitamin biosynthetic process (GO:0042364)	2.62161959
77	somatic diversification of immune receptors via germline recombination within a single locus (GO:000	2.62103651
78	somatic cell DNA recombination (GO:0016444)	2.62103651
79	C-terminal protein amino acid modification (GO:0018410)	2.60681385
80	C-terminal protein lipidation (GO:0006501)	2.60419896
81	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.58342726
82	termination of RNA polymerase III transcription (GO:0006386)	2.58342726
83	regulation of autophagic vacuole assembly (GO:2000785)	2.56773715
84	anterograde synaptic vesicle transport (GO:0048490)	2.56283509
85	inositol phosphate catabolic process (GO:0071545)	2.55616746
86	GPI anchor biosynthetic process (GO:0006506)	2.55605082
87	neural tube formation (GO:0001841)	2.55242766
88	microtubule depolymerization (GO:0007019)	2.54791502
89	replication fork processing (GO:0031297)	2.54396491
90	intraciliary transport (GO:0042073)	2.54344110
91	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.53929902
92	mitochondrial RNA metabolic process (GO:0000959)	2.52699590
93	ribonucleoprotein complex disassembly (GO:0032988)	2.52317050
94	short-chain fatty acid metabolic process (GO:0046459)	2.52100795
95	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.50781729
96	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.50195472
97	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.50195472
98	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.50195472
99	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.49360056
100	protein localization to cilium (GO:0061512)	2.49096481

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.61073699
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.29377915
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.00372717
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.57837533
5	IGF1R_20145208_ChIP-Seq_DFB_Human	3.55637732
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.39298357
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.04305028
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.98449231
9	VDR_23849224_ChIP-Seq_CD4+_Human	2.96861991
10	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.96544483
11	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.91114039
12	ELK1_19687146_ChIP-ChIP_HELA_Human	2.79910510
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.74234917
14	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.73211296
15	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.58951022
16	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.56307099
17	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.50237646
18	FOXP3_21729870_ChIP-Seq_TREG_Human	2.44992033
19	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.19042312
20	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.06012391
21	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.05539137
22	FUS_26573619_Chip-Seq_HEK293_Human	1.99417487
23	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.99171923
24	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.99159917
25	GBX2_23144817_ChIP-Seq_PC3_Human	1.94957156
26	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.94833105
27	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.86143964
28	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.83446421
29	E2F7_22180533_ChIP-Seq_HELA_Human	1.78063528
30	DCP1A_22483619_ChIP-Seq_HELA_Human	1.76244208
31	EWS_26573619_Chip-Seq_HEK293_Human	1.74971659
32	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.71822114
33	CIITA_25753668_ChIP-Seq_RAJI_Human	1.70241460
34	GABP_19822575_ChIP-Seq_HepG2_Human	1.66092372
35	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.66006285
36	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.63722654
37	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.63245808
38	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.61872440
39	MYC_18940864_ChIP-ChIP_HL60_Human	1.61403585
40	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.53405994
41	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.50012680
42	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.46930024
43	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.40701053
44	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.40624400
45	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.37721994
46	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.37644726
47	ER_23166858_ChIP-Seq_MCF-7_Human	1.35902620
48	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.33808304
49	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.31039396
50	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.30561393
51	IRF1_19129219_ChIP-ChIP_H3396_Human	1.30499879
52	P300_19829295_ChIP-Seq_ESCs_Human	1.30076861
53	KDM5A_27292631_Chip-Seq_BREAST_Human	1.27459939
54	CBP_20019798_ChIP-Seq_JUKART_Human	1.25563654
55	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.25563654
56	VDR_22108803_ChIP-Seq_LS180_Human	1.22522898
57	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.19379658
58	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.18941781
59	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.18892875
60	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.17369320
61	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.15680275
62	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.13900155
63	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.12140291
64	TP53_22573176_ChIP-Seq_HFKS_Human	1.12073704
65	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.11480248
66	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.06561015
67	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.05788172
68	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.05481063
69	TTF2_22483619_ChIP-Seq_HELA_Human	1.03836119
70	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.03608132
71	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.01220352
72	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.00714167
73	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.00195329
74	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.99920740
75	TAF15_26573619_Chip-Seq_HEK293_Human	0.99811147
76	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.98622624
77	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.97100771
78	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.95708116
79	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.93932307
80	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.93094888
81	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.92647894
82	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.91304500
83	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.91230910
84	SMAD4_21799915_ChIP-Seq_A2780_Human	0.87556873
85	XRN2_22483619_ChIP-Seq_HELA_Human	0.87330114
86	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.87181268
87	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.85319641
88	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.85107275
89	GATA3_26560356_Chip-Seq_TH2_Human	0.84592132
90	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.83687458
91	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.82960223
92	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.82605575
93	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.82427566
94	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.81361231
95	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.80080209
96	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.79409757
97	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.77251641
98	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.76683768
99	NCOR_22424771_ChIP-Seq_293T_Human	0.76033402
100	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.73792938

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	4.19523504
2	MP0008058_abnormal_DNA_repair	3.72363593
3	MP0001529_abnormal_vocalization	3.46198663
4	MP0006072_abnormal_retinal_apoptosis	3.20929521
5	MP0010094_abnormal_chromosome_stability	2.89758327
6	MP0005499_abnormal_olfactory_system	2.65385739
7	MP0005394_taste/olfaction_phenotype	2.65385739
8	MP0008789_abnormal_olfactory_epithelium	2.51440035
9	MP0005075_abnormal_melanosome_morpholog	2.49153225
10	MP0009697_abnormal_copulation	2.48909447
11	MP0001984_abnormal_olfaction	2.38980739
12	MP0008877_abnormal_DNA_methylation	2.32375705
13	MP0003693_abnormal_embryo_hatching	2.24667926
14	MP0005253_abnormal_eye_physiology	2.16943666
15	MP0003718_maternal_effect	2.13190225
16	MP0005367_renal/urinary_system_phenotyp	2.07484163
17	MP0000516_abnormal_urinary_system	2.07484163
18	MP0003786_premature_aging	2.07196920
19	MP0006035_abnormal_mitochondrial_morpho	2.02278884
20	MP0002751_abnormal_autonomic_nervous	1.98135045
21	MP0003880_abnormal_central_pattern	1.96204585
22	MP0008007_abnormal_cellular_replicative	1.94418895
23	MP0000372_irregular_coat_pigmentation	1.85664978
24	MP0006036_abnormal_mitochondrial_physio	1.73988586
25	MP0006276_abnormal_autonomic_nervous	1.71969094
26	MP0002822_catalepsy	1.70426279
27	MP0003787_abnormal_imprinting	1.65251274
28	MP0003111_abnormal_nucleus_morphology	1.64374611
29	MP0003806_abnormal_nucleotide_metabolis	1.61855608
30	MP0005645_abnormal_hypothalamus_physiol	1.60701530
31	MP0001968_abnormal_touch/_nociception	1.59717503
32	MP0001986_abnormal_taste_sensitivity	1.58828202
33	MP0008995_early_reproductive_senescence	1.57334866
34	MP0002638_abnormal_pupillary_reflex	1.54218685
35	MP0003077_abnormal_cell_cycle	1.48196651
36	MP0004142_abnormal_muscle_tone	1.43306194
37	MP0003763_abnormal_thymus_physiology	1.36994324
38	MP0009046_muscle_twitch	1.36838638
39	MP0005551_abnormal_eye_electrophysiolog	1.34441808
40	MP0000465_gastrointestinal_hemorrhage	1.32406192
41	MP0002837_dystrophic_cardiac_calcinosis	1.31310374
42	MP0005646_abnormal_pituitary_gland	1.27453715
43	MP0001905_abnormal_dopamine_level	1.20069363
44	MP0003221_abnormal_cardiomyocyte_apopto	1.19648309
45	MP0001764_abnormal_homeostasis	1.15505976
46	MP0005410_abnormal_fertilization	1.13508183
47	MP0003121_genomic_imprinting	1.11434230
48	MP0001929_abnormal_gametogenesis	1.08841031
49	MP0008057_abnormal_DNA_replication	1.06169429
50	MP0005187_abnormal_penis_morphology	1.05649767
51	MP0004134_abnormal_chest_morphology	1.02523159
52	MP0001661_extended_life_span	1.01075867
53	MP0002160_abnormal_reproductive_system	0.98776410
54	MP0000569_abnormal_digit_pigmentation	0.98680103
55	MP0005386_behavior/neurological_phenoty	0.97763472
56	MP0004924_abnormal_behavior	0.97763472
57	MP0000631_abnormal_neuroendocrine_gland	0.93650952
58	MP0002132_abnormal_respiratory_system	0.92224724
59	MP0000358_abnormal_cell_content/	0.91295545
60	MP0008932_abnormal_embryonic_tissue	0.89866351
61	MP0004957_abnormal_blastocyst_morpholog	0.89533675
62	MP0002736_abnormal_nociception_after	0.89208437
63	MP0003698_abnormal_male_reproductive	0.89059573
64	MP0002909_abnormal_adrenal_gland	0.89027199
65	MP0001270_distended_abdomen	0.86384092
66	MP0002234_abnormal_pharynx_morphology	0.85813917
67	MP0005389_reproductive_system_phenotype	0.84768286
68	MP0004381_abnormal_hair_follicle	0.82900652
69	MP0005391_vision/eye_phenotype	0.81844968
70	MP0005220_abnormal_exocrine_pancreas	0.81206990
71	MP0002233_abnormal_nose_morphology	0.79853849
72	MP0008872_abnormal_physiological_respon	0.79773036
73	MP0002184_abnormal_innervation	0.79224911
74	MP0003315_abnormal_perineum_morphology	0.77329706
75	MP0001501_abnormal_sleep_pattern	0.74557858
76	MP0001919_abnormal_reproductive_system	0.70990459
77	MP0005266_abnormal_metabolism	0.70783941
78	MP0002090_abnormal_vision	0.70157420
79	MP0002019_abnormal_tumor_incidence	0.70000449
80	MP0002069_abnormal_eating/drinking_beha	0.67774940
81	MP0004197_abnormal_fetal_growth/weight/	0.67388958
82	MP0000015_abnormal_ear_pigmentation	0.65976703
83	MP0000703_abnormal_thymus_morphology	0.65889288
84	MP0004147_increased_porphyrin_level	0.65526723
85	MP0001145_abnormal_male_reproductive	0.65325038
86	MP0000653_abnormal_sex_gland	0.64973829
87	MP0002272_abnormal_nervous_system	0.63936559
88	MP0005395_other_phenotype	0.63687425
89	MP0002210_abnormal_sex_determination	0.59601061
90	MP0004811_abnormal_neuron_physiology	0.58555859
91	MP0000689_abnormal_spleen_morphology	0.58196718
92	MP0001119_abnormal_female_reproductive	0.58069399
93	MP0002166_altered_tumor_susceptibility	0.57922960
94	MP0002095_abnormal_skin_pigmentation	0.57800871
95	MP0002752_abnormal_somatic_nervous	0.57501432
96	MP0009745_abnormal_behavioral_response	0.55993688
97	MP0003122_maternal_imprinting	0.55675062
98	MP0008775_abnormal_heart_ventricle	0.55537431
99	MP0003656_abnormal_erythrocyte_physiolo	0.55253206
100	MP0001835_abnormal_antigen_presentation	0.55226599

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.21739553
2	Congenital primary aphakia (HP:0007707)	3.20781381
3	Abnormality of the labia minora (HP:0012880)	3.13552899
4	Gait imbalance (HP:0002141)	3.10347955
5	Medial flaring of the eyebrow (HP:0010747)	3.05897236
6	Nephrogenic diabetes insipidus (HP:0009806)	3.03167370
7	Hyperglycinemia (HP:0002154)	2.94039023
8	True hermaphroditism (HP:0010459)	2.93661657
9	Abnormal protein glycosylation (HP:0012346)	2.89958901
10	Abnormal glycosylation (HP:0012345)	2.89958901
11	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.89958901
12	Abnormal protein N-linked glycosylation (HP:0012347)	2.89958901
13	Progressive inability to walk (HP:0002505)	2.87162245
14	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.84205002
15	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.84205002
16	Lipid accumulation in hepatocytes (HP:0006561)	2.78894616
17	Hepatocellular necrosis (HP:0001404)	2.77882821
18	Thyroiditis (HP:0100646)	2.76226629
19	Severe combined immunodeficiency (HP:0004430)	2.76048424
20	Hypothermia (HP:0002045)	2.73202900
21	Tubulointerstitial nephritis (HP:0001970)	2.65566531
22	Pancreatic fibrosis (HP:0100732)	2.64463202
23	Chronic hepatic failure (HP:0100626)	2.62422853
24	Cerebral hypomyelination (HP:0006808)	2.60699029
25	Molar tooth sign on MRI (HP:0002419)	2.51529962
26	Abnormality of midbrain morphology (HP:0002418)	2.51529962
27	Renal cortical cysts (HP:0000803)	2.48284266
28	Inability to walk (HP:0002540)	2.47249839
29	Nephronophthisis (HP:0000090)	2.46509359
30	Hepatic necrosis (HP:0002605)	2.43740050
31	Abnormality of chromosome stability (HP:0003220)	2.38209232
32	Methylmalonic acidemia (HP:0002912)	2.33332838
33	Increased CSF lactate (HP:0002490)	2.32415896
34	Failure to thrive in infancy (HP:0001531)	2.31089845
35	Poor coordination (HP:0002370)	2.30608749
36	Abnormal biliary tract physiology (HP:0012439)	2.28478798
37	Bile duct proliferation (HP:0001408)	2.28478798
38	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.27569636
39	Mitochondrial inheritance (HP:0001427)	2.27490600
40	Increased hepatocellular lipid droplets (HP:0006565)	2.26720586
41	Combined immunodeficiency (HP:0005387)	2.16784536
42	CNS hypomyelination (HP:0003429)	2.16187492
43	Sloping forehead (HP:0000340)	2.15116640
44	Meckel diverticulum (HP:0002245)	2.12955404
45	Increased serum lactate (HP:0002151)	2.12334363
46	Intestinal atresia (HP:0011100)	2.11691142
47	Brushfield spots (HP:0001088)	2.11093224
48	Abnormality of the ileum (HP:0001549)	2.11055411
49	Retinal dysplasia (HP:0007973)	2.08875618
50	Vaginal atresia (HP:0000148)	2.07943979
51	3-Methylglutaconic aciduria (HP:0003535)	2.07215916
52	Type I transferrin isoform profile (HP:0003642)	2.06594793
53	Genital tract atresia (HP:0001827)	2.06177088
54	Abnormality of the metopic suture (HP:0005556)	2.05708616
55	Reduced antithrombin III activity (HP:0001976)	2.04922903
56	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.01605541
57	Absent speech (HP:0001344)	1.98842118
58	Progressive microcephaly (HP:0000253)	1.96955322
59	B lymphocytopenia (HP:0010976)	1.96721067
60	Abnormality of the renal medulla (HP:0100957)	1.95887770
61	Lissencephaly (HP:0001339)	1.95187482
62	IgG deficiency (HP:0004315)	1.93771125
63	Methylmalonic aciduria (HP:0012120)	1.93440330
64	Cerebellar dysplasia (HP:0007033)	1.93381959
65	Acute necrotizing encephalopathy (HP:0006965)	1.91127225
66	Abnormality of the renal cortex (HP:0011035)	1.90037285
67	Acute encephalopathy (HP:0006846)	1.89522137
68	Neoplasm of the adrenal cortex (HP:0100641)	1.87801944
69	Microvesicular hepatic steatosis (HP:0001414)	1.87481403
70	Prominent metopic ridge (HP:0005487)	1.86704749
71	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.86225690
72	Abnormality of eosinophils (HP:0001879)	1.85469909
73	Progressive macrocephaly (HP:0004481)	1.85302197
74	Postaxial foot polydactyly (HP:0001830)	1.85037607
75	Abnormality of endocrine pancreas physiology (HP:0012093)	1.84248187
76	Abnormality of the pancreatic islet cells (HP:0006476)	1.84248187
77	Medulloblastoma (HP:0002885)	1.83575670
78	Lactic acidosis (HP:0003128)	1.83388124
79	Abnormal mitochondria in muscle tissue (HP:0008316)	1.82365491
80	Occipital encephalocele (HP:0002085)	1.82235079
81	Type 2 muscle fiber atrophy (HP:0003554)	1.80521393
82	Volvulus (HP:0002580)	1.80457635
83	Chromsome breakage (HP:0040012)	1.76198522
84	Hypoplasia of the pons (HP:0012110)	1.75923026
85	Postaxial hand polydactyly (HP:0001162)	1.75403189
86	Neoplasm of the adrenal gland (HP:0100631)	1.75049313
87	Increased muscle lipid content (HP:0009058)	1.74854677
88	Abnormality of the pons (HP:0007361)	1.74763700
89	Congenital stationary night blindness (HP:0007642)	1.74392473
90	Muscular hypotonia of the trunk (HP:0008936)	1.73459527
91	Abnormality of the preputium (HP:0100587)	1.73084760
92	Postnatal microcephaly (HP:0005484)	1.71709421
93	Broad foot (HP:0001769)	1.71629769
94	Abnormality of B cell number (HP:0010975)	1.70661167
95	Type II lissencephaly (HP:0007260)	1.70431798
96	Abnormality of glycine metabolism (HP:0010895)	1.70323101
97	Abnormality of serine family amino acid metabolism (HP:0010894)	1.70323101
98	Small intestinal stenosis (HP:0012848)	1.66019807
99	Duodenal stenosis (HP:0100867)	1.66019807
100	Cystic liver disease (HP:0006706)	1.65538921

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.44660174
2	TRIM28	3.42259128
3	ZAK	2.85792934
4	FRK	2.85418253
5	BMPR1B	2.78210833
6	PINK1	2.69625864
7	VRK1	2.47745434
8	CSNK1G3	2.46125453
9	CSNK1A1L	2.40553440
10	MAP2K7	2.35047593
11	VRK2	2.30863623
12	WNK3	2.27657022
13	CSNK1G1	2.16988154
14	SRPK1	2.15308375
15	TAOK3	2.14735965
16	MARK3	2.14233465
17	EIF2AK3	2.13490940
18	BCKDK	2.10044044
19	SIK3	2.03405861
20	CSNK1G2	2.02730294
21	BCR	2.00673923
22	ERBB3	1.97522215
23	NUAK1	1.77586694
24	MAPK13	1.56265570
25	BUB1	1.55144401
26	MAP3K4	1.47887287
27	TLK1	1.45842932
28	PLK3	1.44683635
29	RPS6KA4	1.34969043
30	MST4	1.34374036
31	DYRK2	1.13354472
32	PLK2	1.09305319
33	MARK1	1.05317375
34	STK38L	1.05170473
35	CCNB1	1.03511678
36	TSSK6	1.02503331
37	PLK4	1.01409210
38	ADRBK2	0.97671049
39	EIF2AK1	0.94571513
40	NLK	0.89485588
41	PLK1	0.89312700
42	CDK8	0.88289230
43	TXK	0.87761214
44	SCYL2	0.84131348
45	TNIK	0.81890904
46	ATM	0.81056599
47	MAPKAPK3	0.80973381
48	PBK	0.78523858
49	CASK	0.78169010
50	PRKCE	0.77341498
51	FES	0.72647228
52	ATR	0.70880178
53	BRD4	0.69129826
54	MKNK2	0.68743243
55	CDK3	0.68568109
56	RPS6KA5	0.68269321
57	DYRK3	0.63820743
58	BRSK2	0.62234960
59	FGFR2	0.61213849
60	CLK1	0.60752050
61	NEK1	0.59620048
62	STK16	0.59550957
63	EPHA3	0.58241845
64	OBSCN	0.55644988
65	CAMKK2	0.54581454
66	NEK2	0.54286101
67	TIE1	0.52852197
68	TGFBR1	0.52512571
69	CSNK1D	0.52277940
70	MKNK1	0.52100184
71	GRK1	0.49932781
72	PAK3	0.49701897
73	DAPK1	0.49416511
74	MINK1	0.49134816
75	AURKB	0.47700433
76	MAPKAPK5	0.43621651
77	CDC7	0.42437473
78	EEF2K	0.41319718
79	PRKAA1	0.40875856
80	DYRK1A	0.40068659
81	PRKCQ	0.39018334
82	TRPM7	0.38558158
83	CSNK1A1	0.37869966
84	SIK2	0.37815657
85	FLT3	0.37149258
86	PRKCG	0.37061992
87	RPS6KB1	0.36419168
88	CSNK2A1	0.31562254
89	KDR	0.31257684
90	TTK	0.31094926
91	PAK6	0.30786027
92	PASK	0.30624697
93	CHEK2	0.30393017
94	PDK2	0.30013759
95	CDK9	0.29237033
96	KIT	0.27755017
97	PIM2	0.27551147
98	CSNK2A2	0.26668455
99	TEC	0.25626844
100	EGFR	0.25534426

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Non-homologous end-joining_Homo sapiens_hsa03450	3.35076427
2	RNA polymerase_Homo sapiens_hsa03020	2.99996595
3	Basal transcription factors_Homo sapiens_hsa03022	2.91316018
4	Proteasome_Homo sapiens_hsa03050	2.89812124
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.88006254
6	Fanconi anemia pathway_Homo sapiens_hsa03460	2.77943079
7	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.70869590
8	Homologous recombination_Homo sapiens_hsa03440	2.69107229
9	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.66918994
10	Protein export_Homo sapiens_hsa03060	2.44703058
11	Mismatch repair_Homo sapiens_hsa03430	2.36532772
12	Propanoate metabolism_Homo sapiens_hsa00640	2.33666796
13	Butanoate metabolism_Homo sapiens_hsa00650	2.30411060
14	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.25808878
15	Base excision repair_Homo sapiens_hsa03410	2.11957187
16	RNA degradation_Homo sapiens_hsa03018	2.09104289
17	Spliceosome_Homo sapiens_hsa03040	2.02409170
18	Nucleotide excision repair_Homo sapiens_hsa03420	1.95519624
19	DNA replication_Homo sapiens_hsa03030	1.88409483
20	Phototransduction_Homo sapiens_hsa04744	1.74328674
21	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.71729944
22	RNA transport_Homo sapiens_hsa03013	1.70315528
23	Selenocompound metabolism_Homo sapiens_hsa00450	1.70010063
24	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.69242677
25	Pyrimidine metabolism_Homo sapiens_hsa00240	1.66060510
26	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.63857271
27	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.61423927
28	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.56969493
29	One carbon pool by folate_Homo sapiens_hsa00670	1.55318653
30	Oxidative phosphorylation_Homo sapiens_hsa00190	1.45384724
31	Parkinsons disease_Homo sapiens_hsa05012	1.43714108
32	Fatty acid elongation_Homo sapiens_hsa00062	1.43413771
33	Peroxisome_Homo sapiens_hsa04146	1.33870107
34	Purine metabolism_Homo sapiens_hsa00230	1.33590728
35	Regulation of autophagy_Homo sapiens_hsa04140	1.31611415
36	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.27107890
37	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.22126524
38	Nitrogen metabolism_Homo sapiens_hsa00910	1.20201223
39	Olfactory transduction_Homo sapiens_hsa04740	1.07913365
40	Circadian rhythm_Homo sapiens_hsa04710	1.06268717
41	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.03987599
42	Oocyte meiosis_Homo sapiens_hsa04114	1.03208419
43	Primary immunodeficiency_Homo sapiens_hsa05340	0.99189488
44	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.97385763
45	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.96719702
46	mRNA surveillance pathway_Homo sapiens_hsa03015	0.94446735
47	Steroid biosynthesis_Homo sapiens_hsa00100	0.92383804
48	Huntingtons disease_Homo sapiens_hsa05016	0.90918896
49	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.87100729
50	Cell cycle_Homo sapiens_hsa04110	0.85122237
51	Fatty acid metabolism_Homo sapiens_hsa01212	0.84217333
52	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.79152763
53	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.78653205
54	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.77726148
55	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.77165598
56	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.76257368
57	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.75886617
58	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.75007932
59	Alcoholism_Homo sapiens_hsa05034	0.73020409
60	Metabolic pathways_Homo sapiens_hsa01100	0.68033574
61	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.67874470
62	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.65420529
63	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.64959143
64	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.64469717
65	Nicotine addiction_Homo sapiens_hsa05033	0.64232784
66	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.63645365
67	Alzheimers disease_Homo sapiens_hsa05010	0.61872471
68	Glutathione metabolism_Homo sapiens_hsa00480	0.61186527
69	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.61144978
70	Pyruvate metabolism_Homo sapiens_hsa00620	0.58923874
71	p53 signaling pathway_Homo sapiens_hsa04115	0.56334904
72	Carbon metabolism_Homo sapiens_hsa01200	0.52296478
73	beta-Alanine metabolism_Homo sapiens_hsa00410	0.52225527
74	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.48452151
75	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.47368598
76	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.47050350
77	Linoleic acid metabolism_Homo sapiens_hsa00591	0.46806404
78	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.46057936
79	Taste transduction_Homo sapiens_hsa04742	0.43426250
80	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.43395945
81	GABAergic synapse_Homo sapiens_hsa04727	0.41098672
82	Collecting duct acid secretion_Homo sapiens_hsa04966	0.40719293
83	Folate biosynthesis_Homo sapiens_hsa00790	0.37257045
84	Ether lipid metabolism_Homo sapiens_hsa00565	0.37229751
85	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.37038129
86	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.36571687
87	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.33230619
88	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.31061187
89	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.27158243
90	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.26587873
91	Herpes simplex infection_Homo sapiens_hsa05168	0.25270964
92	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.24354788
93	Lysine degradation_Homo sapiens_hsa00310	0.23823563
94	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.23788180
95	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.23305331
96	Sphingolipid metabolism_Homo sapiens_hsa00600	0.21592328
97	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.20991334
98	Type I diabetes mellitus_Homo sapiens_hsa04940	0.20248619
99	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.17310395
100	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.16109217

MRPS31P4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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