ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	5.26692024
2	pyrimidine nucleobase catabolic process (GO:0006208)	4.81443007
3	protein localization to cilium (GO:0061512)	3.98351119
4	nucleobase catabolic process (GO:0046113)	3.86915478
5	fucose catabolic process (GO:0019317)	3.76955761
6	L-fucose metabolic process (GO:0042354)	3.76955761
7	L-fucose catabolic process (GO:0042355)	3.76955761
8	neural tube formation (GO:0001841)	3.71999231
9	behavioral response to nicotine (GO:0035095)	3.66365742
10	DNA double-strand break processing (GO:0000729)	3.64093439
11	nonmotile primary cilium assembly (GO:0035058)	3.60664237
12	negative regulation of telomere maintenance (GO:0032205)	3.54356702
13	presynaptic membrane assembly (GO:0097105)	3.38409427
14	regulation of telomere maintenance (GO:0032204)	3.35682566
15	intraciliary transport (GO:0042073)	3.30147588
16	seminiferous tubule development (GO:0072520)	3.27496045
17	cilium morphogenesis (GO:0060271)	3.26651908
18	replication fork processing (GO:0031297)	3.25442968
19	protein polyglutamylation (GO:0018095)	3.25040725
20	epithelial cilium movement (GO:0003351)	3.21422817
21	protein complex biogenesis (GO:0070271)	3.20729841
22	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.14211769
23	histone H2A acetylation (GO:0043968)	3.10973137
24	preassembly of GPI anchor in ER membrane (GO:0016254)	3.04329534
25	piRNA metabolic process (GO:0034587)	3.04190768
26	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.99126662
27	NADH dehydrogenase complex assembly (GO:0010257)	2.99126662
28	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.99126662
29	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.99068292
30	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.99068292
31	regulation of translation, ncRNA-mediated (GO:0045974)	2.99068292
32	positive regulation of mitochondrial fission (GO:0090141)	2.97258077
33	mitochondrial respiratory chain complex assembly (GO:0033108)	2.94409190
34	cilium organization (GO:0044782)	2.88606740
35	presynaptic membrane organization (GO:0097090)	2.88414658
36	respiratory chain complex IV assembly (GO:0008535)	2.86913630
37	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.82967887
38	cilium assembly (GO:0042384)	2.81648866
39	detection of light stimulus involved in sensory perception (GO:0050962)	2.80778429
40	detection of light stimulus involved in visual perception (GO:0050908)	2.80778429
41	postsynaptic membrane organization (GO:0001941)	2.80699081
42	olfactory bulb development (GO:0021772)	2.78844740
43	sulfation (GO:0051923)	2.77328650
44	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.77196605
45	head development (GO:0060322)	2.76303696
46	regulation of cilium movement (GO:0003352)	2.75749006
47	axoneme assembly (GO:0035082)	2.75343457
48	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.73868312
49	neuron cell-cell adhesion (GO:0007158)	2.71919395
50	photoreceptor cell maintenance (GO:0045494)	2.71878102
51	regulation of hexokinase activity (GO:1903299)	2.71859997
52	regulation of glucokinase activity (GO:0033131)	2.71859997
53	inositol phosphate catabolic process (GO:0071545)	2.67631374
54	DNA demethylation (GO:0080111)	2.66178277
55	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.63161976
56	cytochrome complex assembly (GO:0017004)	2.61865902
57	pyrimidine dimer repair (GO:0006290)	2.61555495
58	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.61412375
59	gamma-aminobutyric acid transport (GO:0015812)	2.60240356
60	DNA deamination (GO:0045006)	2.57786796
61	retinal ganglion cell axon guidance (GO:0031290)	2.56359317
62	reciprocal DNA recombination (GO:0035825)	2.54562680
63	reciprocal meiotic recombination (GO:0007131)	2.54562680
64	establishment of protein localization to Golgi (GO:0072600)	2.54506299
65	protein localization to synapse (GO:0035418)	2.54193206
66	protein K11-linked deubiquitination (GO:0035871)	2.52523728
67	DNA integration (GO:0015074)	2.51878493
68	recombinational repair (GO:0000725)	2.50942118
69	limb bud formation (GO:0060174)	2.49737597
70	auditory behavior (GO:0031223)	2.49377516
71	anterograde synaptic vesicle transport (GO:0048490)	2.49346548
72	neurotransmitter-gated ion channel clustering (GO:0072578)	2.49266493
73	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.48759830
74	platelet dense granule organization (GO:0060155)	2.48049737
75	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.47907318
76	behavioral response to ethanol (GO:0048149)	2.47468004
77	prenylation (GO:0097354)	2.47243027
78	protein prenylation (GO:0018342)	2.47243027
79	cilium movement (GO:0003341)	2.47109890
80	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.45470694
81	mannosylation (GO:0097502)	2.45388218
82	synapsis (GO:0007129)	2.44231023
83	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	2.44159313
84	double-strand break repair via homologous recombination (GO:0000724)	2.43430179
85	GPI anchor metabolic process (GO:0006505)	2.42837501
86	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.41604522
87	transmission of nerve impulse (GO:0019226)	2.39978445
88	mechanosensory behavior (GO:0007638)	2.39634033
89	resolution of meiotic recombination intermediates (GO:0000712)	2.39283234
90	metallo-sulfur cluster assembly (GO:0031163)	2.38260084
91	iron-sulfur cluster assembly (GO:0016226)	2.38260084
92	sympathetic nervous system development (GO:0048485)	2.37931182
93	rRNA catabolic process (GO:0016075)	2.37747354
94	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.36629870
95	somite development (GO:0061053)	2.36134362
96	protein-cofactor linkage (GO:0018065)	2.35667146
97	DNA methylation involved in gamete generation (GO:0043046)	2.35502332
98	negative regulation of mast cell activation (GO:0033004)	2.33257346
99	inner ear receptor stereocilium organization (GO:0060122)	2.32850498
100	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.32787229

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.85200516
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.51309854
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.16486450
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.14999100
5	VDR_22108803_ChIP-Seq_LS180_Human	3.04989621
6	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.73279685
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.61888903
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.59268202
9	FUS_26573619_Chip-Seq_HEK293_Human	2.45677952
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.38736490
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.38585403
12	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.38158816
13	EWS_26573619_Chip-Seq_HEK293_Human	2.32324559
14	TAF15_26573619_Chip-Seq_HEK293_Human	2.32240144
15	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.30863455
16	IRF1_19129219_ChIP-ChIP_H3396_Human	2.13417796
17	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.12300088
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.08871548
19	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.07846796
20	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.06361109
21	P300_19829295_ChIP-Seq_ESCs_Human	2.01558476
22	EZH2_22144423_ChIP-Seq_EOC_Human	1.99109088
23	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.93094029
24	ER_23166858_ChIP-Seq_MCF-7_Human	1.93066241
25	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.82593463
26	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.79778779
27	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.73463272
28	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.69521788
29	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.69518685
30	CBP_20019798_ChIP-Seq_JUKART_Human	1.69518685
31	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.67950267
32	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.67637315
33	VDR_23849224_ChIP-Seq_CD4+_Human	1.60216873
34	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.56150586
35	ELK1_19687146_ChIP-ChIP_HELA_Human	1.56078511
36	SMAD4_21799915_ChIP-Seq_A2780_Human	1.55602357
37	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.55450368
38	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.55040253
39	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.54650932
40	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.50797134
41	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.50361933
42	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.50283241
43	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.47311823
44	STAT3_23295773_ChIP-Seq_U87_Human	1.45928383
45	MYC_18940864_ChIP-ChIP_HL60_Human	1.44663267
46	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.41647355
47	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.41620424
48	BCAT_22108803_ChIP-Seq_LS180_Human	1.41599792
49	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.40296305
50	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.36772370
51	TP53_22573176_ChIP-Seq_HFKS_Human	1.36015051
52	AR_25329375_ChIP-Seq_VCAP_Human	1.35544983
53	TCF4_23295773_ChIP-Seq_U87_Human	1.35033215
54	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.32895653
55	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.32895653
56	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.32463319
57	RNF2_27304074_Chip-Seq_NSC_Mouse	1.30651687
58	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.30008106
59	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.29745571
60	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.27449841
61	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.24490841
62	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.23955396
63	REST_21632747_ChIP-Seq_MESCs_Mouse	1.23772055
64	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.22683643
65	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.21986509
66	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.21694903
67	RUNX2_22187159_ChIP-Seq_PCA_Human	1.20794973
68	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.20659499
69	SOX2_19829295_ChIP-Seq_ESCs_Human	1.20040541
70	NANOG_19829295_ChIP-Seq_ESCs_Human	1.20040541
71	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.19135437
72	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.18362670
73	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.17552480
74	FOXP3_21729870_ChIP-Seq_TREG_Human	1.15719236
75	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.14416035
76	TCF4_22108803_ChIP-Seq_LS180_Human	1.13237052
77	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.11282505
78	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.09569656
79	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.06578602
80	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.05181615
81	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.05026217
82	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.03692267
83	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.03634981
84	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02794345
85	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.02269630
86	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.01987812
87	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.01525864
88	NCOR_22424771_ChIP-Seq_293T_Human	1.00480742
89	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.99834428
90	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.98522718
91	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.97682449
92	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.97454935
93	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.97182495
94	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.96449733
95	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.96335227
96	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.95598203
97	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.94500191
98	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.94228954
99	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.94228954
100	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.93471459

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	3.31966669
2	MP0003787_abnormal_imprinting	3.02965343
3	MP0008877_abnormal_DNA_methylation	2.92547659
4	MP0003880_abnormal_central_pattern	2.85627016
5	MP0001529_abnormal_vocalization	2.48951364
6	MP0006292_abnormal_olfactory_placode	2.44191717
7	MP0006072_abnormal_retinal_apoptosis	2.28639776
8	MP0003121_genomic_imprinting	2.17981038
9	MP0008058_abnormal_DNA_repair	2.10774583
10	MP0002837_dystrophic_cardiac_calcinosis	2.06489256
11	MP0005551_abnormal_eye_electrophysiolog	2.04300996
12	MP0003122_maternal_imprinting	2.01706629
13	MP0008789_abnormal_olfactory_epithelium	1.93266310
14	MP0005394_taste/olfaction_phenotype	1.93107008
15	MP0005499_abnormal_olfactory_system	1.93107008
16	MP0001984_abnormal_olfaction	1.89612048
17	MP0009046_muscle_twitch	1.88642296
18	MP0006276_abnormal_autonomic_nervous	1.85332570
19	MP0005253_abnormal_eye_physiology	1.82274029
20	MP0000569_abnormal_digit_pigmentation	1.79028853
21	MP0001968_abnormal_touch/_nociception	1.75548889
22	MP0005645_abnormal_hypothalamus_physiol	1.67107452
23	MP0002938_white_spotting	1.62376737
24	MP0001986_abnormal_taste_sensitivity	1.62238774
25	MP0000631_abnormal_neuroendocrine_gland	1.61411512
26	MP0005084_abnormal_gallbladder_morpholo	1.59581873
27	MP0005646_abnormal_pituitary_gland	1.58412084
28	MP0002751_abnormal_autonomic_nervous	1.58016913
29	MP0002272_abnormal_nervous_system	1.52417747
30	MP0001486_abnormal_startle_reflex	1.51380110
31	MP0000778_abnormal_nervous_system	1.49963803
32	MP0009745_abnormal_behavioral_response	1.46328422
33	MP0004142_abnormal_muscle_tone	1.44120619
34	MP0002638_abnormal_pupillary_reflex	1.42282967
35	MP0002736_abnormal_nociception_after	1.36897792
36	MP0003195_calcinosis	1.36092491
37	MP0000372_irregular_coat_pigmentation	1.34889031
38	MP0004133_heterotaxia	1.32483945
39	MP0001485_abnormal_pinna_reflex	1.30682594
40	MP0002822_catalepsy	1.30524390
41	MP0003635_abnormal_synaptic_transmissio	1.30521024
42	MP0002557_abnormal_social/conspecific_i	1.25868716
43	MP0005367_renal/urinary_system_phenotyp	1.25808520
44	MP0000516_abnormal_urinary_system	1.25808520
45	MP0001501_abnormal_sleep_pattern	1.24442928
46	MP0004924_abnormal_behavior	1.23181746
47	MP0005386_behavior/neurological_phenoty	1.23181746
48	MP0008995_early_reproductive_senescence	1.19772472
49	MP0002653_abnormal_ependyma_morphology	1.18645354
50	MP0004885_abnormal_endolymph	1.18046288
51	MP0002064_seizures	1.15840982
52	MP0002572_abnormal_emotion/affect_behav	1.15270672
53	MP0004742_abnormal_vestibular_system	1.14946508
54	MP0003890_abnormal_embryonic-extraembry	1.12890717
55	MP0001188_hyperpigmentation	1.12537809
56	MP0000427_abnormal_hair_cycle	1.11197344
57	MP0002067_abnormal_sensory_capabilities	1.07306599
58	MP0002184_abnormal_innervation	1.06953175
59	MP0002063_abnormal_learning/memory/cond	1.05579863
60	MP0008872_abnormal_physiological_respon	1.05375045
61	MP0002160_abnormal_reproductive_system	1.04113282
62	MP0003698_abnormal_male_reproductive	1.03610630
63	MP0006035_abnormal_mitochondrial_morpho	1.03208692
64	MP0002928_abnormal_bile_duct	1.03008347
65	MP0001929_abnormal_gametogenesis	1.02857638
66	MP0000049_abnormal_middle_ear	1.02051512
67	MP0004147_increased_porphyrin_level	1.01838981
68	MP0005187_abnormal_penis_morphology	1.01813295
69	MP0005174_abnormal_tail_pigmentation	1.01717119
70	MP0003718_maternal_effect	1.01228668
71	MP0002752_abnormal_somatic_nervous	1.00448710
72	MP0005423_abnormal_somatic_nervous	0.99141086
73	MP0001764_abnormal_homeostasis	0.97825742
74	MP0002735_abnormal_chemical_nociception	0.96136262
75	MP0003943_abnormal_hepatobiliary_system	0.95578449
76	MP0002233_abnormal_nose_morphology	0.95376650
77	MP0005075_abnormal_melanosome_morpholog	0.95115602
78	MP0001293_anophthalmia	0.94512727
79	MP0002882_abnormal_neuron_morphology	0.92361432
80	MP0004215_abnormal_myocardial_fiber	0.91821405
81	MP0003567_abnormal_fetal_cardiomyocyte	0.91660413
82	MP0005391_vision/eye_phenotype	0.91229803
83	MP0002876_abnormal_thyroid_physiology	0.91161942
84	MP0002210_abnormal_sex_determination	0.90932523
85	MP0005195_abnormal_posterior_eye	0.88709433
86	MP0000653_abnormal_sex_gland	0.87588380
87	MP0004270_analgesia	0.87311150
88	MP0004859_abnormal_synaptic_plasticity	0.85703651
89	MP0000955_abnormal_spinal_cord	0.85341831
90	MP0003646_muscle_fatigue	0.83486445
91	MP0005389_reproductive_system_phenotype	0.82417314
92	MP0002733_abnormal_thermal_nociception	0.82080084
93	MP0005410_abnormal_fertilization	0.81254727
94	MP0001324_abnormal_eye_pigmentation	0.81212770
95	MP0004811_abnormal_neuron_physiology	0.80613388
96	MP0001145_abnormal_male_reproductive	0.79861120
97	MP0008775_abnormal_heart_ventricle	0.79838679
98	MP0001970_abnormal_pain_threshold	0.79538270
99	MP0004043_abnormal_pH_regulation	0.79460547
100	MP0002095_abnormal_skin_pigmentation	0.78109155

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.81055284
2	True hermaphroditism (HP:0010459)	3.70143707
3	Molar tooth sign on MRI (HP:0002419)	3.63393562
4	Abnormality of midbrain morphology (HP:0002418)	3.63393562
5	Pancreatic fibrosis (HP:0100732)	3.58021167
6	Medial flaring of the eyebrow (HP:0010747)	3.45104435
7	Nephronophthisis (HP:0000090)	3.16250034
8	Gait imbalance (HP:0002141)	3.15486570
9	Congenital primary aphakia (HP:0007707)	3.11185009
10	Chronic hepatic failure (HP:0100626)	3.02334026
11	Abnormality of the labia minora (HP:0012880)	2.99674914
12	Nephrogenic diabetes insipidus (HP:0009806)	2.98339881
13	Type II lissencephaly (HP:0007260)	2.86302099
14	Abnormality of the renal medulla (HP:0100957)	2.65396192
15	Genital tract atresia (HP:0001827)	2.64300805
16	Absent speech (HP:0001344)	2.63556789
17	Vaginal atresia (HP:0000148)	2.60066386
18	Intestinal atresia (HP:0011100)	2.57911718
19	Cerebellar dysplasia (HP:0007033)	2.48705821
20	Retinal dysplasia (HP:0007973)	2.47334464
21	Protruding tongue (HP:0010808)	2.46746920
22	Inability to walk (HP:0002540)	2.44128395
23	Lissencephaly (HP:0001339)	2.43901619
24	Hyperventilation (HP:0002883)	2.43729511
25	Progressive cerebellar ataxia (HP:0002073)	2.43285512
26	Cystic liver disease (HP:0006706)	2.41120022
27	Volvulus (HP:0002580)	2.30143570
28	Abnormality of the renal cortex (HP:0011035)	2.29837455
29	Drooling (HP:0002307)	2.24719286
30	Poor coordination (HP:0002370)	2.24357926
31	Thyroiditis (HP:0100646)	2.23250907
32	Abolished electroretinogram (ERG) (HP:0000550)	2.19665039
33	Renal cortical cysts (HP:0000803)	2.18901332
34	Genetic anticipation (HP:0003743)	2.17513682
35	Progressive inability to walk (HP:0002505)	2.16218286
36	Pendular nystagmus (HP:0012043)	2.16028294
37	Pachygyria (HP:0001302)	2.13430797
38	Anencephaly (HP:0002323)	2.11318207
39	Congenital stationary night blindness (HP:0007642)	2.10734836
40	Gaze-evoked nystagmus (HP:0000640)	2.08516462
41	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.07443622
42	Excessive salivation (HP:0003781)	2.02885933
43	Oligodactyly (hands) (HP:0001180)	2.02809925
44	Male pseudohermaphroditism (HP:0000037)	2.00261493
45	Abnormal biliary tract physiology (HP:0012439)	1.99890451
46	Bile duct proliferation (HP:0001408)	1.99890451
47	Postaxial hand polydactyly (HP:0001162)	1.99211254
48	Widely spaced teeth (HP:0000687)	1.98925687
49	Occipital encephalocele (HP:0002085)	1.95141279
50	Hypothermia (HP:0002045)	1.93243935
51	Attenuation of retinal blood vessels (HP:0007843)	1.92745626
52	Broad-based gait (HP:0002136)	1.91231383
53	Sclerocornea (HP:0000647)	1.90981648
54	3-Methylglutaconic aciduria (HP:0003535)	1.90913321
55	Abnormal rod and cone electroretinograms (HP:0008323)	1.90826651
56	Congenital hepatic fibrosis (HP:0002612)	1.90622300
57	Thyroid-stimulating hormone excess (HP:0002925)	1.89115669
58	Febrile seizures (HP:0002373)	1.88151517
59	Abnormal drinking behavior (HP:0030082)	1.86800212
60	Polydipsia (HP:0001959)	1.86800212
61	Mitochondrial inheritance (HP:0001427)	1.86482642
62	Postaxial foot polydactyly (HP:0001830)	1.84723348
63	Specific learning disability (HP:0001328)	1.84465001
64	Optic nerve hypoplasia (HP:0000609)	1.79048902
65	Narrow forehead (HP:0000341)	1.78618151
66	Astigmatism (HP:0000483)	1.77347431
67	Acute necrotizing encephalopathy (HP:0006965)	1.77272939
68	Polyphagia (HP:0002591)	1.77054798
69	Prominent nasal bridge (HP:0000426)	1.76818170
70	Preaxial hand polydactyly (HP:0001177)	1.76327670
71	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.75868415
72	Tubulointerstitial nephritis (HP:0001970)	1.75590013
73	Severe combined immunodeficiency (HP:0004430)	1.75259908
74	Abnormal hair whorl (HP:0010721)	1.74744616
75	Dialeptic seizures (HP:0011146)	1.74225650
76	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.73393677
77	Absent/shortened dynein arms (HP:0200106)	1.73393677
78	Progressive macrocephaly (HP:0004481)	1.72707117
79	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.72383572
80	Hepatocellular necrosis (HP:0001404)	1.72222153
81	Sloping forehead (HP:0000340)	1.70140032
82	Increased CSF lactate (HP:0002490)	1.69341763
83	Abnormality of DNA repair (HP:0003254)	1.68884600
84	Focal seizures (HP:0007359)	1.68714814
85	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.68324146
86	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.67686634
87	Abnormality of alanine metabolism (HP:0010916)	1.67686634
88	Hyperalaninemia (HP:0003348)	1.67686634
89	Abnormal mitochondria in muscle tissue (HP:0008316)	1.67574001
90	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.67312854
91	Focal motor seizures (HP:0011153)	1.66535161
92	Hyperglycinuria (HP:0003108)	1.66514962
93	Aganglionic megacolon (HP:0002251)	1.66181277
94	Hyperglycinemia (HP:0002154)	1.66080867
95	Dandy-Walker malformation (HP:0001305)	1.65295165
96	Abnormality of the metopic suture (HP:0005556)	1.64694628
97	Scrotal hypoplasia (HP:0000046)	1.63771656
98	Decreased testicular size (HP:0008734)	1.62331539
99	Hepatic necrosis (HP:0002605)	1.61826146
100	Multicystic kidney dysplasia (HP:0000003)	1.61365093

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.63132180
2	WNK3	3.56940174
3	PINK1	3.19622267
4	MAP4K2	3.01115974
5	BMPR1B	2.97149035
6	CASK	2.29295213
7	MAPK13	2.08078898
8	MAP3K4	2.04941600
9	TRIM28	2.03573892
10	TNIK	2.02675827
11	NUAK1	2.00740557
12	BCR	1.93313702
13	ZAK	1.81788899
14	MAP2K7	1.80155826
15	ADRBK2	1.76820849
16	BRSK2	1.67196194
17	ACVR1B	1.66888265
18	TAOK3	1.63114562
19	MKNK2	1.60132459
20	CSNK1G1	1.57621494
21	CSNK1A1L	1.57584041
22	CSNK1G2	1.56004621
23	DYRK2	1.55760649
24	CSNK1G3	1.53257843
25	OXSR1	1.40823915
26	STK39	1.37132702
27	GRK1	1.31497775
28	STK38L	1.29819254
29	WNK4	1.27812851
30	BCKDK	1.26194391
31	MARK1	1.26180872
32	FGFR2	1.24880191
33	PAK3	1.24513388
34	MKNK1	1.20806387
35	BRD4	1.10966472
36	INSRR	1.08390910
37	CDK19	1.08136781
38	EIF2AK3	1.06752330
39	CCNB1	1.06330343
40	NLK	1.04842626
41	PLK4	1.01200332
42	MARK3	0.97691387
43	TLK1	0.97626628
44	EPHA3	0.93479245
45	PIK3CA	0.92713802
46	TGFBR1	0.91165585
47	WEE1	0.89970623
48	VRK1	0.85780906
49	TXK	0.83629526
50	PRKCE	0.83463785
51	ERBB3	0.72604016
52	TIE1	0.68801664
53	DYRK3	0.68559810
54	MINK1	0.68456636
55	PRKCG	0.68025446
56	ATR	0.64841251
57	NTRK2	0.63998410
58	UHMK1	0.63373197
59	TEC	0.63355093
60	PLK2	0.62969799
61	CDK3	0.62881854
62	CAMKK2	0.62397980
63	PLK3	0.62384063
64	NEK2	0.61117542
65	PRKCQ	0.61038480
66	SRPK1	0.60385815
67	NTRK3	0.59609926
68	ATM	0.57904820
69	PKN1	0.56717618
70	SIK2	0.56585496
71	FLT3	0.56061173
72	EPHA4	0.54389477
73	DYRK1A	0.53839531
74	CSNK1D	0.52900622
75	ADRBK1	0.50952429
76	PLK1	0.50577461
77	PASK	0.48564211
78	STK11	0.47505229
79	CDK5	0.47187951
80	MAP2K4	0.46670323
81	OBSCN	0.46137596
82	PNCK	0.44655326
83	CSNK1A1	0.43128373
84	RPS6KA5	0.42970698
85	CAMK2A	0.42549413
86	SGK223	0.41507675
87	SGK494	0.41507675
88	DAPK2	0.39382943
89	STK3	0.38966101
90	SGK2	0.36685318
91	PRKAA1	0.34927689
92	RPS6KB1	0.34780423
93	KIT	0.34183057
94	MAP2K6	0.33664965
95	PRKACA	0.33117665
96	VRK2	0.32901048
97	AKT3	0.32330520
98	MAPKAPK5	0.31742870
99	CSNK1E	0.30068627
100	CAMK1	0.28105812

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.11425379
2	Phototransduction_Homo sapiens_hsa04744	2.87591527
3	Butanoate metabolism_Homo sapiens_hsa00650	2.74070465
4	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.63000299
5	Nicotine addiction_Homo sapiens_hsa05033	2.50218454
6	Fanconi anemia pathway_Homo sapiens_hsa03460	2.39635368
7	Protein export_Homo sapiens_hsa03060	2.38688340
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.32624134
9	Homologous recombination_Homo sapiens_hsa03440	2.26657445
10	Basal transcription factors_Homo sapiens_hsa03022	2.24211106
11	Non-homologous end-joining_Homo sapiens_hsa03450	2.21438757
12	RNA polymerase_Homo sapiens_hsa03020	2.12730890
13	Regulation of autophagy_Homo sapiens_hsa04140	2.08174155
14	Propanoate metabolism_Homo sapiens_hsa00640	2.04102969
15	Nitrogen metabolism_Homo sapiens_hsa00910	1.93776960
16	RNA degradation_Homo sapiens_hsa03018	1.87769961
17	Olfactory transduction_Homo sapiens_hsa04740	1.85510177
18	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.82956380
19	Selenocompound metabolism_Homo sapiens_hsa00450	1.79868365
20	Oxidative phosphorylation_Homo sapiens_hsa00190	1.72006242
21	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.70524297
22	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.66324259
23	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.65210507
24	Collecting duct acid secretion_Homo sapiens_hsa04966	1.59355086
25	Peroxisome_Homo sapiens_hsa04146	1.50107008
26	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.49723988
27	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.49527942
28	Steroid biosynthesis_Homo sapiens_hsa00100	1.43893960
29	Taste transduction_Homo sapiens_hsa04742	1.38800058
30	Parkinsons disease_Homo sapiens_hsa05012	1.37165387
31	GABAergic synapse_Homo sapiens_hsa04727	1.35746904
32	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.32739056
33	Ether lipid metabolism_Homo sapiens_hsa00565	1.28709329
34	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.27965188
35	Linoleic acid metabolism_Homo sapiens_hsa00591	1.26779109
36	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.23169626
37	Morphine addiction_Homo sapiens_hsa05032	1.20341391
38	Circadian entrainment_Homo sapiens_hsa04713	1.17272282
39	Nucleotide excision repair_Homo sapiens_hsa03420	1.14116625
40	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.11977924
41	Circadian rhythm_Homo sapiens_hsa04710	1.08200704
42	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.06252031
43	Glutamatergic synapse_Homo sapiens_hsa04724	1.02474105
44	beta-Alanine metabolism_Homo sapiens_hsa00410	1.02402656
45	Insulin secretion_Homo sapiens_hsa04911	0.98556616
46	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.95390919
47	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.94434975
48	ABC transporters_Homo sapiens_hsa02010	0.91787544
49	Dopaminergic synapse_Homo sapiens_hsa04728	0.89352260
50	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.88318479
51	Huntingtons disease_Homo sapiens_hsa05016	0.88013349
52	Primary immunodeficiency_Homo sapiens_hsa05340	0.87540464
53	RNA transport_Homo sapiens_hsa03013	0.87175081
54	Amphetamine addiction_Homo sapiens_hsa05031	0.87077418
55	Purine metabolism_Homo sapiens_hsa00230	0.84995673
56	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.84775629
57	Mismatch repair_Homo sapiens_hsa03430	0.77984502
58	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.76873218
59	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.75918430
60	Base excision repair_Homo sapiens_hsa03410	0.75815152
61	Spliceosome_Homo sapiens_hsa03040	0.74984934
62	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.74217845
63	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.68909341
64	Pyrimidine metabolism_Homo sapiens_hsa00240	0.67652187
65	Tryptophan metabolism_Homo sapiens_hsa00380	0.62362294
66	Cocaine addiction_Homo sapiens_hsa05030	0.62187195
67	Caffeine metabolism_Homo sapiens_hsa00232	0.62127057
68	Serotonergic synapse_Homo sapiens_hsa04726	0.61769934
69	Alzheimers disease_Homo sapiens_hsa05010	0.61505196
70	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.61440154
71	Chemical carcinogenesis_Homo sapiens_hsa05204	0.61067998
72	Salivary secretion_Homo sapiens_hsa04970	0.59773747
73	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.57265246
74	Renin secretion_Homo sapiens_hsa04924	0.56045823
75	mRNA surveillance pathway_Homo sapiens_hsa03015	0.55978831
76	Metabolic pathways_Homo sapiens_hsa01100	0.53494605
77	Fatty acid metabolism_Homo sapiens_hsa01212	0.53255355
78	Calcium signaling pathway_Homo sapiens_hsa04020	0.52633891
79	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.52524468
80	Cardiac muscle contraction_Homo sapiens_hsa04260	0.52512011
81	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.50954702
82	Oocyte meiosis_Homo sapiens_hsa04114	0.48920114
83	Fatty acid elongation_Homo sapiens_hsa00062	0.45495126
84	One carbon pool by folate_Homo sapiens_hsa00670	0.44570528
85	Retinol metabolism_Homo sapiens_hsa00830	0.43510204
86	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.42967987
87	Long-term depression_Homo sapiens_hsa04730	0.42100435
88	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.39376634
89	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.38746253
90	Axon guidance_Homo sapiens_hsa04360	0.38736822
91	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.37895079
92	Alcoholism_Homo sapiens_hsa05034	0.37531988
93	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.37443297
94	cAMP signaling pathway_Homo sapiens_hsa04024	0.36561500
95	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.35988227
96	Cholinergic synapse_Homo sapiens_hsa04725	0.35400154
97	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.32432355
98	Basal cell carcinoma_Homo sapiens_hsa05217	0.32023824
99	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.28962867
100	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.28204987

MRPS31P5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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