MRPS33

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. The 28S subunit of the mammalian mitoribosome may play a crucial and characteristic role in translation initiation. This gene encodes a 28S subunit protein that is one of the more highly conserved mitochondrial ribosomal proteins among mammals, Drosophila and C. elegans. Splice variants that differ in the 5' UTR have been found for this gene; all variants encode the same protein. Pseudogenes corresponding to this gene are found on chromosomes 1q, 4p, 4q, and 20q NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.75127539
2ATP synthesis coupled proton transport (GO:0015986)7.30035488
3energy coupled proton transport, down electrochemical gradient (GO:0015985)7.30035488
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)7.21027126
5respiratory electron transport chain (GO:0022904)6.25236071
6electron transport chain (GO:0022900)6.12366363
7axon ensheathment in central nervous system (GO:0032291)5.63187355
8central nervous system myelination (GO:0022010)5.63187355
9chaperone-mediated protein transport (GO:0072321)5.60600507
10protein neddylation (GO:0045116)5.50467898
11protein complex biogenesis (GO:0070271)4.95867562
12mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.77744477
13mitochondrial respiratory chain complex I assembly (GO:0032981)4.77744477
14NADH dehydrogenase complex assembly (GO:0010257)4.77744477
15mitochondrial respiratory chain complex assembly (GO:0033108)4.37738762
16ribosomal small subunit assembly (GO:0000028)4.29934298
17establishment of protein localization to mitochondrial membrane (GO:0090151)4.27387843
18behavioral response to nicotine (GO:0035095)4.10358695
19fatty acid elongation (GO:0030497)4.03318519
20hydrogen ion transmembrane transport (GO:1902600)4.00127813
21long-chain fatty acid biosynthetic process (GO:0042759)3.96579151
22translational elongation (GO:0006414)3.92306976
23presynaptic membrane organization (GO:0097090)3.79158132
24presynaptic membrane assembly (GO:0097105)3.76997935
25GTP biosynthetic process (GO:0006183)3.71313529
26neuron cell-cell adhesion (GO:0007158)3.70362167
27proton transport (GO:0015992)3.64895941
28purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.63785735
29substantia nigra development (GO:0021762)3.62812571
30ATP biosynthetic process (GO:0006754)3.61634936
31water-soluble vitamin biosynthetic process (GO:0042364)3.59557601
32hydrogen transport (GO:0006818)3.56338271
33purine nucleoside triphosphate biosynthetic process (GO:0009145)3.56006493
34ribosomal large subunit biogenesis (GO:0042273)3.54199427
35pseudouridine synthesis (GO:0001522)3.53399963
36viral life cycle (GO:0019058)3.51729106
37DNA deamination (GO:0045006)3.50500244
38cellular protein complex disassembly (GO:0043624)3.50093398
39RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.48644846
40tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.48644846
41nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.44921397
42translational initiation (GO:0006413)3.42152671
43proteasome assembly (GO:0043248)3.39606060
44* translation (GO:0006412)3.38925816
45exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.38134961
46dopamine transport (GO:0015872)3.36807500
47regulation of dopamine metabolic process (GO:0042053)3.33798129
48regulation of catecholamine metabolic process (GO:0042069)3.33798129
49inner mitochondrial membrane organization (GO:0007007)3.33055577
50cullin deneddylation (GO:0010388)3.30709414
51ribosomal small subunit biogenesis (GO:0042274)3.30525963
52respiratory chain complex IV assembly (GO:0008535)3.30267228
53cellular ketone body metabolic process (GO:0046950)3.29738919
54maturation of SSU-rRNA (GO:0030490)3.25101492
55nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.24760630
56maturation of 5.8S rRNA (GO:0000460)3.24677526
57regulation of mitochondrial translation (GO:0070129)3.23236975
58negative regulation of neurotransmitter transport (GO:0051589)3.21350418
59protein targeting to mitochondrion (GO:0006626)3.15220011
60ATP hydrolysis coupled proton transport (GO:0015991)3.14753411
61energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.14753411
62mannosylation (GO:0097502)3.13188386
63ribonucleoside triphosphate biosynthetic process (GO:0009201)3.10410537
64L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.08160479
65establishment of protein localization to mitochondrion (GO:0072655)3.05505039
66dopamine biosynthetic process (GO:0042416)3.05482418
67cytochrome complex assembly (GO:0017004)3.05051629
68cellular component biogenesis (GO:0044085)3.03182391
69response to redox state (GO:0051775)3.01659338
70termination of RNA polymerase III transcription (GO:0006386)2.97957962
71transcription elongation from RNA polymerase III promoter (GO:0006385)2.97957962
72protein deneddylation (GO:0000338)2.97505981
73regulation of oxidative phosphorylation (GO:0002082)2.97197151
74rRNA modification (GO:0000154)2.96793923
75platelet dense granule organization (GO:0060155)2.94246108
76neurotransmitter uptake (GO:0001504)2.93672816
77GPI anchor biosynthetic process (GO:0006506)2.93357870
78ketone body metabolic process (GO:1902224)2.93160780
79UTP biosynthetic process (GO:0006228)2.91617133
80protein localization to mitochondrion (GO:0070585)2.87469103
81protein complex disassembly (GO:0043241)2.83812132
82cotranslational protein targeting to membrane (GO:0006613)2.83123135
83protein targeting to membrane (GO:0006612)2.80752670
84macromolecular complex disassembly (GO:0032984)2.77278300
85myelination (GO:0042552)2.74218414
86establishment of integrated proviral latency (GO:0075713)2.72682837
87chromatin remodeling at centromere (GO:0031055)2.71764889
88negative regulation of protein localization to cell surface (GO:2000009)2.71615970
897-methylguanosine RNA capping (GO:0009452)2.70901738
90RNA capping (GO:0036260)2.70901738
917-methylguanosine mRNA capping (GO:0006370)2.70858595
92protein targeting to ER (GO:0045047)2.70814845
93nonmotile primary cilium assembly (GO:0035058)2.70377797
94nucleoside triphosphate biosynthetic process (GO:0009142)2.69721212
95negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.69133053
96intracellular protein transmembrane import (GO:0044743)2.68962569
97CENP-A containing nucleosome assembly (GO:0034080)2.68604560
98establishment of viral latency (GO:0019043)2.68106263
99ubiquinone biosynthetic process (GO:0006744)2.67860470
100tRNA processing (GO:0008033)2.67511165
101axon ensheathment (GO:0008366)2.67179607
102ensheathment of neurons (GO:0007272)2.67179607
103protein localization to cilium (GO:0061512)2.66831799
104protein localization to endoplasmic reticulum (GO:0070972)2.66597352
105guanosine-containing compound biosynthetic process (GO:1901070)2.65991217
106signal peptide processing (GO:0006465)2.65426106
107SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.65176529
108regulation of cellular amino acid metabolic process (GO:0006521)2.64706285
109protein-cofactor linkage (GO:0018065)2.64530259
110cholesterol biosynthetic process (GO:0006695)2.63546450
111positive regulation of protein homodimerization activity (GO:0090073)2.63520292
112preassembly of GPI anchor in ER membrane (GO:0016254)2.61695293
113GPI anchor metabolic process (GO:0006505)2.61344608
114establishment of protein localization to endoplasmic reticulum (GO:0072599)2.61171737
115nuclear-transcribed mRNA catabolic process (GO:0000956)2.60252385
116peptidyl-histidine modification (GO:0018202)2.59136000
117regulation of cilium movement (GO:0003352)2.58929510
118mitochondrion morphogenesis (GO:0070584)2.58863988
119spliceosomal complex assembly (GO:0000245)2.58785456
120mitochondrial transport (GO:0006839)2.57528587
121intracellular protein transmembrane transport (GO:0065002)2.57277654
122neural nucleus development (GO:0048857)2.55747138
123mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.55497140
124positive regulation of mitochondrial fission (GO:0090141)2.55401591
125purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.55381194
126purine nucleoside monophosphate biosynthetic process (GO:0009127)2.55381194
127aerobic respiration (GO:0009060)2.55355119
128negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.55354527
129aldehyde catabolic process (GO:0046185)2.55273047
130regulation of glutamate secretion (GO:0014048)2.53964672
131oxidative phosphorylation (GO:0006119)2.53759264
132rRNA processing (GO:0006364)2.52472197
133viral transcription (GO:0019083)2.50884198
134transferrin transport (GO:0033572)2.50843249
135nucleoside diphosphate phosphorylation (GO:0006165)2.49994926
136mRNA catabolic process (GO:0006402)2.49824143
137organelle disassembly (GO:1903008)2.49726216
138ribonucleoprotein complex biogenesis (GO:0022613)2.49037078
139rRNA metabolic process (GO:0016072)2.48902720
140positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.48045004
141calcium-mediated signaling using intracellular calcium source (GO:0035584)2.47647610
142epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.46998696
143positive regulation of synapse assembly (GO:0051965)2.46009339
144protein K6-linked ubiquitination (GO:0085020)2.45069941
145transmission of nerve impulse (GO:0019226)2.44218121
146neuronal action potential propagation (GO:0019227)2.43782617
147translational termination (GO:0006415)2.43171926
148regulation of feeding behavior (GO:0060259)2.42958755

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.45567869
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.50219846
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.36577091
4EZH2_22144423_ChIP-Seq_EOC_Human3.32727217
5GBX2_23144817_ChIP-Seq_PC3_Human3.13446771
6ZNF274_21170338_ChIP-Seq_K562_Hela3.08333270
7* GABP_17652178_ChIP-ChIP_JURKAT_Human3.06130183
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.82687185
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.76814192
10TAF15_26573619_Chip-Seq_HEK293_Human2.69503974
11* EST1_17652178_ChIP-ChIP_JURKAT_Human2.66850104
12VDR_22108803_ChIP-Seq_LS180_Human2.54394225
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.50214070
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.40720357
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.32102478
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.30003828
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.29287702
18PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.25101982
19* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.08604711
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.07828523
21* FUS_26573619_Chip-Seq_HEK293_Human2.06781147
22BMI1_23680149_ChIP-Seq_NPCS_Mouse2.06077880
23POU3F2_20337985_ChIP-ChIP_501MEL_Human2.01594345
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.98768194
25* ETS1_20019798_ChIP-Seq_JURKAT_Human1.93920960
26* MYC_18555785_ChIP-Seq_MESCs_Mouse1.86533792
27* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.77302165
28JARID2_20064375_ChIP-Seq_MESCs_Mouse1.75956516
29SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.75603750
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.75559427
31* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70934902
32FOXP3_21729870_ChIP-Seq_TREG_Human1.70064815
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69348459
34* EZH2_27304074_Chip-Seq_ESCs_Mouse1.65739505
35SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62446454
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.62181406
37ER_23166858_ChIP-Seq_MCF-7_Human1.60588084
38SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.59496955
39SRF_21415370_ChIP-Seq_HL-1_Mouse1.58254199
40EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.57237178
41* P300_19829295_ChIP-Seq_ESCs_Human1.54758059
42IRF1_19129219_ChIP-ChIP_H3396_Human1.47315041
43EED_16625203_ChIP-ChIP_MESCs_Mouse1.46589197
44TP53_22573176_ChIP-Seq_HFKS_Human1.45233906
45SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.44283756
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.43626956
47OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42662622
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42358765
49IGF1R_20145208_ChIP-Seq_DFB_Human1.41510066
50SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.38666937
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.38560296
52ELK1_19687146_ChIP-ChIP_HELA_Human1.37975329
53EWS_26573619_Chip-Seq_HEK293_Human1.37647814
54* TTF2_22483619_ChIP-Seq_HELA_Human1.35330865
55* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.34688883
56FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.34094933
57PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33901473
58SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.32530863
59BP1_19119308_ChIP-ChIP_Hs578T_Human1.31972099
60JARID2_20075857_ChIP-Seq_MESCs_Mouse1.31706885
61RNF2_27304074_Chip-Seq_NSC_Mouse1.31532422
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.30906861
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.30906861
64E2F4_17652178_ChIP-ChIP_JURKAT_Human1.29839375
65PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29481483
66RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28142712
67NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.27649714
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27355178
69MYC_18358816_ChIP-ChIP_MESCs_Mouse1.26179195
70* REST_21632747_ChIP-Seq_MESCs_Mouse1.24751891
71* VDR_23849224_ChIP-Seq_CD4+_Human1.23070712
72GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.22039432
73RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.21667586
74EZH2_18974828_ChIP-Seq_MESCs_Mouse1.16234052
75RNF2_18974828_ChIP-Seq_MESCs_Mouse1.16234052
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.15539773
77EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15311088
78ELF1_17652178_ChIP-ChIP_JURKAT_Human1.15207375
79AR_20517297_ChIP-Seq_VCAP_Human1.14593620
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.13014840
81NANOG_18555785_Chip-Seq_ESCs_Mouse1.12342412
82YY1_21170310_ChIP-Seq_MESCs_Mouse1.12017304
83* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11630114
84POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11593683
85POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11055895
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09671346
87* GABP_19822575_ChIP-Seq_HepG2_Human1.09473336
88CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.08772824
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08542004
90TAL1_26923725_Chip-Seq_HPCs_Mouse1.07894902
91MTF2_20144788_ChIP-Seq_MESCs_Mouse1.07830017
92HTT_18923047_ChIP-ChIP_STHdh_Human1.07151747
93IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07054930
94CBP_20019798_ChIP-Seq_JUKART_Human1.07054930
95* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.05889240
96STAT3_18555785_Chip-Seq_ESCs_Mouse1.05293822
97ELK1_22589737_ChIP-Seq_MCF10A_Human1.05168010
98* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.04788814
99NCOR_22424771_ChIP-Seq_293T_Human1.04577591
100* JUN_21703547_ChIP-Seq_K562_Human1.04550381
101SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04016389
102SALL1_21062744_ChIP-ChIP_HESCs_Human1.03609699
103* XRN2_22483619_ChIP-Seq_HELA_Human1.03236063
104ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.03200863
105DCP1A_22483619_ChIP-Seq_HELA_Human1.03154399
106CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03002920
107P53_22387025_ChIP-Seq_ESCs_Mouse1.02820831
108PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02647706
109EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.02634700
110CMYC_18555785_Chip-Seq_ESCs_Mouse1.02323458
111* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.02139619
112P300_18555785_Chip-Seq_ESCs_Mouse1.01919367
113EZH2_27294783_Chip-Seq_ESCs_Mouse1.01853352
114CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.00502600
115* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00413907
116SUZ12_27294783_Chip-Seq_ESCs_Mouse0.99753750
117GATA3_21878914_ChIP-Seq_MCF-7_Human0.99689882
118TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98325409
119ERG_20517297_ChIP-Seq_VCAP_Human0.98317152
120SOX2_18555785_Chip-Seq_ESCs_Mouse0.97751231
121FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97716194
122RUNX1_27457419_Chip-Seq_LIVER_Mouse0.97201117
123* REST_18959480_ChIP-ChIP_MESCs_Mouse0.96962467
124BCAT_22108803_ChIP-Seq_LS180_Human0.96819893
125NFE2_27457419_Chip-Seq_LIVER_Mouse0.96274112
126REST_19997604_ChIP-ChIP_NEURONS_Mouse0.95196131
127E2F1_18555785_Chip-Seq_ESCs_Mouse0.95092354
128SMAD4_21799915_ChIP-Seq_A2780_Human0.95070448
129SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94868668
130ETV2_25802403_ChIP-Seq_MESCs_Mouse0.94354984
131SOX2_19829295_ChIP-Seq_ESCs_Human0.93869297
132NANOG_19829295_ChIP-Seq_ESCs_Human0.93869297
133CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.92958830
134PIAS1_25552417_ChIP-Seq_VCAP_Human0.92907322
135MYC_18940864_ChIP-ChIP_HL60_Human0.92255394
136* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.91889607
137TCF4_22108803_ChIP-Seq_LS180_Human0.90922039
138* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.90794428
139YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90333358
140AR_25329375_ChIP-Seq_VCAP_Human0.89865886
141KLF5_20875108_ChIP-Seq_MESCs_Mouse0.89247141

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.15663401
2MP0001529_abnormal_vocalization4.03524889
3MP0001905_abnormal_dopamine_level3.31394429
4MP0009379_abnormal_foot_pigmentation2.91949455
5MP0006276_abnormal_autonomic_nervous2.69500629
6MP0002272_abnormal_nervous_system2.36419832
7MP0004270_analgesia2.32315807
8MP0002736_abnormal_nociception_after2.30772288
9MP0008877_abnormal_DNA_methylation2.28160837
10MP0009745_abnormal_behavioral_response2.24538342
11MP0002064_seizures2.21886127
12MP0003136_yellow_coat_color2.21146396
13MP0001968_abnormal_touch/_nociception2.21108423
14MP0001188_hyperpigmentation2.19468227
15MP0005171_absent_coat_pigmentation2.13380237
16MP0003195_calcinosis2.12392174
17MP0000920_abnormal_myelination2.09094601
18MP0005409_darkened_coat_color2.05731467
19MP0003635_abnormal_synaptic_transmissio2.02263381
20MP0002734_abnormal_mechanical_nocicepti1.99112875
21MP0003646_muscle_fatigue1.96056038
22MP0004142_abnormal_muscle_tone1.94936222
23MP0002572_abnormal_emotion/affect_behav1.94833220
24MP0002638_abnormal_pupillary_reflex1.92257120
25MP0001486_abnormal_startle_reflex1.90747578
26MP0005423_abnormal_somatic_nervous1.90213493
27MP0001440_abnormal_grooming_behavior1.90212979
28MP0009046_muscle_twitch1.86903474
29MP0003806_abnormal_nucleotide_metabolis1.84228432
30MP0005379_endocrine/exocrine_gland_phen1.81018487
31MP0002837_dystrophic_cardiac_calcinosis1.78221295
32MP0002735_abnormal_chemical_nociception1.74370744
33MP0003011_delayed_dark_adaptation1.74193247
34MP0002163_abnormal_gland_morphology1.72486357
35MP0002063_abnormal_learning/memory/cond1.69171011
36MP0008875_abnormal_xenobiotic_pharmacok1.68034418
37MP0008058_abnormal_DNA_repair1.67753364
38MP0005646_abnormal_pituitary_gland1.65370898
39MP0001984_abnormal_olfaction1.64297713
40MP0001970_abnormal_pain_threshold1.62659970
41MP0000778_abnormal_nervous_system1.62027804
42MP0002822_catalepsy1.59470713
43MP0001485_abnormal_pinna_reflex1.56910992
44MP0001986_abnormal_taste_sensitivity1.56381605
45MP0004924_abnormal_behavior1.56354088
46MP0005386_behavior/neurological_phenoty1.56354088
47MP0010386_abnormal_urinary_bladder1.54038511
48MP0004742_abnormal_vestibular_system1.53980176
49MP0004859_abnormal_synaptic_plasticity1.53903116
50MP0001501_abnormal_sleep_pattern1.53733971
51MP0002067_abnormal_sensory_capabilities1.52092140
52MP0006292_abnormal_olfactory_placode1.46869588
53MP0002733_abnormal_thermal_nociception1.43907076
54MP0005084_abnormal_gallbladder_morpholo1.42585922
55MP0000569_abnormal_digit_pigmentation1.42360365
56MP0000372_irregular_coat_pigmentation1.42084245
57MP0006072_abnormal_retinal_apoptosis1.42055136
58MP0004133_heterotaxia1.37454348
59MP0002653_abnormal_ependyma_morphology1.36926912
60MP0005645_abnormal_hypothalamus_physiol1.35817428
61MP0002876_abnormal_thyroid_physiology1.35707701
62MP0003283_abnormal_digestive_organ1.35222018
63MP0005551_abnormal_eye_electrophysiolog1.34301816
64MP0003122_maternal_imprinting1.33030161
65MP0004885_abnormal_endolymph1.30701991
66MP0002160_abnormal_reproductive_system1.29798303
67MP0005174_abnormal_tail_pigmentation1.28656731
68MP0006036_abnormal_mitochondrial_physio1.26763882
69MP0001963_abnormal_hearing_physiology1.18826967
70MP0002229_neurodegeneration1.18640041
71MP0002095_abnormal_skin_pigmentation1.18243882
72MP0008995_early_reproductive_senescence1.18092347
73MP0005332_abnormal_amino_acid1.17995029
74MP0002184_abnormal_innervation1.17078808
75MP0005389_reproductive_system_phenotype1.15060327
76MP0003950_abnormal_plasma_membrane1.12323204
77MP0003693_abnormal_embryo_hatching1.11565869
78MP0004215_abnormal_myocardial_fiber1.11360803
79MP0000631_abnormal_neuroendocrine_gland1.09990172
80MP0002557_abnormal_social/conspecific_i1.09525140
81MP0000026_abnormal_inner_ear1.09004375
82MP0002882_abnormal_neuron_morphology1.08081191
83MP0002938_white_spotting1.06096250
84MP0002066_abnormal_motor_capabilities/c1.05840906
85MP0003329_amyloid_beta_deposits1.05836663
86MP0004043_abnormal_pH_regulation1.04977965
87MP0005408_hypopigmentation1.03319542
88MP0006035_abnormal_mitochondrial_morpho1.02698798
89MP0002752_abnormal_somatic_nervous1.02549237
90MP0003634_abnormal_glial_cell1.01780013
91MP0003718_maternal_effect1.01678939
92MP0002102_abnormal_ear_morphology1.01128533
93MP0008789_abnormal_olfactory_epithelium0.98322814
94MP0000427_abnormal_hair_cycle0.98212157
95MP0001919_abnormal_reproductive_system0.98069479
96MP0005253_abnormal_eye_physiology0.96510813
97MP0002234_abnormal_pharynx_morphology0.95024804
98MP0000955_abnormal_spinal_cord0.94633916
99MP0008260_abnormal_autophagy0.93928007
100MP0003890_abnormal_embryonic-extraembry0.93084082
101MP0004145_abnormal_muscle_electrophysio0.91951321
102MP0002210_abnormal_sex_determination0.91389849
103MP0005636_abnormal_mineral_homeostasis0.91007841
104MP0001764_abnormal_homeostasis0.90870091
105MP0003137_abnormal_impulse_conducting0.90003300
106MP0005394_taste/olfaction_phenotype0.89967147
107MP0005499_abnormal_olfactory_system0.89967147
108MP0001502_abnormal_circadian_rhythm0.89363271
109MP0005085_abnormal_gallbladder_physiolo0.88647533
110MP0003252_abnormal_bile_duct0.86977367
111MP0002751_abnormal_autonomic_nervous0.86683733
112MP0005075_abnormal_melanosome_morpholog0.85704730
113MP0001346_abnormal_lacrimal_gland0.85351821
114MP0005410_abnormal_fertilization0.85277308
115MP0001664_abnormal_digestion0.85028884
116MP0003786_premature_aging0.82796419
117MP0001727_abnormal_embryo_implantation0.82210386
118MP0008569_lethality_at_weaning0.81406759
119MP0001293_anophthalmia0.81290356
120MP0004147_increased_porphyrin_level0.81160787
121MP0001929_abnormal_gametogenesis0.80213558
122MP0004381_abnormal_hair_follicle0.79824432
123MP0003938_abnormal_ear_development0.79609002
124MP0004019_abnormal_vitamin_homeostasis0.78974469
125MP0003690_abnormal_glial_cell0.78437071
126MP0008872_abnormal_physiological_respon0.77542595
127MP0000015_abnormal_ear_pigmentation0.77113331
128MP0003698_abnormal_male_reproductive0.76730799
129MP0009697_abnormal_copulation0.76671297
130MP0010094_abnormal_chromosome_stability0.75974575
131MP0003632_abnormal_nervous_system0.73835002
132MP0003631_nervous_system_phenotype0.71311827
133MP0004036_abnormal_muscle_relaxation0.68577970
134MP0002277_abnormal_respiratory_mucosa0.68046788
135MP0005195_abnormal_posterior_eye0.67708362
136MP0000462_abnormal_digestive_system0.66226779
137MP0003787_abnormal_imprinting0.65783427
138MP0003186_abnormal_redox_activity0.64744569
139MP0002152_abnormal_brain_morphology0.64649643

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.59899139
2Abnormal mitochondria in muscle tissue (HP:0008316)5.87631064
3Mitochondrial inheritance (HP:0001427)5.79036252
4Progressive macrocephaly (HP:0004481)5.55150907
5Acute encephalopathy (HP:0006846)5.29757454
6Increased hepatocellular lipid droplets (HP:0006565)4.95340277
7Increased CSF lactate (HP:0002490)4.87057606
8Hepatocellular necrosis (HP:0001404)4.70672876
9Renal Fanconi syndrome (HP:0001994)4.63178475
10Lipid accumulation in hepatocytes (HP:0006561)4.31746339
11Abnormality of glycolysis (HP:0004366)4.16642604
12Increased serum pyruvate (HP:0003542)4.16642604
133-Methylglutaconic aciduria (HP:0003535)4.04814273
14Hepatic necrosis (HP:0002605)3.90867143
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.83317576
16Leukodystrophy (HP:0002415)3.66695812
17Pancreatic cysts (HP:0001737)3.63656439
18Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.62804742
19Optic disc pallor (HP:0000543)3.56129631
20Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.52605963
21Molar tooth sign on MRI (HP:0002419)3.47099877
22Abnormality of midbrain morphology (HP:0002418)3.47099877
23Increased intramyocellular lipid droplets (HP:0012240)3.46463595
24Cerebral edema (HP:0002181)3.35813253
25Parakeratosis (HP:0001036)3.33079575
26Exercise intolerance (HP:0003546)3.27944719
27Respiratory failure (HP:0002878)3.24340440
28Congenital, generalized hypertrichosis (HP:0004540)3.15557031
29Exertional dyspnea (HP:0002875)3.10438965
30Abnormality of renal resorption (HP:0011038)3.05938958
31Hypothermia (HP:0002045)3.04119288
32Lactic acidosis (HP:0003128)3.02317965
33Nephronophthisis (HP:0000090)2.99042429
34Increased serum lactate (HP:0002151)2.93951961
35Congenital stationary night blindness (HP:0007642)2.93485718
36Decreased activity of mitochondrial respiratory chain (HP:0008972)2.92859074
37Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.92859074
38Degeneration of the lateral corticospinal tracts (HP:0002314)2.90652085
39Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.90652085
40Focal motor seizures (HP:0011153)2.90305722
41Medial flaring of the eyebrow (HP:0010747)2.88610834
42Abnormality of alanine metabolism (HP:0010916)2.83815593
43Hyperalaninemia (HP:0003348)2.83815593
44Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.83815593
45Increased muscle lipid content (HP:0009058)2.77876694
46Neuroendocrine neoplasm (HP:0100634)2.75376232
47Respiratory difficulties (HP:0002880)2.67271765
48Pheochromocytoma (HP:0002666)2.62794261
49Sensory axonal neuropathy (HP:0003390)2.57779495
50Gait imbalance (HP:0002141)2.54804834
51Birth length less than 3rd percentile (HP:0003561)2.51966321
52Congenital primary aphakia (HP:0007707)2.50584874
53X-linked dominant inheritance (HP:0001423)2.45528492
54Reticulocytopenia (HP:0001896)2.45261202
55Myokymia (HP:0002411)2.44989697
56Abnormality of the renal medulla (HP:0100957)2.40700087
57Nephrogenic diabetes insipidus (HP:0009806)2.39943026
58Abnormality of the renal cortex (HP:0011035)2.39416976
59Sclerocornea (HP:0000647)2.36608144
60Retinal dysplasia (HP:0007973)2.36603213
61Neurofibrillary tangles (HP:0002185)2.36534186
62Cerebral hypomyelination (HP:0006808)2.28630981
63Abnormal ciliary motility (HP:0012262)2.26142563
64Vaginal atresia (HP:0000148)2.24935481
65Congenital ichthyosiform erythroderma (HP:0007431)2.23941751
66Genital tract atresia (HP:0001827)2.23815607
67Hyperventilation (HP:0002883)2.23247180
68Lethargy (HP:0001254)2.21991355
69Large for gestational age (HP:0001520)2.17392562
70Hyperphosphaturia (HP:0003109)2.12391450
71Male pseudohermaphroditism (HP:0000037)2.11132815
72Pendular nystagmus (HP:0012043)2.10886433
73Renal cortical cysts (HP:0000803)2.09008326
74Atonic seizures (HP:0010819)2.08304651
75Furrowed tongue (HP:0000221)2.07370425
76Abnormal hair whorl (HP:0010721)2.06072275
77Type II lissencephaly (HP:0007260)2.05348406
78Emotional lability (HP:0000712)2.03178311
79Glycosuria (HP:0003076)2.01031489
80Abnormality of urine glucose concentration (HP:0011016)2.01031489
81CNS demyelination (HP:0007305)2.00144694
82Methylmalonic acidemia (HP:0002912)1.98818928
83Epileptic encephalopathy (HP:0200134)1.98539795
84Delusions (HP:0000746)1.95949476
85Abnormal respiratory epithelium morphology (HP:0012253)1.95714368
86Abnormal respiratory motile cilium morphology (HP:0005938)1.95714368
87Renal tubular dysfunction (HP:0000124)1.95553057
88Hyperglycinuria (HP:0003108)1.95410784
89Concave nail (HP:0001598)1.94083002
90Microvesicular hepatic steatosis (HP:0001414)1.93328264
91Abnormal biliary tract physiology (HP:0012439)1.93215982
92Bile duct proliferation (HP:0001408)1.93215982
93Abnormal protein glycosylation (HP:0012346)1.92456077
94Abnormal glycosylation (HP:0012345)1.92456077
95Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.92456077
96Abnormal protein N-linked glycosylation (HP:0012347)1.92456077
97Abnormality of the pons (HP:0007361)1.92320789
98Limb dystonia (HP:0002451)1.92189745
99Abnormality of cells of the erythroid lineage (HP:0012130)1.92093759
100Cystic liver disease (HP:0006706)1.92048492
101Abnormal respiratory motile cilium physiology (HP:0012261)1.90396371
102Attenuation of retinal blood vessels (HP:0007843)1.88568029
103Abnormality of serum amino acid levels (HP:0003112)1.88366486
104Abnormal pupillary function (HP:0007686)1.86597997
105Pallor (HP:0000980)1.85218133
106Hypoplasia of the pons (HP:0012110)1.85206541
107Aplasia/Hypoplasia of the tongue (HP:0010295)1.84066111
108Abnormality of the corticospinal tract (HP:0002492)1.83182678
109Hyperglycinemia (HP:0002154)1.83131657
110Generalized aminoaciduria (HP:0002909)1.82929863
111Absent thumb (HP:0009777)1.80822245
112Abolished electroretinogram (ERG) (HP:0000550)1.80359349
113Autoamputation (HP:0001218)1.79184762
114Abnormal urine phosphate concentration (HP:0012599)1.79108791
115Cerebral hemorrhage (HP:0001342)1.78713834
116Anencephaly (HP:0002323)1.78516814
117Peripheral hypomyelination (HP:0007182)1.78147797
118Dynein arm defect of respiratory motile cilia (HP:0012255)1.78043279
119Absent/shortened dynein arms (HP:0200106)1.78043279
120Aplasia/hypoplasia of the uterus (HP:0008684)1.77894024
121Patchy hypopigmentation of hair (HP:0011365)1.74753584
122Amniotic constriction ring (HP:0009775)1.74316355
123Abnormality of placental membranes (HP:0011409)1.74316355
124Abnormal rod and cone electroretinograms (HP:0008323)1.70123522
125Pancreatic fibrosis (HP:0100732)1.69742529
126Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.69155541
127Cerebral inclusion bodies (HP:0100314)1.68985890
128Abnormal number of erythroid precursors (HP:0012131)1.68948380
129Macrocytic anemia (HP:0001972)1.68460922
130Abnormal drinking behavior (HP:0030082)1.66962928
131Polydipsia (HP:0001959)1.66962928
132Dialeptic seizures (HP:0011146)1.66762128
133Tubular atrophy (HP:0000092)1.66018130
134Poor coordination (HP:0002370)1.65017857
135Abnormal autonomic nervous system physiology (HP:0012332)1.64997452
136True hermaphroditism (HP:0010459)1.64835769
137Anxiety (HP:0000739)1.63369361
138Broad-based gait (HP:0002136)1.63214633
139Esotropia (HP:0000565)1.61819262
140Methylmalonic aciduria (HP:0012120)1.61327537
141CNS hypomyelination (HP:0003429)1.60002484
142Aplasia/Hypoplasia of the sacrum (HP:0008517)1.57514476
143Type I transferrin isoform profile (HP:0003642)1.55344864
144Aplasia/Hypoplasia of the lens (HP:0008063)1.55336172
145Absence seizures (HP:0002121)1.52572543

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK3.56062577
2STK393.40479260
3CASK3.39310709
4VRK23.06059395
5FRK3.04377876
6OXSR12.72272420
7CDK192.63182670
8NME12.62664372
9PBK2.53707337
10MAP3K122.53225489
11STK162.43832470
12ACVR1B2.38332112
13MST42.29958720
14BCR2.26342469
15PNCK2.19793749
16TNIK2.08717573
17ARAF2.06535157
18GRK12.06518646
19MAP4K22.00712700
20GRK71.88187604
21MUSK1.84522625
22BMPR21.84234805
23WNK41.81058990
24INSRR1.79362608
25MAPKAPK51.76059949
26NUAK11.73771135
27BUB11.71094123
28MAP2K71.70257371
29BMPR1B1.64597885
30EPHA41.60659889
31BCKDK1.57343311
32ADRBK21.56763977
33VRK11.55354416
34GRK51.52258216
35PLK21.37455176
36LIMK11.35954132
37CSNK1G31.32745215
38PHKG11.32721597
39PHKG21.32721597
40CAMK2B1.28774618
41CDC71.25995752
42TLK11.24913626
43UHMK11.24666502
44NTRK31.19952200
45MYLK1.19923960
46MAPK131.19804542
47RIPK41.19556000
48NME21.17072398
49EIF2AK31.14231446
50TGFBR11.07535019
51DYRK21.06801063
52BRAF1.04037872
53PKN11.03947150
54NEK11.03784939
55CAMK2A1.00714932
56NEK60.99542439
57CAMK2D0.99192448
58FGR0.97366720
59PASK0.95099624
60MAP3K40.93282709
61TRIM280.89268089
62DAPK20.88786463
63BRSK20.88107815
64CSNK1G10.87949772
65TAF10.87700529
66CSNK1G20.87576212
67ADRBK10.86648962
68MARK10.85194726
69ROCK20.81643674
70CSNK1A1L0.81102375
71CAMKK20.80126090
72STK38L0.78383732
73TSSK60.76575793
74OBSCN0.75331139
75PLK10.75156370
76CAMK2G0.74378010
77PRKCE0.73726520
78NTRK10.70724422
79MAPK150.67938856
80SRPK10.67887559
81PRPF4B0.67411443
82MINK10.65251110
83TXK0.63821126
84MAPKAPK30.63578167
85TAOK30.63570338
86CDK80.63361014
87FES0.63185376
88EIF2AK10.62693702
89CHEK20.61888431
90WNK30.61159812
91CCNB10.61063181
92CDK140.60842832
93PIK3CA0.60090825
94IRAK20.58772984
95TESK20.57652388
96PAK30.56649526
97CDK50.55725953
98MAP2K60.55721568
99TTK0.55634744
100PRKCQ0.55218088
101MKNK10.55030582
102PDK20.54676875
103SGK4940.54469670
104SGK2230.54469670
105PRKCG0.54427831
106CDK180.54324346
107ABL20.53995147
108PRKACA0.53258482
109AURKB0.52790462
110AKT30.52729769
111ERBB30.52039813
112CSNK2A20.51538552
113PLK40.51468021
114CDK11A0.50227339
115SIK30.50118254
116YES10.50094296
117CDK150.49923290
118CSNK2A10.49701907
119WNK10.49198041
120PIM20.49054611
121DYRK1A0.49051635
122RPS6KA50.48633835
123PTK2B0.48137586
124PLK30.47166079
125MKNK20.47044944
126PRKCI0.45673194
127NEK20.44440293
128IRAK40.44201966
129TIE10.43622940
130IRAK10.41743156
131AURKA0.41234793
132ATR0.41205504
133TEC0.40971408
134CDK30.40899387
135PINK10.39131176
136PRKG10.39019630
137MAP2K40.38344640
138CSNK1E0.36967210
139NTRK20.36740775
140CSNK1A10.36650756
141IKBKB0.36417341
142ILK0.35542822
143DYRK30.35090951
144WEE10.34182299

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.95574431
2Parkinsons disease_Homo sapiens_hsa050124.89127713
3Alzheimers disease_Homo sapiens_hsa050103.87171153
4Protein export_Homo sapiens_hsa030603.53461919
5Huntingtons disease_Homo sapiens_hsa050163.45757728
6Proteasome_Homo sapiens_hsa030503.17393524
7Ribosome_Homo sapiens_hsa030103.15481085
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.91716495
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.61325205
10Collecting duct acid secretion_Homo sapiens_hsa049662.45458964
11Cardiac muscle contraction_Homo sapiens_hsa042602.27286602
12RNA polymerase_Homo sapiens_hsa030202.24845057
13Fatty acid elongation_Homo sapiens_hsa000622.06965349
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.81261331
15Nicotine addiction_Homo sapiens_hsa050331.79405100
16Vibrio cholerae infection_Homo sapiens_hsa051101.76822063
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.68244865
18Steroid biosynthesis_Homo sapiens_hsa001001.60237117
19Nitrogen metabolism_Homo sapiens_hsa009101.47489362
20Sulfur metabolism_Homo sapiens_hsa009201.46008122
21Serotonergic synapse_Homo sapiens_hsa047261.41484525
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.33365009
23SNARE interactions in vesicular transport_Homo sapiens_hsa041301.32675470
24Fanconi anemia pathway_Homo sapiens_hsa034601.31720966
25Ether lipid metabolism_Homo sapiens_hsa005651.31392332
26Synaptic vesicle cycle_Homo sapiens_hsa047211.30929709
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.30515374
28Phototransduction_Homo sapiens_hsa047441.23909064
29One carbon pool by folate_Homo sapiens_hsa006701.23722999
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.17733411
31DNA replication_Homo sapiens_hsa030301.16789457
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15462138
33Selenocompound metabolism_Homo sapiens_hsa004501.15321845
34Rheumatoid arthritis_Homo sapiens_hsa053231.12295958
35Tryptophan metabolism_Homo sapiens_hsa003801.09354592
36Peroxisome_Homo sapiens_hsa041461.09190758
37GABAergic synapse_Homo sapiens_hsa047271.07328008
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.04634888
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04209054
40Taste transduction_Homo sapiens_hsa047421.00319375
41Sulfur relay system_Homo sapiens_hsa041220.98265321
42Morphine addiction_Homo sapiens_hsa050320.97669777
43Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.97636740
44Chemical carcinogenesis_Homo sapiens_hsa052040.97515529
45Glutamatergic synapse_Homo sapiens_hsa047240.95095582
46Basal transcription factors_Homo sapiens_hsa030220.92867839
47Caffeine metabolism_Homo sapiens_hsa002320.92320273
48Amphetamine addiction_Homo sapiens_hsa050310.92116308
49Base excision repair_Homo sapiens_hsa034100.89505462
50Pyrimidine metabolism_Homo sapiens_hsa002400.88321103
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87011619
52Circadian entrainment_Homo sapiens_hsa047130.85375131
53Primary bile acid biosynthesis_Homo sapiens_hsa001200.82374001
54Dopaminergic synapse_Homo sapiens_hsa047280.82298891
55Long-term depression_Homo sapiens_hsa047300.81546401
56Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80898864
57Sphingolipid metabolism_Homo sapiens_hsa006000.79999828
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.79653248
59RNA transport_Homo sapiens_hsa030130.75708361
60Metabolic pathways_Homo sapiens_hsa011000.75522373
61Purine metabolism_Homo sapiens_hsa002300.75059838
62beta-Alanine metabolism_Homo sapiens_hsa004100.74799191
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73792129
64Intestinal immune network for IgA production_Homo sapiens_hsa046720.71533147
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.70883095
66Linoleic acid metabolism_Homo sapiens_hsa005910.70344807
67Retinol metabolism_Homo sapiens_hsa008300.69472566
68Arachidonic acid metabolism_Homo sapiens_hsa005900.69185897
69Spliceosome_Homo sapiens_hsa030400.66976304
70Cocaine addiction_Homo sapiens_hsa050300.63733154
71Regulation of autophagy_Homo sapiens_hsa041400.63578035
72Phagosome_Homo sapiens_hsa041450.62734635
73Homologous recombination_Homo sapiens_hsa034400.60349664
74Long-term potentiation_Homo sapiens_hsa047200.58388633
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58265931
76Pyruvate metabolism_Homo sapiens_hsa006200.58238451
77Autoimmune thyroid disease_Homo sapiens_hsa053200.55724017
78Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.54622198
79Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54317012
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52999031
81Olfactory transduction_Homo sapiens_hsa047400.52933871
82Tyrosine metabolism_Homo sapiens_hsa003500.52610804
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51299776
84Calcium signaling pathway_Homo sapiens_hsa040200.51077360
85Glutathione metabolism_Homo sapiens_hsa004800.50650539
86RNA degradation_Homo sapiens_hsa030180.50356883
87Salivary secretion_Homo sapiens_hsa049700.49958573
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49027545
89Cholinergic synapse_Homo sapiens_hsa047250.48843136
90Nucleotide excision repair_Homo sapiens_hsa034200.48359833
91Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.48200375
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48162071
93Vitamin B6 metabolism_Homo sapiens_hsa007500.47871192
94Vitamin digestion and absorption_Homo sapiens_hsa049770.47633053
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47598703
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47178884
97Non-homologous end-joining_Homo sapiens_hsa034500.46639805
98Renin secretion_Homo sapiens_hsa049240.46495280
99Fatty acid degradation_Homo sapiens_hsa000710.46491635
100Axon guidance_Homo sapiens_hsa043600.45210377
101Mineral absorption_Homo sapiens_hsa049780.44919794
102Histidine metabolism_Homo sapiens_hsa003400.44836776
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44794150
104Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.44478439
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43760177
106Drug metabolism - other enzymes_Homo sapiens_hsa009830.43429391
107Alcoholism_Homo sapiens_hsa050340.41690648
108Asthma_Homo sapiens_hsa053100.38272155
109Insulin secretion_Homo sapiens_hsa049110.38054708
110Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36277386
111Arginine and proline metabolism_Homo sapiens_hsa003300.35641919
112Type I diabetes mellitus_Homo sapiens_hsa049400.35299422
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35190070
114Butanoate metabolism_Homo sapiens_hsa006500.33849137
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.32753861
116African trypanosomiasis_Homo sapiens_hsa051430.32632626
117Folate biosynthesis_Homo sapiens_hsa007900.30150845
118Fat digestion and absorption_Homo sapiens_hsa049750.29928126
119Gastric acid secretion_Homo sapiens_hsa049710.29180176
120Propanoate metabolism_Homo sapiens_hsa006400.27733216
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27642093
122Fatty acid metabolism_Homo sapiens_hsa012120.26876381
123Allograft rejection_Homo sapiens_hsa053300.26189666
124Maturity onset diabetes of the young_Homo sapiens_hsa049500.25878509
125Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.23699065
126Glycerolipid metabolism_Homo sapiens_hsa005610.22519743
127Phenylalanine metabolism_Homo sapiens_hsa003600.18695492
128Mismatch repair_Homo sapiens_hsa034300.17563791
129Oxytocin signaling pathway_Homo sapiens_hsa049210.16329956
130Graft-versus-host disease_Homo sapiens_hsa053320.16228326
131Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.14307014
132Pancreatic secretion_Homo sapiens_hsa049720.14298181
133Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.13446825
134Ovarian steroidogenesis_Homo sapiens_hsa049130.13032039
135Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.12283569
136Gap junction_Homo sapiens_hsa045400.11670196

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