MRPS35

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has had confusing nomenclature in the literature. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 3p, 5q, and 10q. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.17510647
2energy coupled proton transport, down electrochemical gradient (GO:0015985)6.67073678
3ATP synthesis coupled proton transport (GO:0015986)6.67073678
4ribosomal small subunit assembly (GO:0000028)5.85260208
5viral transcription (GO:0019083)5.81770943
6translational termination (GO:0006415)5.66375373
7ribosomal small subunit biogenesis (GO:0042274)5.50387371
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.48986955
9respiratory electron transport chain (GO:0022904)5.46812792
10DNA deamination (GO:0045006)5.34961534
11electron transport chain (GO:0022900)5.31897284
12ribosomal large subunit biogenesis (GO:0042273)5.15253164
13maturation of SSU-rRNA (GO:0030490)5.09988540
14oxidative phosphorylation (GO:0006119)4.91751283
15translational elongation (GO:0006414)4.91446662
16SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.89215463
17ribosome assembly (GO:0042255)4.86785477
18cotranslational protein targeting to membrane (GO:0006613)4.84149580
19protein targeting to ER (GO:0045047)4.78810536
20proteasome assembly (GO:0043248)4.61177467
21establishment of protein localization to endoplasmic reticulum (GO:0072599)4.56303139
22protein localization to endoplasmic reticulum (GO:0070972)4.54834793
23viral life cycle (GO:0019058)4.33676989
24cellular protein complex disassembly (GO:0043624)4.33447262
25regulation of mitochondrial translation (GO:0070129)4.25879363
26translational initiation (GO:0006413)4.20577814
27mitochondrial respiratory chain complex I assembly (GO:0032981)4.20138730
28NADH dehydrogenase complex assembly (GO:0010257)4.20138730
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.20138730
30nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.17620222
31ubiquinone biosynthetic process (GO:0006744)4.02552894
32quinone biosynthetic process (GO:1901663)4.02552894
33deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.99043193
34translation (GO:0006412)3.97160418
35anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.79850869
36ribonucleoprotein complex biogenesis (GO:0022613)3.79340417
37protein complex biogenesis (GO:0070271)3.75673473
38aerobic respiration (GO:0009060)3.73039491
39protein complex disassembly (GO:0043241)3.69479690
40telomere maintenance via semi-conservative replication (GO:0032201)3.66099202
41negative regulation of ligase activity (GO:0051352)3.65584215
42negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.65584215
43respiratory chain complex IV assembly (GO:0008535)3.64882559
44mitochondrial respiratory chain complex assembly (GO:0033108)3.62258284
45pseudouridine synthesis (GO:0001522)3.60646897
46tRNA aminoacylation for protein translation (GO:0006418)3.57819297
47macromolecular complex disassembly (GO:0032984)3.56000933
48cullin deneddylation (GO:0010388)3.55623610
49ubiquinone metabolic process (GO:0006743)3.53799100
50amino acid activation (GO:0043038)3.53770381
51tRNA aminoacylation (GO:0043039)3.53770381
52cellular component biogenesis (GO:0044085)3.52758855
53ATP biosynthetic process (GO:0006754)3.52602231
54purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.51056391
55establishment of protein localization to mitochondrial membrane (GO:0090151)3.48617478
56mitotic metaphase plate congression (GO:0007080)3.47572552
57purine nucleoside triphosphate biosynthetic process (GO:0009145)3.47313164
58positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.46375697
59GTP biosynthetic process (GO:0006183)3.45645954
60DNA strand elongation involved in DNA replication (GO:0006271)3.44144432
61termination of RNA polymerase III transcription (GO:0006386)3.43587538
62transcription elongation from RNA polymerase III promoter (GO:0006385)3.43587538
63inner mitochondrial membrane organization (GO:0007007)3.42646348
64ribosome biogenesis (GO:0042254)3.41483538
65polyketide metabolic process (GO:0030638)3.36401619
66doxorubicin metabolic process (GO:0044598)3.36401619
67daunorubicin metabolic process (GO:0044597)3.36401619
68positive regulation of ligase activity (GO:0051351)3.34293825
69rRNA processing (GO:0006364)3.30955789
70purine nucleobase biosynthetic process (GO:0009113)3.30723774
71nucleobase-containing small molecule interconversion (GO:0015949)3.29916994
72protein deneddylation (GO:0000338)3.28670160
73IMP biosynthetic process (GO:0006188)3.28438729
74DNA strand elongation (GO:0022616)3.27456568
75establishment of integrated proviral latency (GO:0075713)3.26287202
76DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.24676262
77intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.24345074
78signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.24345074
79DNA replication initiation (GO:0006270)3.24269872
80maturation of 5.8S rRNA (GO:0000460)3.24214060
81signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.24094361
82signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.24094361
83signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.24094361
84ribonucleoside triphosphate biosynthetic process (GO:0009201)3.21862475
85signal transduction involved in DNA integrity checkpoint (GO:0072401)3.21293184
86signal transduction involved in DNA damage checkpoint (GO:0072422)3.21293184
87folic acid-containing compound biosynthetic process (GO:0009396)3.21037508
88rRNA metabolic process (GO:0016072)3.19474280
89nuclear-transcribed mRNA catabolic process (GO:0000956)3.19236539
90rRNA methylation (GO:0031167)3.17821307
91regulation of ubiquitin-protein transferase activity (GO:0051438)3.16354642
92signal transduction involved in cell cycle checkpoint (GO:0072395)3.16028239
93cellular respiration (GO:0045333)3.15316808
94histone exchange (GO:0043486)3.14325547
95exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.12243924
96regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.11398291
97UTP biosynthetic process (GO:0006228)3.10428534
98telomere maintenance via recombination (GO:0000722)3.10099605
99L-serine metabolic process (GO:0006563)3.09905306
100nucleobase biosynthetic process (GO:0046112)3.09782080
101negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.08824730
102DNA double-strand break processing (GO:0000729)3.08247158
103regulation of ligase activity (GO:0051340)3.07482258
104protein localization to mitochondrion (GO:0070585)3.06693480
105spliceosomal snRNP assembly (GO:0000387)3.06341879
106nuclear pore complex assembly (GO:0051292)3.06097886
107IMP metabolic process (GO:0046040)3.04642223
108protein localization to kinetochore (GO:0034501)3.03466489
109mRNA catabolic process (GO:0006402)3.03269996
110rRNA modification (GO:0000154)3.02558435
111nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.01224967
112ribonucleoprotein complex disassembly (GO:0032988)2.99554552
113regulation of cellular amino acid metabolic process (GO:0006521)2.99415500
114DNA replication checkpoint (GO:0000076)2.99107326
115metaphase plate congression (GO:0051310)2.98432778
116protein targeting to mitochondrion (GO:0006626)2.96615119
117L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.96242114
118protein targeting to membrane (GO:0006612)2.95729824
119establishment of protein localization to mitochondrion (GO:0072655)2.94351414
120quinone metabolic process (GO:1901661)2.94251129
121guanosine-containing compound biosynthetic process (GO:1901070)2.92908999
122formation of translation preinitiation complex (GO:0001731)2.92768046
123mitotic sister chromatid segregation (GO:0000070)2.91998454
124DNA replication-independent nucleosome organization (GO:0034724)2.91525787
125DNA replication-independent nucleosome assembly (GO:0006336)2.91525787
126chromatin remodeling at centromere (GO:0031055)2.90928988
127cytochrome complex assembly (GO:0017004)2.90858953
128CENP-A containing nucleosome assembly (GO:0034080)2.90847658
129UTP metabolic process (GO:0046051)2.90297136
1307-methylguanosine mRNA capping (GO:0006370)2.90107058
131tricarboxylic acid cycle (GO:0006099)2.88582426
132double-strand break repair via nonhomologous end joining (GO:0006303)2.88207000
133non-recombinational repair (GO:0000726)2.88207000
134mitochondrial RNA metabolic process (GO:0000959)2.87139219
135telomere maintenance via telomere lengthening (GO:0010833)2.87044968
136nuclear pore organization (GO:0006999)2.86473086
137RNA catabolic process (GO:0006401)2.85522501
138pteridine-containing compound biosynthetic process (GO:0042559)2.84612353
139pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.83663004
140chaperone-mediated protein transport (GO:0072321)2.83552103
141positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.83351480
142RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.81645116
143tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.81645116
144deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.81574568
145mitotic recombination (GO:0006312)2.81373527
1467-methylguanosine RNA capping (GO:0009452)2.80945088
147RNA capping (GO:0036260)2.80945088
148establishment of viral latency (GO:0019043)2.79738810
149regulation of translational fidelity (GO:0006450)2.79188503
150pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.79149367
151regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.78399105
152protein localization to chromosome, centromeric region (GO:0071459)2.78219596
153spliceosomal complex assembly (GO:0000245)2.77826497
154nucleoside triphosphate biosynthetic process (GO:0009142)2.77126285
155mitochondrial transport (GO:0006839)2.76621973
156DNA catabolic process, exonucleolytic (GO:0000738)2.75805734
157tRNA metabolic process (GO:0006399)2.75605307
158cell cycle G1/S phase transition (GO:0044843)2.72319061
159G1/S transition of mitotic cell cycle (GO:0000082)2.72319061
160transcription from mitochondrial promoter (GO:0006390)2.72127876

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.59280383
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.59188718
3E2F7_22180533_ChIP-Seq_HELA_Human4.56989700
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.92062196
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.89121054
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.87051682
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.80349852
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.78229707
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.54371105
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.46044228
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.23458999
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.07942924
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.05324443
14CREB1_15753290_ChIP-ChIP_HEK293T_Human3.05224915
15ELF1_17652178_ChIP-ChIP_JURKAT_Human3.00837885
16* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.97591157
17* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.89599850
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.80128507
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.79640914
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.78402408
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.75742786
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.60696241
23VDR_23849224_ChIP-Seq_CD4+_Human2.49386469
24E2F1_18555785_ChIP-Seq_MESCs_Mouse2.46006658
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.44238834
26SRF_21415370_ChIP-Seq_HL-1_Mouse2.43176231
27XRN2_22483619_ChIP-Seq_HELA_Human2.34952756
28PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.28195617
29YY1_21170310_ChIP-Seq_MESCs_Mouse2.28169932
30DCP1A_22483619_ChIP-Seq_HELA_Human2.27414912
31NELFA_20434984_ChIP-Seq_ESCs_Mouse2.20951534
32FOXP3_21729870_ChIP-Seq_TREG_Human2.15088022
33TTF2_22483619_ChIP-Seq_HELA_Human2.13374713
34* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.97694112
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.95603691
36* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.91302368
37* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.89504175
38ELK1_19687146_ChIP-ChIP_HELA_Human1.84824640
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.82277448
40GABP_19822575_ChIP-Seq_HepG2_Human1.79819314
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.78168922
42* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.74185026
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.72470743
44* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.67195544
45PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.66152774
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.57728517
47CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.56757863
48CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.54871046
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.54149527
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.54126888
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51061873
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.50620040
53ERG_20887958_ChIP-Seq_HPC-7_Mouse1.50261923
54* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47485236
55* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47456042
56MYC_18940864_ChIP-ChIP_HL60_Human1.46761694
57MYCN_18555785_ChIP-Seq_MESCs_Mouse1.45651399
58HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.44595561
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.43343435
60IRF1_19129219_ChIP-ChIP_H3396_Human1.41764741
61* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.40490832
62FOXM1_23109430_ChIP-Seq_U2OS_Human1.35934416
63AR_21909140_ChIP-Seq_LNCAP_Human1.35649037
64SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.31531385
65ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.29898744
66ELK1_22589737_ChIP-Seq_MCF10A_Human1.27995350
67CIITA_25753668_ChIP-Seq_RAJI_Human1.26257322
68ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.25592388
69CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24509610
70* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.23876345
71ZNF263_19887448_ChIP-Seq_K562_Human1.22086851
72BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.20845707
73E2F1_21310950_ChIP-Seq_MCF-7_Human1.19335620
74TFEB_21752829_ChIP-Seq_HELA_Human1.16010611
75EGR1_23403033_ChIP-Seq_LIVER_Mouse1.14728044
76CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.13465698
77KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11825155
78STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11428648
79CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11269303
80SALL1_21062744_ChIP-ChIP_HESCs_Human1.11220984
81TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.11024606
82PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10601076
83CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.05056017
84* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04706878
85ELF5_23300383_ChIP-Seq_T47D_Human1.03443507
86SOX2_18555785_ChIP-Seq_MESCs_Mouse1.03124246
87RBPJ_22232070_ChIP-Seq_NCS_Mouse1.03042805
88KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00817639
89SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99599526
90CTCF_18555785_ChIP-Seq_MESCs_Mouse0.94475342
91SOX17_20123909_ChIP-Seq_XEN_Mouse0.93649015
92RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91134337
93TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90347821
94GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88559818
95KDM5A_27292631_Chip-Seq_BREAST_Human0.87749701
96DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87696012
97* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.85404905
98NANOG_16153702_ChIP-ChIP_HESCs_Human0.85261162
99EWS_26573619_Chip-Seq_HEK293_Human0.84465965
100CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.84026315
101CHD1_26751641_Chip-Seq_LNCaP_Human0.83418980
102CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.82471443
103DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.80692975
104CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.80642756
105RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.79213961
106ESR1_15608294_ChIP-ChIP_MCF-7_Human0.78494462
107* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.78218930
108TBX5_21415370_ChIP-Seq_HL-1_Mouse0.74218796
109HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.73558567
110SOX2_18692474_ChIP-Seq_MEFs_Mouse0.73288328
111NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.71209019
112FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.70152515
113OCT4_18692474_ChIP-Seq_MEFs_Mouse0.67028706
114POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.66198704
115SPI1_23547873_ChIP-Seq_NB4_Human0.65391234
116GATA4_21415370_ChIP-Seq_HL-1_Mouse0.63852024
117POU5F1_16153702_ChIP-ChIP_HESCs_Human0.63236428
118TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.62692091
119TP63_19390658_ChIP-ChIP_HaCaT_Human0.61894746
120MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.61571328
121YY1_22570637_ChIP-Seq_MALME-3M_Human0.61135759

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.49274288
2MP0003693_abnormal_embryo_hatching3.65381774
3MP0003806_abnormal_nucleotide_metabolis3.26856743
4MP0006036_abnormal_mitochondrial_physio3.14006623
5MP0010234_abnormal_vibrissa_follicle3.01606761
6MP0004957_abnormal_blastocyst_morpholog2.88256415
7MP0003646_muscle_fatigue2.74666037
8MP0010094_abnormal_chromosome_stability2.57212002
9MP0006035_abnormal_mitochondrial_morpho2.49697237
10MP0008058_abnormal_DNA_repair2.40112945
11MP0003136_yellow_coat_color2.34141253
12MP0004215_abnormal_myocardial_fiber2.27493581
13MP0003186_abnormal_redox_activity2.26554781
14MP0002102_abnormal_ear_morphology2.24565777
15MP0003111_abnormal_nucleus_morphology2.15111511
16MP0008057_abnormal_DNA_replication2.09302901
17MP0004147_increased_porphyrin_level2.05611558
18MP0004381_abnormal_hair_follicle1.99601083
19MP0008932_abnormal_embryonic_tissue1.99037304
20MP0005330_cardiomyopathy1.98103600
21MP0005360_urolithiasis1.91335614
22MP0006292_abnormal_olfactory_placode1.90969505
23MP0003077_abnormal_cell_cycle1.88796836
24MP0002139_abnormal_hepatobiliary_system1.87753004
25MP0005085_abnormal_gallbladder_physiolo1.86364267
26MP0003718_maternal_effect1.85261939
27MP0010352_gastrointestinal_tract_polyps1.83668778
28MP0001188_hyperpigmentation1.74590450
29MP0003221_abnormal_cardiomyocyte_apopto1.72953347
30MP0003567_abnormal_fetal_cardiomyocyte1.69247686
31MP0002837_dystrophic_cardiac_calcinosis1.68213245
32MP0002132_abnormal_respiratory_system1.67688682
33MP0005075_abnormal_melanosome_morpholog1.67524272
34MP0000372_irregular_coat_pigmentation1.64439892
35MP0000350_abnormal_cell_proliferation1.61711288
36MP0005451_abnormal_body_composition1.60854935
37MP0002396_abnormal_hematopoietic_system1.55141603
38MP0005332_abnormal_amino_acid1.54012350
39MP0005409_darkened_coat_color1.51146424
40MP0000566_synostosis1.50738468
41MP0004084_abnormal_cardiac_muscle1.49886169
42MP0005408_hypopigmentation1.48599587
43MP0001697_abnormal_embryo_size1.43977761
44MP0001661_extended_life_span1.42671609
45MP0001764_abnormal_homeostasis1.41620405
46MP0000749_muscle_degeneration1.41471907
47MP0000490_abnormal_crypts_of1.39398378
48MP0003137_abnormal_impulse_conducting1.39278349
49MP0001529_abnormal_vocalization1.33553284
50MP0005174_abnormal_tail_pigmentation1.31543378
51MP0004233_abnormal_muscle_weight1.30896450
52MP0001672_abnormal_embryogenesis/_devel1.30728927
53MP0005380_embryogenesis_phenotype1.30728927
54MP0005377_hearing/vestibular/ear_phenot1.28980712
55MP0003878_abnormal_ear_physiology1.28980712
56MP0003941_abnormal_skin_development1.26998859
57MP0008875_abnormal_xenobiotic_pharmacok1.24422391
58MP0002080_prenatal_lethality1.23779990
59MP0009697_abnormal_copulation1.22334926
60MP0005670_abnormal_white_adipose1.20491619
61MP0003123_paternal_imprinting1.19918037
62MP0003315_abnormal_perineum_morphology1.19295827
63MP0002127_abnormal_cardiovascular_syste1.17260501
64MP0002160_abnormal_reproductive_system1.15485173
65MP0002938_white_spotting1.14986586
66MP0001727_abnormal_embryo_implantation1.14029902
67MP0003984_embryonic_growth_retardation1.12699707
68MP0003786_premature_aging1.12678420
69MP0008995_early_reproductive_senescence1.12206840
70MP0001485_abnormal_pinna_reflex1.10383352
71MP0002088_abnormal_embryonic_growth/wei1.10014601
72MP0003011_delayed_dark_adaptation1.09398872
73MP0005266_abnormal_metabolism1.08800657
74MP0005379_endocrine/exocrine_gland_phen1.08036232
75MP0010307_abnormal_tumor_latency1.07276829
76MP0005365_abnormal_bile_salt1.06412003
77MP0004036_abnormal_muscle_relaxation1.04151278
78MP0000647_abnormal_sebaceous_gland1.04126899
79MP0000049_abnormal_middle_ear1.03986840
80MP0008775_abnormal_heart_ventricle1.01798549
81MP0001881_abnormal_mammary_gland1.01404555
82MP0008007_abnormal_cellular_replicative1.00762559
83MP0002269_muscular_atrophy0.99942689
84MP0002163_abnormal_gland_morphology0.99614905
85MP0000751_myopathy0.99533737
86MP0004019_abnormal_vitamin_homeostasis0.99193097
87MP0004142_abnormal_muscle_tone0.95800953
88MP0002084_abnormal_developmental_patter0.95399512
89MP0009672_abnormal_birth_weight0.94820028
90MP0005395_other_phenotype0.94678317
91MP0004145_abnormal_muscle_electrophysio0.94096434
92MP0002090_abnormal_vision0.93748366
93MP0002085_abnormal_embryonic_tissue0.92904709
94MP0003828_pulmonary_edema0.92533363
95MP0005636_abnormal_mineral_homeostasis0.92316790
96MP0008877_abnormal_DNA_methylation0.92287009
97MP0008789_abnormal_olfactory_epithelium0.89568249
98MP0001853_heart_inflammation0.89377383
99MP0003937_abnormal_limbs/digits/tail_de0.88560986
100MP0005385_cardiovascular_system_phenoty0.86965568
101MP0001544_abnormal_cardiovascular_syste0.86965568
102MP0000516_abnormal_urinary_system0.85914911
103MP0005367_renal/urinary_system_phenotyp0.85914911
104MP0003195_calcinosis0.84708895
105MP0001929_abnormal_gametogenesis0.84204248
106MP0002877_abnormal_melanocyte_morpholog0.83552602
107MP0002210_abnormal_sex_determination0.82453972
108MP0000750_abnormal_muscle_regeneration0.81123269
109MP0002972_abnormal_cardiac_muscle0.80984270
110MP0004133_heterotaxia0.80431007
111MP0000747_muscle_weakness0.80126074
112MP0005389_reproductive_system_phenotype0.79419288
113MP0004197_abnormal_fetal_growth/weight/0.79391120
114MP0002796_impaired_skin_barrier0.79231878
115MP0003938_abnormal_ear_development0.79086160
116MP0004484_altered_response_of0.78098421
117MP0001293_anophthalmia0.76266317
118MP0005319_abnormal_enzyme/_coenzyme0.75975163
119MP0002086_abnormal_extraembryonic_tissu0.75925383
120MP0001346_abnormal_lacrimal_gland0.75591978
121MP0006138_congestive_heart_failure0.74243999
122MP0002249_abnormal_larynx_morphology0.73193237
123MP0002095_abnormal_skin_pigmentation0.72811650
124MP0005187_abnormal_penis_morphology0.72590928
125MP0000627_abnormal_mammary_gland0.72440944
126MP0001145_abnormal_male_reproductive0.72099445
127MP0004043_abnormal_pH_regulation0.71651152
128MP0010630_abnormal_cardiac_muscle0.71600819
129MP0000653_abnormal_sex_gland0.70795286
130MP0009703_decreased_birth_body0.70566846
131MP0002332_abnormal_exercise_endurance0.70544170
132MP0000313_abnormal_cell_death0.70051585
133MP0006072_abnormal_retinal_apoptosis0.69703521
134MP0001919_abnormal_reproductive_system0.69423507
135MP0005376_homeostasis/metabolism_phenot0.68398294
136MP0003868_abnormal_feces_composition0.68215226
137MP0009643_abnormal_urine_homeostasis0.67723816
138MP0005584_abnormal_enzyme/coenzyme_acti0.66260321
139MP0002166_altered_tumor_susceptibility0.66227609
140MP0001730_embryonic_growth_arrest0.65798596
141MP0001666_abnormal_nutrient_absorption0.65476676
142MP0005501_abnormal_skin_physiology0.65364090
143MP0005384_cellular_phenotype0.65270086
144MP0000358_abnormal_cell_content/0.64505188
145MP0003763_abnormal_thymus_physiology0.61012539
146MP0009333_abnormal_splenocyte_physiolog0.60136218
147MP0005666_abnormal_adipose_tissue0.59961508
148MP0001905_abnormal_dopamine_level0.58918787
149MP0000678_abnormal_parathyroid_gland0.58104390
150MP0002638_abnormal_pupillary_reflex0.57909588

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.62585441
2Abnormal mitochondria in muscle tissue (HP:0008316)5.23245886
3Mitochondrial inheritance (HP:0001427)5.19321894
4Hepatic necrosis (HP:0002605)5.10944525
5Hepatocellular necrosis (HP:0001404)5.07926178
6Acute encephalopathy (HP:0006846)4.99783618
7Increased CSF lactate (HP:0002490)4.77237228
8Reticulocytopenia (HP:0001896)4.68969769
9Progressive macrocephaly (HP:0004481)4.56973987
10Increased hepatocellular lipid droplets (HP:0006565)4.37236880
11Abnormality of cells of the erythroid lineage (HP:0012130)4.30222317
12Lipid accumulation in hepatocytes (HP:0006561)4.27928617
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.22728441
14Decreased activity of mitochondrial respiratory chain (HP:0008972)4.22728441
15Abnormal number of erythroid precursors (HP:0012131)4.13737262
16Cerebral edema (HP:0002181)4.11160848
17Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.92480394
18Increased serum lactate (HP:0002151)3.89181134
19Lactic acidosis (HP:0003128)3.75997520
20Increased intramyocellular lipid droplets (HP:0012240)3.62477182
21Macrocytic anemia (HP:0001972)3.57669052
22Increased serum pyruvate (HP:0003542)3.57350729
23Abnormality of glycolysis (HP:0004366)3.57350729
24Abnormality of methionine metabolism (HP:0010901)3.53362386
25Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.51080471
26Exercise intolerance (HP:0003546)3.49367390
27Renal Fanconi syndrome (HP:0001994)3.43694454
28Increased muscle lipid content (HP:0009058)3.41969127
29Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.38617155
30Abnormality of alanine metabolism (HP:0010916)3.38617155
31Hyperalaninemia (HP:0003348)3.38617155
32Respiratory failure (HP:0002878)3.34658231
333-Methylglutaconic aciduria (HP:0003535)3.30315443
34Dicarboxylic aciduria (HP:0003215)3.25019866
35Abnormality of dicarboxylic acid metabolism (HP:0010995)3.25019866
36Exertional dyspnea (HP:0002875)3.01884485
37Pallor (HP:0000980)3.00239243
38Lethargy (HP:0001254)2.86381464
39Glycosuria (HP:0003076)2.78064335
40Abnormality of urine glucose concentration (HP:0011016)2.78064335
41Respiratory difficulties (HP:0002880)2.77007442
42Microvesicular hepatic steatosis (HP:0001414)2.75874857
43Optic disc pallor (HP:0000543)2.75378504
44Abnormality of aspartate family amino acid metabolism (HP:0010899)2.70610291
45Generalized aminoaciduria (HP:0002909)2.67400661
46Birth length less than 3rd percentile (HP:0003561)2.65501566
47Neoplasm of the adrenal gland (HP:0100631)2.63415923
48Methylmalonic aciduria (HP:0012120)2.57203911
49Nausea (HP:0002018)2.55449292
50Aplasia/Hypoplasia of the sacrum (HP:0008517)2.55080875
51Hyperglycinemia (HP:0002154)2.54735081
52Leukodystrophy (HP:0002415)2.49897141
53CNS demyelination (HP:0007305)2.45344957
54Abnormality of serum amino acid levels (HP:0003112)2.45282298
55Type I transferrin isoform profile (HP:0003642)2.45281777
56Hyperglycinuria (HP:0003108)2.43387737
57Abnormality of renal resorption (HP:0011038)2.36550015
58Abnormality of glycine metabolism (HP:0010895)2.34946923
59Abnormality of serine family amino acid metabolism (HP:0010894)2.34946923
60Abnormality of fatty-acid metabolism (HP:0004359)2.32143538
61Oral leukoplakia (HP:0002745)2.31136694
62Renal cortical cysts (HP:0000803)2.30643899
63Exercise-induced muscle cramps (HP:0003710)2.29965850
64Hyperammonemia (HP:0001987)2.29160690
65Sparse eyelashes (HP:0000653)2.28818320
66Methylmalonic acidemia (HP:0002912)2.26569895
67Ragged-red muscle fibers (HP:0003200)2.26095069
68Abnormality of the anterior horn cell (HP:0006802)2.25622419
69Degeneration of anterior horn cells (HP:0002398)2.25622419
70Abnormality of the heme biosynthetic pathway (HP:0010472)2.23430869
71Progressive external ophthalmoplegia (HP:0000590)2.20795157
72Abnormality of the axillary hair (HP:0100134)2.18329834
73Abnormality of secondary sexual hair (HP:0009888)2.18329834
74Amniotic constriction ring (HP:0009775)2.17749691
75Abnormality of placental membranes (HP:0011409)2.17749691
76Rhabdomyolysis (HP:0003201)2.15242157
77Reduced antithrombin III activity (HP:0001976)2.12734159
78Aplastic anemia (HP:0001915)2.12392356
79Proximal tubulopathy (HP:0000114)2.11277656
80Gout (HP:0001997)2.09339734
81Progressive muscle weakness (HP:0003323)2.07332663
82Vomiting (HP:0002013)2.06475730
83Abnormal gallbladder physiology (HP:0012438)2.05991970
84Cholecystitis (HP:0001082)2.05991970
85Abnormality of aromatic amino acid family metabolism (HP:0004338)2.05839126
86Hypoglycemic coma (HP:0001325)2.05532733
87Palpitations (HP:0001962)2.04032588
88Metabolic acidosis (HP:0001942)2.01941461
89Abnormality of the preputium (HP:0100587)2.01630293
90Hyperphosphaturia (HP:0003109)1.99300544
91Neuroendocrine neoplasm (HP:0100634)1.98961145
92Emotional lability (HP:0000712)1.98379844
93Abnormality of sulfur amino acid metabolism (HP:0004339)1.98224625
94Abnormality of pyrimidine metabolism (HP:0004353)1.98162865
95Multiple enchondromatosis (HP:0005701)1.97595463
96Abnormal protein glycosylation (HP:0012346)1.96716939
97Abnormal glycosylation (HP:0012345)1.96716939
98Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.96716939
99Abnormal protein N-linked glycosylation (HP:0012347)1.96716939
100Pancytopenia (HP:0001876)1.93248364
101Gliosis (HP:0002171)1.91568936
102Abnormal lung lobation (HP:0002101)1.90717119
103Breast hypoplasia (HP:0003187)1.87198766
104Abnormality of chromosome stability (HP:0003220)1.85601454
105Neoplasm of the peripheral nervous system (HP:0100007)1.85206484
106Chromosomal breakage induced by crosslinking agents (HP:0003221)1.81080173
107Abnormality of the labia minora (HP:0012880)1.80687401
108Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.80225358
109Abnormality of the vitamin B12 metabolism (HP:0004341)1.80166865
110Abnormal urine phosphate concentration (HP:0012599)1.80124825
111Hypobetalipoproteinemia (HP:0003563)1.78656585
112Chromsome breakage (HP:0040012)1.78353852
113Spastic paraparesis (HP:0002313)1.78166093
114Abnormalities of placenta or umbilical cord (HP:0001194)1.77231416
115Neoplasm of the colon (HP:0100273)1.76646014
116Pheochromocytoma (HP:0002666)1.76627512
117Ketosis (HP:0001946)1.76351503
118Colon cancer (HP:0003003)1.75796854
119Nemaline bodies (HP:0003798)1.75506758
120Pancreatic islet-cell hyperplasia (HP:0004510)1.75400454
121Triphalangeal thumb (HP:0001199)1.75344567
122Abnormal hemoglobin (HP:0011902)1.73984628
123Poor suck (HP:0002033)1.73889932
124Abnormality of reticulocytes (HP:0004312)1.73824127
125Conjunctival hamartoma (HP:0100780)1.72117465
126Megaloblastic anemia (HP:0001889)1.71668267
127Rhabdomyosarcoma (HP:0002859)1.69677816
128Aplasia/hypoplasia of the uterus (HP:0008684)1.69166547
129Adrenal hypoplasia (HP:0000835)1.68460077
130Cerebral hypomyelination (HP:0006808)1.67517489
131Microretrognathia (HP:0000308)1.66695784
132Ketoacidosis (HP:0001993)1.66671724
133Abnormality of vitamin B metabolism (HP:0004340)1.65506898
134Congenital, generalized hypertrichosis (HP:0004540)1.65335244
135Ventricular tachycardia (HP:0004756)1.59338844
136Absent thumb (HP:0009777)1.57799702
137Myoglobinuria (HP:0002913)1.57348864
138Renal tubular dysfunction (HP:0000124)1.55549641

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.77935505
2NME23.77348158
3BUB13.52257650
4WEE13.35716526
5TLK13.33084344
6BCKDK3.07493769
7SRPK12.84620546
8TNIK2.63943072
9EIF2AK12.63053179
10VRK12.59970004
11VRK22.42920401
12TRIM282.35489264
13NME12.21572668
14BRSK21.82205293
15BCR1.79712764
16NUAK11.78764628
17MKNK21.76979267
18PBK1.75379363
19ERBB31.74833948
20CDC71.74327319
21MAP3K121.72960643
22MYLK1.61714864
23MKNK11.61609329
24ZAK1.61320342
25EIF2AK31.57001765
26TTK1.56261532
27MST1R1.54210939
28SCYL21.53314130
29MAP4K21.52420690
30DYRK31.51434726
31MUSK1.45146491
32OBSCN1.44317206
33IRAK31.41245097
34FLT31.39120591
35ACVR1B1.30563124
36KDR1.29925698
37PAK41.24831797
38TAF11.18546259
39GRK71.13133905
40CSNK1G31.12485387
41PIM21.10580952
42PLK11.10427598
43AURKA1.08493681
44CDK71.07760328
45AURKB1.06768721
46MST41.06709404
47CSNK1G11.05138431
48STK241.04786673
49BMPR1B1.03049432
50EIF2AK21.02745333
51RPS6KB20.96751925
52BMPR20.96408206
53DYRK20.95952211
54LIMK10.94389184
55CSNK1G20.94270055
56CSNK1A1L0.93383330
57TEC0.92464454
58PLK40.91461329
59TIE10.86518312
60CDK80.84412930
61MAP3K110.82328749
62STK40.82111770
63CSNK2A10.81974442
64ERBB40.81314943
65CSNK2A20.78478835
66PINK10.78405480
67CLK10.78385324
68BLK0.78317272
69NLK0.76890150
70ABL20.76694700
71ATR0.75917415
72GRK10.75166539
73WNK30.75151367
74CHEK20.74161076
75TESK20.73587700
76PIK3CA0.71261359
77RPS6KA50.70993516
78CDK40.70755041
79PHKG10.70504294
80PHKG20.70504294
81PDK40.69309481
82PDK30.69309481
83WNK40.67620515
84DAPK10.67570851
85YES10.65549302
86STK390.64737319
87CHEK10.63860719
88SIK30.63692140
89STK30.62015143
90PLK30.61956172
91BRAF0.60558935
92MAPK150.59695317
93ARAF0.58552669
94EPHA20.57539135
95PLK20.57392133
96ADRBK20.56112995
97MET0.55853770
98TGFBR10.55333823
99TESK10.54940298
100MAP2K60.54820752
101RAF10.54170638
102CASK0.53571024
103KIT0.53510415
104AKT20.53457116
105ILK0.50660849
106TSSK60.48339946
107NEK20.48231768
108CSNK1E0.47813783
109BTK0.47744991
110CDK190.47710917
111RPS6KA40.46734257
112ALK0.44106842
113BRSK10.43289656
114MAPK40.43036313
115PRKCI0.42797860
116NEK10.42390125
117ATM0.41057430
118CCNB10.37397689
119MAPKAPK50.36983645
120CAMK2D0.36715231
121PASK0.35043874
122CAMK2G0.34673579
123MINK10.34162072
124PAK10.33871469
125DMPK0.33542655
126LYN0.33371661
127IRAK40.33061104
128CDK10.32910429
129MAP3K90.31497240
130DAPK30.30822197
131MAP4K10.30252273
132STK38L0.29842786
133CDK180.29433882
134MAP3K80.28712154
135STK100.28432714
136PRKACA0.28070905
137CDK140.26831025
138PDK20.26808690
139OXSR10.24612978

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.61294290
2Oxidative phosphorylation_Homo sapiens_hsa001903.86807238
3Parkinsons disease_Homo sapiens_hsa050123.53050051
4Proteasome_Homo sapiens_hsa030503.04011031
5DNA replication_Homo sapiens_hsa030303.03014293
6RNA polymerase_Homo sapiens_hsa030202.70805420
7Mismatch repair_Homo sapiens_hsa034302.62492134
8Huntingtons disease_Homo sapiens_hsa050162.58960254
9Alzheimers disease_Homo sapiens_hsa050102.45829430
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.32595352
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.27927456
12Pyrimidine metabolism_Homo sapiens_hsa002402.20702769
13Homologous recombination_Homo sapiens_hsa034402.20663175
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.00639021
15Propanoate metabolism_Homo sapiens_hsa006401.91415986
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.85064375
17Spliceosome_Homo sapiens_hsa030401.83078948
18Nucleotide excision repair_Homo sapiens_hsa034201.80786403
19One carbon pool by folate_Homo sapiens_hsa006701.77738185
20Base excision repair_Homo sapiens_hsa034101.71511844
21Protein export_Homo sapiens_hsa030601.70246419
22Cardiac muscle contraction_Homo sapiens_hsa042601.69804684
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.64054581
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.59210235
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.56977342
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.56389889
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.53900492
28Folate biosynthesis_Homo sapiens_hsa007901.44050298
29Sulfur relay system_Homo sapiens_hsa041221.39607277
30Fanconi anemia pathway_Homo sapiens_hsa034601.37761857
31Carbon metabolism_Homo sapiens_hsa012001.35755136
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.34506213
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.33021517
34Fatty acid degradation_Homo sapiens_hsa000711.32309527
35Fatty acid elongation_Homo sapiens_hsa000621.27852348
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.22269281
37Non-homologous end-joining_Homo sapiens_hsa034501.22168881
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.21711932
39Purine metabolism_Homo sapiens_hsa002301.16627401
40Glutathione metabolism_Homo sapiens_hsa004801.16468451
41Pyruvate metabolism_Homo sapiens_hsa006201.15454107
42RNA degradation_Homo sapiens_hsa030181.14757368
43RNA transport_Homo sapiens_hsa030131.14556750
44Basal transcription factors_Homo sapiens_hsa030221.10455238
45Peroxisome_Homo sapiens_hsa041461.09101906
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.07180936
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.04034392
48beta-Alanine metabolism_Homo sapiens_hsa004100.98281687
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97441859
50Metabolic pathways_Homo sapiens_hsa011000.96469822
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95211163
52Butanoate metabolism_Homo sapiens_hsa006500.92470259
53Pentose phosphate pathway_Homo sapiens_hsa000300.92052204
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.89503787
55Pentose and glucuronate interconversions_Homo sapiens_hsa000400.88774224
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.84500961
57Biosynthesis of amino acids_Homo sapiens_hsa012300.82599780
58Fatty acid metabolism_Homo sapiens_hsa012120.81487767
59Sulfur metabolism_Homo sapiens_hsa009200.81020201
60Cell cycle_Homo sapiens_hsa041100.80824817
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78754246
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.78054279
63Arginine biosynthesis_Homo sapiens_hsa002200.77845911
64Arginine and proline metabolism_Homo sapiens_hsa003300.77233971
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76248491
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75389647
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74206431
68Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73071511
69Selenocompound metabolism_Homo sapiens_hsa004500.71853082
70Histidine metabolism_Homo sapiens_hsa003400.70211239
71Arachidonic acid metabolism_Homo sapiens_hsa005900.69059947
72Retinol metabolism_Homo sapiens_hsa008300.65127617
73Chemical carcinogenesis_Homo sapiens_hsa052040.64759373
74Tryptophan metabolism_Homo sapiens_hsa003800.64576693
75Systemic lupus erythematosus_Homo sapiens_hsa053220.63856837
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62875490
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61473337
78Oocyte meiosis_Homo sapiens_hsa041140.60612412
79Tyrosine metabolism_Homo sapiens_hsa003500.59211995
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58955947
81N-Glycan biosynthesis_Homo sapiens_hsa005100.51447873
82Caffeine metabolism_Homo sapiens_hsa002320.50886211
83Phenylalanine metabolism_Homo sapiens_hsa003600.50639218
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.49421653
85p53 signaling pathway_Homo sapiens_hsa041150.46835481
86Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46520111
87Linoleic acid metabolism_Homo sapiens_hsa005910.44287841
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43185224
89Galactose metabolism_Homo sapiens_hsa000520.40182152
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.39735688
91Vitamin digestion and absorption_Homo sapiens_hsa049770.36704265
92Fructose and mannose metabolism_Homo sapiens_hsa000510.32203847
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.30903710
94PPAR signaling pathway_Homo sapiens_hsa033200.30645190
95Thyroid cancer_Homo sapiens_hsa052160.29388859
96Vitamin B6 metabolism_Homo sapiens_hsa007500.29135689
97Starch and sucrose metabolism_Homo sapiens_hsa005000.27822053
98Vibrio cholerae infection_Homo sapiens_hsa051100.27722905
99mRNA surveillance pathway_Homo sapiens_hsa030150.26508693
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.25966181
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25851285
102Herpes simplex infection_Homo sapiens_hsa051680.18079208
103Epstein-Barr virus infection_Homo sapiens_hsa051690.17799774
104Fat digestion and absorption_Homo sapiens_hsa049750.17045801
105Other glycan degradation_Homo sapiens_hsa005110.15035732
106Regulation of autophagy_Homo sapiens_hsa041400.12613149
107Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.12388673
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.11871803
109Primary immunodeficiency_Homo sapiens_hsa053400.11540032
110Steroid biosynthesis_Homo sapiens_hsa001000.09985566
111Fatty acid biosynthesis_Homo sapiens_hsa000610.08712988
112Ether lipid metabolism_Homo sapiens_hsa005650.08597330
113Sphingolipid metabolism_Homo sapiens_hsa006000.04176284

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