MRPS5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S5P family. Pseudogenes corresponding to this gene are found on chromosomes 4q, 5q, and 18q. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)5.76566020
2viral transcription (GO:0019083)5.12699176
3translational termination (GO:0006415)4.93115583
4regulation of mitochondrial translation (GO:0070129)4.90205553
5ribosomal small subunit biogenesis (GO:0042274)4.82323431
6ribosomal large subunit biogenesis (GO:0042273)4.61306674
7ribosomal small subunit assembly (GO:0000028)4.55840452
8translational elongation (GO:0006414)4.32773173
9protein complex biogenesis (GO:0070271)4.23058734
10formation of translation preinitiation complex (GO:0001731)4.20299937
11DNA strand elongation involved in DNA replication (GO:0006271)4.18348677
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.18151866
13translational initiation (GO:0006413)4.17446972
14DNA unwinding involved in DNA replication (GO:0006268)4.11996843
15mitochondrial respiratory chain complex assembly (GO:0033108)4.11174946
16mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.10829757
17mitochondrial respiratory chain complex I assembly (GO:0032981)4.10829757
18NADH dehydrogenase complex assembly (GO:0010257)4.10829757
19DNA replication initiation (GO:0006270)4.10689107
20nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.06462476
21SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.98453398
22spliceosomal snRNP assembly (GO:0000387)3.96280343
23mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.94461700
24DNA strand elongation (GO:0022616)3.94022907
25cotranslational protein targeting to membrane (GO:0006613)3.93721800
26cellular protein complex disassembly (GO:0043624)3.93232629
27ribonucleoprotein complex biogenesis (GO:0022613)3.93041430
28protein targeting to ER (GO:0045047)3.90034355
29telomere maintenance via semi-conservative replication (GO:0032201)3.87739462
30respiratory chain complex IV assembly (GO:0008535)3.87417226
31kynurenine metabolic process (GO:0070189)3.83711839
32tryptophan catabolic process (GO:0006569)3.79395133
33indole-containing compound catabolic process (GO:0042436)3.79395133
34indolalkylamine catabolic process (GO:0046218)3.79395133
35folic acid-containing compound biosynthetic process (GO:0009396)3.79338986
36indolalkylamine metabolic process (GO:0006586)3.78693449
37nucleobase biosynthetic process (GO:0046112)3.78062468
38respiratory electron transport chain (GO:0022904)3.77613835
39viral life cycle (GO:0019058)3.77133417
40establishment of integrated proviral latency (GO:0075713)3.73292120
41electron transport chain (GO:0022900)3.71156304
42L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.70915873
43establishment of protein localization to endoplasmic reticulum (GO:0072599)3.70391855
44cytochrome complex assembly (GO:0017004)3.67009435
45protein localization to endoplasmic reticulum (GO:0070972)3.65016856
46rRNA processing (GO:0006364)3.59078133
47peptidyl-arginine omega-N-methylation (GO:0035247)3.58553402
48protein complex disassembly (GO:0043241)3.57702502
49regulation of telomere maintenance via telomerase (GO:0032210)3.54869593
50spliceosomal complex assembly (GO:0000245)3.53312477
51establishment of protein localization to mitochondrial membrane (GO:0090151)3.51823492
52replication fork processing (GO:0031297)3.47648066
53rRNA metabolic process (GO:0016072)3.46172745
54DNA replication checkpoint (GO:0000076)3.45270209
55energy coupled proton transport, down electrochemical gradient (GO:0015985)3.45064451
56ATP synthesis coupled proton transport (GO:0015986)3.45064451
57* translation (GO:0006412)3.44909868
58histone arginine methylation (GO:0034969)3.44440670
59purine nucleobase biosynthetic process (GO:0009113)3.42410093
60macromolecular complex disassembly (GO:0032984)3.39373749
61signal peptide processing (GO:0006465)3.39068681
62ribosome biogenesis (GO:0042254)3.38629056
63cellular ketone body metabolic process (GO:0046950)3.37366925
64cellular component biogenesis (GO:0044085)3.36513560
65DNA replication-dependent nucleosome assembly (GO:0006335)3.33905871
66DNA replication-dependent nucleosome organization (GO:0034723)3.33905871
67peptidyl-histidine modification (GO:0018202)3.33422758
68viral mRNA export from host cell nucleus (GO:0046784)3.32820333
69somatic diversification of immune receptors via somatic mutation (GO:0002566)3.28282621
70somatic hypermutation of immunoglobulin genes (GO:0016446)3.28282621
71maturation of 5.8S rRNA (GO:0000460)3.26401618
72telomere maintenance via recombination (GO:0000722)3.25988813
73IMP biosynthetic process (GO:0006188)3.25059302
74tryptophan metabolic process (GO:0006568)3.25050751
75glycine metabolic process (GO:0006544)3.21937075
76rRNA modification (GO:0000154)3.21483249
77pseudouridine synthesis (GO:0001522)3.19994990
78methionine biosynthetic process (GO:0009086)3.19060961
79regulation of helicase activity (GO:0051095)3.17918631
80amino acid salvage (GO:0043102)3.15260949
81L-methionine salvage (GO:0071267)3.15260949
82L-methionine biosynthetic process (GO:0071265)3.15260949
83mitotic recombination (GO:0006312)3.13717818
84nucleotide-excision repair, DNA gap filling (GO:0006297)3.12221759
85telomere maintenance via telomere lengthening (GO:0010833)3.11887987
86proteasome assembly (GO:0043248)3.11410842
87nuclear-transcribed mRNA catabolic process (GO:0000956)3.11214675
88pteridine-containing compound biosynthetic process (GO:0042559)3.10608253
89DNA damage response, detection of DNA damage (GO:0042769)3.10233307
90cullin deneddylation (GO:0010388)3.02904288
91negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.02576619
92reciprocal meiotic recombination (GO:0007131)3.01578840
93reciprocal DNA recombination (GO:0035825)3.01578840
94aromatic amino acid family catabolic process (GO:0009074)3.00402212
95chromatin remodeling at centromere (GO:0031055)2.99151016
96mitochondrial RNA metabolic process (GO:0000959)2.97076007
97recombinational repair (GO:0000725)2.96885119
98intra-S DNA damage checkpoint (GO:0031573)2.96705553
99transcription-coupled nucleotide-excision repair (GO:0006283)2.96647722
100ketone body metabolic process (GO:1902224)2.96479563
101double-strand break repair via homologous recombination (GO:0000724)2.95911598
102DNA deamination (GO:0045006)2.93075426
103transcription elongation from RNA polymerase III promoter (GO:0006385)2.90551035
104termination of RNA polymerase III transcription (GO:0006386)2.90551035
105nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.89917577
106detection of light stimulus involved in visual perception (GO:0050908)2.89753856
107detection of light stimulus involved in sensory perception (GO:0050962)2.89753856
108mRNA catabolic process (GO:0006402)2.89226454
109peptidyl-arginine N-methylation (GO:0035246)2.88913360
110peptidyl-arginine methylation (GO:0018216)2.88913360
111mannosylation (GO:0097502)2.88024235
112negative regulation of mRNA processing (GO:0050686)2.87252754
113termination of RNA polymerase II transcription (GO:0006369)2.86321318
114RNA catabolic process (GO:0006401)2.85351054
115RNA splicing, via transesterification reactions (GO:0000375)2.84113504
116oxidative phosphorylation (GO:0006119)2.83932307
117regulation of gene silencing by RNA (GO:0060966)2.83150744
118regulation of posttranscriptional gene silencing (GO:0060147)2.83150744
119regulation of gene silencing by miRNA (GO:0060964)2.83150744
120tRNA processing (GO:0008033)2.82654260
121mRNA splicing, via spliceosome (GO:0000398)2.82352389
122RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.82352389
123mitotic sister chromatid segregation (GO:0000070)2.81058287
124transcription from mitochondrial promoter (GO:0006390)2.80167902
125aromatic amino acid family metabolic process (GO:0009072)2.79776337
126CENP-A containing nucleosome assembly (GO:0034080)2.79676549
127protein deneddylation (GO:0000338)2.79608755
128protein localization to kinetochore (GO:0034501)2.79603585
129pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.79564534
130tRNA methylation (GO:0030488)2.79446887
131negative regulation of gene silencing (GO:0060969)2.79140993
132negative regulation of RNA splicing (GO:0033119)2.76353945
133ubiquinone biosynthetic process (GO:0006744)2.74489130
134tRNA aminoacylation for protein translation (GO:0006418)2.73156097
135ncRNA metabolic process (GO:0034660)2.72837982
136exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.72830371
137detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.72202645
138behavioral response to nicotine (GO:0035095)2.72183487
139inner mitochondrial membrane organization (GO:0007007)2.72063783
140ncRNA processing (GO:0034470)2.71924256
141histone H2A acetylation (GO:0043968)2.70608376
142maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.70125917
143regulation of histone H3-K9 methylation (GO:0051570)2.69754782
144spliceosomal tri-snRNP complex assembly (GO:0000244)2.68621241
145IMP metabolic process (GO:0046040)2.68612288
146sulfur amino acid biosynthetic process (GO:0000097)2.68553706
147aspartate family amino acid biosynthetic process (GO:0009067)2.68473953
148establishment of viral latency (GO:0019043)2.66767071
149methionine metabolic process (GO:0006555)2.66352465
150pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.66127040
151regulation of nuclear cell cycle DNA replication (GO:0033262)2.65235750
152regulation of centriole replication (GO:0046599)2.63112510
153photoreceptor cell maintenance (GO:0045494)2.62445030
154regulation of hippo signaling (GO:0035330)2.59533972
155tRNA metabolic process (GO:0006399)2.59496495
156tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.59424213
157RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.59424213
158negative regulation of cytosolic calcium ion concentration (GO:0051481)2.59287603
159RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.57843673
160protein-cofactor linkage (GO:0018065)2.57015744
161amine catabolic process (GO:0009310)2.56316164
162cellular biogenic amine catabolic process (GO:0042402)2.56316164
163regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.55845568
164regulation of mitotic spindle checkpoint (GO:1903504)2.55845568
165tachykinin receptor signaling pathway (GO:0007217)2.55789361
166indole-containing compound metabolic process (GO:0042430)2.55745272
167protein K6-linked ubiquitination (GO:0085020)2.55434511
168ubiquinone metabolic process (GO:0006743)2.54073423
169ribonucleoprotein complex disassembly (GO:0032988)2.54046649
170transcription elongation from RNA polymerase I promoter (GO:0006362)2.52342960
171chaperone-mediated protein transport (GO:0072321)2.50913514
172base-excision repair, AP site formation (GO:0006285)2.50781474
173preassembly of GPI anchor in ER membrane (GO:0016254)2.49696938
174DNA double-strand break processing (GO:0000729)2.49340654
175NAD biosynthetic process (GO:0009435)2.47922451
176aspartate family amino acid catabolic process (GO:0009068)2.46311627
177DNA catabolic process, exonucleolytic (GO:0000738)2.45427865
178rRNA methylation (GO:0031167)2.45214166
179tRNA modification (GO:0006400)2.43199004

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.26699787
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.74149771
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.73511666
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.51201196
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.45022102
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.44454499
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.36840510
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.19703661
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.11341126
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.09754818
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.06650421
12ETS1_20019798_ChIP-Seq_JURKAT_Human3.05749706
13VDR_22108803_ChIP-Seq_LS180_Human2.96782629
14ZNF274_21170338_ChIP-Seq_K562_Hela2.95095759
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.86932450
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.70537554
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.65780834
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.63156015
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.58848097
20* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.51649247
21XRN2_22483619_ChIP-Seq_HELA_Human2.41781928
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.39566512
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.23749023
24POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.21869898
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.20366772
26KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.18166080
27KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.18166080
28KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.18166080
29E2F1_18555785_ChIP-Seq_MESCs_Mouse2.17040488
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.15181277
31NANOG_18555785_ChIP-Seq_MESCs_Mouse2.12085751
32GBX2_23144817_ChIP-Seq_PC3_Human2.11616002
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.08463422
34ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.05088726
35FOXP3_21729870_ChIP-Seq_TREG_Human2.00544026
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.98314771
37POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.97877945
38* DCP1A_22483619_ChIP-Seq_HELA_Human1.97502584
39YY1_21170310_ChIP-Seq_MESCs_Mouse1.97328051
40IGF1R_20145208_ChIP-Seq_DFB_Human1.96498777
41VDR_23849224_ChIP-Seq_CD4+_Human1.96493742
42POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.95202660
43MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.93238831
44SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.93040205
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.90861579
46SOX2_18555785_ChIP-Seq_MESCs_Mouse1.89564965
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.87853082
48PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.85746070
49TTF2_22483619_ChIP-Seq_HELA_Human1.84988499
50SALL1_21062744_ChIP-ChIP_HESCs_Human1.83009145
51EWS_26573619_Chip-Seq_HEK293_Human1.81671201
52GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81401976
53* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.80812818
54GABP_19822575_ChIP-Seq_HepG2_Human1.79824914
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.73001108
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.72543848
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66599675
58RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66271267
59KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.65064281
60FUS_26573619_Chip-Seq_HEK293_Human1.64232624
61NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.62237479
62E2F1_21310950_ChIP-Seq_MCF-7_Human1.59118026
63POU3F2_20337985_ChIP-ChIP_501MEL_Human1.57278327
64ELF1_17652178_ChIP-ChIP_JURKAT_Human1.56415742
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53718333
66TCF3_18692474_ChIP-Seq_MEFs_Mouse1.51708075
67ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48309945
68ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48039123
69TP53_22573176_ChIP-Seq_HFKS_Human1.47645060
70TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.45637191
71STAT3_1855785_ChIP-Seq_MESCs_Mouse1.43116579
72KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.42428878
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41851712
74SRF_21415370_ChIP-Seq_HL-1_Mouse1.41469240
75AR_21909140_ChIP-Seq_LNCAP_Human1.40882955
76MYC_18940864_ChIP-ChIP_HL60_Human1.39719233
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.39357412
78PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.39297971
79ESR1_15608294_ChIP-ChIP_MCF-7_Human1.39017870
80EGR1_23403033_ChIP-Seq_LIVER_Mouse1.37968299
81CIITA_25753668_ChIP-Seq_RAJI_Human1.36803171
82CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35890508
83TAF15_26573619_Chip-Seq_HEK293_Human1.34335989
84PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33234372
85HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32727189
86ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.31484992
87ER_23166858_ChIP-Seq_MCF-7_Human1.29244337
88TCF3_18692474_ChIP-Seq_MESCs_Mouse1.25997119
89EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25380273
90ELK1_19687146_ChIP-ChIP_HELA_Human1.24345487
91SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.22411896
92NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.20609456
93NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.18027856
94SOX2_18692474_ChIP-Seq_MEFs_Mouse1.16087379
95TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.16025172
96P300_19829295_ChIP-Seq_ESCs_Human1.15579223
97* KDM5A_27292631_Chip-Seq_BREAST_Human1.14346137
98* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.14257140
99CBP_20019798_ChIP-Seq_JUKART_Human1.14061964
100IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14061964
101OCT4_18692474_ChIP-Seq_MEFs_Mouse1.12504911
102NANOG_19829295_ChIP-Seq_ESCs_Human1.10717582
103SOX2_19829295_ChIP-Seq_ESCs_Human1.10717582
104BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10406970
105CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.10059707
106ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.09950266
107SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07443121
108KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07280279
109SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06185945
110NFE2_27457419_Chip-Seq_LIVER_Mouse1.06046300
111STAT3_23295773_ChIP-Seq_U87_Human1.05707174
112KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04642513
113POU5F1_16518401_ChIP-PET_MESCs_Mouse1.04068657
114UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03908795
115PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03352793
116TCF4_23295773_ChIP-Seq_U87_Human1.02815805
117TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02017979
118POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02017979
119KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01737839
120SOX2_16153702_ChIP-ChIP_HESCs_Human1.01524922
121CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.00725899
122AR_20517297_ChIP-Seq_VCAP_Human1.00126600
123SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98874080
124MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98065430
125CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97627114
126RBPJ_22232070_ChIP-Seq_NCS_Mouse0.97259161
127CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96866463
128NCOR_22424771_ChIP-Seq_293T_Human0.96089191
129DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96054729
130PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95978361
131TP63_19390658_ChIP-ChIP_HaCaT_Human0.95924924
132POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.95813081
133* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95423775
134EZH2_27294783_Chip-Seq_NPCs_Mouse0.94510118
135FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.93973977
136HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92433340
137SOX2_18692474_ChIP-Seq_MESCs_Mouse0.91986150
138FOXA1_27270436_Chip-Seq_PROSTATE_Human0.91821366
139FOXA1_25329375_ChIP-Seq_VCAP_Human0.91821366
140NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.91136787
141AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90709472
142POU5F1_16153702_ChIP-ChIP_HESCs_Human0.90516639
143IRF1_19129219_ChIP-ChIP_H3396_Human0.89168739
144EZH2_22144423_ChIP-Seq_EOC_Human0.88856514
145HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.88312780
146NANOG_18692474_ChIP-Seq_MEFs_Mouse0.87592758
147NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.86428543
148TCF4_22108803_ChIP-Seq_LS180_Human0.86181799
149BCAT_22108803_ChIP-Seq_LS180_Human0.85651597
150GATA3_21878914_ChIP-Seq_MCF-7_Human0.84985196
151SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.84186259

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.17642046
2MP0009379_abnormal_foot_pigmentation3.66972369
3MP0008057_abnormal_DNA_replication3.66432612
4MP0004957_abnormal_blastocyst_morpholog3.59454877
5MP0010094_abnormal_chromosome_stability3.59341525
6MP0006292_abnormal_olfactory_placode3.39493908
7MP0003111_abnormal_nucleus_morphology3.14864822
8MP0003693_abnormal_embryo_hatching3.03798921
9MP0003077_abnormal_cell_cycle2.97434869
10MP0003646_muscle_fatigue2.93110234
11MP0008058_abnormal_DNA_repair2.76332182
12MP0008932_abnormal_embryonic_tissue2.49200891
13MP0003123_paternal_imprinting2.48469848
14MP0003195_calcinosis2.39963471
15MP0005551_abnormal_eye_electrophysiolog2.16513357
16MP0003136_yellow_coat_color2.08936988
17MP0000372_irregular_coat_pigmentation2.06716595
18MP0003950_abnormal_plasma_membrane2.06178693
19MP0004133_heterotaxia2.03012032
20MP0005360_urolithiasis2.00462868
21MP0003890_abnormal_embryonic-extraembry1.94655515
22MP0010030_abnormal_orbit_morphology1.91403363
23MP0000569_abnormal_digit_pigmentation1.88437684
24MP0004147_increased_porphyrin_level1.84450771
25MP0009046_muscle_twitch1.80459973
26MP0005670_abnormal_white_adipose1.77746606
27MP0001730_embryonic_growth_arrest1.77694016
28MP0003119_abnormal_digestive_system1.74947984
29MP0005646_abnormal_pituitary_gland1.74108194
30MP0001968_abnormal_touch/_nociception1.72638170
31MP0002736_abnormal_nociception_after1.72222857
32MP0005085_abnormal_gallbladder_physiolo1.70576083
33MP0003941_abnormal_skin_development1.67357749
34MP0003786_premature_aging1.66245952
35MP0006035_abnormal_mitochondrial_morpho1.65238704
36MP0002139_abnormal_hepatobiliary_system1.62185734
37MP0005645_abnormal_hypothalamus_physiol1.61171517
38MP0005253_abnormal_eye_physiology1.59801728
39MP0008007_abnormal_cellular_replicative1.57277947
40MP0003718_maternal_effect1.54921007
41MP0000350_abnormal_cell_proliferation1.54901008
42MP0003121_genomic_imprinting1.50300858
43MP0000566_synostosis1.47226606
44MP0006036_abnormal_mitochondrial_physio1.44068613
45MP0006276_abnormal_autonomic_nervous1.41894904
46MP0001293_anophthalmia1.40224104
47MP0005266_abnormal_metabolism1.39589262
48MP0002085_abnormal_embryonic_tissue1.38304050
49MP0005248_abnormal_Harderian_gland1.37380663
50MP0008877_abnormal_DNA_methylation1.34726133
51MP0004197_abnormal_fetal_growth/weight/1.31814825
52MP0001697_abnormal_embryo_size1.31511922
53MP0002084_abnormal_developmental_patter1.31346779
54MP0002653_abnormal_ependyma_morphology1.30442878
55MP0005380_embryogenesis_phenotype1.28724425
56MP0001672_abnormal_embryogenesis/_devel1.28724425
57MP0002163_abnormal_gland_morphology1.26465472
58MP0001529_abnormal_vocalization1.26421595
59MP0002095_abnormal_skin_pigmentation1.25524951
60MP0008995_early_reproductive_senescence1.25262759
61MP0008789_abnormal_olfactory_epithelium1.24238259
62MP0002160_abnormal_reproductive_system1.24007401
63MP0002876_abnormal_thyroid_physiology1.22284705
64MP0002938_white_spotting1.21941553
65MP0002638_abnormal_pupillary_reflex1.21638411
66MP0005410_abnormal_fertilization1.19718143
67MP0008872_abnormal_physiological_respon1.19707068
68MP0002080_prenatal_lethality1.19672286
69MP0003315_abnormal_perineum_morphology1.19397721
70MP0004142_abnormal_muscle_tone1.17188031
71MP0001188_hyperpigmentation1.14115377
72MP0004145_abnormal_muscle_electrophysio1.12664834
73MP0005394_taste/olfaction_phenotype1.12070900
74MP0005499_abnormal_olfactory_system1.12070900
75MP0002751_abnormal_autonomic_nervous1.10921851
76MP0002210_abnormal_sex_determination1.10435508
77MP0006072_abnormal_retinal_apoptosis1.06947403
78MP0004043_abnormal_pH_regulation1.06068332
79MP0009672_abnormal_birth_weight1.05638022
80MP0001501_abnormal_sleep_pattern1.05259996
81MP0003698_abnormal_male_reproductive1.05052674
82MP0002396_abnormal_hematopoietic_system1.03956700
83MP0001145_abnormal_male_reproductive1.02868418
84MP0003984_embryonic_growth_retardation1.01908960
85MP0009745_abnormal_behavioral_response1.01711743
86MP0000631_abnormal_neuroendocrine_gland1.01272823
87MP0002088_abnormal_embryonic_growth/wei1.01154833
88MP0003186_abnormal_redox_activity1.00862390
89MP0002735_abnormal_chemical_nociception1.00532655
90MP0003137_abnormal_impulse_conducting1.00245448
91MP0010352_gastrointestinal_tract_polyps0.99693265
92MP0003567_abnormal_fetal_cardiomyocyte0.99175308
93MP0005365_abnormal_bile_salt0.98019995
94MP0003937_abnormal_limbs/digits/tail_de0.97693026
95MP0002229_neurodegeneration0.95877474
96MP0002102_abnormal_ear_morphology0.95226241
97MP0003880_abnormal_central_pattern0.95128783
98MP0005408_hypopigmentation0.94445008
99MP0002086_abnormal_extraembryonic_tissu0.94203963
100MP0002272_abnormal_nervous_system0.93821523
101MP0000427_abnormal_hair_cycle0.93500460
102MP0003861_abnormal_nervous_system0.92524277
103MP0000462_abnormal_digestive_system0.92092985
104MP0002138_abnormal_hepatobiliary_system0.91502009
105MP0003787_abnormal_imprinting0.90535196
106MP0001286_abnormal_eye_development0.89418029
107MP0000313_abnormal_cell_death0.89266528
108MP0001485_abnormal_pinna_reflex0.88567698
109MP0008875_abnormal_xenobiotic_pharmacok0.87295938
110MP0002111_abnormal_tail_morphology0.86840708
111MP0001984_abnormal_olfaction0.86599626
112MP0004215_abnormal_myocardial_fiber0.85877609
113MP0000653_abnormal_sex_gland0.85021693
114MP0001486_abnormal_startle_reflex0.84857712
115MP0002249_abnormal_larynx_morphology0.83628765
116MP0009697_abnormal_copulation0.83095127
117MP0000049_abnormal_middle_ear0.82461850
118MP0010386_abnormal_urinary_bladder0.82093879
119MP0003252_abnormal_bile_duct0.81791525
120MP0005389_reproductive_system_phenotype0.81337116
121MP0008775_abnormal_heart_ventricle0.80095988
122MP0000647_abnormal_sebaceous_gland0.79173194
123MP0005395_other_phenotype0.77491507
124MP0001929_abnormal_gametogenesis0.77280573
125MP0003938_abnormal_ear_development0.77137585
126MP0005379_endocrine/exocrine_gland_phen0.76726918
127MP0001764_abnormal_homeostasis0.76306638
128MP0002557_abnormal_social/conspecific_i0.75897127
129MP0002067_abnormal_sensory_capabilities0.75717480
130MP0004742_abnormal_vestibular_system0.75279673
131MP0009053_abnormal_anal_canal0.75140536
132MP0001324_abnormal_eye_pigmentation0.74943159
133MP0005174_abnormal_tail_pigmentation0.74800201
134MP0005636_abnormal_mineral_homeostasis0.74202254
135MP0005330_cardiomyopathy0.73715053
136MP0005171_absent_coat_pigmentation0.73563870
137MP0003011_delayed_dark_adaptation0.73106003
138MP0000358_abnormal_cell_content/0.73105356
139MP0005386_behavior/neurological_phenoty0.73099895
140MP0004924_abnormal_behavior0.73099895
141MP0002132_abnormal_respiratory_system0.72574574
142MP0005195_abnormal_posterior_eye0.72054953
143MP0000490_abnormal_crypts_of0.70083756
144MP0002837_dystrophic_cardiac_calcinosis0.67409598
145MP0001919_abnormal_reproductive_system0.67310103
146MP0002019_abnormal_tumor_incidence0.66760745
147MP0002277_abnormal_respiratory_mucosa0.66082245
148MP0005332_abnormal_amino_acid0.65854038
149MP0005075_abnormal_melanosome_morpholog0.64220520
150MP0005376_homeostasis/metabolism_phenot0.63734829
151MP0002127_abnormal_cardiovascular_syste0.63414412

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.56544976
2Abnormality of cells of the erythroid lineage (HP:0012130)3.59549622
3Colon cancer (HP:0003003)3.55574805
4Medulloblastoma (HP:0002885)3.55186959
5Pancreatic cysts (HP:0001737)3.46277062
6Acute necrotizing encephalopathy (HP:0006965)3.43590908
7Abnormality of the labia minora (HP:0012880)3.38448256
8Macrocytic anemia (HP:0001972)3.29728416
9Abnormal number of erythroid precursors (HP:0012131)3.21677759
10Increased hepatocellular lipid droplets (HP:0006565)3.18227736
11Abnormal mitochondria in muscle tissue (HP:0008316)3.13744888
12Abnormality of glycolysis (HP:0004366)3.11997824
13Increased serum pyruvate (HP:0003542)3.11997824
14Mitochondrial inheritance (HP:0001427)3.09513304
15Acute encephalopathy (HP:0006846)3.09373913
16Breast hypoplasia (HP:0003187)3.04536948
17Pancreatic fibrosis (HP:0100732)3.02007853
18Increased CSF lactate (HP:0002490)3.01267237
19Hepatocellular necrosis (HP:0001404)2.97485364
20Ependymoma (HP:0002888)2.93659346
21Lipid accumulation in hepatocytes (HP:0006561)2.93157171
22Cerebral edema (HP:0002181)2.89983500
23Oral leukoplakia (HP:0002745)2.87496609
24Abnormality of pyrimidine metabolism (HP:0004353)2.86390023
25Abnormality of alanine metabolism (HP:0010916)2.86052421
26Hyperalaninemia (HP:0003348)2.86052421
27Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.86052421
28Molar tooth sign on MRI (HP:0002419)2.84351276
29Abnormality of midbrain morphology (HP:0002418)2.84351276
30Abnormality of the renal cortex (HP:0011035)2.82788123
31Chromosomal breakage induced by crosslinking agents (HP:0003221)2.81229860
32Chromsome breakage (HP:0040012)2.78378306
33Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.77620299
34Increased serum lactate (HP:0002151)2.77321163
35Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.75552484
36Decreased activity of mitochondrial respiratory chain (HP:0008972)2.75552484
37Hepatic necrosis (HP:0002605)2.71350255
38True hermaphroditism (HP:0010459)2.70308652
39Gaze-evoked nystagmus (HP:0000640)2.67612263
40Renal cortical cysts (HP:0000803)2.64381758
41Rhabdomyosarcoma (HP:0002859)2.63268976
42Supernumerary spleens (HP:0009799)2.61723565
43Progressive macrocephaly (HP:0004481)2.59957497
44Abnormal number of incisors (HP:0011064)2.59200387
45Pallor (HP:0000980)2.57029967
46Birth length less than 3rd percentile (HP:0003561)2.55633163
47Type I transferrin isoform profile (HP:0003642)2.55252318
48Congenital stationary night blindness (HP:0007642)2.54128289
49Aplastic anemia (HP:0001915)2.51816455
50Attenuation of retinal blood vessels (HP:0007843)2.50014897
51Rib fusion (HP:0000902)2.49366500
52Abnormality of the renal collecting system (HP:0004742)2.48224892
53Medial flaring of the eyebrow (HP:0010747)2.44630039
54Patellar aplasia (HP:0006443)2.44311135
55Ragged-red muscle fibers (HP:0003200)2.41463349
56Microvesicular hepatic steatosis (HP:0001414)2.40772666
57Thyroid-stimulating hormone excess (HP:0002925)2.39197685
58Nephronophthisis (HP:0000090)2.37695238
59Abnormality of the astrocytes (HP:0100707)2.35668746
60Astrocytoma (HP:0009592)2.35668746
61Large for gestational age (HP:0001520)2.35291816
62Absent radius (HP:0003974)2.32878980
63Aplasia/Hypoplasia of the patella (HP:0006498)2.32405613
64Progressive external ophthalmoplegia (HP:0000590)2.31930429
65Hypobetalipoproteinemia (HP:0003563)2.31499318
66Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.30836148
67Cerebral hypomyelination (HP:0006808)2.30458561
68Aplasia/Hypoplasia of the sacrum (HP:0008517)2.29601272
69Absent thumb (HP:0009777)2.23757928
70Aplasia involving forearm bones (HP:0009822)2.21168215
71Absent forearm bone (HP:0003953)2.21168215
72Bony spicule pigmentary retinopathy (HP:0007737)2.20661547
73Lactic acidosis (HP:0003128)2.18658595
74Intestinal atresia (HP:0011100)2.16577421
75Horseshoe kidney (HP:0000085)2.16003990
76Abnormality of the renal medulla (HP:0100957)2.15753380
77Neoplasm of the oral cavity (HP:0100649)2.14243040
78Increased intramyocellular lipid droplets (HP:0012240)2.12377316
79Renal Fanconi syndrome (HP:0001994)2.11484215
80Hyperglycinuria (HP:0003108)2.11453798
81Abnormality of the ileum (HP:0001549)2.11425864
82Exercise intolerance (HP:0003546)2.10685675
83Type II lissencephaly (HP:0007260)2.09572741
84Meckel diverticulum (HP:0002245)2.09148024
85Cerebellar dysplasia (HP:0007033)2.08975439
86Methylmalonic aciduria (HP:0012120)2.08436709
87Glioma (HP:0009733)2.08004059
88Neoplasm of striated muscle (HP:0009728)2.05721098
89Angiofibromas (HP:0010615)2.04429766
90Adenoma sebaceum (HP:0009720)2.04429766
91Abnormality of the preputium (HP:0100587)2.03830625
92Cystic liver disease (HP:0006706)2.03172174
93Generalized aminoaciduria (HP:0002909)2.01182617
94Abolished electroretinogram (ERG) (HP:0000550)1.99554914
95Abnormality of reticulocytes (HP:0004312)1.99476765
96Congenital primary aphakia (HP:0007707)1.98195793
97Volvulus (HP:0002580)1.96713206
98Leukodystrophy (HP:0002415)1.96347002
99Duplicated collecting system (HP:0000081)1.95939040
100Abnormality of DNA repair (HP:0003254)1.95932278
101Abnormal glycosylation (HP:0012345)1.95432909
102Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.95432909
103Abnormal protein N-linked glycosylation (HP:0012347)1.95432909
104Abnormal protein glycosylation (HP:0012346)1.95432909
105Aplasia/Hypoplasia of the tibia (HP:0005772)1.95127679
106Abnormality of monocarboxylic acid metabolism (HP:0010996)1.94444638
107Sclerocornea (HP:0000647)1.93606646
1083-Methylglutaconic aciduria (HP:0003535)1.93207277
109Lethargy (HP:0001254)1.91959189
110High anterior hairline (HP:0009890)1.91294435
111Impulsivity (HP:0100710)1.90855215
112Emotional lability (HP:0000712)1.90810277
113Triphalangeal thumb (HP:0001199)1.89949877
114Constricted visual fields (HP:0001133)1.89468278
115Respiratory failure (HP:0002878)1.89397838
116Hyperglycinemia (HP:0002154)1.88902305
117Central scotoma (HP:0000603)1.87994899
118Gait imbalance (HP:0002141)1.87092511
119Progressive cerebellar ataxia (HP:0002073)1.86375368
120Abnormality of the pons (HP:0007361)1.85836771
121Rectal fistula (HP:0100590)1.83779893
122Rectovaginal fistula (HP:0000143)1.83779893
123Progressive muscle weakness (HP:0003323)1.82545177
124Agnosia (HP:0010524)1.82311316
125Sloping forehead (HP:0000340)1.81536117
126Hyperventilation (HP:0002883)1.81438897
127Hypochromic microcytic anemia (HP:0004840)1.81423200
128Abnormality of serum amino acid levels (HP:0003112)1.81143892
129Increased muscle lipid content (HP:0009058)1.80743495
130Atresia of the external auditory canal (HP:0000413)1.79607916
131Asplenia (HP:0001746)1.79053099
132Ketoacidosis (HP:0001993)1.79012713
133Pendular nystagmus (HP:0012043)1.78990115
134Nephrogenic diabetes insipidus (HP:0009806)1.78886623
135Abnormality of cochlea (HP:0000375)1.78509040
136Abnormality of chromosome stability (HP:0003220)1.78432466
137CNS demyelination (HP:0007305)1.77442455
138Abnormality of serine family amino acid metabolism (HP:0010894)1.77084190
139Abnormality of glycine metabolism (HP:0010895)1.77084190
140Supernumerary bones of the axial skeleton (HP:0009144)1.76750919
141Tubular atrophy (HP:0000092)1.75216182
142Ileus (HP:0002595)1.74759737
143Clubbing of toes (HP:0100760)1.74650644
144Basal cell carcinoma (HP:0002671)1.74154506
145Delayed CNS myelination (HP:0002188)1.74137332
146Selective tooth agenesis (HP:0001592)1.73529784
147Intrahepatic cholestasis (HP:0001406)1.72965947
148Concave nail (HP:0001598)1.72585390
149Astigmatism (HP:0000483)1.72533679
150Missing ribs (HP:0000921)1.72364265
151Aplasia/Hypoplasia of the uvula (HP:0010293)1.71432863
152Neoplasm of the pancreas (HP:0002894)1.71201934
153Optic disc pallor (HP:0000543)1.70029725
154Rough bone trabeculation (HP:0100670)1.68472475

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.33554523
2CDK195.11489619
3TLK14.53729356
4SRPK13.63675072
5WEE13.25779076
6BUB13.21471036
7CDC73.02105769
8STK163.00225835
9BMPR1B2.65525751
10NEK12.56923754
11EIF2AK12.51874566
12TAOK32.48930775
13PNCK2.33120088
14VRK22.21005889
15NUAK12.07062697
16MKNK22.00921212
17MKNK12.00082578
18MAP3K101.99999908
19TSSK61.99072480
20TTK1.97085674
21EPHA21.95996175
22DYRK31.95285895
23MAP4K21.91535012
24PDK21.80266740
25VRK11.74768988
26CDK71.70266001
27WNK41.69549807
28BCKDK1.63246974
29GRK11.58554436
30PINK11.58082536
31INSRR1.55510104
32NME21.54990122
33CDK121.54185333
34PLK11.45829538
35BRSK21.44158635
36ACVR1B1.42026863
37RPS6KB21.36856219
38CHEK21.32146230
39AURKA1.32142380
40TESK21.26623484
41NME11.25190443
42CDK41.23324298
43MAP3K41.17894797
44ATR1.16836217
45PLK31.14762127
46PLK41.13249985
47BRAF1.12440370
48AURKB1.09329186
49NEK21.04765786
50MST41.02762227
51CASK1.01076627
52EIF2AK30.98918268
53CHEK10.98611056
54STK390.96116348
55CSNK2A20.93353788
56ADRBK20.88973166
57BRD40.87034680
58PIK3CG0.85693653
59DYRK20.85330409
60CSNK1G30.84107078
61OBSCN0.83008288
62TNIK0.81226852
63PRKCI0.80855535
64ADRBK10.78769953
65CDK20.78109847
66PASK0.77658865
67CSNK2A10.76744895
68AKT30.75818835
69PHKG20.75815684
70PHKG10.75815684
71PIM20.75743144
72CSNK1E0.75432061
73ATM0.73943465
74UHMK10.73316662
75NTRK30.71924326
76MAPKAPK30.71503311
77TGFBR10.71240116
78MUSK0.71148568
79TRIM280.70899633
80OXSR10.68843674
81MAP3K80.67278604
82ICK0.65477735
83STK40.63932544
84FLT30.61614578
85CDK10.61117712
86MAP3K110.61036466
87STK38L0.61004336
88MAP2K20.59920633
89CDK11A0.59356433
90DAPK10.58622257
91PAK40.58515775
92PAK30.57929696
93PBK0.56700454
94PAK10.56194805
95ZAK0.56155250
96MARK10.55447386
97MAPKAPK50.53661166
98PRKCE0.53308034
99SIK20.53201744
100CSNK1G10.53103266
101DAPK30.52952725
102PRKAA10.52442212
103MAP2K60.51400683
104PLK20.50494509
105EPHA30.50294253
106LATS10.50170114
107ALK0.49960495
108TXK0.49038128
109PRKAA20.46914686
110BRSK10.46009095
111KDR0.45815943
112PRKACB0.45718692
113CSNK1D0.45018428
114STK30.44295186
115PRKDC0.44245976
116MAPK110.44115458
117YES10.43547192
118RPS6KA50.43289218
119CSNK1A1L0.42362820
120WNK30.41746075
121AKT20.41525744
122CSNK1A10.40198461
123ARAF0.39698843
124CDK80.39600470
125CDK30.38717797
126FGFR20.37930068
127MAP2K10.37689446
128EPHA40.37347152
129ERBB40.36665390
130PRKCG0.36415582
131LIMK10.35810262
132GRK60.33394517
133CSNK1G20.31098733
134CDK150.30951611
135CDK140.29073058
136CDK180.28802015
137CCNB10.27026423
138EIF2AK20.26861631
139FES0.26856898
140GSK3B0.26251440
141SCYL20.25969684
142MAPK130.25503527
143EPHB20.25199773
144ILK0.25157619
145MAPK40.25081584
146PDK40.24347892
147PDK30.24347892
148LMTK20.24153725

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030104.29455418
2DNA replication_Homo sapiens_hsa030303.68629258
3Mismatch repair_Homo sapiens_hsa034303.61531965
4Spliceosome_Homo sapiens_hsa030403.05322367
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.03127853
6RNA polymerase_Homo sapiens_hsa030202.62820321
7Proteasome_Homo sapiens_hsa030502.56334707
8One carbon pool by folate_Homo sapiens_hsa006702.51508993
9Homologous recombination_Homo sapiens_hsa034402.44950531
10RNA transport_Homo sapiens_hsa030132.34864443
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.29411547
12Oxidative phosphorylation_Homo sapiens_hsa001902.26559211
13Base excision repair_Homo sapiens_hsa034102.13144806
14Parkinsons disease_Homo sapiens_hsa050122.10695622
15Nucleotide excision repair_Homo sapiens_hsa034202.08366504
16Pyrimidine metabolism_Homo sapiens_hsa002402.06266166
17Selenocompound metabolism_Homo sapiens_hsa004501.93928000
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.82777182
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.73048140
20Huntingtons disease_Homo sapiens_hsa050161.68979915
21Fanconi anemia pathway_Homo sapiens_hsa034601.57515145
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.55265790
23Sulfur relay system_Homo sapiens_hsa041221.52405598
24Phototransduction_Homo sapiens_hsa047441.46538050
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.45705882
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.44289290
27Biosynthesis of amino acids_Homo sapiens_hsa012301.44288894
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.37284565
29Cell cycle_Homo sapiens_hsa041101.34962014
30mRNA surveillance pathway_Homo sapiens_hsa030151.33783695
31Basal transcription factors_Homo sapiens_hsa030221.32360038
32Non-homologous end-joining_Homo sapiens_hsa034501.31962822
33RNA degradation_Homo sapiens_hsa030181.31356552
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.25402181
35Pyruvate metabolism_Homo sapiens_hsa006201.24988507
36Carbon metabolism_Homo sapiens_hsa012001.24253897
37Alzheimers disease_Homo sapiens_hsa050101.23786571
38Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.19782070
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.19116861
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18638222
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.15353340
42ABC transporters_Homo sapiens_hsa020101.10222185
43Nitrogen metabolism_Homo sapiens_hsa009101.08865590
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.05833512
45Systemic lupus erythematosus_Homo sapiens_hsa053221.05494653
46Propanoate metabolism_Homo sapiens_hsa006401.05361375
47Purine metabolism_Homo sapiens_hsa002301.04111837
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.03484077
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.96437966
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95534377
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.93942695
52Primary bile acid biosynthesis_Homo sapiens_hsa001200.93774297
53Fatty acid degradation_Homo sapiens_hsa000710.92927275
54Folate biosynthesis_Homo sapiens_hsa007900.92297646
55Fatty acid elongation_Homo sapiens_hsa000620.89295378
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87541266
57Cardiac muscle contraction_Homo sapiens_hsa042600.86757597
58Arginine and proline metabolism_Homo sapiens_hsa003300.84962197
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83913901
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82292450
61beta-Alanine metabolism_Homo sapiens_hsa004100.82206013
62Butanoate metabolism_Homo sapiens_hsa006500.82187362
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79828571
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78551540
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.78374908
66Glutathione metabolism_Homo sapiens_hsa004800.78242874
67Tryptophan metabolism_Homo sapiens_hsa003800.76571592
68Nicotine addiction_Homo sapiens_hsa050330.74826148
69Arginine biosynthesis_Homo sapiens_hsa002200.74063149
70Tyrosine metabolism_Homo sapiens_hsa003500.72502541
71Olfactory transduction_Homo sapiens_hsa047400.72258723
72Peroxisome_Homo sapiens_hsa041460.70988789
73Sulfur metabolism_Homo sapiens_hsa009200.69730913
74Metabolic pathways_Homo sapiens_hsa011000.68585800
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66243314
76Glycerolipid metabolism_Homo sapiens_hsa005610.65935157
77Phenylalanine metabolism_Homo sapiens_hsa003600.61310385
78Fatty acid metabolism_Homo sapiens_hsa012120.60221304
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58994822
80Pentose phosphate pathway_Homo sapiens_hsa000300.57469155
81Caffeine metabolism_Homo sapiens_hsa002320.56862786
82Taste transduction_Homo sapiens_hsa047420.56493335
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55459263
84Retinol metabolism_Homo sapiens_hsa008300.54222125
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53126879
86Ether lipid metabolism_Homo sapiens_hsa005650.50741742
87Chemical carcinogenesis_Homo sapiens_hsa052040.50462667
88Lysine degradation_Homo sapiens_hsa003100.48664249
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47415579
90Protein export_Homo sapiens_hsa030600.46928291
91Fatty acid biosynthesis_Homo sapiens_hsa000610.46565147
92Oocyte meiosis_Homo sapiens_hsa041140.45715718
93Basal cell carcinoma_Homo sapiens_hsa052170.45240664
94Linoleic acid metabolism_Homo sapiens_hsa005910.44269039
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.42989456
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.42556056
97N-Glycan biosynthesis_Homo sapiens_hsa005100.40494416
98Histidine metabolism_Homo sapiens_hsa003400.40052170
99Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37913374
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37801305
101Alcoholism_Homo sapiens_hsa050340.37097330
102Fructose and mannose metabolism_Homo sapiens_hsa000510.36740613
103Regulation of autophagy_Homo sapiens_hsa041400.35841395
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35113241
105Fat digestion and absorption_Homo sapiens_hsa049750.34715270
106p53 signaling pathway_Homo sapiens_hsa041150.33788159
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32387964
108Galactose metabolism_Homo sapiens_hsa000520.32070810
109Arachidonic acid metabolism_Homo sapiens_hsa005900.31868677
110Steroid biosynthesis_Homo sapiens_hsa001000.28115066
111Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.26735001
112Vitamin B6 metabolism_Homo sapiens_hsa007500.26114197
113Epstein-Barr virus infection_Homo sapiens_hsa051690.25832969
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.22603694
115Renin-angiotensin system_Homo sapiens_hsa046140.22498268
116Maturity onset diabetes of the young_Homo sapiens_hsa049500.20788939
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.18731068

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