MRPS6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S6P family. Pseudogenes corresponding to this gene are found on chromosomes 1p and 12q. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ATP synthesis coupled proton transport (GO:0015986)6.78062346
2energy coupled proton transport, down electrochemical gradient (GO:0015985)6.78062346
3viral transcription (GO:0019083)6.76517397
4translational termination (GO:0006415)6.59060355
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.47396404
6ribosomal small subunit biogenesis (GO:0042274)6.17648341
7translational elongation (GO:0006414)5.81670250
8ribosomal small subunit assembly (GO:0000028)5.64995162
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.60216624
10cotranslational protein targeting to membrane (GO:0006613)5.54242388
11protein targeting to ER (GO:0045047)5.50872970
12cellular protein complex disassembly (GO:0043624)5.40607535
13protein localization to endoplasmic reticulum (GO:0070972)5.24983613
14establishment of protein localization to endoplasmic reticulum (GO:0072599)5.24068237
15translational initiation (GO:0006413)5.23856872
16viral life cycle (GO:0019058)5.23047298
17mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.15518852
18ribosomal large subunit biogenesis (GO:0042273)5.12961731
19respiratory electron transport chain (GO:0022904)4.98753923
20maturation of SSU-rRNA (GO:0030490)4.93202889
21nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.90864896
22electron transport chain (GO:0022900)4.89923768
23proteasome assembly (GO:0043248)4.85366997
24DNA deamination (GO:0045006)4.62467305
25protein complex disassembly (GO:0043241)4.57468819
26* translation (GO:0006412)4.36506533
27macromolecular complex disassembly (GO:0032984)4.36226544
28NADH dehydrogenase complex assembly (GO:0010257)4.09248980
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.09248980
30mitochondrial respiratory chain complex I assembly (GO:0032981)4.09248980
31establishment of protein localization to mitochondrial membrane (GO:0090151)4.06580822
32negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.05637651
33chaperone-mediated protein transport (GO:0072321)3.97767412
34protein targeting to membrane (GO:0006612)3.96923503
35GTP biosynthetic process (GO:0006183)3.95245303
36ribonucleoprotein complex biogenesis (GO:0022613)3.91302729
37regulation of cellular amino acid metabolic process (GO:0006521)3.87998765
38negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.84584082
39negative regulation of ligase activity (GO:0051352)3.84584082
40protein complex biogenesis (GO:0070271)3.82606853
41L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.81251974
42chromatin remodeling at centromere (GO:0031055)3.75781000
43formation of translation preinitiation complex (GO:0001731)3.74102339
44cellular component biogenesis (GO:0044085)3.68665492
45protein targeting to mitochondrion (GO:0006626)3.66501962
46DNA double-strand break processing (GO:0000729)3.65611329
47UTP biosynthetic process (GO:0006228)3.64326365
48actin filament depolymerization (GO:0030042)3.62732127
49positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.60587993
50establishment of protein localization to mitochondrion (GO:0072655)3.59867412
51DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.59553943
52oxidative phosphorylation (GO:0006119)3.59413463
53protein neddylation (GO:0045116)3.58113373
54purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.54557060
55nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.51699118
56termination of RNA polymerase III transcription (GO:0006386)3.51489526
57transcription elongation from RNA polymerase III promoter (GO:0006385)3.51489526
58antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.50199945
59intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.49473862
60signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.49473862
61protein localization to mitochondrion (GO:0070585)3.49423557
62mitochondrial respiratory chain complex assembly (GO:0033108)3.48792839
63purine nucleoside triphosphate biosynthetic process (GO:0009145)3.46872596
64protein deneddylation (GO:0000338)3.46402632
65CENP-A containing nucleosome assembly (GO:0034080)3.45919896
66regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.45710452
67ATP biosynthetic process (GO:0006754)3.42931847
68signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.41909009
69signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.41909009
70signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.41909009
71intraciliary transport (GO:0042073)3.38136598
72UTP metabolic process (GO:0046051)3.37796119
73guanosine-containing compound biosynthetic process (GO:1901070)3.36063411
74signal transduction involved in DNA damage checkpoint (GO:0072422)3.35887358
75signal transduction involved in DNA integrity checkpoint (GO:0072401)3.35887358
76anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.34196216
77ribonucleoside triphosphate biosynthetic process (GO:0009201)3.31835728
78DNA damage response, detection of DNA damage (GO:0042769)3.31402444
79regulation of cilium movement (GO:0003352)3.30106877
80signal transduction involved in cell cycle checkpoint (GO:0072395)3.28334492
81exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.27674051
82nuclear-transcribed mRNA catabolic process (GO:0000956)3.26563427
83regulation of mitochondrial translation (GO:0070129)3.26321017
84CTP metabolic process (GO:0046036)3.23859627
85CTP biosynthetic process (GO:0006241)3.23859627
86sequestering of actin monomers (GO:0042989)3.23009469
87antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.20224286
88tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.19014467
89RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.19014467
90platelet dense granule organization (GO:0060155)3.17648682
91short-term memory (GO:0007614)3.15439320
92positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.14408940
93polyol transport (GO:0015791)3.13092633
94regulation of protein heterodimerization activity (GO:0043497)3.11628121
95kinetochore assembly (GO:0051382)3.10792451
96positive regulation of ligase activity (GO:0051351)3.08369222
97cullin deneddylation (GO:0010388)3.08349992
98pyrimidine nucleobase catabolic process (GO:0006208)3.07175857
99pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.05944784
100epithelial cilium movement (GO:0003351)3.04273822
101establishment of protein localization to membrane (GO:0090150)3.01901090
102mRNA catabolic process (GO:0006402)3.01492782
103metanephric tubule development (GO:0072170)2.98995112
104metanephric nephron tubule development (GO:0072234)2.98995112
105histone exchange (GO:0043486)2.98074439
106peptidyl-histidine modification (GO:0018202)2.96166168
107inner mitochondrial membrane organization (GO:0007007)2.96103265
108rRNA processing (GO:0006364)2.96005199
109positive regulation of cell cycle arrest (GO:0071158)2.95274134
110establishment of integrated proviral latency (GO:0075713)2.94618955
111resolution of meiotic recombination intermediates (GO:0000712)2.94546697
112establishment of viral latency (GO:0019043)2.92773196
113protein targeting (GO:0006605)2.90604007
114pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.89695948
115hydrogen ion transmembrane transport (GO:1902600)2.89343186
116spliceosomal snRNP assembly (GO:0000387)2.88786022
117mitochondrial transport (GO:0006839)2.86267484
118rRNA metabolic process (GO:0016072)2.85308422
119nucleoside triphosphate biosynthetic process (GO:0009142)2.83894104
120behavioral response to nicotine (GO:0035095)2.81258456
121substrate-independent telencephalic tangential migration (GO:0021826)2.79033090
122substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.79033090
123kinetochore organization (GO:0051383)2.76269232
124pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.73603063
125replication fork processing (GO:0031297)2.71498990
126DNA replication checkpoint (GO:0000076)2.66074166
127regulation of ubiquitin-protein transferase activity (GO:0051438)2.62717032
128negative regulation of telomere maintenance (GO:0032205)2.58744143
129DNA catabolic process, exonucleolytic (GO:0000738)2.58253884
130protein K6-linked ubiquitination (GO:0085020)2.57940082
1317-methylguanosine mRNA capping (GO:0006370)2.57502076
132retinal ganglion cell axon guidance (GO:0031290)2.57229880
133DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.57056920
134DNA replication-independent nucleosome assembly (GO:0006336)2.56087729
135DNA replication-independent nucleosome organization (GO:0034724)2.56087729
136regulation of ligase activity (GO:0051340)2.51626358
137protein K11-linked ubiquitination (GO:0070979)2.51314152
138base-excision repair, AP site formation (GO:0006285)2.51198060
139pyrimidine nucleotide catabolic process (GO:0006244)2.50647530
140transmission of nerve impulse (GO:0019226)2.49104609
141RNA capping (GO:0036260)2.48945799
1427-methylguanosine RNA capping (GO:0009452)2.48945799
143synaptic transmission, cholinergic (GO:0007271)2.48023536
144intracellular protein transmembrane import (GO:0044743)2.47876008
145pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.44335703
146neuron projection extension involved in neuron projection guidance (GO:1902284)2.44041198
147axon extension involved in axon guidance (GO:0048846)2.44041198
148regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.42778196
149regulation of mitotic spindle checkpoint (GO:1903504)2.42778196
150regulation of chronic inflammatory response (GO:0002676)2.41969455

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_18555785_ChIP-Seq_MESCs_Mouse4.66956416
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.56682735
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.67106069
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.58215407
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.54945214
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.48059369
7CREB1_15753290_ChIP-ChIP_HEK293T_Human3.46874778
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.42158407
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.39718831
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.16025489
11MYC_18358816_ChIP-ChIP_MESCs_Mouse3.13322076
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.99992894
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.85164330
14XRN2_22483619_ChIP-Seq_HELA_Human2.82081943
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.71207992
16* DCP1A_22483619_ChIP-Seq_HELA_Human2.58955978
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.55934248
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.55674940
19TP63_17297297_ChIP-ChIP_HaCaT_Human2.53737376
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.53658108
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.50803858
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.50529407
23* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.48620923
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.41219422
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.37041471
26CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.24552822
27EZH2_22144423_ChIP-Seq_EOC_Human2.20365467
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.15601631
29TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.14639921
30VDR_22108803_ChIP-Seq_LS180_Human2.12862820
31ELK1_22589737_ChIP-Seq_MCF10A_Human2.10192934
32E2F4_17652178_ChIP-ChIP_JURKAT_Human2.09400074
33TTF2_22483619_ChIP-Seq_HELA_Human2.08172458
34TRIM28_21343339_ChIP-Seq_HEK293_Human2.06566974
35ZNF263_19887448_ChIP-Seq_K562_Human2.06348707
36VDR_23849224_ChIP-Seq_CD4+_Human2.03121894
37ZNF274_21170338_ChIP-Seq_K562_Hela2.03080560
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.92184052
39MYC_18940864_ChIP-ChIP_HL60_Human1.90504018
40POU5F1_16153702_ChIP-ChIP_HESCs_Human1.87439035
41GABP_19822575_ChIP-Seq_HepG2_Human1.86646174
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.86035380
43EWS_26573619_Chip-Seq_HEK293_Human1.77993916
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.75232106
45ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.74847106
46FUS_26573619_Chip-Seq_HEK293_Human1.68119174
47* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.66702978
48POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.65367547
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.61111921
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.61083483
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.57410945
52E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.56500082
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49600357
54POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49539257
55KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.49123034
56TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.48750122
57FOXP3_21729870_ChIP-Seq_TREG_Human1.46964887
58ELK1_19687146_ChIP-ChIP_HELA_Human1.46846725
59SOX2_18555785_ChIP-Seq_MESCs_Mouse1.45798883
60* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.45025686
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43988538
62CLOCK_20551151_ChIP-Seq_293T_Human1.43228246
63ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.42334589
64ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42025941
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.40169078
66* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.39884085
67KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.39827481
68PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.38944189
69IGF1R_20145208_ChIP-Seq_DFB_Human1.38469676
70IRF1_19129219_ChIP-ChIP_H3396_Human1.36901056
71CTCF_18555785_ChIP-Seq_MESCs_Mouse1.35852159
72P300_19829295_ChIP-Seq_ESCs_Human1.35542989
73SOX2_16153702_ChIP-ChIP_HESCs_Human1.35221938
74STAT3_1855785_ChIP-Seq_MESCs_Mouse1.34080657
75FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33958687
76* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31874869
77NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.30389116
78ELF1_17652178_ChIP-ChIP_JURKAT_Human1.28781783
79PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28197670
80TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.26953799
81CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26034526
82CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.25640298
83NANOG_16153702_ChIP-ChIP_HESCs_Human1.24353285
84GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21900934
85HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.20938535
86FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20897746
87FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.20237409
88CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19212560
89CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.18571940
90TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17088347
91PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16721303
92RNF2_27304074_Chip-Seq_NSC_Mouse1.16701617
93KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16317272
94OCT4_18692474_ChIP-Seq_MEFs_Mouse1.16166559
95CBX2_27304074_Chip-Seq_ESCs_Mouse1.16126091
96PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.16044949
97BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.15850128
98CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.15163537
99POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12407704
100DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11683059
101MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.11236498
102ATF3_27146783_Chip-Seq_COLON_Human1.11217459
103AR_21909140_ChIP-Seq_LNCAP_Human1.11143536
104TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10930372
105ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10839920
106SOX2_18692474_ChIP-Seq_MEFs_Mouse1.09801398
107HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.09222268
108ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08337245
109BMI1_23680149_ChIP-Seq_NPCS_Mouse1.06976184
110GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.06250135
111HIF1A_21447827_ChIP-Seq_MCF-7_Human1.06219629
112EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05121382
113HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04097407
114MYCN_18555785_ChIP-Seq_MESCs_Mouse1.03821197
115* CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.03591794
116TFEB_21752829_ChIP-Seq_HELA_Human1.03530893
117POU3F2_20337985_ChIP-ChIP_501MEL_Human1.02221333
118NANOG_18555785_ChIP-Seq_MESCs_Mouse1.02068961
119RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01476320
120ELK3_25401928_ChIP-Seq_HUVEC_Human1.00767053
121PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98543464
122FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97612944
123FOXP1_21924763_ChIP-Seq_HESCs_Human0.97324493
124PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.95923375
125SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94620830
126SALL1_21062744_ChIP-ChIP_HESCs_Human0.94032849
127RBPJ_22232070_ChIP-Seq_NCS_Mouse0.93568230
128MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.92635267
129TP53_22573176_ChIP-Seq_HFKS_Human0.92429895
130KDM5A_27292631_Chip-Seq_BREAST_Human0.91910640
131YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91497765
132TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.91131347
133NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.91011459
134SMC3_22415368_ChIP-Seq_MEFs_Mouse0.90983978
135NOTCH1_21737748_ChIP-Seq_TLL_Human0.90681534
136SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90251595
137SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.89692033
138GATA1_26923725_Chip-Seq_HPCs_Mouse0.89410882
139SRY_22984422_ChIP-ChIP_TESTIS_Rat0.89102595
140NFE2_27457419_Chip-Seq_LIVER_Mouse0.89073551
141TET1_21451524_ChIP-Seq_MESCs_Mouse0.88202278
142TBX5_21415370_ChIP-Seq_HL-1_Mouse0.87368684
143* SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.85378567
144GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85365734
145CTCF_26484167_Chip-Seq_Bcells_Mouse0.85208945
146FOXA1_25329375_ChIP-Seq_VCAP_Human0.83822294
147FOXA1_27270436_Chip-Seq_PROSTATE_Human0.83822294
148PCGF2_27294783_Chip-Seq_NPCs_Mouse0.81935041
149KLF5_20875108_ChIP-Seq_MESCs_Mouse0.81037163
150EZH2_27294783_Chip-Seq_NPCs_Mouse0.80973659
151GBX2_23144817_ChIP-Seq_PC3_Human0.80587729
152SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.80584397
153IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.80122204
154CBP_20019798_ChIP-Seq_JUKART_Human0.80122204

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.71314241
2MP0008438_abnormal_cutaneous_collagen3.64175498
3MP0008789_abnormal_olfactory_epithelium3.35840838
4MP0004043_abnormal_pH_regulation3.32595524
5MP0006292_abnormal_olfactory_placode3.14649927
6MP0001529_abnormal_vocalization3.07725252
7MP0001756_abnormal_urination2.91182968
8MP0005394_taste/olfaction_phenotype2.88443876
9MP0005499_abnormal_olfactory_system2.88443876
10MP0000750_abnormal_muscle_regeneration2.87032064
11MP0003880_abnormal_central_pattern2.80420314
12MP0003136_yellow_coat_color2.69804146
13MP0010030_abnormal_orbit_morphology2.69070941
14MP0003186_abnormal_redox_activity2.63851989
15MP0003195_calcinosis2.57211427
16MP0008932_abnormal_embryonic_tissue2.41044304
17MP0001958_emphysema2.30671067
18MP0008877_abnormal_DNA_methylation2.26848500
19MP0008058_abnormal_DNA_repair2.25149803
20MP0001293_anophthalmia2.17008282
21MP0001984_abnormal_olfaction2.16299449
22MP0003693_abnormal_embryo_hatching2.04431878
23MP0004272_abnormal_basement_membrane2.01358051
24MP0003315_abnormal_perineum_morphology1.96179297
25MP0003279_aneurysm1.95890313
26MP0006036_abnormal_mitochondrial_physio1.95418424
27MP0005503_abnormal_tendon_morphology1.90706374
28MP0006276_abnormal_autonomic_nervous1.90332436
29MP0003942_abnormal_urinary_system1.88326264
30MP0006072_abnormal_retinal_apoptosis1.84213954
31MP0004957_abnormal_blastocyst_morpholog1.83683274
32MP0005623_abnormal_meninges_morphology1.83039449
33MP0003123_paternal_imprinting1.77918791
34MP0009250_abnormal_appendicular_skeleto1.75190451
35MP0003890_abnormal_embryonic-extraembry1.74049232
36MP0000534_abnormal_ureter_morphology1.72843802
37MP0001485_abnormal_pinna_reflex1.72576802
38MP0001188_hyperpigmentation1.71574726
39MP0002254_reproductive_system_inflammat1.67952117
40MP0006054_spinal_hemorrhage1.67463917
41MP0002233_abnormal_nose_morphology1.66249540
42MP0003705_abnormal_hypodermis_morpholog1.66216264
43MP0000358_abnormal_cell_content/1.61515958
44MP0001919_abnormal_reproductive_system1.59798050
45MP0000749_muscle_degeneration1.58645750
46MP0005636_abnormal_mineral_homeostasis1.53577364
47MP0000778_abnormal_nervous_system1.52706970
48MP0003121_genomic_imprinting1.48622517
49MP0001348_abnormal_lacrimal_gland1.47952108
50MP0000013_abnormal_adipose_tissue1.47914293
51MP0002282_abnormal_trachea_morphology1.43163501
52MP0009643_abnormal_urine_homeostasis1.42276708
53MP0001727_abnormal_embryo_implantation1.41690421
54MP0003119_abnormal_digestive_system1.40885029
55MP0005253_abnormal_eye_physiology1.40822027
56MP0002160_abnormal_reproductive_system1.40617455
57MP0010094_abnormal_chromosome_stability1.39537952
58MP0002751_abnormal_autonomic_nervous1.32042894
59MP0002752_abnormal_somatic_nervous1.31955828
60MP0000049_abnormal_middle_ear1.31367236
61MP0009333_abnormal_splenocyte_physiolog1.31363675
62MP0002822_catalepsy1.30205975
63MP0003937_abnormal_limbs/digits/tail_de1.28637352
64MP0005670_abnormal_white_adipose1.28294494
65MP0001881_abnormal_mammary_gland1.28102122
66MP0002938_white_spotting1.25538572
67MP0002210_abnormal_sex_determination1.24745184
68MP0000858_altered_metastatic_potential1.24721222
69MP0005389_reproductive_system_phenotype1.22995287
70MP0005084_abnormal_gallbladder_morpholo1.21310427
71MP0002184_abnormal_innervation1.19599927
72MP0002136_abnormal_kidney_physiology1.19045719
73MP0002272_abnormal_nervous_system1.18539358
74MP0000751_myopathy1.18205804
75MP0001286_abnormal_eye_development1.17906634
76MP0005275_abnormal_skin_tensile1.17476760
77MP0005508_abnormal_skeleton_morphology1.16305052
78MP0000026_abnormal_inner_ear1.15201772
79MP0000538_abnormal_urinary_bladder1.14339492
80MP0006035_abnormal_mitochondrial_morpho1.14130761
81MP0005195_abnormal_posterior_eye1.14000418
82MP0003011_delayed_dark_adaptation1.13921460
83MP0005248_abnormal_Harderian_gland1.13459494
84MP0002102_abnormal_ear_morphology1.12329612
85MP0005330_cardiomyopathy1.11681826
86MP0005332_abnormal_amino_acid1.11357369
87MP0002736_abnormal_nociception_after1.10870598
88MP0002089_abnormal_postnatal_growth/wei1.09314488
89MP0003755_abnormal_palate_morphology1.08709224
90MP0001879_abnormal_lymphatic_vessel1.08307262
91MP0005551_abnormal_eye_electrophysiolog1.08128873
92MP0003786_premature_aging1.07782501
93MP0005391_vision/eye_phenotype1.07659744
94MP0001324_abnormal_eye_pigmentation1.07553883
95MP0003787_abnormal_imprinting1.06740802
96MP0000631_abnormal_neuroendocrine_gland1.06689267
97MP0004084_abnormal_cardiac_muscle1.05577499
98MP0000647_abnormal_sebaceous_gland1.05218834
99MP0003122_maternal_imprinting1.05133090
100MP0002638_abnormal_pupillary_reflex1.04952490
101MP0003718_maternal_effect1.03812795
102MP0001542_abnormal_bone_strength1.02639224
103MP0001299_abnormal_eye_distance/1.01294855
104MP0000343_altered_response_to1.01122572
105MP0001765_abnormal_ion_homeostasis1.00020943
106MP0008775_abnormal_heart_ventricle0.99349041
107MP0004142_abnormal_muscle_tone0.98847613
108MP0000163_abnormal_cartilage_morphology0.98524542
109MP0005377_hearing/vestibular/ear_phenot0.97756617
110MP0003878_abnormal_ear_physiology0.97756617
111MP0003938_abnormal_ear_development0.96571357
112MP0005395_other_phenotype0.96378419
113MP0001145_abnormal_male_reproductive0.95816968
114MP0002249_abnormal_larynx_morphology0.94630594
115MP0000653_abnormal_sex_gland0.94579442
116MP0001968_abnormal_touch/_nociception0.94421718
117MP0002168_other_aberrant_phenotype0.94223835
118MP0002163_abnormal_gland_morphology0.93488124
119MP0005165_increased_susceptibility_to0.92933770
120MP0009745_abnormal_behavioral_response0.92661223
121MP0008007_abnormal_cellular_replicative0.92419435
122MP0000733_abnormal_muscle_development0.91724014
123MP0005023_abnormal_wound_healing0.91324854
124MP0001929_abnormal_gametogenesis0.89729436
125MP0005666_abnormal_adipose_tissue0.89369990
126MP0000759_abnormal_skeletal_muscle0.89133536
127MP0001119_abnormal_female_reproductive0.88962960
128MP0001764_abnormal_homeostasis0.88960762
129MP0002135_abnormal_kidney_morphology0.88680025
130MP0002697_abnormal_eye_size0.88573197
131MP0001963_abnormal_hearing_physiology0.88520815
132MP0002090_abnormal_vision0.88251320
133MP0001270_distended_abdomen0.88121719
134MP0000955_abnormal_spinal_cord0.87508368
135MP0009384_cardiac_valve_regurgitation0.86172773
136MP0002837_dystrophic_cardiac_calcinosis0.85958189
137MP0002653_abnormal_ependyma_morphology0.83933013
138MP0002932_abnormal_joint_morphology0.83495075
139MP0000747_muscle_weakness0.83478690
140MP0010386_abnormal_urinary_bladder0.83146227
141MP0003959_abnormal_lean_body0.82057879
142MP0003806_abnormal_nucleotide_metabolis0.81808413
143MP0001486_abnormal_startle_reflex0.81710722
144MP0003724_increased_susceptibility_to0.81610257
145MP0003698_abnormal_male_reproductive0.80677242
146MP0003077_abnormal_cell_cycle0.80657785
147MP0005197_abnormal_uvea_morphology0.80651061
148MP0000537_abnormal_urethra_morphology0.79336057
149MP0003221_abnormal_cardiomyocyte_apopto0.79189597
150MP0004858_abnormal_nervous_system0.78968068
151MP0003091_abnormal_cell_migration0.78102446
152MP0004133_heterotaxia0.78039849
153MP0003646_muscle_fatigue0.78004197
154MP0002557_abnormal_social/conspecific_i0.75509936
155MP0003950_abnormal_plasma_membrane0.74962646
156MP0003567_abnormal_fetal_cardiomyocyte0.74774700
157MP0003861_abnormal_nervous_system0.74484872
158MP0000490_abnormal_crypts_of0.74413132
159MP0004147_increased_porphyrin_level0.74224029
160MP0001905_abnormal_dopamine_level0.74015288
161MP0002234_abnormal_pharynx_morphology0.70400085
162MP0002113_abnormal_skeleton_development0.70142198
163MP0002933_joint_inflammation0.68769593
164MP0000230_abnormal_systemic_arterial0.68359331
165MP0000372_irregular_coat_pigmentation0.68259539
166MP0000627_abnormal_mammary_gland0.68250612
167MP0005375_adipose_tissue_phenotype0.67254247
168MP0000003_abnormal_adipose_tissue0.67033334
169MP0003329_amyloid_beta_deposits0.66905500
170MP0004742_abnormal_vestibular_system0.66399748

Predicted human phenotypes

RankGene SetZ-score
1Metabolic alkalosis (HP:0200114)5.97221738
2Hypokalemic alkalosis (HP:0001949)5.21331576
3Abnormality of cells of the erythroid lineage (HP:0012130)4.89740415
4Acute necrotizing encephalopathy (HP:0006965)4.64487043
5Hypomagnesemia (HP:0002917)4.61403808
6Polyuria (HP:0000103)4.57355542
7Abnormality of magnesium homeostasis (HP:0004921)4.55774891
8Abnormal mitochondria in muscle tissue (HP:0008316)4.37734496
9Hepatocellular necrosis (HP:0001404)4.28846680
10Mitochondrial inheritance (HP:0001427)4.23020447
11Abnormal urine output (HP:0012590)4.18921863
12Abnormality of chloride homeostasis (HP:0011422)3.94838113
13Renal salt wasting (HP:0000127)3.93279616
14Acute encephalopathy (HP:0006846)3.87166051
15Increased circulating renin level (HP:0000848)3.86993255
16Hepatic necrosis (HP:0002605)3.82022711
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.76357009
18Decreased activity of mitochondrial respiratory chain (HP:0008972)3.76357009
19Abnormality of renal excretion (HP:0011036)3.72830014
20Progressive macrocephaly (HP:0004481)3.72829992
21Increased CSF lactate (HP:0002490)3.72271375
22Abnormal number of erythroid precursors (HP:0012131)3.57149649
23Microvesicular hepatic steatosis (HP:0001414)3.54174938
24Increased serum pyruvate (HP:0003542)3.36843898
25Abnormality of glycolysis (HP:0004366)3.36843898
26Hyperaldosteronism (HP:0000859)3.32612023
27Hyperactive renin-angiotensin system (HP:0000841)3.21095719
28Polydipsia (HP:0001959)3.16983790
29Abnormal drinking behavior (HP:0030082)3.16983790
30Protrusio acetabuli (HP:0003179)3.14933484
31Abnormal hemoglobin (HP:0011902)3.11919189
32Exercise intolerance (HP:0003546)3.08184372
33Premature rupture of membranes (HP:0001788)3.04380667
34Molar tooth sign on MRI (HP:0002419)3.04124020
35Abnormality of midbrain morphology (HP:0002418)3.04124020
36Macrocytic anemia (HP:0001972)3.03674386
37Cerebral edema (HP:0002181)2.95497507
38Tetany (HP:0001281)2.94485805
39Reticulocytopenia (HP:0001896)2.93630135
40True hermaphroditism (HP:0010459)2.92230528
41Respiratory failure (HP:0002878)2.90300393
42Abnormality of the labia minora (HP:0012880)2.86902377
43Colon cancer (HP:0003003)2.85876635
44Alkalosis (HP:0001948)2.76133171
45Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.75677322
46Vertebral compression fractures (HP:0002953)2.75142473
47Medial flaring of the eyebrow (HP:0010747)2.71708812
48Septo-optic dysplasia (HP:0100842)2.69741917
49Lactic acidosis (HP:0003128)2.69660992
50Hyperglycinemia (HP:0002154)2.67929221
51Pallor (HP:0000980)2.66295704
52Pancreatic fibrosis (HP:0100732)2.62633540
53Increased hepatocellular lipid droplets (HP:0006565)2.54479218
54Nephrogenic diabetes insipidus (HP:0009806)2.50725551
55Multiple enchondromatosis (HP:0005701)2.49199246
56Increased serum lactate (HP:0002151)2.47898513
57Type 2 muscle fiber atrophy (HP:0003554)2.46637793
58Pancreatic cysts (HP:0001737)2.46211790
59Congenital primary aphakia (HP:0007707)2.45658682
60Gait imbalance (HP:0002141)2.45613281
61Ankle contracture (HP:0006466)2.41155235
62Lipid accumulation in hepatocytes (HP:0006561)2.36380979
63Mesangial abnormality (HP:0001966)2.36080068
64Abnormality of dentin (HP:0010299)2.35650535
65Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.34708722
66Increased muscle lipid content (HP:0009058)2.33693973
67Increased intramyocellular lipid droplets (HP:0012240)2.33645961
68CNS demyelination (HP:0007305)2.29516921
69Hypokalemia (HP:0002900)2.28369741
70Nephronophthisis (HP:0000090)2.28254157
71Anencephaly (HP:0002323)2.27968699
72Sclerocornea (HP:0000647)2.27622795
73Vaginal atresia (HP:0000148)2.26552803
74Anophthalmia (HP:0000528)2.23658650
75Aplasia/Hypoplasia of the uvula (HP:0010293)2.23334291
76Genital tract atresia (HP:0001827)2.21100735
77Cortical dysplasia (HP:0002539)2.20953591
78Neonatal short-limb short stature (HP:0008921)2.20745495
79Leukodystrophy (HP:0002415)2.19654943
80Retinal dysplasia (HP:0007973)2.16053101
81Optic nerve hypoplasia (HP:0000609)2.15116356
82Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.14893729
83Absent septum pellucidum (HP:0001331)2.13960928
84Abnormal lung lobation (HP:0002101)2.13521558
85Trismus (HP:0000211)2.13503629
86Myotonia (HP:0002486)2.12619636
87Hypoplastic pelvis (HP:0008839)2.11871673
88Meckel diverticulum (HP:0002245)2.11672466
89Abnormality of the ileum (HP:0001549)2.10420541
90Emotional lability (HP:0000712)2.09609790
91Adrenal overactivity (HP:0002717)2.09562794
92Abnormality of fatty-acid metabolism (HP:0004359)2.07484250
93Exertional dyspnea (HP:0002875)2.06678799
94Absent thumb (HP:0009777)2.03993818
95Muscle fiber atrophy (HP:0100295)2.03698239
96Cerebral hypomyelination (HP:0006808)2.00473652
97Abnormality of renal resorption (HP:0011038)1.99979101
98Optic disc pallor (HP:0000543)1.99790905
99Abnormality of renin-angiotensin system (HP:0000847)1.99599009
100Aplasia/Hypoplasia of the tongue (HP:0010295)1.99131971
101Rib fusion (HP:0000902)1.98893578
102Methylmalonic aciduria (HP:0012120)1.98457205
103Soft skin (HP:0000977)1.97965466
104X-linked dominant inheritance (HP:0001423)1.97354367
105Supernumerary spleens (HP:0009799)1.95622990
106Postaxial foot polydactyly (HP:0001830)1.95341227
107Renal Fanconi syndrome (HP:0001994)1.93786763
108Bifid tongue (HP:0010297)1.91450337
109Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.91007696
110Abnormality of sodium homeostasis (HP:0010931)1.90458871
111Postaxial hand polydactyly (HP:0001162)1.89380325
112Aplastic anemia (HP:0001915)1.87909439
1133-Methylglutaconic aciduria (HP:0003535)1.86951718
114Neuroendocrine neoplasm (HP:0100634)1.85314890
115Male pseudohermaphroditism (HP:0000037)1.85175665
116Poor suck (HP:0002033)1.84884726
117Abnormality of chromosome stability (HP:0003220)1.84109056
118Triphalangeal thumb (HP:0001199)1.83966618
119Myokymia (HP:0002411)1.83063019
120Occipital encephalocele (HP:0002085)1.82990680
121Aplasia/Hypoplasia of the sacrum (HP:0008517)1.82691081
122Rough bone trabeculation (HP:0100670)1.82606957
123Methylmalonic acidemia (HP:0002912)1.82294127
124Dicarboxylic aciduria (HP:0003215)1.81945161
125Abnormality of dicarboxylic acid metabolism (HP:0010995)1.81945161
126Preaxial hand polydactyly (HP:0001177)1.81649169
127Gonadotropin excess (HP:0000837)1.81184341
128Adrenal hypoplasia (HP:0000835)1.80756261
129Neoplasm of the peripheral nervous system (HP:0100007)1.79955752
130Pheochromocytoma (HP:0002666)1.79919261
131Microretrognathia (HP:0000308)1.78348440
132Abnormality of the renal medulla (HP:0100957)1.78017534
133Pterygium (HP:0001059)1.74632755
134Rhabdomyolysis (HP:0003201)1.74350733
135Median cleft lip (HP:0000161)1.73101737
136Abnormality of placental membranes (HP:0011409)1.71099683
137Amniotic constriction ring (HP:0009775)1.71099683
138Glossoptosis (HP:0000162)1.71086573
139Type II lissencephaly (HP:0007260)1.71041927
140Stenosis of the external auditory canal (HP:0000402)1.70825075
141Lissencephaly (HP:0001339)1.70406857
142Narrow forehead (HP:0000341)1.70279675
143Aganglionic megacolon (HP:0002251)1.69825119
144Horseshoe kidney (HP:0000085)1.69465677
145Congenital, generalized hypertrichosis (HP:0004540)1.69452582
146Metaphyseal dysplasia (HP:0100255)1.69141441
147Broad foot (HP:0001769)1.68883214
148Lethargy (HP:0001254)1.68309489
149Abnormal respiratory motile cilium physiology (HP:0012261)1.68279619
150Spinal cord compression (HP:0002176)1.66021228
151Large eyes (HP:0001090)1.65409904
152Hypoplasia of the uterus (HP:0000013)1.64673642
153Carpal bone hypoplasia (HP:0001498)1.64228487
154Chondrocalcinosis (HP:0000934)1.63994411
155Abnormal ciliary motility (HP:0012262)1.63200046
156Dandy-Walker malformation (HP:0001305)1.62962712
157Abnormality of the umbilical cord (HP:0010881)1.62770677
158Hyperparathyroidism (HP:0000843)1.61418500
159Poor head control (HP:0002421)1.60957731
160Gout (HP:0001997)1.60733439
161Short nail (HP:0001799)1.60690264
162Biconcave vertebral bodies (HP:0004586)1.60597808
163Aplasia/hypoplasia of the uterus (HP:0008684)1.59674873
164Muscle fiber splitting (HP:0003555)1.59495700
165Spinal rigidity (HP:0003306)1.59359743
166Progressive muscle weakness (HP:0003323)1.58937272

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME25.40976816
2WNK34.41954727
3TESK23.98285634
4BUB13.65501847
5LIMK13.57702761
6PIM23.39457398
7EIF2AK13.21736135
8TESK13.13411051
9TRIM282.91256857
10VRK22.75462207
11TNIK2.60732172
12ARAF2.43030094
13OXSR12.39253292
14LATS22.37744700
15WNK42.22124673
16MAP2K72.00077682
17ILK1.98160883
18LRRK21.83176841
19PNCK1.82521370
20ZAK1.77681237
21CDC71.71413127
22EIF2AK31.69891516
23WEE11.66032285
24MAP3K41.65570331
25CASK1.65343862
26CSNK1G21.60957917
27NME11.58651689
28KDR1.55018463
29MAPKAPK31.54717160
30MYLK1.53877380
31ADRBK21.51705584
32MST41.50039092
33MOS1.47604224
34SRPK11.45216642
35TRIB31.44125745
36CSNK1A1L1.42377101
37EPHA41.38917884
38TAF11.38017544
39STK161.37140500
40NUAK11.33076589
41PAK11.31455598
42MAP3K91.29990819
43BCKDK1.26993822
44TTK1.26870921
45MAP3K111.25460971
46DYRK21.24942714
47TLK11.24014108
48ABL21.21929504
49PDK31.16262885
50PDK41.16262885
51PAK21.14949315
52PBK1.13698005
53MINK11.12882123
54MAPKAPK51.11106537
55EPHB21.10563730
56GRK11.08758690
57GRK51.08562055
58PAK41.04511441
59RPS6KB21.03083964
60STK391.02592015
61PLK21.02348301
62MAP4K21.01638935
63SIK31.00895904
64ROCK21.00335755
65VRK10.97289643
66PRKCG0.96797339
67DDR20.96663636
68DAPK30.96399069
69NEK10.95531512
70BRSK20.94369370
71MKNK20.92440698
72ERN10.88948005
73GRK70.86637740
74TGFBR10.85507172
75ACVR1B0.84938389
76MARK30.82676868
77BRAF0.82522308
78MAPK130.81956209
79AURKA0.79220537
80RPS6KA40.75879457
81CDK140.75289786
82NLK0.72157671
83PTK2B0.71330535
84NEK20.69805017
85MAP3K80.68708248
86PDK20.60744603
87BRSK10.59219680
88DYRK30.57487321
89CDK150.54435520
90CDK11A0.54398733
91MAP3K120.54261044
92CDK180.53671201
93TSSK60.53513088
94PLK40.53410333
95MAP2K10.52949110
96DYRK1A0.51364989
97ERBB30.50569586
98ZAP700.48167943
99MARK10.47377757
100CSNK1G30.45906711
101AURKB0.45755381
102PRKCE0.45399127
103ROCK10.44964024
104NEK90.44820506
105MKNK10.44642662
106CCNB10.44559000
107ATR0.44366714
108ADRBK10.44156638
109CAMKK20.43612642
110TXK0.43174313
111DYRK1B0.43049010
112SCYL20.42150661
113PAK30.41308395
114PKN20.41197518
115OBSCN0.39302995
116BMPR1B0.38938968
117ERBB40.38874919
118RAF10.38806794
119PRKCI0.37771703
120CHEK20.36447749
121CDK90.35363675
122TAOK20.35149596
123PLK10.34759431
124TTN0.34688822
125MAPKAPK20.34410714
126CSNK1A10.34248581
127EIF2AK20.32860481
128CLK10.32372353
129BCR0.30694467
130PASK0.30617812
131CSNK2A10.30587094
132STK38L0.29983416
133EPHA20.29705606
134CDK80.29098778
135PLK30.28240312
136CSNK2A20.27930452
137CDK70.27485846
138PRKG20.26113998
139CDK190.25641107
140CSNK1G10.25470655
141LMTK20.25065278
142RPS6KA50.23817567
143MUSK0.23327054
144MAP2K20.22419394
145PINK10.21578837
146PDGFRA0.19784501
147FER0.15741554

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030105.84810435
2Oxidative phosphorylation_Homo sapiens_hsa001904.67743505
3Proteasome_Homo sapiens_hsa030504.66421307
4Parkinsons disease_Homo sapiens_hsa050124.50441404
5RNA polymerase_Homo sapiens_hsa030203.19795965
6Huntingtons disease_Homo sapiens_hsa050163.16014449
7Alzheimers disease_Homo sapiens_hsa050102.90563272
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.69280727
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.48045741
10Fanconi anemia pathway_Homo sapiens_hsa034602.03926467
11Pyrimidine metabolism_Homo sapiens_hsa002401.97775493
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.93026590
13Cardiac muscle contraction_Homo sapiens_hsa042601.90539949
14DNA replication_Homo sapiens_hsa030301.90164877
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.77057811
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.72127917
17Sulfur relay system_Homo sapiens_hsa041221.58582611
18Protein export_Homo sapiens_hsa030601.51605603
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48155054
20Spliceosome_Homo sapiens_hsa030401.47314385
21Non-homologous end-joining_Homo sapiens_hsa034501.46714194
22Nucleotide excision repair_Homo sapiens_hsa034201.45978649
23Carbon metabolism_Homo sapiens_hsa012001.40310690
24RNA transport_Homo sapiens_hsa030131.34607986
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.32865632
26Mismatch repair_Homo sapiens_hsa034301.27127591
27Basal cell carcinoma_Homo sapiens_hsa052171.22349546
28p53 signaling pathway_Homo sapiens_hsa041151.15991400
29Glutathione metabolism_Homo sapiens_hsa004801.14085123
30Phototransduction_Homo sapiens_hsa047441.08736920
31Pyruvate metabolism_Homo sapiens_hsa006201.05950952
32Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.05885773
33Biosynthesis of amino acids_Homo sapiens_hsa012301.04753245
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.02807801
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.02451540
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.99648706
37Bladder cancer_Homo sapiens_hsa052190.98211114
38Fatty acid elongation_Homo sapiens_hsa000620.94297703
39Purine metabolism_Homo sapiens_hsa002300.93026133
40Propanoate metabolism_Homo sapiens_hsa006400.91892228
41Pentose phosphate pathway_Homo sapiens_hsa000300.87694817
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.84710785
43Cell cycle_Homo sapiens_hsa041100.83857028
44Base excision repair_Homo sapiens_hsa034100.82915006
45Nicotine addiction_Homo sapiens_hsa050330.80354549
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80198354
47Folate biosynthesis_Homo sapiens_hsa007900.78998255
48Thyroid cancer_Homo sapiens_hsa052160.72893215
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72639771
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69378501
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68262648
52Vibrio cholerae infection_Homo sapiens_hsa051100.67380759
53Metabolic pathways_Homo sapiens_hsa011000.65113407
54Collecting duct acid secretion_Homo sapiens_hsa049660.64488359
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64162400
56Sulfur metabolism_Homo sapiens_hsa009200.63654158
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.61852668
58Epstein-Barr virus infection_Homo sapiens_hsa051690.60276189
59Cyanoamino acid metabolism_Homo sapiens_hsa004600.60160352
60Fructose and mannose metabolism_Homo sapiens_hsa000510.58774902
61Nitrogen metabolism_Homo sapiens_hsa009100.58460918
62One carbon pool by folate_Homo sapiens_hsa006700.57972407
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57956280
64Regulation of autophagy_Homo sapiens_hsa041400.57853562
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57851846
66Primary bile acid biosynthesis_Homo sapiens_hsa001200.56107455
67beta-Alanine metabolism_Homo sapiens_hsa004100.55679343
68Shigellosis_Homo sapiens_hsa051310.53850655
69ECM-receptor interaction_Homo sapiens_hsa045120.53485194
70Homologous recombination_Homo sapiens_hsa034400.52260899
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52242388
72HIF-1 signaling pathway_Homo sapiens_hsa040660.50620319
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.49954416
74Wnt signaling pathway_Homo sapiens_hsa043100.48442672
75Steroid biosynthesis_Homo sapiens_hsa001000.47149970
76Basal transcription factors_Homo sapiens_hsa030220.45448071
77RNA degradation_Homo sapiens_hsa030180.45176574
78Oocyte meiosis_Homo sapiens_hsa041140.45085823
79Viral myocarditis_Homo sapiens_hsa054160.41898886
80Tryptophan metabolism_Homo sapiens_hsa003800.41757234
81mRNA surveillance pathway_Homo sapiens_hsa030150.40897444
82Vitamin B6 metabolism_Homo sapiens_hsa007500.40399792
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40231456
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39918828
85Primary immunodeficiency_Homo sapiens_hsa053400.39622599
86Melanoma_Homo sapiens_hsa052180.37593119
87Small cell lung cancer_Homo sapiens_hsa052220.37125026
88Hedgehog signaling pathway_Homo sapiens_hsa043400.36296971
89Arginine and proline metabolism_Homo sapiens_hsa003300.35663975
90PI3K-Akt signaling pathway_Homo sapiens_hsa041510.34803156
91Phagosome_Homo sapiens_hsa041450.33291788
92Selenocompound metabolism_Homo sapiens_hsa004500.32807623
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.32493903
94Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.31908008
95TGF-beta signaling pathway_Homo sapiens_hsa043500.30925976
96Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.30855898
97Fatty acid metabolism_Homo sapiens_hsa012120.30617450
98Mineral absorption_Homo sapiens_hsa049780.29225875
99Chemical carcinogenesis_Homo sapiens_hsa052040.27618540
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.27333157
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.26530451
102Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.26437817
103Olfactory transduction_Homo sapiens_hsa047400.25828376
104Peroxisome_Homo sapiens_hsa041460.25362963
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24288445
106Arachidonic acid metabolism_Homo sapiens_hsa005900.23908668
107Hippo signaling pathway_Homo sapiens_hsa043900.22809504
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.22312376
109Autoimmune thyroid disease_Homo sapiens_hsa053200.22272284
110Apoptosis_Homo sapiens_hsa042100.22227104
111Focal adhesion_Homo sapiens_hsa045100.21399934
112Rheumatoid arthritis_Homo sapiens_hsa053230.21290480
113Axon guidance_Homo sapiens_hsa043600.21264276
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.21238727
115Proteoglycans in cancer_Homo sapiens_hsa052050.21211979
116Salmonella infection_Homo sapiens_hsa051320.20866735
117AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.20148690
118SNARE interactions in vesicular transport_Homo sapiens_hsa041300.20139366
119Pathways in cancer_Homo sapiens_hsa052000.19956103
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.19414477
121HTLV-I infection_Homo sapiens_hsa051660.19104109
122Butanoate metabolism_Homo sapiens_hsa006500.19040639
123GABAergic synapse_Homo sapiens_hsa047270.18844650
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.17019529
125Protein digestion and absorption_Homo sapiens_hsa049740.14990018
126Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.14020833
127Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.13546377
128Pentose and glucuronate interconversions_Homo sapiens_hsa000400.13298877
129Galactose metabolism_Homo sapiens_hsa000520.13112964
130Retinol metabolism_Homo sapiens_hsa008300.13047460
131Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.12606076
132Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.11423075
133Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.11199095
134Renal cell carcinoma_Homo sapiens_hsa052110.10676941
135Fatty acid degradation_Homo sapiens_hsa000710.10203349

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