

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA deamination (GO:0045006) | 4.89120463 |
| 2 | chaperone-mediated protein transport (GO:0072321) | 4.79231428 |
| 3 | proteasome assembly (GO:0043248) | 4.45170127 |
| 4 | ribosomal small subunit assembly (GO:0000028) | 4.36176100 |
| 5 | viral transcription (GO:0019083) | 4.31490866 |
| 6 | glycine metabolic process (GO:0006544) | 4.28291592 |
| 7 | serine family amino acid biosynthetic process (GO:0009070) | 4.26565487 |
| 8 | translational termination (GO:0006415) | 4.25039363 |
| 9 | maturation of SSU-rRNA (GO:0030490) | 4.23371156 |
| 10 | ribosomal large subunit biogenesis (GO:0042273) | 4.12681688 |
| 11 | ribosomal small subunit biogenesis (GO:0042274) | 4.09446043 |
| 12 | L-serine metabolic process (GO:0006563) | 4.07109179 |
| 13 | folic acid metabolic process (GO:0046655) | 4.01274760 |
| 14 | rRNA methylation (GO:0031167) | 3.94470437 |
| 15 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.92137624 |
| 16 | purine nucleobase biosynthetic process (GO:0009113) | 3.91962689 |
| 17 | establishment of integrated proviral latency (GO:0075713) | 3.87814361 |
| 18 | protein complex biogenesis (GO:0070271) | 3.86475848 |
| 19 | translational elongation (GO:0006414) | 3.86382862 |
| 20 | nucleobase biosynthetic process (GO:0046112) | 3.83134678 |
| 21 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.82185905 |
| 22 | translational initiation (GO:0006413) | 3.69532250 |
| 23 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.69494110 |
| 24 | cotranslational protein targeting to membrane (GO:0006613) | 3.62855751 |
| 25 | protein targeting to ER (GO:0045047) | 3.61442826 |
| 26 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.61252085 |
| 27 | serine family amino acid metabolic process (GO:0009069) | 3.60706006 |
| 28 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.59035520 |
| 29 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.59035520 |
| 30 | NADH dehydrogenase complex assembly (GO:0010257) | 3.59035520 |
| 31 | formation of translation preinitiation complex (GO:0001731) | 3.58949159 |
| 32 | respiratory chain complex IV assembly (GO:0008535) | 3.58463440 |
| 33 | L-methionine salvage (GO:0071267) | 3.57222066 |
| 34 | L-methionine biosynthetic process (GO:0071265) | 3.57222066 |
| 35 | amino acid salvage (GO:0043102) | 3.57222066 |
| 36 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.56578750 |
| 37 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.52231375 |
| 38 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.51539469 |
| 39 | protein localization to mitochondrion (GO:0070585) | 3.51016379 |
| 40 | L-phenylalanine metabolic process (GO:0006558) | 3.49511293 |
| 41 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 3.49511293 |
| 42 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.49380813 |
| 43 | ATP synthesis coupled proton transport (GO:0015986) | 3.49380813 |
| 44 | protein localization to endoplasmic reticulum (GO:0070972) | 3.46626835 |
| 45 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.46605170 |
| 46 | ribosome assembly (GO:0042255) | 3.46095894 |
| 47 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.41676667 |
| 48 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.40905032 |
| 49 | * translation (GO:0006412) | 3.40474047 |
| 50 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.38946833 |
| 51 | termination of RNA polymerase III transcription (GO:0006386) | 3.38946833 |
| 52 | DNA strand elongation (GO:0022616) | 3.38707179 |
| 53 | chromatin remodeling at centromere (GO:0031055) | 3.38029112 |
| 54 | cytochrome complex assembly (GO:0017004) | 3.34896770 |
| 55 | regulation of ligase activity (GO:0051340) | 3.34189335 |
| 56 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.33761384 |
| 57 | CENP-A containing nucleosome assembly (GO:0034080) | 3.33693007 |
| 58 | serine family amino acid catabolic process (GO:0009071) | 3.31281715 |
| 59 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.29603154 |
| 60 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.28494154 |
| 61 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.27559736 |
| 62 | oxidative phosphorylation (GO:0006119) | 3.26879763 |
| 63 | cellular protein complex disassembly (GO:0043624) | 3.26782610 |
| 64 | ribosome biogenesis (GO:0042254) | 3.26209572 |
| 65 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.25820381 |
| 66 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.25820381 |
| 67 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.25616723 |
| 68 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.25066601 |
| 69 | negative regulation of ligase activity (GO:0051352) | 3.25066601 |
| 70 | viral life cycle (GO:0019058) | 3.24889605 |
| 71 | DNA replication checkpoint (GO:0000076) | 3.23670968 |
| 72 | regulation of mitochondrial translation (GO:0070129) | 3.22451271 |
| 73 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.22259904 |
| 74 | maturation of 5.8S rRNA (GO:0000460) | 3.22220163 |
| 75 | IMP biosynthetic process (GO:0006188) | 3.20989168 |
| 76 | DNA damage response, detection of DNA damage (GO:0042769) | 3.20871703 |
| 77 | establishment of viral latency (GO:0019043) | 3.17999858 |
| 78 | rRNA processing (GO:0006364) | 3.17384091 |
| 79 | protein neddylation (GO:0045116) | 3.16962610 |
| 80 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.16090018 |
| 81 | cellular component biogenesis (GO:0044085) | 3.15981785 |
| 82 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.15869884 |
| 83 | L-phenylalanine catabolic process (GO:0006559) | 3.15637220 |
| 84 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 3.15637220 |
| 85 | rRNA modification (GO:0000154) | 3.14462769 |
| 86 | regulation of cellular amine metabolic process (GO:0033238) | 3.12114123 |
| 87 | transcription from mitochondrial promoter (GO:0006390) | 3.11996976 |
| 88 | sulfur amino acid biosynthetic process (GO:0000097) | 3.11932998 |
| 89 | peptidyl-histidine modification (GO:0018202) | 3.09029124 |
| 90 | DNA replication initiation (GO:0006270) | 3.07923970 |
| 91 | spliceosomal snRNP assembly (GO:0000387) | 3.07413651 |
| 92 | respiratory electron transport chain (GO:0022904) | 3.05207888 |
| 93 | pteridine-containing compound biosynthetic process (GO:0042559) | 3.04362365 |
| 94 | rRNA metabolic process (GO:0016072) | 3.04307475 |
| 95 | positive regulation of cell cycle arrest (GO:0071158) | 3.04093353 |
| 96 | mitochondrial RNA metabolic process (GO:0000959) | 3.04033354 |
| 97 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.03786640 |
| 98 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 3.00426885 |
| 99 | histone exchange (GO:0043486) | 2.99297580 |
| 100 | cysteine metabolic process (GO:0006534) | 2.97840094 |
| 101 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.97618358 |
| 102 | pseudouridine synthesis (GO:0001522) | 2.97593922 |
| 103 | mitochondrial transport (GO:0006839) | 2.97566022 |
| 104 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.97352108 |
| 105 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.97352108 |
| 106 | aldehyde catabolic process (GO:0046185) | 2.96446494 |
| 107 | electron transport chain (GO:0022900) | 2.96349518 |
| 108 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.95228147 |
| 109 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.95228147 |
| 110 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.95228147 |
| 111 | negative regulation of protein ubiquitination (GO:0031397) | 2.94930656 |
| 112 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 2.92971527 |
| 113 | transcription-coupled nucleotide-excision repair (GO:0006283) | 2.92535280 |
| 114 | glyoxylate metabolic process (GO:0046487) | 2.91819790 |
| 115 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 2.91554862 |
| 116 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.91554862 |
| 117 | G1/S transition of mitotic cell cycle (GO:0000082) | 2.91119685 |
| 118 | cell cycle G1/S phase transition (GO:0044843) | 2.91119685 |
| 119 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.89654411 |
| 120 | water-soluble vitamin biosynthetic process (GO:0042364) | 2.89459376 |
| 121 | nucleobase-containing small molecule interconversion (GO:0015949) | 2.88827582 |
| 122 | methionine biosynthetic process (GO:0009086) | 2.88451374 |
| 123 | amino acid activation (GO:0043038) | 2.88326455 |
| 124 | tRNA aminoacylation (GO:0043039) | 2.88326455 |
| 125 | positive regulation of ligase activity (GO:0051351) | 2.87535642 |
| 126 | mitotic metaphase plate congression (GO:0007080) | 2.86640227 |
| 127 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.86014571 |
| 128 | protein targeting to mitochondrion (GO:0006626) | 2.85044842 |
| 129 | cullin deneddylation (GO:0010388) | 2.83030783 |
| 130 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 2.82916575 |
| 131 | folic acid-containing compound metabolic process (GO:0006760) | 2.82522538 |
| 132 | protein deneddylation (GO:0000338) | 2.82316403 |
| 133 | methionine metabolic process (GO:0006555) | 2.81959596 |
| 134 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 2.81123174 |
| 135 | tetrahydrofolate metabolic process (GO:0046653) | 2.80824949 |
| 136 | establishment of protein localization to mitochondrion (GO:0072655) | 2.80332264 |
| 137 | telomere maintenance via recombination (GO:0000722) | 2.77537396 |
| 138 | nucleoside salvage (GO:0043174) | 2.76609472 |
| 139 | protein complex disassembly (GO:0043241) | 2.76467223 |
| 140 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 2.75090686 |
| 141 | quinone biosynthetic process (GO:1901663) | 2.70599666 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 4.76289873 |
| 2 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.10808730 |
| 3 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 4.02036213 |
| 4 | * KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.86738899 |
| 5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.46292223 |
| 6 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.37108890 |
| 7 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.33579371 |
| 8 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.29252151 |
| 9 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.21083930 |
| 10 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.17939440 |
| 11 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.12230668 |
| 12 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 3.08529830 |
| 13 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.01288085 |
| 14 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.88634992 |
| 15 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 2.78322504 |
| 16 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.71824024 |
| 17 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.69134706 |
| 18 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.47239411 |
| 19 | * XRN2_22483619_ChIP-Seq_HELA_Human | 2.29138053 |
| 20 | * DCP1A_22483619_ChIP-Seq_HELA_Human | 2.27871024 |
| 21 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.23406084 |
| 22 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.20392434 |
| 23 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.17015826 |
| 24 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.16975752 |
| 25 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.14996019 |
| 26 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.14525486 |
| 27 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 2.12911042 |
| 28 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.11086760 |
| 29 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.10109898 |
| 30 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.98392641 |
| 31 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.92385734 |
| 32 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.92373670 |
| 33 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.90987165 |
| 34 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.85340173 |
| 35 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.82948253 |
| 36 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.82409354 |
| 37 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 1.81648647 |
| 38 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 1.80616849 |
| 39 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.77978627 |
| 40 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.71760908 |
| 41 | * YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.70814291 |
| 42 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.65280193 |
| 43 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.64882547 |
| 44 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.61749261 |
| 45 | * TTF2_22483619_ChIP-Seq_HELA_Human | 1.58325146 |
| 46 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.56682026 |
| 47 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.52404069 |
| 48 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.51225237 |
| 49 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.50991104 |
| 50 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.50900376 |
| 51 | * ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.47898866 |
| 52 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.46774689 |
| 53 | * TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.44801794 |
| 54 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.43126653 |
| 55 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.39266078 |
| 56 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.39179309 |
| 57 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.39175473 |
| 58 | * TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.38895151 |
| 59 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.36701488 |
| 60 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.35510338 |
| 61 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.27117815 |
| 62 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.27053778 |
| 63 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.26809865 |
| 64 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.24538389 |
| 65 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.24098540 |
| 66 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.23341674 |
| 67 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.18802028 |
| 68 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.18193645 |
| 69 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.16251874 |
| 70 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.14813244 |
| 71 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.14716294 |
| 72 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.14143435 |
| 73 | * YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.13181832 |
| 74 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.12797296 |
| 75 | * KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.11466804 |
| 76 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.08991037 |
| 77 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.05651618 |
| 78 | * CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.04719505 |
| 79 | * HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.04482279 |
| 80 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.03350211 |
| 81 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.02495573 |
| 82 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.00728610 |
| 83 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.00225261 |
| 84 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.00019075 |
| 85 | * DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.98091769 |
| 86 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 0.96100187 |
| 87 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.95949112 |
| 88 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.95283016 |
| 89 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.94325125 |
| 90 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.94286356 |
| 91 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.93157727 |
| 92 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.92627424 |
| 93 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.92361327 |
| 94 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.92184568 |
| 95 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.92046891 |
| 96 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.90998126 |
| 97 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.89561839 |
| 98 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.88635274 |
| 99 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 0.86214936 |
| 100 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.85759086 |
| 101 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.85567296 |
| 102 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.85373645 |
| 103 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.85104704 |
| 104 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.84502728 |
| 105 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.83863373 |
| 106 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.81433500 |
| 107 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.79478944 |
| 108 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.79127397 |
| 109 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.77181234 |
| 110 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.76047114 |
| 111 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.71604232 |
| 112 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.70409986 |
| 113 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.68954671 |
| 114 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.68147770 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003806_abnormal_nucleotide_metabolis | 5.11806864 |
| 2 | MP0002139_abnormal_hepatobiliary_system | 4.20641607 |
| 3 | MP0003693_abnormal_embryo_hatching | 4.02102182 |
| 4 | MP0005360_urolithiasis | 3.99932474 |
| 5 | MP0005085_abnormal_gallbladder_physiolo | 3.24701059 |
| 6 | MP0004957_abnormal_blastocyst_morpholog | 3.19747972 |
| 7 | MP0005365_abnormal_bile_salt | 2.93944750 |
| 8 | MP0009840_abnormal_foam_cell | 2.80774355 |
| 9 | MP0003186_abnormal_redox_activity | 2.75405583 |
| 10 | MP0006036_abnormal_mitochondrial_physio | 2.66925684 |
| 11 | MP0000372_irregular_coat_pigmentation | 2.59680576 |
| 12 | MP0003111_abnormal_nucleus_morphology | 2.48256547 |
| 13 | MP0005332_abnormal_amino_acid | 2.43276951 |
| 14 | MP0003718_maternal_effect | 2.42320125 |
| 15 | MP0003077_abnormal_cell_cycle | 2.38469749 |
| 16 | MP0008875_abnormal_xenobiotic_pharmacok | 2.34636736 |
| 17 | MP0010094_abnormal_chromosome_stability | 2.11186499 |
| 18 | MP0005451_abnormal_body_composition | 2.09596663 |
| 19 | MP0005083_abnormal_biliary_tract | 2.02842134 |
| 20 | MP0008932_abnormal_embryonic_tissue | 2.00830601 |
| 21 | MP0001764_abnormal_homeostasis | 1.99799275 |
| 22 | MP0003123_paternal_imprinting | 1.95966320 |
| 23 | MP0008789_abnormal_olfactory_epithelium | 1.89912001 |
| 24 | MP0002102_abnormal_ear_morphology | 1.88649109 |
| 25 | MP0001529_abnormal_vocalization | 1.83284061 |
| 26 | MP0008057_abnormal_DNA_replication | 1.80607369 |
| 27 | MP0009379_abnormal_foot_pigmentation | 1.80309060 |
| 28 | MP0002938_white_spotting | 1.79983281 |
| 29 | MP0003195_calcinosis | 1.78196342 |
| 30 | MP0006035_abnormal_mitochondrial_morpho | 1.75238700 |
| 31 | MP0005410_abnormal_fertilization | 1.75198631 |
| 32 | MP0006292_abnormal_olfactory_placode | 1.58857946 |
| 33 | MP0003656_abnormal_erythrocyte_physiolo | 1.57598317 |
| 34 | MP0008058_abnormal_DNA_repair | 1.55211203 |
| 35 | MP0005319_abnormal_enzyme/_coenzyme | 1.52230277 |
| 36 | MP0000750_abnormal_muscle_regeneration | 1.48530755 |
| 37 | MP0001730_embryonic_growth_arrest | 1.47884774 |
| 38 | MP0003646_muscle_fatigue | 1.46452502 |
| 39 | MP0001666_abnormal_nutrient_absorption | 1.44282590 |
| 40 | MP0010329_abnormal_lipoprotein_level | 1.43937927 |
| 41 | MP0001929_abnormal_gametogenesis | 1.38005944 |
| 42 | MP0003221_abnormal_cardiomyocyte_apopto | 1.37324580 |
| 43 | MP0003252_abnormal_bile_duct | 1.36897113 |
| 44 | MP0008877_abnormal_DNA_methylation | 1.33960661 |
| 45 | MP0000609_abnormal_liver_physiology | 1.32979714 |
| 46 | MP0004019_abnormal_vitamin_homeostasis | 1.28694137 |
| 47 | MP0008995_early_reproductive_senescence | 1.28221834 |
| 48 | MP0002132_abnormal_respiratory_system | 1.28059345 |
| 49 | MP0010030_abnormal_orbit_morphology | 1.27927458 |
| 50 | MP0002163_abnormal_gland_morphology | 1.26796386 |
| 51 | MP0005330_cardiomyopathy | 1.26038527 |
| 52 | MP0009643_abnormal_urine_homeostasis | 1.25494338 |
| 53 | MP0005266_abnormal_metabolism | 1.23595918 |
| 54 | MP0003941_abnormal_skin_development | 1.22769440 |
| 55 | MP0003786_premature_aging | 1.21953310 |
| 56 | MP0002160_abnormal_reproductive_system | 1.20738396 |
| 57 | MP0005379_endocrine/exocrine_gland_phen | 1.18528767 |
| 58 | MP0005394_taste/olfaction_phenotype | 1.18413677 |
| 59 | MP0005499_abnormal_olfactory_system | 1.18413677 |
| 60 | MP0000358_abnormal_cell_content/ | 1.18361467 |
| 61 | MP0004233_abnormal_muscle_weight | 1.15587445 |
| 62 | MP0009697_abnormal_copulation | 1.13915992 |
| 63 | MP0005584_abnormal_enzyme/coenzyme_acti | 1.13353447 |
| 64 | MP0009333_abnormal_splenocyte_physiolog | 1.11949403 |
| 65 | MP0003191_abnormal_cellular_cholesterol | 1.10839593 |
| 66 | MP0008007_abnormal_cellular_replicative | 1.10762431 |
| 67 | MP0005636_abnormal_mineral_homeostasis | 1.09722752 |
| 68 | MP0001293_anophthalmia | 1.09296583 |
| 69 | MP0000350_abnormal_cell_proliferation | 1.09163762 |
| 70 | MP0004145_abnormal_muscle_electrophysio | 1.08742193 |
| 71 | MP0003011_delayed_dark_adaptation | 1.06291653 |
| 72 | MP0000598_abnormal_liver_morphology | 1.06168194 |
| 73 | MP0006072_abnormal_retinal_apoptosis | 1.05296410 |
| 74 | MP0003136_yellow_coat_color | 1.04770599 |
| 75 | MP0005670_abnormal_white_adipose | 1.03994589 |
| 76 | MP0005376_homeostasis/metabolism_phenot | 1.02246058 |
| 77 | MP0002396_abnormal_hematopoietic_system | 1.00679711 |
| 78 | MP0003698_abnormal_male_reproductive | 1.00288866 |
| 79 | MP0002118_abnormal_lipid_homeostasis | 0.99751267 |
| 80 | MP0000653_abnormal_sex_gland | 0.96222065 |
| 81 | MP0003567_abnormal_fetal_cardiomyocyte | 0.95770510 |
| 82 | MP0002234_abnormal_pharynx_morphology | 0.95388724 |
| 83 | MP0001661_extended_life_span | 0.94435354 |
| 84 | MP0001697_abnormal_embryo_size | 0.94183241 |
| 85 | MP0000490_abnormal_crypts_of | 0.92846932 |
| 86 | MP0002736_abnormal_nociception_after | 0.92199300 |
| 87 | MP0002080_prenatal_lethality | 0.92064730 |
| 88 | MP0002269_muscular_atrophy | 0.91180277 |
| 89 | MP0005395_other_phenotype | 0.87558806 |
| 90 | MP0002090_abnormal_vision | 0.86283562 |
| 91 | MP0005389_reproductive_system_phenotype | 0.86025142 |
| 92 | MP0001727_abnormal_embryo_implantation | 0.85825389 |
| 93 | MP0000749_muscle_degeneration | 0.85495861 |
| 94 | MP0002019_abnormal_tumor_incidence | 0.84770733 |
| 95 | MP0001756_abnormal_urination | 0.83961683 |
| 96 | MP0004215_abnormal_myocardial_fiber | 0.83905812 |
| 97 | MP0005380_embryogenesis_phenotype | 0.82975054 |
| 98 | MP0001672_abnormal_embryogenesis/_devel | 0.82975054 |
| 99 | MP0004147_increased_porphyrin_level | 0.82398648 |
| 100 | MP0005666_abnormal_adipose_tissue | 0.82310137 |
| 101 | MP0008260_abnormal_autophagy | 0.80905718 |
| 102 | MP0001853_heart_inflammation | 0.80073348 |
| 103 | MP0008469_abnormal_protein_level | 0.79342058 |
| 104 | MP0000313_abnormal_cell_death | 0.78772106 |
| 105 | MP0010307_abnormal_tumor_latency | 0.78672631 |
| 106 | MP0001905_abnormal_dopamine_level | 0.77824685 |
| 107 | MP0000049_abnormal_middle_ear | 0.76613875 |
| 108 | MP0003984_embryonic_growth_retardation | 0.76111565 |
| 109 | MP0000747_muscle_weakness | 0.76041084 |
| 110 | MP0005253_abnormal_eye_physiology | 0.75432667 |
| 111 | MP0002161_abnormal_fertility/fecundity | 0.74572730 |
| 112 | MP0002088_abnormal_embryonic_growth/wei | 0.74113369 |
| 113 | MP0001346_abnormal_lacrimal_gland | 0.73553589 |
| 114 | MP0003315_abnormal_perineum_morphology | 0.73356712 |
| 115 | MP0003878_abnormal_ear_physiology | 0.72646918 |
| 116 | MP0005377_hearing/vestibular/ear_phenot | 0.72646918 |
| 117 | MP0003937_abnormal_limbs/digits/tail_de | 0.71913358 |
| 118 | MP0002138_abnormal_hepatobiliary_system | 0.69769729 |
| 119 | MP0004185_abnormal_adipocyte_glucose | 0.69486749 |
| 120 | MP0005220_abnormal_exocrine_pancreas | 0.69036438 |
| 121 | MP0009763_increased_sensitivity_to | 0.67918791 |
| 122 | MP0005084_abnormal_gallbladder_morpholo | 0.67614432 |
| 123 | MP0002277_abnormal_respiratory_mucosa | 0.67184603 |
| 124 | MP0002084_abnormal_developmental_patter | 0.66857207 |
| 125 | MP0008872_abnormal_physiological_respon | 0.66074427 |
| 126 | MP0003137_abnormal_impulse_conducting | 0.65780379 |
| 127 | MP0005645_abnormal_hypothalamus_physiol | 0.65361155 |
| 128 | MP0004133_heterotaxia | 0.64988041 |
| 129 | MP0004084_abnormal_cardiac_muscle | 0.63890517 |
| 130 | MP0001119_abnormal_female_reproductive | 0.62651741 |
| 131 | MP0005501_abnormal_skin_physiology | 0.62302421 |
| 132 | MP0005075_abnormal_melanosome_morpholog | 0.62181534 |
| 133 | MP0001919_abnormal_reproductive_system | 0.61402552 |
| 134 | MP0003868_abnormal_feces_composition | 0.59406281 |
| 135 | MP0009672_abnormal_birth_weight | 0.58985792 |
| 136 | MP0002837_dystrophic_cardiac_calcinosis | 0.54374734 |
| 137 | MP0005408_hypopigmentation | 0.52639187 |
| 138 | MP0002085_abnormal_embryonic_tissue | 0.51851792 |
| 139 | MP0005647_abnormal_sex_gland | 0.51731317 |
| 140 | MP0002136_abnormal_kidney_physiology | 0.51430681 |
| 141 | MP0002210_abnormal_sex_determination | 0.51061874 |
| 142 | MP0008873_increased_physiological_sensi | 0.50711977 |
| 143 | MP0002086_abnormal_extraembryonic_tissu | 0.49877302 |
| 144 | MP0009642_abnormal_blood_homeostasis | 0.49797403 |
| 145 | MP0001145_abnormal_male_reproductive | 0.49620544 |
| 146 | MP0002332_abnormal_exercise_endurance | 0.49325399 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Hepatic necrosis (HP:0002605) | 4.26839627 |
| 2 | Hepatocellular necrosis (HP:0001404) | 4.05013448 |
| 3 | Hyperglycinuria (HP:0003108) | 3.91390313 |
| 4 | Hyperglycinemia (HP:0002154) | 3.88165331 |
| 5 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 3.87271838 |
| 6 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.83524827 |
| 7 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.83524827 |
| 8 | Abnormality of serine family amino acid metabolism (HP:0010894) | 3.79392160 |
| 9 | Abnormality of glycine metabolism (HP:0010895) | 3.79392160 |
| 10 | Increased serum pyruvate (HP:0003542) | 3.74695818 |
| 11 | Abnormality of glycolysis (HP:0004366) | 3.74695818 |
| 12 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.71092261 |
| 13 | Dicarboxylic aciduria (HP:0003215) | 3.57074021 |
| 14 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 3.57074021 |
| 15 | Multiple enchondromatosis (HP:0005701) | 3.55647288 |
| 16 | Mitochondrial inheritance (HP:0001427) | 3.54640237 |
| 17 | Increased CSF lactate (HP:0002490) | 3.52103054 |
| 18 | Acute encephalopathy (HP:0006846) | 3.49433707 |
| 19 | Abnormal number of erythroid precursors (HP:0012131) | 3.48008359 |
| 20 | Acute necrotizing encephalopathy (HP:0006965) | 3.44434707 |
| 21 | Cerebral edema (HP:0002181) | 3.43783750 |
| 22 | Increased serum lactate (HP:0002151) | 3.40697324 |
| 23 | Macrocytic anemia (HP:0001972) | 3.40696904 |
| 24 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.39728687 |
| 25 | Cerebral hypomyelination (HP:0006808) | 3.31446771 |
| 26 | Hypobetalipoproteinemia (HP:0003563) | 3.30668999 |
| 27 | Abnormality of fatty-acid metabolism (HP:0004359) | 3.23616570 |
| 28 | Lipid accumulation in hepatocytes (HP:0006561) | 3.23030863 |
| 29 | Lethargy (HP:0001254) | 3.21244267 |
| 30 | Lactic acidosis (HP:0003128) | 3.17140108 |
| 31 | Increased intramyocellular lipid droplets (HP:0012240) | 3.16333959 |
| 32 | Increased muscle lipid content (HP:0009058) | 3.14933930 |
| 33 | Reticulocytopenia (HP:0001896) | 3.14134674 |
| 34 | Hyperammonemia (HP:0001987) | 3.13786629 |
| 35 | Increased hepatocellular lipid droplets (HP:0006565) | 3.10480902 |
| 36 | Oral leukoplakia (HP:0002745) | 3.08656914 |
| 37 | Abnormality of serum amino acid levels (HP:0003112) | 3.08275768 |
| 38 | Breast hypoplasia (HP:0003187) | 3.01262172 |
| 39 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 3.01013674 |
| 40 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.98857454 |
| 41 | CNS demyelination (HP:0007305) | 2.94358017 |
| 42 | 3-Methylglutaconic aciduria (HP:0003535) | 2.91332294 |
| 43 | Rhabdomyolysis (HP:0003201) | 2.87482083 |
| 44 | Type I transferrin isoform profile (HP:0003642) | 2.84973531 |
| 45 | Birth length less than 3rd percentile (HP:0003561) | 2.84784772 |
| 46 | Intrahepatic cholestasis (HP:0001406) | 2.83839715 |
| 47 | Respiratory failure (HP:0002878) | 2.77867397 |
| 48 | Nausea (HP:0002018) | 2.75197337 |
| 49 | Megaloblastic anemia (HP:0001889) | 2.70363849 |
| 50 | Methylmalonic aciduria (HP:0012120) | 2.69552687 |
| 51 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.69275344 |
| 52 | Aplastic anemia (HP:0001915) | 2.65353091 |
| 53 | Abnormality of pyrimidine metabolism (HP:0004353) | 2.64756189 |
| 54 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 2.62560216 |
| 55 | Hypoglycemic coma (HP:0001325) | 2.59683461 |
| 56 | Progressive macrocephaly (HP:0004481) | 2.59628648 |
| 57 | Abnormality of methionine metabolism (HP:0010901) | 2.56097696 |
| 58 | Optic disc pallor (HP:0000543) | 2.53748801 |
| 59 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.53380220 |
| 60 | Xanthomatosis (HP:0000991) | 2.53131929 |
| 61 | Exercise intolerance (HP:0003546) | 2.46495521 |
| 62 | Microretrognathia (HP:0000308) | 2.38984424 |
| 63 | Pallor (HP:0000980) | 2.38209875 |
| 64 | Ketosis (HP:0001946) | 2.36842194 |
| 65 | Glycosuria (HP:0003076) | 2.34741246 |
| 66 | Abnormality of urine glucose concentration (HP:0011016) | 2.34741246 |
| 67 | Reduced antithrombin III activity (HP:0001976) | 2.33798085 |
| 68 | Renal Fanconi syndrome (HP:0001994) | 2.31291235 |
| 69 | Delayed CNS myelination (HP:0002188) | 2.31049913 |
| 70 | Rough bone trabeculation (HP:0100670) | 2.29436314 |
| 71 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.29174476 |
| 72 | Deep venous thrombosis (HP:0002625) | 2.26120338 |
| 73 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.24710707 |
| 74 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.24006885 |
| 75 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.24006885 |
| 76 | Abnormal protein glycosylation (HP:0012346) | 2.24006885 |
| 77 | Abnormal glycosylation (HP:0012345) | 2.24006885 |
| 78 | Ileus (HP:0002595) | 2.22448963 |
| 79 | Proximal tubulopathy (HP:0000114) | 2.21864749 |
| 80 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 2.21227873 |
| 81 | Trismus (HP:0000211) | 2.19713901 |
| 82 | Hypolipoproteinemia (HP:0010981) | 2.17210603 |
| 83 | Gout (HP:0001997) | 2.16877213 |
| 84 | Meckel diverticulum (HP:0002245) | 2.15616518 |
| 85 | Metabolic acidosis (HP:0001942) | 2.14818443 |
| 86 | Progressive muscle weakness (HP:0003323) | 2.14447254 |
| 87 | Secondary amenorrhea (HP:0000869) | 2.14243565 |
| 88 | Microvesicular hepatic steatosis (HP:0001414) | 2.13832514 |
| 89 | Type 2 muscle fiber atrophy (HP:0003554) | 2.13589588 |
| 90 | Abnormal cartilage morphology (HP:0002763) | 2.13300868 |
| 91 | Generalized aminoaciduria (HP:0002909) | 2.12526269 |
| 92 | Abnormality of the ileum (HP:0001549) | 2.09822888 |
| 93 | Abnormality of the preputium (HP:0100587) | 2.08472641 |
| 94 | Spastic paraparesis (HP:0002313) | 2.08029110 |
| 95 | Exertional dyspnea (HP:0002875) | 2.07401683 |
| 96 | Ragged-red muscle fibers (HP:0003200) | 2.06920223 |
| 97 | Methylmalonic acidemia (HP:0002912) | 2.05959095 |
| 98 | Hyperlipoproteinemia (HP:0010980) | 2.05646806 |
| 99 | Respiratory difficulties (HP:0002880) | 2.05250700 |
| 100 | Abnormality of renal resorption (HP:0011038) | 2.04715402 |
| 101 | Abnormality of the anterior horn cell (HP:0006802) | 2.04217089 |
| 102 | Degeneration of anterior horn cells (HP:0002398) | 2.04217089 |
| 103 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 2.04061632 |
| 104 | Emotional lability (HP:0000712) | 2.03828265 |
| 105 | Vomiting (HP:0002013) | 2.03137882 |
| 106 | Muscle fiber atrophy (HP:0100295) | 2.02846515 |
| 107 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.01881776 |
| 108 | Abnormality of alanine metabolism (HP:0010916) | 2.01881776 |
| 109 | Hyperalaninemia (HP:0003348) | 2.01881776 |
| 110 | Abnormality of placental membranes (HP:0011409) | 2.01158337 |
| 111 | Amniotic constriction ring (HP:0009775) | 2.01158337 |
| 112 | Chromsome breakage (HP:0040012) | 2.00916079 |
| 113 | Myoglobinuria (HP:0002913) | 2.00494801 |
| 114 | Leukodystrophy (HP:0002415) | 2.00039817 |
| 115 | Opisthotonus (HP:0002179) | 1.99415851 |
| 116 | Sparse eyelashes (HP:0000653) | 1.96478442 |
| 117 | Brushfield spots (HP:0001088) | 1.96279824 |
| 118 | Prolonged partial thromboplastin time (HP:0003645) | 1.94298929 |
| 119 | Pancytopenia (HP:0001876) | 1.94125335 |
| 120 | Carpal bone hypoplasia (HP:0001498) | 1.93692232 |
| 121 | Abnormality of nucleobase metabolism (HP:0010932) | 1.91708087 |
| 122 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.91692467 |
| 123 | Nemaline bodies (HP:0003798) | 1.89602176 |
| 124 | Abnormality of the level of lipoprotein cholesterol (HP:0010979) | 1.88429686 |
| 125 | X-linked dominant inheritance (HP:0001423) | 1.87589945 |
| 126 | Abnormality of the labia minora (HP:0012880) | 1.83947575 |
| 127 | Neoplasm of the adrenal gland (HP:0100631) | 1.74948806 |
| 128 | Hyperphosphaturia (HP:0003109) | 1.72991834 |
| 129 | Abnormal lung lobation (HP:0002101) | 1.71096325 |
| 130 | Colon cancer (HP:0003003) | 1.70412941 |
| 131 | Facial cleft (HP:0002006) | 1.69466676 |
| 132 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.68913302 |
| 133 | Poor suck (HP:0002033) | 1.67712746 |
| 134 | Muscle fiber inclusion bodies (HP:0100299) | 1.67669442 |
| 135 | Blindness (HP:0000618) | 1.67346442 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 5.02202858 |
| 2 | NME2 | 4.41155918 |
| 3 | BCKDK | 4.14557756 |
| 4 | VRK2 | 4.12646153 |
| 5 | EIF2AK1 | 3.95436613 |
| 6 | WEE1 | 3.38683295 |
| 7 | STK16 | 3.20172469 |
| 8 | TESK2 | 2.81242234 |
| 9 | TLK1 | 2.30719916 |
| 10 | EIF2AK3 | 2.13305289 |
| 11 | PBK | 1.81504114 |
| 12 | NME1 | 1.79764220 |
| 13 | CDC7 | 1.69646426 |
| 14 | KDR | 1.67002531 |
| 15 | DYRK3 | 1.63693618 |
| 16 | NEK1 | 1.62017156 |
| 17 | TRIM28 | 1.61828713 |
| 18 | STK38L | 1.61298349 |
| 19 | BRSK2 | 1.60756385 |
| 20 | ARAF | 1.59341723 |
| 21 | TTK | 1.56386324 |
| 22 | PIM2 | 1.55671769 |
| 23 | BMPR1B | 1.53169791 |
| 24 | BRAF | 1.50898224 |
| 25 | SRPK1 | 1.50779159 |
| 26 | MAP4K2 | 1.49206399 |
| 27 | NEK2 | 1.46329668 |
| 28 | PLK4 | 1.42682863 |
| 29 | VRK1 | 1.35400818 |
| 30 | PLK1 | 1.34925183 |
| 31 | RPS6KA4 | 1.34266944 |
| 32 | ACVR1B | 1.30629135 |
| 33 | MAP3K11 | 1.28481269 |
| 34 | MST4 | 1.28099974 |
| 35 | IRAK3 | 1.27866415 |
| 36 | TSSK6 | 1.25757577 |
| 37 | AURKA | 1.23332582 |
| 38 | ABL2 | 1.21422549 |
| 39 | ILK | 1.18150700 |
| 40 | EPHA2 | 1.17627086 |
| 41 | MAP2K2 | 1.14902730 |
| 42 | CCNB1 | 1.14796748 |
| 43 | AURKB | 1.14552026 |
| 44 | MAP3K12 | 1.11866339 |
| 45 | MAP3K8 | 1.10553328 |
| 46 | LIMK1 | 1.08174617 |
| 47 | NUAK1 | 1.06519268 |
| 48 | CDK8 | 1.05668988 |
| 49 | MUSK | 0.99706453 |
| 50 | WNK3 | 0.99653790 |
| 51 | SCYL2 | 0.97439582 |
| 52 | CDK4 | 0.95898198 |
| 53 | DAPK1 | 0.95172537 |
| 54 | PAK1 | 0.87875127 |
| 55 | PLK2 | 0.87222925 |
| 56 | ZAK | 0.86982272 |
| 57 | RPS6KB2 | 0.84816264 |
| 58 | CDK7 | 0.84777330 |
| 59 | BRSK1 | 0.84750777 |
| 60 | ERN1 | 0.80351622 |
| 61 | OBSCN | 0.80299560 |
| 62 | BLK | 0.79788064 |
| 63 | CDK19 | 0.78587523 |
| 64 | PDK3 | 0.76686994 |
| 65 | PDK4 | 0.76686994 |
| 66 | LRRK2 | 0.75598710 |
| 67 | RAF1 | 0.74444927 |
| 68 | PHKG2 | 0.74204033 |
| 69 | PHKG1 | 0.74204033 |
| 70 | MST1R | 0.74027752 |
| 71 | TESK1 | 0.73842202 |
| 72 | MAP2K3 | 0.72108095 |
| 73 | MKNK1 | 0.70976142 |
| 74 | CSNK1A1L | 0.70893015 |
| 75 | CSNK2A1 | 0.69591704 |
| 76 | CSNK1G2 | 0.69522396 |
| 77 | NEK9 | 0.69402068 |
| 78 | RPS6KA5 | 0.68560523 |
| 79 | MAP3K3 | 0.65222738 |
| 80 | STK4 | 0.64687494 |
| 81 | PAK4 | 0.64374465 |
| 82 | CHEK2 | 0.63323326 |
| 83 | PLK3 | 0.62927807 |
| 84 | CSNK2A2 | 0.62728345 |
| 85 | TAF1 | 0.61153282 |
| 86 | GRK1 | 0.59848385 |
| 87 | ERBB3 | 0.59244167 |
| 88 | PRKCI | 0.57824230 |
| 89 | INSRR | 0.57803507 |
| 90 | PIK3CG | 0.57506217 |
| 91 | TAOK2 | 0.52096904 |
| 92 | DYRK2 | 0.51706283 |
| 93 | PDK2 | 0.51305431 |
| 94 | ATM | 0.50867154 |
| 95 | OXSR1 | 0.49331795 |
| 96 | ATR | 0.48871577 |
| 97 | ERBB4 | 0.48500289 |
| 98 | CSNK1G3 | 0.46982951 |
| 99 | WNK4 | 0.46930442 |
| 100 | DAPK3 | 0.46599015 |
| 101 | TEC | 0.46011874 |
| 102 | BCR | 0.45726429 |
| 103 | STK39 | 0.44362733 |
| 104 | MAPKAPK3 | 0.43986471 |
| 105 | LATS2 | 0.42224214 |
| 106 | PIK3CA | 0.41667625 |
| 107 | MAPK11 | 0.40236090 |
| 108 | MAP4K1 | 0.39516151 |
| 109 | MAP2K7 | 0.39469562 |
| 110 | MYLK | 0.38669386 |
| 111 | STK10 | 0.36528442 |
| 112 | CHEK1 | 0.36159846 |
| 113 | CDK1 | 0.34729040 |
| 114 | CSNK1E | 0.33665251 |
| 115 | ALK | 0.33393100 |
| 116 | PIM1 | 0.32990895 |
| 117 | CSNK1G1 | 0.32236698 |
| 118 | MKNK2 | 0.31389526 |
| 119 | CDK2 | 0.30743368 |
| 120 | TIE1 | 0.30358566 |
| 121 | ADRBK2 | 0.29047926 |
| 122 | CSNK1A1 | 0.28812800 |
| 123 | CAMK2D | 0.27226008 |
| 124 | TRIB3 | 0.25846832 |
| 125 | TGFBR1 | 0.23851177 |
| 126 | TTN | 0.23534285 |
| 127 | TYK2 | 0.23089157 |
| 128 | PASK | 0.22987552 |
| 129 | AKT2 | 0.22182062 |
| 130 | EIF2AK2 | 0.21341629 |
| 131 | CAMK2G | 0.21273118 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | * Ribosome_Homo sapiens_hsa03010 | 3.44515466 |
| 2 | Proteasome_Homo sapiens_hsa03050 | 3.31460900 |
| 3 | DNA replication_Homo sapiens_hsa03030 | 2.82282795 |
| 4 | RNA polymerase_Homo sapiens_hsa03020 | 2.60862429 |
| 5 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 2.36281955 |
| 6 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 2.31101078 |
| 7 | Mismatch repair_Homo sapiens_hsa03430 | 2.29357637 |
| 8 | Folate biosynthesis_Homo sapiens_hsa00790 | 2.15137661 |
| 9 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.15047422 |
| 10 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.07951478 |
| 11 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.04180549 |
| 12 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.97552297 |
| 13 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.95149399 |
| 14 | Parkinsons disease_Homo sapiens_hsa05012 | 1.90083122 |
| 15 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.87564248 |
| 16 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.85049710 |
| 17 | Sulfur relay system_Homo sapiens_hsa04122 | 1.77432066 |
| 18 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.72616820 |
| 19 | Carbon metabolism_Homo sapiens_hsa01200 | 1.71561261 |
| 20 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 1.70960542 |
| 21 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.68710810 |
| 22 | Homologous recombination_Homo sapiens_hsa03440 | 1.63684697 |
| 23 | Spliceosome_Homo sapiens_hsa03040 | 1.61569420 |
| 24 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.57788041 |
| 25 | Fatty acid degradation_Homo sapiens_hsa00071 | 1.56740329 |
| 26 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.55423486 |
| 27 | RNA transport_Homo sapiens_hsa03013 | 1.54402500 |
| 28 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.53063530 |
| 29 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.50691629 |
| 30 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.49217753 |
| 31 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.48767836 |
| 32 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.46677706 |
| 33 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 1.43979139 |
| 34 | Base excision repair_Homo sapiens_hsa03410 | 1.43780799 |
| 35 | Peroxisome_Homo sapiens_hsa04146 | 1.39579372 |
| 36 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.39349223 |
| 37 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.39317925 |
| 38 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.36783741 |
| 39 | Huntingtons disease_Homo sapiens_hsa05016 | 1.35921225 |
| 40 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.33009714 |
| 41 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.30350984 |
| 42 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.29969998 |
| 43 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.29171678 |
| 44 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.27680391 |
| 45 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.27264649 |
| 46 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.23269797 |
| 47 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 1.21364525 |
| 48 | Protein export_Homo sapiens_hsa03060 | 1.19903446 |
| 49 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 1.19315809 |
| 50 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.15372615 |
| 51 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.14782276 |
| 52 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 1.11418210 |
| 53 | Arginine biosynthesis_Homo sapiens_hsa00220 | 1.09351739 |
| 54 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.09347681 |
| 55 | Alzheimers disease_Homo sapiens_hsa05010 | 1.06005859 |
| 56 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.05133063 |
| 57 | Purine metabolism_Homo sapiens_hsa00230 | 0.98232356 |
| 58 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.97934644 |
| 59 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.93063582 |
| 60 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.90655264 |
| 61 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.89977908 |
| 62 | Cell cycle_Homo sapiens_hsa04110 | 0.87282038 |
| 63 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.85463345 |
| 64 | Metabolic pathways_Homo sapiens_hsa01100 | 0.85363562 |
| 65 | Basal transcription factors_Homo sapiens_hsa03022 | 0.84542559 |
| 66 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.84407043 |
| 67 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.82131862 |
| 68 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.80762776 |
| 69 | Histidine metabolism_Homo sapiens_hsa00340 | 0.80240369 |
| 70 | Retinol metabolism_Homo sapiens_hsa00830 | 0.79138154 |
| 71 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.78892243 |
| 72 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.76159813 |
| 73 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.74352835 |
| 74 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.74341791 |
| 75 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.72554806 |
| 76 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.69770100 |
| 77 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.67921803 |
| 78 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.65572367 |
| 79 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.64487163 |
| 80 | RNA degradation_Homo sapiens_hsa03018 | 0.63998957 |
| 81 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.63146758 |
| 82 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.62956172 |
| 83 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.60250891 |
| 84 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.56458740 |
| 85 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.51488907 |
| 86 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.49609866 |
| 87 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.48684406 |
| 88 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.47945955 |
| 89 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.46525270 |
| 90 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.44352152 |
| 91 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.43451296 |
| 92 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.42665043 |
| 93 | Galactose metabolism_Homo sapiens_hsa00052 | 0.36525985 |
| 94 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.36477033 |
| 95 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.36173509 |
| 96 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.35259987 |
| 97 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.34949999 |
| 98 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.34874571 |
| 99 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.30345274 |
| 100 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.27711708 |
| 101 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.27061047 |
| 102 | Phototransduction_Homo sapiens_hsa04744 | 0.27002192 |
| 103 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.26996006 |
| 104 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.25120699 |
| 105 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.25014380 |
| 106 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.23970905 |
| 107 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.18994468 |
| 108 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.17947629 |
| 109 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.15112728 |
| 110 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.12388969 |

