MRRF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a ribosome recycling factor, which is a component of the mitochondrial translational machinery. The encoded protein, along with mitochondrial elongation factor 2, functions in ribosomal recycling at the termination of mitochondrial translation by mediating the disassembly of ribosomes from messenger RNA. A pseudogene of this gene has been identified on chromosome X. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.24350716
2ribosomal small subunit assembly (GO:0000028)5.13394911
3oxidative phosphorylation (GO:0006119)4.89709479
4energy coupled proton transport, down electrochemical gradient (GO:0015985)4.64420106
5ATP synthesis coupled proton transport (GO:0015986)4.64420106
6sphingosine metabolic process (GO:0006670)4.64040371
7maturation of SSU-rRNA (GO:0030490)4.59926413
8DNA deamination (GO:0045006)4.51466999
9diol metabolic process (GO:0034311)4.39647372
10viral transcription (GO:0019083)4.29368898
11translational termination (GO:0006415)4.28363358
12sphingoid metabolic process (GO:0046519)4.10605081
13respiratory electron transport chain (GO:0022904)4.08855114
14DNA methylation involved in gamete generation (GO:0043046)4.07466061
15mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.03573779
16electron transport chain (GO:0022900)3.99941279
17cullin deneddylation (GO:0010388)3.94360368
18ribosomal large subunit biogenesis (GO:0042273)3.94212008
19piRNA metabolic process (GO:0034587)3.93992963
20translational elongation (GO:0006414)3.91466230
21regulation of mitochondrial translation (GO:0070129)3.88505480
22tricarboxylic acid cycle (GO:0006099)3.85337530
23centriole replication (GO:0007099)3.84691799
24SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.83969431
25ubiquinone biosynthetic process (GO:0006744)3.82379913
26quinone biosynthetic process (GO:1901663)3.82379913
27regulation of meiosis I (GO:0060631)3.80572686
28protein deneddylation (GO:0000338)3.80249965
29cotranslational protein targeting to membrane (GO:0006613)3.75674016
30formation of translation preinitiation complex (GO:0001731)3.73679534
31respiratory chain complex IV assembly (GO:0008535)3.73615226
32purine nucleobase biosynthetic process (GO:0009113)3.73366827
33protein targeting to ER (GO:0045047)3.72325778
34proteasome assembly (GO:0043248)3.68502509
35NADH dehydrogenase complex assembly (GO:0010257)3.68426793
36mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.68426793
37mitochondrial respiratory chain complex I assembly (GO:0032981)3.68426793
38ribosomal small subunit biogenesis (GO:0042274)3.63934826
39protein complex biogenesis (GO:0070271)3.60087969
40aerobic respiration (GO:0009060)3.59850854
41protein localization to endoplasmic reticulum (GO:0070972)3.59317932
42translational initiation (GO:0006413)3.58080829
43rRNA methylation (GO:0031167)3.57708309
44nucleobase biosynthetic process (GO:0046112)3.56481190
45DNA replication checkpoint (GO:0000076)3.55750360
46mitochondrial respiratory chain complex assembly (GO:0033108)3.51936051
47establishment of protein localization to endoplasmic reticulum (GO:0072599)3.51778577
48* translation (GO:0006412)3.44027584
49deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.43132886
50negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.42710297
51meiotic chromosome segregation (GO:0045132)3.42702848
52negative regulation of DNA-dependent DNA replication (GO:2000104)3.42662299
53pseudouridine synthesis (GO:0001522)3.41509007
54inner mitochondrial membrane organization (GO:0007007)3.40711144
55L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.39384114
56ubiquinone metabolic process (GO:0006743)3.36935160
57ribonucleoprotein complex biogenesis (GO:0022613)3.36074364
58reciprocal DNA recombination (GO:0035825)3.36043435
59reciprocal meiotic recombination (GO:0007131)3.36043435
60viral life cycle (GO:0019058)3.34971270
61cellular protein complex disassembly (GO:0043624)3.29539063
62regulation of nuclear cell cycle DNA replication (GO:0033262)3.28005614
63nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.26517372
64regulation of cellular amino acid metabolic process (GO:0006521)3.25784810
65cellular component biogenesis (GO:0044085)3.25716427
66L-methionine salvage (GO:0071267)3.22292507
67L-methionine biosynthetic process (GO:0071265)3.22292507
68amino acid salvage (GO:0043102)3.22292507
69positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.21961301
70negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.21625655
71transcription elongation from RNA polymerase III promoter (GO:0006385)3.21335105
72termination of RNA polymerase III transcription (GO:0006386)3.21335105
73mitochondrial RNA metabolic process (GO:0000959)3.17274180
74water-soluble vitamin biosynthetic process (GO:0042364)3.16349605
75regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.14818639
76cytochrome complex assembly (GO:0017004)3.13257153
77double-strand break repair via homologous recombination (GO:0000724)3.12898035
78recombinational repair (GO:0000725)3.11183073
79negative regulation of ligase activity (GO:0051352)3.10806122
80negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.10806122
81spliceosomal snRNP assembly (GO:0000387)3.09968769
82DNA strand elongation involved in DNA replication (GO:0006271)3.09526917
83ribosome biogenesis (GO:0042254)3.08291198
84cellular respiration (GO:0045333)3.06918937
85establishment of protein localization to mitochondrial membrane (GO:0090151)3.06446272
86protein K6-linked ubiquitination (GO:0085020)3.06288609
87iron-sulfur cluster assembly (GO:0016226)3.06012808
88metallo-sulfur cluster assembly (GO:0031163)3.06012808
89oxaloacetate metabolic process (GO:0006107)3.05288805
90telomere maintenance via semi-conservative replication (GO:0032201)3.05105426
91anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.04364313
92lysine metabolic process (GO:0006553)3.03999173
93lysine catabolic process (GO:0006554)3.03999173
94NADH metabolic process (GO:0006734)3.02471520
95guanosine-containing compound biosynthetic process (GO:1901070)2.98759967
96DNA double-strand break processing (GO:0000729)2.97395336
97glycine metabolic process (GO:0006544)2.95247534
98peptidyl-histidine modification (GO:0018202)2.95070627
99centriole assembly (GO:0098534)2.94687963
100DNA strand elongation (GO:0022616)2.92664862
101positive regulation of developmental pigmentation (GO:0048087)2.92410146
102regulation of centriole replication (GO:0046599)2.92346554
103nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.91508439
104DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.91475614
105tetrahydrofolate metabolic process (GO:0046653)2.90982116
106folic acid-containing compound biosynthetic process (GO:0009396)2.90816569
107folic acid metabolic process (GO:0046655)2.90529379
108somatic hypermutation of immunoglobulin genes (GO:0016446)2.89064677
109somatic diversification of immune receptors via somatic mutation (GO:0002566)2.89064677
110transcription from mitochondrial promoter (GO:0006390)2.88417867
111pteridine-containing compound biosynthetic process (GO:0042559)2.88076543
112signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.86004411
113intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.86004411
114protein complex disassembly (GO:0043241)2.85888824
115exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.84778988
116rRNA modification (GO:0000154)2.84049727
117purine nucleoside triphosphate biosynthetic process (GO:0009145)2.83851580
118synapsis (GO:0007129)2.83741354
119tRNA processing (GO:0008033)2.83307018
120positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.83243097
121erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.82856095
122L-phenylalanine metabolic process (GO:0006558)2.82856095
123AMP metabolic process (GO:0046033)2.82791660
124signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.81980826
125signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.81980826
126signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.81980826
127regulation of mitotic spindle checkpoint (GO:1903504)2.81453716
128regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.81453716
1297-methylguanosine mRNA capping (GO:0006370)2.81049683
130protein targeting to mitochondrion (GO:0006626)2.80943497
131GTP biosynthetic process (GO:0006183)2.80930773
132CENP-A containing nucleosome assembly (GO:0034080)2.80325031
133rRNA processing (GO:0006364)2.79717470
134purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.79463491
135tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.79394053
136RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.79394053
137ATP biosynthetic process (GO:0006754)2.79044267
138nucleoside salvage (GO:0043174)2.79029557
139tRNA metabolic process (GO:0006399)2.78075688
140chromatin remodeling at centromere (GO:0031055)2.76060728
141nucleotide-excision repair, DNA gap filling (GO:0006297)2.76008964
142negative regulation of cell cycle G2/M phase transition (GO:1902750)2.75672582
143replication fork processing (GO:0031297)2.74540553
144methionine biosynthetic process (GO:0009086)2.73779086
145ribosome assembly (GO:0042255)2.72443539
146regulation of centrosome cycle (GO:0046605)2.71665202
147tRNA aminoacylation (GO:0043039)2.70043211
148amino acid activation (GO:0043038)2.70043211
149mitotic recombination (GO:0006312)2.68768271
150lipopolysaccharide biosynthetic process (GO:0009103)2.66330748
151tRNA aminoacylation for protein translation (GO:0006418)2.64640700
152regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.63840121
153rRNA metabolic process (GO:0016072)2.62680538
154mannosylation (GO:0097502)2.60808112
155DNA catabolic process, exonucleolytic (GO:0000738)2.60393102
156telomere maintenance via recombination (GO:0000722)2.60296410
157regulation of centrosome duplication (GO:0010824)2.59919287
158male meiosis I (GO:0007141)2.59208859
159ncRNA metabolic process (GO:0034660)2.58264095
160double-strand break repair via nonhomologous end joining (GO:0006303)2.57845098
161non-recombinational repair (GO:0000726)2.57845098
162cellular ketone body metabolic process (GO:0046950)2.57608140
163regulation of DNA endoreduplication (GO:0032875)2.57297393
164somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.54201496
165somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.54201496
166isotype switching (GO:0045190)2.54201496

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_18555785_ChIP-Seq_MESCs_Mouse4.45411981
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.40280187
3E2F7_22180533_ChIP-Seq_HELA_Human4.17878166
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.16559329
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.80750612
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.80257605
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.68882384
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.39549725
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.23306359
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.12389562
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.95175958
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.78503439
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.78178576
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.73220698
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.68121386
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.66825690
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.63967616
18DCP1A_22483619_ChIP-Seq_HELA_Human2.53443104
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.53363980
20* SRF_21415370_ChIP-Seq_HL-1_Mouse2.41690581
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.40702563
22VDR_23849224_ChIP-Seq_CD4+_Human2.39656990
23E2F1_18555785_ChIP-Seq_MESCs_Mouse2.38271750
24ZNF274_21170338_ChIP-Seq_K562_Hela2.37038800
25RBPJ_22232070_ChIP-Seq_NCS_Mouse2.32456836
26XRN2_22483619_ChIP-Seq_HELA_Human2.27195898
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.23611285
28VDR_22108803_ChIP-Seq_LS180_Human2.22792041
29SALL1_21062744_ChIP-ChIP_HESCs_Human2.21646124
30FOXP3_21729870_ChIP-Seq_TREG_Human2.20744068
31ELF1_17652178_ChIP-ChIP_JURKAT_Human2.20539526
32E2F4_17652178_ChIP-ChIP_JURKAT_Human2.14803554
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.14417950
34IGF1R_20145208_ChIP-Seq_DFB_Human2.13557348
35THAP11_20581084_ChIP-Seq_MESCs_Mouse2.11639612
36E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.11215027
37NELFA_20434984_ChIP-Seq_ESCs_Mouse2.10604294
38GABP_19822575_ChIP-Seq_HepG2_Human2.08856888
39CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.06061157
40* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93113740
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.91101890
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.88757532
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.85380929
44* TTF2_22483619_ChIP-Seq_HELA_Human1.83641623
45MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.77327873
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.76141734
47EWS_26573619_Chip-Seq_HEK293_Human1.75672217
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74947670
49ZFX_18555785_ChIP-Seq_MESCs_Mouse1.73205433
50FUS_26573619_Chip-Seq_HEK293_Human1.70973947
51CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.68440848
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.66049262
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.65299898
54TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64305501
55CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.64116834
56ELK1_19687146_ChIP-ChIP_HELA_Human1.63784225
57KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.63656632
58AR_21909140_ChIP-Seq_LNCAP_Human1.63182968
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.60897775
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.60631453
61MYCN_18555785_ChIP-Seq_MESCs_Mouse1.56273255
62EGR1_23403033_ChIP-Seq_LIVER_Mouse1.55502048
63HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.54908363
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.54018787
65CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.51424929
66ER_23166858_ChIP-Seq_MCF-7_Human1.51396537
67* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49147885
68BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.48605736
69RXR_22158963_ChIP-Seq_LIVER_Mouse1.48362405
70ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.46230812
71POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.45328533
72PPARA_22158963_ChIP-Seq_LIVER_Mouse1.41256664
73* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.40839258
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.35933034
75EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35557087
76PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33524916
77TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.32910435
78CIITA_25753668_ChIP-Seq_RAJI_Human1.31134059
79MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.28201673
80CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27291346
81* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24362187
82HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23636151
83FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.22267443
84MYC_18940864_ChIP-ChIP_HL60_Human1.20111301
85RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18561730
86MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18435037
87NANOG_18555785_ChIP-Seq_MESCs_Mouse1.17742851
88P300_19829295_ChIP-Seq_ESCs_Human1.17049006
89E2F1_21310950_ChIP-Seq_MCF-7_Human1.16580453
90PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13568484
91ELK1_22589737_ChIP-Seq_MCF10A_Human1.12656129
92* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12483774
93POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11763609
94* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11536442
95KDM5A_27292631_Chip-Seq_BREAST_Human1.11060366
96* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.10858650
97TAF15_26573619_Chip-Seq_HEK293_Human1.10274156
98PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09889484
99AR_21572438_ChIP-Seq_LNCaP_Human1.09821480
100* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08258384
101FOXM1_23109430_ChIP-Seq_U2OS_Human1.05130801
102SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05086341
103HOXB7_26014856_ChIP-Seq_BT474_Human1.04451875
104NFE2_27457419_Chip-Seq_LIVER_Mouse1.03733929
105TP53_22573176_ChIP-Seq_HFKS_Human1.03016407
106CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01554382
107ZFP57_27257070_Chip-Seq_ESCs_Mouse1.01538579
108SOX2_19829295_ChIP-Seq_ESCs_Human1.01479630
109NANOG_19829295_ChIP-Seq_ESCs_Human1.01479630
110DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.00198444
111AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00141156
112CBP_20019798_ChIP-Seq_JUKART_Human1.00130213
113IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.00130213
114EZH2_27294783_Chip-Seq_NPCs_Mouse0.98769936
115GATA1_22025678_ChIP-Seq_K562_Human0.96561767
116FOXA1_27270436_Chip-Seq_PROSTATE_Human0.95411685
117FOXA1_25329375_ChIP-Seq_VCAP_Human0.95411685
118CTCF_18555785_ChIP-Seq_MESCs_Mouse0.95196675
119E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95060701
120GBX2_23144817_ChIP-Seq_PC3_Human0.94549287
121CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91677070
122IRF1_19129219_ChIP-ChIP_H3396_Human0.89933438
123TBX5_21415370_ChIP-Seq_HL-1_Mouse0.89230808
124* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.89029036
125UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88372727
126KLF4_18555785_ChIP-Seq_MESCs_Mouse0.87879126
127SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.87045651
128SOX17_20123909_ChIP-Seq_XEN_Mouse0.87017818
129CDX2_22108803_ChIP-Seq_LS180_Human0.86566068
130FOXA1_21572438_ChIP-Seq_LNCaP_Human0.86363841
131HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.86261524
132AR_20517297_ChIP-Seq_VCAP_Human0.86132336
133NCOR_22424771_ChIP-Seq_293T_Human0.85331367
134TCF4_23295773_ChIP-Seq_U87_Human0.85269283
135KLF5_20875108_ChIP-Seq_MESCs_Mouse0.85144573
136STAT3_23295773_ChIP-Seq_U87_Human0.84988771
137* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84581933
138SOX2_18555785_ChIP-Seq_MESCs_Mouse0.80148501
139NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.79228289
140POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.77797450
141STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.77394988
142DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.75820698
143TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.71670299

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.55505298
2MP0003806_abnormal_nucleotide_metabolis3.78640631
3MP0009379_abnormal_foot_pigmentation3.72266860
4MP0005171_absent_coat_pigmentation3.39518889
5MP0002837_dystrophic_cardiac_calcinosis3.38320505
6MP0006036_abnormal_mitochondrial_physio3.34799637
7MP0005360_urolithiasis3.15657405
8MP0008057_abnormal_DNA_replication3.13167397
9MP0003646_muscle_fatigue3.00614396
10MP0004084_abnormal_cardiac_muscle3.00479667
11MP0002139_abnormal_hepatobiliary_system3.00296050
12MP0005085_abnormal_gallbladder_physiolo2.96429303
13MP0003693_abnormal_embryo_hatching2.86032697
14MP0003890_abnormal_embryonic-extraembry2.67071721
15MP0004957_abnormal_blastocyst_morpholog2.65959966
16MP0004215_abnormal_myocardial_fiber2.64898525
17MP0005365_abnormal_bile_salt2.59400285
18MP0009697_abnormal_copulation2.56995342
19MP0004147_increased_porphyrin_level2.45775367
20MP0003186_abnormal_redox_activity2.28561504
21MP0006035_abnormal_mitochondrial_morpho2.22246821
22MP0002938_white_spotting2.19044691
23MP0004036_abnormal_muscle_relaxation2.18706466
24MP0005330_cardiomyopathy2.14792986
25MP0000749_muscle_degeneration2.13604131
26MP0008875_abnormal_xenobiotic_pharmacok2.12112856
27MP0010094_abnormal_chromosome_stability2.10551530
28MP0002653_abnormal_ependyma_morphology2.02818908
29MP0005075_abnormal_melanosome_morpholog1.87409920
30MP0003077_abnormal_cell_cycle1.84409277
31MP0003221_abnormal_cardiomyocyte_apopto1.84379988
32MP0000569_abnormal_digit_pigmentation1.81862206
33MP0008058_abnormal_DNA_repair1.80594906
34MP0001764_abnormal_homeostasis1.78287595
35MP0002160_abnormal_reproductive_system1.77195919
36MP0010368_abnormal_lymphatic_system1.71979686
37MP0000751_myopathy1.68015728
38MP0008007_abnormal_cellular_replicative1.64673924
39MP0008877_abnormal_DNA_methylation1.63675074
40MP0003123_paternal_imprinting1.63337821
41MP0002163_abnormal_gland_morphology1.59902809
42MP0003111_abnormal_nucleus_morphology1.59610749
43MP0008775_abnormal_heart_ventricle1.55692835
44MP0002095_abnormal_skin_pigmentation1.55236214
45MP0003718_maternal_effect1.53769721
46MP0005332_abnormal_amino_acid1.50806397
47MP0004381_abnormal_hair_follicle1.50540388
48MP0003045_fibrosis1.48754901
49MP0005319_abnormal_enzyme/_coenzyme1.45683036
50MP0000427_abnormal_hair_cycle1.44950551
51MP0000372_irregular_coat_pigmentation1.43960152
52MP0006138_congestive_heart_failure1.43175047
53MP0002972_abnormal_cardiac_muscle1.42487298
54MP0003567_abnormal_fetal_cardiomyocyte1.41968082
55MP0003252_abnormal_bile_duct1.41426144
56MP0005385_cardiovascular_system_phenoty1.40023467
57MP0001544_abnormal_cardiovascular_syste1.40023467
58MP0005670_abnormal_white_adipose1.38085967
59MP0006072_abnormal_retinal_apoptosis1.37273350
60MP0003656_abnormal_erythrocyte_physiolo1.36807847
61MP0002138_abnormal_hepatobiliary_system1.34566339
62MP0008932_abnormal_embryonic_tissue1.34066378
63MP0005266_abnormal_metabolism1.31911982
64MP0002269_muscular_atrophy1.31656900
65MP0004043_abnormal_pH_regulation1.30506918
66MP0005395_other_phenotype1.30363314
67MP0002102_abnormal_ear_morphology1.26547853
68MP0000383_abnormal_hair_follicle1.24685286
69MP0000750_abnormal_muscle_regeneration1.24031609
70MP0008872_abnormal_physiological_respon1.22940737
71MP0002210_abnormal_sex_determination1.19646454
72MP0005379_endocrine/exocrine_gland_phen1.18691610
73MP0005084_abnormal_gallbladder_morpholo1.18469897
74MP0003137_abnormal_impulse_conducting1.17486348
75MP0001661_extended_life_span1.16890523
76MP0010329_abnormal_lipoprotein_level1.16378379
77MP0003828_pulmonary_edema1.16115361
78MP0003786_premature_aging1.15974768
79MP0005620_abnormal_muscle_contractility1.15590083
80MP0005174_abnormal_tail_pigmentation1.14510133
81MP0005636_abnormal_mineral_homeostasis1.14031086
82MP0005389_reproductive_system_phenotype1.13617020
83MP0005551_abnormal_eye_electrophysiolog1.13074035
84MP0004484_altered_response_of1.12377833
85MP0004087_abnormal_muscle_fiber1.09325461
86MP0010630_abnormal_cardiac_muscle1.08646153
87MP0005410_abnormal_fertilization1.07621952
88MP0004233_abnormal_muscle_weight1.06665208
89MP0002127_abnormal_cardiovascular_syste1.06396371
90MP0000015_abnormal_ear_pigmentation1.05677982
91MP0001730_embryonic_growth_arrest1.04811479
92MP0002396_abnormal_hematopoietic_system0.99089491
93MP0000358_abnormal_cell_content/0.97271755
94MP0001666_abnormal_nutrient_absorption0.96160158
95MP0003698_abnormal_male_reproductive0.95659426
96MP0001529_abnormal_vocalization0.95562710
97MP0001145_abnormal_male_reproductive0.95359864
98MP0005253_abnormal_eye_physiology0.94830602
99MP0000747_muscle_weakness0.94597730
100MP0005584_abnormal_enzyme/coenzyme_acti0.94559710
101MP0010678_abnormal_skin_adnexa0.94340977
102MP0002106_abnormal_muscle_physiology0.93424170
103MP0002075_abnormal_coat/hair_pigmentati0.91247710
104MP0000653_abnormal_sex_gland0.91242640
105MP0003195_calcinosis0.90894417
106MP0003937_abnormal_limbs/digits/tail_de0.89956184
107MP0009643_abnormal_urine_homeostasis0.89701864
108MP0003315_abnormal_perineum_morphology0.89154027
109MP0002928_abnormal_bile_duct0.88436104
110MP0005376_homeostasis/metabolism_phenot0.88221160
111MP0000647_abnormal_sebaceous_gland0.87030695
112MP0000598_abnormal_liver_morphology0.86669866
113MP0005220_abnormal_exocrine_pancreas0.86542399
114MP0000609_abnormal_liver_physiology0.86446551
115MP0005083_abnormal_biliary_tract0.85609149
116MP0005451_abnormal_body_composition0.84470748
117MP0003984_embryonic_growth_retardation0.84218887
118MP0002088_abnormal_embryonic_growth/wei0.84135271
119MP0001697_abnormal_embryo_size0.84015464
120MP0002876_abnormal_thyroid_physiology0.83989435
121MP0006054_spinal_hemorrhage0.83522183
122MP0002332_abnormal_exercise_endurance0.83325572
123MP0005408_hypopigmentation0.81202570
124MP0002234_abnormal_pharynx_morphology0.80945561
125MP0008995_early_reproductive_senescence0.80783441
126MP0003950_abnormal_plasma_membrane0.80022269
127MP0004019_abnormal_vitamin_homeostasis0.78725546
128MP0001853_heart_inflammation0.78561413
129MP0001879_abnormal_lymphatic_vessel0.78149416
130MP0001984_abnormal_olfaction0.77861631
131MP0001986_abnormal_taste_sensitivity0.77155935
132MP0004145_abnormal_muscle_electrophysio0.76312826
133MP0010352_gastrointestinal_tract_polyps0.76304927
134MP0002080_prenatal_lethality0.75605861
135MP0009840_abnormal_foam_cell0.75263908
136MP0003191_abnormal_cellular_cholesterol0.74083707
137MP0005380_embryogenesis_phenotype0.73613573
138MP0001672_abnormal_embryogenesis/_devel0.73613573
139MP0000759_abnormal_skeletal_muscle0.73285628
140MP0001186_pigmentation_phenotype0.73168137
141MP0001929_abnormal_gametogenesis0.73137550
142MP0002638_abnormal_pupillary_reflex0.72872692
143MP0001756_abnormal_urination0.71962797
144MP0002132_abnormal_respiratory_system0.71227470
145MP0002084_abnormal_developmental_patter0.70877319
146MP0001324_abnormal_eye_pigmentation0.69973119
147MP0010307_abnormal_tumor_latency0.69920527
148MP0004085_abnormal_heartbeat0.69453790
149MP0000371_diluted_coat_color0.69412291
150MP0002168_other_aberrant_phenotype0.69378218
151MP0001119_abnormal_female_reproductive0.68968075
152MP0002751_abnormal_autonomic_nervous0.68077879
153MP0005369_muscle_phenotype0.67937826
154MP0000490_abnormal_crypts_of0.66423615
155MP0000350_abnormal_cell_proliferation0.65785888
156MP0005645_abnormal_hypothalamus_physiol0.64852064
157MP0008789_abnormal_olfactory_epithelium0.64762871
158MP0003943_abnormal_hepatobiliary_system0.64582064
159MP0005646_abnormal_pituitary_gland0.63428533
160MP0006292_abnormal_olfactory_placode0.62875546

Predicted human phenotypes

RankGene SetZ-score
1Hepatic necrosis (HP:0002605)5.16920961
2Hepatocellular necrosis (HP:0001404)5.07044508
3Acute necrotizing encephalopathy (HP:0006965)4.90467407
4Abnormal mitochondria in muscle tissue (HP:0008316)4.81514668
5Mitochondrial inheritance (HP:0001427)4.72421978
6Acute encephalopathy (HP:0006846)4.60598083
7Increased CSF lactate (HP:0002490)4.51018425
8Decreased activity of mitochondrial respiratory chain (HP:0008972)4.22787406
9Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.22787406
10Progressive macrocephaly (HP:0004481)3.99404175
11Cerebral edema (HP:0002181)3.99119858
12Chromosomal breakage induced by crosslinking agents (HP:0003221)3.91472770
13Increased serum lactate (HP:0002151)3.89509770
14Chromsome breakage (HP:0040012)3.88547897
15Abnormality of glycolysis (HP:0004366)3.86954313
16Increased serum pyruvate (HP:0003542)3.86954313
17Lactic acidosis (HP:0003128)3.80987031
18Increased intramyocellular lipid droplets (HP:0012240)3.75962186
19Increased muscle lipid content (HP:0009058)3.74263990
20Aplasia/Hypoplasia of the uvula (HP:0010293)3.63329791
21Lipid accumulation in hepatocytes (HP:0006561)3.61106352
22Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.60812745
23Abnormality of cells of the erythroid lineage (HP:0012130)3.51991309
24Abnormal number of erythroid precursors (HP:0012131)3.48554486
25Increased hepatocellular lipid droplets (HP:0006565)3.41148032
26Pancreatic cysts (HP:0001737)3.34425421
27Reticulocytopenia (HP:0001896)3.29584978
28Exercise intolerance (HP:0003546)3.26175362
29Dicarboxylic aciduria (HP:0003215)3.19131588
30Abnormality of dicarboxylic acid metabolism (HP:0010995)3.19131588
31Respiratory failure (HP:0002878)3.15329724
32Ragged-red muscle fibers (HP:0003200)3.14334789
33Amelogenesis imperfecta (HP:0000705)3.10762343
34Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.09222148
35Hyperammonemia (HP:0001987)3.04001576
36Abnormality of aromatic amino acid family metabolism (HP:0004338)2.99844680
37Lethargy (HP:0001254)2.98858450
38Abnormality of fatty-acid metabolism (HP:0004359)2.92391317
39Rhabdomyolysis (HP:0003201)2.91147945
40Hyperglycinemia (HP:0002154)2.90694589
41Abnormality of the renal cortex (HP:0011035)2.84509802
42Hypoglycemic coma (HP:0001325)2.84317190
43Aplastic anemia (HP:0001915)2.81528903
443-Methylglutaconic aciduria (HP:0003535)2.79293751
45Generalized aminoaciduria (HP:0002909)2.78989083
46Hypobetalipoproteinemia (HP:0003563)2.78265139
47Myoglobinuria (HP:0002913)2.77912032
48Abnormality of alanine metabolism (HP:0010916)2.75610809
49Hyperalaninemia (HP:0003348)2.75610809
50Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.75610809
51Abnormality of the preputium (HP:0100587)2.74913575
52Renal Fanconi syndrome (HP:0001994)2.73577378
53CNS demyelination (HP:0007305)2.67961246
54Nephronophthisis (HP:0000090)2.67017352
55Palpitations (HP:0001962)2.65142610
56Macrocytic anemia (HP:0001972)2.65065647
57Birth length less than 3rd percentile (HP:0003561)2.58171566
58Abnormality of chromosome stability (HP:0003220)2.58098659
59Meckel diverticulum (HP:0002245)2.55668930
60Type I transferrin isoform profile (HP:0003642)2.54621403
61Pancreatic fibrosis (HP:0100732)2.54603211
62Abnormality of urine glucose concentration (HP:0011016)2.53790526
63Glycosuria (HP:0003076)2.53790526
64Abnormality of the ileum (HP:0001549)2.53705467
65Nausea (HP:0002018)2.53670283
66Hyperglycinuria (HP:0003108)2.53105561
67Hypoplasia of the pons (HP:0012110)2.52983695
68Oral leukoplakia (HP:0002745)2.51574847
69Abnormality of serum amino acid levels (HP:0003112)2.51215609
70Abnormality of the pons (HP:0007361)2.51084022
71Abnormality of the renal medulla (HP:0100957)2.50898822
72Abnormality of serine family amino acid metabolism (HP:0010894)2.43907422
73Abnormality of glycine metabolism (HP:0010895)2.43907422
74Ketosis (HP:0001946)2.41544153
75Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.41406407
76Intrahepatic cholestasis (HP:0001406)2.40124490
77Exertional dyspnea (HP:0002875)2.39251138
78Ventricular tachycardia (HP:0004756)2.39165096
79Abnormality of monocarboxylic acid metabolism (HP:0010996)2.38901407
80Respiratory difficulties (HP:0002880)2.37076616
81Cerebellar dysplasia (HP:0007033)2.36234849
82Microvesicular hepatic steatosis (HP:0001414)2.36232432
83Emotional lability (HP:0000712)2.35868069
84Lipoatrophy (HP:0100578)2.34210880
85Metabolic acidosis (HP:0001942)2.33789065
86Multiple enchondromatosis (HP:0005701)2.33356488
87Pallor (HP:0000980)2.28917237
88Sudden death (HP:0001699)2.26379650
89Proximal tubulopathy (HP:0000114)2.24227150
90Methylmalonic aciduria (HP:0012120)2.24044263
91Abnormality of midbrain morphology (HP:0002418)2.23742384
92Molar tooth sign on MRI (HP:0002419)2.23742384
93Duplicated collecting system (HP:0000081)2.21811914
94Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.18826908
95Sloping forehead (HP:0000340)2.16360571
96Abnormality of pyrimidine metabolism (HP:0004353)2.16191945
97Volvulus (HP:0002580)2.14987898
98Calf muscle hypertrophy (HP:0008981)2.14452371
99Abnormality of the heme biosynthetic pathway (HP:0010472)2.14123989
100Pendular nystagmus (HP:0012043)2.13951603
101Abnormality of the renal collecting system (HP:0004742)2.12644075
102Tubular atrophy (HP:0000092)2.12588772
103Prolonged partial thromboplastin time (HP:0003645)2.12029251
104Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.11225390
105Abnormal protein N-linked glycosylation (HP:0012347)2.11225390
106Abnormal protein glycosylation (HP:0012346)2.11225390
107Abnormal glycosylation (HP:0012345)2.11225390
108Dilated cardiomyopathy (HP:0001644)2.11022838
109Leukodystrophy (HP:0002415)2.09995671
110Methylmalonic acidemia (HP:0002912)2.09365046
111Clubbing of toes (HP:0100760)2.08426260
112Type II lissencephaly (HP:0007260)2.07718816
113Abnormal hemoglobin (HP:0011902)2.06611345
114Small intestinal stenosis (HP:0012848)2.06448827
115Duodenal stenosis (HP:0100867)2.06448827
116Renal cortical cysts (HP:0000803)2.03937293
117Vomiting (HP:0002013)2.03363655
118Chronic hepatic failure (HP:0100626)2.03252189
119True hermaphroditism (HP:0010459)2.02146162
120Supraventricular tachycardia (HP:0004755)2.00635794
121Optic disc pallor (HP:0000543)2.00366352
122Progressive external ophthalmoplegia (HP:0000590)2.00034238
123Ketoacidosis (HP:0001993)1.99010983
124Colon cancer (HP:0003003)1.96344596
125Gliosis (HP:0002171)1.95322295
126Atrial fibrillation (HP:0005110)1.95252532
127Progressive muscle weakness (HP:0003323)1.94680199
128Pancytopenia (HP:0001876)1.94576347
129Supraventricular arrhythmia (HP:0005115)1.93146264
130Thrombocytosis (HP:0001894)1.93015384
131Abnormality of DNA repair (HP:0003254)1.92940683
132Cystic liver disease (HP:0006706)1.92913831
133Abnormality of methionine metabolism (HP:0010901)1.92596703
134Muscle hypertrophy of the lower extremities (HP:0008968)1.92358694
135Degeneration of anterior horn cells (HP:0002398)1.91727493
136Abnormality of the anterior horn cell (HP:0006802)1.91727493
137Microretrognathia (HP:0000308)1.91017775
138Exercise-induced muscle cramps (HP:0003710)1.90653961
139Abnormality of the labia minora (HP:0012880)1.90080422
140Abnormality of aspartate family amino acid metabolism (HP:0010899)1.89245806
141Hyperphosphaturia (HP:0003109)1.86892497
142Tubulointerstitial nephritis (HP:0001970)1.85921170
143Hypolipoproteinemia (HP:0010981)1.85631681
144Enlarged kidneys (HP:0000105)1.85073664
145Medial flaring of the eyebrow (HP:0010747)1.83781939
146Absent thumb (HP:0009777)1.82837025
147Aplasia/Hypoplasia of the tibia (HP:0005772)1.81084681
148Acanthocytosis (HP:0001927)1.78995985
149Abnormality of the duodenum (HP:0002246)1.78871042
150Attenuation of retinal blood vessels (HP:0007843)1.76990905
151Hyperinsulinemic hypoglycemia (HP:0000825)1.76950845
152Polydipsia (HP:0001959)1.74637298
153Abnormal drinking behavior (HP:0030082)1.74637298
154Neoplasm of the adrenal cortex (HP:0100641)1.73558996
155Ectopic kidney (HP:0000086)1.73060297
156Parakeratosis (HP:0001036)1.73054810
157Myelodysplasia (HP:0002863)1.72030919
158Constricted visual fields (HP:0001133)1.69462315
159Abnormality of the carotid arteries (HP:0005344)1.68885261
160Neoplasm of the adrenal gland (HP:0100631)1.68809671
161Abnormality of sulfur amino acid metabolism (HP:0004339)1.67990668
162Triphalangeal thumb (HP:0001199)1.65388116

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS15.15275032
2EIF2AK14.33067947
3BUB14.09527441
4FRK3.82190636
5STK163.62642593
6NME23.48498963
7BCKDK3.47863757
8WEE12.64611107
9MST42.64194694
10PDK32.47204244
11PDK42.47204244
12MYLK2.46654621
13BRSK22.20350338
14VRK12.03289526
15MAP4K22.00514564
16TLK12.00128814
17VRK21.99371840
18EIF2AK31.98110831
19LATS21.96046025
20TSSK61.95293576
21KDR1.94536307
22WNK41.90396037
23OBSCN1.90136367
24STK391.88317523
25NME11.86328580
26STK31.80867556
27NEK11.76507648
28TIE11.73825031
29MAP2K31.71752925
30ZAK1.65284470
31FLT31.60833469
32CDC71.60120209
33MKNK11.54876542
34MAP3K111.47899698
35OXSR11.45553061
36TGFBR11.40329904
37TRIM281.36255341
38CDK81.33949355
39CCNB11.30079226
40ACVR1B1.26140660
41PIM21.25987703
42DYRK31.22731767
43TTK1.22256144
44SRPK11.21882033
45TAF11.21466783
46PDK21.18756738
47ILK1.18469381
48MAP2K61.16815943
49AURKB1.13395884
50PLK11.13354841
51PKN21.12527298
52BRAF1.08638176
53MELK1.05407646
54BRSK11.05283309
55MUSK1.03956026
56AURKA1.03401763
57WNK30.97960381
58NEK20.96607261
59PINK10.96292514
60PLK40.94501546
61MST1R0.94151963
62STK38L0.93569598
63PASK0.93351482
64TAOK20.90222435
65GRK10.89973864
66ABL20.88335809
67MKNK20.88271022
68CDK70.86105282
69MAP3K30.85735741
70TAOK30.82704631
71PNCK0.82539256
72ADRBK20.80978266
73PRKD30.80829001
74PLK30.80772169
75EIF2AK20.79694707
76MAP2K20.79025644
77PAK40.78231534
78MAP3K50.77674904
79CSNK2A10.76313773
80RPS6KA40.75603849
81STK240.73413831
82AKT30.72398489
83CSNK2A20.70889200
84CSNK1A1L0.70620554
85MAP3K120.70108674
86LIMK10.69952852
87ATR0.68414440
88PRKAA20.68379677
89NEK90.66361011
90TNIK0.65797643
91TTN0.65193550
92MAPKAPK50.64968941
93LMTK20.63934130
94CHEK20.63813527
95TEC0.61404930
96ERBB30.60490752
97TESK10.59809709
98PIK3CG0.56764163
99RPS6KB20.54953394
100NUAK10.52043834
101CDK30.51703031
102DYRK20.50144441
103MET0.48953087
104MAP2K70.47021511
105STK40.46933436
106MAP4K10.46001234
107MAPKAPK30.44930416
108CAMK1G0.44682667
109TESK20.43499663
110PBK0.42569467
111STK380.42278952
112TRPM70.42093561
113DAPK30.40820173
114NEK60.39092854
115CDK40.38395738
116MAP3K80.36876696
117ADRBK10.35226145
118PAK10.34735804
119CSNK1G10.34646401
120ARAF0.34375272
121PIM10.32588038
122PRKCI0.30857011
123ERBB40.30102215
124PIK3CA0.28040731
125BMPR1B0.27745354
126MAPK40.27647098
127RPS6KA50.27534498
128PHKG20.27507855
129PHKG10.27507855
130CHEK10.27049578
131CAMK1D0.26994626
132MARK30.25981149
133MAP3K40.25850064
134MAP3K60.25666469
135NLK0.25464740
136ATM0.25191640
137CDK10.25057780
138CSNK1G30.24784281
139INSRR0.24455290
140MAP2K10.23984252
141PLK20.23798463
142MAP2K40.23005292
143SCYL20.22689237
144GRK70.22662064
145STK100.22480025
146DAPK10.22337574

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.62149437
2Proteasome_Homo sapiens_hsa030503.27848523
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.12132830
4Oxidative phosphorylation_Homo sapiens_hsa001902.89886486
5Parkinsons disease_Homo sapiens_hsa050122.79081987
6RNA polymerase_Homo sapiens_hsa030202.70042551
7DNA replication_Homo sapiens_hsa030302.62124470
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.21311851
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.20922870
10Propanoate metabolism_Homo sapiens_hsa006402.20357869
11Pyrimidine metabolism_Homo sapiens_hsa002402.17113736
12Mismatch repair_Homo sapiens_hsa034302.11904957
13Huntingtons disease_Homo sapiens_hsa050162.11168682
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.10312065
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.95425709
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.92938547
17Carbon metabolism_Homo sapiens_hsa012001.85953676
18Pyruvate metabolism_Homo sapiens_hsa006201.85074381
19Fatty acid degradation_Homo sapiens_hsa000711.80476085
20Phototransduction_Homo sapiens_hsa047441.73035512
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.70914480
22Nucleotide excision repair_Homo sapiens_hsa034201.68229652
23Alzheimers disease_Homo sapiens_hsa050101.67128194
24Folate biosynthesis_Homo sapiens_hsa007901.66183893
25One carbon pool by folate_Homo sapiens_hsa006701.65814441
26Protein export_Homo sapiens_hsa030601.65652834
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.62690069
28Base excision repair_Homo sapiens_hsa034101.59032652
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.58894004
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.57105435
31Spliceosome_Homo sapiens_hsa030401.56877419
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.55603411
33RNA transport_Homo sapiens_hsa030131.53797321
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.46705287
35Primary bile acid biosynthesis_Homo sapiens_hsa001201.46389861
36Homologous recombination_Homo sapiens_hsa034401.45814589
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.44387367
38Biosynthesis of amino acids_Homo sapiens_hsa012301.44214221
39Sulfur relay system_Homo sapiens_hsa041221.36665821
40Drug metabolism - other enzymes_Homo sapiens_hsa009831.35977181
41Butanoate metabolism_Homo sapiens_hsa006501.31949491
42Cardiac muscle contraction_Homo sapiens_hsa042601.29725374
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.27114494
44Purine metabolism_Homo sapiens_hsa002301.23821395
45Tryptophan metabolism_Homo sapiens_hsa003801.23663039
46Selenocompound metabolism_Homo sapiens_hsa004501.20210182
47RNA degradation_Homo sapiens_hsa030181.18345467
48Peroxisome_Homo sapiens_hsa041461.17656524
49Fatty acid elongation_Homo sapiens_hsa000621.15206126
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.11395576
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.09796332
52Basal transcription factors_Homo sapiens_hsa030221.06658752
53Fatty acid metabolism_Homo sapiens_hsa012121.05119195
54Glutathione metabolism_Homo sapiens_hsa004801.04590878
55Cyanoamino acid metabolism_Homo sapiens_hsa004601.02795683
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02644715
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.02130672
58beta-Alanine metabolism_Homo sapiens_hsa004100.99473252
59Cell cycle_Homo sapiens_hsa041100.97599242
60Pentose phosphate pathway_Homo sapiens_hsa000300.97138463
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.94735079
62Sphingolipid metabolism_Homo sapiens_hsa006000.86958657
63Metabolic pathways_Homo sapiens_hsa011000.86411555
64Phenylalanine metabolism_Homo sapiens_hsa003600.83056434
65Nitrogen metabolism_Homo sapiens_hsa009100.82520996
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81210293
67Arginine biosynthesis_Homo sapiens_hsa002200.81099335
68Tyrosine metabolism_Homo sapiens_hsa003500.80727451
69Arginine and proline metabolism_Homo sapiens_hsa003300.78075646
70Linoleic acid metabolism_Homo sapiens_hsa005910.78068586
71ABC transporters_Homo sapiens_hsa020100.77630134
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76584813
73Fanconi anemia pathway_Homo sapiens_hsa034600.75219778
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.71593684
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69216958
76Chemical carcinogenesis_Homo sapiens_hsa052040.68748156
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67739866
78Lysine degradation_Homo sapiens_hsa003100.64646670
79Vitamin B6 metabolism_Homo sapiens_hsa007500.64294624
80Non-homologous end-joining_Homo sapiens_hsa034500.62830970
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62522120
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61187201
83Caffeine metabolism_Homo sapiens_hsa002320.61119677
84PPAR signaling pathway_Homo sapiens_hsa033200.59902106
85Fructose and mannose metabolism_Homo sapiens_hsa000510.59784378
86Taste transduction_Homo sapiens_hsa047420.59588428
87Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59503475
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57900022
89Galactose metabolism_Homo sapiens_hsa000520.54360270
90Complement and coagulation cascades_Homo sapiens_hsa046100.54296280
91Olfactory transduction_Homo sapiens_hsa047400.54135571
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52756782
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52319066
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51981046
95Histidine metabolism_Homo sapiens_hsa003400.51507479
96Oocyte meiosis_Homo sapiens_hsa041140.48082227
97Starch and sucrose metabolism_Homo sapiens_hsa005000.43824258
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43405136
99Epstein-Barr virus infection_Homo sapiens_hsa051690.42414753
100Collecting duct acid secretion_Homo sapiens_hsa049660.41050344
101Retinol metabolism_Homo sapiens_hsa008300.40446859
102Sulfur metabolism_Homo sapiens_hsa009200.40417899
103Fat digestion and absorption_Homo sapiens_hsa049750.38927230
104p53 signaling pathway_Homo sapiens_hsa041150.38638394
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37715612
106Regulation of autophagy_Homo sapiens_hsa041400.36141692
107mRNA surveillance pathway_Homo sapiens_hsa030150.32715494
108Systemic lupus erythematosus_Homo sapiens_hsa053220.23473119
109Steroid hormone biosynthesis_Homo sapiens_hsa001400.22859157
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.19343173
111Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.17855342
112Arachidonic acid metabolism_Homo sapiens_hsa005900.17826273
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.16327981
114Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.14956355
115Legionellosis_Homo sapiens_hsa051340.12468152
116Vitamin digestion and absorption_Homo sapiens_hsa049770.11503512
117N-Glycan biosynthesis_Homo sapiens_hsa005100.10795841
118Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.10043881

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