MRRFP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.85464614
2mitochondrion transport along microtubule (GO:0047497)5.89241025
3establishment of mitochondrion localization, microtubule-mediated (GO:0034643)5.89241025
4sulfur amino acid catabolic process (GO:0000098)5.81659836
5cellular modified amino acid catabolic process (GO:0042219)5.56645405
6rRNA catabolic process (GO:0016075)5.41128232
7somatic hypermutation of immunoglobulin genes (GO:0016446)5.30152572
8somatic diversification of immune receptors via somatic mutation (GO:0002566)5.30152572
9establishment of mitochondrion localization (GO:0051654)5.19124747
10mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)5.15050816
11positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021105.15050816
12base-excision repair, AP site formation (GO:0006285)5.06341149
13purine nucleobase biosynthetic process (GO:0009113)4.88444856
14myelin assembly (GO:0032288)4.79588454
15blood vessel maturation (GO:0001955)4.74319244
16prenylation (GO:0097354)4.57189610
17protein prenylation (GO:0018342)4.57189610
18nucleobase biosynthetic process (GO:0046112)4.32051202
19pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.28937909
20pyrimidine nucleotide catabolic process (GO:0006244)4.22588574
21GMP metabolic process (GO:0046037)4.15400956
22histone H3-K9 methylation (GO:0051567)4.12076867
23cilium or flagellum-dependent cell motility (GO:0001539)3.97809773
24positive regulation of guanylate cyclase activity (GO:0031284)3.87519396
25regulation of telomere maintenance via telomerase (GO:0032210)3.71222637
26negative regulation of telomere maintenance (GO:0032205)3.63323428
27protein K11-linked ubiquitination (GO:0070979)3.62897687
28pyrimidine ribonucleoside catabolic process (GO:0046133)3.57844608
29kynurenine metabolic process (GO:0070189)3.56761189
30cytidine deamination (GO:0009972)3.56294687
31cytidine metabolic process (GO:0046087)3.56294687
32cytidine catabolic process (GO:0006216)3.56294687
33ribonucleoprotein complex disassembly (GO:0032988)3.54362866
34spliceosomal tri-snRNP complex assembly (GO:0000244)3.54036635
35negative regulation of DNA biosynthetic process (GO:2000279)3.53675152
36ncRNA catabolic process (GO:0034661)3.52793326
37exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.52510976
38nucleoside transmembrane transport (GO:1901642)3.50624508
39regulation of guanylate cyclase activity (GO:0031282)3.49060401
40spliceosomal snRNP assembly (GO:0000387)3.48759134
41L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.48172252
42histone H3-K9 modification (GO:0061647)3.46254264
43epithelial cell maturation (GO:0002070)3.42113462
44neuron cell-cell adhesion (GO:0007158)3.41953684
45positive regulation of mitochondrial membrane permeability (GO:0035794)3.41759255
46mitochondrial RNA metabolic process (GO:0000959)3.41260395
47regulation of nuclear cell cycle DNA replication (GO:0033262)3.36989896
48mitochondrial respiratory chain complex I assembly (GO:0032981)3.32747005
49NADH dehydrogenase complex assembly (GO:0010257)3.32747005
50mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.32747005
51cellular response to ATP (GO:0071318)3.32050475
52histone H3-K4 methylation (GO:0051568)3.31065705
53piRNA metabolic process (GO:0034587)3.29562357
54nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.29340752
55hair cell differentiation (GO:0035315)3.24739664
56ER overload response (GO:0006983)3.24140021
57rRNA modification (GO:0000154)3.21660651
58embryonic camera-type eye development (GO:0031076)3.17707623
59DNA demethylation (GO:0080111)3.17382864
60macroautophagy (GO:0016236)3.17167822
61regulation of double-strand break repair via homologous recombination (GO:0010569)3.15092591
62epithelial cilium movement (GO:0003351)3.13282708
63positive regulation of prostaglandin secretion (GO:0032308)3.12262447
64calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.05097009
65regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)3.04715322
66mitochondrial respiratory chain complex assembly (GO:0033108)2.99990034
67DNA dealkylation (GO:0035510)2.99105460
68regulation of rhodopsin mediated signaling pathway (GO:0022400)2.97519799
69L-methionine salvage (GO:0071267)2.93772813
70L-methionine biosynthetic process (GO:0071265)2.93772813
71amino acid salvage (GO:0043102)2.93772813
72DNA modification (GO:0006304)2.93323771
73barbed-end actin filament capping (GO:0051016)2.92739938
74tRNA processing (GO:0008033)2.89414764
75rRNA methylation (GO:0031167)2.87712077
76positive regulation of mitochondrial fission (GO:0090141)2.87698729
77heterochromatin organization (GO:0070828)2.86139934
78protein neddylation (GO:0045116)2.85912971
79protein complex biogenesis (GO:0070271)2.79782464
80organelle disassembly (GO:1903008)2.79700908
81rhodopsin mediated signaling pathway (GO:0016056)2.77444357
82erythrocyte maturation (GO:0043249)2.76065181
83DNA double-strand break processing (GO:0000729)2.74925764
84cellular respiration (GO:0045333)2.74550548
85release of sequestered calcium ion into cytosol (GO:0051209)2.74187839
86negative regulation of sequestering of calcium ion (GO:0051283)2.74187839
87histone lysine methylation (GO:0034968)2.72199622
88cullin deneddylation (GO:0010388)2.71602943
89DNA deamination (GO:0045006)2.71375994
90regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.71104039
91protein-cofactor linkage (GO:0018065)2.68782023
92protein deneddylation (GO:0000338)2.67946682
93DNA methylation or demethylation (GO:0044728)2.65927042
94pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.63518841
95negative regulation of cAMP-mediated signaling (GO:0043951)2.61543054
96negative regulation of telomerase activity (GO:0051974)2.61314531
97regulation of protein kinase A signaling (GO:0010738)2.58161874
98aspartate family amino acid biosynthetic process (GO:0009067)2.56726959
99peptidyl-lysine trimethylation (GO:0018023)2.55402297
100transcription from mitochondrial promoter (GO:0006390)2.54180786

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human4.36917011
2HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.82433425
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.50511608
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.46486185
5CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.16744899
6ZNF274_21170338_ChIP-Seq_K562_Hela3.16270169
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.15341565
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.07495467
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.98886971
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.96857256
11CIITA_25753668_ChIP-Seq_RAJI_Human2.86915954
12VDR_23849224_ChIP-Seq_CD4+_Human2.81753923
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.72179015
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.50659507
15THAP11_20581084_ChIP-Seq_MESCs_Mouse2.49557837
16GATA1_26923725_Chip-Seq_HPCs_Mouse2.39163361
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.36193958
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.31479681
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.18628517
20IRF1_19129219_ChIP-ChIP_H3396_Human2.07116884
21FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.05011303
22FOXP3_21729870_ChIP-Seq_TREG_Human2.01707020
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.00492432
24NOTCH1_21737748_ChIP-Seq_TLL_Human1.89385811
25CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.87057291
26GABP_19822575_ChIP-Seq_HepG2_Human1.82073838
27KDM5A_27292631_Chip-Seq_BREAST_Human1.79916175
28DCP1A_22483619_ChIP-Seq_HELA_Human1.79008781
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.77027670
30ETV2_25802403_ChIP-Seq_MESCs_Mouse1.76020777
31E2F4_17652178_ChIP-ChIP_JURKAT_Human1.72325273
32MYC_18940864_ChIP-ChIP_HL60_Human1.64552304
33EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.63363907
34PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.61512594
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.59322176
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.59282330
37MYC_18555785_ChIP-Seq_MESCs_Mouse1.55892129
38HTT_18923047_ChIP-ChIP_STHdh_Human1.48195301
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.44527460
40CBP_21632823_ChIP-Seq_H3396_Human1.43303867
41ESR1_15608294_ChIP-ChIP_MCF-7_Human1.42112133
42MYC_18358816_ChIP-ChIP_MESCs_Mouse1.40297731
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.39839626
44GBX2_23144817_ChIP-Seq_PC3_Human1.38281944
45TTF2_22483619_ChIP-Seq_HELA_Human1.34038569
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33590724
47TP53_22573176_ChIP-Seq_HFKS_Human1.31349996
48XRN2_22483619_ChIP-Seq_HELA_Human1.30430512
49MYC_19030024_ChIP-ChIP_MESCs_Mouse1.28630572
50ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.28260155
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27560447
52CBP_20019798_ChIP-Seq_JUKART_Human1.25492973
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25492973
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24150824
55CREB1_15753290_ChIP-ChIP_HEK293T_Human1.23776060
56RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.22906726
57PHF8_20622854_ChIP-Seq_HELA_Human1.21911575
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.21194947
59HOXB7_26014856_ChIP-Seq_BT474_Human1.20680936
60ZNF263_19887448_ChIP-Seq_K562_Human1.17664326
61HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.16141559
62E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14496664
63ELK1_19687146_ChIP-ChIP_HELA_Human1.14472083
64EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11975671
65GATA3_26560356_Chip-Seq_TH2_Human1.10567362
66GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.09655197
67EZH2_22144423_ChIP-Seq_EOC_Human1.09569041
68PHF8_20622853_ChIP-Seq_HELA_Human1.09013809
69CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.08720574
70EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.05453306
71TBL1_22424771_ChIP-Seq_293T_Human1.05145275
72GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.04843506
73EGR1_23403033_ChIP-Seq_LIVER_Mouse1.03277586
74RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02998854
75LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.01653881
76PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01456594
77RAC3_21632823_ChIP-Seq_H3396_Human1.01014227
78ERA_21632823_ChIP-Seq_H3396_Human0.99515338
79GATA3_21878914_ChIP-Seq_MCF-7_Human0.99120326
80YY1_21170310_ChIP-Seq_MESCs_Mouse0.98992749
81CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98034767
82ELF1_20517297_ChIP-Seq_JURKAT_Human0.97906188
83EWS_26573619_Chip-Seq_HEK293_Human0.97245730
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96224146
85ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94297629
86NFYB_21822215_ChIP-Seq_K562_Human0.94283553
87YY1_22570637_ChIP-Seq_MALME-3M_Human0.94184807
88NANOG_20526341_ChIP-Seq_ESCs_Human0.91859229
89CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.91659790
90NFYA_21822215_ChIP-Seq_K562_Human0.91413318
91POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.90514413
92STAT1_20625510_ChIP-Seq_HELA_Human0.90447044
93E2F1_18555785_ChIP-Seq_MESCs_Mouse0.90293615
94TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.90246464
95TAL1_26923725_Chip-Seq_HPCs_Mouse0.89765940
96PADI4_21655091_ChIP-ChIP_MCF-7_Human0.89574676
97SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.88828819
98PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.88488008
99FOXA1_27270436_Chip-Seq_PROSTATE_Human0.87968056
100FOXA1_25329375_ChIP-Seq_VCAP_Human0.87968056

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004133_heterotaxia5.63243213
2MP0002837_dystrophic_cardiac_calcinosis3.96967908
3MP0003656_abnormal_erythrocyte_physiolo3.49305981
4MP0003880_abnormal_central_pattern3.44381731
5MP0002938_white_spotting3.38836321
6MP0008877_abnormal_DNA_methylation3.26450901
7MP0002909_abnormal_adrenal_gland2.80258019
8MP0000013_abnormal_adipose_tissue2.77832920
9MP0008058_abnormal_DNA_repair2.71636300
10MP0000569_abnormal_digit_pigmentation2.61770452
11MP0003878_abnormal_ear_physiology2.61766557
12MP0005377_hearing/vestibular/ear_phenot2.61766557
13MP0002653_abnormal_ependyma_morphology2.45905061
14MP0003195_calcinosis2.43408000
15MP0001485_abnormal_pinna_reflex2.41047845
16MP0000383_abnormal_hair_follicle2.38817204
17MP0004147_increased_porphyrin_level2.37718347
18MP0003787_abnormal_imprinting2.32390677
19MP0000015_abnormal_ear_pigmentation2.21112637
20MP0004885_abnormal_endolymph2.10214427
21MP0008057_abnormal_DNA_replication2.05593852
22MP0002102_abnormal_ear_morphology2.02365305
23MP0008775_abnormal_heart_ventricle1.90523993
24MP0003806_abnormal_nucleotide_metabolis1.84554140
25MP0003693_abnormal_embryo_hatching1.72369462
26MP0005084_abnormal_gallbladder_morpholo1.70087697
27MP0008872_abnormal_physiological_respon1.69465053
28MP0003941_abnormal_skin_development1.60096969
29MP0002138_abnormal_hepatobiliary_system1.52997845
30MP0003646_muscle_fatigue1.51256587
31MP0006276_abnormal_autonomic_nervous1.48858820
32MP0004043_abnormal_pH_regulation1.47328340
33MP0002277_abnormal_respiratory_mucosa1.38575393
34MP0006036_abnormal_mitochondrial_physio1.37912564
35MP0010678_abnormal_skin_adnexa1.36075851
36MP0005551_abnormal_eye_electrophysiolog1.27373710
37MP0000230_abnormal_systemic_arterial1.23518224
38MP0005075_abnormal_melanosome_morpholog1.17127258
39MP0002095_abnormal_skin_pigmentation1.16867324
40MP0008932_abnormal_embryonic_tissue1.12888666
41MP0002272_abnormal_nervous_system1.08603924
42MP0004859_abnormal_synaptic_plasticity1.08310497
43MP0000003_abnormal_adipose_tissue1.07201017
44MP0000749_muscle_degeneration1.03563972
45MP0009046_muscle_twitch1.01509138
46MP0004215_abnormal_myocardial_fiber1.01274665
47MP0001968_abnormal_touch/_nociception0.98501668
48MP0005423_abnormal_somatic_nervous0.96384314
49MP0003136_yellow_coat_color0.95983641
50MP0008875_abnormal_xenobiotic_pharmacok0.93816597
51MP0001188_hyperpigmentation0.87413727
52MP0005360_urolithiasis0.86359458
53MP0004084_abnormal_cardiac_muscle0.85977162
54MP0006072_abnormal_retinal_apoptosis0.84757405
55MP0003786_premature_aging0.84716003
56MP0005332_abnormal_amino_acid0.82160898
57MP0000470_abnormal_stomach_morphology0.81068081
58MP0005266_abnormal_metabolism0.80476090
59MP0004957_abnormal_blastocyst_morpholog0.79319574
60MP0001440_abnormal_grooming_behavior0.78362558
61MP0000358_abnormal_cell_content/0.77911114
62MP0010030_abnormal_orbit_morphology0.75077250
63MP0004742_abnormal_vestibular_system0.73312260
64MP0008569_lethality_at_weaning0.73193355
65MP0004142_abnormal_muscle_tone0.72678997
66MP0004924_abnormal_behavior0.71285575
67MP0005386_behavior/neurological_phenoty0.71285575
68MP0002751_abnormal_autonomic_nervous0.69360988
69MP0001661_extended_life_span0.68314962
70MP0001324_abnormal_eye_pigmentation0.68181091
71MP0005671_abnormal_response_to0.67728152
72MP0000631_abnormal_neuroendocrine_gland0.67573973
73MP0002063_abnormal_learning/memory/cond0.63442772
74MP0001764_abnormal_homeostasis0.62894067
75MP0002084_abnormal_developmental_patter0.61900014
76MP0001986_abnormal_taste_sensitivity0.61369888
77MP0002405_respiratory_system_inflammati0.60934854
78MP0002229_neurodegeneration0.60854619
79MP0005376_homeostasis/metabolism_phenot0.60783462
80MP0000372_irregular_coat_pigmentation0.59619188
81MP0005410_abnormal_fertilization0.59450402
82MP0002168_other_aberrant_phenotype0.59317983
83MP0005645_abnormal_hypothalamus_physiol0.58469146
84MP0009745_abnormal_behavioral_response0.56480723
85MP0005636_abnormal_mineral_homeostasis0.55278399
86MP0001756_abnormal_urination0.55097231
87MP0003718_maternal_effect0.55074512
88MP0002572_abnormal_emotion/affect_behav0.54246043
89MP0001873_stomach_inflammation0.53963097
90MP0004145_abnormal_muscle_electrophysio0.53741253
91MP0002089_abnormal_postnatal_growth/wei0.53533906
92MP0002067_abnormal_sensory_capabilities0.53089421
93MP0002254_reproductive_system_inflammat0.53015398
94MP0001299_abnormal_eye_distance/0.52506242
95MP0000371_diluted_coat_color0.50738048
96MP0001501_abnormal_sleep_pattern0.50443773
97MP0001486_abnormal_startle_reflex0.49996720
98MP0002111_abnormal_tail_morphology0.49559530
99MP0005167_abnormal_blood-brain_barrier0.49365152
100MP0004233_abnormal_muscle_weight0.48783716

Predicted human phenotypes

RankGene SetZ-score
1Short tibia (HP:0005736)4.66204187
2Fibular aplasia (HP:0002990)4.61924072
3Aplasia/Hypoplasia of the tibia (HP:0005772)4.54112151
4Death in childhood (HP:0003819)4.07645793
5Hypoplasia of the pons (HP:0012110)4.06485022
6Aplasia involving bones of the extremities (HP:0009825)3.66898497
7Aplasia involving bones of the upper limbs (HP:0009823)3.66898497
8Aplasia of the phalanges of the hand (HP:0009802)3.66898497
9Abnormality of incisor morphology (HP:0011063)3.64853625
10Abnormality of the pons (HP:0007361)3.63957557
11Pancreatic fibrosis (HP:0100732)3.58345461
12Acute necrotizing encephalopathy (HP:0006965)3.31427187
13Molar tooth sign on MRI (HP:0002419)3.26598930
14Abnormality of midbrain morphology (HP:0002418)3.26598930
15Progressive microcephaly (HP:0000253)3.26158787
16Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.25618535
17Pancreatic cysts (HP:0001737)3.12020739
18Nephronophthisis (HP:0000090)3.09527698
19Abnormality of dental color (HP:0011073)3.04034206
20Scotoma (HP:0000575)3.03088797
21Aplasia/Hypoplasia of the tongue (HP:0010295)3.01312420
22Rib fusion (HP:0000902)2.94543367
23Abnormal mitochondria in muscle tissue (HP:0008316)2.93354914
24Rectal fistula (HP:0100590)2.91851493
25Rectovaginal fistula (HP:0000143)2.91851493
26Long foot (HP:0001833)2.84508578
27Entropion (HP:0000621)2.79364671
28Abnormality of the incisor (HP:0000676)2.77366753
29Vaginal fistula (HP:0004320)2.76901775
30Acute encephalopathy (HP:0006846)2.74794192
31Acute lymphatic leukemia (HP:0006721)2.69090518
32Abnormality of the thoracic spine (HP:0100711)2.68801409
33Intestinal fistula (HP:0100819)2.68201713
34Postaxial foot polydactyly (HP:0001830)2.64602948
35Aplasia/Hypoplasia of the earlobes (HP:0009906)2.63975636
36Septate vagina (HP:0001153)2.62912448
37Decreased subcutaneous fat (HP:0001002)2.62146923
38Increased CSF lactate (HP:0002490)2.54908031
39Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.51969624
40Short 1st metacarpal (HP:0010034)2.51969624
41Progressive macrocephaly (HP:0004481)2.50170008
42Anterior segment dysgenesis (HP:0007700)2.37649762
43Abnormal number of incisors (HP:0011064)2.33132581
44Growth hormone deficiency (HP:0000824)2.32311356
45True hermaphroditism (HP:0010459)2.30129908
46Duplication of thumb phalanx (HP:0009942)2.26010910
47Mitochondrial inheritance (HP:0001427)2.25312505
48Truncal obesity (HP:0001956)2.24406251
49Long clavicles (HP:0000890)2.24353680
50Neoplasm of the adrenal cortex (HP:0100641)2.23868329
51Abnormality of the 1st metacarpal (HP:0010009)2.19899850
52Cerebral hypomyelination (HP:0006808)2.19096537
53Abnormality of the renal medulla (HP:0100957)2.18468372
54Hypokinesia (HP:0002375)2.17681932
55Absent radius (HP:0003974)2.14916832
56Hypoproteinemia (HP:0003075)2.13589937
57Congenital sensorineural hearing impairment (HP:0008527)2.12573893
58Supernumerary bones of the axial skeleton (HP:0009144)2.09086232
59Aplasia/hypoplasia of the humerus (HP:0006507)2.08638535
60Congenital primary aphakia (HP:0007707)2.07861247
61Abnormality of subcutaneous fat tissue (HP:0001001)2.07407359
62Abnormality of the phalanges of the hallux (HP:0010057)2.06670095
63Abnormality of DNA repair (HP:0003254)2.06507523
64Opisthotonus (HP:0002179)2.05619748
65Gait imbalance (HP:0002141)2.04911351
66Sclerocornea (HP:0000647)2.02731546
67Aplasia involving forearm bones (HP:0009822)2.00461930
68Absent forearm bone (HP:0003953)2.00461930
69Methylmalonic acidemia (HP:0002912)1.98855976
70Tubular atrophy (HP:0000092)1.98730160
71Neoplasm of head and neck (HP:0012288)1.98593340
72Esophageal neoplasm (HP:0100751)1.98593340
73Medial flaring of the eyebrow (HP:0010747)1.97973476
74Cerebellar hypoplasia (HP:0001321)1.96493238
75Congenital stationary night blindness (HP:0007642)1.96090634
76Aplasia/Hypoplasia of the fibula (HP:0006492)1.94848069
77Renal cortical cysts (HP:0000803)1.94753940
78Abnormality of alanine metabolism (HP:0010916)1.93560509
79Hyperalaninemia (HP:0003348)1.93560509
80Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.93560509
81Prominent metopic ridge (HP:0005487)1.92322093
82Tongue fasciculations (HP:0001308)1.91670581
83Preaxial hand polydactyly (HP:0001177)1.91470401
84Ileus (HP:0002595)1.90729870
85Hypoplasia of the brainstem (HP:0002365)1.88118340
86Aplasia/Hypoplasia of the brainstem (HP:0007362)1.88118340
87Hypoplasia of the fovea (HP:0007750)1.86303684
88Aplasia/Hypoplasia of the fovea (HP:0008060)1.86303684
89Supernumerary ribs (HP:0005815)1.85432209
90Type II lissencephaly (HP:0007260)1.83164410
91Poikiloderma (HP:0001029)1.82577576
92Cerebellar dysplasia (HP:0007033)1.82554035
93Nephrogenic diabetes insipidus (HP:0009806)1.82341356
94Rough bone trabeculation (HP:0100670)1.80680466
95Preauricular skin tag (HP:0000384)1.78500957
96Broad-based gait (HP:0002136)1.78175313
97Preaxial foot polydactyly (HP:0001841)1.76257908
98Chromsome breakage (HP:0040012)1.76178660
99Abnormal biliary tract physiology (HP:0012439)1.75063179
100Bile duct proliferation (HP:0001408)1.75063179

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K28.34555448
2NEK14.68427744
3MUSK3.94597759
4CCNB13.67540423
5LATS13.43248730
6NUAK13.16797567
7VRK22.65378263
8MAP3K112.37920574
9WNK32.25714580
10LMTK22.04549339
11PLK41.85172891
12PDK21.64548501
13BCKDK1.62122306
14NME11.42262680
15SRPK11.32707034
16TLK11.28343817
17NTRK31.27495775
18NEK61.26766907
19ZAK1.23335844
20EPHA41.22636810
21WNK41.22051350
22TAOK31.20229891
23TAF11.18867612
24VRK11.16962534
25MST41.16338094
26ADRBK21.08732491
27GRK61.07456870
28MAP3K121.06020412
29PRKD21.00840810
30STK30.96922606
31CHEK20.89610981
32MAP2K20.85781556
33TNIK0.84929298
34GRK10.83086937
35PRKCG0.78777647
36PLK10.77321608
37OXSR10.75367354
38STK240.73470414
39MAP3K40.71587306
40NEK20.70646083
41SIK20.70442275
42STK390.69333038
43MAP3K50.69247620
44DAPK30.67283753
45CHEK10.66520946
46NTRK20.65917614
47CAMK1D0.63927729
48TXK0.63893187
49MAP2K70.63883136
50ATR0.63437857
51FRK0.55263178
52BUB10.51684075
53PAK10.51540869
54TSSK60.50911670
55IKBKB0.49918470
56PINK10.47344031
57MARK10.45343001
58LIMK10.44012079
59SIK30.43754790
60ADRBK10.43591800
61MAP2K40.43375617
62MAPK90.43226311
63MAP2K30.42902479
64MAP3K140.42468107
65PRKACB0.41861630
66EIF2AK20.41825516
67MAPK70.41763077
68STK38L0.41545689
69PKN10.41197190
70CSNK2A10.40043301
71PIM10.38840014
72AURKA0.38749691
73WEE10.38653266
74ABL20.38620835
75PRKCD0.37285402
76CDK11A0.37206160
77PLK30.36477703
78MAPKAPK20.36464342
79CDK30.36456631
80CDC70.35451574
81BTK0.35209884
82DYRK20.35154182
83CAMK1G0.35044598
84IKBKE0.34492326
85CDK10.34112695
86GSK3B0.32849689
87PLK20.31885676
88PIK3CA0.31444338
89RPS6KB10.30660882
90CDK20.30513914
91AURKB0.30035707
92INSRR0.29526418
93CAMK10.29269221
94MATK0.28600278
95FGFR10.27876818
96PIM20.27152853
97PRKCQ0.26714822
98CDK70.26230810
99MELK0.26214436
100MAPK100.26113788

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.61826875
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.62051199
3Non-homologous end-joining_Homo sapiens_hsa034503.54961912
4Phototransduction_Homo sapiens_hsa047442.90716685
5Sulfur relay system_Homo sapiens_hsa041222.77670856
6Base excision repair_Homo sapiens_hsa034102.69438995
7Ribosome_Homo sapiens_hsa030102.58710910
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.53916473
9Basal transcription factors_Homo sapiens_hsa030222.49738183
10Proteasome_Homo sapiens_hsa030502.24535543
11Homologous recombination_Homo sapiens_hsa034402.06761785
12Oxidative phosphorylation_Homo sapiens_hsa001902.05710498
13Nitrogen metabolism_Homo sapiens_hsa009102.05059760
14RNA polymerase_Homo sapiens_hsa030201.90296722
15RNA degradation_Homo sapiens_hsa030181.77523632
16Lysine degradation_Homo sapiens_hsa003101.75094246
17Parkinsons disease_Homo sapiens_hsa050121.73949953
18Spliceosome_Homo sapiens_hsa030401.70511045
19Regulation of autophagy_Homo sapiens_hsa041401.59985706
20Fanconi anemia pathway_Homo sapiens_hsa034601.59598603
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.54979614
22mRNA surveillance pathway_Homo sapiens_hsa030151.52716154
23Pyrimidine metabolism_Homo sapiens_hsa002401.45971683
24One carbon pool by folate_Homo sapiens_hsa006701.43567651
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.41361482
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33694028
27Protein export_Homo sapiens_hsa030601.32453693
28Caffeine metabolism_Homo sapiens_hsa002321.31638722
29RNA transport_Homo sapiens_hsa030131.30300774
30Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.29340985
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.23694212
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.22733073
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.21879380
34Huntingtons disease_Homo sapiens_hsa050161.19824792
35Linoleic acid metabolism_Homo sapiens_hsa005911.18450153
36Cardiac muscle contraction_Homo sapiens_hsa042601.16349435
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.13925869
38Purine metabolism_Homo sapiens_hsa002301.12719523
39DNA replication_Homo sapiens_hsa030301.10774556
40Mismatch repair_Homo sapiens_hsa034301.06047867
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.03044384
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.02410791
43Alzheimers disease_Homo sapiens_hsa050100.99869686
44Oocyte meiosis_Homo sapiens_hsa041140.97227239
45Dorso-ventral axis formation_Homo sapiens_hsa043200.89866364
46Cell cycle_Homo sapiens_hsa041100.88178508
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87258963
48Pyruvate metabolism_Homo sapiens_hsa006200.86689411
49Chemical carcinogenesis_Homo sapiens_hsa052040.82630876
50Arginine biosynthesis_Homo sapiens_hsa002200.81878163
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81037182
52Nucleotide excision repair_Homo sapiens_hsa034200.80990271
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78472346
54p53 signaling pathway_Homo sapiens_hsa041150.77855689
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76339426
56Fatty acid elongation_Homo sapiens_hsa000620.75315498
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75261145
58Ether lipid metabolism_Homo sapiens_hsa005650.74725881
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73501506
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.72986166
61Primary immunodeficiency_Homo sapiens_hsa053400.68404986
62Fat digestion and absorption_Homo sapiens_hsa049750.67683960
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65541180
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.64600882
65Collecting duct acid secretion_Homo sapiens_hsa049660.61356254
66Salivary secretion_Homo sapiens_hsa049700.60966161
67Phenylalanine metabolism_Homo sapiens_hsa003600.57093640
68Arachidonic acid metabolism_Homo sapiens_hsa005900.56268103
69Tyrosine metabolism_Homo sapiens_hsa003500.55998184
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.54729251
71Asthma_Homo sapiens_hsa053100.52380013
72Hedgehog signaling pathway_Homo sapiens_hsa043400.52294279
73Glycerolipid metabolism_Homo sapiens_hsa005610.49874704
74Metabolic pathways_Homo sapiens_hsa011000.49302795
75TGF-beta signaling pathway_Homo sapiens_hsa043500.48627260
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46852378
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45470435
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45106103
79Carbon metabolism_Homo sapiens_hsa012000.43224090
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.41233607
81Nicotine addiction_Homo sapiens_hsa050330.41024436
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40281570
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40200317
84Apoptosis_Homo sapiens_hsa042100.37224390
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.36743764
86Butanoate metabolism_Homo sapiens_hsa006500.35713946
87Pancreatic secretion_Homo sapiens_hsa049720.33748272
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32119085
892-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.28553165
90Calcium signaling pathway_Homo sapiens_hsa040200.27824598
91Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.27473551
92Legionellosis_Homo sapiens_hsa051340.27134293
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.26914879
94Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26264300
95Vitamin digestion and absorption_Homo sapiens_hsa049770.25404501
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25012006
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23587094
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22223069
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.20153569
100Propanoate metabolism_Homo sapiens_hsa006400.18689852

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