MRS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sodium ion export (GO:0071436)6.09679085
2lysine metabolic process (GO:0006553)5.23018955
3lysine catabolic process (GO:0006554)5.23018955
4negative regulation of cell size (GO:0045792)4.58831549
5tricarboxylic acid cycle (GO:0006099)4.54365449
6carnitine shuttle (GO:0006853)4.32277169
7DNA replication checkpoint (GO:0000076)4.27930865
8cell communication by electrical coupling (GO:0010644)4.27126463
9cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.26684660
10IMP biosynthetic process (GO:0006188)4.21471568
11carnitine transmembrane transport (GO:1902603)4.11018941
12carnitine transport (GO:0015879)4.01222458
13amino-acid betaine transport (GO:0015838)4.01222458
14fatty acid transmembrane transport (GO:1902001)3.97538033
152-oxoglutarate metabolic process (GO:0006103)3.94221331
16ribosome assembly (GO:0042255)3.94123358
17IMP metabolic process (GO:0046040)3.90986540
18DNA double-strand break processing (GO:0000729)3.90096885
19tricarboxylic acid metabolic process (GO:0072350)3.89757597
20aspartate family amino acid catabolic process (GO:0009068)3.86986009
21macroautophagy (GO:0016236)3.85082460
22regulation of fatty acid beta-oxidation (GO:0031998)3.80136513
23chromatin remodeling at centromere (GO:0031055)3.76797700
24nuclear pore complex assembly (GO:0051292)3.72709068
25establishment of integrated proviral latency (GO:0075713)3.70163895
26CENP-A containing nucleosome assembly (GO:0034080)3.68182378
27CDP-diacylglycerol metabolic process (GO:0046341)3.63484064
28regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.52177399
29CDP-diacylglycerol biosynthetic process (GO:0016024)3.51466292
30positive regulation of histone deacetylation (GO:0031065)3.47162930
31regulation of fatty acid oxidation (GO:0046320)3.47067193
32DNA damage response, detection of DNA damage (GO:0042769)3.44946908
33mitotic metaphase plate congression (GO:0007080)3.44535845
34regulation of posttranscriptional gene silencing (GO:0060147)3.43107902
35regulation of gene silencing by miRNA (GO:0060964)3.43107902
36regulation of gene silencing by RNA (GO:0060966)3.43107902
37proteasome assembly (GO:0043248)3.42917614
38regulation of helicase activity (GO:0051095)3.41315617
39L-serine metabolic process (GO:0006563)3.40195849
40peptidyl-lysine dimethylation (GO:0018027)3.40104940
41purine nucleobase biosynthetic process (GO:0009113)3.39416113
42pre-miRNA processing (GO:0031054)3.34792411
43positive regulation of triglyceride biosynthetic process (GO:0010867)3.34664930
44protein localization to kinetochore (GO:0034501)3.30922661
45fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.29938695
46COPI coating of Golgi vesicle (GO:0048205)3.28575250
47Golgi transport vesicle coating (GO:0048200)3.28575250
48maturation of 5.8S rRNA (GO:0000460)3.27724317
49alpha-linolenic acid metabolic process (GO:0036109)3.26928499
50cellular potassium ion homeostasis (GO:0030007)3.25413654
51NADH metabolic process (GO:0006734)3.24923341
52DNA strand elongation involved in DNA replication (GO:0006271)3.24742200
53mitochondrial RNA metabolic process (GO:0000959)3.24528468
54antigen processing and presentation via MHC class Ib (GO:0002475)3.23886048
55negative regulation of cytosolic calcium ion concentration (GO:0051481)3.23490514
56cytoplasmic mRNA processing body assembly (GO:0033962)3.23237222
57negative regulation of DNA-dependent DNA replication (GO:2000104)3.22732669
58valine metabolic process (GO:0006573)3.22552009
59histone exchange (GO:0043486)3.21271292
60pentose-phosphate shunt (GO:0006098)3.20452916
61oxaloacetate metabolic process (GO:0006107)3.17834508
62mannose metabolic process (GO:0006013)3.17072322
63regulation of centriole replication (GO:0046599)3.17017960
64transcription from mitochondrial promoter (GO:0006390)3.16286238
65regulation of mitochondrial translation (GO:0070129)3.15568814
66cell communication involved in cardiac conduction (GO:0086065)3.14056255
67somatic diversification of immune receptors via somatic mutation (GO:0002566)3.10133718
68somatic hypermutation of immunoglobulin genes (GO:0016446)3.10133718
69regulation of mitotic spindle checkpoint (GO:1903504)3.09518516
70regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.09518516
71nucleobase biosynthetic process (GO:0046112)3.07293523
72DNA strand elongation (GO:0022616)3.06319504
73nuclear pore organization (GO:0006999)3.04394773
74negative regulation of fatty acid biosynthetic process (GO:0045717)3.03366297
75regulation of translational termination (GO:0006449)3.02215305
76non-recombinational repair (GO:0000726)3.02212503
77double-strand break repair via nonhomologous end joining (GO:0006303)3.02212503
78ncRNA catabolic process (GO:0034661)3.00894956
79DNA catabolic process, exonucleolytic (GO:0000738)2.99140709
80dicarboxylic acid biosynthetic process (GO:0043650)2.98575609
81metaphase plate congression (GO:0051310)2.96781177
82positive regulation of fatty acid beta-oxidation (GO:0032000)2.95766859
83regulation of acyl-CoA biosynthetic process (GO:0050812)2.95761557
84positive regulation of SMAD protein import into nucleus (GO:0060391)2.95540261
85telomere maintenance via semi-conservative replication (GO:0032201)2.95047941
86positive regulation of triglyceride metabolic process (GO:0090208)2.94573572
87cullin deneddylation (GO:0010388)2.93799357
88regulation of cholesterol homeostasis (GO:2000188)2.93726214
89tRNA aminoacylation for protein translation (GO:0006418)2.93486253
90regulation of translational fidelity (GO:0006450)2.92194252
91DNA replication-independent nucleosome assembly (GO:0006336)2.92024074
92DNA replication-independent nucleosome organization (GO:0034724)2.92024074
93regulation of coenzyme metabolic process (GO:0051196)2.90071633
94regulation of cofactor metabolic process (GO:0051193)2.90071633
95tRNA aminoacylation (GO:0043039)2.88811167
96amino acid activation (GO:0043038)2.88811167
97folic acid-containing compound biosynthetic process (GO:0009396)2.88530118
98quaternary ammonium group transport (GO:0015697)2.87692847
99chaperone-mediated protein transport (GO:0072321)2.86367856
100cysteine metabolic process (GO:0006534)2.86102479
101activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.85488613
102pteridine-containing compound biosynthetic process (GO:0042559)2.85235806
103regulation of sequestering of triglyceride (GO:0010889)2.84774135
104amino-acid betaine metabolic process (GO:0006577)2.83607663
105protein localization to chromosome, centromeric region (GO:0071459)2.81492189
106negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.79715116
107negative regulation of mitotic sister chromatid separation (GO:2000816)2.79625409
108negative regulation of sister chromatid segregation (GO:0033046)2.79625409
109negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.79625409
110negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.79625409
111negative regulation of mitotic sister chromatid segregation (GO:0033048)2.79625409
112regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.79478895
113cellular sodium ion homeostasis (GO:0006883)2.79455142
114cell fate commitment involved in formation of primary germ layer (GO:0060795)2.79420402
115beta-amyloid metabolic process (GO:0050435)2.78669782
116negative regulation of chromosome segregation (GO:0051985)2.78662968
117positive regulation of nuclease activity (GO:0032075)2.77166776
118positive thymic T cell selection (GO:0045059)2.76659500
119regulation of DNA endoreduplication (GO:0032875)2.75808007
120somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.75046219
121isotype switching (GO:0045190)2.75046219
122somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.75046219
123response to pheromone (GO:0019236)2.73697330
124establishment of viral latency (GO:0019043)2.73657929
125succinate metabolic process (GO:0006105)2.73653393
1264-hydroxyproline metabolic process (GO:0019471)2.73067600
127protein complex localization (GO:0031503)2.72803815
128mitotic spindle checkpoint (GO:0071174)2.72645092
129protein deneddylation (GO:0000338)2.72603000
130DNA unwinding involved in DNA replication (GO:0006268)2.72556955
131positive regulation of glycolytic process (GO:0045821)2.71349591
132regulation of triglyceride catabolic process (GO:0010896)2.70237939
133respiratory chain complex IV assembly (GO:0008535)2.69347955
134negative regulation of organelle assembly (GO:1902116)2.68144287
135spindle checkpoint (GO:0031577)2.68122831
136mitotic G1 DNA damage checkpoint (GO:0031571)2.67611810
137fatty acid homeostasis (GO:0055089)2.66954542
138RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.66495293
139fatty acid beta-oxidation (GO:0006635)2.66252813
140NADPH regeneration (GO:0006740)2.65856659
141acetyl-CoA metabolic process (GO:0006084)2.65790499
142regulation of chromosome segregation (GO:0051983)2.65702843
143urea metabolic process (GO:0019627)2.65532033
144urea cycle (GO:0000050)2.65532033
145mitotic sister chromatid cohesion (GO:0007064)2.64722572
146regulation of NFAT protein import into nucleus (GO:0051532)2.64613610
147regulation of fatty acid biosynthetic process (GO:0042304)2.64306364
148negative regulation of DNA recombination (GO:0045910)2.63606882
149positive regulation of synapse maturation (GO:0090129)2.63438827
150establishment of protein localization to mitochondrial membrane (GO:0090151)2.63183771
151negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.62985483
152positive regulation of chromosome segregation (GO:0051984)2.62758984
153telomere maintenance via recombination (GO:0000722)2.62578358
154regulation of ARF protein signal transduction (GO:0032012)2.62575844
155regulation of mitotic metaphase/anaphase transition (GO:0030071)2.62430343
156regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.62430343
157DNA strand renaturation (GO:0000733)2.62249836
158melanin biosynthetic process (GO:0042438)2.61756357
159plasma membrane repair (GO:0001778)2.60943982
160formation of translation preinitiation complex (GO:0001731)2.60625028
161regulation of gamma-delta T cell differentiation (GO:0045586)2.60239200
162DNA replication-dependent nucleosome assembly (GO:0006335)2.59638937
163DNA replication-dependent nucleosome organization (GO:0034723)2.59638937
164pseudouridine synthesis (GO:0001522)2.59402277
165glutamine metabolic process (GO:0006541)2.59243356
166phospholipid homeostasis (GO:0055091)2.58523792
167positive regulation of fatty acid oxidation (GO:0046321)2.58274787
168intracellular lipid transport (GO:0032365)2.58193797
169negative regulation of potassium ion transmembrane transport (GO:1901380)2.56741478
170histone mRNA metabolic process (GO:0008334)2.56189257
171negative regulation of fatty acid metabolic process (GO:0045922)2.56154118
172regulation of sister chromatid segregation (GO:0033045)2.55598672
173regulation of mitotic sister chromatid separation (GO:0010965)2.55598672
174regulation of mitotic sister chromatid segregation (GO:0033047)2.55598672
175oxidative phosphorylation (GO:0006119)2.55333680
176short-chain fatty acid metabolic process (GO:0046459)2.53861336
177biotin metabolic process (GO:0006768)2.52555651
178regulation of fatty acid metabolic process (GO:0019217)2.52051264
179gene silencing by RNA (GO:0031047)2.51068797
180retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.50912814
181regulation of p38MAPK cascade (GO:1900744)2.49356941
182regulation of nuclease activity (GO:0032069)2.48662802
183positive regulation of gamma-delta T cell activation (GO:0046645)2.46083496
184response to inactivity (GO:0014854)2.45534375
185regulation of sulfur metabolic process (GO:0042762)2.44437969
186glycolytic process (GO:0006096)2.42671905
187regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.42414377
188cardiac muscle contraction (GO:0060048)2.42322485

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.31235451
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.61925400
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.44574875
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.38601325
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.33805501
6MYC_22102868_ChIP-Seq_BL_Human3.29412264
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.23902180
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.23894304
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.03194580
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.87705876
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.87247239
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.83295339
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.72274160
14* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.72118481
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.67889363
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.58632416
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.58608820
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.52630253
19RXR_22158963_ChIP-Seq_LIVER_Mouse2.48040026
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.43882143
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.42232948
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.40527129
23RBPJ_22232070_ChIP-Seq_NCS_Mouse2.40490674
24* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.39597664
25TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.34509437
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.32631906
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.30954527
28ELK1_19687146_ChIP-ChIP_HELA_Human2.28803452
29TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.26672627
30TCF7_22412390_ChIP-Seq_EML_Mouse2.23772580
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.21340482
32KDM2B_26808549_Chip-Seq_DND41_Human2.19588676
33ZNF263_19887448_ChIP-Seq_K562_Human2.12984217
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.11310803
35MYC_19079543_ChIP-ChIP_MESCs_Mouse2.09977233
36MYC_18358816_ChIP-ChIP_MESCs_Mouse2.09027720
37NELFA_20434984_ChIP-Seq_ESCs_Mouse2.08723809
38KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.03920709
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.99163101
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.95353569
41E2F1_18555785_ChIP-Seq_MESCs_Mouse1.95239057
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.94963013
43EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.94198003
44VDR_23849224_ChIP-Seq_CD4+_Human1.93642798
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.90722124
46DCP1A_22483619_ChIP-Seq_HELA_Human1.89890242
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.89650574
48FOXP3_21729870_ChIP-Seq_TREG_Human1.89511603
49LXR_22292898_ChIP-Seq_THP-1_Human1.88955400
50BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.85346053
51THAP11_20581084_ChIP-Seq_MESCs_Mouse1.85241002
52LXR_22158963_ChIP-Seq_LIVER_Mouse1.83747799
53KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.80671596
54E2F1_21310950_ChIP-Seq_MCF-7_Human1.80608632
55PADI4_21655091_ChIP-ChIP_MCF-7_Human1.78712253
56EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78121049
57ZNF274_21170338_ChIP-Seq_K562_Hela1.78090675
58ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.77777014
59VDR_21846776_ChIP-Seq_THP-1_Human1.76719086
60KDM2B_26808549_Chip-Seq_SUP-B15_Human1.68556885
61TTF2_22483619_ChIP-Seq_HELA_Human1.66965405
62MAF_26560356_Chip-Seq_TH1_Human1.66094654
63MYC_18940864_ChIP-ChIP_HL60_Human1.65650750
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.65244479
65UTX_26944678_Chip-Seq_JUKART_Human1.64736300
66CIITA_25753668_ChIP-Seq_RAJI_Human1.61729203
67E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.59490868
68* GABP_19822575_ChIP-Seq_HepG2_Human1.58153051
69POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57703133
70NANOG_16153702_ChIP-ChIP_HESCs_Human1.56276682
71FLI1_27457419_Chip-Seq_LIVER_Mouse1.54971184
72CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.54463650
73* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.51418266
74XRN2_22483619_ChIP-Seq_HELA_Human1.49859729
75STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.49740257
76MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.49548110
77CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.49204476
78BRD4_27068464_Chip-Seq_AML-cells_Mouse1.49102775
79POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.48552060
80SRF_21415370_ChIP-Seq_HL-1_Mouse1.47937627
81NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.47606997
82DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.47588664
83TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.46433348
84P68_20966046_ChIP-Seq_HELA_Human1.46233307
85FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.45990558
86HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45733399
87STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.45698314
88ATF3_27146783_Chip-Seq_COLON_Human1.43462368
89YY1_21170310_ChIP-Seq_MESCs_Mouse1.43209589
90EWS_26573619_Chip-Seq_HEK293_Human1.42890502
91ELF1_17652178_ChIP-ChIP_JURKAT_Human1.41741159
92ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.40265347
93SOX2_16153702_ChIP-ChIP_HESCs_Human1.39823446
94E2F7_22180533_ChIP-Seq_HELA_Human1.39487608
95KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.39325953
96KLF4_18555785_ChIP-Seq_MESCs_Mouse1.38986582
97VDR_22108803_ChIP-Seq_LS180_Human1.38864349
98ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38802423
99ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.38595093
100* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.37626851
101CLOCK_20551151_ChIP-Seq_293T_Human1.34727148
102POU5F1_16153702_ChIP-ChIP_HESCs_Human1.34522896
103CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.33677763
104GATA1_19941827_ChIP-Seq_MEL_Mouse1.33371405
105FUS_26573619_Chip-Seq_HEK293_Human1.33192383
106MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.32937860
107NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.32821133
108TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.32509176
109PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.31039122
110NANOG_18555785_ChIP-Seq_MESCs_Mouse1.30967374
111ELF1_20517297_ChIP-Seq_JURKAT_Human1.29763759
112TBX20_22080862_ChIP-Seq_HEART_Mouse1.28210557
113TBX20_22328084_ChIP-Seq_HEART_Mouse1.28210557
114ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.26164389
115ELK3_25401928_ChIP-Seq_HUVEC_Human1.24854738
116P300_27058665_Chip-Seq_ZR-75-30cells_Human1.24708164
117FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24006765
118EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.23136952
119KDM2B_26808549_Chip-Seq_K562_Human1.22626666
120IGF1R_20145208_ChIP-Seq_DFB_Human1.22020854
121KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.21464774
122KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.21464774
123KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.21464774
124SOX2_18555785_ChIP-Seq_MESCs_Mouse1.21420232
125RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.20706167
126CREB1_26743006_Chip-Seq_LNCaP_Human1.19994403
127NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.18913327
128FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.17913853
129MYB_26560356_Chip-Seq_TH2_Human1.17782533
130SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.17385323
131PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15748346
132GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15076683
133POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.14897001
134MYB_26560356_Chip-Seq_TH1_Human1.14556233
135HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.13579235
136MAF_26560356_Chip-Seq_TH2_Human1.13193096
137DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.12626792
138KDM2B_26808549_Chip-Seq_JURKAT_Human1.10252248
139GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09670308
140PHF8_20622854_ChIP-Seq_HELA_Human1.09116403
141POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08897950
142AR_21909140_ChIP-Seq_LNCAP_Human1.08445529
143RACK7_27058665_Chip-Seq_MCF-7_Human1.07743943
144E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07700301
145KDM5A_27292631_Chip-Seq_BREAST_Human1.06525107
146RUNX1_22412390_ChIP-Seq_EML_Mouse1.05184598
147GATA6_25053715_ChIP-Seq_YYC3_Human1.04840129
148VDR_24763502_ChIP-Seq_THP-1_Human1.04687932
149ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04213819
150SMC4_20622854_ChIP-Seq_HELA_Human1.04134387
151BCOR_27268052_Chip-Seq_Bcells_Human1.04044838
152PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03697333
153NCOR1_26117541_ChIP-Seq_K562_Human1.02075139
154TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.02047901
155NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.00839882
156GATA1_19941826_ChIP-Seq_K562_Human1.00384877
157SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.99653905
158TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.99199988
159GATA3_27048872_Chip-Seq_THYMUS_Human0.98925484
160RARG_19884340_ChIP-ChIP_MEFs_Mouse0.97974014
161BCL6_27268052_Chip-Seq_Bcells_Human0.96890268
162CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.95267297
163CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95127362
164ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94790351
165FOXA2_19822575_ChIP-Seq_HepG2_Human0.94741076
166MYB_21317192_ChIP-Seq_ERMYB_Mouse0.94315362
167KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93435441
168TCF3_18692474_ChIP-Seq_MEFs_Mouse0.93308367
169SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93177123
170RUNX1_27514584_Chip-Seq_MCF-7_Human0.93046688
171SOX17_20123909_ChIP-Seq_XEN_Mouse0.92824050
172ETS1_21867929_ChIP-Seq_TH2_Mouse0.92551501
173PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.92070574
174TET1_21451524_ChIP-Seq_MESCs_Mouse0.91591369
175ZFX_18555785_ChIP-Seq_MESCs_Mouse0.90888059
176GATA1_22025678_ChIP-Seq_K562_Human0.90717079
177GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.90323596
178FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90075749
179FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.89915929
180RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.87991306
181* P300_19829295_ChIP-Seq_ESCs_Human0.86270166
182ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85071907
183TAF15_26573619_Chip-Seq_HEK293_Human0.84972957
184TCF3_18692474_ChIP-Seq_MESCs_Mouse0.84113492
185GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82614490
186BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.81056633
187SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.80726901
188TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80552352
189IRF1_19129219_ChIP-ChIP_H3396_Human0.78303868
190SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.75961276
191HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.73979075
192TP53_22573176_ChIP-Seq_HFKS_Human0.71757887

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003183_abnormal_peptide_metabolism4.36086158
2MP0004957_abnormal_blastocyst_morpholog3.62552392
3MP0003890_abnormal_embryonic-extraembry3.16200406
4MP0008057_abnormal_DNA_replication3.11325140
5MP0008961_abnormal_basal_metabolism3.05295112
6MP0008058_abnormal_DNA_repair2.94732218
7MP0003646_muscle_fatigue2.94568010
8MP0005360_urolithiasis2.92294587
9MP0000569_abnormal_digit_pigmentation2.81706587
10MP0008877_abnormal_DNA_methylation2.81129994
11MP0003941_abnormal_skin_development2.77373842
12MP0003718_maternal_effect2.73200805
13MP0003300_gastrointestinal_ulcer2.70824926
14MP0004130_abnormal_muscle_cell2.67689424
15MP0002837_dystrophic_cardiac_calcinosis2.52759321
16MP0003172_abnormal_lysosome_physiology2.50504405
17MP0009840_abnormal_foam_cell2.46320990
18MP0008932_abnormal_embryonic_tissue2.46168866
19MP0004084_abnormal_cardiac_muscle2.37203794
20MP0002139_abnormal_hepatobiliary_system2.37201835
21MP0005365_abnormal_bile_salt2.35039590
22MP0005670_abnormal_white_adipose2.30877606
23MP0005423_abnormal_somatic_nervous2.26404926
24MP0003077_abnormal_cell_cycle2.20109975
25MP0003567_abnormal_fetal_cardiomyocyte2.18010309
26MP0004147_increased_porphyrin_level2.14842584
27MP0003705_abnormal_hypodermis_morpholog2.09434220
28MP0002653_abnormal_ependyma_morphology2.08127777
29MP0005666_abnormal_adipose_tissue1.89439888
30MP0001188_hyperpigmentation1.87788874
31MP0003656_abnormal_erythrocyte_physiolo1.84137250
32MP0004233_abnormal_muscle_weight1.82093297
33MP0002269_muscular_atrophy1.79627242
34MP0004215_abnormal_myocardial_fiber1.78937217
35MP0009672_abnormal_birth_weight1.78829273
36MP0009697_abnormal_copulation1.77809758
37MP0001661_extended_life_span1.76794218
38MP0003252_abnormal_bile_duct1.75914673
39MP0004036_abnormal_muscle_relaxation1.73748973
40MP0002909_abnormal_adrenal_gland1.70325420
41MP0002971_abnormal_brown_adipose1.67037885
42MP0003937_abnormal_limbs/digits/tail_de1.64344955
43MP0001529_abnormal_vocalization1.63964649
44MP0006292_abnormal_olfactory_placode1.62804396
45MP0001293_anophthalmia1.62150692
46MP0001666_abnormal_nutrient_absorption1.61675390
47MP0003119_abnormal_digestive_system1.60665353
48MP0000747_muscle_weakness1.60214621
49MP0004133_heterotaxia1.59031653
50MP0005410_abnormal_fertilization1.58488817
51MP0000609_abnormal_liver_physiology1.57344350
52MP0010329_abnormal_lipoprotein_level1.56908364
53MP0000751_myopathy1.54807065
54MP0002877_abnormal_melanocyte_morpholog1.53480426
55MP0004185_abnormal_adipocyte_glucose1.53070464
56MP0008007_abnormal_cellular_replicative1.52957947
57MP0003329_amyloid_beta_deposits1.51451165
58MP0003806_abnormal_nucleotide_metabolis1.51292324
59MP0005085_abnormal_gallbladder_physiolo1.49992231
60MP0005380_embryogenesis_phenotype1.49230689
61MP0001672_abnormal_embryogenesis/_devel1.49230689
62MP0000371_diluted_coat_color1.49057865
63MP0002084_abnormal_developmental_patter1.48959193
64MP0003787_abnormal_imprinting1.48658607
65MP0003121_genomic_imprinting1.48658430
66MP0003195_calcinosis1.47949286
67MP0005083_abnormal_biliary_tract1.44777026
68MP0004087_abnormal_muscle_fiber1.44335138
69MP0003136_yellow_coat_color1.42467420
70MP0001697_abnormal_embryo_size1.42124864
71MP0010307_abnormal_tumor_latency1.39822933
72MP0005332_abnormal_amino_acid1.38784704
73MP0002254_reproductive_system_inflammat1.36834073
74MP0003123_paternal_imprinting1.32108587
75MP0002102_abnormal_ear_morphology1.31006305
76MP0005375_adipose_tissue_phenotype1.29873879
77MP0003984_embryonic_growth_retardation1.28350544
78MP0002085_abnormal_embryonic_tissue1.27139377
79MP0005330_cardiomyopathy1.25971351
80MP0003045_fibrosis1.25667142
81MP0002088_abnormal_embryonic_growth/wei1.25327436
82MP0002938_white_spotting1.22513666
83MP0002166_altered_tumor_susceptibility1.20940812
84MP0006072_abnormal_retinal_apoptosis1.20687792
85MP0000604_amyloidosis1.20048941
86MP0010352_gastrointestinal_tract_polyps1.19936023
87MP0010234_abnormal_vibrissa_follicle1.19168582
88MP0008775_abnormal_heart_ventricle1.16137367
89MP0010630_abnormal_cardiac_muscle1.15662673
90MP0000350_abnormal_cell_proliferation1.15326113
91MP0003221_abnormal_cardiomyocyte_apopto1.12495433
92MP0002080_prenatal_lethality1.12420889
93MP0000358_abnormal_cell_content/1.12305989
94MP0002090_abnormal_vision1.11669070
95MP0005220_abnormal_exocrine_pancreas1.11603443
96MP0002118_abnormal_lipid_homeostasis1.11250326
97MP0005584_abnormal_enzyme/coenzyme_acti1.10206898
98MP0002970_abnormal_white_adipose1.09585888
99MP0002078_abnormal_glucose_homeostasis1.08765558
100MP0003186_abnormal_redox_activity1.07362645
101MP0002160_abnormal_reproductive_system1.07060697
102MP0005319_abnormal_enzyme/_coenzyme1.06354404
103MP0003137_abnormal_impulse_conducting1.05714326
104MP0004859_abnormal_synaptic_plasticity1.03337496
105MP0004197_abnormal_fetal_growth/weight/1.03279230
106MP0009703_decreased_birth_body1.02592653
107MP0005076_abnormal_cell_differentiation1.02217619
108MP0003303_peritoneal_inflammation1.00503412
109MP0003191_abnormal_cellular_cholesterol0.99450056
110MP0009384_cardiac_valve_regurgitation0.99092529
111MP0000372_irregular_coat_pigmentation0.97450812
112MP0009643_abnormal_urine_homeostasis0.96794671
113MP0003122_maternal_imprinting0.96371346
114MP0004145_abnormal_muscle_electrophysio0.93799152
115MP0002210_abnormal_sex_determination0.92776953
116MP0002697_abnormal_eye_size0.91697987
117MP0003763_abnormal_thymus_physiology0.90754146
118MP0001286_abnormal_eye_development0.90749569
119MP0008995_early_reproductive_senescence0.89375883
120MP0003786_premature_aging0.89096113
121MP0002086_abnormal_extraembryonic_tissu0.88294638
122MP0002106_abnormal_muscle_physiology0.86944114
123MP0005084_abnormal_gallbladder_morpholo0.86930414
124MP0000537_abnormal_urethra_morphology0.86817329
125MP0000013_abnormal_adipose_tissue0.86527765
126MP0001544_abnormal_cardiovascular_syste0.85854982
127MP0005385_cardiovascular_system_phenoty0.85854982
128MP0001730_embryonic_growth_arrest0.85719554
129MP0005187_abnormal_penis_morphology0.85522749
130MP0001145_abnormal_male_reproductive0.85381787
131MP0004043_abnormal_pH_regulation0.85368578
132MP0002111_abnormal_tail_morphology0.85101709
133MP0000759_abnormal_skeletal_muscle0.84536762
134MP0006036_abnormal_mitochondrial_physio0.84183350
135MP0003959_abnormal_lean_body0.82196441
136MP0001944_abnormal_pancreas_morphology0.81731923
137MP0000003_abnormal_adipose_tissue0.81590797
138MP0003566_abnormal_cell_adhesion0.80949174
139MP0002638_abnormal_pupillary_reflex0.79100953
140MP0005395_other_phenotype0.78269684
141MP0005551_abnormal_eye_electrophysiolog0.77774077
142MP0004808_abnormal_hematopoietic_stem0.77585649
143MP0000733_abnormal_muscle_development0.76910711
144MP0000750_abnormal_muscle_regeneration0.76763639
145MP0003693_abnormal_embryo_hatching0.76321480
146MP0004947_skin_inflammation0.75518457
147MP0003698_abnormal_male_reproductive0.75360952
148MP0000653_abnormal_sex_gland0.75220366
149MP0002972_abnormal_cardiac_muscle0.74747741
150MP0003111_abnormal_nucleus_morphology0.74288392
151MP0000313_abnormal_cell_death0.73612078
152MP0006035_abnormal_mitochondrial_morpho0.72743301
153MP0001873_stomach_inflammation0.72184476
154MP0003866_abnormal_defecation0.71217114
155MP0005058_abnormal_lysosome_morphology0.70927610
156MP0001324_abnormal_eye_pigmentation0.70060417
157MP0003315_abnormal_perineum_morphology0.69992443
158MP0005620_abnormal_muscle_contractility0.69224480
159MP0001984_abnormal_olfaction0.69104113
160MP0001929_abnormal_gametogenesis0.68417443
161MP0010094_abnormal_chromosome_stability0.67741489
162MP0008770_decreased_survivor_rate0.67630599
163MP0000703_abnormal_thymus_morphology0.66901624
164MP0000647_abnormal_sebaceous_gland0.66260713
165MP0000598_abnormal_liver_morphology0.65879690
166MP0001764_abnormal_homeostasis0.65381763
167MP0002233_abnormal_nose_morphology0.64829488
168MP0000749_muscle_degeneration0.64541136
169MP0002796_impaired_skin_barrier0.62758594
170MP0000579_abnormal_nail_morphology0.62100234
171MP0003861_abnormal_nervous_system0.62035302

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)4.59495660
2Elfin facies (HP:0004428)4.12446905
3Insomnia (HP:0100785)3.95286259
4Myoglobinuria (HP:0002913)3.41794910
5Renovascular hypertension (HP:0100817)3.40722956
6Abnormality of the lower motor neuron (HP:0002366)3.37764619
7Hyporeflexia of lower limbs (HP:0002600)3.31332712
8Methylmalonic acidemia (HP:0002912)3.28136170
9Colon cancer (HP:0003003)3.20461460
10Hypoglycemic coma (HP:0001325)3.20318999
11Abnormality of the labia minora (HP:0012880)3.07469839
12Hyperglycinemia (HP:0002154)3.02413881
13Increased hepatocellular lipid droplets (HP:0006565)2.97155071
14Exercise-induced myalgia (HP:0003738)2.94374268
15Ketoacidosis (HP:0001993)2.90157214
16Overriding aorta (HP:0002623)2.89222783
17Ketosis (HP:0001946)2.84637798
18Chromsome breakage (HP:0040012)2.84427935
19Rhabdomyolysis (HP:0003201)2.83156315
20Multiple enchondromatosis (HP:0005701)2.82436562
21Abnormality of methionine metabolism (HP:0010901)2.82117290
22Pancreatic islet-cell hyperplasia (HP:0004510)2.79539209
23Sudden death (HP:0001699)2.74937427
24Increased serum pyruvate (HP:0003542)2.74907655
25Lipid accumulation in hepatocytes (HP:0006561)2.74493505
26Chromosomal breakage induced by crosslinking agents (HP:0003221)2.70910745
27Asymmetric septal hypertrophy (HP:0001670)2.67027545
28Abnormality of serum amino acid levels (HP:0003112)2.66829615
29Hand muscle atrophy (HP:0009130)2.63234098
30Difficulty running (HP:0009046)2.62765565
31Dysmetric saccades (HP:0000641)2.62275387
32Exercise-induced muscle cramps (HP:0003710)2.61849559
33Abnormality of aspartate family amino acid metabolism (HP:0010899)2.60961604
34Methylmalonic aciduria (HP:0012120)2.54896524
35Neoplasm of the adrenal gland (HP:0100631)2.54086298
36Hyperammonemia (HP:0001987)2.51021996
37Birth length less than 3rd percentile (HP:0003561)2.50562337
38Abnormality of glycolysis (HP:0004366)2.50023860
39Gout (HP:0001997)2.48191547
40Bundle branch block (HP:0011710)2.48142196
41Nasal polyposis (HP:0100582)2.46819265
42Hypoplasia of the pons (HP:0012110)2.46586160
43Ventricular fibrillation (HP:0001663)2.45458730
44Recurrent bronchitis (HP:0002837)2.43672759
45Nephroblastoma (Wilms tumor) (HP:0002667)2.43162524
46Meckel diverticulum (HP:0002245)2.38927151
47Renal duplication (HP:0000075)2.36947715
48Bowel diverticulosis (HP:0005222)2.35774522
49Abnormality of the pons (HP:0007361)2.35598177
50Increased CSF lactate (HP:0002490)2.35484376
51Distal upper limb amyotrophy (HP:0007149)2.35343034
52Upper limb amyotrophy (HP:0009129)2.35343034
53Megalocornea (HP:0000485)2.34248992
54Reduced antithrombin III activity (HP:0001976)2.33931749
55Atrioventricular block (HP:0001678)2.33022981
56Abnormality of chromosome stability (HP:0003220)2.32348024
57Abnormality of the ileum (HP:0001549)2.32293323
58Flat cornea (HP:0007720)2.31533610
59Embryonal renal neoplasm (HP:0011794)2.31308968
60Abnormality of alanine metabolism (HP:0010916)2.30512904
61Hyperalaninemia (HP:0003348)2.30512904
62Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.30512904
63Hepatoblastoma (HP:0002884)2.29881263
64Acute encephalopathy (HP:0006846)2.28443219
65Cerebral aneurysm (HP:0004944)2.27449109
66Abnormality of homocysteine metabolism (HP:0010919)2.27369819
67Homocystinuria (HP:0002156)2.27369819
68Acute necrotizing encephalopathy (HP:0006965)2.25827931
69Hyperglycinuria (HP:0003108)2.25116235
70Type I transferrin isoform profile (HP:0003642)2.24454987
71Heterotopia (HP:0002282)2.24234146
72Flat acetabular roof (HP:0003180)2.21509664
73Palpitations (HP:0001962)2.20880320
74Right ventricular cardiomyopathy (HP:0011663)2.20457106
75Difficulty climbing stairs (HP:0003551)2.20174554
76Volvulus (HP:0002580)2.20173532
77Abnormality of the preputium (HP:0100587)2.17564839
78Frequent falls (HP:0002359)2.13734008
79Neoplasm of the adrenal cortex (HP:0100641)2.13141759
80Neuroendocrine neoplasm (HP:0100634)2.12447993
81Progressive muscle weakness (HP:0003323)2.12413892
82Abnormality of the nasal mucosa (HP:0000433)2.10779142
83Microvesicular hepatic steatosis (HP:0001414)2.10440414
84Increased serum lactate (HP:0002151)2.10193017
85Abnormal mitochondria in muscle tissue (HP:0008316)2.08966496
86Death in childhood (HP:0003819)2.08771490
87Abnormal lung lobation (HP:0002101)2.08706679
88Long toe (HP:0010511)2.07641822
89Abnormality of the Achilles tendon (HP:0005109)2.07251675
90Abnormality of the pancreatic islet cells (HP:0006476)2.05745032
91Abnormality of endocrine pancreas physiology (HP:0012093)2.05745032
92Ependymoma (HP:0002888)2.05656711
93Aplasia/Hypoplasia of the uvula (HP:0010293)2.05641890
94Late onset (HP:0003584)2.03955854
95Hypoalphalipoproteinemia (HP:0003233)2.03188360
96Achilles tendon contracture (HP:0001771)2.01727903
97Polycythemia (HP:0001901)1.99950000
98Ventricular tachycardia (HP:0004756)1.99862625
99Abnormality of the vitamin B12 metabolism (HP:0004341)1.99757167
100Urinary urgency (HP:0000012)1.99218679
101Pointed chin (HP:0000307)1.98997427
102Abnormality of sulfur amino acid metabolism (HP:0004339)1.98300624
103Decreased activity of mitochondrial respiratory chain (HP:0008972)1.96085901
104Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.96085901
105Progressive inability to walk (HP:0002505)1.95785229
106Abnormality of glutamine family amino acid metabolism (HP:0010902)1.95605667
107Polygenic inheritance (HP:0010982)1.95271081
108Abnormality of fatty-acid metabolism (HP:0004359)1.94117821
109Abnormality of vitamin B metabolism (HP:0004340)1.93679950
110Lactic acidosis (HP:0003128)1.93124810
111Hypoglycemic seizures (HP:0002173)1.92937363
112Abnormality of glycine metabolism (HP:0010895)1.92137498
113Abnormality of serine family amino acid metabolism (HP:0010894)1.92137498
114Increased intramyocellular lipid droplets (HP:0012240)1.91717714
115Pseudobulbar signs (HP:0002200)1.91406836
116Increased nuchal translucency (HP:0010880)1.91166990
117Muscle hypertrophy of the lower extremities (HP:0008968)1.90972619
118Mitochondrial inheritance (HP:0001427)1.90221415
119Bilateral microphthalmos (HP:0007633)1.89921201
120Carpal bone hypoplasia (HP:0001498)1.88797970
121Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.88627582
122Neoplasm of the colon (HP:0100273)1.88566697
123Hepatic necrosis (HP:0002605)1.88473790
124Progressive macrocephaly (HP:0004481)1.87380414
125Hypoplasia of the fovea (HP:0007750)1.87179620
126Aplasia/Hypoplasia of the fovea (HP:0008060)1.87179620
127Abnormality of glycolipid metabolism (HP:0010969)1.86954979
128Abnormality of liposaccharide metabolism (HP:0010968)1.86954979
129Abnormality of glycosphingolipid metabolism (HP:0004343)1.86954979
130Cortical dysplasia (HP:0002539)1.86763889
131Biliary tract neoplasm (HP:0100574)1.86706517
132Heart block (HP:0012722)1.86469568
133Aneurysm (HP:0002617)1.85826208
134Cerebral edema (HP:0002181)1.85781290
135Absent radius (HP:0003974)1.85532985
136Ragged-red muscle fibers (HP:0003200)1.85203766
137Rhabdomyosarcoma (HP:0002859)1.85043142
138Megaloblastic anemia (HP:0001889)1.85031552
139Vertebral arch anomaly (HP:0008438)1.84464135
140Exercise intolerance (HP:0003546)1.84120436
141Rimmed vacuoles (HP:0003805)1.83461009
142Xanthomatosis (HP:0000991)1.82969654
143Areflexia of lower limbs (HP:0002522)1.82863153
144Abnormality of proline metabolism (HP:0010907)1.82167911
145Hydroxyprolinuria (HP:0003080)1.82167911
146Absent eyebrow (HP:0002223)1.80847336
147Toxemia of pregnancy (HP:0100603)1.80731551
148Hamartoma of the eye (HP:0010568)1.80698638
149Neoplasm of the small intestine (HP:0100833)1.80007539
150Abnormal protein glycosylation (HP:0012346)1.79839929
151Abnormal glycosylation (HP:0012345)1.79839929
152Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.79839929
153Abnormal protein N-linked glycosylation (HP:0012347)1.79839929
154Global brain atrophy (HP:0002283)1.79260971
155Deep venous thrombosis (HP:0002625)1.78567243
156Hepatocellular necrosis (HP:0001404)1.78505870
157Abnormality of dicarboxylic acid metabolism (HP:0010995)1.78428964
158Dicarboxylic aciduria (HP:0003215)1.78428964
159Aplasia involving forearm bones (HP:0009822)1.78289352
160Absent forearm bone (HP:0003953)1.78289352
161Abnormality of the fovea (HP:0000493)1.78128960
162Reticulocytosis (HP:0001923)1.77489696
163Hypopigmentation of the fundus (HP:0007894)1.77410023
164Hyperinsulinemic hypoglycemia (HP:0000825)1.76910760
165Horseshoe kidney (HP:0000085)1.75615522
166Back pain (HP:0003418)1.75220119
167Breast carcinoma (HP:0003002)1.74938398
168Nemaline bodies (HP:0003798)1.74502341
169Ovarian neoplasm (HP:0100615)1.73975334
170Bronchitis (HP:0012387)1.73468404
171Progressive external ophthalmoplegia (HP:0000590)1.72491545
172Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.72478613
173Fatigue (HP:0012378)1.71966640
174Facial cleft (HP:0002006)1.71964583
175Dysostosis multiplex (HP:0000943)1.71848695
176Abnormal atrioventricular conduction (HP:0005150)1.71213709
177Urinary glycosaminoglycan excretion (HP:0003541)1.71118883
178Mucopolysacchariduria (HP:0008155)1.71118883
179Bladder diverticulum (HP:0000015)1.71053509
180Tetraplegia (HP:0002445)1.71034962
181Stenosis of the external auditory canal (HP:0000402)1.69317822
182Ventricular arrhythmia (HP:0004308)1.68191977
183Pheochromocytoma (HP:0002666)1.68024347
184Supernumerary spleens (HP:0009799)1.67941347
185Obsessive-compulsive behavior (HP:0000722)1.67718315
186Renal Fanconi syndrome (HP:0001994)1.67694779
187Proximal tubulopathy (HP:0000114)1.67386422
188Hemiplegia (HP:0002301)1.66479790
189Abnormality of purine metabolism (HP:0004352)1.65461231
190Resting tremor (HP:0002322)1.64273841
191Athetosis (HP:0002305)1.63574794

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.61213180
2PKN23.83140932
3TSSK63.45643052
4SRPK13.43296445
5EPHA33.38341394
6PDK43.31185990
7PDK33.31185990
8TTK2.88209346
9ZAK2.83914907
10MKNK22.83318441
11EIF2AK32.77834457
12CDC72.74842210
13PBK2.72747310
14EEF2K2.71218743
15MKNK12.56949788
16MAP3K102.55596997
17RIPK12.48034320
18NEK12.46946894
19MST42.43075601
20ERN12.36074514
21PLK32.29277660
22BRSK22.21711534
23PLK42.12265674
24TTN2.07560431
25TRIM282.06740217
26STK161.99004754
27EIF2AK11.88620839
28WEE11.87961630
29MAPKAPK31.87491921
30BCKDK1.85518985
31MAP4K21.72802803
32SCYL21.72531951
33NEK21.66721083
34MAP3K91.63381854
35OBSCN1.63303156
36ICK1.63249366
37VRK21.62784209
38LMTK21.61108969
39TAF11.58283691
40PLK11.54201491
41CAMK1D1.50897567
42CAMKK11.49245828
43NUAK11.42771586
44WNK31.42209830
45BCR1.41443171
46PRKD31.40044703
47CDK191.39113183
48PDK21.34611240
49MST1R1.31601687
50FLT31.28785632
51TESK11.28046736
52PTK61.26979085
53TNIK1.26186476
54TYK21.25787172
55SIK11.25530487
56TESK21.24990164
57TAOK11.24709896
58FGFR41.23925566
59MAP4K11.21950535
60BMPR1B1.16165187
61ZAP701.15626018
62BRD41.15321708
63OXSR11.08680387
64PLK21.08613151
65FGFR21.07038056
66CAMK1G1.06469027
67CSNK1G11.04880409
68STK31.03938915
69ATR1.03527127
70RET1.00596602
71MAP3K70.97693788
72EIF2AK20.97074531
73MTOR0.97072096
74VRK10.96701115
75NME10.94535031
76DYRK1B0.93786941
77TBK10.93572031
78CHEK20.91221231
79LRRK20.89835727
80PAK60.89784331
81CDK40.86840099
82ERBB40.86256003
83PRKAA10.86066913
84STK38L0.85537175
85ATM0.83388496
86PINK10.83064592
87FGFR10.82275548
88STK380.80767501
89ERBB20.79500196
90KSR20.78860556
91MAP3K40.78336997
92MARK30.77779540
93CSNK1G30.76844681
94CDK60.76625647
95PDGFRA0.76377588
96CSNK1G20.74498736
97PHKG10.74433521
98PHKG20.74433521
99AURKB0.74199649
100WNK40.74162547
101MAPK110.73893010
102TLK10.73754028
103MAP2K30.73453833
104CASK0.71770006
105CHEK10.71715917
106ERBB30.70998562
107FGFR30.69810192
108CDK120.69164485
109PASK0.66876188
110CSNK1A1L0.66629811
111PNCK0.64335171
112JAK10.63775237
113DYRK20.63291089
114DMPK0.62520334
115GRK10.59776129
116BMX0.59697994
117RPS6KA20.59384273
118CAMKK20.59050668
119CSNK1E0.58030087
120PDK10.58003283
121STK100.57437446
122STK390.55444345
123KDR0.54684328
124ALK0.54405841
125PRKCI0.52924440
126INSRR0.52629850
127DAPK20.52575877
128AKT20.52266165
129PAK30.52241574
130STK240.51481599
131RPS6KB20.50488957
132JAK20.50275772
133MINK10.49687488
134PRKAA20.49186964
135HCK0.48943670
136CSNK2A20.47484483
137LATS10.47196666
138CSNK2A10.46505266
139IRAK20.46223142
140CDK10.45133993
141ITK0.43847907
142PDGFRB0.43835209
143KSR10.43101802
144TGFBR10.42919686
145BRSK10.42411337
146RPS6KA10.42303124
147AURKA0.41788432
148GRK60.41214245
149DYRK30.41055833
150TAOK20.40944026
151CDK70.40888717
152NLK0.40134964
153PRKDC0.40014763
154SGK30.39796485
155PRKCG0.39188636
156MUSK0.38454249
157CDK20.37994833
158PRKCE0.37774552
159STK40.36469674
160ILK0.35044781
161BTK0.34735688
162PDPK10.34691458
163BUB10.34407716
164MAP3K80.34143332
165MAP2K70.33359497
166ACVR1B0.33130054
167FRK0.32838675
168TRPM70.32662857
169MAP3K50.32658267
170RPS6KA40.32128524
171PRKD10.31341585
172PRKCH0.31324164
173CSNK1A10.31263477
174MAP3K110.30966055
175DAPK30.30216516
176PIM10.29653622
177CSNK1D0.25466204

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.17069748
2Nitrogen metabolism_Homo sapiens_hsa009103.36495496
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.99340457
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.93865980
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.84706227
6Proteasome_Homo sapiens_hsa030502.76894154
7Mismatch repair_Homo sapiens_hsa034302.71717575
8DNA replication_Homo sapiens_hsa030302.69768377
9Non-homologous end-joining_Homo sapiens_hsa034502.69384680
10Fatty acid degradation_Homo sapiens_hsa000712.47069869
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.46101563
12Carbon metabolism_Homo sapiens_hsa012002.45689326
13Selenocompound metabolism_Homo sapiens_hsa004502.35783621
14Propanoate metabolism_Homo sapiens_hsa006402.30901774
15RNA transport_Homo sapiens_hsa030132.27373661
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.21955687
17One carbon pool by folate_Homo sapiens_hsa006702.20446101
18Homologous recombination_Homo sapiens_hsa034402.17323828
19RNA polymerase_Homo sapiens_hsa030202.12375333
20Protein export_Homo sapiens_hsa030602.08041394
21Pentose phosphate pathway_Homo sapiens_hsa000302.00992738
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.00943188
23Arginine biosynthesis_Homo sapiens_hsa002201.96976744
24Biosynthesis of amino acids_Homo sapiens_hsa012301.91248205
25Fatty acid metabolism_Homo sapiens_hsa012121.85527275
26Pyruvate metabolism_Homo sapiens_hsa006201.83072913
27Basal transcription factors_Homo sapiens_hsa030221.83054770
28Spliceosome_Homo sapiens_hsa030401.81653444
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.81173313
30Base excision repair_Homo sapiens_hsa034101.80843050
31Steroid biosynthesis_Homo sapiens_hsa001001.76136705
32RNA degradation_Homo sapiens_hsa030181.75878831
33Nucleotide excision repair_Homo sapiens_hsa034201.67684034
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.65885831
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.57883096
36Lysine degradation_Homo sapiens_hsa003101.56120131
37Cell cycle_Homo sapiens_hsa041101.55373698
38Oxidative phosphorylation_Homo sapiens_hsa001901.52799788
39PPAR signaling pathway_Homo sapiens_hsa033201.49195804
40Fatty acid elongation_Homo sapiens_hsa000621.44845292
41Fanconi anemia pathway_Homo sapiens_hsa034601.44774181
42Parkinsons disease_Homo sapiens_hsa050121.42921787
43Fatty acid biosynthesis_Homo sapiens_hsa000611.42349960
44Glycerolipid metabolism_Homo sapiens_hsa005611.41398564
45Carbohydrate digestion and absorption_Homo sapiens_hsa049731.41257587
46Bile secretion_Homo sapiens_hsa049761.39275516
47mRNA surveillance pathway_Homo sapiens_hsa030151.37612190
48Insulin resistance_Homo sapiens_hsa049311.33845861
49Central carbon metabolism in cancer_Homo sapiens_hsa052301.32080578
50Glucagon signaling pathway_Homo sapiens_hsa049221.31508148
51Adipocytokine signaling pathway_Homo sapiens_hsa049201.30791128
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.26954697
53Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.25650344
54Butanoate metabolism_Homo sapiens_hsa006501.24597028
55Pyrimidine metabolism_Homo sapiens_hsa002401.24424686
56Fat digestion and absorption_Homo sapiens_hsa049751.24241253
57Purine metabolism_Homo sapiens_hsa002301.21507712
58Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.21250364
59AMPK signaling pathway_Homo sapiens_hsa041521.20762290
60Insulin signaling pathway_Homo sapiens_hsa049101.19999831
61Folate biosynthesis_Homo sapiens_hsa007901.17095296
62Arginine and proline metabolism_Homo sapiens_hsa003301.16969984
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.14625079
64Ribosome_Homo sapiens_hsa030101.14252961
65Fructose and mannose metabolism_Homo sapiens_hsa000511.12276649
66Tryptophan metabolism_Homo sapiens_hsa003801.11685068
67Primary bile acid biosynthesis_Homo sapiens_hsa001201.09180135
68Type II diabetes mellitus_Homo sapiens_hsa049301.06366216
69mTOR signaling pathway_Homo sapiens_hsa041501.06098432
70Huntingtons disease_Homo sapiens_hsa050161.04307343
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95318770
72Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.91596526
73ABC transporters_Homo sapiens_hsa020100.90788213
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90162034
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.87240974
76Longevity regulating pathway - mammal_Homo sapiens_hsa042110.86793993
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85137640
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85118376
79Inositol phosphate metabolism_Homo sapiens_hsa005620.84253948
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83660518
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83225994
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.82481906
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79292028
84Chronic myeloid leukemia_Homo sapiens_hsa052200.78992153
85Dilated cardiomyopathy_Homo sapiens_hsa054140.78866135
86VEGF signaling pathway_Homo sapiens_hsa043700.78855154
87Metabolic pathways_Homo sapiens_hsa011000.76953394
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76791010
89Starch and sucrose metabolism_Homo sapiens_hsa005000.75616743
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.75110081
91Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.73305547
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.72728358
93p53 signaling pathway_Homo sapiens_hsa041150.71584345
94Glutathione metabolism_Homo sapiens_hsa004800.69906575
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69172732
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.69032445
97Gastric acid secretion_Homo sapiens_hsa049710.68700448
98Pancreatic secretion_Homo sapiens_hsa049720.68453613
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.68322343
100Maturity onset diabetes of the young_Homo sapiens_hsa049500.67868840
101Alzheimers disease_Homo sapiens_hsa050100.67101370
102N-Glycan biosynthesis_Homo sapiens_hsa005100.63022300
103Non-small cell lung cancer_Homo sapiens_hsa052230.62332206
104Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.61258373
105Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61249599
106Galactose metabolism_Homo sapiens_hsa000520.60899205
107B cell receptor signaling pathway_Homo sapiens_hsa046620.60852866
108Vitamin digestion and absorption_Homo sapiens_hsa049770.60063142
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.59643690
110T cell receptor signaling pathway_Homo sapiens_hsa046600.58764596
111Endometrial cancer_Homo sapiens_hsa052130.53860927
112Insulin secretion_Homo sapiens_hsa049110.52813349
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52618672
114Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52257741
115Cyanoamino acid metabolism_Homo sapiens_hsa004600.51276687
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49389082
117Phototransduction_Homo sapiens_hsa047440.49199604
118Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49149832
119Glioma_Homo sapiens_hsa052140.48135921
120Peroxisome_Homo sapiens_hsa041460.47957614
121Viral myocarditis_Homo sapiens_hsa054160.46403170
122Renin-angiotensin system_Homo sapiens_hsa046140.45872367
123Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44353213
124Cardiac muscle contraction_Homo sapiens_hsa042600.44254642
125Aldosterone synthesis and secretion_Homo sapiens_hsa049250.44153539
126Regulation of autophagy_Homo sapiens_hsa041400.44009224
127Acute myeloid leukemia_Homo sapiens_hsa052210.43825701
128HIF-1 signaling pathway_Homo sapiens_hsa040660.43824413
129Endocytosis_Homo sapiens_hsa041440.42525795
130cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40932057
131beta-Alanine metabolism_Homo sapiens_hsa004100.40266501
132Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39786484
133Circadian rhythm_Homo sapiens_hsa047100.39433711
134Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.39295339
135Hippo signaling pathway_Homo sapiens_hsa043900.38814136
136Primary immunodeficiency_Homo sapiens_hsa053400.38775363
137Oocyte meiosis_Homo sapiens_hsa041140.37949822
138Sulfur metabolism_Homo sapiens_hsa009200.37945928
139TGF-beta signaling pathway_Homo sapiens_hsa043500.36463617
140Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35916481
141Tight junction_Homo sapiens_hsa045300.34865417
142Dorso-ventral axis formation_Homo sapiens_hsa043200.34817453
143Bladder cancer_Homo sapiens_hsa052190.34030591
144Antigen processing and presentation_Homo sapiens_hsa046120.32945687
145Sulfur relay system_Homo sapiens_hsa041220.32867940
146Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32831338
147Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32435006
148Proteoglycans in cancer_Homo sapiens_hsa052050.30980985
149Vitamin B6 metabolism_Homo sapiens_hsa007500.30672112
150Small cell lung cancer_Homo sapiens_hsa052220.28827427
151Thyroid hormone synthesis_Homo sapiens_hsa049180.28603618
152Tyrosine metabolism_Homo sapiens_hsa003500.27835173
153Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26970471
154Phospholipase D signaling pathway_Homo sapiens_hsa040720.26588642
155Ether lipid metabolism_Homo sapiens_hsa005650.25669938
156Retinol metabolism_Homo sapiens_hsa008300.25317815
157Thyroid cancer_Homo sapiens_hsa052160.24247544
158Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24059624
159Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23875288
160Wnt signaling pathway_Homo sapiens_hsa043100.20253576
161Sphingolipid metabolism_Homo sapiens_hsa006000.20231588

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