MRTO4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein sharing a low level of sequence similarity with ribosomal protein P0. While the precise function of the encoded protein is currently unknown, it appears to be involved in mRNA turnover and ribosome assembly. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.94172252
2nucleobase biosynthetic process (GO:0046112)4.89615930
3formation of translation preinitiation complex (GO:0001731)4.79225069
4DNA strand elongation involved in DNA replication (GO:0006271)4.72088221
5purine nucleobase biosynthetic process (GO:0009113)4.71932857
6DNA replication initiation (GO:0006270)4.61612245
7ribosome assembly (GO:0042255)4.51541685
8DNA strand elongation (GO:0022616)4.49830592
9maturation of SSU-rRNA (GO:0030490)4.45666738
10telomere maintenance via semi-conservative replication (GO:0032201)4.42152407
11DNA replication checkpoint (GO:0000076)4.38714591
12* ribosome biogenesis (GO:0042254)4.30041480
13ribosomal small subunit assembly (GO:0000028)4.19267359
14protein localization to kinetochore (GO:0034501)4.12203407
15mitotic metaphase plate congression (GO:0007080)4.08719024
16DNA unwinding involved in DNA replication (GO:0006268)4.06294226
17establishment of protein localization to mitochondrial membrane (GO:0090151)4.02041151
18* ribonucleoprotein complex biogenesis (GO:0022613)4.00620694
19IMP biosynthetic process (GO:0006188)4.00225146
20ribosomal large subunit biogenesis (GO:0042273)3.96650224
21telomere maintenance via recombination (GO:0000722)3.89987692
22folic acid-containing compound biosynthetic process (GO:0009396)3.89456477
23proteasome assembly (GO:0043248)3.87243085
24spliceosomal snRNP assembly (GO:0000387)3.86099596
25mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.83695562
26regulation of mitochondrial translation (GO:0070129)3.83160345
27mitotic nuclear envelope disassembly (GO:0007077)3.82820258
28nucleobase-containing small molecule interconversion (GO:0015949)3.81358898
29DNA replication-dependent nucleosome organization (GO:0034723)3.80635559
30DNA replication-dependent nucleosome assembly (GO:0006335)3.80635559
31rRNA modification (GO:0000154)3.78146159
32rRNA processing (GO:0006364)3.77580206
33pseudouridine synthesis (GO:0001522)3.74697176
34regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.71606247
35CENP-A containing nucleosome assembly (GO:0034080)3.69672641
36regulation of translational fidelity (GO:0006450)3.69258796
37mitotic recombination (GO:0006312)3.64989703
38rRNA metabolic process (GO:0016072)3.64967407
39chromatin remodeling at centromere (GO:0031055)3.63685526
40nuclear pore organization (GO:0006999)3.59075294
41viral transcription (GO:0019083)3.58951366
42translational termination (GO:0006415)3.57859073
43telomere maintenance via telomere lengthening (GO:0010833)3.56689476
44chaperone-mediated protein transport (GO:0072321)3.56643301
45ribosomal small subunit biogenesis (GO:0042274)3.56344534
46establishment of viral latency (GO:0019043)3.56056587
47translational initiation (GO:0006413)3.55305350
48IMP metabolic process (GO:0046040)3.55081162
49protein localization to chromosome, centromeric region (GO:0071459)3.52893475
50nuclear envelope disassembly (GO:0051081)3.51641508
51membrane disassembly (GO:0030397)3.51641508
52negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.50888706
53mitotic chromosome condensation (GO:0007076)3.50511963
54anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.49498788
55protein targeting to ER (GO:0045047)3.49057212
56regulation of translational termination (GO:0006449)3.47918499
57transcription from mitochondrial promoter (GO:0006390)3.46531611
58folic acid metabolic process (GO:0046655)3.44470878
59regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.44325161
60DNA replication-independent nucleosome organization (GO:0034724)3.41448382
61DNA replication-independent nucleosome assembly (GO:0006336)3.41448382
62positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.39839461
63protein targeting to mitochondrion (GO:0006626)3.38665436
64translational elongation (GO:0006414)3.37080038
65metaphase plate congression (GO:0051310)3.35468533
66establishment of protein localization to endoplasmic reticulum (GO:0072599)3.34131495
67energy coupled proton transport, down electrochemical gradient (GO:0015985)3.30803327
68ATP synthesis coupled proton transport (GO:0015986)3.30803327
69nucleotide-excision repair, DNA gap filling (GO:0006297)3.30000228
70termination of RNA polymerase III transcription (GO:0006386)3.29169083
71transcription elongation from RNA polymerase III promoter (GO:0006385)3.29169083
72tRNA aminoacylation for protein translation (GO:0006418)3.28694869
73transcription-coupled nucleotide-excision repair (GO:0006283)3.28439917
74mitochondrial RNA metabolic process (GO:0000959)3.27974665
75protein localization to endoplasmic reticulum (GO:0070972)3.27439204
76tRNA aminoacylation (GO:0043039)3.27181081
77amino acid activation (GO:0043038)3.27181081
78pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.26602316
79nuclear pore complex assembly (GO:0051292)3.25950040
80sister chromatid segregation (GO:0000819)3.25875312
81spliceosomal complex assembly (GO:0000245)3.21204802
82negative regulation of ligase activity (GO:0051352)3.20427062
83negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.20427062
84negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.18514805
85G1/S transition of mitotic cell cycle (GO:0000082)3.18106726
86cell cycle G1/S phase transition (GO:0044843)3.18106726
87histone exchange (GO:0043486)3.16647748
88establishment of protein localization to mitochondrion (GO:0072655)3.15245172
89viral mRNA export from host cell nucleus (GO:0046784)3.14799462
90maturation of 5.8S rRNA (GO:0000460)3.14425865
91regulation of nuclear cell cycle DNA replication (GO:0033262)3.13408235
92nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.13246574
93viral life cycle (GO:0019058)3.10420227
94pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.09811004
95kinetochore organization (GO:0051383)3.08911048
96termination of RNA polymerase I transcription (GO:0006363)3.07906441
97transcription from RNA polymerase I promoter (GO:0006360)3.07294551
98positive regulation of ligase activity (GO:0051351)3.06653776
99pteridine-containing compound biosynthetic process (GO:0042559)3.06196472
100cellular protein complex disassembly (GO:0043624)3.05131745
101regulation of spindle organization (GO:0090224)3.04336378
102deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.04064619
103positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.03853662
104protein localization to mitochondrion (GO:0070585)3.03726419
105* cellular component biogenesis (GO:0044085)3.03534578
106translation (GO:0006412)3.03458631
1077-methylguanosine mRNA capping (GO:0006370)3.03216116
108transcription elongation from RNA polymerase I promoter (GO:0006362)3.03107554
109regulation of ubiquitin-protein transferase activity (GO:0051438)3.02442439
110regulation of cellular amino acid metabolic process (GO:0006521)3.02153934
111mitotic sister chromatid segregation (GO:0000070)3.01996986
112DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.01643391
113kinetochore assembly (GO:0051382)3.00864157
114SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.00041825
115establishment of chromosome localization (GO:0051303)2.99176337
116signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.97802468
117signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.97802468
118signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.97802468
119signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.97424009
120intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.97424009
121signal transduction involved in DNA damage checkpoint (GO:0072422)2.96746101
122signal transduction involved in DNA integrity checkpoint (GO:0072401)2.96746101
123RNA capping (GO:0036260)2.96220814
1247-methylguanosine RNA capping (GO:0009452)2.96220814
125regulation of double-strand break repair via homologous recombination (GO:0010569)2.96167991
126establishment of integrated proviral latency (GO:0075713)2.95691694
127rRNA methylation (GO:0031167)2.95405748
128attachment of spindle microtubules to kinetochore (GO:0008608)2.93626808
129signal transduction involved in cell cycle checkpoint (GO:0072395)2.92503898
130ncRNA processing (GO:0034470)2.91897313
131RNA splicing, via transesterification reactions (GO:0000375)2.90524972
132cotranslational protein targeting to membrane (GO:0006613)2.89524838

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.74307569
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.56174392
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.94137547
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.39303095
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.36533749
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.32281231
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.17735772
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.16294567
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.14777114
10* ETS1_20019798_ChIP-Seq_JURKAT_Human3.06894453
11MYC_18358816_ChIP-ChIP_MESCs_Mouse3.06042646
12GABP_17652178_ChIP-ChIP_JURKAT_Human3.04696804
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.98950601
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.86499858
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.81303046
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.62464334
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.48095512
18XRN2_22483619_ChIP-Seq_HELA_Human2.42957894
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.36034877
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.31901101
21* VDR_23849224_ChIP-Seq_CD4+_Human2.30333438
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.25213717
23E2F1_18555785_ChIP-Seq_MESCs_Mouse2.08725100
24* DCP1A_22483619_ChIP-Seq_HELA_Human2.03225646
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.01757276
26FOXP3_21729870_ChIP-Seq_TREG_Human2.01496023
27GABP_19822575_ChIP-Seq_HepG2_Human2.01191585
28AR_21909140_ChIP-Seq_LNCAP_Human1.99920421
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.93466188
30THAP11_20581084_ChIP-Seq_MESCs_Mouse1.92422528
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.91389188
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.89887652
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.87873678
34TTF2_22483619_ChIP-Seq_HELA_Human1.86860505
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.83257400
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.82133631
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.81201220
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.79616514
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74793868
40* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.64286903
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59883931
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.56689482
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.56457765
44ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55881604
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.53913850
46CIITA_25753668_ChIP-Seq_RAJI_Human1.53761662
47ELK1_19687146_ChIP-ChIP_HELA_Human1.51179464
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.50846366
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.50786639
50KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.50423731
51* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.50179390
52* KDM5A_27292631_Chip-Seq_BREAST_Human1.46130269
53MYC_22102868_ChIP-Seq_BL_Human1.45930454
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.37071036
55STAT3_1855785_ChIP-Seq_MESCs_Mouse1.36344320
56POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.36241274
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34321695
58ZNF263_19887448_ChIP-Seq_K562_Human1.32576473
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.30504662
60CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29640333
61SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.27768459
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26725827
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25153150
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24385433
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22587342
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.19580303
67DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16563483
68PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.15885599
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13321118
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11309264
71TP63_19390658_ChIP-ChIP_HaCaT_Human1.11041225
72* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10659384
73* NOTCH1_21737748_ChIP-Seq_TLL_Human1.10633518
74TFEB_21752829_ChIP-Seq_HELA_Human1.09666736
75ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.08718103
76CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08226797
77TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.07815020
78KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06578319
79ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05995884
80SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05945050
81BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04435303
82CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01394945
83CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00141662
84KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99581483
85* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98254381
86CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97962467
87DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.96956543
88ELK1_22589737_ChIP-Seq_MCF10A_Human0.96776649
89PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.95113374
90SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.92696288
91MYC_18940864_ChIP-ChIP_HL60_Human0.92324896
92TBX5_21415370_ChIP-Seq_HL-1_Mouse0.90834847
93CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88816379
94SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.87096300
95SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.86096845
96HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.85671777
97FOXP1_21924763_ChIP-Seq_HESCs_Human0.85408706
98CTCF_18555785_ChIP-Seq_MESCs_Mouse0.84029853
99OCT4_18692474_ChIP-Seq_MEFs_Mouse0.83192493
100TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83172530
101GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83071461
102TCF3_18692474_ChIP-Seq_MEFs_Mouse0.82564052
103SPI1_23547873_ChIP-Seq_NB4_Human0.82205580
104HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.82033087
105NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.81037848
106VDR_21846776_ChIP-Seq_THP-1_Human0.80995751
107SOX17_20123909_ChIP-Seq_XEN_Mouse0.80771230
108CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.80176271
109NANOG_21062744_ChIP-ChIP_HESCs_Human0.80078539
110CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.79587196
111ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.79339965
112SOX2_18692474_ChIP-Seq_MEFs_Mouse0.79021785
113TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.78582590
114RBPJ_22232070_ChIP-Seq_NCS_Mouse0.78262254

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.07344095
2MP0004957_abnormal_blastocyst_morpholog4.84712163
3MP0003111_abnormal_nucleus_morphology4.83466189
4MP0010094_abnormal_chromosome_stability4.62574026
5MP0003077_abnormal_cell_cycle4.16510912
6MP0008057_abnormal_DNA_replication3.92860950
7MP0008058_abnormal_DNA_repair3.57503940
8MP0008007_abnormal_cellular_replicative2.86530368
9MP0008932_abnormal_embryonic_tissue2.82952819
10MP0001730_embryonic_growth_arrest2.55117792
11MP0003123_paternal_imprinting2.49933720
12MP0002396_abnormal_hematopoietic_system2.35905534
13MP0000350_abnormal_cell_proliferation2.29425295
14MP0003786_premature_aging2.24506267
15MP0010352_gastrointestinal_tract_polyps2.10020368
16MP0003718_maternal_effect2.08964017
17MP0008877_abnormal_DNA_methylation2.05742408
18MP0009379_abnormal_foot_pigmentation2.03864010
19MP0003806_abnormal_nucleotide_metabolis1.96113681
20MP0001672_abnormal_embryogenesis/_devel1.85674661
21MP0005380_embryogenesis_phenotype1.85674661
22MP0009697_abnormal_copulation1.78642590
23MP0002877_abnormal_melanocyte_morpholog1.75046080
24MP0001697_abnormal_embryo_size1.72462698
25MP0002080_prenatal_lethality1.69328686
26MP0003984_embryonic_growth_retardation1.66503993
27MP0000490_abnormal_crypts_of1.63418302
28MP0002088_abnormal_embryonic_growth/wei1.62163641
29MP0010307_abnormal_tumor_latency1.60405049
30MP0009333_abnormal_splenocyte_physiolog1.55412586
31MP0000313_abnormal_cell_death1.55237252
32MP0002085_abnormal_embryonic_tissue1.51656118
33MP0002938_white_spotting1.42519888
34MP0002019_abnormal_tumor_incidence1.41119971
35MP0002086_abnormal_extraembryonic_tissu1.35374665
36MP0005397_hematopoietic_system_phenotyp1.35260936
37MP0001545_abnormal_hematopoietic_system1.35260936
38MP0002084_abnormal_developmental_patter1.34161562
39MP0010030_abnormal_orbit_morphology1.32525144
40MP0002210_abnormal_sex_determination1.31498993
41MP0003890_abnormal_embryonic-extraembry1.31464646
42MP0004197_abnormal_fetal_growth/weight/1.31087456
43MP0003567_abnormal_fetal_cardiomyocyte1.27460880
44MP0001293_anophthalmia1.26245326
45MP0003186_abnormal_redox_activity1.26059751
46MP0005501_abnormal_skin_physiology1.25879706
47MP0004808_abnormal_hematopoietic_stem1.25731329
48MP0001346_abnormal_lacrimal_gland1.24388094
49MP0002132_abnormal_respiratory_system1.19755058
50MP0003315_abnormal_perineum_morphology1.18877404
51MP0005257_abnormal_intraocular_pressure1.17856598
52MP0001145_abnormal_male_reproductive1.16171653
53MP0006292_abnormal_olfactory_placode1.15451436
54MP0002160_abnormal_reproductive_system1.15449877
55MP0000358_abnormal_cell_content/1.14296668
56MP0004233_abnormal_muscle_weight1.09176194
57MP0008789_abnormal_olfactory_epithelium1.09023305
58MP0002163_abnormal_gland_morphology1.06633628
59MP0001929_abnormal_gametogenesis1.05661330
60MP0006035_abnormal_mitochondrial_morpho1.04955858
61MP0004185_abnormal_adipocyte_glucose1.00201186
62MP0001881_abnormal_mammary_gland0.99219340
63MP0001853_heart_inflammation0.96630080
64MP0000703_abnormal_thymus_morphology0.96498486
65MP0000653_abnormal_sex_gland0.95545740
66MP0003221_abnormal_cardiomyocyte_apopto0.95202755
67MP0009672_abnormal_birth_weight0.95165266
68MP0002722_abnormal_immune_system0.94459285
69MP0002697_abnormal_eye_size0.93118368
70MP0006036_abnormal_mitochondrial_physio0.91977762
71MP0003121_genomic_imprinting0.91809175
72MP0003763_abnormal_thymus_physiology0.91565785
73MP0000678_abnormal_parathyroid_gland0.90364196
74MP0000689_abnormal_spleen_morphology0.90214685
75MP0002398_abnormal_bone_marrow0.89749609
76MP0002653_abnormal_ependyma_morphology0.89553538
77MP0005389_reproductive_system_phenotype0.88373743
78MP0001529_abnormal_vocalization0.86970780
79MP0000858_altered_metastatic_potential0.85101445
80MP0004133_heterotaxia0.84172066
81MP0005384_cellular_phenotype0.84162909
82MP0000750_abnormal_muscle_regeneration0.83709015
83MP0003119_abnormal_digestive_system0.83383597
84MP0001661_extended_life_span0.80368735
85MP0008260_abnormal_autophagy0.80086607
86MP0002796_impaired_skin_barrier0.80052455
87MP0002111_abnormal_tail_morphology0.79883891
88MP0005075_abnormal_melanosome_morpholog0.79484128
89MP0009053_abnormal_anal_canal0.79056491
90MP0000049_abnormal_middle_ear0.77789279
91MP0001119_abnormal_female_reproductive0.77549336
92MP0005451_abnormal_body_composition0.75676904
93MP0002429_abnormal_blood_cell0.74763823
94MP0005621_abnormal_cell_physiology0.73937935
95MP0002234_abnormal_pharynx_morphology0.73846330
96MP0005076_abnormal_cell_differentiation0.70742292
97MP0005408_hypopigmentation0.69413966
98MP0005266_abnormal_metabolism0.68247458
99MP0005394_taste/olfaction_phenotype0.67126918
100MP0005499_abnormal_olfactory_system0.67126918
101MP0005023_abnormal_wound_healing0.66866741
102MP0000537_abnormal_urethra_morphology0.65180992
103MP0000372_irregular_coat_pigmentation0.63655719
104MP0009703_decreased_birth_body0.63248430
105MP0005623_abnormal_meninges_morphology0.63115008
106MP0003656_abnormal_erythrocyte_physiolo0.59479045
107MP0001216_abnormal_epidermal_layer0.58496617
108MP0001919_abnormal_reproductive_system0.58149050
109MP0002092_abnormal_eye_morphology0.57995340
110MP0002177_abnormal_outer_ear0.57479342
111MP0000627_abnormal_mammary_gland0.57424778
112MP0000428_abnormal_craniofacial_morphol0.56780902
113MP0005330_cardiomyopathy0.54987435
114MP0000716_abnormal_immune_system0.54800010
115MP0003937_abnormal_limbs/digits/tail_de0.54606930
116MP0001915_intracranial_hemorrhage0.54588665
117MP0003698_abnormal_male_reproductive0.54577877
118MP0000762_abnormal_tongue_morphology0.54528318
119MP0001873_stomach_inflammation0.54248444
120MP0000477_abnormal_intestine_morphology0.54004379
121MP0000579_abnormal_nail_morphology0.53709229
122MP0009278_abnormal_bone_marrow0.53538062
123MP0001764_abnormal_homeostasis0.53091070
124MP0005395_other_phenotype0.52982788
125MP0003941_abnormal_skin_development0.52678633
126MP0000647_abnormal_sebaceous_gland0.52629110
127MP0003385_abnormal_body_wall0.52473913
128MP0001727_abnormal_embryo_implantation0.52187957
129MP0002161_abnormal_fertility/fecundity0.52094023
130MP0002089_abnormal_postnatal_growth/wei0.52044489
131MP0001286_abnormal_eye_development0.50863729
132MP0002269_muscular_atrophy0.50346885
133MP0004147_increased_porphyrin_level0.50123466
134MP0008770_decreased_survivor_rate0.48297643
135MP0003699_abnormal_female_reproductive0.48241707

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.58283140
2Breast hypoplasia (HP:0003187)4.45826392
3Abnormality of cells of the erythroid lineage (HP:0012130)4.35862011
4Abnormal number of erythroid precursors (HP:0012131)4.22565661
5Reticulocytopenia (HP:0001896)4.16419848
6Acute necrotizing encephalopathy (HP:0006965)4.02063002
7Oral leukoplakia (HP:0002745)4.00565405
8Abnormal mitochondria in muscle tissue (HP:0008316)3.97917374
9Rough bone trabeculation (HP:0100670)3.71744647
10Degeneration of anterior horn cells (HP:0002398)3.69872975
11Abnormality of the anterior horn cell (HP:0006802)3.69872975
12Acute encephalopathy (HP:0006846)3.64790897
13Cerebral hypomyelination (HP:0006808)3.63373316
14Carpal bone hypoplasia (HP:0001498)3.62357657
15Selective tooth agenesis (HP:0001592)3.56879953
16Patellar aplasia (HP:0006443)3.52876117
17Increased CSF lactate (HP:0002490)3.47844252
18Chromsome breakage (HP:0040012)3.43318681
19Chromosomal breakage induced by crosslinking agents (HP:0003221)3.40230280
20Increased hepatocellular lipid droplets (HP:0006565)3.38794765
21Mitochondrial inheritance (HP:0001427)3.36635430
22Aplasia/Hypoplasia of the patella (HP:0006498)3.34993016
23Multiple enchondromatosis (HP:0005701)3.31033232
24Meckel diverticulum (HP:0002245)3.18310336
25Aplastic anemia (HP:0001915)3.13369543
26Absent thumb (HP:0009777)3.08201894
27Lipid accumulation in hepatocytes (HP:0006561)3.08184829
28Trismus (HP:0000211)3.07378321
29Microretrognathia (HP:0000308)3.06222819
30Abnormality of the preputium (HP:0100587)3.06119080
31Hepatocellular necrosis (HP:0001404)3.05242156
32Abnormality of the ileum (HP:0001549)3.02460966
33Progressive macrocephaly (HP:0004481)3.02139125
34Macrocytic anemia (HP:0001972)2.99724920
35Impulsivity (HP:0100710)2.99178414
36Colon cancer (HP:0003003)2.97641106
37Cerebral edema (HP:0002181)2.93003932
38Abnormality of chromosome stability (HP:0003220)2.80576866
39Pallor (HP:0000980)2.80267043
40Aplasia/Hypoplasia of the uvula (HP:0010293)2.79262525
41Increased intramyocellular lipid droplets (HP:0012240)2.76190719
42Premature graying of hair (HP:0002216)2.74548489
43Hepatic necrosis (HP:0002605)2.73880999
44Absent radius (HP:0003974)2.68435837
45Abnormal trabecular bone morphology (HP:0100671)2.66348930
46Premature ovarian failure (HP:0008209)2.65886306
47Ependymoma (HP:0002888)2.65174731
48Lactic acidosis (HP:0003128)2.62367332
49Bone marrow hypocellularity (HP:0005528)2.61882110
50Medulloblastoma (HP:0002885)2.61704021
51Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.60807726
52Exercise intolerance (HP:0003546)2.59414837
53Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.52462553
54Progressive muscle weakness (HP:0003323)2.50835566
55Duodenal stenosis (HP:0100867)2.50741160
56Small intestinal stenosis (HP:0012848)2.50741160
57Myelodysplasia (HP:0002863)2.49624890
58Aplasia involving forearm bones (HP:0009822)2.47703473
59Absent forearm bone (HP:0003953)2.47703473
60Secondary amenorrhea (HP:0000869)2.44156964
61Glossoptosis (HP:0000162)2.44150039
62Agnosia (HP:0010524)2.42231527
63Neoplasm of the pancreas (HP:0002894)2.40624248
64Cellular immunodeficiency (HP:0005374)2.36376999
65Horseshoe kidney (HP:0000085)2.36152245
66Renal Fanconi syndrome (HP:0001994)2.34691460
67Tracheoesophageal fistula (HP:0002575)2.31508903
68Increased muscle lipid content (HP:0009058)2.27924816
69Testicular atrophy (HP:0000029)2.27852189
70Cleft eyelid (HP:0000625)2.27683907
71Sparse eyelashes (HP:0000653)2.27402151
7211 pairs of ribs (HP:0000878)2.27252093
73Megaloblastic anemia (HP:0001889)2.27126033
74Rhabdomyosarcoma (HP:0002859)2.24986885
75Atresia of the external auditory canal (HP:0000413)2.23746367
76Reduced antithrombin III activity (HP:0001976)2.23149245
77Respiratory difficulties (HP:0002880)2.22952421
78Sloping forehead (HP:0000340)2.22059277
79Pancytopenia (HP:0001876)2.21920222
80Atrophy/Degeneration involving motor neurons (HP:0007373)2.21469170
81Hypoplasia of the pons (HP:0012110)2.20544104
82Spinal muscular atrophy (HP:0007269)2.20269269
83Abnormality of pyrimidine metabolism (HP:0004353)2.17503244
84Abnormal number of incisors (HP:0011064)2.17186908
85Ureteral duplication (HP:0000073)2.16239356
86Respiratory failure (HP:0002878)2.15920867
87Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.13931543
88Abnormal protein N-linked glycosylation (HP:0012347)2.13931543
89Abnormal protein glycosylation (HP:0012346)2.13931543
90Abnormal glycosylation (HP:0012345)2.13931543
91Triphalangeal thumb (HP:0001199)2.13430724
92Cholecystitis (HP:0001082)2.13011206
93Abnormal gallbladder physiology (HP:0012438)2.13011206
94CNS hypomyelination (HP:0003429)2.12927801
95Abnormality of the labia minora (HP:0012880)2.12031634
96Hypoplasia of the capital femoral epiphysis (HP:0003090)2.11847170
97Ragged-red muscle fibers (HP:0003200)2.09322479
98Microvesicular hepatic steatosis (HP:0001414)2.08746738
99Abnormal lung lobation (HP:0002101)2.08488602
100Abnormality of the pons (HP:0007361)2.07715423
101Aplasia/Hypoplasia of the sacrum (HP:0008517)2.06402989
102Increased serum lactate (HP:0002151)2.04940416
103Abnormality of the umbilical cord (HP:0010881)2.04742656
104Leukodystrophy (HP:0002415)2.03617010
1053-Methylglutaconic aciduria (HP:0003535)2.02342242
106Tongue fasciculations (HP:0001308)2.02071878
107Abnormality of the duodenum (HP:0002246)2.01523854
108Irregular epiphyses (HP:0010582)2.00336989
109Squamous cell carcinoma (HP:0002860)1.97756683
110Slender long bone (HP:0003100)1.95382848
111Supernumerary spleens (HP:0009799)1.94432530
112Ectopic kidney (HP:0000086)1.93954883
113Hypoplasia of the radius (HP:0002984)1.92495904
114Duplicated collecting system (HP:0000081)1.92442003
115Aplasia/hypoplasia of the humerus (HP:0006507)1.90887983
116Abnormality of reticulocytes (HP:0004312)1.89766340
117Progressive external ophthalmoplegia (HP:0000590)1.89750468
118Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.89596927
119Abnormality of alanine metabolism (HP:0010916)1.89596927
120Hyperalaninemia (HP:0003348)1.89596927
121Facial cleft (HP:0002006)1.89141902
122Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.88928026
123Abnormality of methionine metabolism (HP:0010901)1.88243749
124Basal cell carcinoma (HP:0002671)1.87663257
125Type I transferrin isoform profile (HP:0003642)1.86375799
126Amniotic constriction ring (HP:0009775)1.86276444
127Abnormality of placental membranes (HP:0011409)1.86276444
128Poor head control (HP:0002421)1.82271152
129Increased nuchal translucency (HP:0010880)1.81700150
130Personality changes (HP:0000751)1.80482204
131Thrombocytosis (HP:0001894)1.80254796
132Muscle fibrillation (HP:0010546)1.79523208
133Abnormality of the carotid arteries (HP:0005344)1.79275969
134Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.79021646
135Decreased activity of mitochondrial respiratory chain (HP:0008972)1.79021646
136Short thumb (HP:0009778)1.78379694
137Breast aplasia (HP:0100783)1.73271755
138Increased serum pyruvate (HP:0003542)1.73064268
139Abnormality of glycolysis (HP:0004366)1.73064268
140Entropion (HP:0000621)1.73044080
141Proximal placement of thumb (HP:0009623)1.72992883
142Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.72218702
143Postnatal microcephaly (HP:0005484)1.71728867
144Poikiloderma (HP:0001029)1.70959333

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.90943159
2WEE14.53644744
3VRK24.08130153
4EIF2AK13.79099626
5CDC73.60221693
6TSSK62.78937438
7NME22.62059466
8PLK42.50924011
9NEK22.48911741
10SRPK12.47489063
11STK162.35254597
12EIF2AK32.31145674
13TTK2.30131746
14NEK12.28137094
15TESK22.12526201
16BRSK21.97034670
17PLK11.96297030
18ACVR1B1.95782534
19VRK11.83283003
20SMG11.72029190
21CDK71.69699757
22MKNK11.66535856
23MST41.64502482
24EPHA21.63351245
25PLK31.55597068
26AURKB1.55529954
27DYRK31.54566707
28ATR1.51841247
29PIM21.51472220
30RPS6KA41.47088488
31RPS6KB21.45168274
32BRSK11.42156516
33TLK11.38264946
34MKNK21.37870791
35ZAK1.35121274
36MAP3K81.32262552
37CHEK21.32121196
38AURKA1.31167414
39PASK1.25357651
40CDK41.21817805
41CHEK11.17278611
42CDK121.16887542
43PAK41.15159593
44MAP3K111.09309039
45STK101.06401772
46CCNB11.05748275
47TAF11.00052403
48TESK10.97932590
49SCYL20.95073340
50EEF2K0.92488288
51PIM10.91308224
52TAOK20.90633036
53BRAF0.89156323
54MAP2K30.86726507
55ALK0.86684939
56EIF2AK20.83627327
57CLK10.81666773
58PAK10.79505014
59CDK20.78869022
60TGFBR10.78261847
61KDR0.77827234
62PDK30.76839669
63PDK40.76839669
64STK40.76291019
65CSNK2A20.75933915
66DAPK10.75749223
67ERBB40.72984409
68CSNK2A10.72255013
69PNCK0.70818390
70ATM0.69856864
71MAP4K10.67722735
72CDK80.64391777
73NME10.63471920
74BCKDK0.60279598
75MAP3K30.58114487
76MST1R0.58006684
77MAP3K100.57153678
78TRIB30.56279820
79ICK0.54264875
80TRIM280.53675449
81LRRK20.53022449
82MAPKAPK50.52855757
83CDK10.52811525
84PRKCI0.52651900
85NUAK10.50555501
86RPS6KA50.50256439
87MAPKAPK30.46642913
88IRAK30.46461339
89LATS20.45781995
90STK38L0.45566516
91CSNK1G30.43098528
92CSNK1E0.41650305
93AKT30.40884154
94PDK20.40294370
95BLK0.40044126
96ABL20.39420555
97AKT20.39384829
98BRD40.39193226
99GRK60.38418467
100MAP3K120.37976522
101DYRK20.37724638
102STK30.36902270
103ZAP700.36709146
104CDK11A0.35681747
105MELK0.33552688
106PBK0.32097251
107DAPK30.31173790
108MTOR0.30630674
109CDK150.29976094
110CDK60.29425201
111CDK180.29157564
112ARAF0.28819542
113CDK140.28063266
114CDK90.27840217
115ILK0.27312259
116FLT30.26544452
117MAP3K50.26543269
118CSNK1G10.25109348
119MAPK110.24110136
120LIMK10.24073899
121RAF10.19978041
122PRKDC0.19952523
123PAK20.18969309

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.80513398
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.14865854
3Mismatch repair_Homo sapiens_hsa034303.96421066
4Proteasome_Homo sapiens_hsa030503.92769796
5RNA polymerase_Homo sapiens_hsa030203.70845752
6Ribosome_Homo sapiens_hsa030103.61493506
7Spliceosome_Homo sapiens_hsa030403.32913110
8RNA transport_Homo sapiens_hsa030133.27924369
9Base excision repair_Homo sapiens_hsa034102.93895405
10Homologous recombination_Homo sapiens_hsa034402.82256822
11Nucleotide excision repair_Homo sapiens_hsa034202.77348616
12Pyrimidine metabolism_Homo sapiens_hsa002402.71632574
13One carbon pool by folate_Homo sapiens_hsa006702.71123827
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.56146638
15Cell cycle_Homo sapiens_hsa041102.41544988
16Fanconi anemia pathway_Homo sapiens_hsa034602.08639763
17Basal transcription factors_Homo sapiens_hsa030221.86186956
18RNA degradation_Homo sapiens_hsa030181.82587244
19Vitamin B6 metabolism_Homo sapiens_hsa007501.71829823
20mRNA surveillance pathway_Homo sapiens_hsa030151.57553774
21Non-homologous end-joining_Homo sapiens_hsa034501.53539945
22Purine metabolism_Homo sapiens_hsa002301.48731962
23p53 signaling pathway_Homo sapiens_hsa041151.46950833
24Alzheimers disease_Homo sapiens_hsa050101.26387507
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.23991126
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.23153848
27Epstein-Barr virus infection_Homo sapiens_hsa051691.22304429
28Folate biosynthesis_Homo sapiens_hsa007901.20649098
29Pentose phosphate pathway_Homo sapiens_hsa000301.18539290
30Pyruvate metabolism_Homo sapiens_hsa006201.14966731
31Biosynthesis of amino acids_Homo sapiens_hsa012301.12157668
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.99971351
33Drug metabolism - other enzymes_Homo sapiens_hsa009830.94379219
34Sulfur relay system_Homo sapiens_hsa041220.91821386
35Systemic lupus erythematosus_Homo sapiens_hsa053220.91541795
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88305506
37Selenocompound metabolism_Homo sapiens_hsa004500.79233945
38Steroid biosynthesis_Homo sapiens_hsa001000.79039836
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78813848
40Cyanoamino acid metabolism_Homo sapiens_hsa004600.78399608
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.76945172
42Antigen processing and presentation_Homo sapiens_hsa046120.75204702
43Herpes simplex infection_Homo sapiens_hsa051680.74825300
44Fatty acid elongation_Homo sapiens_hsa000620.74771814
45Viral carcinogenesis_Homo sapiens_hsa052030.73992451
46Oocyte meiosis_Homo sapiens_hsa041140.73815957
47Carbon metabolism_Homo sapiens_hsa012000.71096844
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.67480395
49Glutathione metabolism_Homo sapiens_hsa004800.66831711
50Fructose and mannose metabolism_Homo sapiens_hsa000510.66454185
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64814208
52Huntingtons disease_Homo sapiens_hsa050160.64289475
53Sulfur metabolism_Homo sapiens_hsa009200.62983324
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62978084
55Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60751498
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59017799
57Cardiac muscle contraction_Homo sapiens_hsa042600.57700846
58Legionellosis_Homo sapiens_hsa051340.55553009
59Protein export_Homo sapiens_hsa030600.53970886
60HTLV-I infection_Homo sapiens_hsa051660.53697986
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51821842
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49630778
63Thyroid cancer_Homo sapiens_hsa052160.48257937
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.46852285
65Parkinsons disease_Homo sapiens_hsa050120.46127163
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44442397
67Propanoate metabolism_Homo sapiens_hsa006400.41155512
68Galactose metabolism_Homo sapiens_hsa000520.38459369
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37697185
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.35036748
71Metabolic pathways_Homo sapiens_hsa011000.34845408
72Apoptosis_Homo sapiens_hsa042100.34443078
73Small cell lung cancer_Homo sapiens_hsa052220.33689242
74N-Glycan biosynthesis_Homo sapiens_hsa005100.33286120
75Regulation of autophagy_Homo sapiens_hsa041400.30257152
76MicroRNAs in cancer_Homo sapiens_hsa052060.29095296
77Arginine and proline metabolism_Homo sapiens_hsa003300.28601387
78Shigellosis_Homo sapiens_hsa051310.23616139
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.22995982
80Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.22880121
81Measles_Homo sapiens_hsa051620.22758849
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22749433
83Oxidative phosphorylation_Homo sapiens_hsa001900.21337079
84Primary immunodeficiency_Homo sapiens_hsa053400.21064182
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.20819656
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.19940818
87HIF-1 signaling pathway_Homo sapiens_hsa040660.19161534
88Arginine biosynthesis_Homo sapiens_hsa002200.19153404
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.17489484
90Arachidonic acid metabolism_Homo sapiens_hsa005900.17455719
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.15961889
92Hippo signaling pathway_Homo sapiens_hsa043900.15712010
93Renin-angiotensin system_Homo sapiens_hsa046140.15473621
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.15332195
95Hepatitis B_Homo sapiens_hsa051610.15008221
96Alcoholism_Homo sapiens_hsa050340.14838526
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.14768016
98TGF-beta signaling pathway_Homo sapiens_hsa043500.13902207
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.13358097
100Lysine degradation_Homo sapiens_hsa003100.12986905
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.12214835
102Asthma_Homo sapiens_hsa053100.12198037
103Bladder cancer_Homo sapiens_hsa052190.11866613
104Fatty acid metabolism_Homo sapiens_hsa012120.11443483
105Vibrio cholerae infection_Homo sapiens_hsa051100.11097208
106Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.10044272
107Influenza A_Homo sapiens_hsa051640.09509551
108NOD-like receptor signaling pathway_Homo sapiens_hsa046210.09365108
109Pentose and glucuronate interconversions_Homo sapiens_hsa000400.08967042
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.08890946
111Colorectal cancer_Homo sapiens_hsa052100.08653280
112RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.08451869
113Basal cell carcinoma_Homo sapiens_hsa052170.07349332
114Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.07148434
115Acute myeloid leukemia_Homo sapiens_hsa052210.07043266
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.06844573
117Intestinal immune network for IgA production_Homo sapiens_hsa046720.06318600
118Vitamin digestion and absorption_Homo sapiens_hsa049770.04322433
119Tyrosine metabolism_Homo sapiens_hsa003500.01830793
120Wnt signaling pathway_Homo sapiens_hsa04310-0.0167059
121Peroxisome_Homo sapiens_hsa04146-0.0015500

Most similar genes based on co-expression Upload to Enrichr

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