MRVI1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)4.70546804
2vascular endothelial growth factor signaling pathway (GO:0038084)4.44357838
3protein heterotrimerization (GO:0070208)4.23897431
4atrioventricular valve morphogenesis (GO:0003181)4.13701592
5glomerular filtration (GO:0003094)4.01276099
6extracellular matrix assembly (GO:0085029)3.99839610
7hypotonic response (GO:0006971)3.95302236
8apoptotic cell clearance (GO:0043277)3.92490769
9basement membrane organization (GO:0071711)3.89097701
10cell migration involved in heart development (GO:0060973)3.81691613
11renal filtration (GO:0097205)3.81018811
12retina vasculature morphogenesis in camera-type eye (GO:0061299)3.76140951
13negative regulation of cardiac muscle tissue growth (GO:0055022)3.68601724
14negative regulation of heart growth (GO:0061117)3.68601724
15myofibril assembly (GO:0030239)3.67939091
16regulation of skeletal muscle contraction (GO:0014819)3.66026823
17fibroblast migration (GO:0010761)3.64518883
18sarcomere organization (GO:0045214)3.62236240
19regulation of cardioblast differentiation (GO:0051890)3.51838083
20tonic smooth muscle contraction (GO:0014820)3.51391392
21muscle filament sliding (GO:0030049)3.48266153
22actin-myosin filament sliding (GO:0033275)3.48266153
23glomerular basement membrane development (GO:0032836)3.46808736
24cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.38431341
25detection of molecule of bacterial origin (GO:0032490)3.34905178
26regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.32961307
27complement activation, alternative pathway (GO:0006957)3.28076031
28cardiac muscle cell development (GO:0055013)3.24929399
29lymph vessel development (GO:0001945)3.24866703
30endocardial cushion development (GO:0003197)3.24513123
31regulation of apoptotic cell clearance (GO:2000425)3.22786311
32collagen fibril organization (GO:0030199)3.18304819
33plasma membrane repair (GO:0001778)3.18211252
34negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.13618446
35actin-mediated cell contraction (GO:0070252)3.11553943
36positive regulation of macrophage cytokine production (GO:0060907)3.11503262
37actomyosin structure organization (GO:0031032)3.10426550
38cardiac cell development (GO:0055006)3.09447903
39negative regulation of cell killing (GO:0031342)3.07619293
40negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.07619293
41sequestering of extracellular ligand from receptor (GO:0035581)3.07359921
42ovulation from ovarian follicle (GO:0001542)3.06059211
43carnitine shuttle (GO:0006853)3.03733336
44positive regulation of fibroblast migration (GO:0010763)3.03136404
45cardiac muscle cell proliferation (GO:0060038)3.02998319
46antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.02715196
47positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.00154705
48cellular extravasation (GO:0045123)2.97213279
49regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.94262148
50synaptic vesicle docking involved in exocytosis (GO:0016081)2.93303784
51pathway-restricted SMAD protein phosphorylation (GO:0060389)2.90852881
52fatty acid transmembrane transport (GO:1902001)2.90730882
53glomerular visceral epithelial cell development (GO:0072015)2.90717502
54positive regulation by symbiont of host defense response (GO:0052509)2.89821685
55modulation by symbiont of host defense response (GO:0052031)2.89821685
56modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.89821685
57modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.89821685
58positive regulation by organism of defense response of other organism involved in symbiotic interact2.89821685
59modulation by symbiont of host immune response (GO:0052553)2.89821685
60endothelial cell morphogenesis (GO:0001886)2.87708285
61heart trabecula formation (GO:0060347)2.86454620
62negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.86052250
63import into cell (GO:0098657)2.84431508
64regulation of complement activation (GO:0030449)2.81937781
65cell proliferation involved in metanephros development (GO:0072203)2.78289739
66positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.77715386
67peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.76853958
68angiogenesis involved in wound healing (GO:0060055)2.76440663
69blood vessel maturation (GO:0001955)2.75829210
70actin filament-based movement (GO:0030048)2.75346296
71L-amino acid import (GO:0043092)2.74138874
72endocardial cushion morphogenesis (GO:0003203)2.72243712
73cell-substrate junction assembly (GO:0007044)2.69679075
74regulation of ARF protein signal transduction (GO:0032012)2.68554526
75collagen metabolic process (GO:0032963)2.67295733
76regulation of p38MAPK cascade (GO:1900744)2.66651611
77substrate adhesion-dependent cell spreading (GO:0034446)2.65668147
78leukocyte migration involved in inflammatory response (GO:0002523)2.63545830
79regulation of T-helper 2 cell differentiation (GO:0045628)2.62476052
80multicellular organismal macromolecule metabolic process (GO:0044259)2.61542499
81cell adhesion mediated by integrin (GO:0033627)2.59898257
82positive regulation of receptor recycling (GO:0001921)2.59613822
83endothelial cell chemotaxis (GO:0035767)2.59319415
84glomerulus development (GO:0032835)2.59249275
85regulation of protein activation cascade (GO:2000257)2.58881852
86platelet aggregation (GO:0070527)2.58303907
87cell migration involved in sprouting angiogenesis (GO:0002042)2.58017635
88endodermal cell differentiation (GO:0035987)2.57908756
89metanephric mesenchyme development (GO:0072075)2.57839853
90negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.57776562
91cellular response to epinephrine stimulus (GO:0071872)2.57438701
92epithelial cell-cell adhesion (GO:0090136)2.57354395
93stress fiber assembly (GO:0043149)2.56995987
94chondrocyte proliferation (GO:0035988)2.56341733
95patterning of blood vessels (GO:0001569)2.55295499
96detection of external biotic stimulus (GO:0098581)2.55199404
97insulin-like growth factor receptor signaling pathway (GO:0048009)2.55061131
98macrophage activation involved in immune response (GO:0002281)2.54792635
99muscle tissue morphogenesis (GO:0060415)2.54544878
100response to parathyroid hormone (GO:0071107)2.54228516
101cardiac muscle contraction (GO:0060048)2.54138380
102antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.53589981
103positive regulation of p38MAPK cascade (GO:1900745)2.53126393
104negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.52585975
105smooth muscle tissue development (GO:0048745)2.52371496
106collagen catabolic process (GO:0030574)2.52335773
107phagocytosis, recognition (GO:0006910)2.51904368
108multicellular organismal metabolic process (GO:0044236)2.50259763
109locomotory exploration behavior (GO:0035641)2.50023962
110low-density lipoprotein particle clearance (GO:0034383)2.49844362
111skin morphogenesis (GO:0043589)2.49606682
112growth hormone receptor signaling pathway (GO:0060396)2.49440131
113germ cell migration (GO:0008354)2.48881000
114mannose metabolic process (GO:0006013)2.48474512
115regulation of macrophage cytokine production (GO:0010935)2.48266362
116mesodermal cell differentiation (GO:0048333)2.47716107
117barbed-end actin filament capping (GO:0051016)2.46377354
118endothelium development (GO:0003158)2.45397454
119negative regulation of potassium ion transmembrane transport (GO:1901380)2.45163453
120cellular response to osmotic stress (GO:0071470)2.44926094
121cortical actin cytoskeleton organization (GO:0030866)2.44331699
122valine metabolic process (GO:0006573)2.43952036
123fibril organization (GO:0097435)2.43705695
124venous blood vessel morphogenesis (GO:0048845)2.43659217
125bundle of His cell to Purkinje myocyte communication (GO:0086069)2.43491413
126response to fluid shear stress (GO:0034405)2.43062175
127extracellular fibril organization (GO:0043206)2.42860655
128cell-matrix adhesion (GO:0007160)2.42467128
129transcytosis (GO:0045056)2.42407010
130glomerular epithelial cell development (GO:0072310)2.40807940
131multicellular organismal catabolic process (GO:0044243)2.40137841
132protein localization to endosome (GO:0036010)2.39944678
133positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.39475019
134galactose catabolic process (GO:0019388)2.38196446
135positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.32781341
136detection of other organism (GO:0098543)2.31898654
137antigen processing and presentation of endogenous antigen (GO:0019883)2.31066262
138dermatan sulfate biosynthetic process (GO:0030208)2.31060753
139cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.30402983
140negative regulation of type 2 immune response (GO:0002829)2.30192386
141amino acid import (GO:0043090)2.30023433
142regulation of platelet aggregation (GO:0090330)2.29554173
143type B pancreatic cell proliferation (GO:0044342)2.27723518
144dermatan sulfate metabolic process (GO:0030205)2.27011872
145cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.26166754
146negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.25712686
147negative regulation of T-helper cell differentiation (GO:0045623)2.25712686
148positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.22000508
149sodium ion export (GO:0071436)2.21058824
150synaptic vesicle maturation (GO:0016188)2.19793390
151cellular potassium ion homeostasis (GO:0030007)2.19337785
152negative regulation of smooth muscle cell migration (GO:0014912)2.18993777
153cell-substrate adherens junction assembly (GO:0007045)2.18863005
154focal adhesion assembly (GO:0048041)2.18863005
155potassium ion import (GO:0010107)2.18704042
156glutamate secretion (GO:0014047)2.18678517
157detection of biotic stimulus (GO:0009595)2.17199856
158protein targeting to plasma membrane (GO:0072661)2.17016195
159microglial cell activation (GO:0001774)2.16725670
160cortical cytoskeleton organization (GO:0030865)2.16429470
161positive regulation of cellular amide metabolic process (GO:0034250)2.16347781
162antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.15542446
163regulation of synaptic vesicle exocytosis (GO:2000300)2.15456986
164regulation of synaptic vesicle transport (GO:1902803)2.13217533
165phagocytosis, engulfment (GO:0006911)2.12679995
166synaptic vesicle exocytosis (GO:0016079)2.12301183
167membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.11150597
168positive regulation of Rap GTPase activity (GO:0032854)2.09621237
169response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.08491863
170response to host (GO:0075136)2.08491863
171response to host defenses (GO:0052200)2.08491863
172urinary tract smooth muscle contraction (GO:0014848)2.07247970
173cellular response to catecholamine stimulus (GO:0071870)2.05388825
174cellular response to monoamine stimulus (GO:0071868)2.05388825
175regulation of ARF GTPase activity (GO:0032312)2.05327575
176regulation of mast cell degranulation (GO:0043304)2.04159190
177regulation of myeloid leukocyte mediated immunity (GO:0002886)2.04115897
178response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.02453149
179response to host immune response (GO:0052572)2.02453149
180regulation of extracellular matrix disassembly (GO:0010715)2.01317595
181negative regulation of leukocyte chemotaxis (GO:0002689)2.01150284
182cerebellar granule cell differentiation (GO:0021707)2.00736649
183adherens junction assembly (GO:0034333)2.00573885
184response to epinephrine (GO:0071871)2.00486063
185tooth mineralization (GO:0034505)2.00382209
186regulation of leukocyte degranulation (GO:0043300)1.99806244
187cell communication by electrical coupling (GO:0010644)1.99315065
188positive regulation of gamma-delta T cell activation (GO:0046645)1.99097955
189regulation of amyloid precursor protein catabolic process (GO:1902991)1.99084026
190neutrophil activation involved in immune response (GO:0002283)1.99021412

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.62979678
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.10054428
3CLOCK_20551151_ChIP-Seq_293T_Human3.79005182
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.59231163
5* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.79135715
6EP300_21415370_ChIP-Seq_HL-1_Mouse2.76602868
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.55285843
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.52876073
9TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.52083553
10PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.35580860
11ESR2_21235772_ChIP-Seq_MCF-7_Human2.29827241
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.22175498
13EZH2_22144423_ChIP-Seq_EOC_Human2.21599447
14ESR1_21235772_ChIP-Seq_MCF-7_Human2.20937670
15CDX2_19796622_ChIP-Seq_MESCs_Mouse2.17527889
16ESR1_20079471_ChIP-ChIP_T-47D_Human2.14441219
17EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.09458522
18GATA2_21666600_ChIP-Seq_HMVEC_Human2.03101278
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.02398937
20TBX20_22080862_ChIP-Seq_HEART_Mouse2.01273947
21TBX20_22328084_ChIP-Seq_HEART_Mouse2.01273947
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.01008504
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.00602712
24DROSHA_22980978_ChIP-Seq_HELA_Human1.98435106
25TP63_17297297_ChIP-ChIP_HaCaT_Human1.97052478
26ELK3_25401928_ChIP-Seq_HUVEC_Human1.86677496
27LXR_22158963_ChIP-Seq_LIVER_Mouse1.85122464
28CJUN_26792858_Chip-Seq_BT549_Human1.82894129
29NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.81978200
30CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.81652715
31RXR_22158963_ChIP-Seq_LIVER_Mouse1.77588946
32RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.76520600
33GATA1_22025678_ChIP-Seq_K562_Human1.74861222
34SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.74446674
35PPAR_26484153_Chip-Seq_NCI-H1993_Human1.73677439
36FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.70993329
37PPARA_22158963_ChIP-Seq_LIVER_Mouse1.67501553
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.66215886
39MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.62507956
40SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.61196720
41SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.57110898
42BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.56953971
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.56305894
44MTF2_20144788_ChIP-Seq_MESCs_Mouse1.55154853
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.55095869
46WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.54658693
47FOXO3_23340844_ChIP-Seq_DLD1_Human1.51408455
48SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.48834335
49IKZF1_21737484_ChIP-ChIP_HCT116_Human1.48531529
50EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47900430
51KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.45711905
52RNF2_18974828_ChIP-Seq_MESCs_Mouse1.42475575
53EZH2_18974828_ChIP-Seq_MESCs_Mouse1.42475575
54JARID2_20075857_ChIP-Seq_MESCs_Mouse1.42138006
55MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.41318979
56* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.39933613
57GATA1_19941826_ChIP-Seq_K562_Human1.37361544
58SOX2_20726797_ChIP-Seq_SW620_Human1.36726930
59RNF2_27304074_Chip-Seq_ESCs_Mouse1.35493190
60HIF1A_21447827_ChIP-Seq_MCF-7_Human1.35399247
61JARID2_20064375_ChIP-Seq_MESCs_Mouse1.32814596
62PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32550501
63STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.31853351
64SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.30449478
65SOX9_24532713_ChIP-Seq_HFSC_Mouse1.29446840
66IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.28819218
67TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28747817
68SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.28604464
69RACK7_27058665_Chip-Seq_MCF-7_Human1.28449421
70SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.28305120
71GBX2_23144817_ChIP-Seq_PC3_Human1.28152118
72SALL4_18804426_ChIP-ChIP_XEN_Mouse1.26672746
73WT1_19549856_ChIP-ChIP_CCG9911_Human1.26165293
74SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.24793339
75SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.24793339
76ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23932440
77SUZ12_27294783_Chip-Seq_ESCs_Mouse1.22692280
78BRD4_25478319_ChIP-Seq_HGPS_Human1.22298709
79RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.22055022
80SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20841168
81* SPI1_23127762_ChIP-Seq_K562_Human1.20567796
82RUNX_20019798_ChIP-Seq_JUKART_Human1.20545169
83EED_16625203_ChIP-ChIP_MESCs_Mouse1.20427466
84TP53_16413492_ChIP-PET_HCT116_Human1.19715587
85* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.19411676
86EZH2_27294783_Chip-Seq_ESCs_Mouse1.18980670
87CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.18270741
88KDM2B_26808549_Chip-Seq_DND41_Human1.17287495
89ISL1_27105846_Chip-Seq_CPCs_Mouse1.16595108
90NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.15724351
91LXR_22292898_ChIP-Seq_THP-1_Human1.15130211
92GATA2_19941826_ChIP-Seq_K562_Human1.13333041
93JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13025361
94P300_27058665_Chip-Seq_ZR-75-30cells_Human1.11744173
95IRF8_22096565_ChIP-ChIP_GC-B_Human1.11580758
96FOXA2_19822575_ChIP-Seq_HepG2_Human1.09157345
97SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06918264
98WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05062657
99KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04809653
100RUNX1_27514584_Chip-Seq_MCF-7_Human1.04766946
101* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04620390
102* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04620390
103IRF8_27001747_Chip-Seq_BMDM_Mouse1.03647564
104KDM2B_26808549_Chip-Seq_K562_Human1.02040622
105MYB_21317192_ChIP-Seq_ERMYB_Mouse1.01874642
106SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01135741
107EZH2_27304074_Chip-Seq_ESCs_Mouse1.00657769
108ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00173292
109DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.00147241
110ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99831124
111EGR1_19374776_ChIP-ChIP_THP-1_Human0.98849546
112* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.97699465
113FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.96774579
114NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96745829
115GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95224373
116TP53_22127205_ChIP-Seq_IMR90_Human0.94527370
117DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94330398
118AHR_22903824_ChIP-Seq_MCF-7_Human0.94030997
119UBF1/2_26484160_Chip-Seq_HMECs_Human0.93901946
120ARNT_22903824_ChIP-Seq_MCF-7_Human0.93726705
121* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93568836
122JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93392151
123SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.93191727
124SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.93102073
125ZFP281_27345836_Chip-Seq_ESCs_Mouse0.91764987
126MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.91669530
127UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.91636156
128STAT6_21828071_ChIP-Seq_BEAS2B_Human0.91598391
129* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.91497677
130NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91098641
131ZNF263_19887448_ChIP-Seq_K562_Human0.90771598
132SMC1_22415368_ChIP-Seq_MEFs_Mouse0.89967540
133GATA4_25053715_ChIP-Seq_YYC3_Human0.89854431
134* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88986995
135* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.88793153
136NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.88733626
137* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.88663978
138* GATA1_19941827_ChIP-Seq_MEL_Mouse0.88469688
139IRF8_21731497_ChIP-ChIP_J774_Mouse0.88125209
140ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88014239
141VDR_24787735_ChIP-Seq_THP-1_Human0.87496519
142SMAD_19615063_ChIP-ChIP_OVARY_Human0.87004283
143KDM2B_26808549_Chip-Seq_JURKAT_Human0.86602183
144LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.86335470
145* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86033997
146* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.85886345
147VDR_24763502_ChIP-Seq_THP-1_Human0.83921061
148* TP53_23651856_ChIP-Seq_MEFs_Mouse0.83849580
149ZFP281_18757296_ChIP-ChIP_E14_Mouse0.83129300
150CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.82091885

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.84607325
2MP0003724_increased_susceptibility_to3.44791411
3MP0004084_abnormal_cardiac_muscle3.22317851
4MP0004272_abnormal_basement_membrane3.17292789
5MP0003279_aneurysm3.05023375
6MP0000751_myopathy2.94184847
7MP0002837_dystrophic_cardiac_calcinosis2.88920191
8MP0005275_abnormal_skin_tensile2.81285683
9MP0004036_abnormal_muscle_relaxation2.81149533
10MP0006054_spinal_hemorrhage2.64534953
11MP0004859_abnormal_synaptic_plasticity2.50272115
12MP0010368_abnormal_lymphatic_system2.48217115
13MP0003705_abnormal_hypodermis_morpholog2.44172234
14MP0005503_abnormal_tendon_morphology2.39552724
15MP0001958_emphysema2.37183453
16MP0003566_abnormal_cell_adhesion2.34404950
17MP0005330_cardiomyopathy2.30022809
18MP0008775_abnormal_heart_ventricle2.09808543
19MP0003690_abnormal_glial_cell1.99519978
20* MP0005620_abnormal_muscle_contractility1.91406588
21MP0000767_abnormal_smooth_muscle1.90427523
22MP0000013_abnormal_adipose_tissue1.90139491
23MP0010386_abnormal_urinary_bladder1.86733539
24MP0003436_decreased_susceptibility_to1.85096109
25MP0004215_abnormal_myocardial_fiber1.83520951
26MP0004130_abnormal_muscle_cell1.82454824
27MP0001879_abnormal_lymphatic_vessel1.82127958
28MP0006138_congestive_heart_failure1.78909965
29MP0000749_muscle_degeneration1.77448733
30MP0003828_pulmonary_edema1.73749074
31MP0002972_abnormal_cardiac_muscle1.71952186
32MP0009384_cardiac_valve_regurgitation1.68568185
33MP0005623_abnormal_meninges_morphology1.65334996
34MP0004185_abnormal_adipocyte_glucose1.64302753
35MP0010630_abnormal_cardiac_muscle1.63744046
36MP0000750_abnormal_muscle_regeneration1.61231145
37MP0004087_abnormal_muscle_fiber1.60705962
38MP0009780_abnormal_chondrocyte_physiolo1.58827321
39MP0005385_cardiovascular_system_phenoty1.56890226
40MP0001544_abnormal_cardiovascular_syste1.56890226
41MP0003329_amyloid_beta_deposits1.55284876
42MP0003303_peritoneal_inflammation1.52398858
43MP0005670_abnormal_white_adipose1.52196932
44MP0000920_abnormal_myelination1.49483950
45MP0005666_abnormal_adipose_tissue1.48276167
46MP0002166_altered_tumor_susceptibility1.45423504
47MP0000516_abnormal_urinary_system1.42042765
48MP0005367_renal/urinary_system_phenotyp1.42042765
49MP0003879_abnormal_hair_cell1.41622454
50MP0003191_abnormal_cellular_cholesterol1.41530463
51MP0005375_adipose_tissue_phenotype1.38561721
52MP0004484_altered_response_of1.38543730
53MP0001756_abnormal_urination1.38454102
54MP0000003_abnormal_adipose_tissue1.37588203
55* MP0000230_abnormal_systemic_arterial1.36102194
56MP0003045_fibrosis1.33787679
57MP0005388_respiratory_system_phenotype1.32963173
58MP0002133_abnormal_respiratory_system1.32963173
59MP0005023_abnormal_wound_healing1.32152363
60MP0004147_increased_porphyrin_level1.31730583
61MP0002128_abnormal_blood_circulation1.27606181
62MP0000343_altered_response_to1.26584133
63MP0003635_abnormal_synaptic_transmissio1.25834190
64MP0003300_gastrointestinal_ulcer1.20931377
65MP0002419_abnormal_innate_immunity1.20499480
66MP0000462_abnormal_digestive_system1.19686693
67MP0002254_reproductive_system_inflammat1.19578280
68MP0003075_altered_response_to1.18732695
69MP0004858_abnormal_nervous_system1.18400721
70MP0005164_abnormal_response_to1.18111254
71MP0002295_abnormal_pulmonary_circulatio1.16455037
72MP0001348_abnormal_lacrimal_gland1.16246228
73MP0003091_abnormal_cell_migration1.14337938
74MP0000534_abnormal_ureter_morphology1.13443010
75MP0005165_increased_susceptibility_to1.13152819
76MP0000249_abnormal_blood_vessel1.12316532
77MP0002108_abnormal_muscle_morphology1.10020692
78MP0009278_abnormal_bone_marrow1.09725457
79MP0001614_abnormal_blood_vessel1.09235983
80MP0005595_abnormal_vascular_smooth1.08945950
81MP0001661_extended_life_span1.08431855
82MP0001542_abnormal_bone_strength1.05439175
83MP0002009_preneoplasia1.03110694
84MP0001835_abnormal_antigen_presentation1.02770126
85MP0003385_abnormal_body_wall1.02237719
86MP0008004_abnormal_stomach_pH1.00118895
87MP0003633_abnormal_nervous_system0.99822425
88MP0005166_decreased_susceptibility_to0.99731715
89MP0002106_abnormal_muscle_physiology0.99569064
90MP0001486_abnormal_startle_reflex0.99562092
91MP0000266_abnormal_heart_morphology0.98466272
92MP0001986_abnormal_taste_sensitivity0.97877348
93MP0003183_abnormal_peptide_metabolism0.97853974
94* MP0004085_abnormal_heartbeat0.96711152
95MP0004883_abnormal_blood_vessel0.96455698
96MP0004510_myositis0.95329562
97MP0008569_lethality_at_weaning0.94989740
98MP0002925_abnormal_cardiovascular_devel0.94597368
99MP0002060_abnormal_skin_morphology0.94453894
100MP0002269_muscular_atrophy0.93524222
101MP0003137_abnormal_impulse_conducting0.93151068
102MP0005423_abnormal_somatic_nervous0.93098437
103MP0005369_muscle_phenotype0.92893586
104MP0005464_abnormal_platelet_physiology0.92795775
105MP0000685_abnormal_immune_system0.92465200
106MP0000604_amyloidosis0.92413349
107MP0005508_abnormal_skeleton_morphology0.91959136
108MP0006082_CNS_inflammation0.90555761
109MP0010352_gastrointestinal_tract_polyps0.89978702
110MP0000747_muscle_weakness0.89540770
111MP0002064_seizures0.89470788
112MP0008260_abnormal_autophagy0.89397613
113MP0002127_abnormal_cardiovascular_syste0.88978346
114MP0005409_darkened_coat_color0.88740082
115MP0003172_abnormal_lysosome_physiology0.88296525
116MP0004145_abnormal_muscle_electrophysio0.87954601
117MP0003567_abnormal_fetal_cardiomyocyte0.87251441
118MP0005257_abnormal_intraocular_pressure0.86091957
119MP0002933_joint_inflammation0.85716644
120MP0002006_tumorigenesis0.85288155
121MP0003448_altered_tumor_morphology0.84743353
122MP0001851_eye_inflammation0.84579070
123MP0004270_analgesia0.84422986
124MP0008874_decreased_physiological_sensi0.84333588
125MP0000569_abnormal_digit_pigmentation0.83860875
126MP0003950_abnormal_plasma_membrane0.83654238
127MP0005025_abnormal_response_to0.83044374
128MP0000759_abnormal_skeletal_muscle0.82614484
129MP0000537_abnormal_urethra_morphology0.79428973
130MP0002063_abnormal_learning/memory/cond0.78363914
131MP0001501_abnormal_sleep_pattern0.78058060
132MP0003631_nervous_system_phenotype0.76640449
133MP0005167_abnormal_blood-brain_barrier0.75735906
134* MP0001664_abnormal_digestion0.74959993
135MP0003866_abnormal_defecation0.74739700
136MP0002896_abnormal_bone_mineralization0.74047742
137MP0000733_abnormal_muscle_development0.73770694
138MP0005387_immune_system_phenotype0.72688032
139MP0001790_abnormal_immune_system0.72688032
140MP0001533_abnormal_skeleton_physiology0.72522629
141MP0000538_abnormal_urinary_bladder0.72133493
142MP0003795_abnormal_bone_structure0.70754320
143MP0005000_abnormal_immune_tolerance0.67780333
144MP0000465_gastrointestinal_hemorrhage0.66380006
145MP0008961_abnormal_basal_metabolism0.66142342
146MP0009643_abnormal_urine_homeostasis0.65874887
147MP0005390_skeleton_phenotype0.64838472
148MP0002135_abnormal_kidney_morphology0.64059532
149MP0002998_abnormal_bone_remodeling0.62673719
150MP0002168_other_aberrant_phenotype0.62205872

Predicted human phenotypes

RankGene SetZ-score
1Aortic aneurysm (HP:0004942)7.67816433
2Aortic dissection (HP:0002647)6.55532872
3Cerebral aneurysm (HP:0004944)4.75654849
4Ankle contracture (HP:0006466)4.62029859
5Facial diplegia (HP:0001349)4.54771863
6Broad metatarsal (HP:0001783)4.28153470
7Protrusio acetabuli (HP:0003179)4.03618280
8Type 1 muscle fiber predominance (HP:0003803)3.94034451
9Increased density of long bones (HP:0006392)3.92268806
10Papilledema (HP:0001085)3.75728959
11Right ventricular cardiomyopathy (HP:0011663)3.72875840
12Sudden death (HP:0001699)3.70979013
13Aneurysm (HP:0002617)3.64296146
14Increased connective tissue (HP:0009025)3.52525351
15Premature rupture of membranes (HP:0001788)3.49324910
16Muscle fiber splitting (HP:0003555)3.42284603
17Ventricular tachycardia (HP:0004756)3.38191540
18Hyporeflexia of lower limbs (HP:0002600)3.26274238
19Short hallux (HP:0010109)3.21596993
20Lipoatrophy (HP:0100578)3.10470740
21Aortic regurgitation (HP:0001659)3.01429510
22Bicuspid aortic valve (HP:0001647)2.99329463
23Aplasia/Hypoplasia of the hallux (HP:0008362)2.98534884
24Increased variability in muscle fiber diameter (HP:0003557)2.94476483
25Obstructive sleep apnea (HP:0002870)2.91431394
26Gastrointestinal dysmotility (HP:0002579)2.70540398
27Shallow orbits (HP:0000586)2.67739586
28Eczematoid dermatitis (HP:0000976)2.67586642
29Atrial fibrillation (HP:0005110)2.67470368
30Wrist flexion contracture (HP:0001239)2.65810067
31Systemic lupus erythematosus (HP:0002725)2.65435460
32Dilatation of the ascending aorta (HP:0005111)2.63710720
33Ulnar bowing (HP:0003031)2.63215121
34Abnormality of skeletal muscle fiber size (HP:0012084)2.62008664
35Myositis (HP:0100614)2.58374615
36Spinal rigidity (HP:0003306)2.57771081
37Orchitis (HP:0100796)2.57364867
38Mitral valve prolapse (HP:0001634)2.57173670
39Spontaneous hematomas (HP:0007420)2.55068238
40Neonatal short-limb short stature (HP:0008921)2.52050910
41Pulmonary artery stenosis (HP:0004415)2.47669658
42Vascular tortuosity (HP:0004948)2.47512384
43Osteolytic defects of the phalanges of the hand (HP:0009771)2.47143751
44Osteolytic defects of the hand bones (HP:0009699)2.47143751
45Genu recurvatum (HP:0002816)2.45414846
46Primary atrial arrhythmia (HP:0001692)2.42556760
47Arterial tortuosity (HP:0005116)2.41117414
48Supraventricular arrhythmia (HP:0005115)2.39327530
49Complement deficiency (HP:0004431)2.38377870
50Abnormality of the calf musculature (HP:0001430)2.38215727
51Mesangial abnormality (HP:0001966)2.32974897
52Radial bowing (HP:0002986)2.31085512
53Supraventricular tachycardia (HP:0004755)2.30293747
54Scapular winging (HP:0003691)2.29859935
55Rectal prolapse (HP:0002035)2.27860254
56Calf muscle hypertrophy (HP:0008981)2.27584566
57Mildly elevated creatine phosphokinase (HP:0008180)2.26436386
58Mild short stature (HP:0003502)2.25875910
59Cervical subluxation (HP:0003308)2.25062328
60Asymmetric septal hypertrophy (HP:0001670)2.24994620
61Abnormality of the 4th metacarpal (HP:0010012)2.23781723
62Blue sclerae (HP:0000592)2.22699079
63Long toe (HP:0010511)2.20561963
64Bladder diverticulum (HP:0000015)2.20188319
65Increased mean platelet volume (HP:0011877)2.20000439
66Spondylolisthesis (HP:0003302)2.19736334
67Abnormality of binocular vision (HP:0011514)2.19027158
68Diplopia (HP:0000651)2.19027158
69Mitral regurgitation (HP:0001653)2.18569620
70Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.17200204
71Short 4th metacarpal (HP:0010044)2.17200204
72Neoplasm of the heart (HP:0100544)2.16627276
73Testicular atrophy (HP:0000029)2.13401940
74Supranuclear gaze palsy (HP:0000605)2.13122122
75Follicular hyperkeratosis (HP:0007502)2.12669145
76Peritonitis (HP:0002586)2.08734098
77Retrobulbar optic neuritis (HP:0100654)2.08705116
78Optic neuritis (HP:0100653)2.08705116
79Dilated cardiomyopathy (HP:0001644)2.08607092
80Bowel diverticulosis (HP:0005222)2.08474438
81Slender build (HP:0001533)2.07939601
82Soft skin (HP:0000977)2.07339359
83Wormian bones (HP:0002645)2.06955878
84Hemiplegia (HP:0002301)2.03933011
85Abnormality of complement system (HP:0005339)2.03348868
86Hypoventilation (HP:0002791)2.02366212
87Bone cyst (HP:0012062)2.01985561
88Joint laxity (HP:0001388)2.01779888
89Exercise-induced muscle cramps (HP:0003710)2.00917214
90Hyperextensible skin (HP:0000974)1.99007606
91Broad ribs (HP:0000885)1.98642094
92Atrophic scars (HP:0001075)1.97818976
93Chondrocalcinosis (HP:0000934)1.97576525
94Gingivitis (HP:0000230)1.97231444
95Abnormal platelet volume (HP:0011876)1.95666705
96Mesomelia (HP:0003027)1.95592453
97Postural instability (HP:0002172)1.95358649
98Neurofibrillary tangles (HP:0002185)1.94822294
99Bowed forearm bones (HP:0003956)1.93182325
100Bowing of the arm (HP:0006488)1.93182325
101Lymphangioma (HP:0100764)1.92849651
102Overgrowth (HP:0001548)1.92731625
103Action tremor (HP:0002345)1.92603204
104Stroke (HP:0001297)1.91368887
105Persistence of primary teeth (HP:0006335)1.89941134
106Cellulitis (HP:0100658)1.89401202
107Emphysema (HP:0002097)1.88597385
108Camptodactyly of toe (HP:0001836)1.87772343
109Muscle hypertrophy of the lower extremities (HP:0008968)1.87744848
110Hypoplasia of the iris (HP:0007676)1.87630045
111Fragile skin (HP:0001030)1.86896363
112Abnormality of dentin (HP:0010299)1.86357472
113Tarsal synostosis (HP:0008368)1.85285612
114Abnormality of Sharpey fibers (HP:0100685)1.83153068
115Abnormality of the calcaneus (HP:0008364)1.83020469
116Myotonia (HP:0002486)1.82892500
117Atrioventricular block (HP:0001678)1.82389077
118Gastrointestinal infarctions (HP:0005244)1.82345988
119Exercise-induced myalgia (HP:0003738)1.82251343
120Abnormality of the peritoneum (HP:0002585)1.82160392
121Amyloidosis (HP:0011034)1.81819445
122EMG: myopathic abnormalities (HP:0003458)1.81320588
123Elbow flexion contracture (HP:0002987)1.81275079
124Prolonged bleeding time (HP:0003010)1.81269359
125Nephritis (HP:0000123)1.80517831
126Recurrent abscess formation (HP:0002722)1.79958167
127Palpitations (HP:0001962)1.79620649
128Absent frontal sinuses (HP:0002688)1.78887853
129Biconcave vertebral bodies (HP:0004586)1.78365974
130Round ear (HP:0100830)1.77976801
131Aortic valve stenosis (HP:0001650)1.77876478
132Hematochezia (HP:0002573)1.77267519
133Gingival bleeding (HP:0000225)1.76955373
134Striae distensae (HP:0001065)1.76333316
135Abnormality of macrophages (HP:0004311)1.75495382
136Knee flexion contracture (HP:0006380)1.75263922
137Wide anterior fontanel (HP:0000260)1.74830294
138Difficulty running (HP:0009046)1.73915116
139Recurrent gram-negative bacterial infections (HP:0005420)1.73267585
140Segmental peripheral demyelination/remyelination (HP:0003481)1.70074882
141Ankle clonus (HP:0011448)1.69895882
142Recurrent bacterial skin infections (HP:0005406)1.67783786
143Polycythemia (HP:0001901)1.67566272
144Episodic fever (HP:0001954)1.64950927
145Mitral stenosis (HP:0001718)1.63983265
146Abnormality of the pulmonary veins (HP:0011718)1.63554197
147Keratoconjunctivitis sicca (HP:0001097)1.62823229
148Bruising susceptibility (HP:0000978)1.60799172
149Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.60184379
150Ectopia lentis (HP:0001083)1.60061198
151Onion bulb formation (HP:0003383)1.57307498
152Annular pancreas (HP:0001734)1.53867672
153Coronal craniosynostosis (HP:0004440)1.53458923
154Thoracolumbar scoliosis (HP:0002944)1.52127834
155Craniofacial hyperostosis (HP:0004493)1.50242066

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK7.52605224
2TTN5.79363077
3DMPK3.76820425
4TRIB32.84595820
5RIPK42.59466997
6PDGFRA2.57589867
7PAK22.28711581
8ERN12.13374745
9TGFBR22.13257018
10TIE12.10312737
11LMTK21.95849304
12PIK3CG1.91238585
13RIPK11.81886271
14LATS11.77540296
15EPHB21.75250367
16STK381.73051267
17FRK1.71466512
18PKN21.70478851
19MARK21.67536573
20TNK21.59312512
21CAMK1D1.53942748
22PIK3CA1.51710102
23PRPF4B1.51305874
24KSR21.50166029
25PRKD21.50053303
26PINK11.49585792
27MST1R1.47946707
28NTRK31.42249291
29OBSCN1.41068994
30KDR1.39822527
31PAK61.38687933
32NUAK11.38670432
33FES1.35752201
34CDC42BPA1.34276500
35EEF2K1.33907370
36BLK1.32950192
37ZAP701.22499572
38MAPKAPK31.21472732
39DDR21.20431299
40MAP3K61.18596591
41SIK11.18363478
42KIT1.17848663
43CAMK1G1.17778143
44CSK1.17725178
45MET1.17435050
46NTRK11.16226682
47PTK2B1.14873013
48GRK51.08937411
49ILK1.08665263
50GRK61.08449030
51ROCK11.06943245
52PTK61.06520147
53DAPK31.01524955
54DAPK20.98599900
55SGK20.97663245
56IRAK40.96930721
57MAP3K10.95885881
58SGK2230.94915401
59SGK4940.94915401
60SGK30.93601344
61TRPM70.92972733
62PDGFRB0.92426747
63MAP3K130.92348543
64MAP2K30.89678334
65EPHA30.87998607
66MAPK70.87620193
67STK38L0.82898722
68HCK0.82581436
69PDPK10.82080065
70EPHB10.81539753
71PTK20.81477435
72LRRK20.80915689
73ZAK0.80556051
74BCKDK0.79846595
75PAK30.79235611
76PRKD30.79031995
77MARK10.78244591
78NEK90.77079371
79UHMK10.76067946
80RPS6KA20.74733526
81MAP3K110.74361106
82CAMKK10.73992072
83ADRBK10.72960078
84TESK10.72613722
85MAP3K70.72337820
86MAP3K20.72031787
87STK30.71676816
88MAP3K100.71550920
89PDK10.68018115
90PRKAA20.67829327
91GRK70.65219093
92FER0.64043856
93LIMK10.63471763
94FYN0.61556745
95FGFR20.61367799
96NTRK20.61345524
97FLT30.60299910
98LATS20.59513129
99STK110.57562195
100PAK10.56975486
101MAP2K40.56835910
102PRKD10.56455933
103STK240.55618266
104PHKG10.54962629
105PHKG20.54962629
106PDK40.54835864
107PDK30.54835864
108WNK40.54206423
109FGR0.53720038
110MARK30.53595901
111BTK0.53489319
112PRKCH0.53450575
113TAOK30.52776391
114CDK50.52691212
115PDK20.51158736
116EPHA40.49798381
117RPS6KC10.48885076
118RPS6KL10.48885076
119STK100.48755209
120RET0.48347153
121TGFBR10.47660263
122MAP2K10.47534507
123SYK0.47428017
124FGFR40.46336518
125MAPKAPK20.46333983
126TAOK10.45531704
127CAMK40.45357069
128DYRK1B0.44992432
129CAMK2B0.44490460
130SGK10.43651735
131MTOR0.43486986
132JAK30.43183346
133BMX0.42927392
134SCYL20.42774160
135JAK10.42488313
136RPS6KA60.42416850
137CAMK10.42208957
138MAPK120.41625000
139INSRR0.41084520
140WNK10.40628956
141GSK3A0.39483922
142FGFR30.37929369
143AKT30.34943318
144ROCK20.34797622
145JAK20.33497021
146CAMK2G0.32845737
147PRKG20.31548016
148MAP3K30.30880564
149TYK20.30506851
150PRKACB0.29775239
151SRC0.26548082
152MAPK40.26324200

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.25167900
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.04387246
3Dilated cardiomyopathy_Homo sapiens_hsa054142.98348201
4Focal adhesion_Homo sapiens_hsa045102.84354845
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.45281705
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.21570500
7Amoebiasis_Homo sapiens_hsa051461.97121426
8* Vascular smooth muscle contraction_Homo sapiens_hsa042701.96740854
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.85133755
10Complement and coagulation cascades_Homo sapiens_hsa046101.80188349
11Fatty acid degradation_Homo sapiens_hsa000711.78742338
12Staphylococcus aureus infection_Homo sapiens_hsa051501.75175902
13Propanoate metabolism_Homo sapiens_hsa006401.68666109
14Platelet activation_Homo sapiens_hsa046111.68092536
15PPAR signaling pathway_Homo sapiens_hsa033201.67371080
16Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.62937211
17Protein digestion and absorption_Homo sapiens_hsa049741.62868270
18Leukocyte transendothelial migration_Homo sapiens_hsa046701.52186983
19Proteoglycans in cancer_Homo sapiens_hsa052051.51954430
20Small cell lung cancer_Homo sapiens_hsa052221.51599722
21Long-term potentiation_Homo sapiens_hsa047201.47378021
22AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.44663902
23Fatty acid metabolism_Homo sapiens_hsa012121.40882971
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38518217
25Adherens junction_Homo sapiens_hsa045201.36706641
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.32872507
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.30630993
28Regulation of actin cytoskeleton_Homo sapiens_hsa048101.30485450
29Gap junction_Homo sapiens_hsa045401.27143273
30Insulin resistance_Homo sapiens_hsa049311.25978162
31Circadian entrainment_Homo sapiens_hsa047131.25568344
32Renin-angiotensin system_Homo sapiens_hsa046141.24691470
33* cGMP-PKG signaling pathway_Homo sapiens_hsa040221.23498717
34GnRH signaling pathway_Homo sapiens_hsa049121.22374498
35Viral myocarditis_Homo sapiens_hsa054161.21541991
36Caffeine metabolism_Homo sapiens_hsa002321.16620049
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.14900161
38Toxoplasmosis_Homo sapiens_hsa051451.14661657
39Morphine addiction_Homo sapiens_hsa050321.12434196
40Cholinergic synapse_Homo sapiens_hsa047251.10332997
41Adipocytokine signaling pathway_Homo sapiens_hsa049201.06992205
42Insulin secretion_Homo sapiens_hsa049111.06512807
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05954359
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.04860813
45Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04749239
46TGF-beta signaling pathway_Homo sapiens_hsa043501.04459735
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.04128369
48Glutamatergic synapse_Homo sapiens_hsa047241.02190096
49Calcium signaling pathway_Homo sapiens_hsa040201.01280532
50GABAergic synapse_Homo sapiens_hsa047271.00379841
51Chemokine signaling pathway_Homo sapiens_hsa040621.00040468
52Cardiac muscle contraction_Homo sapiens_hsa042600.99433099
53Neurotrophin signaling pathway_Homo sapiens_hsa047220.98969073
54Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.98905431
55B cell receptor signaling pathway_Homo sapiens_hsa046620.97698807
56Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.97177401
57Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97008233
58Lysine degradation_Homo sapiens_hsa003100.96681408
59Tuberculosis_Homo sapiens_hsa051520.96187769
60Phagosome_Homo sapiens_hsa041450.94378293
61Endocytosis_Homo sapiens_hsa041440.94073298
62Tight junction_Homo sapiens_hsa045300.93843869
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.93716702
64Amphetamine addiction_Homo sapiens_hsa050310.91544864
65PI3K-Akt signaling pathway_Homo sapiens_hsa041510.91156090
66Salivary secretion_Homo sapiens_hsa049700.90442383
67Choline metabolism in cancer_Homo sapiens_hsa052310.89074504
68Nitrogen metabolism_Homo sapiens_hsa009100.87329755
69MAPK signaling pathway_Homo sapiens_hsa040100.87063029
70Synaptic vesicle cycle_Homo sapiens_hsa047210.86911910
71Cocaine addiction_Homo sapiens_hsa050300.86529384
72Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.86521581
73Carbon metabolism_Homo sapiens_hsa012000.85760722
74Ovarian steroidogenesis_Homo sapiens_hsa049130.85144352
75Acute myeloid leukemia_Homo sapiens_hsa052210.84887310
76Leishmaniasis_Homo sapiens_hsa051400.83777914
77Inositol phosphate metabolism_Homo sapiens_hsa005620.82571665
78Tryptophan metabolism_Homo sapiens_hsa003800.82326547
79Dopaminergic synapse_Homo sapiens_hsa047280.82210275
80Chronic myeloid leukemia_Homo sapiens_hsa052200.81346633
81Toll-like receptor signaling pathway_Homo sapiens_hsa046200.81206774
82AMPK signaling pathway_Homo sapiens_hsa041520.80871873
83Renin secretion_Homo sapiens_hsa049240.80697579
84Other glycan degradation_Homo sapiens_hsa005110.80381756
85Melanogenesis_Homo sapiens_hsa049160.80336659
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.80229578
87Malaria_Homo sapiens_hsa051440.80031046
88Bile secretion_Homo sapiens_hsa049760.78516279
89Long-term depression_Homo sapiens_hsa047300.78369292
90Ras signaling pathway_Homo sapiens_hsa040140.77955562
91Oxytocin signaling pathway_Homo sapiens_hsa049210.77799434
92Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.76701156
93Pyruvate metabolism_Homo sapiens_hsa006200.76348594
94Non-small cell lung cancer_Homo sapiens_hsa052230.75980709
95Renal cell carcinoma_Homo sapiens_hsa052110.75490419
96Pertussis_Homo sapiens_hsa051330.74934610
97ErbB signaling pathway_Homo sapiens_hsa040120.74498282
98African trypanosomiasis_Homo sapiens_hsa051430.74375497
99Endometrial cancer_Homo sapiens_hsa052130.74305614
100ABC transporters_Homo sapiens_hsa020100.72629916
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69559094
102Pancreatic secretion_Homo sapiens_hsa049720.69371147
103mTOR signaling pathway_Homo sapiens_hsa041500.69138297
104Prolactin signaling pathway_Homo sapiens_hsa049170.68864338
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.68053790
106MicroRNAs in cancer_Homo sapiens_hsa052060.67935312
107Rap1 signaling pathway_Homo sapiens_hsa040150.67662647
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66640292
109Jak-STAT signaling pathway_Homo sapiens_hsa046300.65095997
110TNF signaling pathway_Homo sapiens_hsa046680.64692101
111Osteoclast differentiation_Homo sapiens_hsa043800.64346219
112Pathways in cancer_Homo sapiens_hsa052000.64125715
113beta-Alanine metabolism_Homo sapiens_hsa004100.61577238
114Hippo signaling pathway_Homo sapiens_hsa043900.61384305
115Insulin signaling pathway_Homo sapiens_hsa049100.60847167
116Pancreatic cancer_Homo sapiens_hsa052120.59020519
117Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58620904
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58521675
119Type II diabetes mellitus_Homo sapiens_hsa049300.58494368
120Bladder cancer_Homo sapiens_hsa052190.58378863
121Gastric acid secretion_Homo sapiens_hsa049710.58241795
122Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57990674
123Notch signaling pathway_Homo sapiens_hsa043300.56578465
124cAMP signaling pathway_Homo sapiens_hsa040240.56141516
125Arginine biosynthesis_Homo sapiens_hsa002200.55934830
126Starch and sucrose metabolism_Homo sapiens_hsa005000.55781898
127Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54949151
128Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.54929290
129HIF-1 signaling pathway_Homo sapiens_hsa040660.54404357
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53148344
131Dorso-ventral axis formation_Homo sapiens_hsa043200.51618431
132Arachidonic acid metabolism_Homo sapiens_hsa005900.51546990
133Glucagon signaling pathway_Homo sapiens_hsa049220.50879142
134Thyroid hormone synthesis_Homo sapiens_hsa049180.48235744
135Prostate cancer_Homo sapiens_hsa052150.48004402
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47775575
137Fatty acid biosynthesis_Homo sapiens_hsa000610.47507540
138Glycerolipid metabolism_Homo sapiens_hsa005610.47206728
139Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46871245
140Salmonella infection_Homo sapiens_hsa051320.45862413
141Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.43886970
142Phospholipase D signaling pathway_Homo sapiens_hsa040720.42553471
143Phenylalanine metabolism_Homo sapiens_hsa003600.42190729
144Glioma_Homo sapiens_hsa052140.41560474
145Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.40023988
146Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.39823496
147Hematopoietic cell lineage_Homo sapiens_hsa046400.39667877
148VEGF signaling pathway_Homo sapiens_hsa043700.39554923
149Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38653260
150Prion diseases_Homo sapiens_hsa050200.37879206
151Melanoma_Homo sapiens_hsa052180.37587859
152Estrogen signaling pathway_Homo sapiens_hsa049150.35995673
153FoxO signaling pathway_Homo sapiens_hsa040680.35733419

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