MS4A10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Most MS4A genes, including MS4A10, encode proteins with at least 4 potential transmembrane domains and N- and C-terminal cytoplasmic domains encoded by distinct exons. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vitamin A metabolic process (GO:0006776)8.61583135
2regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)8.11793503
3adhesion of symbiont to host cell (GO:0044650)7.51798871
4virion attachment to host cell (GO:0019062)7.51798871
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.99145081
6flavonoid metabolic process (GO:0009812)6.65882972
7positive regulation of lipoprotein lipase activity (GO:0051006)6.48512365
8positive regulation of triglyceride lipase activity (GO:0061365)6.48512365
9phospholipid efflux (GO:0033700)6.47224951
10regulation of cholesterol esterification (GO:0010872)6.39106940
11regulation of guanylate cyclase activity (GO:0031282)6.37244738
12regulation of triglyceride catabolic process (GO:0010896)6.29582857
13adhesion of symbiont to host (GO:0044406)6.21397773
14plasma lipoprotein particle assembly (GO:0034377)5.88946786
15digestive system process (GO:0022600)5.70508556
16drug catabolic process (GO:0042737)5.66429671
17protein-lipid complex assembly (GO:0065005)5.59912801
18modified amino acid transport (GO:0072337)5.53519718
19actin filament depolymerization (GO:0030042)5.46786428
20positive regulation of guanylate cyclase activity (GO:0031284)5.32211287
21cholesterol efflux (GO:0033344)5.27250599
22epoxygenase P450 pathway (GO:0019373)5.20274922
23lipoprotein metabolic process (GO:0042157)5.06326805
24hormone catabolic process (GO:0042447)5.05078034
25purine nucleotide salvage (GO:0032261)4.98175034
26drinking behavior (GO:0042756)4.94959678
27very-low-density lipoprotein particle assembly (GO:0034379)4.88912758
28behavioral response to nicotine (GO:0035095)4.82641535
29purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.81616471
303-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.81616471
31positive regulation of fatty acid biosynthetic process (GO:0045723)4.75041310
32diacylglycerol metabolic process (GO:0046339)4.64331992
33fat-soluble vitamin biosynthetic process (GO:0042362)4.63414983
34peptide hormone processing (GO:0016486)4.58413956
35digestion (GO:0007586)4.55947448
36reverse cholesterol transport (GO:0043691)4.54302832
37peptide catabolic process (GO:0043171)4.44633984
38glucose 6-phosphate metabolic process (GO:0051156)4.43630326
39fucose catabolic process (GO:0019317)4.37733606
40L-fucose metabolic process (GO:0042354)4.37733606
41L-fucose catabolic process (GO:0042355)4.37733606
42sterol transport (GO:0015918)4.26980355
43cholesterol transport (GO:0030301)4.26980355
44cellular response to hepatocyte growth factor stimulus (GO:0035729)4.26419446
45response to hepatocyte growth factor (GO:0035728)4.26419446
46negative regulation of sterol transport (GO:0032372)4.25018949
47negative regulation of cholesterol transport (GO:0032375)4.25018949
48cholesterol homeostasis (GO:0042632)4.20264749
49sterol homeostasis (GO:0055092)4.15446495
50oligosaccharide catabolic process (GO:0009313)4.13740431
51bundle of His cell to Purkinje myocyte communication (GO:0086069)4.12804055
52vitamin biosynthetic process (GO:0009110)4.07998769
53lipoprotein transport (GO:0042953)4.02826087
54high-density lipoprotein particle remodeling (GO:0034375)3.98705446
55regulation of cGMP biosynthetic process (GO:0030826)3.94823777
56exogenous drug catabolic process (GO:0042738)3.92624483
57regulation of bile acid biosynthetic process (GO:0070857)3.91841097
58alkaloid metabolic process (GO:0009820)3.91536070
59positive regulation of triglyceride metabolic process (GO:0090208)3.87019175
60response to hydroperoxide (GO:0033194)3.81513036
61phenylpropanoid metabolic process (GO:0009698)3.80306654
62sulfation (GO:0051923)3.79226011
63regulation of lipoprotein metabolic process (GO:0050746)3.76255577
64positive regulation of T cell differentiation in thymus (GO:0033089)3.73492010
65regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.73316257
66protein-lipid complex remodeling (GO:0034368)3.71179468
67macromolecular complex remodeling (GO:0034367)3.71179468
68plasma lipoprotein particle remodeling (GO:0034369)3.71179468
69NADH metabolic process (GO:0006734)3.68351721
70regulation of cGMP metabolic process (GO:0030823)3.68072446
71proline transport (GO:0015824)3.67686531
72regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.63744169
73endocrine process (GO:0050886)3.63744169
74regulation of systemic arterial blood pressure by hormone (GO:0001990)3.63744169
75sulfate transmembrane transport (GO:1902358)3.63596112
76plasma lipoprotein particle organization (GO:0071827)3.62819192
77protein-lipid complex subunit organization (GO:0071825)3.60549626
78regulation of digestive system process (GO:0044058)3.58956914
79thyroid hormone metabolic process (GO:0042403)3.56590943
80quinone biosynthetic process (GO:1901663)3.56282773
81bile acid and bile salt transport (GO:0015721)3.54976179
82sphingomyelin metabolic process (GO:0006684)3.54834796
83transepithelial transport (GO:0070633)3.54582568
84phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.54564445
85positive regulation of fatty acid transport (GO:2000193)3.52802757
86water-soluble vitamin biosynthetic process (GO:0042364)3.52582555
87sulfur compound transport (GO:0072348)3.50236580
88regulation of penile erection (GO:0060405)3.49723021
89negative regulation of thymocyte apoptotic process (GO:0070244)3.48653127
90cobalamin metabolic process (GO:0009235)3.42672891
91mature B cell differentiation involved in immune response (GO:0002313)3.42216664
92positive regulation of lipid catabolic process (GO:0050996)3.40001652
93uronic acid metabolic process (GO:0006063)3.39232699
94glucuronate metabolic process (GO:0019585)3.39232699
95innate immune response in mucosa (GO:0002227)3.37870372
96negative regulation of digestive system process (GO:0060457)3.36559129
97response to phenylpropanoid (GO:0080184)3.36066887
98receptor guanylyl cyclase signaling pathway (GO:0007168)3.34538987
99histamine secretion (GO:0001821)3.28508939
100UDP-N-acetylglucosamine metabolic process (GO:0006047)3.27941941
101cellular glucuronidation (GO:0052695)3.27607924
102arginine metabolic process (GO:0006525)3.27136438
103positive regulation of icosanoid secretion (GO:0032305)3.24999717
104sperm capacitation (GO:0048240)3.24013720
105fat-soluble vitamin metabolic process (GO:0006775)3.23703696
106polyol transport (GO:0015791)3.23258730
107homocysteine metabolic process (GO:0050667)3.20692058
108intestinal epithelial cell development (GO:0060576)3.19991230
109regulation of systemic arterial blood pressure (GO:0003073)3.17957768
110positive regulation of cGMP biosynthetic process (GO:0030828)3.17168837
111glycerol metabolic process (GO:0006071)3.16413166
112bicarbonate transport (GO:0015701)3.15341511
113nucleotide salvage (GO:0043173)3.15212023
114regulation of cholesterol transport (GO:0032374)3.14700908
115regulation of sterol transport (GO:0032371)3.14700908
116cellular carbohydrate catabolic process (GO:0044275)3.12895856
117indolalkylamine metabolic process (GO:0006586)3.12837454
118transcytosis (GO:0045056)3.11989444
119sulfate transport (GO:0008272)3.09454758
120hydrogen peroxide catabolic process (GO:0042744)3.08487835
121drug metabolic process (GO:0017144)3.08212896
122cytidine deamination (GO:0009972)3.06895398
123cytidine metabolic process (GO:0046087)3.06895398
124cytidine catabolic process (GO:0006216)3.06895398
125kidney morphogenesis (GO:0060993)3.06002596
126pyrimidine ribonucleoside catabolic process (GO:0046133)3.04859941
127nucleobase catabolic process (GO:0046113)3.04608285
128fucosylation (GO:0036065)3.03467960
129adenosine metabolic process (GO:0046085)3.01369807
130cellular response to oxygen radical (GO:0071450)3.01158605
131cellular response to superoxide (GO:0071451)3.01158605
132vitamin transport (GO:0051180)3.00023087
133positive regulation of fatty acid beta-oxidation (GO:0032000)2.99241815
134heme transport (GO:0015886)2.98930955
135glycine transport (GO:0015816)2.90883208
136positive regulation of fatty acid oxidation (GO:0046321)2.90191502
137urate metabolic process (GO:0046415)2.89051131
138tryptophan catabolic process (GO:0006569)2.88818637
139indole-containing compound catabolic process (GO:0042436)2.88818637
140indolalkylamine catabolic process (GO:0046218)2.88818637
141auditory receptor cell differentiation (GO:0042491)2.87277881
142vitamin transmembrane transport (GO:0035461)2.86200970
143fructose metabolic process (GO:0006000)2.81642648
144cellular response to ATP (GO:0071318)2.79137102
145phenol-containing compound catabolic process (GO:0019336)2.78266461
146L-ascorbic acid metabolic process (GO:0019852)2.77760371
147oxidative demethylation (GO:0070989)2.76880300
148positive regulation of cGMP metabolic process (GO:0030825)2.76278275
149cGMP biosynthetic process (GO:0006182)2.76018715
150phosphatidylserine acyl-chain remodeling (GO:0036150)2.67502997
151phosphatidylinositol acyl-chain remodeling (GO:0036149)2.67021620
152alditol metabolic process (GO:0019400)2.65735624
153primary amino compound metabolic process (GO:1901160)2.62777276
154vitamin D metabolic process (GO:0042359)2.61141502
155serotonin metabolic process (GO:0042428)2.58688173
156detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.56582473
157glomerulus development (GO:0032835)2.53452587
158positive regulation of glycoprotein biosynthetic process (GO:0010560)2.53160874
159response to pheromone (GO:0019236)2.51560899
160vitamin catabolic process (GO:0009111)2.50780021
161fat-soluble vitamin catabolic process (GO:0042363)2.50780021
162indole-containing compound metabolic process (GO:0042430)2.50409092
163renal system process involved in regulation of blood volume (GO:0001977)2.49375807
164response to histamine (GO:0034776)2.48579744
165intestinal absorption (GO:0050892)13.6502451
166intestinal cholesterol absorption (GO:0030299)12.5722742
167angiotensin maturation (GO:0002003)12.2278575

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CDX2_20551321_ChIP-Seq_CACO-2_Human5.60937060
2SOX2_27498859_Chip-Seq_STOMACH_Mouse3.68717222
3HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.55764898
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.25940715
5GATA4_25053715_ChIP-Seq_YYC3_Human3.21251767
6ZNF274_21170338_ChIP-Seq_K562_Hela3.16855642
7VDR_22108803_ChIP-Seq_LS180_Human3.14370216
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.98875529
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.89965932
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.88796811
11GATA6_25053715_ChIP-Seq_YYC3_Human2.71114003
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.69600215
13SOX2_20726797_ChIP-Seq_SW620_Human2.60019834
14LXR_22158963_ChIP-Seq_LIVER_Mouse2.54643421
15EZH2_22144423_ChIP-Seq_EOC_Human2.42062188
16RXR_22158963_ChIP-Seq_LIVER_Mouse2.40975692
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.34718868
18SRY_22984422_ChIP-ChIP_TESTIS_Rat2.25603620
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.11613581
20NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.06312109
21RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.05686900
22PPAR_26484153_Chip-Seq_NCI-H1993_Human2.03430606
23GBX2_23144817_ChIP-Seq_PC3_Human2.02565825
24POU3F2_20337985_ChIP-ChIP_501MEL_Human2.00256520
25TP63_17297297_ChIP-ChIP_HaCaT_Human11.0831296
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.98082281
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97523700
28FUS_26573619_Chip-Seq_HEK293_Human1.96214719
29IGF1R_20145208_ChIP-Seq_DFB_Human1.94422518
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.94134603
31P300_19829295_ChIP-Seq_ESCs_Human1.87719404
32EGR1_23403033_ChIP-Seq_LIVER_Mouse1.85896634
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.80267035
34CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.75827183
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.72964798
36BCAT_22108803_ChIP-Seq_LS180_Human1.72849159
37KLF5_25053715_ChIP-Seq_YYC3_Human1.71874797
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.67543512
39SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.67310714
40ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.66591874
41ER_23166858_ChIP-Seq_MCF-7_Human1.63035623
42EWS_26573619_Chip-Seq_HEK293_Human1.62103865
43E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.61177465
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.60081641
45NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.59691221
46STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.58448749
47IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.57396114
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56593650
49NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.56045478
50CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.55813131
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.54369919
52NR3C1_21868756_ChIP-Seq_MCF10A_Human1.53053125
53KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.49475166
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.48026064
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.48026064
56RUNX1_27514584_Chip-Seq_MCF-7_Human1.47463381
57CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.47145273
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.46639863
59TCF4_18268006_ChIP-ChIP_LS174T_Human1.44511081
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.43636335
61HNF4A_19822575_ChIP-Seq_HepG2_Human1.43543185
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43046613
63HIF1A_21447827_ChIP-Seq_MCF-7_Human1.40999798
64NCOR_22424771_ChIP-Seq_293T_Human1.40426010
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39885904
66IRF1_19129219_ChIP-ChIP_H3396_Human1.39258116
67ATF3_27146783_Chip-Seq_COLON_Human1.38787060
68CDX2_22108803_ChIP-Seq_LS180_Human1.38599019
69KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.37855212
70TCF4_22108803_ChIP-Seq_LS180_Human1.37518252
71FOXA1_21572438_ChIP-Seq_LNCaP_Human1.37509776
72RACK7_27058665_Chip-Seq_MCF-7_Human1.34869988
73* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.34575363
74PRDM14_20953172_ChIP-Seq_ESCs_Human1.34256302
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.34091020
76GATA1_26923725_Chip-Seq_HPCs_Mouse1.33590061
77ETV2_25802403_ChIP-Seq_MESCs_Mouse1.33583842
78ESR2_21235772_ChIP-Seq_MCF-7_Human1.32829885
79* AUTS2_25519132_ChIP-Seq_293T-REX_Human1.31942709
80REST_21632747_ChIP-Seq_MESCs_Mouse1.31408128
81CBP_20019798_ChIP-Seq_JUKART_Human1.30888510
82IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30888510
83STAT3_23295773_ChIP-Seq_U87_Human1.29997364
84TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29933322
85SOX2_19829295_ChIP-Seq_ESCs_Human1.29839763
86NANOG_19829295_ChIP-Seq_ESCs_Human1.29839763
87PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29192038
88GATA1_22025678_ChIP-Seq_K562_Human1.28728985
89AR_25329375_ChIP-Seq_VCAP_Human1.28178519
90SMAD3_21741376_ChIP-Seq_EPCs_Human1.28044135
91SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27873448
92FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.26355232
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26226429
94TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25368746
95FOXO3_23340844_ChIP-Seq_DLD1_Human1.24438683
96TP53_22573176_ChIP-Seq_HFKS_Human1.23800994
97GATA2_19941826_ChIP-Seq_K562_Human1.22721916
98NFE2_27457419_Chip-Seq_LIVER_Mouse1.22678070
99SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22573010
100KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22053234
101MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.20627022
102TAF15_26573619_Chip-Seq_HEK293_Human1.20609312
103MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20430424
104SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19376737
105SMAD4_21799915_ChIP-Seq_A2780_Human1.19195805
106CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.18996598
107HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.18996275
108KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18627491
109TCF4_23295773_ChIP-Seq_U87_Human1.18499857
110AR_20517297_ChIP-Seq_VCAP_Human1.17623129
111ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.16438711
112ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16198417
113GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16191075
114RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.16043272
115SALL4_18804426_ChIP-ChIP_XEN_Mouse1.15326155
116FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14791571
117PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.13681815
118OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13532182
119RXR_22108803_ChIP-Seq_LS180_Human1.13355089
120SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11777298
121MYC_18940864_ChIP-ChIP_HL60_Human1.11629651
122* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.11339598
123POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.11126243
124GATA3_21878914_ChIP-Seq_MCF-7_Human1.10810866
125EZH2_27294783_Chip-Seq_NPCs_Mouse1.09850340
126BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09238131
127EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08307565
128TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08202177
129SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08104495
130CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06168663
131TAF2_19829295_ChIP-Seq_ESCs_Human1.06024332
132HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.05842331
133EED_16625203_ChIP-ChIP_MESCs_Mouse1.04987749
134CREB1_26743006_Chip-Seq_LNCaP_Human1.04948942
135MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.03715339
136P53_22387025_ChIP-Seq_ESCs_Mouse1.03680933
137POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03609319
138TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03609319
139SMAD4_21741376_ChIP-Seq_EPCs_Human1.03573911
140AR_21909140_ChIP-Seq_LNCAP_Human1.03138007
141ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02886185
142NANOG_20526341_ChIP-Seq_ESCs_Human1.01057297
143* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.00866401
144STAT6_21828071_ChIP-Seq_BEAS2B_Human1.00031083
145TAL1_26923725_Chip-Seq_HPCs_Mouse0.99873373
146FOXA2_19822575_ChIP-Seq_HepG2_Human0.98843309
147FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.98078154
148RUNX2_22187159_ChIP-Seq_PCA_Human0.97805253
149OCT4_18692474_ChIP-Seq_MEFs_Mouse0.96896541
150SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.96888381
151PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.96410129
152THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.96014690
153NANOG_18555785_ChIP-Seq_MESCs_Mouse0.93968348
154LXR_22292898_ChIP-Seq_THP-1_Human0.93586885
155JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93516177
156CTCF_27219007_Chip-Seq_Bcells_Human0.91871491
157SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90677488
158* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.89638848
159SMAD3_21741376_ChIP-Seq_HESCs_Human0.88464449
160CLOCK_20551151_ChIP-Seq_293T_Human0.87784502
161PHF8_20622854_ChIP-Seq_HELA_Human0.87705772
162CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87121537
163* BCL6_27268052_Chip-Seq_Bcells_Human0.85857578
164* BCOR_27268052_Chip-Seq_Bcells_Human0.83270801
165EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.82335074
166* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81536806
167EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.80845270
168MYC_19829295_ChIP-Seq_ESCs_Human0.80374112
169ESR1_21235772_ChIP-Seq_MCF-7_Human0.80254562
170AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.80249921
171CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.79536836
172SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.79480486
173STAT3_1855785_ChIP-Seq_MESCs_Mouse0.79250634
174EGR1_19032775_ChIP-ChIP_M12_Human0.79207660
175ZNF263_19887448_ChIP-Seq_K562_Human0.79119988
176P63_26484246_Chip-Seq_KERATINOCYTES_Human0.76257749
177* TP63_22573176_ChIP-Seq_HFKS_Human0.76044986
178* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.74848445
179FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.74374799
180ZNF217_24962896_ChIP-Seq_MCF-7_Human0.73815428
181GATA3_21867929_ChIP-Seq_CD8_Mouse0.73812783
182ESR1_20079471_ChIP-ChIP_T-47D_Human0.73480385
183JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.72709191
184P300_27058665_Chip-Seq_ZR-75-30cells_Human0.72553057
185STAT1_17558387_ChIP-Seq_HELA_Human0.72194216

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001666_abnormal_nutrient_absorption6.22020754
2MP0009840_abnormal_foam_cell5.56343134
3MP0003183_abnormal_peptide_metabolism4.27116400
4MP0002139_abnormal_hepatobiliary_system3.90417237
5MP0010234_abnormal_vibrissa_follicle3.51823680
6MP0003252_abnormal_bile_duct3.32513740
7MP0000462_abnormal_digestive_system3.24967768
8MP0004264_abnormal_extraembryonic_tissu3.06879095
9MP0008875_abnormal_xenobiotic_pharmacok2.98834856
10MP0005085_abnormal_gallbladder_physiolo2.81371139
11MP0010329_abnormal_lipoprotein_level2.78069842
12MP0003866_abnormal_defecation2.44665919
13MP0004019_abnormal_vitamin_homeostasis2.21165426
14MP0003195_calcinosis2.10370511
15MP0009697_abnormal_copulation2.05324385
16MP0002822_catalepsy2.02908481
17MP0005360_urolithiasis10.4031598
18MP0004147_increased_porphyrin_level1.95456028
19MP0005084_abnormal_gallbladder_morpholo1.91900321
20MP0001501_abnormal_sleep_pattern1.88594756
21MP0000537_abnormal_urethra_morphology1.87452394
22MP0009379_abnormal_foot_pigmentation1.74796876
23MP0005551_abnormal_eye_electrophysiolog1.73198710
24MP0005381_digestive/alimentary_phenotyp1.69543806
25MP0004043_abnormal_pH_regulation1.65627939
26MP0001663_abnormal_digestive_system1.64411850
27MP0002254_reproductive_system_inflammat1.63248530
28MP0005377_hearing/vestibular/ear_phenot1.61726549
29MP0003878_abnormal_ear_physiology1.61726549
30MP0004885_abnormal_endolymph1.60256799
31MP0001664_abnormal_digestion1.56150671
32MP0010155_abnormal_intestine_physiology1.53179377
33MP0000538_abnormal_urinary_bladder1.48878963
34MP0000427_abnormal_hair_cycle1.47221329
35MP0000490_abnormal_crypts_of1.46125996
36MP0005448_abnormal_energy_balance1.46049500
37MP0002102_abnormal_ear_morphology1.44724093
38MP0010352_gastrointestinal_tract_polyps1.44461870
39MP0002638_abnormal_pupillary_reflex1.43881110
40MP0000477_abnormal_intestine_morphology1.43473742
41MP0003718_maternal_effect1.38668585
42MP0001873_stomach_inflammation1.35739010
43MP0003300_gastrointestinal_ulcer1.30727042
44MP0002796_impaired_skin_barrier1.30404997
45MP0002272_abnormal_nervous_system1.29947442
46MP0005670_abnormal_white_adipose1.29395142
47MP0002089_abnormal_postnatal_growth/wei1.28162607
48MP0003705_abnormal_hypodermis_morpholog1.27044886
49MP0005365_abnormal_bile_salt1.25713394
50MP0003806_abnormal_nucleotide_metabolis1.23020500
51MP0002938_white_spotting1.22343190
52MP0000569_abnormal_digit_pigmentation1.19235978
53MP0003646_muscle_fatigue1.17827853
54MP0005645_abnormal_hypothalamus_physiol1.17716305
55MP0003191_abnormal_cellular_cholesterol1.17694262
56MP0002138_abnormal_hepatobiliary_system1.16254163
57MP0005332_abnormal_amino_acid1.14817933
58MP0003011_delayed_dark_adaptation1.11219418
59MP0005646_abnormal_pituitary_gland1.11185485
60MP0009745_abnormal_behavioral_response1.10054271
61MP0006072_abnormal_retinal_apoptosis1.08321070
62MP0001968_abnormal_touch/_nociception1.08050895
63MP0001986_abnormal_taste_sensitivity1.06451075
64MP0006054_spinal_hemorrhage1.02891241
65MP0004145_abnormal_muscle_electrophysio1.02059172
66MP0002733_abnormal_thermal_nociception0.99297617
67MP0002118_abnormal_lipid_homeostasis0.98199200
68MP0000631_abnormal_neuroendocrine_gland0.97529308
69MP0009643_abnormal_urine_homeostasis0.96302117
70MP0002064_seizures0.95280681
71MP0008872_abnormal_physiological_respon0.93280569
72MP0008877_abnormal_DNA_methylation0.92992319
73MP0004142_abnormal_muscle_tone0.91443257
74MP0000467_abnormal_esophagus_morphology0.91083472
75MP0001849_ear_inflammation0.90764914
76MP0000609_abnormal_liver_physiology0.90347422
77MP0005535_abnormal_body_temperature0.90054429
78MP0001756_abnormal_urination0.89800318
79MP0005266_abnormal_metabolism0.87457350
80MP0000015_abnormal_ear_pigmentation0.85856730
81MP0002734_abnormal_mechanical_nocicepti0.85564052
82MP0002277_abnormal_respiratory_mucosa0.85500275
83MP0006292_abnormal_olfactory_placode0.85336159
84MP0004133_heterotaxia0.85143987
85MP0002557_abnormal_social/conspecific_i0.84022054
86MP0002837_dystrophic_cardiac_calcinosis0.83354237
87MP0005501_abnormal_skin_physiology0.81935776
88MP0001440_abnormal_grooming_behavior0.80852733
89MP0001970_abnormal_pain_threshold0.80772078
90MP0005451_abnormal_body_composition0.80739984
91MP0004270_analgesia0.80655246
92MP0002736_abnormal_nociception_after0.80129075
93MP0003283_abnormal_digestive_organ0.77805731
94MP0001486_abnormal_startle_reflex0.77773902
95MP0005253_abnormal_eye_physiology0.77762312
96MP0002098_abnormal_vibrissa_morphology0.77246119
97MP0002876_abnormal_thyroid_physiology0.76377467
98MP0003868_abnormal_feces_composition0.74522161
99MP0004924_abnormal_behavior0.74351859
100MP0005386_behavior/neurological_phenoty0.74351859
101MP0002653_abnormal_ependyma_morphology0.74206794
102MP0001905_abnormal_dopamine_level0.74035381
103MP0010678_abnormal_skin_adnexa0.73848744
104MP0000026_abnormal_inner_ear0.71920604
105MP0002160_abnormal_reproductive_system0.71443241
106MP0003953_abnormal_hormone_level0.71402653
107MP0005389_reproductive_system_phenotype0.70634994
108MP0001764_abnormal_homeostasis0.70405288
109MP0004742_abnormal_vestibular_system0.70356178
110MP0002095_abnormal_skin_pigmentation0.70014551
111MP0004947_skin_inflammation0.69804616
112MP0002572_abnormal_emotion/affect_behav0.69686682
113MP0001529_abnormal_vocalization0.69685871
114MP0000372_irregular_coat_pigmentation0.69142254
115MP0003879_abnormal_hair_cell0.68473207
116MP0000566_synostosis0.68451339
117MP0005367_renal/urinary_system_phenotyp0.67452846
118MP0000516_abnormal_urinary_system0.67452846
119MP0000678_abnormal_parathyroid_gland0.66523565
120MP0009053_abnormal_anal_canal0.65197997
121MP0005174_abnormal_tail_pigmentation0.65075688
122MP0003453_abnormal_keratinocyte_physiol0.64299018
123MP0004215_abnormal_myocardial_fiber0.63999292
124MP0003315_abnormal_perineum_morphology0.63472507
125MP0003693_abnormal_embryo_hatching0.62846973
126MP0005319_abnormal_enzyme/_coenzyme0.61537879
127MP0005166_decreased_susceptibility_to0.61305970
128MP0009780_abnormal_chondrocyte_physiolo0.59535867
129MP0005167_abnormal_blood-brain_barrier0.59108257
130MP0003950_abnormal_plasma_membrane0.58347014
131MP0003638_abnormal_response/metabolism_0.55100353
132MP0002136_abnormal_kidney_physiology0.54405513
133MP0009765_abnormal_xenobiotic_induced0.54398408
134MP0005376_homeostasis/metabolism_phenot0.54359410
135MP0006138_congestive_heart_failure0.53087141
136MP0003119_abnormal_digestive_system0.50243850
137MP0001216_abnormal_epidermal_layer0.50117548
138MP0009642_abnormal_blood_homeostasis0.49980029
139MP0009115_abnormal_fat_cell0.48746695
140MP0001188_hyperpigmentation0.45375173
141MP0005636_abnormal_mineral_homeostasis0.45344401
142MP0001765_abnormal_ion_homeostasis0.45321204
143MP0009384_cardiac_valve_regurgitation0.44773830
144MP0000579_abnormal_nail_morphology0.40590617
145MP0000470_abnormal_stomach_morphology0.39765631
146MP0003656_abnormal_erythrocyte_physiolo0.39073128
147MP0000613_abnormal_salivary_gland0.38708669
148MP0005584_abnormal_enzyme/coenzyme_acti0.37635849
149MP0001191_abnormal_skin_condition0.36566996
150MP0000230_abnormal_systemic_arterial0.33867792
151MP0003941_abnormal_skin_development0.33842868
152MP0000377_abnormal_hair_follicle0.33144334
153MP0000604_amyloidosis0.32904959
154MP0001485_abnormal_pinna_reflex0.32885329
155MP0009764_decreased_sensitivity_to0.31858821
156MP0005023_abnormal_wound_healing0.31806825

Predicted human phenotypes

RankGene SetZ-score
1Ileus (HP:0002595)8.76758534
2Abnormality of glutamine family amino acid metabolism (HP:0010902)7.68281539
3Hypobetalipoproteinemia (HP:0003563)7.55544375
4Acanthocytosis (HP:0001927)7.53283443
5Autoimmune thrombocytopenia (HP:0001973)7.07351325
6Malnutrition (HP:0004395)5.91447737
7Abnormality of proline metabolism (HP:0010907)5.79331320
8Hydroxyprolinuria (HP:0003080)5.79331320
9Autoimmune hemolytic anemia (HP:0001890)5.38871027
10Cupped ribs (HP:0000887)5.03020025
11Conjugated hyperbilirubinemia (HP:0002908)4.93989688
12Pigmentary retinal degeneration (HP:0001146)4.64734420
13Mesangial abnormality (HP:0001966)4.62359217
14Right ventricular cardiomyopathy (HP:0011663)4.58110876
15Increased IgE level (HP:0003212)4.42941039
16Poikilocytosis (HP:0004447)4.37830735
17Hypolipoproteinemia (HP:0010981)4.33013761
18Widely patent fontanelles and sutures (HP:0004492)4.29765530
19B lymphocytopenia (HP:0010976)4.01323805
20Abnormality of B cell number (HP:0010975)4.01323805
21Fat malabsorption (HP:0002630)3.91069290
22Hyperglycinuria (HP:0003108)3.80767986
23Glycosuria (HP:0003076)3.69549734
24Abnormality of urine glucose concentration (HP:0011016)3.69549734
25Severe combined immunodeficiency (HP:0004430)3.61764104
26Facial shape deformation (HP:0011334)3.57569056
27Potter facies (HP:0002009)3.57569056
28Abdominal distention (HP:0003270)3.54191145
29Chronic diarrhea (HP:0002028)3.52619634
30Congenital stationary night blindness (HP:0007642)3.45028121
31Pancreatic cysts (HP:0001737)3.41960191
32True hermaphroditism (HP:0010459)3.34049013
33Combined immunodeficiency (HP:0005387)3.32078477
34Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.29700778
35Pendular nystagmus (HP:0012043)3.25709494
36Abnormal glucose tolerance (HP:0001952)3.25206525
37Pancreatic fibrosis (HP:0100732)3.23765043
38Decreased circulating renin level (HP:0003351)3.12921497
39Wide cranial sutures (HP:0010537)3.11942018
40Thyroiditis (HP:0100646)3.09159952
41Gastrointestinal dysmotility (HP:0002579)3.06647971
42Xanthomatosis (HP:0000991)3.05805166
43Molar tooth sign on MRI (HP:0002419)3.03305300
44Abnormality of midbrain morphology (HP:0002418)3.03305300
45Dehydration (HP:0001944)2.94340340
46Reticulocytosis (HP:0001923)2.93600989
47Chorioretinal atrophy (HP:0000533)2.92447942
48Abolished electroretinogram (ERG) (HP:0000550)2.89171475
49Abnormality of the vitamin B12 metabolism (HP:0004341)2.88241583
50Increased mean platelet volume (HP:0011877)2.83242557
51Nephrolithiasis (HP:0000787)2.77660582
52Nephronophthisis (HP:0000090)2.77565046
53Methylmalonic aciduria (HP:0012120)2.77429913
54Hypercholesterolemia (HP:0003124)2.73583387
55Abnormality of aspartate family amino acid metabolism (HP:0010899)2.70763938
56Hyperventilation (HP:0002883)2.69536253
57Congenital sensorineural hearing impairment (HP:0008527)2.68747035
58Abnormality of vitamin B metabolism (HP:0004340)2.66569897
59Abnormality of glycine metabolism (HP:0010895)2.59356634
60Abnormality of serine family amino acid metabolism (HP:0010894)2.59356634
61Abnormality of monocarboxylic acid metabolism (HP:0010996)2.59313148
62Proximal tubulopathy (HP:0000114)2.58691135
63Metabolic alkalosis (HP:0200114)2.57957042
64Abnormality of the renal cortex (HP:0011035)2.57758135
65Hyperphosphaturia (HP:0003109)2.47699754
66Abnormal platelet volume (HP:0011876)2.47343520
67Polycythemia (HP:0001901)2.43652134
68Attenuation of retinal blood vessels (HP:0007843)2.36585869
69Abnormality of purine metabolism (HP:0004352)2.35424228
70Abnormal rod and cone electroretinograms (HP:0008323)2.34185762
71Cheilitis (HP:0100825)2.33726165
72Abnormality of the renal medulla (HP:0100957)2.32691641
73Abnormality of vitamin metabolism (HP:0100508)2.32515676
74Alkalosis (HP:0001948)2.32383228
75Posterior subcapsular cataract (HP:0007787)2.32343071
76Abnormality of the gastric mucosa (HP:0004295)2.31862725
77Renal cortical cysts (HP:0000803)2.30324212
78Hypothermia (HP:0002045)2.30069355
79Abnormality of eosinophils (HP:0001879)2.29153203
80Decreased central vision (HP:0007663)2.28726945
81Abnormality of sulfur amino acid metabolism (HP:0004339)2.28164232
82Metabolic acidosis (HP:0001942)2.26052782
83Congenital, generalized hypertrichosis (HP:0004540)2.24816925
84Abnormal biliary tract morphology (HP:0012440)2.23091941
85Cystic liver disease (HP:0006706)2.22967545
86Nausea (HP:0002018)2.22491493
87Rectal prolapse (HP:0002035)2.20909311
88Villous atrophy (HP:0011473)2.18247516
89Abnormality of small intestinal villus morphology (HP:0011472)2.18247516
90Palpitations (HP:0001962)2.18127048
91Absent rod-and cone-mediated responses on ERG (HP:0007688)2.17790913
92Eosinophilia (HP:0001880)2.17788266
93Furrowed tongue (HP:0000221)2.17567861
94Pustule (HP:0200039)2.16646742
95Increased corneal curvature (HP:0100692)2.15587626
96Keratoconus (HP:0000563)2.15587626
97Methylmalonic acidemia (HP:0002912)2.15570252
98Megaloblastic anemia (HP:0001889)2.15407654
99Abnormality of renin-angiotensin system (HP:0000847)2.15239754
100Epidermoid cyst (HP:0200040)2.14462705
101Cholecystitis (HP:0001082)2.14031734
102Abnormal gallbladder physiology (HP:0012438)2.14031734
103Pili torti (HP:0003777)2.13441194
104Intrahepatic cholestasis (HP:0001406)2.13401138
105Decreased electroretinogram (ERG) amplitude (HP:0000654)2.11156484
106Woolly hair (HP:0002224)2.09894658
107Increased purine levels (HP:0004368)2.09374965
108Hyperuricemia (HP:0002149)2.09374965
109Hyperparathyroidism (HP:0000843)2.08635861
110Abnormality of nucleobase metabolism (HP:0010932)2.07318073
111Myopathic facies (HP:0002058)2.06829410
112Lethargy (HP:0001254)2.06655824
113Abnormal urine phosphate concentration (HP:0012599)2.06631361
114Genetic anticipation (HP:0003743)2.04317472
115Confusion (HP:0001289)2.02977160
116Tubular atrophy (HP:0000092)1.99026669
117Abnormality of reticulocytes (HP:0004312)1.98974201
118Progressive hearing impairment (HP:0001730)1.95907917
119Abnormality of magnesium homeostasis (HP:0004921)1.93574659
120Mildly elevated creatine phosphokinase (HP:0008180)1.93294295
121Sclerocornea (HP:0000647)1.93276727
122Ventricular fibrillation (HP:0001663)1.91624988
123Goiter (HP:0000853)1.91520720
124Milia (HP:0001056)1.90820666
125Syncope (HP:0001279)1.89876213
126Enlarged epiphyses (HP:0010580)1.89211569
127Abnormality of alanine metabolism (HP:0010916)1.88783505
128Hyperalaninemia (HP:0003348)1.88783505
129Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.88783505
130Medial flaring of the eyebrow (HP:0010747)1.88433518
131Granulocytopenia (HP:0001913)1.87615924
132Hyperglycinemia (HP:0002154)1.85547548
133Hypoproteinemia (HP:0003075)1.84853604
134Dicarboxylic aciduria (HP:0003215)1.84733448
135Abnormality of dicarboxylic acid metabolism (HP:0010995)1.84733448
136Abnormality of serum amino acid levels (HP:0003112)1.83828347
137Acute encephalopathy (HP:0006846)1.83202507
138Type II lissencephaly (HP:0007260)1.83164024
139Abnormal albumin level (HP:0012116)1.81759943
140Hypoalbuminemia (HP:0003073)1.81759943
141Hyperbilirubinemia (HP:0002904)1.80568508
142Flat acetabular roof (HP:0003180)1.79523521
143Hyperammonemia (HP:0001987)1.79416916
144Male pseudohermaphroditism (HP:0000037)1.76420204
145Inability to walk (HP:0002540)1.76389774
146Thin bony cortex (HP:0002753)1.76180965
147Progressive sensorineural hearing impairment (HP:0000408)1.75924984
148Abnormal urine output (HP:0012590)1.75630140
149Abnormality of the 1st metacarpal (HP:0010009)1.74146807
150Progressive inability to walk (HP:0002505)1.73841121
151Ketosis (HP:0001946)1.72200605
1523-Methylglutaconic aciduria (HP:0003535)1.72029986
153Bile duct proliferation (HP:0001408)1.71766283
154Abnormal biliary tract physiology (HP:0012439)1.71766283
155Limb dystonia (HP:0002451)1.71185845
156Chronic hepatic failure (HP:0100626)1.70889274
157Polygenic inheritance (HP:0010982)1.69730169
158Anencephaly (HP:0002323)1.68905217
159Progressive cerebellar ataxia (HP:0002073)1.68821512
160Symptomatic seizures (HP:0011145)1.67416511
161Biliary tract neoplasm (HP:0100574)1.66713429
162Mitochondrial inheritance (HP:0001427)1.65610852
163Abnormality of renal excretion (HP:0011036)1.65307927
164Enlarged kidneys (HP:0000105)1.65164783
165Pancreatitis (HP:0001733)1.65118194
166Late onset (HP:0003584)1.63534133

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B6.29318284
2FRK6.10059826
3MST45.36237273
4LMTK24.96280366
5MST1R4.29472055
6GRK63.64830764
7NME13.54095570
8PRKG23.45572778
9EPHA23.32341941
10ADRBK23.19513348
11AKT32.77045331
12BMPR1B2.73561538
13RIPK12.58850381
14MAP3K102.52009361
15MAP2K22.40332685
16CASK2.29887525
17OXSR12.21289041
18MAP4K22.20697591
19WNK32.19393091
20INSRR2.18924693
21NUAK12.11054164
22EPHB22.07845305
23MAP3K22.05871422
24WNK42.04310294
25PTK62.01052344
26PINK11.97858750
27TLK11.86653625
28ZAK1.80330695
29ERN11.75673488
30TESK21.62733340
31MAP2K61.60776646
32MET1.56606534
33DAPK21.49385740
34TESK11.42378466
35STK101.39237034
36MAPK131.38606026
37MAP3K111.34146806
38TTK1.31216767
39PBK1.29714305
40MAP3K41.26755480
41EPHA41.22873277
42TXK1.17523696
43PRKCI1.16379154
44TAOK11.14555025
45MAP3K81.14280659
46PIM21.13386188
47DDR21.08128781
48MAP3K91.02699401
49ADRBK10.99938014
50BMX0.97583298
51KSR20.97381305
52DYRK20.95386302
53MATK0.92919453
54TIE10.89909710
55TGFBR10.89640563
56EIF2AK10.87515097
57MUSK0.85613065
58MKNK20.85171228
59PNCK0.85106235
60MAP3K70.83445061
61PRKCE0.83254786
62PRKCG0.82007403
63PTK20.81916698
64BRSK20.81718897
65MAPKAPK30.80613495
66PIK3CA0.80383056
67ARAF0.79516218
68ERBB20.76770407
69EPHA30.75081564
70PAK40.74890205
71IRAK10.74417154
72FER0.73050015
73VRK20.72581429
74MAP2K70.72205501
75CSNK1G20.71982865
76NLK0.71538194
77RIPK40.70876885
78VRK10.70127679
79TAOK30.70004226
80TEC0.69884597
81FGFR20.69644615
82MAP3K30.69596824
83EPHB10.68843429
84MAPKAPK50.68509039
85PTK2B0.67915898
86IRAK30.66734828
87PRKAA20.65701557
88MAP2K10.65557028
89CSNK1G10.65322284
90CAMKK20.65076948
91MAP3K10.64844689
92CAMK2A0.62477836
93MAPK110.60876846
94BCKDK0.60378581
95CSNK1G30.58865439
96SCYL20.58768290
97PRKACA0.57321445
98PRKCZ0.55838601
99TBK10.55535653
100BRAF0.55364309
101TRIM280.55219097
102TAF10.54160536
103MYLK0.53950294
104STK38L0.53654383
105IKBKB0.52259780
106LATS10.52141301
107MAPK150.51912907
108MARK10.51017201
109DYRK1B0.50471271
110ITK0.46778695
111PDPK10.46108388
112GRK50.45559649
113AURKB0.43941512
114RPS6KA50.43744177
115PIM10.43560522
116PDK20.43145897
117KIT0.43080184
118WEE10.43008960
119CDK190.42665374
120ERBB40.42530502
121STK160.40909628
122ICK0.40348935
123LRRK20.37538321
124PHKG20.36236831
125PHKG10.36236831
126NTRK30.35871866
127PAK10.34277650
128BCR0.32998891
129PRKG10.32060109
130CDK120.31801062
131ERBB30.31756259
132CSNK1A1L0.31675241
133PRKAA10.31261389
134PLK20.30597589
135IGF1R0.29420441
136CSK0.29025369
137AKT20.28807355
138SYK0.28772635
139PRKCA0.28492088
140MAPKAPK20.27050968
141MAP3K120.25920897
142MAP4K10.24936106
143PDK10.23533417
144CDK60.22839231
145CSNK1A10.22715373
146LIMK10.22398329
147GRK10.22352083
148FGR0.22023667
149PRKCD0.21279137
150PAK30.21229203
151PRKACG0.20541446
152TYK20.20142173
153SRC0.19764403
154NEK10.18371193
155CAMK2G0.17148593
156PRKCQ0.17136352
157STK390.17014346
158NEK20.16599439
159STK110.16508464
160TYRO30.12990770
161CDK70.12753940
162STK30.11335670
163MELK0.11195081
164FYN0.11118346
165TNIK0.11021723
166DMPK0.10937048
167PDK40.10615004
168PDK30.10615004
169CAMK2D0.10534446
170CDK40.10513044
171GSK3A0.09610141

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049756.59969374
2Renin-angiotensin system_Homo sapiens_hsa046144.81186795
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.74217204
4Vitamin digestion and absorption_Homo sapiens_hsa049774.61216529
5Mineral absorption_Homo sapiens_hsa049784.15495507
6Galactose metabolism_Homo sapiens_hsa000522.85357437
7Caffeine metabolism_Homo sapiens_hsa002322.83292374
8Carbohydrate digestion and absorption_Homo sapiens_hsa049732.80111568
9Starch and sucrose metabolism_Homo sapiens_hsa005002.77225900
10Folate biosynthesis_Homo sapiens_hsa007902.50153821
11Protein digestion and absorption_Homo sapiens_hsa049742.41665050
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.05583007
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.99204892
14Fructose and mannose metabolism_Homo sapiens_hsa000511.91875369
15Bile secretion_Homo sapiens_hsa049761.90775310
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.74673413
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.72983252
18Histidine metabolism_Homo sapiens_hsa003401.71300738
19Glutathione metabolism_Homo sapiens_hsa004801.63438114
20Cyanoamino acid metabolism_Homo sapiens_hsa004601.56199722
21Sulfur metabolism_Homo sapiens_hsa009201.53799254
22Phototransduction_Homo sapiens_hsa047441.47604355
23Glycerolipid metabolism_Homo sapiens_hsa005611.40674686
24PPAR signaling pathway_Homo sapiens_hsa033201.31157832
25Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.27748691
26Sphingolipid metabolism_Homo sapiens_hsa006001.26901002
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.25135095
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.20176383
29Tryptophan metabolism_Homo sapiens_hsa003801.16315866
30Asthma_Homo sapiens_hsa053101.15679618
31Arginine biosynthesis_Homo sapiens_hsa002201.15325515
32Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.11421851
33Arginine and proline metabolism_Homo sapiens_hsa003301.09374998
34Oxidative phosphorylation_Homo sapiens_hsa001901.08784144
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.07786143
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.07461883
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.05630641
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.05579560
39Nicotine addiction_Homo sapiens_hsa050331.05372376
40Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.02125453
41Fatty acid degradation_Homo sapiens_hsa000711.01496561
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.99376850
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98785761
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.96690715
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85832199
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85644857
47Drug metabolism - other enzymes_Homo sapiens_hsa009830.82284908
48Nitrogen metabolism_Homo sapiens_hsa009100.82173877
49Propanoate metabolism_Homo sapiens_hsa006400.80492580
50Parkinsons disease_Homo sapiens_hsa050120.77394364
51ABC transporters_Homo sapiens_hsa020100.77189022
52Pyruvate metabolism_Homo sapiens_hsa006200.72284578
53Serotonergic synapse_Homo sapiens_hsa047260.71520084
54Pentose phosphate pathway_Homo sapiens_hsa000300.70700566
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68981257
56Thyroid hormone synthesis_Homo sapiens_hsa049180.68791481
57Glycerophospholipid metabolism_Homo sapiens_hsa005640.67340976
58Retinol metabolism_Homo sapiens_hsa008300.66693285
59Chemical carcinogenesis_Homo sapiens_hsa052040.66040339
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.66015940
61Carbon metabolism_Homo sapiens_hsa012000.63312558
62Arachidonic acid metabolism_Homo sapiens_hsa005900.60169435
63Cocaine addiction_Homo sapiens_hsa050300.59561714
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59487771
65Type I diabetes mellitus_Homo sapiens_hsa049400.57470547
66Allograft rejection_Homo sapiens_hsa053300.55994893
67Tight junction_Homo sapiens_hsa045300.55951281
68Taste transduction_Homo sapiens_hsa047420.55114020
69Graft-versus-host disease_Homo sapiens_hsa053320.54285029
70beta-Alanine metabolism_Homo sapiens_hsa004100.52745629
71Autoimmune thyroid disease_Homo sapiens_hsa053200.50581887
72Linoleic acid metabolism_Homo sapiens_hsa005910.50508993
73Biosynthesis of amino acids_Homo sapiens_hsa012300.45020728
74Huntingtons disease_Homo sapiens_hsa050160.44363044
75Cardiac muscle contraction_Homo sapiens_hsa042600.44126993
76Fatty acid biosynthesis_Homo sapiens_hsa000610.43805650
77Ovarian steroidogenesis_Homo sapiens_hsa049130.42557696
78Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.42250833
79Protein export_Homo sapiens_hsa030600.39514890
80Homologous recombination_Homo sapiens_hsa034400.37180898
81Amphetamine addiction_Homo sapiens_hsa050310.35416472
82Type II diabetes mellitus_Homo sapiens_hsa049300.34603884
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.32996830
84Tyrosine metabolism_Homo sapiens_hsa003500.32276425
85Glutamatergic synapse_Homo sapiens_hsa047240.32191074
86Bladder cancer_Homo sapiens_hsa052190.32078515
87Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.32041363
88Sulfur relay system_Homo sapiens_hsa041220.31768764
89Pancreatic secretion_Homo sapiens_hsa049720.31415745
90Morphine addiction_Homo sapiens_hsa050320.28966346
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28841804
92Primary immunodeficiency_Homo sapiens_hsa053400.28604727
93Metabolic pathways_Homo sapiens_hsa011000.27788914
94Olfactory transduction_Homo sapiens_hsa047400.27278740
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.27259780
96Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.26650511
97Fatty acid metabolism_Homo sapiens_hsa012120.26019463
98Dopaminergic synapse_Homo sapiens_hsa047280.25425966
99Hepatitis C_Homo sapiens_hsa051600.24938742
100Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.24220710
101Peroxisome_Homo sapiens_hsa041460.23521354
102Thyroid cancer_Homo sapiens_hsa052160.23468509
103African trypanosomiasis_Homo sapiens_hsa051430.23126313
104Ether lipid metabolism_Homo sapiens_hsa005650.23111353
105Intestinal immune network for IgA production_Homo sapiens_hsa046720.22299529
106Fatty acid elongation_Homo sapiens_hsa000620.21152629
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.20254625
108Gastric acid secretion_Homo sapiens_hsa049710.19526810
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.19110294
110Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.18306537
111Steroid biosynthesis_Homo sapiens_hsa001000.16787948
112Salmonella infection_Homo sapiens_hsa051320.15953506
113Lysine degradation_Homo sapiens_hsa003100.14695713
114GnRH signaling pathway_Homo sapiens_hsa049120.14237845
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.12430856
116Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.11739374
117Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.10836698
118Selenocompound metabolism_Homo sapiens_hsa004500.08760663
119Insulin secretion_Homo sapiens_hsa049110.07490687
120Adherens junction_Homo sapiens_hsa045200.06429263
121Butanoate metabolism_Homo sapiens_hsa006500.06220214
122Purine metabolism_Homo sapiens_hsa002300.03756931
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.01188871
124Alzheimers disease_Homo sapiens_hsa050100.01098422
125Renin secretion_Homo sapiens_hsa049240.00922483
126Phosphatidylinositol signaling system_Homo sapiens_hsa040700.00845798
127VEGF signaling pathway_Homo sapiens_hsa043700.00342995
128Long-term depression_Homo sapiens_hsa04730-0.0643498
129Gap junction_Homo sapiens_hsa04540-0.0540256
130Choline metabolism in cancer_Homo sapiens_hsa05231-0.0497952
131Phenylalanine metabolism_Homo sapiens_hsa00360-0.0442859
132NOD-like receptor signaling pathway_Homo sapiens_hsa04621-0.0377053
133Sphingolipid signaling pathway_Homo sapiens_hsa04071-0.0334073
134Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0303399
135Salivary secretion_Homo sapiens_hsa04970-0.0198617
136Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.0185069
137Hematopoietic cell lineage_Homo sapiens_hsa04640-0.0052864

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