MS4A12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cell surface protein found primarily in the apical membrane of colonocytes. Silencing of this gene in colon cancer cells inhibits the proliferation, cell motility, and chemotactic invasion of cells. This gene is part of a cluster of similar genes found on chromosome 11. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal absorption (GO:0050892)9.80469128
2sulfate transport (GO:0008272)8.41563525
3flavonoid metabolic process (GO:0009812)8.08225933
4positive regulation of respiratory burst (GO:0060267)7.93424635
5intestinal cholesterol absorption (GO:0030299)7.85234722
6angiotensin maturation (GO:0002003)6.75777665
7regulation of respiratory burst (GO:0060263)6.59565880
8positive regulation of synaptic transmission, GABAergic (GO:0032230)6.50127316
9oligosaccharide biosynthetic process (GO:0009312)6.43387299
10positive regulation of fatty acid beta-oxidation (GO:0032000)6.34172387
11renal system process involved in regulation of blood volume (GO:0001977)6.06425562
12UDP-N-acetylglucosamine metabolic process (GO:0006047)5.99163864
13cellular ketone body metabolic process (GO:0046950)5.97706596
14glucocorticoid biosynthetic process (GO:0006704)5.96832221
15regulation of guanylate cyclase activity (GO:0031282)5.95877762
16ethanol oxidation (GO:0006069)5.86567181
17glomerular filtration (GO:0003094)5.81629426
18positive regulation of keratinocyte differentiation (GO:0045618)5.60216622
19one-carbon metabolic process (GO:0006730)5.56184231
20sulfation (GO:0051923)5.49022738
21purine ribonucleoside bisphosphate metabolic process (GO:0034035)5.47420296
223-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)5.47420296
23bundle of His cell to Purkinje myocyte communication (GO:0086069)5.36901143
24actin filament depolymerization (GO:0030042)5.34213683
25vitamin A metabolic process (GO:0006776)5.31823125
26renal filtration (GO:0097205)5.30763328
27regulation of intracellular pH (GO:0051453)5.30731939
28positive regulation of epidermal cell differentiation (GO:0045606)5.14560773
29ketone body metabolic process (GO:1902224)5.13787628
30regulation of hydrogen peroxide metabolic process (GO:0010310)5.13420402
31positive regulation of fatty acid oxidation (GO:0046321)4.95170780
32regulation of bile acid biosynthetic process (GO:0070857)4.91211067
33regulation of cellular pH (GO:0030641)4.88845439
34maintenance of gastrointestinal epithelium (GO:0030277)4.84667967
35antibacterial humoral response (GO:0019731)4.84163463
36digestive system process (GO:0022600)4.83576684
37regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.76386134
38antimicrobial humoral response (GO:0019730)4.73754674
39negative regulation of myotube differentiation (GO:0010832)4.66716426
40ethanol metabolic process (GO:0006067)4.61311132
41intestinal epithelial cell development (GO:0060576)4.61210522
42desmosome organization (GO:0002934)4.59707720
43positive regulation of pseudopodium assembly (GO:0031274)4.50486721
44mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.49205311
45sulfur compound transport (GO:0072348)4.33317560
46renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)4.29916224
47labyrinthine layer development (GO:0060711)4.29296080
48drug catabolic process (GO:0042737)4.21350838
49regulation of pH (GO:0006885)4.14394961
50positive regulation of systemic arterial blood pressure (GO:0003084)4.14294430
51energy coupled proton transport, down electrochemical gradient (GO:0015985)4.11696215
52ATP synthesis coupled proton transport (GO:0015986)4.11696215
53cellular response to pH (GO:0071467)4.07598782
54response to hepatocyte growth factor (GO:0035728)4.06509594
55cellular response to hepatocyte growth factor stimulus (GO:0035729)4.06509594
56regulation of fatty acid beta-oxidation (GO:0031998)4.06180646
57regulation of pseudopodium assembly (GO:0031272)4.03609195
58adhesion of symbiont to host cell (GO:0044650)3.95435637
59virion attachment to host cell (GO:0019062)3.95435637
60regulation of triglyceride catabolic process (GO:0010896)3.95346357
61cGMP-mediated signaling (GO:0019934)3.93804601
62ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.90103732
63nucleoside bisphosphate biosynthetic process (GO:0033866)3.90103732
64purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.90103732
65transcytosis (GO:0045056)3.89926844
66sperm capacitation (GO:0048240)3.88389408
67glucose 6-phosphate metabolic process (GO:0051156)3.83203346
68pyrimidine-containing compound transmembrane transport (GO:0072531)3.82770848
69O-glycan processing (GO:0016266)3.80358328
70nucleoside diphosphate biosynthetic process (GO:0009133)3.77884756
71cellular monovalent inorganic cation homeostasis (GO:0030004)3.75601161
72positive regulation of guanylate cyclase activity (GO:0031284)3.74927390
73triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.70862703
74epithelial structure maintenance (GO:0010669)3.69465474
75transepithelial transport (GO:0070633)3.63554417
76thrombin receptor signaling pathway (GO:0070493)3.63247106
77bicarbonate transport (GO:0015701)3.62826820
78negative regulation of leukocyte chemotaxis (GO:0002689)3.62454173
79response to acidic pH (GO:0010447)3.59953042
80monovalent inorganic cation homeostasis (GO:0055067)3.58718168
81plasma lipoprotein particle assembly (GO:0034377)3.58029111
82hepatocyte apoptotic process (GO:0097284)3.57613604
83negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.57480196
84fructose metabolic process (GO:0006000)3.56984006
85regulation of cGMP biosynthetic process (GO:0030826)3.56024470
86bile acid and bile salt transport (GO:0015721)3.55513398
87excretion (GO:0007588)3.53138667
88cellular glucuronidation (GO:0052695)3.52623264
89regulation of systemic arterial blood pressure (GO:0003073)3.50450305
90innate immune response in mucosa (GO:0002227)3.50371908
91calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.47862173
92phospholipid efflux (GO:0033700)3.46675416
93hormone catabolic process (GO:0042447)3.46463986
94digestion (GO:0007586)3.46287199
95intermediate filament organization (GO:0045109)3.45106703
96viral transcription (GO:0019083)3.43299658
97regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.42789848
98cellular response to cAMP (GO:0071320)3.42414719
99sodium ion homeostasis (GO:0055078)3.42286904
100protein-lipid complex assembly (GO:0065005)3.41314781
101response to food (GO:0032094)3.40042335
102thyroid hormone metabolic process (GO:0042403)3.39235387
103cholesterol homeostasis (GO:0042632)3.36834687
104positive regulation of lipoprotein lipase activity (GO:0051006)3.36196175
105positive regulation of triglyceride lipase activity (GO:0061365)3.36196175
106nucleotide-sugar biosynthetic process (GO:0009226)3.34988735
107positive regulation of epidermis development (GO:0045684)3.33601867
108glucocorticoid metabolic process (GO:0008211)3.33462974
109sterol homeostasis (GO:0055092)3.33283862
110inner mitochondrial membrane organization (GO:0007007)3.31525447
111regulation of viral release from host cell (GO:1902186)3.31163375
112regulation of cholesterol esterification (GO:0010872)3.30308952
113drug transmembrane transport (GO:0006855)3.29487510
114defense response to fungus (GO:0050832)3.28018645
115membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.26915395
116very-low-density lipoprotein particle assembly (GO:0034379)3.25295484
117fucosylation (GO:0036065)3.25031878
118positive regulation of cellular response to oxidative stress (GO:1900409)3.24519139
119positive regulation of response to oxidative stress (GO:1902884)3.24519139
120regulation of actin nucleation (GO:0051125)3.24488020
121positive regulation of T cell differentiation in thymus (GO:0033089)3.24239734
122translational termination (GO:0006415)3.23667659
123glucuronate metabolic process (GO:0019585)3.22977744
124uronic acid metabolic process (GO:0006063)3.22977744
125receptor guanylyl cyclase signaling pathway (GO:0007168)3.22256849
126positive regulation of Cdc42 GTPase activity (GO:0043089)3.19970973
127regulation of chemokine secretion (GO:0090196)3.19095964
128killing of cells of other organism (GO:0031640)3.19074966
129disruption of cells of other organism (GO:0044364)3.19074966
130regulation of vitamin metabolic process (GO:0030656)3.17194632
131lipoprotein metabolic process (GO:0042157)3.15905363
132GDP-mannose metabolic process (GO:0019673)3.15809690
133sulfate transmembrane transport (GO:1902358)3.14397944
134activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.14395013
135ventricular cardiac muscle cell action potential (GO:0086005)3.14258629
136fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.13285119
137phenylpropanoid metabolic process (GO:0009698)3.12077975
138regulation of systemic arterial blood pressure by hormone (GO:0001990)3.10644730
139regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.10644730
140endocrine process (GO:0050886)3.10644730
141sulfur amino acid catabolic process (GO:0000098)3.08698947
142gap junction assembly (GO:0016264)3.07773382
143receptor recycling (GO:0001881)3.07209966
144regulation of keratinocyte differentiation (GO:0045616)3.05889052
145NADH metabolic process (GO:0006734)3.05135559
146ATP biosynthetic process (GO:0006754)3.05066774
147auditory receptor cell differentiation (GO:0042491)3.04437936
148positive regulation of lipid catabolic process (GO:0050996)3.03721399
149nucleotide-sugar metabolic process (GO:0009225)3.02987379
150negative regulation of protein tyrosine kinase activity (GO:0061099)3.00798122
151primary alcohol catabolic process (GO:0034310)3.00538112
152hemidesmosome assembly (GO:0031581)3.00375480
153response to nitrosative stress (GO:0051409)2.98801632
154lipoprotein transport (GO:0042953)2.97894122
155regulation of cholesterol homeostasis (GO:2000188)2.97680829
156respiratory electron transport chain (GO:0022904)2.95862676
157adhesion of symbiont to host (GO:0044406)2.95737769
158membrane hyperpolarization (GO:0060081)2.93367221
159negative regulation of keratinocyte proliferation (GO:0010839)2.90815543
160regulation of cGMP metabolic process (GO:0030823)2.88314359
161inorganic anion transmembrane transport (GO:0098661)2.87249759
162electron transport chain (GO:0022900)2.87030201
163trophectodermal cell differentiation (GO:0001829)2.86880779
164membrane repolarization during action potential (GO:0086011)2.86259022

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.45009560
2CDX2_20551321_ChIP-Seq_CACO-2_Human6.56700011
3SOX2_27498859_Chip-Seq_STOMACH_Mouse4.42577414
4HNF4A_19761587_ChIP-ChIP_CACO-2_Human4.02324147
5GATA4_25053715_ChIP-Seq_YYC3_Human3.54936361
6GATA6_25053715_ChIP-Seq_YYC3_Human3.48454330
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.44804833
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.36697796
9SOX2_20726797_ChIP-Seq_SW620_Human3.04756898
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.96219565
11SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.90625709
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.87807639
13CDX2_19796622_ChIP-Seq_MESCs_Mouse2.51243724
14RXR_22158963_ChIP-Seq_LIVER_Mouse2.48472101
15LXR_22158963_ChIP-Seq_LIVER_Mouse2.30652566
16SRY_22984422_ChIP-ChIP_TESTIS_Rat2.29316246
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.18178848
18FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.14148266
19NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.12606662
20IRF8_22096565_ChIP-ChIP_GC-B_Human2.10674443
21FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.04160373
22RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.98899620
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.98767913
24TCF4_18268006_ChIP-ChIP_LS174T_Human1.95677653
25KLF5_25053715_ChIP-Seq_YYC3_Human1.85126939
26PPAR_26484153_Chip-Seq_NCI-H1993_Human1.83864721
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.83774659
28ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.77748447
29FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.75201941
30ZNF263_19887448_ChIP-Seq_K562_Human1.74992981
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.73748771
32KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.72218990
33RUNX1_27514584_Chip-Seq_MCF-7_Human1.70310136
34AR_21909140_ChIP-Seq_LNCAP_Human1.68501200
35KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.67692789
36FOXO3_23340844_ChIP-Seq_DLD1_Human1.66848036
37DROSHA_22980978_ChIP-Seq_HELA_Human1.66822391
38TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.64429630
39TRIM28_21343339_ChIP-Seq_HEK293_Human1.63096020
40CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.58708952
41ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.58443757
42TCF3_18692474_ChIP-Seq_MEFs_Mouse1.52478325
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.49777565
44PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.46372471
45ATF3_27146783_Chip-Seq_COLON_Human1.45267486
46SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.44700826
47POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.43087280
48* CDX2_22108803_ChIP-Seq_LS180_Human1.40425280
49CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40395161
50CEBPB_22108803_ChIP-Seq_LS180_Human1.39512704
51ELF5_23300383_ChIP-Seq_T47D_Human1.39468732
52CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.38477382
53FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.38302550
54VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.36186832
55HNF4A_19822575_ChIP-Seq_HepG2_Human1.35541607
56KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.34988733
57RACK7_27058665_Chip-Seq_MCF-7_Human1.34045042
58ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.33262660
59RARG_19884340_ChIP-ChIP_MEFs_Mouse1.33117450
60OCT4_18692474_ChIP-Seq_MEFs_Mouse1.31068130
61GATA1_26923725_Chip-Seq_HPCs_Mouse1.26826924
62ESR2_21235772_ChIP-Seq_MCF-7_Human1.22345169
63JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.21441039
64ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.21016966
65AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.18168861
66LXR_22292898_ChIP-Seq_THP-1_Human1.15342270
67SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.15194357
68SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.15194357
69ESR1_21235772_ChIP-Seq_MCF-7_Human1.13833029
70CTNNB1_20460455_ChIP-Seq_HCT116_Human1.12304682
71NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.12028875
72GATA2_19941826_ChIP-Seq_K562_Human1.11709772
73CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.11497163
74EGR1_23403033_ChIP-Seq_LIVER_Mouse1.10051580
75IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.09677169
76FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09410872
77ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.08527653
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08396872
79STAT1_20625510_ChIP-Seq_HELA_Human1.07032193
80BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.06632479
81TET1_21451524_ChIP-Seq_MESCs_Mouse1.06247690
82P63_26484246_Chip-Seq_KERATINOCYTES_Human1.05407796
83BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.02249921
84EGR1_19032775_ChIP-ChIP_M12_Human1.00234464
85GATA3_24758297_ChIP-Seq_MCF-7_Human0.99872050
86FOXA2_19822575_ChIP-Seq_HepG2_Human0.98873523
87GATA1_19941826_ChIP-Seq_K562_Human0.98221893
88CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98053373
89CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96771082
90SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96641132
91MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.96008451
92SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.94926490
93CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94809685
94NANOG_20526341_ChIP-Seq_ESCs_Human0.94799302
95E2F1_20622854_ChIP-Seq_HELA_Human0.94388871
96SA1_27219007_Chip-Seq_Bcells_Human0.91540889
97KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.90579135
98KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.90579135
99KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.90579135
100SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89682926
101NANOG_18692474_ChIP-Seq_MEFs_Mouse0.88747858
102PHF8_20622854_ChIP-Seq_HELA_Human0.88236667
103GATA1_22383799_ChIP-Seq_G1ME_Mouse0.87712304
104NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.87313890
105HIF1A_21447827_ChIP-Seq_MCF-7_Human0.86988623
106RAD21_21589869_ChIP-Seq_MESCs_Mouse0.86735316
107ESR1_20079471_ChIP-ChIP_T-47D_Human0.86237129
108UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.85802949
109SOX2_18692474_ChIP-Seq_MEFs_Mouse0.85446612
110SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.85038844
111NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.84681946
112TP63_22573176_ChIP-Seq_HFKS_Human0.84039844
113CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.83886558
114PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.83492613
115CREB1_26743006_Chip-Seq_LNCaP_Human0.83025657
116CLOCK_20551151_ChIP-Seq_293T_Human0.83016697
117PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.82157878
118GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.81978134
119BCL6_27268052_Chip-Seq_Bcells_Human0.81545070
120FOXA1_25552417_ChIP-Seq_VCAP_Human0.81512997
121GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81313986
122STAT3_1855785_ChIP-Seq_MESCs_Mouse0.79948046
123SALL4_18804426_ChIP-ChIP_XEN_Mouse0.79751825
124ETS1_21867929_ChIP-Seq_TH2_Mouse0.79485872
125ZNF217_24962896_ChIP-Seq_MCF-7_Human0.78062815
126* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.77531686
127SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.77316639
128EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.76842894
129ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.74320951
130BCAT_22108803_ChIP-Seq_LS180_Human0.72719991
131SMAD3_21741376_ChIP-Seq_HESCs_Human0.72029052
132PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.71001494
133NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.70851074
134EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.70107049
135TDRD3_21172665_ChIP-Seq_MCF-7_Human0.69985885
136TCF3_18692474_ChIP-Seq_MESCs_Mouse0.69730515
137SOX9_24532713_ChIP-Seq_HFSC_Mouse0.68994284

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.75198061
2MP0001666_abnormal_nutrient_absorption5.15782729
3MP0010234_abnormal_vibrissa_follicle4.80204801
4MP0004264_abnormal_extraembryonic_tissu4.05214870
5MP0000462_abnormal_digestive_system4.05148513
6MP0002139_abnormal_hepatobiliary_system3.67393502
7MP0003866_abnormal_defecation3.58769080
8MP0009379_abnormal_foot_pigmentation3.31913026
9MP0005085_abnormal_gallbladder_physiolo3.04685892
10MP0003300_gastrointestinal_ulcer2.84788139
11MP0001663_abnormal_digestive_system2.71862501
12MP0002138_abnormal_hepatobiliary_system2.63328057
13MP0008875_abnormal_xenobiotic_pharmacok2.62139629
14MP0010155_abnormal_intestine_physiology2.60580928
15MP0005381_digestive/alimentary_phenotyp2.58390970
16MP0009840_abnormal_foam_cell2.57297601
17MP0003183_abnormal_peptide_metabolism2.38980761
18MP0000490_abnormal_crypts_of2.35161360
19MP0003283_abnormal_digestive_organ2.32086181
20MP0001664_abnormal_digestion2.17328031
21MP0003252_abnormal_bile_duct2.17239447
22MP0000477_abnormal_intestine_morphology2.14478740
23MP0010329_abnormal_lipoprotein_level2.08292729
24MP0010352_gastrointestinal_tract_polyps2.01587307
25MP0001873_stomach_inflammation2.00109995
26MP0000537_abnormal_urethra_morphology1.96062403
27MP0005670_abnormal_white_adipose1.88298426
28MP0004019_abnormal_vitamin_homeostasis1.86836589
29MP0002822_catalepsy1.82075152
30MP0003705_abnormal_hypodermis_morpholog1.78606191
31MP0005365_abnormal_bile_salt1.76229167
32MP0003806_abnormal_nucleotide_metabolis1.66870143
33MP0002277_abnormal_respiratory_mucosa1.60076156
34MP0006054_spinal_hemorrhage1.57443747
35MP0000538_abnormal_urinary_bladder1.46283876
36MP0002796_impaired_skin_barrier1.46003126
37MP0004147_increased_porphyrin_level1.45735634
38MP0008004_abnormal_stomach_pH1.44327655
39MP0003724_increased_susceptibility_to1.44252532
40MP0008872_abnormal_physiological_respon1.42618991
41MP0005409_darkened_coat_color1.39387456
42MP0004043_abnormal_pH_regulation1.39096628
43MP0003303_peritoneal_inflammation1.38253137
44MP0001849_ear_inflammation1.37124539
45MP0001765_abnormal_ion_homeostasis1.33781613
46MP0000230_abnormal_systemic_arterial1.31717196
47MP0009643_abnormal_urine_homeostasis1.25968981
48MP0005377_hearing/vestibular/ear_phenot1.25545517
49MP0003878_abnormal_ear_physiology1.25545517
50MP0002132_abnormal_respiratory_system1.24569171
51MP0005636_abnormal_mineral_homeostasis1.18678822
52MP0005448_abnormal_energy_balance1.15946771
53MP0003567_abnormal_fetal_cardiomyocyte1.13934003
54MP0004947_skin_inflammation1.11988648
55MP0000467_abnormal_esophagus_morphology1.11409182
56MP0002006_tumorigenesis1.10960649
57MP0000465_gastrointestinal_hemorrhage1.10135516
58MP0005166_decreased_susceptibility_to1.09671211
59MP0002089_abnormal_postnatal_growth/wei1.08954547
60MP0005451_abnormal_body_composition1.02336751
61MP0003693_abnormal_embryo_hatching1.02078864
62MP0000566_synostosis1.00570043
63MP0002163_abnormal_gland_morphology1.00570000
64MP0005332_abnormal_amino_acid0.98858729
65MP0005319_abnormal_enzyme/_coenzyme0.95563934
66MP0001188_hyperpigmentation0.95000445
67MP0010678_abnormal_skin_adnexa0.93609621
68MP0009785_altered_susceptibility_to0.92129466
69MP0005084_abnormal_gallbladder_morpholo0.90299096
70MP0000470_abnormal_stomach_morphology0.89818830
71MP0005165_increased_susceptibility_to0.89780895
72MP0009780_abnormal_chondrocyte_physiolo0.89364875
73MP0001764_abnormal_homeostasis0.88626417
74MP0009697_abnormal_copulation0.88299288
75MP0003868_abnormal_feces_composition0.86238813
76MP0001727_abnormal_embryo_implantation0.82507200
77MP0004957_abnormal_blastocyst_morpholog0.81791515
78MP0006082_CNS_inflammation0.81659639
79MP0002009_preneoplasia0.81230852
80MP0005666_abnormal_adipose_tissue0.80521590
81MP0004270_analgesia0.78860990
82MP0002876_abnormal_thyroid_physiology0.78493316
83MP0003191_abnormal_cellular_cholesterol0.77741613
84MP0001485_abnormal_pinna_reflex0.77740602
85MP0000609_abnormal_liver_physiology0.77454006
86MP0002098_abnormal_vibrissa_morphology0.77442935
87MP0002118_abnormal_lipid_homeostasis0.76680213
88MP0005501_abnormal_skin_physiology0.76084991
89MP0005266_abnormal_metabolism0.74794036
90MP0005187_abnormal_penis_morphology0.74309427
91MP0005257_abnormal_intraocular_pressure0.74120061
92MP0003718_maternal_effect0.74019386
93MP0005058_abnormal_lysosome_morphology0.72753154
94MP0002136_abnormal_kidney_physiology0.72110189
95MP0002896_abnormal_bone_mineralization0.70725959
96MP0003453_abnormal_keratinocyte_physiol0.70360631
97MP0001756_abnormal_urination0.70150223
98MP0004484_altered_response_of0.69473593
99MP0009384_cardiac_valve_regurgitation0.69011408
100MP0003315_abnormal_perineum_morphology0.68923921
101MP0000377_abnormal_hair_follicle0.67686667
102MP0005025_abnormal_response_to0.66741620
103MP0002254_reproductive_system_inflammat0.66281428
104MP0009053_abnormal_anal_canal0.65953462
105MP0009333_abnormal_splenocyte_physiolog0.65110796
106MP0000613_abnormal_salivary_gland0.65063527
107MP0005167_abnormal_blood-brain_barrier0.64565024
108MP0002060_abnormal_skin_morphology0.63472155
109MP0005584_abnormal_enzyme/coenzyme_acti0.63179592
110MP0001216_abnormal_epidermal_layer0.58824010
111MP0005023_abnormal_wound_healing0.58720678
112MP0004185_abnormal_adipocyte_glucose0.55540613
113MP0002932_abnormal_joint_morphology0.54871197
114MP0005376_homeostasis/metabolism_phenot0.54595805
115MP0004782_abnormal_surfactant_physiolog0.53936510
116MP0005408_hypopigmentation0.53492980
117MP0002166_altered_tumor_susceptibility0.52646213
118MP0005595_abnormal_vascular_smooth0.52000018
119MP0009642_abnormal_blood_homeostasis0.51320013
120MP0002148_abnormal_hypersensitivity_rea0.51174479
121MP0008873_increased_physiological_sensi0.51029163
122MP0002971_abnormal_brown_adipose0.50625015
123MP0001845_abnormal_inflammatory_respons0.50160727
124MP0003045_fibrosis0.50030281
125MP0005310_abnormal_salivary_gland0.49899334
126MP0005174_abnormal_tail_pigmentation0.49339724
127MP0003879_abnormal_hair_cell0.47892529
128MP0003953_abnormal_hormone_level0.47619382
129MP0000678_abnormal_parathyroid_gland0.46236801
130MP0000762_abnormal_tongue_morphology0.45654104
131MP0010307_abnormal_tumor_latency0.45454191
132MP0009115_abnormal_fat_cell0.45145916
133MP0005076_abnormal_cell_differentiation0.43784925
134MP0001533_abnormal_skeleton_physiology0.42178773

Predicted human phenotypes

RankGene SetZ-score
1Hyperaldosteronism (HP:0000859)6.16309503
2Hyponatremia (HP:0002902)5.21323167
3Right ventricular cardiomyopathy (HP:0011663)5.19937104
4Neonatal short-limb short stature (HP:0008921)5.15857064
5Flat capital femoral epiphysis (HP:0003370)4.85955544
6Abnormality of glutamine family amino acid metabolism (HP:0010902)4.72829540
7Flattened epiphyses (HP:0003071)4.65261206
8Hypokalemia (HP:0002900)4.49796351
9Abnormality of the distal phalanx of the thumb (HP:0009617)4.39203313
10Hypobetalipoproteinemia (HP:0003563)4.34294520
11Malnutrition (HP:0004395)4.32842846
12Ventricular fibrillation (HP:0001663)4.24461902
13Conjugated hyperbilirubinemia (HP:0002908)4.18172376
14Acanthocytosis (HP:0001927)4.17241848
15Abnormality of potassium homeostasis (HP:0011042)4.13599064
16Rectal prolapse (HP:0002035)4.05825224
17Abnormality of sodium homeostasis (HP:0010931)3.94638130
18Spinal cord compression (HP:0002176)3.80759507
19Breech presentation (HP:0001623)3.73676900
20Visceral angiomatosis (HP:0100761)3.65804371
21Abdominal distention (HP:0003270)3.65053050
22Hyperkalemia (HP:0002153)3.63457951
23Fat malabsorption (HP:0002630)3.62447184
24Autoimmune hemolytic anemia (HP:0001890)3.58228246
25Gastrointestinal dysmotility (HP:0002579)3.57084861
26Metabolic alkalosis (HP:0200114)3.48192190
27Increased muscle lipid content (HP:0009058)3.42918674
28Abnormal biliary tract morphology (HP:0012440)3.41491098
29Abnormality of urine glucose concentration (HP:0011016)3.37699138
30Glycosuria (HP:0003076)3.37699138
31Chronic diarrhea (HP:0002028)3.36577026
32Hemangiomatosis (HP:0007461)3.35314608
33Hydroxyprolinuria (HP:0003080)3.35008854
34Abnormality of proline metabolism (HP:0010907)3.35008854
35Vertebral hypoplasia (HP:0008417)3.32584115
36Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.32584115
37Increased intramyocellular lipid droplets (HP:0012240)3.29457435
38Adrenal overactivity (HP:0002717)3.29070498
39Abnormal tarsal ossification (HP:0008369)3.24187321
40Irregular epiphyses (HP:0010582)3.22873531
41Vertebral clefting (HP:0008428)3.21785278
42Large earlobe (HP:0009748)3.17637619
43Symphalangism affecting the phalanges of the hand (HP:0009773)3.16901717
44Congenital sensorineural hearing impairment (HP:0008527)3.12846771
45Cupped ribs (HP:0000887)3.08087457
46Widely patent fontanelles and sutures (HP:0004492)3.03391731
47Abnormal cartilage morphology (HP:0002763)3.02881807
48Abnormal vertebral ossification (HP:0100569)3.02650916
49Intrahepatic cholestasis (HP:0001406)2.99751216
50Abnormal hemoglobin (HP:0011902)2.95382278
51Hemorrhage of the eye (HP:0011885)2.94833511
52Woolly hair (HP:0002224)2.92507520
53Dehydration (HP:0001944)2.91262849
54Villous atrophy (HP:0011473)2.87578631
55Abnormality of small intestinal villus morphology (HP:0011472)2.87578631
56Pustule (HP:0200039)2.85767432
57Decreased circulating renin level (HP:0003351)2.78546272
58Mildly elevated creatine phosphokinase (HP:0008180)2.72401446
59Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.71149384
60Autoimmune thrombocytopenia (HP:0001973)2.65373205
61Progressive sensorineural hearing impairment (HP:0000408)2.62798101
62Abnormality of chloride homeostasis (HP:0011422)2.59987882
63Biliary tract neoplasm (HP:0100574)2.58512274
64Hyperactive renin-angiotensin system (HP:0000841)2.58110375
65Abnormality of the 1st metacarpal (HP:0010009)2.57285201
66Male infertility (HP:0003251)2.57162701
67Micronodular cirrhosis (HP:0001413)2.56124472
68Palpitations (HP:0001962)2.54488641
69Abnormality of the vitamin B12 metabolism (HP:0004341)2.52996733
70Lipid accumulation in hepatocytes (HP:0006561)2.52461990
71Abnormality of carpal bone ossification (HP:0006257)2.49832809
72Pigmentary retinal degeneration (HP:0001146)2.47302120
73Syncope (HP:0001279)2.44266681
74Macrocytic anemia (HP:0001972)2.43536550
75Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.38610412
76Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.37748131
77Abnormality of monocarboxylic acid metabolism (HP:0010996)2.35806156
78Sensory axonal neuropathy (HP:0003390)2.35519881
79Cheilitis (HP:0100825)2.35426700
80Abnormality of vitamin B metabolism (HP:0004340)2.34938904
81Hypolipoproteinemia (HP:0010981)2.33369803
82Hyperphosphaturia (HP:0003109)2.31817931
83Wide cranial sutures (HP:0010537)2.31221846
84Hoarse voice (HP:0001609)2.29543745
85Abnormality of the gastric mucosa (HP:0004295)2.29190146
86Milia (HP:0001056)2.29185521
87Hyperglycinuria (HP:0003108)2.28661506
88Aplasia/hypoplasia of the femur (HP:0005613)2.28213427
89Short middle phalanx of finger (HP:0005819)2.27230414
90Abnormal hair laboratory examination (HP:0003328)2.24788063
91Increased hepatocellular lipid droplets (HP:0006565)2.23799522
92Abnormality of renin-angiotensin system (HP:0000847)2.17629280
93Hip contracture (HP:0003273)2.17527124
94Ventricular arrhythmia (HP:0004308)2.15996540
95Progressive hearing impairment (HP:0001730)2.14982407
96Conjunctival hamartoma (HP:0100780)2.14929995
97Abnormal foot bone ossification (HP:0010675)2.14507396
98Abnormality of dicarboxylic acid metabolism (HP:0010995)2.13281600
99Poikilocytosis (HP:0004447)2.12249484
100Chronic bronchitis (HP:0004469)2.09633736
101Abnormal urine phosphate concentration (HP:0012599)2.09441265
102Pili torti (HP:0003777)2.05408947
103Subacute progressive viral hepatitis (HP:0006572)2.04265350
104Hyperparathyroidism (HP:0000843)2.03476720
105Abnormality of vitamin metabolism (HP:0100508)2.02596242
106Symptomatic seizures (HP:0011145)2.02060818
107Nausea (HP:0002018)2.01215275
108Alkalosis (HP:0001948)2.00525151
109Premature loss of primary teeth (HP:0006323)2.00380834
110Fragile skin (HP:0001030)2.00290711
111Goiter (HP:0000853)2.00275526
112Renal tubular acidosis (HP:0001947)2.00033494
113Ileus (HP:0002595)10.1922013
114Abnormality of fatty-acid metabolism (HP:0004359)1.99518790
115Onycholysis (HP:0001806)1.97849642
116Hyperammonemia (HP:0001987)1.97691504
117Neoplasm of the rectum (HP:0100743)1.97114065
118Increased density of long bones (HP:0006392)1.93901933
119Fragile nails (HP:0001808)1.93428120
120Flat acetabular roof (HP:0003180)1.93157081
121Facial shape deformation (HP:0011334)1.92972246
122Potter facies (HP:0002009)1.92972246
123Thin bony cortex (HP:0002753)1.92448307
124Abnormal hand bone ossification (HP:0010660)1.92235721
125Stillbirth (HP:0003826)1.91131527
126Increased mean platelet volume (HP:0011877)1.90989224
127Hip dysplasia (HP:0001385)1.90431376
128Plantar hyperkeratosis (HP:0007556)1.90099254
129Polygenic inheritance (HP:0010982)1.89733490
130Hypoglycemic coma (HP:0001325)1.89711491
131Abnormal ossification of hand bones (HP:0005921)1.88678945
132Short phalanx of the thumb (HP:0009660)1.88356813
133Petechiae (HP:0000967)1.88298272
134Bone cyst (HP:0012062)1.87482870
135Proximal tubulopathy (HP:0000114)1.85389268
136Neoplasm of the small intestine (HP:0100833)1.82559568
137Hepatic necrosis (HP:0002605)1.80687738
138Sensorimotor neuropathy (HP:0007141)1.80230645
139Abnormality of the right ventricle (HP:0001707)1.80045336
140Nonimmune hydrops fetalis (HP:0001790)1.79836218
141Ankyloglossia (HP:0010296)1.79747975
142Abnormality of B cell number (HP:0010975)1.79078005
143B lymphocytopenia (HP:0010976)1.79078005
144Dicarboxylic aciduria (HP:0003215)1.78214065
145Abnormality of the acetabulum (HP:0003170)1.77487884
146Renal salt wasting (HP:0000127)1.73356296
147Curly hair (HP:0002212)1.72373781
148Severe short stature (HP:0003510)1.72238748
149Bundle branch block (HP:0011710)1.71485975
150Cerebral hemorrhage (HP:0001342)1.68379384
151Hypotension (HP:0002615)1.63738935
152Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.62168301
153Cone-rod dystrophy (HP:0000548)1.60379654
154Abnormality of the phalanges of the hallux (HP:0010057)1.60225635
155Late onset (HP:0003584)1.58705988
156Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.58206517
157Eczematoid dermatitis (HP:0000976)1.56466535
158Deviation of the thumb (HP:0009603)1.53783233
159Proximal placement of thumb (HP:0009623)1.53072306
160Tracheal stenosis (HP:0002777)1.48735112
161Protuberant abdomen (HP:0001538)1.47061711
162Abnormality of the epiphysis of the femoral head (HP:0010574)1.46487753
163Abnormality of magnesium homeostasis (HP:0004921)1.44233189

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK28.11538767
2FRK6.73658916
3ACVR1B5.84087405
4MST1R4.34126968
5PRKG23.62187744
6MST43.31529840
7NUAK12.95325654
8NME12.73279695
9MAP2K62.65924384
10MAP2K22.30622133
11MAP3K21.97512856
12TESK11.87902516
13EPHA21.72880596
14STK241.65969431
15ERN11.62696681
16GRK61.54537090
17TESK21.53268955
18STK391.53129554
19KSR21.46216067
20PTK61.45914430
21MET1.45885469
22RIPK11.43910191
23EPHB21.38638188
24PBK1.31452335
25PIK3CA1.25518837
26PDK21.25202251
27MAP3K101.21049895
28ERBB21.19500461
29TTK1.17091717
30MYLK1.05854555
31AKT31.01011846
32STK160.99873113
33PRKCI0.90660624
34PDPK10.90580315
35MUSK0.89412375
36PRPF4B0.80572103
37STK100.78685681
38TBK10.77679226
39ARAF0.76434878
40TAOK30.75010174
41LATS10.74421158
42MAP3K120.72466838
43MAP2K10.72117224
44PAK40.70020742
45MAP3K80.68783619
46WNK40.67857042
47MAP3K110.67647741
48AURKB0.67048639
49FER0.65833157
50PRKAA20.64988893
51MAP3K70.64233411
52MAPKAPK30.63307336
53SCYL20.62798048
54PDK10.61708120
55PAK30.61600589
56CDK190.60475132
57DMPK0.60381405
58BMX0.59364838
59PTK20.57936243
60MATK0.57073801
61SMG10.56533546
62EPHB10.56270359
63OXSR10.54661143
64MAP3K10.54652806
65PIM20.54395633
66NEK10.54300831
67DYRK1B0.52028970
68DDR20.50981981
69NME20.50157282
70TAOK10.49054248
71IRAK30.48283807
72MAP3K90.44944796
73TYK20.44471010
74LIMK10.42543671
75TNIK0.42339236
76CSNK1A10.41601296
77MAPKAPK20.40656856
78PRKCA0.40386257
79FGFR40.39280283
80LRRK20.38873068
81EPHA40.38784429
82CAMK2G0.37202442
83IKBKE0.36400534
84CAMK2D0.36219420
85GRK10.36163617
86PRKAA10.35602631
87CDK120.34537290
88CDC42BPA0.33992287
89PAK10.33492366
90PDK40.30869736
91PDK30.30869736
92NEK90.30793643
93RPS6KA20.29930232
94TRIB30.29370671
95RIPK40.29349790
96ROCK10.28123652
97SRC0.27673333
98RPS6KA10.26561828
99YES10.25940452
100CCNB10.25248839
101FGFR30.24925624
102CAMK2B0.24734743
103MAPK110.24425373
104ABL20.24166248
105PHKG10.24054792
106PHKG20.24054792
107PKN20.22197882
108MAPK150.21794483
109RET0.21581867
110WNK10.21471546
111MAP3K140.20571227
112CAMKK10.20431192
113PRKCQ0.20240955
114AKT20.20127077
115EPHA30.19630816
116CSK0.18943360
117NLK0.18889788
118MAP3K30.18646902
119LYN0.18330000
120PASK0.18242931
121VRK10.17701086
122RAF10.17609506
123PRKACG0.17301850
124FYN0.16627669
125RPS6KC10.15836844
126RPS6KL10.15836844
127JAK20.13888257
128ZAP700.13836751
129RPS6KB10.11829923
130PRKCD0.11631182
131PRKCB0.10184003
132RPS6KA60.09661589
133CASK0.08393230
134MAP4K10.08034917
135IGF1R0.06626613
136CDK90.05431387

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049754.64408685
2Sulfur metabolism_Homo sapiens_hsa009204.54562091
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.85784999
4Mineral absorption_Homo sapiens_hsa049783.29560464
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.10908868
6Renin-angiotensin system_Homo sapiens_hsa046142.73611507
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.53331715
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.50216784
9Fructose and mannose metabolism_Homo sapiens_hsa000512.40858939
10Vitamin digestion and absorption_Homo sapiens_hsa049772.29160475
11Galactose metabolism_Homo sapiens_hsa000522.26933220
12Cyanoamino acid metabolism_Homo sapiens_hsa004601.91415496
13Carbohydrate digestion and absorption_Homo sapiens_hsa049731.91372632
14Bile secretion_Homo sapiens_hsa049761.90904517
15Pentose and glucuronate interconversions_Homo sapiens_hsa000401.87368214
16Starch and sucrose metabolism_Homo sapiens_hsa005001.86470400
17Caffeine metabolism_Homo sapiens_hsa002321.85244868
18Folate biosynthesis_Homo sapiens_hsa007901.84149542
19Nitrogen metabolism_Homo sapiens_hsa009101.82382402
20Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.77974535
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.75527041
22Histidine metabolism_Homo sapiens_hsa003401.69537162
23Butanoate metabolism_Homo sapiens_hsa006501.62094897
24Glutathione metabolism_Homo sapiens_hsa004801.54606226
25Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.53325514
26Ribosome_Homo sapiens_hsa030101.53205659
27Oxidative phosphorylation_Homo sapiens_hsa001901.52869988
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.48390226
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.46443308
30Protein digestion and absorption_Homo sapiens_hsa049741.45402512
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.34525211
32Parkinsons disease_Homo sapiens_hsa050121.32346899
33Tryptophan metabolism_Homo sapiens_hsa003801.31429768
34Fatty acid degradation_Homo sapiens_hsa000711.28905111
35Pentose phosphate pathway_Homo sapiens_hsa000301.28671986
36Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.24218657
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.23686207
38Other glycan degradation_Homo sapiens_hsa005111.23018891
39Alzheimers disease_Homo sapiens_hsa050101.19988230
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.18787185
41Arginine biosynthesis_Homo sapiens_hsa002201.18196319
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.15153088
43Carbon metabolism_Homo sapiens_hsa012001.12044622
44Chemical carcinogenesis_Homo sapiens_hsa052041.09234452
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.09167253
46Glycerolipid metabolism_Homo sapiens_hsa005611.03364095
47PPAR signaling pathway_Homo sapiens_hsa033201.00773384
48Linoleic acid metabolism_Homo sapiens_hsa005910.98714894
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97867247
50Pancreatic secretion_Homo sapiens_hsa049720.94764950
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94590207
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91429054
53Huntingtons disease_Homo sapiens_hsa050160.89872490
54Tight junction_Homo sapiens_hsa045300.86638095
55Sulfur relay system_Homo sapiens_hsa041220.85961940
56Arginine and proline metabolism_Homo sapiens_hsa003300.84209462
57Retinol metabolism_Homo sapiens_hsa008300.73741660
58Pyruvate metabolism_Homo sapiens_hsa006200.68835316
59Thyroid hormone synthesis_Homo sapiens_hsa049180.68173429
60Arachidonic acid metabolism_Homo sapiens_hsa005900.67625854
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63696943
62Drug metabolism - other enzymes_Homo sapiens_hsa009830.62446110
63Cardiac muscle contraction_Homo sapiens_hsa042600.60787455
64Tyrosine metabolism_Homo sapiens_hsa003500.60450712
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.60306091
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60197862
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.59224912
68Gastric acid secretion_Homo sapiens_hsa049710.51077948
69ABC transporters_Homo sapiens_hsa020100.50777337
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50725831
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50300712
72Leukocyte transendothelial migration_Homo sapiens_hsa046700.48828390
73Salmonella infection_Homo sapiens_hsa051320.47965606
74Biosynthesis of amino acids_Homo sapiens_hsa012300.47141142
75Metabolic pathways_Homo sapiens_hsa011000.44489719
76Renin secretion_Homo sapiens_hsa049240.43800454
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43644614
78Sphingolipid metabolism_Homo sapiens_hsa006000.43612499
79beta-Alanine metabolism_Homo sapiens_hsa004100.43223011
80Ether lipid metabolism_Homo sapiens_hsa005650.41893495
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.39684614
82Salivary secretion_Homo sapiens_hsa049700.37380848
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.36873019
84Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.34739723
85Peroxisome_Homo sapiens_hsa041460.34596177
86Hepatitis C_Homo sapiens_hsa051600.30472012
87Fatty acid metabolism_Homo sapiens_hsa012120.30161201
88Fatty acid elongation_Homo sapiens_hsa000620.29784622
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29695328
90Vibrio cholerae infection_Homo sapiens_hsa051100.28305793
91Intestinal immune network for IgA production_Homo sapiens_hsa046720.25814142
92Pertussis_Homo sapiens_hsa051330.24704688
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.24268397
94Type II diabetes mellitus_Homo sapiens_hsa049300.23878054
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.23310104
96Primary bile acid biosynthesis_Homo sapiens_hsa001200.22526219
97African trypanosomiasis_Homo sapiens_hsa051430.21812330
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.18173055
99Adherens junction_Homo sapiens_hsa045200.16543743
100Bladder cancer_Homo sapiens_hsa052190.15153945
101Propanoate metabolism_Homo sapiens_hsa006400.14959858
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.14945921
103Selenocompound metabolism_Homo sapiens_hsa004500.14798495
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.13732940
105Allograft rejection_Homo sapiens_hsa053300.12485134
106Thyroid cancer_Homo sapiens_hsa052160.11630233
107Phenylalanine metabolism_Homo sapiens_hsa003600.11354528
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.10822036
109Autoimmune thyroid disease_Homo sapiens_hsa053200.10528314
110Collecting duct acid secretion_Homo sapiens_hsa049660.10072671
111Leishmaniasis_Homo sapiens_hsa051400.09648115
112Insulin resistance_Homo sapiens_hsa049310.08712698
113Graft-versus-host disease_Homo sapiens_hsa053320.08092096
114Influenza A_Homo sapiens_hsa051640.07929739
115Legionellosis_Homo sapiens_hsa051340.07825865
116Choline metabolism in cancer_Homo sapiens_hsa052310.07354834
117Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.06634844
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.05340210
119Endocytosis_Homo sapiens_hsa041440.04714339
120Asthma_Homo sapiens_hsa053100.04270520
121Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.04012769
122GnRH signaling pathway_Homo sapiens_hsa049120.01093269
123AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933-0.0480709
124Shigellosis_Homo sapiens_hsa05131-0.0414869
125Adipocytokine signaling pathway_Homo sapiens_hsa04920-0.0300686
126Type I diabetes mellitus_Homo sapiens_hsa04940-0.0215624
127Phosphatidylinositol signaling system_Homo sapiens_hsa04070-0.0147059
128Inositol phosphate metabolism_Homo sapiens_hsa00562-0.0072007

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