MS4A13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.29937708
2motile cilium assembly (GO:0044458)9.27774239
3cilium movement (GO:0003341)8.55483717
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.11985501
5male meiosis (GO:0007140)8.09889756
6piRNA metabolic process (GO:0034587)8.03025669
7regulation of cilium movement (GO:0003352)7.78596887
8single fertilization (GO:0007338)7.71508834
9synaptonemal complex organization (GO:0070193)7.59309390
10synaptonemal complex assembly (GO:0007130)7.50831878
11sperm capacitation (GO:0048240)7.41029406
12fertilization (GO:0009566)6.39690168
13spermatogenesis (GO:0007283)6.12931240
14negative regulation of inclusion body assembly (GO:0090084)6.11883145
15male gamete generation (GO:0048232)6.10784723
16microtubule depolymerization (GO:0007019)5.74518403
17spermatid nucleus differentiation (GO:0007289)5.73373582
18organic cation transport (GO:0015695)5.63556185
19gamete generation (GO:0007276)5.61814439
20ventricular system development (GO:0021591)5.34713072
21cellular process involved in reproduction in multicellular organism (GO:0022412)5.30863187
22chromosome organization involved in meiosis (GO:0070192)5.24452326
23germ cell development (GO:0007281)5.22288561
24calcium ion-dependent exocytosis (GO:0017156)5.20499835
25cell recognition (GO:0008037)5.18133273
26DNA methylation involved in gamete generation (GO:0043046)5.15703903
27regulation of inclusion body assembly (GO:0090083)5.12175103
28male meiosis I (GO:0007141)4.87631029
29microtubule severing (GO:0051013)4.81755469
30meiotic nuclear division (GO:0007126)4.61806146
31regulation of microtubule-based movement (GO:0060632)4.55575024
32multicellular organismal reproductive process (GO:0048609)4.41125659
33seminiferous tubule development (GO:0072520)4.32191223
34glycerol ether metabolic process (GO:0006662)4.31061812
35monoubiquitinated protein deubiquitination (GO:0035520)4.19066679
36ether metabolic process (GO:0018904)3.98357393
37meiosis I (GO:0007127)3.88297597
38single strand break repair (GO:0000012)3.84966295
39sexual reproduction (GO:0019953)3.84928532
40chromosome condensation (GO:0030261)3.81448290
41left/right pattern formation (GO:0060972)3.76765949
42chaperone-mediated protein complex assembly (GO:0051131)3.76265673
43protein K11-linked deubiquitination (GO:0035871)3.74197003
44genitalia morphogenesis (GO:0035112)3.69474245
45DNA packaging (GO:0006323)3.62437820
46protein polyglutamylation (GO:0018095)3.62353669
47meiotic cell cycle (GO:0051321)3.58750555
48multicellular organismal development (GO:0007275)3.57789571
49protein localization to cilium (GO:0061512)3.52165432
50intraciliary transport (GO:0042073)3.20230037
51synapsis (GO:0007129)3.15128897
52carnitine transport (GO:0015879)3.05876478
53amino-acid betaine transport (GO:0015838)3.05876478
54microtubule-based movement (GO:0007018)3.05455857
55centriole assembly (GO:0098534)3.04924867
56cilium organization (GO:0044782)3.02189731
57alditol metabolic process (GO:0019400)2.99970798
58microtubule polymerization or depolymerization (GO:0031109)2.97280848
59carnitine transmembrane transport (GO:1902603)2.96711301
60regulation of spindle checkpoint (GO:0090231)2.95379502
61polyol catabolic process (GO:0046174)2.94916629
62gene silencing by RNA (GO:0031047)2.94229302
63lactate metabolic process (GO:0006089)2.94219717
64meiotic cell cycle process (GO:1903046)2.93126277
65sequestering of actin monomers (GO:0042989)2.92627962
66nucleoside diphosphate phosphorylation (GO:0006165)2.91357829
67centriole replication (GO:0007099)2.89488791
68glycolytic process (GO:0006096)2.89483259
69cilium assembly (GO:0042384)2.89241154
70cellular component assembly involved in morphogenesis (GO:0010927)2.88948428
71protein refolding (GO:0042026)2.87022663
72axoneme assembly (GO:0035082)2.86920350
73negative regulation of organelle assembly (GO:1902116)2.83581444
74nucleus organization (GO:0006997)2.82921987
75GTP biosynthetic process (GO:0006183)2.77979310
76regulation of centriole replication (GO:0046599)2.75080543
77cilium morphogenesis (GO:0060271)2.73590314
78positive regulation of macrophage activation (GO:0043032)2.71165951
79glycerol metabolic process (GO:0006071)2.65062382
80mitotic sister chromatid cohesion (GO:0007064)2.58606341
81nuclear pore complex assembly (GO:0051292)2.47810578
82UTP biosynthetic process (GO:0006228)2.47091310
83peptidyl-glutamic acid modification (GO:0018200)2.41655869
84gene silencing (GO:0016458)2.40934376
85interferon-gamma secretion (GO:0072643)2.38322152
86fusion of sperm to egg plasma membrane (GO:0007342)14.3380765
87cell wall macromolecule catabolic process (GO:0016998)14.0507732
88cell wall macromolecule metabolic process (GO:0044036)14.0507732
89sperm motility (GO:0030317)13.0607416
90acrosome assembly (GO:0001675)12.6567384
91cilium or flagellum-dependent cell motility (GO:0001539)12.2945914
92multicellular organism reproduction (GO:0032504)11.9714967
93sperm-egg recognition (GO:0035036)11.8945718
94plasma membrane fusion (GO:0045026)10.9334119
95acrosome reaction (GO:0007340)10.9257436
96cell-cell recognition (GO:0009988)10.6645073
97binding of sperm to zona pellucida (GO:0007339)10.6372978
98axonemal dynein complex assembly (GO:0070286)10.3362666
99reproduction (GO:0000003)10.1665608
100epithelial cilium movement (GO:0003351)10.0783698

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.86536709
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.84099685
3EZH2_22144423_ChIP-Seq_EOC_Human4.02686137
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.58999526
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.07878170
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.66161563
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.60536581
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.37215931
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.35132773
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.18152985
11ZNF274_21170338_ChIP-Seq_K562_Hela2.07906452
12EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.05179478
13CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.03969392
14VDR_22108803_ChIP-Seq_LS180_Human2.02890432
15KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse2.00791646
16CBX2_27304074_Chip-Seq_ESCs_Mouse1.99535652
17STAT6_21828071_ChIP-Seq_BEAS2B_Human1.94013427
18RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.88744871
19TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.84206120
20KAP1_22055183_ChIP-Seq_ESCs_Mouse1.81579938
21GATA1_26923725_Chip-Seq_HPCs_Mouse1.80536154
22PCGF2_27294783_Chip-Seq_NPCs_Mouse1.77945104
23ELK4_26923725_Chip-Seq_MESODERM_Mouse1.67344269
24GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.65265224
25KDM2B_26808549_Chip-Seq_REH_Human1.63568118
26* STAT1_17558387_ChIP-Seq_HELA_Human1.62398305
27TAL1_26923725_Chip-Seq_HPCs_Mouse1.61942613
28NFE2_27457419_Chip-Seq_LIVER_Mouse1.61818303
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57984361
30SUZ12_27294783_Chip-Seq_NPCs_Mouse1.57576479
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.55599260
32TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.51450733
33WDR5_24793694_ChIP-Seq_LNCAP_Human1.49631412
34MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.48909235
35GATA3_21867929_ChIP-Seq_CD8_Mouse1.47809716
36FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46366774
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43825047
38CBP_20019798_ChIP-Seq_JUKART_Human1.43825047
39SOX2_22085726_ChIP-Seq_NPCs_Mouse1.40926525
40FLI1_21867929_ChIP-Seq_TH2_Mouse1.37661556
41NANOG_18555785_Chip-Seq_ESCs_Mouse1.34386634
42CRX_20693478_ChIP-Seq_RETINA_Mouse1.34381032
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32513155
44EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.32379642
45LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.31550594
46GATA3_21867929_ChIP-Seq_TH1_Mouse1.30860385
47OCT4_18555785_Chip-Seq_ESCs_Mouse1.30835603
48P53_22387025_ChIP-Seq_ESCs_Mouse1.24671742
49CMYC_18555785_Chip-Seq_ESCs_Mouse1.24310245
50REST_21632747_ChIP-Seq_MESCs_Mouse1.23928787
51TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22341639
52P300_18555785_Chip-Seq_ESCs_Mouse1.21575919
53CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21511415
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.20901975
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20135945
56RNF2_27304074_Chip-Seq_NSC_Mouse1.19664928
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18614498
58KLF4_18555785_Chip-Seq_ESCs_Mouse1.18023800
59GF1_26923725_Chip-Seq_HPCs_Mouse1.17055159
60PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.16926695
61SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.15863639
62EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.15436991
63P53_21459846_ChIP-Seq_SAOS-2_Human1.15146880
64POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14759106
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14759106
66ESRRB_18555785_Chip-Seq_ESCs_Mouse1.14313783
67OCT4_21477851_ChIP-Seq_ESCs_Mouse1.14059691
68CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13160064
69SUZ12_18555785_Chip-Seq_ESCs_Mouse1.13157173
70RUNX1_26923725_Chip-Seq_HPCs_Mouse1.10691060
71STAT3_18555785_Chip-Seq_ESCs_Mouse1.09532868
72FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07389696
73* SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.05960900
74EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05465565
75SOX2_18555785_Chip-Seq_ESCs_Mouse1.05394745
76SPI1_26923725_Chip-Seq_HPCs_Mouse1.02284917
77CTCF_18555785_Chip-Seq_ESCs_Mouse1.01785910
78RAD21_21589869_ChIP-Seq_MESCs_Mouse1.01061864
79RUNX1_27457419_Chip-Seq_LIVER_Mouse1.00564953
80PU1_27457419_Chip-Seq_LIVER_Mouse1.00454325
81E2F1_18555785_Chip-Seq_ESCs_Mouse0.99330226
82TAF15_26573619_Chip-Seq_HEK293_Human0.97999112
83PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97009301
84SOX9_26525672_Chip-Seq_HEART_Mouse0.96366905
85EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.95361350
86NMYC_18555785_Chip-Seq_ESCs_Mouse0.94809761
87PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94742719
88* ESET_19884257_ChIP-Seq_ESCs_Mouse0.94730638
89SMAD1_18555785_Chip-Seq_ESCs_Mouse0.94572601
90GF1B_26923725_Chip-Seq_HPCs_Mouse0.94114111
91CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92793739
92CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.92078645
93ZFX_18555785_Chip-Seq_ESCs_Mouse0.91711822
94LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.91090465
95PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.90896995
96ERG_20517297_ChIP-Seq_VCAP_Human0.90669329
97RARA_24833708_ChIP-Seq_LIVER_Mouse0.90605208
98NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.87574347
99GATA1_19941827_ChIP-Seq_MEL86_Mouse0.87222239
100KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.86702383

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.15759256
2MP0001929_abnormal_gametogenesis5.64493498
3MP0008877_abnormal_DNA_methylation4.70890445
4MP0002210_abnormal_sex_determination3.67204592
5MP0002161_abnormal_fertility/fecundity3.31728634
6MP0001145_abnormal_male_reproductive3.11084431
7MP0002653_abnormal_ependyma_morphology3.10149441
8MP0000653_abnormal_sex_gland2.70834078
9MP0005670_abnormal_white_adipose2.19272735
10MP0005623_abnormal_meninges_morphology2.05303374
11MP0005410_abnormal_fertilization15.9422495
12MP0002160_abnormal_reproductive_system1.59764567
13MP0008058_abnormal_DNA_repair1.43429311
14MP0009046_muscle_twitch1.38863910
15MP0004233_abnormal_muscle_weight1.38686428
16MP0002282_abnormal_trachea_morphology1.35951528
17MP0003646_muscle_fatigue1.23607277
18MP0008057_abnormal_DNA_replication1.21420816
19MP0005647_abnormal_sex_gland1.12804905
20MP0001765_abnormal_ion_homeostasis1.12204740
21MP0001984_abnormal_olfaction1.06674154
22MP0010094_abnormal_chromosome_stability0.89459146
23MP0005389_reproductive_system_phenotype0.83518889
24MP0003011_delayed_dark_adaptation0.82624887
25MP0002234_abnormal_pharynx_morphology0.80113034
26MP0008995_early_reproductive_senescence0.70438825
27MP0002928_abnormal_bile_duct0.59764648
28MP0005636_abnormal_mineral_homeostasis0.58975245
29MP0002102_abnormal_ear_morphology0.55446141
30MP0003950_abnormal_plasma_membrane0.53648360
31MP0000358_abnormal_cell_content/0.51212827
32MP0004036_abnormal_muscle_relaxation0.50950725
33MP0003699_abnormal_female_reproductive0.50119953
34MP0000569_abnormal_digit_pigmentation0.49674681
35MP0001324_abnormal_eye_pigmentation0.48760567
36MP0003786_premature_aging0.48166265
37MP0005377_hearing/vestibular/ear_phenot0.46824935
38MP0003878_abnormal_ear_physiology0.46824935
39MP0005551_abnormal_eye_electrophysiolog0.46165912
40MP0003115_abnormal_respiratory_system0.45702072
41MP0001293_anophthalmia0.44191202
42MP0008007_abnormal_cellular_replicative0.44142065
43MP0004019_abnormal_vitamin_homeostasis0.43822491
44MP0005253_abnormal_eye_physiology0.42677359
45MP0001119_abnormal_female_reproductive0.42459874
46MP0010307_abnormal_tumor_latency0.41646124
47MP0001764_abnormal_homeostasis0.39228420
48MP0002269_muscular_atrophy0.38474594
49MP0005666_abnormal_adipose_tissue0.37707009
50MP0001545_abnormal_hematopoietic_system0.37139415
51MP0005397_hematopoietic_system_phenotyp0.37139415
52MP0006036_abnormal_mitochondrial_physio0.36463370
53MP0003633_abnormal_nervous_system0.35483074
54MP0004133_heterotaxia0.35450566
55MP0003111_abnormal_nucleus_morphology0.34041914
56MP0004134_abnormal_chest_morphology0.32387689
57MP0002971_abnormal_brown_adipose0.31820878
58MP0005391_vision/eye_phenotype0.31595979
59MP0002736_abnormal_nociception_after0.31040205
60MP0003329_amyloid_beta_deposits0.30907676
61MP0009115_abnormal_fat_cell0.30854532
62MP0002139_abnormal_hepatobiliary_system0.28353017
63MP0002132_abnormal_respiratory_system0.27361357
64MP0009278_abnormal_bone_marrow0.27226006
65MP0004808_abnormal_hematopoietic_stem0.26208414
66MP0001730_embryonic_growth_arrest0.24725285
67MP0003631_nervous_system_phenotype0.24177659
68MP0003861_abnormal_nervous_system0.23244674
69MP0004811_abnormal_neuron_physiology0.22539741
70MP0009697_abnormal_copulation0.21855484
71MP0002152_abnormal_brain_morphology0.21784367
72MP0000313_abnormal_cell_death0.21780642
73MP0000427_abnormal_hair_cycle0.21158056
74MP0004084_abnormal_cardiac_muscle0.19225488
75MP0002169_no_abnormal_phenotype0.16891152
76MP0002873_normal_phenotype0.16637099
77MP0006035_abnormal_mitochondrial_morpho0.16488114
78MP0004742_abnormal_vestibular_system0.16410191
79MP0006072_abnormal_retinal_apoptosis0.16404883
80MP0002084_abnormal_developmental_patter0.15819542
81MP0001968_abnormal_touch/_nociception0.15632469
82MP0005365_abnormal_bile_salt0.14755932
83MP0002229_neurodegeneration0.14706353
84MP0002092_abnormal_eye_morphology0.14608135
85MP0002405_respiratory_system_inflammati0.14458355
86MP0005195_abnormal_posterior_eye0.14395087
87MP0008875_abnormal_xenobiotic_pharmacok0.14381201
88MP0005319_abnormal_enzyme/_coenzyme0.14331279
89MP0004145_abnormal_muscle_electrophysio0.14070730
90MP0000604_amyloidosis0.13807440
91MP0000432_abnormal_head_morphology0.12782274
92MP0001727_abnormal_embryo_implantation0.11824020
93MP0000001_mammalian_phenotype0.11457618
94MP0005535_abnormal_body_temperature0.11124265
95MP0001919_abnormal_reproductive_system0.10715469
96MP0002133_abnormal_respiratory_system0.10416288
97MP0005388_respiratory_system_phenotype0.10416288
98MP0000534_abnormal_ureter_morphology0.10164722
99MP0003948_abnormal_gas_homeostasis0.10010985
100MP0008569_lethality_at_weaning0.09609199

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.76359461
2Abnormal respiratory epithelium morphology (HP:0012253)9.10014414
3Abnormal respiratory motile cilium morphology (HP:0005938)9.10014414
4Abnormal ciliary motility (HP:0012262)8.10596735
5Rhinitis (HP:0012384)7.83648732
6Chronic bronchitis (HP:0004469)7.50840491
7Nasal polyposis (HP:0100582)6.45298516
8Infertility (HP:0000789)6.28511932
9Abnormality of the nasal mucosa (HP:0000433)5.30016481
10Bronchiectasis (HP:0002110)4.60810693
11Bronchitis (HP:0012387)4.58615603
12Nephronophthisis (HP:0000090)4.17441193
13Male infertility (HP:0003251)3.82402793
14Recurrent sinusitis (HP:0011108)3.66196594
15Recurrent otitis media (HP:0000403)3.32260342
16Abnormal spermatogenesis (HP:0008669)3.26252253
17Abnormality of the renal medulla (HP:0100957)3.18133959
18Medial flaring of the eyebrow (HP:0010747)2.92307934
19Tubulointerstitial nephritis (HP:0001970)2.84544304
20Molar tooth sign on MRI (HP:0002419)2.71871232
21Abnormality of midbrain morphology (HP:0002418)2.71871232
22Recurrent bronchitis (HP:0002837)2.63799010
23Tubular atrophy (HP:0000092)2.49751288
24Azoospermia (HP:0000027)2.37917886
25Tubulointerstitial abnormality (HP:0001969)2.37564240
26Abnormality of the lower motor neuron (HP:0002366)2.24530552
27Gonadotropin excess (HP:0000837)2.24034817
28Postaxial foot polydactyly (HP:0001830)2.03387852
29Impulsivity (HP:0100710)2.02771064
30Fibular hypoplasia (HP:0003038)2.00128533
31Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.8519275
32Absent/shortened dynein arms (HP:0200106)13.0611571
33Dynein arm defect of respiratory motile cilia (HP:0012255)13.0611571
34Congenital hepatic fibrosis (HP:0002612)1.89190471
35Tubulointerstitial fibrosis (HP:0005576)1.86345431
36Chronic sinusitis (HP:0011109)1.85785269
37Congenital primary aphakia (HP:0007707)1.83580607
38Stage 5 chronic kidney disease (HP:0003774)1.83163987
39Gait imbalance (HP:0002141)1.83160345
40Amyotrophic lateral sclerosis (HP:0007354)1.80050629
41Abnormality of the renal cortex (HP:0011035)1.75416927
42Microglossia (HP:0000171)1.73638588
43Abnormal drinking behavior (HP:0030082)1.70094433
44Polydipsia (HP:0001959)1.70094433
45Facial cleft (HP:0002006)1.67345823
46Abnormality of the dental root (HP:0006486)1.65161105
47Taurodontia (HP:0000679)1.65161105
48Abnormality of permanent molar morphology (HP:0011071)1.65161105
49Pancreatic fibrosis (HP:0100732)1.63268453
50Hypoplasia of the capital femoral epiphysis (HP:0003090)1.63179634
51Postaxial hand polydactyly (HP:0001162)1.63133741
52Short ribs (HP:0000773)1.63129945
53Oculomotor apraxia (HP:0000657)1.61644983
54Dyschromatopsia (HP:0007641)1.61192600
55Cholecystitis (HP:0001082)1.58568982
56Abnormal gallbladder physiology (HP:0012438)1.58568982
57Abnormality of renal excretion (HP:0011036)1.58529393
58Decreased central vision (HP:0007663)1.56983487
59Nephrogenic diabetes insipidus (HP:0009806)1.56538040
60Renal dysplasia (HP:0000110)1.56203755
61Abnormality of molar (HP:0011077)1.55547756
62Abnormality of molar morphology (HP:0011070)1.55547756
63Absent frontal sinuses (HP:0002688)1.55135629
64Tongue fasciculations (HP:0001308)1.54441472
65Aplasia/Hypoplasia of the tongue (HP:0010295)1.52922722
66Abnormality of the dental pulp (HP:0006479)1.50846777
67Abnormal biliary tract physiology (HP:0012439)1.50818258
68Bile duct proliferation (HP:0001408)1.50818258
69Aplasia/Hypoplasia of the lens (HP:0008063)1.49655954
70Impaired proprioception (HP:0010831)1.47559952
71Cystic liver disease (HP:0006706)1.47320330
72Heterotopia (HP:0002282)1.47072695
73Spastic tetraparesis (HP:0001285)1.46633714
74Median cleft lip (HP:0000161)1.46087301
75J-shaped sella turcica (HP:0002680)1.45791842
76Supernumerary spleens (HP:0009799)1.44253087
77Abnormality of saccadic eye movements (HP:0000570)1.43836427
78Abnormality of dentin (HP:0010299)1.43537893
79Genital tract atresia (HP:0001827)1.40460592
80Abnormality of ocular smooth pursuit (HP:0000617)1.39940425
81Asymmetric septal hypertrophy (HP:0001670)1.39470591
82Muscle fibrillation (HP:0010546)1.39058308
83Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.37800606
84Vaginal atresia (HP:0000148)1.36625875
85Poor coordination (HP:0002370)1.36395843
86Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.36016687
87Bell-shaped thorax (HP:0001591)1.34536436
88Short thorax (HP:0010306)1.28227516
89True hermaphroditism (HP:0010459)1.28000586
90Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.27684529
91Absent epiphyses (HP:0010577)1.27684529
92Optic nerve hypoplasia (HP:0000609)1.25956071
93Deformed sella turcica (HP:0002681)1.25874961
94Aplasia/Hypoplasia of the fibula (HP:0006492)1.25446495
95Chronic hepatic failure (HP:0100626)1.25338889
96Vascular calcification (HP:0004934)1.22392079
97Nephropathy (HP:0000112)1.22050556
98Breast carcinoma (HP:0003002)1.20494288
99Abnormal urine output (HP:0012590)1.19764279
100Bundle branch block (HP:0011710)1.19262650

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK39.43507505
2PDK49.43507505
3PDK26.13912634
4TESK14.32938831
5PRKD33.35722510
6ICK3.06880714
7PTK2B2.24408312
8WNK42.22206501
9STK392.17003857
10PNCK1.77868858
11NEK21.48609306
12STK381.39836192
13PDK11.10148867
14DYRK1B1.01913038
15LMTK20.83742462
16WNK10.82495382
17TYRO30.81836663
18IRAK10.81704805
19CCNB10.78771388
20MAPK150.73333054
21DYRK30.72597581
22STK30.70289042
23PASK0.69944540
24CHEK20.61261572
25PLK40.58557968
26WEE10.58321682
27TTK0.57403969
28STK38L0.54781902
29PDPK10.51580941
30PINK10.50255218
31MAP2K60.48447126
32CDC70.44852587
33CHEK10.44576585
34BRSK20.42017017
35TESK20.39998874
36RIPK40.38214512
37ATR0.37820733
38CAMK1G0.36886873
39EEF2K0.35439588
40IRAK20.34089682
41MUSK0.29856775
42ATM0.29134561
43MAP2K70.28775715
44PAK10.27540384
45PRKCG0.25708635
46NTRK20.24021281
47CDK120.23755621
48PLK10.20500650
49MAP3K40.20199132
50MAPKAPK50.19149677
51NEK60.19081323
52CAMKK10.18752064
53MTOR0.16952217
54PAK20.16411776
55PRKAA10.15322771
56BRSK10.14417960
57RPS6KB10.14182219
58ZAP700.13942929
59MARK30.12751726
60MARK20.10980128
61PRKG20.10827816
62PRKCQ0.10823748
63YES10.10430311
64MAP3K100.10147546
65PRKCZ0.09572088
66RIPK10.08627363
67PDGFRB0.08183040
68CDK150.08056584
69BMPR1B0.07740036
70WNK30.07594411
71PKN10.07259867
72CSNK2A10.07121993
73PRKG10.06936924
74CDK180.05666411
75PRKACG0.05503458
76STK110.05340833
77CDK11A0.05115986
78CSNK2A20.04707023
79STK100.04571655
80GSK3B0.04428282
81CDK10.04221730
82BRAF0.04095086
83CSNK1D0.04023909
84CDK20.03121029
85MAPK80.02621908
86EGFR0.02341532
87MAP3K50.01737628
88CDK140.01679757
89CAMK2A0.01652719
90RPS6KA10.01375030
91PRKDC0.00929744
92CSF1R0.00543351
93PRKACB0.00478701
94PRKCB0.00246900
95RPS6KA3-0.0290772
96PRKACA-0.0283377
97CDK3-0.0204807
98MAPK10-0.0164432
99PRKCD-0.0074802
100PRKCA-0.0031990

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.45005396
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.38975937
3Pyruvate metabolism_Homo sapiens_hsa006203.99123167
4Fatty acid biosynthesis_Homo sapiens_hsa000613.60828506
5Propanoate metabolism_Homo sapiens_hsa006403.23756008
6Basal transcription factors_Homo sapiens_hsa030222.78563249
7Glucagon signaling pathway_Homo sapiens_hsa049222.73927723
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.66944692
9Pentose phosphate pathway_Homo sapiens_hsa000302.66605344
10Linoleic acid metabolism_Homo sapiens_hsa005912.59939651
11Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.34525715
12Glycosaminoglycan degradation_Homo sapiens_hsa005312.22330810
13Selenocompound metabolism_Homo sapiens_hsa004502.19058191
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.10409559
15Glycerolipid metabolism_Homo sapiens_hsa005611.99316967
16Fanconi anemia pathway_Homo sapiens_hsa034601.98358490
17Oocyte meiosis_Homo sapiens_hsa041141.92102919
18Carbohydrate digestion and absorption_Homo sapiens_hsa049731.83305829
19Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.80769401
20PPAR signaling pathway_Homo sapiens_hsa033201.66819563
21Dorso-ventral axis formation_Homo sapiens_hsa043201.63236373
22Carbon metabolism_Homo sapiens_hsa012001.53514564
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.49326564
24Huntingtons disease_Homo sapiens_hsa050161.48287810
25Glycerophospholipid metabolism_Homo sapiens_hsa005641.44839355
26Amphetamine addiction_Homo sapiens_hsa050311.41523233
27Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.34861019
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.33796435
29Mineral absorption_Homo sapiens_hsa049781.31905920
30Fructose and mannose metabolism_Homo sapiens_hsa000511.31815671
31Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.23028283
32Cardiac muscle contraction_Homo sapiens_hsa042601.21777728
33Fat digestion and absorption_Homo sapiens_hsa049751.21621804
34Ether lipid metabolism_Homo sapiens_hsa005651.21195230
35Renin secretion_Homo sapiens_hsa049241.17714972
36Biosynthesis of amino acids_Homo sapiens_hsa012301.13667784
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.11905987
38Antigen processing and presentation_Homo sapiens_hsa046121.07577819
39mRNA surveillance pathway_Homo sapiens_hsa030151.07038804
40Fatty acid degradation_Homo sapiens_hsa000711.04266092
41Purine metabolism_Homo sapiens_hsa002301.03587164
42Fatty acid metabolism_Homo sapiens_hsa012121.01745057
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95052923
44Renin-angiotensin system_Homo sapiens_hsa046140.94872794
45RNA transport_Homo sapiens_hsa030130.93827865
46Collecting duct acid secretion_Homo sapiens_hsa049660.89599780
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.88398946
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.85926851
49Glutathione metabolism_Homo sapiens_hsa004800.83195468
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78528478
51Chemical carcinogenesis_Homo sapiens_hsa052040.75535021
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71280049
53ABC transporters_Homo sapiens_hsa020100.68516086
54Long-term potentiation_Homo sapiens_hsa047200.67339946
55Insulin secretion_Homo sapiens_hsa049110.62701059
56Inositol phosphate metabolism_Homo sapiens_hsa005620.62634243
57Estrogen signaling pathway_Homo sapiens_hsa049150.61215860
58Bile secretion_Homo sapiens_hsa049760.59182715
59Calcium signaling pathway_Homo sapiens_hsa040200.58881115
60Arachidonic acid metabolism_Homo sapiens_hsa005900.58602595
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58218721
62Thyroid hormone synthesis_Homo sapiens_hsa049180.57241140
63Systemic lupus erythematosus_Homo sapiens_hsa053220.57061896
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56457167
65Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54168687
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.53601207
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.51702866
68Hedgehog signaling pathway_Homo sapiens_hsa043400.49315128
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47409629
70Synaptic vesicle cycle_Homo sapiens_hsa047210.45101666
71Protein digestion and absorption_Homo sapiens_hsa049740.42922219
72Legionellosis_Homo sapiens_hsa051340.42734542
73Metabolic pathways_Homo sapiens_hsa011000.42546448
74Pancreatic secretion_Homo sapiens_hsa049720.42099346
75N-Glycan biosynthesis_Homo sapiens_hsa005100.39331434
76Endocytosis_Homo sapiens_hsa041440.38962429
77Taste transduction_Homo sapiens_hsa047420.38732787
78AMPK signaling pathway_Homo sapiens_hsa041520.36895225
79Salivary secretion_Homo sapiens_hsa049700.34934104
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30602826
81Sulfur metabolism_Homo sapiens_hsa009200.30266463
82Gastric acid secretion_Homo sapiens_hsa049710.28250751
83VEGF signaling pathway_Homo sapiens_hsa043700.27311290
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.26306479
85Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.24833490
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.24429953
87Homologous recombination_Homo sapiens_hsa034400.24423298
88cAMP signaling pathway_Homo sapiens_hsa040240.22565984
89Circadian entrainment_Homo sapiens_hsa047130.21340880
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.20920802
91Pyrimidine metabolism_Homo sapiens_hsa002400.17627604
92Retinol metabolism_Homo sapiens_hsa008300.14718626
93Cell cycle_Homo sapiens_hsa041100.13832117
94Salmonella infection_Homo sapiens_hsa051320.12661803
95RNA degradation_Homo sapiens_hsa030180.11443441
96Alcoholism_Homo sapiens_hsa050340.11123682
97Wnt signaling pathway_Homo sapiens_hsa043100.11016259
98Viral carcinogenesis_Homo sapiens_hsa052030.10530215
99B cell receptor signaling pathway_Homo sapiens_hsa046620.10001803
100Cocaine addiction_Homo sapiens_hsa050300.05702862

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