MS4A15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vitamin transmembrane transport (GO:0035461)9.83087801
2dichotomous subdivision of an epithelial terminal unit (GO:0060600)7.61087527
3folic acid transport (GO:0015884)7.04093693
4nucleoside transmembrane transport (GO:1901642)6.74098359
5peptide catabolic process (GO:0043171)6.26220115
6ribosomal small subunit biogenesis (GO:0042274)5.45553959
7glucosamine-containing compound catabolic process (GO:1901072)5.40582657
8ribosomal small subunit assembly (GO:0000028)5.09868810
9DNA damage induced protein phosphorylation (GO:0006975)5.01467661
10interleukin-6-mediated signaling pathway (GO:0070102)4.76238958
11nucleoside transport (GO:0015858)4.75748540
12peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.68872205
13regulation of oxidative phosphorylation (GO:0002082)4.62796625
14establishment of apical/basal cell polarity (GO:0035089)4.56345341
15regulation of cellular respiration (GO:0043457)4.51421109
16viral transcription (GO:0019083)4.47363608
17definitive hemopoiesis (GO:0060216)4.41051809
18postsynaptic membrane organization (GO:0001941)4.37072859
19regulation of chemokine-mediated signaling pathway (GO:0070099)4.35327280
20interkinetic nuclear migration (GO:0022027)4.30832227
21limb bud formation (GO:0060174)4.28387944
22type B pancreatic cell proliferation (GO:0044342)4.27402717
23translational termination (GO:0006415)4.21849344
24negative regulation of complement activation (GO:0045916)4.14786844
25glomerular basement membrane development (GO:0032836)4.05024574
26mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.04364730
27regulation of phospholipid biosynthetic process (GO:0071071)3.99552365
28maturation of SSU-rRNA (GO:0030490)3.98489489
29iron ion import (GO:0097286)3.97371093
30polarized epithelial cell differentiation (GO:0030859)3.89446737
31cellular response to nitric oxide (GO:0071732)3.84277600
32cotranslational protein targeting to membrane (GO:0006613)3.80671392
33SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.80049767
34deoxyribose phosphate biosynthetic process (GO:0046385)3.77758728
352-deoxyribonucleotide biosynthetic process (GO:0009265)3.77758728
36I-kappaB phosphorylation (GO:0007252)3.75855637
37superoxide anion generation (GO:0042554)3.75415976
38protein targeting to ER (GO:0045047)3.74468316
39positive regulation of respiratory burst (GO:0060267)3.70894848
40azole transport (GO:0045117)3.68343493
41energy homeostasis (GO:0097009)3.64723801
42regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.64668299
43establishment or maintenance of monopolar cell polarity (GO:0061339)3.62824204
44establishment of monopolar cell polarity (GO:0061162)3.62824204
45negative regulation of protein activation cascade (GO:2000258)3.59176845
46negative regulation of humoral immune response (GO:0002921)3.58378298
47establishment of protein localization to endoplasmic reticulum (GO:0072599)3.52523687
48histamine secretion (GO:0001821)3.51524035
49neuron fate determination (GO:0048664)3.49070625
50regulation of cardioblast differentiation (GO:0051890)3.48671981
51protein localization to endoplasmic reticulum (GO:0070972)3.48513622
52positive regulation of uterine smooth muscle contraction (GO:0070474)3.48007047
53negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.47596949
54negative regulation of cAMP-mediated signaling (GO:0043951)3.46775866
55negative regulation of axon guidance (GO:1902668)3.44527415
56lung secretory cell differentiation (GO:0061140)3.40925966
57protein localization to microtubule (GO:0035372)3.40317368
58mitochondrial genome maintenance (GO:0000002)3.39797534
59positive regulation of protein kinase C signaling (GO:0090037)3.37465599
60axon ensheathment in central nervous system (GO:0032291)3.35560243
61central nervous system myelination (GO:0022010)3.35560243
62cellular protein complex disassembly (GO:0043624)3.33487153
63negative regulation of axon extension involved in axon guidance (GO:0048843)3.30668058
64branching involved in salivary gland morphogenesis (GO:0060445)3.27586168
65enteric nervous system development (GO:0048484)3.27383316
66lung lobe morphogenesis (GO:0060463)3.25680157
67nucleotide transmembrane transport (GO:1901679)3.24019703
68pinocytosis (GO:0006907)3.23377026
69motile cilium assembly (GO:0044458)3.23167478
70phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.21799533
71viral life cycle (GO:0019058)3.20880659
72outer ear morphogenesis (GO:0042473)3.19809596
73sulfate transmembrane transport (GO:1902358)3.19077157
74amino sugar catabolic process (GO:0046348)3.18816688
75positive regulation of catecholamine secretion (GO:0033605)3.18172719
76retina vasculature morphogenesis in camera-type eye (GO:0061299)3.17972099
77otic vesicle formation (GO:0030916)3.16011043
78calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.14172011
79synapsis (GO:0007129)3.13313107
80cellular response to ATP (GO:0071318)3.12778964
81phosphate ion homeostasis (GO:0055062)3.12716305
82trivalent inorganic anion homeostasis (GO:0072506)3.12716305
83cellular response to reactive nitrogen species (GO:1902170)3.11873382
84cell volume homeostasis (GO:0006884)3.11571158
85planar cell polarity pathway involved in neural tube closure (GO:0090179)3.10619728
86oocyte maturation (GO:0001556)3.10334380
87polyol transport (GO:0015791)3.06989046
88regulation of hippo signaling (GO:0035330)3.06954233
89negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.06507960
90opioid receptor signaling pathway (GO:0038003)3.05303314
91translational elongation (GO:0006414)3.03906761
92sulfur compound transport (GO:0072348)3.03151580
93keratinocyte development (GO:0003334)3.03089055
94response to interleukin-6 (GO:0070741)3.01679186
95sympathetic nervous system development (GO:0048485)2.95060002
96negative regulation of cell cycle G2/M phase transition (GO:1902750)2.94555059
97respiratory gaseous exchange (GO:0007585)2.93319902
98cofactor transport (GO:0051181)2.92994584
99transepithelial transport (GO:0070633)2.91547297
100virion attachment to host cell (GO:0019062)2.90365942
101adhesion of symbiont to host cell (GO:0044650)2.90365942
102positive regulation of defense response to virus by host (GO:0002230)2.87062344
103organic cation transport (GO:0015695)2.86920671
104somite rostral/caudal axis specification (GO:0032525)2.86474612
105positive regulation of T cell migration (GO:2000406)2.85704272
106regulation of integrin-mediated signaling pathway (GO:2001044)2.85012040
107protein heterotetramerization (GO:0051290)2.84928690
108negative regulation of myoblast differentiation (GO:0045662)2.84528680
109cellular response to thyroid hormone stimulus (GO:0097067)2.84439260
110regulation of transforming growth factor beta1 production (GO:0032908)2.83725470
111positive regulation of action potential (GO:0045760)2.82627306
112mesenchymal to epithelial transition (GO:0060231)2.81482614
113negative regulation of cytosolic calcium ion concentration (GO:0051481)2.80867364
114import into cell (GO:0098657)2.80857307
115DNA replication checkpoint (GO:0000076)2.80481480
116peristalsis (GO:0030432)2.77002096
117axonemal dynein complex assembly (GO:0070286)2.76691068
118one-carbon compound transport (GO:0019755)2.76318486
119establishment of tissue polarity (GO:0007164)2.75206198
120establishment of planar polarity (GO:0001736)2.75206198
121nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.75121105
122face development (GO:0060324)2.74479904
123regulation of somitogenesis (GO:0014807)2.73749004
124modified amino acid transport (GO:0072337)2.73185564
125regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.73129705
126kinetochore assembly (GO:0051382)2.73054305
127regulation of protein kinase C signaling (GO:0090036)2.72692624
128pathway-restricted SMAD protein phosphorylation (GO:0060389)2.72155993
129biotin metabolic process (GO:0006768)2.71541992
130multicellular organism reproduction (GO:0032504)2.70424574
131ribosomal large subunit biogenesis (GO:0042273)2.67928916
132lung epithelium development (GO:0060428)2.67712039
133kinetochore organization (GO:0051383)2.66140458
134labyrinthine layer development (GO:0060711)2.65206448
135phosphatidylcholine acyl-chain remodeling (GO:0036151)2.64674285
136sulfate transport (GO:0008272)2.64164401
137protein complex disassembly (GO:0043241)2.63751779
138regulation of uterine smooth muscle contraction (GO:0070472)2.63201840
139protein kinase C signaling (GO:0070528)2.63028436
140positive regulation of lymphocyte migration (GO:2000403)2.62189254
141hematopoietic stem cell proliferation (GO:0071425)2.61570110
142positive regulation of interleukin-1 beta secretion (GO:0050718)2.59468650
143cellular response to interferon-beta (GO:0035458)2.58027413
144lateral sprouting from an epithelium (GO:0060601)2.53511328
145response to nitric oxide (GO:0071731)2.53248275
146hemidesmosome assembly (GO:0031581)2.52126196
147ATP synthesis coupled proton transport (GO:0015986)2.52109256
148energy coupled proton transport, down electrochemical gradient (GO:0015985)2.52109256
149negative regulation of chemotaxis (GO:0050922)2.51964905
150regulation of glucocorticoid secretion (GO:2000849)2.51258436
151macromolecular complex disassembly (GO:0032984)2.49248013
152cardiac muscle hypertrophy in response to stress (GO:0014898)2.48556057
153muscle hypertrophy in response to stress (GO:0003299)2.48556057
154cardiac muscle adaptation (GO:0014887)2.48556057
155lymph vessel development (GO:0001945)2.47936749
156retinal ganglion cell axon guidance (GO:0031290)2.47485056
157viral protein processing (GO:0019082)2.46060244
158regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.44142659
159eye photoreceptor cell differentiation (GO:0001754)2.43947535
160photoreceptor cell differentiation (GO:0046530)2.43947535
161positive regulation of cell fate commitment (GO:0010455)2.43158397
162deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.42648101
163regulation of dendritic cell antigen processing and presentation (GO:0002604)2.41908291
164DNA strand renaturation (GO:0000733)2.39728083
165G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.36448069
166positive regulation of interleukin-1 secretion (GO:0050716)2.35955597
167platelet dense granule organization (GO:0060155)2.35285120
168regulation of mesonephros development (GO:0061217)2.35066818
169regulation of mesenchymal cell apoptotic process (GO:2001053)2.34749416
170regulation of T cell migration (GO:2000404)2.34735637
171response to X-ray (GO:0010165)2.34596979
172mesenchymal cell differentiation involved in kidney development (GO:0072161)2.34305243
173mesenchymal cell differentiation involved in renal system development (GO:2001012)2.34305243
174histamine transport (GO:0051608)2.33966646
175attachment of spindle microtubules to kinetochore (GO:0008608)2.33923409
176inner ear receptor stereocilium organization (GO:0060122)2.33845720
177positive regulation of monocyte chemotaxis (GO:0090026)2.33780064
178phasic smooth muscle contraction (GO:0014821)2.33579771
179G-protein coupled receptor internalization (GO:0002031)2.31361263
180positive regulation of embryonic development (GO:0040019)2.31205317
181mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.31027994
182superoxide metabolic process (GO:0006801)2.30480432
183detection of other organism (GO:0098543)2.30301366
184regulation of dopamine secretion (GO:0014059)2.29865021
185centriole assembly (GO:0098534)2.29217770
186positive regulation of meiotic cell cycle (GO:0051446)2.29061931
187regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.29060399
188regulation of respiratory burst (GO:0060263)2.28751667
189inner ear morphogenesis (GO:0042472)2.27061230
190response to peptidoglycan (GO:0032494)2.26459342
191pyrimidine-containing compound transmembrane transport (GO:0072531)16.0395164
192surfactant homeostasis (GO:0043129)15.2168005
193chemical homeostasis within a tissue (GO:0048875)12.7490734

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_21235772_ChIP-Seq_MCF-7_Human3.86547112
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.83724002
3GBX2_23144817_ChIP-Seq_PC3_Human3.50278734
4AHR_22903824_ChIP-Seq_MCF-7_Human3.40137469
5EZH2_22144423_ChIP-Seq_EOC_Human2.71492104
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.70689814
7STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.69769490
8BMI1_23680149_ChIP-Seq_NPCS_Mouse2.69185046
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.67298239
10ZNF274_21170338_ChIP-Seq_K562_Hela2.66057054
11ESR2_21235772_ChIP-Seq_MCF-7_Human2.49238373
12FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.47393813
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.37335492
14GATA1_22025678_ChIP-Seq_K562_Human2.36713199
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.29812313
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.28230286
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.25922600
18IGF1R_20145208_ChIP-Seq_DFB_Human2.25634525
19TP63_17297297_ChIP-ChIP_HaCaT_Human2.24642323
20ARNT_22903824_ChIP-Seq_MCF-7_Human2.22586292
21TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.22554887
22CBX2_27304074_Chip-Seq_ESCs_Mouse2.19184132
23TAF15_26573619_Chip-Seq_HEK293_Human2.18319925
24JARID2_20064375_ChIP-Seq_MESCs_Mouse2.17062727
25RNF2_27304074_Chip-Seq_NSC_Mouse2.09433917
26EZH2_27304074_Chip-Seq_ESCs_Mouse2.08086064
27ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.06290822
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.05092072
29ESR1_20079471_ChIP-ChIP_T-47D_Human2.03502587
30LXR_22158963_ChIP-Seq_LIVER_Mouse2.03130441
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.01883218
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.95075836
33SUZ12_27294783_Chip-Seq_NPCs_Mouse1.94702165
34SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.93699055
35NFE2_27457419_Chip-Seq_LIVER_Mouse1.93145415
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.93139663
37ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.93100675
38SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.91964996
39PCGF2_27294783_Chip-Seq_NPCs_Mouse1.91310340
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88875115
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.87374286
42FUS_26573619_Chip-Seq_HEK293_Human1.87185492
43VDR_22108803_ChIP-Seq_LS180_Human1.86878225
44SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.85740650
45SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.81814084
46EWS_26573619_Chip-Seq_HEK293_Human1.81474399
47E2F1_18555785_Chip-Seq_ESCs_Mouse1.78453429
48NANOG_18555785_Chip-Seq_ESCs_Mouse1.76701013
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.76254242
50EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.76165622
51RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75841330
52GATA2_21666600_ChIP-Seq_HMVEC_Human1.75568590
53SUZ12_18555785_Chip-Seq_ESCs_Mouse1.75436108
54GATA4_25053715_ChIP-Seq_YYC3_Human1.73966216
55IRF8_22096565_ChIP-ChIP_GC-B_Human1.72706140
56P53_22387025_ChIP-Seq_ESCs_Mouse1.72485363
57EZH2_27294783_Chip-Seq_ESCs_Mouse1.72195166
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70323751
59NMYC_18555785_Chip-Seq_ESCs_Mouse1.68578798
60FOXM1_26456572_ChIP-Seq_MCF-7_Human1.67436518
61SUZ12_27294783_Chip-Seq_ESCs_Mouse1.66928597
62P300_18555785_Chip-Seq_ESCs_Mouse1.66872089
63PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.66605696
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.66576287
65JARID2_20075857_ChIP-Seq_MESCs_Mouse1.66408628
66EP300_21415370_ChIP-Seq_HL-1_Mouse1.64149171
67EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.62249673
68CMYC_18555785_Chip-Seq_ESCs_Mouse1.61331900
69RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.60327634
70STAT3_18555785_Chip-Seq_ESCs_Mouse1.59913434
71RNF2_27304074_Chip-Seq_ESCs_Mouse1.59370718
72P300_19829295_ChIP-Seq_ESCs_Human1.58953844
73SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.56606401
74ER_23166858_ChIP-Seq_MCF-7_Human1.55961318
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.55761640
76OCT4_18555785_Chip-Seq_ESCs_Mouse1.55756994
77SOX2_18555785_Chip-Seq_ESCs_Mouse1.54404378
78EZH2_18974828_ChIP-Seq_MESCs_Mouse1.53692748
79RNF2_18974828_ChIP-Seq_MESCs_Mouse1.53692748
80KLF4_18555785_Chip-Seq_ESCs_Mouse1.50016325
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.46754765
82CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46517960
83ZFX_18555785_Chip-Seq_ESCs_Mouse1.45605993
84GATA3_21878914_ChIP-Seq_MCF-7_Human1.44397025
85ESRRB_18555785_Chip-Seq_ESCs_Mouse1.41946158
86PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40988362
87ZNF217_24962896_ChIP-Seq_MCF-7_Human1.40365384
88SMAD1_18555785_Chip-Seq_ESCs_Mouse1.39600944
89P53_22127205_ChIP-Seq_FIBROBLAST_Human1.39124237
90POU3F2_20337985_ChIP-ChIP_501MEL_Human1.39107519
91RUNX1_27457419_Chip-Seq_LIVER_Mouse1.37911141
92RUNX_20019798_ChIP-Seq_JUKART_Human1.37466424
93P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.37086980
94VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.36430232
95GATA1_19941826_ChIP-Seq_K562_Human1.35989908
96HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.35307813
97KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.35003895
98KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.35003895
99KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.35003895
100PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.34265612
101CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33020937
102SMAD3_21741376_ChIP-Seq_HESCs_Human1.32958773
103POU5F1_16153702_ChIP-ChIP_HESCs_Human1.32504599
104CJUN_26792858_Chip-Seq_BT549_Human1.32503205
105STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.32080860
106TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.29914482
107PU1_27457419_Chip-Seq_LIVER_Mouse1.29474508
108PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.28957614
109SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.27033479
110ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.26992448
111TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26851597
112POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26851597
113TAL1_26923725_Chip-Seq_HPCs_Mouse1.26649998
114EGR1_23403033_ChIP-Seq_LIVER_Mouse1.26585003
115CTCF_20526341_ChIP-Seq_ESCs_Human1.26495407
116MTF2_20144788_ChIP-Seq_MESCs_Mouse1.25809589
117GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.24629746
118LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.24152004
119* RUNX2_22187159_ChIP-Seq_PCA_Human1.23273423
120SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22910906
121CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22557164
122CTCF_18555785_Chip-Seq_ESCs_Mouse1.22445734
123CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.19955129
124TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19745617
125IKZF1_21737484_ChIP-ChIP_HCT116_Human1.18838525
126VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17816887
127AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17470315
128MYC_19829295_ChIP-Seq_ESCs_Human1.16951968
129TP53_18474530_ChIP-ChIP_U2OS_Human1.16282475
130IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.16230906
131UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10668746
132ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.10425654
133NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10294329
134MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08936284
135BP1_19119308_ChIP-ChIP_Hs578T_Human1.08043217
136TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07668190
137GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07299031
138WT1_19549856_ChIP-ChIP_CCG9911_Human1.07267166
139CDX2_22108803_ChIP-Seq_LS180_Human1.07216873
140IRF1_19129219_ChIP-ChIP_H3396_Human1.07034692
141SCL_19346495_ChIP-Seq_HPC-7_Human1.07001986
142SMAD3_21741376_ChIP-Seq_EPCs_Human1.06905112
143SALL1_21062744_ChIP-ChIP_HESCs_Human1.06873565
144CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06758132
145TP53_16413492_ChIP-PET_HCT116_Human1.06479131
146TRIM28_21343339_ChIP-Seq_HEK293_Human1.06446587
147* ERA_21632823_ChIP-Seq_H3396_Human1.05865700
148TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.04274547
149TBX20_22328084_ChIP-Seq_HEART_Mouse1.03723601
150TBX20_22080862_ChIP-Seq_HEART_Mouse1.03723601
151SMRT_27268052_Chip-Seq_Bcells_Human1.03202398
152AR_21572438_ChIP-Seq_LNCaP_Human1.03123347
153CRX_20693478_ChIP-Seq_RETINA_Mouse1.02754172
154PPARA_22158963_ChIP-Seq_LIVER_Mouse1.02752154
155* TP63_22573176_ChIP-Seq_HFKS_Human1.02629500
156SMAD4_21799915_ChIP-Seq_A2780_Human1.02462577
157CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.01514807
158OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01085388
159RUNX1_27514584_Chip-Seq_MCF-7_Human1.00915736
160STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.00560384
161BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99868913
162KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.99841519
163DROSHA_22980978_ChIP-Seq_HELA_Human0.98460425
164BCAT_22108803_ChIP-Seq_LS180_Human0.97866897
165Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.97269124
166* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.96501978
167TDRD3_21172665_ChIP-Seq_MCF-7_Human0.96420271
168OCT4_20526341_ChIP-Seq_ESCs_Human0.96398813
169TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95736569
170RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.94882967
171PPAR_26484153_Chip-Seq_NCI-H1993_Human0.92584759
172FOXA1_27270436_Chip-Seq_PROSTATE_Human0.92225387
173FOXA1_25329375_ChIP-Seq_VCAP_Human0.92225387
174STAT1_20625510_ChIP-Seq_HELA_Human0.91781376
175SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91448847
176* BCOR_27268052_Chip-Seq_Bcells_Human0.90519102
177ETV2_25802403_ChIP-Seq_MESCs_Mouse0.90231496
178SMAD4_21741376_ChIP-Seq_EPCs_Human0.89182409
179PRDM14_20953172_ChIP-Seq_ESCs_Human0.88564946
180AR_25329375_ChIP-Seq_VCAP_Human0.88546530
181RXR_22158963_ChIP-Seq_LIVER_Mouse0.87145287
182TCF4_22108803_ChIP-Seq_LS180_Human0.86884536
183CTCF_27219007_Chip-Seq_Bcells_Human0.86721705
184RAC3_21632823_ChIP-Seq_H3396_Human0.85960238
185AUTS2_25519132_ChIP-Seq_293T-REX_Human0.85278219
186SMC4_20622854_ChIP-Seq_HELA_Human0.85080712

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004782_abnormal_surfactant_physiolog6.74649628
2MP0003806_abnormal_nucleotide_metabolis5.40410833
3MP0009379_abnormal_foot_pigmentation5.04421115
4MP0001958_emphysema4.69105914
5MP0000566_synostosis4.18073810
6MP0001346_abnormal_lacrimal_gland3.94014040
7MP0004381_abnormal_hair_follicle3.56821030
8MP0005360_urolithiasis2.93940917
9MP0005248_abnormal_Harderian_gland2.78454650
10MP0005645_abnormal_hypothalamus_physiol2.76989610
11MP0002277_abnormal_respiratory_mucosa2.71286753
12MP0004084_abnormal_cardiac_muscle2.67631914
13MP0000383_abnormal_hair_follicle2.62482551
14MP0003950_abnormal_plasma_membrane2.60532533
15MP0005171_absent_coat_pigmentation2.60257203
16MP0003566_abnormal_cell_adhesion2.59584345
17MP0003136_yellow_coat_color2.59111389
18MP0002009_preneoplasia2.57732503
19MP0003941_abnormal_skin_development2.44878806
20MP0001853_heart_inflammation2.38671979
21MP0006292_abnormal_olfactory_placode2.34879046
22MP0002132_abnormal_respiratory_system2.25745792
23MP0005377_hearing/vestibular/ear_phenot2.15559965
24MP0003878_abnormal_ear_physiology2.15559965
25MP0002133_abnormal_respiratory_system2.10925546
26MP0005388_respiratory_system_phenotype2.10925546
27MP0008775_abnormal_heart_ventricle2.03946596
28MP0010030_abnormal_orbit_morphology2.03104850
29MP0002163_abnormal_gland_morphology1.97282628
30MP0005083_abnormal_biliary_tract1.96448778
31MP0005174_abnormal_tail_pigmentation1.94694590
32MP0005409_darkened_coat_color1.89061044
33MP0001177_atelectasis1.84733669
34MP0001485_abnormal_pinna_reflex1.81741647
35MP0002098_abnormal_vibrissa_morphology1.72301655
36MP0002933_joint_inflammation1.70462591
37MP0001188_hyperpigmentation1.69074464
38MP0008057_abnormal_DNA_replication1.66011720
39MP0004742_abnormal_vestibular_system1.64537826
40MP0005595_abnormal_vascular_smooth1.63579057
41MP0002160_abnormal_reproductive_system1.62984950
42MP0002751_abnormal_autonomic_nervous1.60848237
43MP0005164_abnormal_response_to1.60578299
44MP0005499_abnormal_olfactory_system1.59011636
45MP0005394_taste/olfaction_phenotype1.59011636
46MP0002295_abnormal_pulmonary_circulatio1.58673050
47MP0005379_endocrine/exocrine_gland_phen1.55938891
48MP0004036_abnormal_muscle_relaxation1.52503557
49MP0010368_abnormal_lymphatic_system1.52317792
50MP0010678_abnormal_skin_adnexa1.50935200
51MP0002148_abnormal_hypersensitivity_rea1.50201732
52MP0008789_abnormal_olfactory_epithelium1.47698637
53MP0009697_abnormal_copulation1.47186008
54MP0006138_congestive_heart_failure1.44400907
55MP0005410_abnormal_fertilization1.44072952
56MP0000049_abnormal_middle_ear1.43154243
57MP0000778_abnormal_nervous_system1.42572516
58MP0000762_abnormal_tongue_morphology1.42472845
59MP0000733_abnormal_muscle_development1.40951833
60MP0004484_altered_response_of1.40138997
61MP0001529_abnormal_vocalization1.37706610
62MP0001661_extended_life_span1.36564067
63MP0002638_abnormal_pupillary_reflex1.34187280
64MP0000026_abnormal_inner_ear1.33967742
65MP0003828_pulmonary_edema1.32423750
66MP0008875_abnormal_xenobiotic_pharmacok1.30632458
67MP0010386_abnormal_urinary_bladder1.29518400
68MP0005084_abnormal_gallbladder_morpholo1.29274238
69MP0003787_abnormal_imprinting1.28039123
70MP0005646_abnormal_pituitary_gland1.26371399
71MP0001486_abnormal_startle_reflex1.25959088
72MP0006276_abnormal_autonomic_nervous1.25737503
73MP0004085_abnormal_heartbeat1.25304907
74MP0002233_abnormal_nose_morphology1.25262091
75MP0003880_abnormal_central_pattern1.24498068
76MP0000015_abnormal_ear_pigmentation1.21297115
77MP0005167_abnormal_blood-brain_barrier1.17726977
78MP0000613_abnormal_salivary_gland1.17662324
79MP0002127_abnormal_cardiovascular_syste1.17492892
80MP0000470_abnormal_stomach_morphology1.17363491
81MP0000462_abnormal_digestive_system1.16445340
82MP0001986_abnormal_taste_sensitivity1.15593462
83MP0005408_hypopigmentation1.15102804
84MP0000920_abnormal_myelination1.15022872
85MP0003718_maternal_effect1.14213941
86MP0008995_early_reproductive_senescence1.13351288
87MP0001919_abnormal_reproductive_system1.13295684
88MP0003693_abnormal_embryo_hatching1.12037706
89MP0001984_abnormal_olfaction1.07407262
90MP0003191_abnormal_cellular_cholesterol1.07257149
91MP0000467_abnormal_esophagus_morphology1.05253970
92MP0009840_abnormal_foam_cell1.01205575
93MP0005387_immune_system_phenotype1.00561228
94MP0001790_abnormal_immune_system1.00561228
95MP0001905_abnormal_dopamine_level0.99371023
96MP0002184_abnormal_innervation0.98657047
97MP0005623_abnormal_meninges_morphology0.98199346
98MP0000538_abnormal_urinary_bladder0.97476853
99MP0001502_abnormal_circadian_rhythm0.96773262
100MP0006082_CNS_inflammation0.96537908
101MP0004883_abnormal_blood_vessel0.95976321
102MP0000631_abnormal_neuroendocrine_gland0.95632128
103MP0001270_distended_abdomen0.95488809
104MP0001873_stomach_inflammation0.95033392
105MP0001756_abnormal_urination0.94872959
106MP0002006_tumorigenesis0.93900987
107MP0002060_abnormal_skin_morphology0.93694277
108MP0005058_abnormal_lysosome_morphology0.90919003
109MP0003943_abnormal_hepatobiliary_system0.90642345
110MP0009643_abnormal_urine_homeostasis0.90564839
111MP0004264_abnormal_extraembryonic_tissu0.90269190
112MP0000579_abnormal_nail_morphology0.87185203
113MP0002229_neurodegeneration0.86137076
114MP0000767_abnormal_smooth_muscle0.85703632
115MP0003567_abnormal_fetal_cardiomyocyte0.85373471
116MP0009384_cardiac_valve_regurgitation0.83668309
117MP0002405_respiratory_system_inflammati0.83583022
118MP0003724_increased_susceptibility_to0.83494673
119MP0010352_gastrointestinal_tract_polyps0.83473378
120MP0001963_abnormal_hearing_physiology0.83104573
121MP0002095_abnormal_skin_pigmentation0.82358218
122MP0002938_white_spotting0.81967835
123MP0003938_abnormal_ear_development0.80039972
124MP0002128_abnormal_blood_circulation0.79917406
125MP0009745_abnormal_behavioral_response0.79271243
126MP0002752_abnormal_somatic_nervous0.77770837
127MP0003091_abnormal_cell_migration0.77738412
128MP0002735_abnormal_chemical_nociception0.77498145
129MP0002733_abnormal_thermal_nociception0.76513352
130MP0005023_abnormal_wound_healing0.76399806
131MP0001835_abnormal_antigen_presentation0.75483796
132MP0005165_increased_susceptibility_to0.75450015
133MP0002736_abnormal_nociception_after0.75445685
134MP0004947_skin_inflammation0.74291798
135MP0003937_abnormal_limbs/digits/tail_de0.74245966
136MP0005551_abnormal_eye_electrophysiolog0.73771611
137MP0009764_decreased_sensitivity_to0.73667019
138MP0009046_muscle_twitch0.73123899
139MP0005253_abnormal_eye_physiology0.73098904
140MP0001340_abnormal_eyelid_morphology0.72108326
141MP0001664_abnormal_digestion0.71621512
142MP0000647_abnormal_sebaceous_gland0.71309513
143MP0001544_abnormal_cardiovascular_syste0.70981614
144MP0005385_cardiovascular_system_phenoty0.70981614
145MP0001542_abnormal_bone_strength0.70277869
146MP0002272_abnormal_nervous_system0.69983281
147MP0002998_abnormal_bone_remodeling0.69698969
148MP0002177_abnormal_outer_ear0.69382237
149MP0005389_reproductive_system_phenotype0.69100135
150MP0002876_abnormal_thyroid_physiology0.68173918
151MP0003690_abnormal_glial_cell0.67548592
152MP0001851_eye_inflammation0.66824873
153MP0000372_irregular_coat_pigmentation0.66547715
154MP0002136_abnormal_kidney_physiology0.66461802
155MP0003172_abnormal_lysosome_physiology0.66259801
156MP0001614_abnormal_blood_vessel0.66238576
157MP0000678_abnormal_parathyroid_gland0.65970751
158MP0002102_abnormal_ear_morphology0.65566028
159MP0000230_abnormal_systemic_arterial0.64998257
160MP0004885_abnormal_endolymph0.64298875
161MP0002419_abnormal_innate_immunity0.64284627
162MP0002557_abnormal_social/conspecific_i0.64082551
163MP0002572_abnormal_emotion/affect_behav0.63082725
164MP0005391_vision/eye_phenotype0.63000460
165MP0008004_abnormal_stomach_pH0.62424455
166MP0005000_abnormal_immune_tolerance0.62319256
167MP0001501_abnormal_sleep_pattern0.58771099
168MP0005647_abnormal_sex_gland0.58292212
169MP0001545_abnormal_hematopoietic_system0.58192836
170MP0005397_hematopoietic_system_phenotyp0.58192836
171MP0005584_abnormal_enzyme/coenzyme_acti0.57813431
172MP0000377_abnormal_hair_follicle0.57151672
173MP0005376_homeostasis/metabolism_phenot0.56792383
174MP0000465_gastrointestinal_hemorrhage0.55265558
175MP0001175_abnormal_lung_morphology0.53213678
176MP0000249_abnormal_blood_vessel0.52738417

Predicted human phenotypes

RankGene SetZ-score
1Interstitial pulmonary disease (HP:0006530)7.07819154
2Cone-rod dystrophy (HP:0000548)6.53177698
3Cerebellar dysplasia (HP:0007033)5.12582719
4Retinal atrophy (HP:0001105)5.07567812
5Reticulocytopenia (HP:0001896)4.86737606
6Tachypnea (HP:0002789)4.81931734
7Hypomagnesemia (HP:0002917)4.28339320
8Alopecia of scalp (HP:0002293)4.17604626
9Decreased circulating renin level (HP:0003351)4.08957557
10Hyperactive renin-angiotensin system (HP:0000841)3.88371584
11Follicular hyperkeratosis (HP:0007502)3.86944238
12Prolonged neonatal jaundice (HP:0006579)3.85024897
1311 pairs of ribs (HP:0000878)3.72719924
14Agammaglobulinemia (HP:0004432)3.71839183
15Chronic bronchitis (HP:0004469)3.63292211
16Congenital, generalized hypertrichosis (HP:0004540)3.57264457
17Duplicated collecting system (HP:0000081)3.55898132
18Unilateral renal agenesis (HP:0000122)3.50401546
19Chromosomal breakage induced by crosslinking agents (HP:0003221)3.49003259
20Tetany (HP:0001281)3.45299016
21Abnormality of the renal collecting system (HP:0004742)3.41232982
22Abnormality of magnesium homeostasis (HP:0004921)3.36933048
23Mesangial abnormality (HP:0001966)3.29270024
24Aplasia/Hypoplasia of the sacrum (HP:0008517)3.25869721
25Parakeratosis (HP:0001036)3.21550962
26Patent foramen ovale (HP:0001655)3.19245060
27Chronic diarrhea (HP:0002028)3.14112195
28Renal cortical cysts (HP:0000803)3.14102850
29Stenosis of the external auditory canal (HP:0000402)3.08482840
30Chromsome breakage (HP:0040012)3.02483776
31Abnormal ciliary motility (HP:0012262)2.97952343
32Abnormality of the renal cortex (HP:0011035)2.96407392
33Xerostomia (HP:0000217)2.95929797
34Renal salt wasting (HP:0000127)2.90080383
35Abnormal hemoglobin (HP:0011902)2.89544955
36Abnormal pancreas size (HP:0012094)2.88571335
37Abnormality of the periventricular white matter (HP:0002518)2.88069275
38Mildly elevated creatine phosphokinase (HP:0008180)2.87326871
39Tubulointerstitial fibrosis (HP:0005576)2.85389653
40Bell-shaped thorax (HP:0001591)2.83403082
41Spastic tetraparesis (HP:0001285)2.79040600
42Abnormality of renin-angiotensin system (HP:0000847)2.78783507
43Renal Fanconi syndrome (HP:0001994)2.77139562
44Cupped ear (HP:0000378)2.76041543
45Septo-optic dysplasia (HP:0100842)2.74588918
46Seborrheic dermatitis (HP:0001051)2.73960097
47Type I diabetes mellitus (HP:0100651)2.73770930
48Hyperkalemia (HP:0002153)2.73614139
49Redundant skin (HP:0001582)2.71685184
50Neoplasm of the lung (HP:0100526)2.70650503
51Duplication of thumb phalanx (HP:0009942)2.68780845
52Macrocytic anemia (HP:0001972)2.68394720
53Respiratory distress (HP:0002098)2.66401896
54Corneal erosion (HP:0200020)2.65636855
55Abnormality of the aortic arch (HP:0012303)2.65207829
56Dynein arm defect of respiratory motile cilia (HP:0012255)2.64759981
57Absent/shortened dynein arms (HP:0200106)2.64759981
58Retrobulbar optic neuritis (HP:0100654)2.60747031
59Optic neuritis (HP:0100653)2.60747031
60Abnormality of the preputium (HP:0100587)2.56875297
61Aplasia cutis congenita (HP:0001057)2.56453620
62Absent thumb (HP:0009777)2.56378930
63Malignant hyperthermia (HP:0002047)2.54436977
64Increased hepatocellular lipid droplets (HP:0006565)2.54258500
65Stomach cancer (HP:0012126)2.48602473
66Lip pit (HP:0100267)2.47065348
67Abnormal sex determination (HP:0012244)2.45773458
68Sex reversal (HP:0012245)2.45773458
69Ureteral duplication (HP:0000073)2.44774395
70Anhidrosis (HP:0000970)2.41785504
71Morphological abnormality of the inner ear (HP:0011390)2.39727228
72Protruding tongue (HP:0010808)2.39241717
73Abnormality of the right ventricle (HP:0001707)2.38808541
74Partial duplication of thumb phalanx (HP:0009944)2.37417021
75Abnormality of the septum pellucidum (HP:0007375)2.34754815
76Abnormality of the axillary hair (HP:0100134)2.34709633
77Abnormality of secondary sexual hair (HP:0009888)2.34709633
78Abnormality of cells of the erythroid lineage (HP:0012130)2.34637854
79Abnormality of the ileum (HP:0001549)2.33474620
80Widely patent fontanelles and sutures (HP:0004492)2.32030135
81Autoamputation (HP:0001218)2.29975259
82Difficulty walking (HP:0002355)2.27992287
83Tubular atrophy (HP:0000092)2.27921457
84Absent septum pellucidum (HP:0001331)2.26350611
85Abnormality of dental color (HP:0011073)2.26340443
86Pallor (HP:0000980)2.26021419
87Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.25919004
88Neoplasm of the respiratory system (HP:0100606)2.24772481
89Absent eyelashes (HP:0000561)2.24761713
90Meckel diverticulum (HP:0002245)2.24271456
91Hyperaldosteronism (HP:0000859)2.24104178
92Esophageal atresia (HP:0002032)2.23472846
93Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.23264773
94Abnormality of the fingertips (HP:0001211)2.23134852
95Absent rod-and cone-mediated responses on ERG (HP:0007688)2.22605101
96Asplenia (HP:0001746)2.22412417
97Nephronophthisis (HP:0000090)2.22308714
98Absent eyebrow (HP:0002223)2.22161090
99Abnormal respiratory motile cilium physiology (HP:0012261)2.19169268
100Intestinal atresia (HP:0011100)2.18814526
101Abnormality of the renal medulla (HP:0100957)2.18289785
102Hypoplastic female external genitalia (HP:0012815)2.18141918
103Breech presentation (HP:0001623)2.16780695
104Gastrointestinal atresia (HP:0002589)2.16048709
105Ulnar claw (HP:0001178)2.15653472
106Abnormal respiratory motile cilium morphology (HP:0005938)2.15328614
107Abnormal respiratory epithelium morphology (HP:0012253)2.15328614
108Renal dysplasia (HP:0000110)2.14796262
109Abnormality of renal resorption (HP:0011038)2.14179987
110Exertional dyspnea (HP:0002875)2.13683516
111Partial duplication of the phalanx of hand (HP:0009999)2.12278567
112Chronic hepatic failure (HP:0100626)2.12160706
113Triphalangeal thumb (HP:0001199)2.11499628
114Aplasia/Hypoplasia of the uvula (HP:0010293)2.11377141
115Hoarse voice (HP:0001609)2.11000443
116Hypoplastic labia majora (HP:0000059)2.10205700
117Tubulointerstitial nephritis (HP:0001970)2.09306134
118True hermaphroditism (HP:0010459)2.07875332
119Abnormality of the lacrimal duct (HP:0011481)2.06979235
120Nonprogressive disorder (HP:0003680)2.06029894
121Abnormal biliary tract morphology (HP:0012440)2.05601724
122Nasolacrimal duct obstruction (HP:0000579)2.05350457
123Congenital sensorineural hearing impairment (HP:0008527)2.03256579
124Steppage gait (HP:0003376)2.01970940
125Premature loss of primary teeth (HP:0006323)2.01828263
126Abnormality of the nasolacrimal system (HP:0000614)2.00791579
127Abnormality of cochlea (HP:0000375)2.00710508
128Recurrent corneal erosions (HP:0000495)1.99747125
129Abnormality of the parietal bone (HP:0002696)1.99498349
130Double outlet right ventricle (HP:0001719)1.99343270
131Congenital malformation of the right heart (HP:0011723)1.99343270
132Popliteal pterygium (HP:0009756)1.97367114
133Conical tooth (HP:0000698)1.96800288
134Cortical visual impairment (HP:0100704)1.95670467
135Abnormal number of erythroid precursors (HP:0012131)1.94900440
136Lipid accumulation in hepatocytes (HP:0006561)1.94480502
137Megaloblastic anemia (HP:0001889)1.94113179
138Portal hypertension (HP:0001409)1.93516224
139Progressive sensorineural hearing impairment (HP:0000408)1.93160263
140Pulmonary hypertension (HP:0002092)1.91698621
141Absent radius (HP:0003974)1.90503641
142Systemic lupus erythematosus (HP:0002725)1.90244164
143Chin dimple (HP:0010751)1.90230067
144Cerebral palsy (HP:0100021)1.89810793
145Bronchitis (HP:0012387)1.89735084
146Abnormality of the labia majora (HP:0012881)1.88960784
147Neonatal respiratory distress (HP:0002643)1.88697554
148Aplasia/Hypoplasia of the spleen (HP:0010451)1.87225444
149Turricephaly (HP:0000262)1.87155951
150Constricted visual fields (HP:0001133)1.85593270
151Adrenal hypoplasia (HP:0000835)1.85301781
152Restrictive lung disease (HP:0002091)1.84981583
153Orchitis (HP:0100796)1.83915761
154Hypoplastic pelvis (HP:0008839)1.83072327
155Ridged nail (HP:0001807)1.82799356
156Abnormal pupillary function (HP:0007686)1.81936755
157Abnormality of midbrain morphology (HP:0002418)1.81777601
158Molar tooth sign on MRI (HP:0002419)1.81777601
159Tubulointerstitial abnormality (HP:0001969)1.81097397
160Bicornuate uterus (HP:0000813)1.79586834
161Abnormality of the labia minora (HP:0012880)1.79535773
162Mesomelia (HP:0003027)1.79357282
163Chronic otitis media (HP:0000389)1.78453205
164Thickened helices (HP:0000391)1.78218551
165Abnormality of the hepatic vasculature (HP:0006707)1.77951222
166Morphological abnormality of the middle ear (HP:0008609)1.77008818
167Stroke (HP:0001297)1.76848118
168Bronchomalacia (HP:0002780)1.76807011
169Obstructive lung disease (HP:0006536)1.76474689
170Chronic obstructive pulmonary disease (HP:0006510)1.76474689
171Small intestinal stenosis (HP:0012848)1.75280263
172Duodenal stenosis (HP:0100867)1.75280263
173Dry hair (HP:0011359)1.73963664
174Hypoproteinemia (HP:0003075)1.73174044
175Hypokalemic alkalosis (HP:0001949)1.72744267
176Aplasia involving forearm bones (HP:0009822)1.72494740
177Absent forearm bone (HP:0003953)1.72494740
178Decreased central vision (HP:0007663)1.71973618
179Alveolar cell carcinoma (HP:0006519)1.71795472
180Clubbing of toes (HP:0100760)1.71642215
181Cheilitis (HP:0100825)1.71622881
182Breast hypoplasia (HP:0003187)1.71486645
183Labial hypoplasia (HP:0000066)1.71358661
184Renal agenesis (HP:0000104)1.70543198
185Abnormality of the phalanges of the 2nd finger (HP:0009541)1.70166485
186Pulmonary artery stenosis (HP:0004415)1.66889390

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK33.91079036
2TNIK3.14141182
3MAP3K72.70027641
4MST42.57166061
5IRAK42.52252913
6IRAK32.48707532
7NUAK12.35802365
8LMTK22.33044309
9BMPR1B2.31012953
10BMPR22.29904171
11MAPK152.29141918
12MST1R2.22812020
13IRAK22.20948380
14STK162.16435129
15MAP3K142.08553383
16EPHB22.02901656
17MAP3K1311.8080813
18OXSR11.98704048
19CASK1.97030459
20STK391.95275026
21EPHA21.94089014
22FGFR21.89519314
23ADRBK21.89259101
24BRSK21.87510398
25ZAK1.81165585
26BCR1.73784915
27BRD41.72123635
28CLK11.71082193
29SIK31.64624073
30TXK1.58794305
31PRPF4B1.53343756
32SRPK11.51511080
33PINK11.50841677
34CHUK1.40219831
35PKN21.40009832
36PLK41.36389480
37IRAK11.32717889
38UHMK11.31385523
39WNK31.30883806
40EIF2AK21.29843169
41MAPK131.21155463
42ZAP701.21080653
43ARAF1.20230730
44TIE11.16780806
45TLK11.16342771
46CDK191.12166848
47CAMKK21.11545719
48GRK71.11491549
49PKN11.11370412
50BRSK11.06243601
51YES11.04661824
52ERBB31.03465634
53NTRK21.03283338
54NEK60.98594343
55MYLK0.96031467
56CAMKK10.95237951
57FRK0.94080043
58NME20.91806416
59GRK10.88387356
60LATS10.86389785
61PBK0.85194440
62KIT0.75944845
63IKBKE0.75316579
64ABL20.74911082
65MARK10.74567567
66MAP2K70.74036211
67MKNK10.73186460
68IKBKB0.72469803
69CAMK2B0.71197298
70FGFR40.70601237
71LRRK20.69634173
72NEK20.68927911
73INSRR0.68205179
74STK30.67983800
75EGFR0.67321538
76BUB10.67122769
77CDC42BPA0.67065798
78PIM20.65662651
79PRKAA20.65128123
80CAMK1D0.64674266
81CSK0.63596971
82DYRK20.63074030
83EPHA40.62774386
84PDPK10.61184573
85RPS6KA20.60582655
86PRKG20.60222637
87MAPKAPK30.59609404
88CSNK1A1L0.57966468
89PASK0.57648112
90MARK20.56963263
91CSNK1G30.56719798
92STK100.56198554
93MAP3K10.56158863
94PRKCE0.55488424
95WNK10.53678672
96FLT30.53640793
97LIMK10.53463141
98RPS6KA60.53273915
99TRPM70.52916150
100PRKD20.49930215
101NME10.49852264
102PDGFRB0.49633833
103NTRK30.48636791
104MARK30.48043710
105ERBB20.47818917
106PRKCZ0.47546253
107PRKCH0.47491836
108STK38L0.47050800
109TEC0.46789327
110ADRBK10.46232822
111PRKCQ0.45643558
112TBK10.45638069
113RPS6KC10.45297076
114RPS6KL10.45297076
115DAPK20.44596883
116MAP3K80.44077129
117MET0.43640430
118TGFBR20.42653835
119TTK0.42525889
120ROCK20.42323123
121MAP3K30.41270300
122AURKB0.41053024
123PLK20.40730996
124NLK0.39919328
125RIPK40.37724307
126STK380.37532540
127FER0.37102365
128BTK0.37074419
129TNK20.36555830
130KSR10.36548026
131PTK2B0.36326732
132IGF1R0.36198499
133MKNK20.35983587
134MAP4K10.34800222
135SYK0.34749218
136WNK40.34650939
137SGK2230.34388357
138SGK4940.34388357
139CSNK1G10.34369292
140VRK10.34349718
141PRKG10.33751573
142CAMK40.33611525
143PAK30.33560296
144FGFR30.32996585
145PDK10.32179249
146MAPK120.31998356
147MAP2K60.31677895
148ERN10.31569732
149RET0.30322261
150MUSK0.30212488
151CAMK2A0.29812972
152FES0.29712709
153MAP3K20.29109640
154RPS6KA50.27680242
155MAPK10.27058245
156PIK3CG0.26808974
157OBSCN0.26763739
158MAPK70.26514063
159ROCK10.26379721
160FGR0.26342095
161DYRK1A0.25066043
162ABL10.23291437
163TRIB30.23120523
164DAPK30.21779819
165KDR0.21656574
166PLK10.21383511
167TAOK30.20133281
168MATK0.19726637
169HIPK20.19328836
170PRKCA0.19086520

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.54291934
2Oxidative phosphorylation_Homo sapiens_hsa001902.58189200
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.57410736
4Graft-versus-host disease_Homo sapiens_hsa053322.50159304
5Glycosaminoglycan degradation_Homo sapiens_hsa005312.25489007
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.12091119
7Protein export_Homo sapiens_hsa030602.11686142
8Autoimmune thyroid disease_Homo sapiens_hsa053202.02960555
9Nicotine addiction_Homo sapiens_hsa050332.01579376
10Allograft rejection_Homo sapiens_hsa053302.01356064
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.00341152
12Fanconi anemia pathway_Homo sapiens_hsa034601.98496736
13Non-homologous end-joining_Homo sapiens_hsa034501.96596246
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.91004979
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.83705520
16Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.78080492
17Tryptophan metabolism_Homo sapiens_hsa003801.77520749
18Alzheimers disease_Homo sapiens_hsa050101.76013801
19Lysosome_Homo sapiens_hsa041421.74719122
20Parkinsons disease_Homo sapiens_hsa050121.71462742
21Sphingolipid metabolism_Homo sapiens_hsa006001.67995309
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.66502215
23RNA polymerase_Homo sapiens_hsa030201.61531937
24Axon guidance_Homo sapiens_hsa043601.59654743
25One carbon pool by folate_Homo sapiens_hsa006701.57581279
26Circadian rhythm_Homo sapiens_hsa047101.55932826
27Type II diabetes mellitus_Homo sapiens_hsa049301.52598526
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.50903316
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.48158987
30Huntingtons disease_Homo sapiens_hsa050161.47402571
31Vascular smooth muscle contraction_Homo sapiens_hsa042701.46143359
32Homologous recombination_Homo sapiens_hsa034401.45085714
33Rheumatoid arthritis_Homo sapiens_hsa053231.44487242
34Type I diabetes mellitus_Homo sapiens_hsa049401.42422567
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.36070404
36Selenocompound metabolism_Homo sapiens_hsa004501.34353181
37Arachidonic acid metabolism_Homo sapiens_hsa005901.34201601
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.32485594
39Fatty acid elongation_Homo sapiens_hsa000621.31816554
40Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.29066909
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.28090144
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.27343094
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.25912867
44Staphylococcus aureus infection_Homo sapiens_hsa051501.25159050
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.22252184
46Ether lipid metabolism_Homo sapiens_hsa005651.22050952
47Salivary secretion_Homo sapiens_hsa049701.20937084
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.19306670
49Vibrio cholerae infection_Homo sapiens_hsa051101.16832456
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16050650
51Steroid biosynthesis_Homo sapiens_hsa001001.13128961
52Pyrimidine metabolism_Homo sapiens_hsa002401.12999669
53ABC transporters_Homo sapiens_hsa020101.12949905
54Morphine addiction_Homo sapiens_hsa050321.09917953
55Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.08475934
56Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.03352277
57Serotonergic synapse_Homo sapiens_hsa047261.02928919
58Nitrogen metabolism_Homo sapiens_hsa009101.02214443
59Tight junction_Homo sapiens_hsa045300.99774321
60Asthma_Homo sapiens_hsa053100.99633396
61Pertussis_Homo sapiens_hsa051330.98697082
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.98184110
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.97953695
64Platelet activation_Homo sapiens_hsa046110.97529202
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.97395252
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.96249256
67Other glycan degradation_Homo sapiens_hsa005110.95111931
68Acute myeloid leukemia_Homo sapiens_hsa052210.94346809
69Complement and coagulation cascades_Homo sapiens_hsa046100.93410953
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.93325144
71Phototransduction_Homo sapiens_hsa047440.92411545
72Peroxisome_Homo sapiens_hsa041460.88767907
73Histidine metabolism_Homo sapiens_hsa003400.86018806
74Arginine biosynthesis_Homo sapiens_hsa002200.85843476
75DNA replication_Homo sapiens_hsa030300.84793849
76Collecting duct acid secretion_Homo sapiens_hsa049660.81587653
77Insulin resistance_Homo sapiens_hsa049310.81339094
78Chemical carcinogenesis_Homo sapiens_hsa052040.79870953
79Lysine degradation_Homo sapiens_hsa003100.78629184
80Small cell lung cancer_Homo sapiens_hsa052220.76139942
81Cardiac muscle contraction_Homo sapiens_hsa042600.75918300
82Purine metabolism_Homo sapiens_hsa002300.72694062
83mTOR signaling pathway_Homo sapiens_hsa041500.71709228
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71564043
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.71245010
86Glutamatergic synapse_Homo sapiens_hsa047240.69115050
87Phenylalanine metabolism_Homo sapiens_hsa003600.68898099
88MAPK signaling pathway_Homo sapiens_hsa040100.68770392
89Taste transduction_Homo sapiens_hsa047420.68670278
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68486930
91Hepatitis C_Homo sapiens_hsa051600.66766181
92Olfactory transduction_Homo sapiens_hsa047400.65045951
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.63529369
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63527892
95B cell receptor signaling pathway_Homo sapiens_hsa046620.63214562
96Mismatch repair_Homo sapiens_hsa034300.62713163
97Basal transcription factors_Homo sapiens_hsa030220.62385999
98Notch signaling pathway_Homo sapiens_hsa043300.61646203
99Hematopoietic cell lineage_Homo sapiens_hsa046400.61379509
100Nucleotide excision repair_Homo sapiens_hsa034200.60611056
101Dorso-ventral axis formation_Homo sapiens_hsa043200.60220837
102NOD-like receptor signaling pathway_Homo sapiens_hsa046210.59273428
103GABAergic synapse_Homo sapiens_hsa047270.58733399
104Toxoplasmosis_Homo sapiens_hsa051450.58724863
105Vitamin digestion and absorption_Homo sapiens_hsa049770.58013689
106Spliceosome_Homo sapiens_hsa030400.57860892
107Glutathione metabolism_Homo sapiens_hsa004800.57696102
108Ras signaling pathway_Homo sapiens_hsa040140.56764653
109Phagosome_Homo sapiens_hsa041450.55346558
110Retinol metabolism_Homo sapiens_hsa008300.54380033
111Malaria_Homo sapiens_hsa051440.54319276
112Cyanoamino acid metabolism_Homo sapiens_hsa004600.53834034
113Circadian entrainment_Homo sapiens_hsa047130.53023128
114Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51096349
115ECM-receptor interaction_Homo sapiens_hsa045120.50953232
116Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.50787053
117Proteasome_Homo sapiens_hsa030500.50591153
118Linoleic acid metabolism_Homo sapiens_hsa005910.49913325
119PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48843482
120Oxytocin signaling pathway_Homo sapiens_hsa049210.48080393
121Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48023061
122Fatty acid biosynthesis_Homo sapiens_hsa000610.47935374
123Basal cell carcinoma_Homo sapiens_hsa052170.47811410
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46895502
125Synaptic vesicle cycle_Homo sapiens_hsa047210.46349717
126Drug metabolism - other enzymes_Homo sapiens_hsa009830.46164305
127Renin secretion_Homo sapiens_hsa049240.46128681
128Toll-like receptor signaling pathway_Homo sapiens_hsa046200.46127500
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46107120
130Calcium signaling pathway_Homo sapiens_hsa040200.45942338
131Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45041733
132Base excision repair_Homo sapiens_hsa034100.44846749
133NF-kappa B signaling pathway_Homo sapiens_hsa040640.44073679
134Cysteine and methionine metabolism_Homo sapiens_hsa002700.43861718
135Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43368130
136Arginine and proline metabolism_Homo sapiens_hsa003300.43153602
137Viral myocarditis_Homo sapiens_hsa054160.42551526
138Focal adhesion_Homo sapiens_hsa045100.41710638
139Systemic lupus erythematosus_Homo sapiens_hsa053220.40632136
140Long-term depression_Homo sapiens_hsa047300.40571456
141Osteoclast differentiation_Homo sapiens_hsa043800.40430550
142Renal cell carcinoma_Homo sapiens_hsa052110.38961664
143Tyrosine metabolism_Homo sapiens_hsa003500.38867368
144Mineral absorption_Homo sapiens_hsa049780.37777636
145Insulin signaling pathway_Homo sapiens_hsa049100.37721642
146Shigellosis_Homo sapiens_hsa051310.37659711
147Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36515386
148Caffeine metabolism_Homo sapiens_hsa002320.36433259
149RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.35794343
150Bile secretion_Homo sapiens_hsa049760.35606326
151Cholinergic synapse_Homo sapiens_hsa047250.33952775
152beta-Alanine metabolism_Homo sapiens_hsa004100.33422110
153Ovarian steroidogenesis_Homo sapiens_hsa049130.33122689
154cAMP signaling pathway_Homo sapiens_hsa040240.31242834

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