

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | vitamin A metabolic process (GO:0006776) | 6.92560882 |
| 2 | regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081) | 6.75316390 |
| 3 | flavonoid metabolic process (GO:0009812) | 5.96736041 |
| 4 | actin filament depolymerization (GO:0030042) | 5.87765808 |
| 5 | sulfate transmembrane transport (GO:1902358) | 5.77788737 |
| 6 | drug catabolic process (GO:0042737) | 5.73242382 |
| 7 | virion attachment to host cell (GO:0019062) | 5.69040475 |
| 8 | adhesion of symbiont to host cell (GO:0044650) | 5.69040475 |
| 9 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 5.53632551 |
| 10 | phospholipid efflux (GO:0033700) | 5.28612608 |
| 11 | digestive system process (GO:0022600) | 5.27995060 |
| 12 | protein-lipid complex subunit organization (GO:0071825) | 5.25997236 |
| 13 | positive regulation of triglyceride lipase activity (GO:0061365) | 5.23236601 |
| 14 | positive regulation of lipoprotein lipase activity (GO:0051006) | 5.23236601 |
| 15 | regulation of triglyceride catabolic process (GO:0010896) | 5.20397320 |
| 16 | regulation of cholesterol esterification (GO:0010872) | 5.16915727 |
| 17 | regulation of guanylate cyclase activity (GO:0031282) | 5.11779878 |
| 18 | lipoprotein metabolic process (GO:0042157) | 5.10321326 |
| 19 | bundle of His cell to Purkinje myocyte communication (GO:0086069) | 4.99819844 |
| 20 | plasma lipoprotein particle assembly (GO:0034377) | 4.97184442 |
| 21 | sulfate transport (GO:0008272) | 4.81034231 |
| 22 | purine ribonucleoside bisphosphate metabolic process (GO:0034035) | 4.80985536 |
| 23 | 3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427) | 4.80985536 |
| 24 | cytidine deamination (GO:0009972) | 4.77060948 |
| 25 | cytidine metabolic process (GO:0046087) | 4.77060948 |
| 26 | cytidine catabolic process (GO:0006216) | 4.77060948 |
| 27 | adhesion of symbiont to host (GO:0044406) | 4.72138334 |
| 28 | modified amino acid transport (GO:0072337) | 4.71157939 |
| 29 | protein-lipid complex assembly (GO:0065005) | 4.69954432 |
| 30 | regulation of cellular extravasation (GO:0002691) | 4.58915946 |
| 31 | hormone catabolic process (GO:0042447) | 4.52440107 |
| 32 | glucose 6-phosphate metabolic process (GO:0051156) | 4.42502775 |
| 33 | regulation of lipoprotein metabolic process (GO:0050746) | 4.36211419 |
| 34 | sulfur compound transport (GO:0072348) | 4.36056386 |
| 35 | cholesterol efflux (GO:0033344) | 4.34687505 |
| 36 | very-low-density lipoprotein particle assembly (GO:0034379) | 4.32177254 |
| 37 | cellular response to hepatocyte growth factor stimulus (GO:0035729) | 4.28401459 |
| 38 | response to hepatocyte growth factor (GO:0035728) | 4.28401459 |
| 39 | bile acid and bile salt transport (GO:0015721) | 4.22841281 |
| 40 | regulation of bile acid biosynthetic process (GO:0070857) | 4.22519430 |
| 41 | diacylglycerol metabolic process (GO:0046339) | 4.18545654 |
| 42 | vitamin transmembrane transport (GO:0035461) | 4.18076768 |
| 43 | fructose metabolic process (GO:0006000) | 4.16924953 |
| 44 | digestion (GO:0007586) | 4.05913702 |
| 45 | transepithelial transport (GO:0070633) | 4.04861499 |
| 46 | NADH metabolic process (GO:0006734) | 4.02642622 |
| 47 | epoxygenase P450 pathway (GO:0019373) | 4.01408025 |
| 48 | UDP-N-acetylglucosamine metabolic process (GO:0006047) | 4.01145740 |
| 49 | intestinal epithelial cell development (GO:0060576) | 3.97861666 |
| 50 | desmosome organization (GO:0002934) | 3.94875303 |
| 51 | cholesterol homeostasis (GO:0042632) | 3.94418212 |
| 52 | drug metabolic process (GO:0017144) | 3.93370471 |
| 53 | negative regulation of lipase activity (GO:0060192) | 3.92578193 |
| 54 | glutamine family amino acid biosynthetic process (GO:0009084) | 3.91734292 |
| 55 | sterol homeostasis (GO:0055092) | 3.91039081 |
| 56 | peptide hormone processing (GO:0016486) | 3.90134966 |
| 57 | positive regulation of glycoprotein biosynthetic process (GO:0010560) | 3.88960243 |
| 58 | homocysteine metabolic process (GO:0050667) | 3.85921191 |
| 59 | cholesterol transport (GO:0030301) | 3.85352920 |
| 60 | sterol transport (GO:0015918) | 3.85352920 |
| 61 | lipoprotein transport (GO:0042953) | 3.77848788 |
| 62 | membrane repolarization during cardiac muscle cell action potential (GO:0086013) | 3.77744317 |
| 63 | transcytosis (GO:0045056) | 3.77696067 |
| 64 | L-ascorbic acid metabolic process (GO:0019852) | 3.76691045 |
| 65 | drinking behavior (GO:0042756) | 3.75332375 |
| 66 | sperm capacitation (GO:0048240) | 3.70331177 |
| 67 | regulation of calcineurin-NFAT signaling cascade (GO:0070884) | 3.69836999 |
| 68 | positive regulation of guanylate cyclase activity (GO:0031284) | 3.68557956 |
| 69 | fat-soluble vitamin biosynthetic process (GO:0042362) | 3.68302181 |
| 70 | negative regulation of cholesterol transport (GO:0032375) | 3.68287322 |
| 71 | negative regulation of sterol transport (GO:0032372) | 3.68287322 |
| 72 | negative regulation of fatty acid biosynthetic process (GO:0045717) | 3.68195851 |
| 73 | peptide catabolic process (GO:0043171) | 3.65969029 |
| 74 | regulation of triglyceride metabolic process (GO:0090207) | 3.63433750 |
| 75 | positive regulation of respiratory burst (GO:0060267) | 3.62990390 |
| 76 | phospholipase C-activating dopamine receptor signaling pathway (GO:0060158) | 3.61595097 |
| 77 | reverse cholesterol transport (GO:0043691) | 3.58801004 |
| 78 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 3.55831539 |
| 79 | bicarbonate transport (GO:0015701) | 3.54206141 |
| 80 | response to hydroperoxide (GO:0033194) | 3.53651423 |
| 81 | positive regulation of fatty acid biosynthetic process (GO:0045723) | 3.51913575 |
| 82 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338) | 3.51319749 |
| 83 | low-density lipoprotein particle remodeling (GO:0034374) | 3.51037326 |
| 84 | urea cycle (GO:0000050) | 3.48112230 |
| 85 | urea metabolic process (GO:0019627) | 3.48112230 |
| 86 | exogenous drug catabolic process (GO:0042738) | 3.46976145 |
| 87 | positive regulation of triglyceride metabolic process (GO:0090208) | 3.45500065 |
| 88 | phenylpropanoid metabolic process (GO:0009698) | 3.44930121 |
| 89 | regulation of digestive system process (GO:0044058) | 3.42153249 |
| 90 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 3.41021023 |
| 91 | positive regulation of glycoprotein metabolic process (GO:1903020) | 3.40251956 |
| 92 | sulfation (GO:0051923) | 3.37972009 |
| 93 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 3.37932380 |
| 94 | oligosaccharide catabolic process (GO:0009313) | 3.37541271 |
| 95 | maintenance of gastrointestinal epithelium (GO:0030277) | 3.37531270 |
| 96 | disruption of cells of other organism (GO:0044364) | 3.37310116 |
| 97 | killing of cells of other organism (GO:0031640) | 3.37310116 |
| 98 | regulation of systemic arterial blood pressure (GO:0003073) | 3.34816132 |
| 99 | cellular response to nitric oxide (GO:0071732) | 3.34671688 |
| 100 | cellular response to zinc ion (GO:0071294) | 3.33674065 |
| 101 | glomerular filtration (GO:0003094) | 3.33647222 |
| 102 | antibacterial humoral response (GO:0019731) | 3.33627930 |
| 103 | membrane repolarization during action potential (GO:0086011) | 3.32148626 |
| 104 | activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO | 3.32033007 |
| 105 | antimicrobial humoral response (GO:0019730) | 3.30677332 |
| 106 | auditory receptor cell differentiation (GO:0042491) | 3.29491379 |
| 107 | innate immune response in mucosa (GO:0002227) | 3.29124737 |
| 108 | primary alcohol catabolic process (GO:0034310) | 3.28475810 |
| 109 | regulation of systemic arterial blood pressure by hormone (GO:0001990) | 3.28332332 |
| 110 | regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044) | 3.28332332 |
| 111 | endocrine process (GO:0050886) | 3.28332332 |
| 112 | defense response to fungus (GO:0050832) | 3.26910058 |
| 113 | cellular glucuronidation (GO:0052695) | 3.26591166 |
| 114 | phosphatidylglycerol acyl-chain remodeling (GO:0036148) | 3.25122841 |
| 115 | high-density lipoprotein particle remodeling (GO:0034375) | 3.24461974 |
| 116 | ethanol metabolic process (GO:0006067) | 3.21279922 |
| 117 | plasma lipoprotein particle clearance (GO:0034381) | 3.20895090 |
| 118 | receptor guanylyl cyclase signaling pathway (GO:0007168) | 3.19975661 |
| 119 | regulation of cholesterol homeostasis (GO:2000188) | 3.18919712 |
| 120 | antigen processing and presentation of endogenous antigen (GO:0019883) | 3.18892768 |
| 121 | acylglycerol homeostasis (GO:0055090) | 3.18825428 |
| 122 | triglyceride homeostasis (GO:0070328) | 3.18825428 |
| 123 | protein-lipid complex remodeling (GO:0034368) | 3.16412139 |
| 124 | macromolecular complex remodeling (GO:0034367) | 3.16412139 |
| 125 | plasma lipoprotein particle remodeling (GO:0034369) | 3.16412139 |
| 126 | ventricular cardiac muscle cell action potential (GO:0086005) | 3.12027513 |
| 127 | hepatocyte apoptotic process (GO:0097284) | 3.11542729 |
| 128 | positive regulation of lipid catabolic process (GO:0050996) | 3.11062246 |
| 129 | plasma lipoprotein particle organization (GO:0071827) | 3.10972349 |
| 130 | polyol transport (GO:0015791) | 3.10613664 |
| 131 | regulation of cGMP biosynthetic process (GO:0030826) | 3.08320818 |
| 132 | removal of superoxide radicals (GO:0019430) | 3.07810209 |
| 133 | cellular response to superoxide (GO:0071451) | 3.07810209 |
| 134 | cellular response to oxygen radical (GO:0071450) | 3.07810209 |
| 135 | fat-soluble vitamin metabolic process (GO:0006775) | 3.07117386 |
| 136 | cellular response to reactive nitrogen species (GO:1902170) | 3.05270570 |
| 137 | response to nitric oxide (GO:0071731) | 3.01643023 |
| 138 | vitamin transport (GO:0051180) | 3.01290029 |
| 139 | arginine metabolic process (GO:0006525) | 2.99833997 |
| 140 | regulation of fatty acid biosynthetic process (GO:0042304) | 2.98366816 |
| 141 | regulation of sterol transport (GO:0032371) | 2.97026890 |
| 142 | regulation of cholesterol transport (GO:0032374) | 2.97026890 |
| 143 | renal filtration (GO:0097205) | 2.95525458 |
| 144 | intestinal absorption (GO:0050892) | 12.0255908 |
| 145 | intestinal cholesterol absorption (GO:0030299) | 11.4179487 |
| 146 | angiotensin maturation (GO:0002003) | 10.4490865 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 8.30961707 |
| 2 | CDX2_20551321_ChIP-Seq_CACO-2_Human | 6.11584823 |
| 3 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 3.95291415 |
| 4 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 3.88609329 |
| 5 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 3.41126914 |
| 6 | GATA4_25053715_ChIP-Seq_YYC3_Human | 3.31235535 |
| 7 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 3.19616530 |
| 8 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 3.18510235 |
| 9 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 3.03474819 |
| 10 | SOX2_20726797_ChIP-Seq_SW620_Human | 3.02141343 |
| 11 | GATA6_25053715_ChIP-Seq_YYC3_Human | 2.90316997 |
| 12 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 2.87629017 |
| 13 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 2.66512761 |
| 14 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.66030315 |
| 15 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 2.55916683 |
| 16 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 2.41650406 |
| 17 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 2.41029450 |
| 18 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 2.40617999 |
| 19 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 2.17106070 |
| 20 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 2.10733512 |
| 21 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.84230421 |
| 22 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.83607817 |
| 23 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.83421717 |
| 24 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 1.83324479 |
| 25 | KLF5_25053715_ChIP-Seq_YYC3_Human | 1.77117550 |
| 26 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.76125811 |
| 27 | TCF4_18268006_ChIP-ChIP_LS174T_Human | 1.68922803 |
| 28 | VDR_22108803_ChIP-Seq_LS180_Human | 1.63973166 |
| 29 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.63599733 |
| 30 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 1.61838854 |
| 31 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.55000160 |
| 32 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 1.51601353 |
| 33 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.50762960 |
| 34 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.50512290 |
| 35 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.48349765 |
| 36 | SA1_27219007_Chip-Seq_Bcells_Human | 1.46399183 |
| 37 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.43692505 |
| 38 | HNF4A_19822575_ChIP-Seq_HepG2_Human | 1.42611307 |
| 39 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.42538636 |
| 40 | RUNX1_27514584_Chip-Seq_MCF-7_Human | 1.39393889 |
| 41 | GATA2_19941826_ChIP-Seq_K562_Human | 1.36456492 |
| 42 | FOXA1_25552417_ChIP-Seq_VCAP_Human | 1.35639178 |
| 43 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.35464417 |
| 44 | ATF3_27146783_Chip-Seq_COLON_Human | 1.32016422 |
| 45 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.25824919 |
| 46 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.25441831 |
| 47 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.23906347 |
| 48 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.23264222 |
| 49 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.22860830 |
| 50 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 1.22848524 |
| 51 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.21616101 |
| 52 | ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.20665170 |
| 53 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.20274183 |
| 54 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.19531451 |
| 55 | JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.18105518 |
| 56 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.16402810 |
| 57 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.14414752 |
| 58 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 1.13979798 |
| 59 | CDX2_22108803_ChIP-Seq_LS180_Human | 1.13573732 |
| 60 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.13368709 |
| 61 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.12674553 |
| 62 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.11937767 |
| 63 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.10161953 |
| 64 | TAF2_19829295_ChIP-Seq_ESCs_Human | 1.09017280 |
| 65 | NANOG_20526341_ChIP-Seq_ESCs_Human | 1.07913634 |
| 66 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.07490874 |
| 67 | CEBPB_22108803_ChIP-Seq_LS180_Human | 1.07316076 |
| 68 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 1.06656331 |
| 69 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.06465074 |
| 70 | CREB1_26743006_Chip-Seq_LNCaP_Human | 1.06410997 |
| 71 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 1.05219910 |
| 72 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 1.04877744 |
| 73 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.04593274 |
| 74 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.03084881 |
| 75 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.02151431 |
| 76 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 1.00992351 |
| 77 | RXR_22108803_ChIP-Seq_LS180_Human | 0.99357606 |
| 78 | GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.99040152 |
| 79 | EGR1_19032775_ChIP-ChIP_M12_Human | 0.98851259 |
| 80 | RAD21_21589869_ChIP-Seq_MESCs_Mouse | 0.98712266 |
| 81 | P300_27268052_Chip-Seq_Bcells_Human | 0.98640506 |
| 82 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.98187285 |
| 83 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.97800145 |
| 84 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.97679999 |
| 85 | CLOCK_20551151_ChIP-Seq_293T_Human | 0.97521104 |
| 86 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 0.95520990 |
| 87 | CTCF_20526341_ChIP-Seq_ESCs_Human | 0.95380469 |
| 88 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.94987199 |
| 89 | SOX2_22085726_ChIP-Seq_NPCs_Mouse | 0.94342004 |
| 90 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.93697164 |
| 91 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 0.93535888 |
| 92 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 0.93414346 |
| 93 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 0.93414346 |
| 94 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.92639559 |
| 95 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.92639559 |
| 96 | GATA1_22025678_ChIP-Seq_K562_Human | 0.92318091 |
| 97 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 0.92102056 |
| 98 | E2F1_20622854_ChIP-Seq_HELA_Human | 0.91854212 |
| 99 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 0.91087650 |
| 100 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 0.90160989 |
| 101 | HNFA_21074721_ChIP-Seq_CACO-2_Human | 0.88713814 |
| 102 | FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.88305368 |
| 103 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 0.88142203 |
| 104 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 0.87444224 |
| 105 | CDX2_21074721_ChIP-Seq_CACO-2_Mouse | 0.86507772 |
| 106 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.85879020 |
| 107 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 0.85551141 |
| 108 | FOXH1_21741376_ChIP-Seq_ESCs_Human | 0.84625208 |
| 109 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.84433172 |
| 110 | P68_20966046_ChIP-Seq_HELA_Human | 0.84157541 |
| 111 | PHF8_20622853_ChIP-Seq_HELA_Human | 0.83496488 |
| 112 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.82939326 |
| 113 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.82022305 |
| 114 | AR_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.81967193 |
| 115 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 0.81895673 |
| 116 | FOXM1_26456572_ChIP-Seq_MCF-7_Human | 0.81739659 |
| 117 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.81705648 |
| 118 | TP63_22573176_ChIP-Seq_HFKS_Human | 0.81627895 |
| 119 | WDR5_24793694_ChIP-Seq_LNCAP_Human | 0.81384654 |
| 120 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 0.80991098 |
| 121 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 0.80847177 |
| 122 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.80546193 |
| 123 | NFYA_21822215_ChIP-Seq_K562_Human | 0.80544377 |
| 124 | CBP_21632823_ChIP-Seq_H3396_Human | 0.80510990 |
| 125 | RAC3_21632823_ChIP-Seq_H3396_Human | 0.80479652 |
| 126 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 0.80447365 |
| 127 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.80134384 |
| 128 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.80017490 |
| 129 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.79783608 |
| 130 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 0.79606372 |
| 131 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.78983353 |
| 132 | PCGF4_22325352_ChIP-Seq_293T-Rex_Human | 0.78905289 |
| 133 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 0.78706872 |
| 134 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.78500330 |
| 135 | ERA_21632823_ChIP-Seq_H3396_Human | 0.78493185 |
| 136 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.78122919 |
| 137 | EBNA1_20929547_Chip-Seq_RAJI-cells_Human | 0.77202171 |
| 138 | JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse | 0.76613624 |
| 139 | P63_26484246_Chip-Seq_KERATINOCYTES_Human | 0.75944557 |
| 140 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 0.75921860 |
| 141 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 0.75741143 |
| 142 | PHF8_20622854_ChIP-Seq_HELA_Human | 0.75457202 |
| 143 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.75226669 |
| 144 | MYC_19829295_ChIP-Seq_ESCs_Human | 0.75126589 |
| 145 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 0.74646453 |
| 146 | SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.73298579 |
| 147 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.73288544 |
| 148 | JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.73279053 |
| 149 | GATA3_24758297_ChIP-Seq_MCF-7_Human | 0.73130092 |
| 150 | RARA_24833708_ChIP-Seq_LIVER_Mouse | 0.72997945 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0005360_urolithiasis | 9.63312437 |
| 2 | MP0001666_abnormal_nutrient_absorption | 5.61931475 |
| 3 | MP0010234_abnormal_vibrissa_follicle | 5.18195796 |
| 4 | MP0002139_abnormal_hepatobiliary_system | 3.89076754 |
| 5 | MP0009840_abnormal_foam_cell | 3.80134210 |
| 6 | MP0000462_abnormal_digestive_system | 3.49131908 |
| 7 | MP0004264_abnormal_extraembryonic_tissu | 3.26433320 |
| 8 | MP0005085_abnormal_gallbladder_physiolo | 3.22917328 |
| 9 | MP0003252_abnormal_bile_duct | 2.93658255 |
| 10 | MP0003866_abnormal_defecation | 2.79553913 |
| 11 | MP0009379_abnormal_foot_pigmentation | 2.75448424 |
| 12 | MP0003183_abnormal_peptide_metabolism | 2.74883539 |
| 13 | MP0008875_abnormal_xenobiotic_pharmacok | 2.62902598 |
| 14 | MP0010329_abnormal_lipoprotein_level | 2.54863730 |
| 15 | MP0002822_catalepsy | 2.17244260 |
| 16 | MP0001873_stomach_inflammation | 2.16838383 |
| 17 | MP0001663_abnormal_digestive_system | 2.12768139 |
| 18 | MP0005381_digestive/alimentary_phenotyp | 2.03995360 |
| 19 | MP0004019_abnormal_vitamin_homeostasis | 2.03446691 |
| 20 | MP0004147_increased_porphyrin_level | 2.01755726 |
| 21 | MP0010155_abnormal_intestine_physiology | 1.92251464 |
| 22 | MP0000490_abnormal_crypts_of | 1.92049012 |
| 23 | MP0001664_abnormal_digestion | 1.91604627 |
| 24 | MP0003300_gastrointestinal_ulcer | 1.88745301 |
| 25 | MP0005365_abnormal_bile_salt | 1.81647662 |
| 26 | MP0005084_abnormal_gallbladder_morpholo | 1.77778319 |
| 27 | MP0000537_abnormal_urethra_morphology | 1.72036220 |
| 28 | MP0004858_abnormal_nervous_system | 1.71857605 |
| 29 | MP0000477_abnormal_intestine_morphology | 1.70616327 |
| 30 | MP0008004_abnormal_stomach_pH | 1.66557865 |
| 31 | MP0002254_reproductive_system_inflammat | 1.66293178 |
| 32 | MP0005377_hearing/vestibular/ear_phenot | 1.61952665 |
| 33 | MP0003878_abnormal_ear_physiology | 1.61952665 |
| 34 | MP0010352_gastrointestinal_tract_polyps | 1.61865565 |
| 35 | MP0003879_abnormal_hair_cell | 1.57353900 |
| 36 | MP0000538_abnormal_urinary_bladder | 1.54148271 |
| 37 | MP0002089_abnormal_postnatal_growth/wei | 1.39383643 |
| 38 | MP0005448_abnormal_energy_balance | 1.37299950 |
| 39 | MP0003705_abnormal_hypodermis_morpholog | 1.32940556 |
| 40 | MP0002277_abnormal_respiratory_mucosa | 1.29284709 |
| 41 | MP0006054_spinal_hemorrhage | 1.25922104 |
| 42 | MP0005670_abnormal_white_adipose | 1.21743951 |
| 43 | MP0004043_abnormal_pH_regulation | 1.20848286 |
| 44 | MP0002796_impaired_skin_barrier | 1.20713852 |
| 45 | MP0002971_abnormal_brown_adipose | 1.18674661 |
| 46 | MP0003191_abnormal_cellular_cholesterol | 1.17411836 |
| 47 | MP0001501_abnormal_sleep_pattern | 1.15912094 |
| 48 | MP0005174_abnormal_tail_pigmentation | 1.15340760 |
| 49 | MP0005332_abnormal_amino_acid | 1.13619412 |
| 50 | MP0003806_abnormal_nucleotide_metabolis | 1.11027583 |
| 51 | MP0004782_abnormal_surfactant_physiolog | 1.06614853 |
| 52 | MP0009643_abnormal_urine_homeostasis | 1.05511682 |
| 53 | MP0000604_amyloidosis | 1.03399491 |
| 54 | MP0001958_emphysema | 1.02728342 |
| 55 | MP0010678_abnormal_skin_adnexa | 0.99313410 |
| 56 | MP0000249_abnormal_blood_vessel | 0.98813449 |
| 57 | MP0001485_abnormal_pinna_reflex | 0.98598584 |
| 58 | MP0001756_abnormal_urination | 0.94952448 |
| 59 | MP0002118_abnormal_lipid_homeostasis | 0.94421519 |
| 60 | MP0008872_abnormal_physiological_respon | 0.93002953 |
| 61 | MP0005535_abnormal_body_temperature | 0.92145634 |
| 62 | MP0002734_abnormal_mechanical_nocicepti | 0.91165039 |
| 63 | MP0003718_maternal_effect | 0.86665131 |
| 64 | MP0004145_abnormal_muscle_electrophysio | 0.86294380 |
| 65 | MP0005451_abnormal_body_composition | 0.84185077 |
| 66 | MP0000566_synostosis | 0.84136090 |
| 67 | MP0003453_abnormal_keratinocyte_physiol | 0.83579665 |
| 68 | MP0002876_abnormal_thyroid_physiology | 0.83094631 |
| 69 | MP0009115_abnormal_fat_cell | 0.82780430 |
| 70 | MP0003329_amyloid_beta_deposits | 0.82335610 |
| 71 | MP0003868_abnormal_feces_composition | 0.81743517 |
| 72 | MP0004947_skin_inflammation | 0.81119582 |
| 73 | MP0000609_abnormal_liver_physiology | 0.80960247 |
| 74 | MP0009697_abnormal_copulation | 0.80178649 |
| 75 | MP0001845_abnormal_inflammatory_respons | 0.79851898 |
| 76 | MP0001835_abnormal_antigen_presentation | 0.79093947 |
| 77 | MP0004270_analgesia | 0.77432516 |
| 78 | MP0000467_abnormal_esophagus_morphology | 0.75784029 |
| 79 | MP0005166_decreased_susceptibility_to | 0.73348496 |
| 80 | MP0003950_abnormal_plasma_membrane | 0.71998087 |
| 81 | MP0000516_abnormal_urinary_system | 0.71319196 |
| 82 | MP0005367_renal/urinary_system_phenotyp | 0.71319196 |
| 83 | MP0000470_abnormal_stomach_morphology | 0.70932230 |
| 84 | MP0005501_abnormal_skin_physiology | 0.70509171 |
| 85 | MP0001765_abnormal_ion_homeostasis | 0.69539411 |
| 86 | MP0002098_abnormal_vibrissa_morphology | 0.68844380 |
| 87 | MP0005167_abnormal_blood-brain_barrier | 0.67486439 |
| 88 | MP0002998_abnormal_bone_remodeling | 0.65562418 |
| 89 | MP0001188_hyperpigmentation | 0.65204257 |
| 90 | MP0000681_abnormal_thyroid_gland | 0.64660691 |
| 91 | MP0005395_other_phenotype | 0.64050580 |
| 92 | MP0001849_ear_inflammation | 0.63027971 |
| 93 | MP0000613_abnormal_salivary_gland | 0.62571406 |
| 94 | MP0005666_abnormal_adipose_tissue | 0.61962471 |
| 95 | MP0000427_abnormal_hair_cycle | 0.61676090 |
| 96 | MP0005025_abnormal_response_to | 0.61257725 |
| 97 | MP0002078_abnormal_glucose_homeostasis | 0.60607256 |
| 98 | MP0009053_abnormal_anal_canal | 0.60551664 |
| 99 | MP0005319_abnormal_enzyme/_coenzyme | 0.59521235 |
| 100 | MP0005387_immune_system_phenotype | 0.58481719 |
| 101 | MP0001790_abnormal_immune_system | 0.58481719 |
| 102 | MP0008469_abnormal_protein_level | 0.58233408 |
| 103 | MP0009333_abnormal_splenocyte_physiolog | 0.57858299 |
| 104 | MP0002136_abnormal_kidney_physiology | 0.56864534 |
| 105 | MP0003953_abnormal_hormone_level | 0.55966655 |
| 106 | MP0005334_abnormal_fat_pad | 0.54852884 |
| 107 | MP0000230_abnormal_systemic_arterial | 0.54031289 |
| 108 | MP0001216_abnormal_epidermal_layer | 0.53831755 |
| 109 | MP0005409_darkened_coat_color | 0.53426640 |
| 110 | MP0002138_abnormal_hepatobiliary_system | 0.53341980 |
| 111 | MP0002896_abnormal_bone_mineralization | 0.52018543 |
| 112 | MP0003436_decreased_susceptibility_to | 0.51629626 |
| 113 | MP0002638_abnormal_pupillary_reflex | 0.51476993 |
| 114 | MP0000015_abnormal_ear_pigmentation | 0.51114662 |
| 115 | MP0005636_abnormal_mineral_homeostasis | 0.50905599 |
| 116 | MP0001533_abnormal_skeleton_physiology | 0.50255813 |
| 117 | MP0003724_increased_susceptibility_to | 0.48497774 |
| 118 | MP0005058_abnormal_lysosome_morphology | 0.48492175 |
| 119 | MP0009384_cardiac_valve_regurgitation | 0.47722848 |
| 120 | MP0009642_abnormal_blood_homeostasis | 0.47687153 |
| 121 | MP0000678_abnormal_parathyroid_gland | 0.46158326 |
| 122 | MP0009765_abnormal_xenobiotic_induced | 0.45445967 |
| 123 | MP0009780_abnormal_chondrocyte_physiolo | 0.44695340 |
| 124 | MP0001764_abnormal_homeostasis | 0.44415649 |
| 125 | MP0005266_abnormal_metabolism | 0.42565174 |
| 126 | MP0001191_abnormal_skin_condition | 0.40766751 |
| 127 | MP0010386_abnormal_urinary_bladder | 0.40354867 |
| 128 | MP0005310_abnormal_salivary_gland | 0.40331349 |
| 129 | MP0009785_altered_susceptibility_to | 0.40199842 |
| 130 | MP0003938_abnormal_ear_development | 0.40095541 |
| 131 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.39791334 |
| 132 | MP0006082_CNS_inflammation | 0.39471198 |
| 133 | MP0003638_abnormal_response/metabolism_ | 0.39083506 |
| 134 | MP0003693_abnormal_embryo_hatching | 0.38958841 |
| 135 | MP0002060_abnormal_skin_morphology | 0.37555454 |
| 136 | MP0000377_abnormal_hair_follicle | 0.36321104 |
| 137 | MP0003283_abnormal_digestive_organ | 0.35751881 |
| 138 | MP0010771_integument_phenotype | 0.35344267 |
| 139 | MP0005464_abnormal_platelet_physiology | 0.33841052 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ileus (HP:0002595) | 8.54350075 |
| 2 | Acanthocytosis (HP:0001927) | 6.67563006 |
| 3 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 6.66311363 |
| 4 | Malnutrition (HP:0004395) | 6.22182918 |
| 5 | Hypobetalipoproteinemia (HP:0003563) | 6.16179627 |
| 6 | Right ventricular cardiomyopathy (HP:0011663) | 5.44446634 |
| 7 | Systemic lupus erythematosus (HP:0002725) | 5.24484911 |
| 8 | Hyperlipoproteinemia (HP:0010980) | 5.04575333 |
| 9 | Conjugated hyperbilirubinemia (HP:0002908) | 4.84156605 |
| 10 | Abnormality of proline metabolism (HP:0010907) | 4.57319206 |
| 11 | Hydroxyprolinuria (HP:0003080) | 4.57319206 |
| 12 | Congenital sensorineural hearing impairment (HP:0008527) | 4.25910609 |
| 13 | Autoimmune thrombocytopenia (HP:0001973) | 4.16806679 |
| 14 | Abnormality of pyrimidine metabolism (HP:0004353) | 4.03563477 |
| 15 | Ventricular fibrillation (HP:0001663) | 3.93627084 |
| 16 | Cupped ribs (HP:0000887) | 3.91117607 |
| 17 | Poikilocytosis (HP:0004447) | 3.88350442 |
| 18 | Fat malabsorption (HP:0002630) | 3.86719760 |
| 19 | Pigmentary retinal degeneration (HP:0001146) | 3.83463269 |
| 20 | Abdominal distention (HP:0003270) | 3.73660888 |
| 21 | Vascular calcification (HP:0004934) | 3.70678715 |
| 22 | Chronic diarrhea (HP:0002028) | 3.52342014 |
| 23 | Hypolipoproteinemia (HP:0010981) | 3.42196323 |
| 24 | Syncope (HP:0001279) | 3.38880610 |
| 25 | Cardiovascular calcification (HP:0011915) | 3.24043753 |
| 26 | Abnormality of urine glucose concentration (HP:0011016) | 3.18688342 |
| 27 | Glycosuria (HP:0003076) | 3.18688342 |
| 28 | Abnormality of magnesium homeostasis (HP:0004921) | 3.17764506 |
| 29 | Gastrointestinal dysmotility (HP:0002579) | 3.16043687 |
| 30 | Widely patent fontanelles and sutures (HP:0004492) | 3.15233308 |
| 31 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 3.14862103 |
| 32 | Autoimmune hemolytic anemia (HP:0001890) | 3.08083521 |
| 33 | Villous atrophy (HP:0011473) | 3.06165300 |
| 34 | Abnormality of small intestinal villus morphology (HP:0011472) | 3.06165300 |
| 35 | Facial shape deformation (HP:0011334) | 3.03987743 |
| 36 | Potter facies (HP:0002009) | 3.03987743 |
| 37 | Flat acetabular roof (HP:0003180) | 3.01053666 |
| 38 | Vacuolated lymphocytes (HP:0001922) | 3.00431295 |
| 39 | Hyperphosphatemia (HP:0002905) | 2.98838499 |
| 40 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 2.97968843 |
| 41 | Woolly hair (HP:0002224) | 2.95321316 |
| 42 | Glomerulonephritis (HP:0000099) | 2.95036859 |
| 43 | Abnormality of nucleobase metabolism (HP:0010932) | 2.93028400 |
| 44 | Dehydration (HP:0001944) | 2.92554963 |
| 45 | Abnormality of vitamin B metabolism (HP:0004340) | 2.92394908 |
| 46 | Hyperglycinuria (HP:0003108) | 2.89022760 |
| 47 | Increased purine levels (HP:0004368) | 2.86650729 |
| 48 | Hyperuricemia (HP:0002149) | 2.86650729 |
| 49 | Palpitations (HP:0001962) | 2.85963962 |
| 50 | Intrahepatic cholestasis (HP:0001406) | 2.85330168 |
| 51 | Abnormality of macrophages (HP:0004311) | 2.83371655 |
| 52 | Complement deficiency (HP:0004431) | 2.82268655 |
| 53 | Abnormal biliary tract morphology (HP:0012440) | 2.79265731 |
| 54 | Abnormality of complement system (HP:0005339) | 2.72711521 |
| 55 | Xanthomatosis (HP:0000991) | 2.67148190 |
| 56 | Periodontitis (HP:0000704) | 2.65993842 |
| 57 | Micronodular cirrhosis (HP:0001413) | 2.65896019 |
| 58 | Abnormal tarsal ossification (HP:0008369) | 2.63270083 |
| 59 | Hyperphosphaturia (HP:0003109) | 2.60291355 |
| 60 | Hypercholesterolemia (HP:0003124) | 2.59482472 |
| 61 | Nephrolithiasis (HP:0000787) | 2.58218867 |
| 62 | Pancreatitis (HP:0001733) | 2.58180676 |
| 63 | Abnormality of the level of lipoprotein cholesterol (HP:0010979) | 2.57463739 |
| 64 | Pustule (HP:0200039) | 2.54570300 |
| 65 | Hyperglycinemia (HP:0002154) | 2.53666259 |
| 66 | Severe combined immunodeficiency (HP:0004430) | 2.51651390 |
| 67 | Increased mean platelet volume (HP:0011877) | 2.50613454 |
| 68 | Alkalosis (HP:0001948) | 2.50182440 |
| 69 | Rectal prolapse (HP:0002035) | 2.49952906 |
| 70 | Abnormality of vitamin metabolism (HP:0100508) | 2.49650213 |
| 71 | Prolonged QT interval (HP:0001657) | 2.45339789 |
| 72 | Decreased circulating renin level (HP:0003351) | 2.44039373 |
| 73 | Abnormal urine phosphate concentration (HP:0012599) | 2.43220712 |
| 74 | Mesangial abnormality (HP:0001966) | 2.41732418 |
| 75 | Nausea (HP:0002018) | 2.41535652 |
| 76 | Nephritis (HP:0000123) | 2.40494353 |
| 77 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.40331579 |
| 78 | Reticulocytosis (HP:0001923) | 2.37028526 |
| 79 | Metabolic alkalosis (HP:0200114) | 2.34383367 |
| 80 | Combined immunodeficiency (HP:0005387) | 2.32970708 |
| 81 | Increased IgE level (HP:0003212) | 2.28958352 |
| 82 | Tetany (HP:0001281) | 2.28521710 |
| 83 | Wide cranial sutures (HP:0010537) | 2.27618225 |
| 84 | Confusion (HP:0001289) | 2.27289728 |
| 85 | Premature loss of primary teeth (HP:0006323) | 2.26817856 |
| 86 | Abnormality of purine metabolism (HP:0004352) | 2.25187502 |
| 87 | Abnormality of the gastric mucosa (HP:0004295) | 2.24228774 |
| 88 | Posterior subcapsular cataract (HP:0007787) | 2.23047675 |
| 89 | Abnormal platelet volume (HP:0011876) | 2.22379803 |
| 90 | Hyperbilirubinemia (HP:0002904) | 2.21780547 |
| 91 | Pili torti (HP:0003777) | 2.20650645 |
| 92 | Delayed CNS myelination (HP:0002188) | 2.15659169 |
| 93 | Mildly elevated creatine phosphokinase (HP:0008180) | 2.15538537 |
| 94 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 2.14570008 |
| 95 | Gout (HP:0001997) | 2.13731660 |
| 96 | Polycythemia (HP:0001901) | 2.11890799 |
| 97 | Abnormality of chloride homeostasis (HP:0011422) | 2.09310075 |
| 98 | Myopathic facies (HP:0002058) | 2.08097049 |
| 99 | Steatorrhea (HP:0002570) | 2.07805262 |
| 100 | Hypomagnesemia (HP:0002917) | 2.07724612 |
| 101 | Late onset (HP:0003584) | 2.07453161 |
| 102 | Hyperparathyroidism (HP:0000843) | 2.05442625 |
| 103 | Biliary tract neoplasm (HP:0100574) | 2.04301211 |
| 104 | Hypoalbuminemia (HP:0003073) | 2.02448231 |
| 105 | Abnormal albumin level (HP:0012116) | 2.02448231 |
| 106 | Amyloidosis (HP:0011034) | 2.01723640 |
| 107 | Abnormality of the 1st metacarpal (HP:0010009) | 2.01152941 |
| 108 | Cholecystitis (HP:0001082) | 2.00693606 |
| 109 | Abnormal gallbladder physiology (HP:0012438) | 2.00693606 |
| 110 | Male infertility (HP:0003251) | 1.99808379 |
| 111 | Abnormality of glycine metabolism (HP:0010895) | 1.99654977 |
| 112 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.99654977 |
| 113 | Cheilitis (HP:0100825) | 1.99180037 |
| 114 | Proximal tubulopathy (HP:0000114) | 1.97298268 |
| 115 | Gingival bleeding (HP:0000225) | 1.96517378 |
| 116 | Epidermoid cyst (HP:0200040) | 1.96478413 |
| 117 | Goiter (HP:0000853) | 1.96310794 |
| 118 | Hypotension (HP:0002615) | 1.95114906 |
| 119 | Hyperammonemia (HP:0001987) | 1.94584287 |
| 120 | Eczematoid dermatitis (HP:0000976) | 1.94475135 |
| 121 | Fragile skin (HP:0001030) | 1.92628926 |
| 122 | Neoplasm of the rectum (HP:0100743) | 1.91195961 |
| 123 | Chronic otitis media (HP:0000389) | 1.90090199 |
| 124 | Ventricular arrhythmia (HP:0004308) | 1.89079247 |
| 125 | Abnormality of renal excretion (HP:0011036) | 1.88781834 |
| 126 | Abnormal glucose tolerance (HP:0001952) | 1.88539273 |
| 127 | Abnormality of carpal bone ossification (HP:0006257) | 1.87204550 |
| 128 | Bundle branch block (HP:0011710) | 1.87101940 |
| 129 | Protuberant abdomen (HP:0001538) | 1.86907377 |
| 130 | Dysostosis multiplex (HP:0000943) | 1.84756764 |
| 131 | Thin bony cortex (HP:0002753) | 1.83751879 |
| 132 | Hemorrhage of the eye (HP:0011885) | 1.83095034 |
| 133 | Fragile nails (HP:0001808) | 1.82054901 |
| 134 | Hypophosphatemia (HP:0002148) | 1.81190404 |
| 135 | Metabolic acidosis (HP:0001942) | 1.81152043 |
| 136 | Abnormality of renin-angiotensin system (HP:0000847) | 1.80476271 |
| 137 | Progressive sensorineural hearing impairment (HP:0000408) | 1.80244966 |
| 138 | Mitral stenosis (HP:0001718) | 1.76551849 |
| 139 | Subcapsular cataract (HP:0000523) | 1.74637487 |
| 140 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.71985773 |
| 141 | Dicarboxylic aciduria (HP:0003215) | 1.71985773 |
| 142 | Peripheral demyelination (HP:0011096) | 1.70832059 |
| 143 | Hyperactive renin-angiotensin system (HP:0000841) | 1.68188821 |
| 144 | Abnormality of transition element cation homeostasis (HP:0011030) | 1.65329748 |
| 145 | Ulnar claw (HP:0001178) | 1.64381853 |
| 146 | Stomach cancer (HP:0012126) | 1.64154062 |
| 147 | Severe visual impairment (HP:0001141) | 1.64093738 |
| 148 | Renal tubular acidosis (HP:0001947) | 1.61925404 |
| 149 | Hypocalcemia (HP:0002901) | 1.61820837 |
| 150 | Segmental peripheral demyelination/remyelination (HP:0003481) | 1.60830590 |
| 151 | Loss of speech (HP:0002371) | 1.60388780 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | PIK3CG | 7.66488809 |
| 2 | LMTK2 | 6.86614533 |
| 3 | MUSK | 6.40954776 |
| 4 | ACVR1B | 6.14734127 |
| 5 | FRK | 4.58731016 |
| 6 | MST4 | 4.26978146 |
| 7 | PRKG2 | 4.05642426 |
| 8 | MST1R | 3.74654718 |
| 9 | RIPK1 | 3.54971997 |
| 10 | NME1 | 3.25939007 |
| 11 | GRK6 | 3.24163923 |
| 12 | PBK | 2.70151516 |
| 13 | MAP2K2 | 2.59906027 |
| 14 | MAP3K2 | 2.56077703 |
| 15 | EPHB2 | 2.44367609 |
| 16 | FGFR4 | 2.17122877 |
| 17 | MAP3K10 | 2.16152104 |
| 18 | NUAK1 | 2.02351893 |
| 19 | TTK | 1.86417681 |
| 20 | EPHA3 | 1.83350082 |
| 21 | AKT3 | 1.79581172 |
| 22 | PTK6 | 1.77150409 |
| 23 | PIK3CA | 1.65940440 |
| 24 | TESK1 | 1.63128437 |
| 25 | EPHA2 | 1.60365590 |
| 26 | MAP3K12 | 1.49355963 |
| 27 | MAP2K6 | 1.49295078 |
| 28 | MAP3K11 | 1.41481375 |
| 29 | ERN1 | 1.37360224 |
| 30 | TAOK1 | 1.34430678 |
| 31 | MYLK | 1.34355842 |
| 32 | TYK2 | 1.33666866 |
| 33 | KSR2 | 1.24470603 |
| 34 | ADRBK2 | 1.22063658 |
| 35 | STK24 | 1.18449902 |
| 36 | TESK2 | 1.17168440 |
| 37 | SCYL2 | 1.16721203 |
| 38 | BLK | 1.14172193 |
| 39 | NLK | 1.11442077 |
| 40 | BCKDK | 1.11431623 |
| 41 | MET | 1.10600242 |
| 42 | MAP3K8 | 1.03993682 |
| 43 | FGFR3 | 0.95449824 |
| 44 | IRAK3 | 0.92476237 |
| 45 | PRKCI | 0.91403743 |
| 46 | BMX | 0.84888610 |
| 47 | CDC42BPA | 0.84583431 |
| 48 | PTK2 | 0.84496312 |
| 49 | STK10 | 0.84371648 |
| 50 | ERBB2 | 0.83992176 |
| 51 | RIPK4 | 0.83837349 |
| 52 | MATK | 0.79717130 |
| 53 | FGFR2 | 0.78204998 |
| 54 | STK39 | 0.76145098 |
| 55 | DDR2 | 0.75245719 |
| 56 | MAP2K1 | 0.75198657 |
| 57 | EPHA4 | 0.74874387 |
| 58 | PRKAA2 | 0.73928538 |
| 59 | CASK | 0.73339512 |
| 60 | LIMK1 | 0.72340424 |
| 61 | JAK1 | 0.70103726 |
| 62 | EPHB1 | 0.68720388 |
| 63 | IRAK1 | 0.65082218 |
| 64 | ABL2 | 0.64512877 |
| 65 | FER | 0.59161703 |
| 66 | TBK1 | 0.58821610 |
| 67 | CAMK2D | 0.57892963 |
| 68 | MAP3K1 | 0.57401492 |
| 69 | MELK | 0.56285942 |
| 70 | IKBKE | 0.55770060 |
| 71 | MAPK11 | 0.53896514 |
| 72 | PAK4 | 0.53824966 |
| 73 | PKN2 | 0.52139151 |
| 74 | JAK3 | 0.52120191 |
| 75 | KIT | 0.50997369 |
| 76 | LATS1 | 0.50766270 |
| 77 | WNK3 | 0.50216452 |
| 78 | MAP4K1 | 0.48579069 |
| 79 | BRSK2 | 0.48336151 |
| 80 | ALK | 0.46898329 |
| 81 | PRKAA1 | 0.46777269 |
| 82 | PDPK1 | 0.46713695 |
| 83 | ZAP70 | 0.46381379 |
| 84 | NTRK3 | 0.44561367 |
| 85 | CAMK2G | 0.44527241 |
| 86 | MAP3K7 | 0.42274990 |
| 87 | PAK1 | 0.41689036 |
| 88 | STK3 | 0.40988391 |
| 89 | TAOK3 | 0.39154992 |
| 90 | CSK | 0.38394487 |
| 91 | CSF1R | 0.38101787 |
| 92 | OXSR1 | 0.37257118 |
| 93 | AURKB | 0.37195007 |
| 94 | MAPKAPK2 | 0.37105334 |
| 95 | CAMK2B | 0.37090010 |
| 96 | IRAK2 | 0.36967721 |
| 97 | SRC | 0.36284985 |
| 98 | PRKCA | 0.36046028 |
| 99 | ERBB4 | 0.35411188 |
| 100 | KDR | 0.34121459 |
| 101 | FGR | 0.33444666 |
| 102 | LRRK2 | 0.32364975 |
| 103 | MAP3K3 | 0.31925961 |
| 104 | NEK6 | 0.31362217 |
| 105 | CSNK1A1 | 0.31303257 |
| 106 | JAK2 | 0.31005941 |
| 107 | STK11 | 0.30942974 |
| 108 | TXK | 0.30747306 |
| 109 | PIM2 | 0.30547829 |
| 110 | ITK | 0.30345127 |
| 111 | STK4 | 0.28551752 |
| 112 | PRKCD | 0.27616487 |
| 113 | PRKCQ | 0.27561764 |
| 114 | PDGFRA | 0.27527029 |
| 115 | CDK19 | 0.27267489 |
| 116 | IRAK4 | 0.27208442 |
| 117 | ROCK1 | 0.26777387 |
| 118 | CDK6 | 0.26156875 |
| 119 | DAPK2 | 0.26129230 |
| 120 | MAP3K9 | 0.26004297 |
| 121 | INSRR | 0.25994878 |
| 122 | PDK1 | 0.25780735 |
| 123 | PRKCE | 0.25406538 |
| 124 | PRKACG | 0.25401898 |
| 125 | GSK3A | 0.25070577 |
| 126 | RET | 0.24978291 |
| 127 | MAPKAPK3 | 0.24795333 |
| 128 | EIF2AK1 | 0.23985241 |
| 129 | GRK1 | 0.23501719 |
| 130 | TNIK | 0.23257456 |
| 131 | LCK | 0.21570433 |
| 132 | IGF1R | 0.19111827 |
| 133 | DMPK | 0.18145097 |
| 134 | PAK2 | 0.17410042 |
| 135 | ICK | 0.17320165 |
| 136 | GRK5 | 0.16501261 |
| 137 | EEF2K | 0.16299076 |
| 138 | WNK4 | 0.16160219 |
| 139 | PAK3 | 0.15960197 |
| 140 | CSNK1E | 0.15809505 |
| 141 | PRKCZ | 0.15515732 |
| 142 | RPS6KA1 | 0.14718617 |
| 143 | PDK2 | 0.14606502 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Fat digestion and absorption_Homo sapiens_hsa04975 | 6.03025847 |
| 2 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 4.84694318 |
| 3 | Renin-angiotensin system_Homo sapiens_hsa04614 | 4.14862757 |
| 4 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 3.65329318 |
| 5 | Mineral absorption_Homo sapiens_hsa04978 | 3.50256321 |
| 6 | Sulfur metabolism_Homo sapiens_hsa00920 | 2.71374906 |
| 7 | Galactose metabolism_Homo sapiens_hsa00052 | 2.67965776 |
| 8 | Folate biosynthesis_Homo sapiens_hsa00790 | 2.48957752 |
| 9 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 2.47061528 |
| 10 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 2.42897452 |
| 11 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 2.38293207 |
| 12 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 2.33722977 |
| 13 | Caffeine metabolism_Homo sapiens_hsa00232 | 2.32046680 |
| 14 | Histidine metabolism_Homo sapiens_hsa00340 | 2.29517933 |
| 15 | Protein digestion and absorption_Homo sapiens_hsa04974 | 2.24692597 |
| 16 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 2.18827883 |
| 17 | Bile secretion_Homo sapiens_hsa04976 | 2.06043854 |
| 18 | Asthma_Homo sapiens_hsa05310 | 1.79406221 |
| 19 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.69015423 |
| 20 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 1.55666566 |
| 21 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.52910228 |
| 22 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.49940723 |
| 23 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.46889377 |
| 24 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.44942071 |
| 25 | Arginine biosynthesis_Homo sapiens_hsa00220 | 1.37419429 |
| 26 | Fatty acid degradation_Homo sapiens_hsa00071 | 1.34963541 |
| 27 | Allograft rejection_Homo sapiens_hsa05330 | 1.29812575 |
| 28 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 1.29468216 |
| 29 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 1.29183525 |
| 30 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.28085808 |
| 31 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 1.24982760 |
| 32 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.24759834 |
| 33 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.22883549 |
| 34 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.22402262 |
| 35 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.21156245 |
| 36 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.21082219 |
| 37 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.15760201 |
| 38 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.13915038 |
| 39 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.13764964 |
| 40 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 1.09975862 |
| 41 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 1.07003059 |
| 42 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.00395611 |
| 43 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.97682657 |
| 44 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.97430298 |
| 45 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.94402905 |
| 46 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.93569293 |
| 47 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.92846577 |
| 48 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.84668221 |
| 49 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.83449613 |
| 50 | Other glycan degradation_Homo sapiens_hsa00511 | 0.83171037 |
| 51 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.79832126 |
| 52 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.75633333 |
| 53 | ABC transporters_Homo sapiens_hsa02010 | 0.74197325 |
| 54 | Carbon metabolism_Homo sapiens_hsa01200 | 0.73354173 |
| 55 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.68405981 |
| 56 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.65722212 |
| 57 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.64887658 |
| 58 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.63144654 |
| 59 | Retinol metabolism_Homo sapiens_hsa00830 | 0.61327766 |
| 60 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.60704142 |
| 61 | Tight junction_Homo sapiens_hsa04530 | 0.59841255 |
| 62 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.57724926 |
| 63 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.56256750 |
| 64 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.55849227 |
| 65 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.54361556 |
| 66 | Alzheimers disease_Homo sapiens_hsa05010 | 0.52915090 |
| 67 | Leishmaniasis_Homo sapiens_hsa05140 | 0.52441453 |
| 68 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.51480933 |
| 69 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.49135131 |
| 70 | Parkinsons disease_Homo sapiens_hsa05012 | 0.47921157 |
| 71 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.47810121 |
| 72 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.45875207 |
| 73 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.41896207 |
| 74 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.41151597 |
| 75 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.40998638 |
| 76 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.39975581 |
| 77 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.39082728 |
| 78 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.38654143 |
| 79 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.38607092 |
| 80 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.38596306 |
| 81 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.38310468 |
| 82 | Renin secretion_Homo sapiens_hsa04924 | 0.37142473 |
| 83 | Hepatitis C_Homo sapiens_hsa05160 | 0.36917887 |
| 84 | Metabolic pathways_Homo sapiens_hsa01100 | 0.35553306 |
| 85 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.31678414 |
| 86 | Viral myocarditis_Homo sapiens_hsa05416 | 0.30880478 |
| 87 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.30765496 |
| 88 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.30657685 |
| 89 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.30533795 |
| 90 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.29966708 |
| 91 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.28756714 |
| 92 | Salmonella infection_Homo sapiens_hsa05132 | 0.28527101 |
| 93 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.26954138 |
| 94 | Bladder cancer_Homo sapiens_hsa05219 | 0.26901807 |
| 95 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.26348886 |
| 96 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.25721715 |
| 97 | Insulin resistance_Homo sapiens_hsa04931 | 0.25338727 |
| 98 | Thyroid cancer_Homo sapiens_hsa05216 | 0.22594994 |
| 99 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.22006240 |
| 100 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.21977166 |
| 101 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.20062892 |
| 102 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.20044020 |
| 103 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.19627271 |
| 104 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.18490929 |
| 105 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.18339636 |
| 106 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.17857121 |
| 107 | Huntingtons disease_Homo sapiens_hsa05016 | 0.17458179 |
| 108 | Peroxisome_Homo sapiens_hsa04146 | 0.17089591 |
| 109 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.16987622 |
| 110 | Cocaine addiction_Homo sapiens_hsa05030 | 0.16613347 |
| 111 | Pertussis_Homo sapiens_hsa05133 | 0.16431903 |
| 112 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.16183156 |
| 113 | Sulfur relay system_Homo sapiens_hsa04122 | 0.15602134 |
| 114 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.15546570 |
| 115 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.14887454 |
| 116 | Legionellosis_Homo sapiens_hsa05134 | 0.14639237 |
| 117 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.14516205 |
| 118 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.11156570 |
| 119 | Lysine degradation_Homo sapiens_hsa00310 | 0.10516311 |
| 120 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.09317866 |
| 121 | Insulin secretion_Homo sapiens_hsa04911 | 0.08316943 |
| 122 | Salivary secretion_Homo sapiens_hsa04970 | 0.07761210 |
| 123 | Tuberculosis_Homo sapiens_hsa05152 | 0.07075990 |
| 124 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.07062997 |
| 125 | Adherens junction_Homo sapiens_hsa04520 | 0.06738877 |
| 126 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.06208914 |
| 127 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.06019963 |
| 128 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.05561213 |
| 129 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.05132542 |
| 130 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.03858813 |

