MS4A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript variants have been described but require experimental validation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* positive regulation of mast cell activation involved in immune response (GO:0033008)9.08585583
2* positive regulation of mast cell degranulation (GO:0043306)9.08585583
3positive regulation of megakaryocyte differentiation (GO:0045654)8.53801175
4positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)7.74249375
5fucose catabolic process (GO:0019317)7.67442864
6L-fucose metabolic process (GO:0042354)7.67442864
7L-fucose catabolic process (GO:0042355)7.67442864
8* positive regulation of mast cell activation (GO:0033005)7.63275665
9* positive regulation of myeloid leukocyte mediated immunity (GO:0002888)7.02577184
10regulation of acute inflammatory response to antigenic stimulus (GO:0002864)6.81628392
11positive regulation of inflammatory response to antigenic stimulus (GO:0002863)6.30689493
12* positive regulation of leukocyte degranulation (GO:0043302)6.19758095
13production of molecular mediator involved in inflammatory response (GO:0002532)6.09195736
14* regulation of mast cell degranulation (GO:0043304)6.07368438
15leukotriene biosynthetic process (GO:0019370)5.96415298
16behavioral response to nicotine (GO:0035095)5.66603367
17* regulation of mast cell activation involved in immune response (GO:0033006)5.63173808
18positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)5.48289286
19definitive hemopoiesis (GO:0060216)5.37094021
20* regulation of mast cell activation (GO:0033003)5.18361122
21monoamine transport (GO:0015844)5.11980408
22mast cell degranulation (GO:0043303)4.83964206
23mast cell activation involved in immune response (GO:0002279)4.83964206
24sulfation (GO:0051923)4.70521500
25regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)4.65828282
26mast cell activation (GO:0045576)4.52722809
27* regulation of myeloid leukocyte mediated immunity (GO:0002886)4.52222082
28actin nucleation (GO:0045010)4.37082811
29tachykinin receptor signaling pathway (GO:0007217)4.32287501
30imidazole-containing compound metabolic process (GO:0052803)4.29482735
31* regulation of leukocyte degranulation (GO:0043300)4.24694796
32thrombin receptor signaling pathway (GO:0070493)4.24359496
33response to pheromone (GO:0019236)4.18478037
34negative regulation of mast cell activation (GO:0033004)4.18060155
35DNA topological change (GO:0006265)4.17518814
36* positive regulation of regulated secretory pathway (GO:1903307)4.15705076
37DNA deamination (GO:0045006)4.02072180
38positive regulation of B cell differentiation (GO:0045579)3.95894182
39Arp2/3 complex-mediated actin nucleation (GO:0034314)3.91826374
40indolalkylamine metabolic process (GO:0006586)3.89122387
41leukotriene metabolic process (GO:0006691)3.88080929
42heparin biosynthetic process (GO:0030210)3.87967759
43heparin metabolic process (GO:0030202)3.87967759
44positive regulation of chemokine secretion (GO:0090197)3.87279509
45ribosomal small subunit assembly (GO:0000028)3.79947290
46fucosylation (GO:0036065)3.78400697
47regulation of inflammatory response to antigenic stimulus (GO:0002861)3.77483557
48toxin transport (GO:1901998)3.74593857
49negative regulation of phagocytosis (GO:0050765)3.73000685
50tyrosine phosphorylation of STAT protein (GO:0007260)3.68185865
51respiratory burst (GO:0045730)3.68045277
52cytokine biosynthetic process (GO:0042089)3.67081379
53flavonoid metabolic process (GO:0009812)3.65382778
54antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.64772500
55antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.64772500
56peptide hormone processing (GO:0016486)3.64320525
57histamine transport (GO:0051608)3.63707062
58regulation of megakaryocyte differentiation (GO:0045652)3.62878988
59regulation of erythrocyte differentiation (GO:0045646)3.61583799
60negative regulation of telomerase activity (GO:0051974)3.60162744
61cytokine production involved in immune response (GO:0002367)3.57814418
62detection of light stimulus involved in sensory perception (GO:0050962)3.56719077
63detection of light stimulus involved in visual perception (GO:0050908)3.56719077
64fucose metabolic process (GO:0006004)3.49456680
65indole-containing compound catabolic process (GO:0042436)3.47688451
66indolalkylamine catabolic process (GO:0046218)3.47688451
67tryptophan catabolic process (GO:0006569)3.47688451
68positive regulation of B cell mediated immunity (GO:0002714)3.46008379
69positive regulation of immunoglobulin mediated immune response (GO:0002891)3.46008379
70positive regulation of digestive system process (GO:0060456)3.45545306
71* regulation of regulated secretory pathway (GO:1903305)3.43686837
72viral transcription (GO:0019083)3.42631264
73cellular response to exogenous dsRNA (GO:0071360)3.40564914
74hepatocyte differentiation (GO:0070365)3.40185867
75B cell receptor signaling pathway (GO:0050853)3.37092134
76replication fork processing (GO:0031297)3.33484484
77positive regulation of erythrocyte differentiation (GO:0045648)3.32781722
78cytokine metabolic process (GO:0042107)3.32529051
79mitochondrial respiratory chain complex I assembly (GO:0032981)3.29447918
80NADH dehydrogenase complex assembly (GO:0010257)3.29447918
81mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.29447918
82cell proliferation in forebrain (GO:0021846)3.28837216
83kynurenine metabolic process (GO:0070189)3.27764327
84tryptophan metabolic process (GO:0006568)3.27449947
85negative regulation of bone mineralization (GO:0030502)3.26685459
86catecholamine transport (GO:0051937)3.24344216
87secretory granule organization (GO:0033363)3.19698597
88cotranslational protein targeting to membrane (GO:0006613)3.18255778
89negative regulation of systemic arterial blood pressure (GO:0003085)3.17229292
90regulation of T cell tolerance induction (GO:0002664)3.16862694
91translational termination (GO:0006415)3.15053031
92regulation of glucokinase activity (GO:0033131)3.13766514
93regulation of hexokinase activity (GO:1903299)3.13766514
94positive regulation of acute inflammatory response (GO:0002675)3.12776165
95megakaryocyte development (GO:0035855)3.12599164
96detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.12225392
97regulation of telomere maintenance via telomerase (GO:0032210)3.11947230
98SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.11781293
99positive regulation of defense response to virus by host (GO:0002230)3.10964090
100signal peptide processing (GO:0006465)3.10289871
101regulation of germinal center formation (GO:0002634)3.09036586
102protein localization to chromosome, centromeric region (GO:0071459)3.08056136
103catecholamine biosynthetic process (GO:0042423)3.07716627
104catechol-containing compound biosynthetic process (GO:0009713)3.07716627
105primary amino compound metabolic process (GO:1901160)3.05851875
106cellular response to ATP (GO:0071318)3.04782872
107CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.04710256
108granulocyte differentiation (GO:0030851)3.04673615
109protein targeting to ER (GO:0045047)3.04250809
110lipoxygenase pathway (GO:0019372)3.03667778
111indole-containing compound metabolic process (GO:0042430)3.00625196
112germ cell migration (GO:0008354)2.97423532
113lymphoid progenitor cell differentiation (GO:0002320)2.97305883
114rRNA catabolic process (GO:0016075)2.96479828
115protein localization to kinetochore (GO:0034501)2.96395334
116mitotic sister chromatid segregation (GO:0000070)2.96017516
117positive regulation of fatty acid oxidation (GO:0046321)2.93877943
118cytidine deamination (GO:0009972)2.93233097
119cytidine metabolic process (GO:0046087)2.93233097
120cytidine catabolic process (GO:0006216)2.93233097
121regulation of T cell cytokine production (GO:0002724)2.93038870
122platelet dense granule organization (GO:0060155)2.92719236
1233-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.91490383
124purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.91490383
125establishment of protein localization to endoplasmic reticulum (GO:0072599)2.90458502
126protein complex biogenesis (GO:0070271)2.89829852
127T cell homeostasis (GO:0043029)2.89171092
128antigen processing and presentation of endogenous antigen (GO:0019883)2.88166249
129negative regulation of multicellular organism growth (GO:0040015)2.87475278
130neutrophil mediated immunity (GO:0002446)2.87290373
131regulation of B cell mediated immunity (GO:0002712)2.86627483
132protein localization to endoplasmic reticulum (GO:0070972)2.86616122
133water-soluble vitamin biosynthetic process (GO:0042364)2.85946006
134positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.85745500
135amine biosynthetic process (GO:0009309)2.85062864
136cellular biogenic amine biosynthetic process (GO:0042401)2.85062864
137defense response to fungus (GO:0050832)2.82358763
138serotonin metabolic process (GO:0042428)2.81487847
139negative regulation of macrophage differentiation (GO:0045650)2.80183898
140translational elongation (GO:0006414)2.79559426
141positive regulation of gamma-delta T cell activation (GO:0046645)2.79186094
142positive regulation of granulocyte differentiation (GO:0030854)2.77968345
143protein polyglutamylation (GO:0018095)2.77891268
144piRNA metabolic process (GO:0034587)2.74873916
145cellular response to zinc ion (GO:0071294)2.73583216
146regulation of rhodopsin mediated signaling pathway (GO:0022400)2.73258486
147leukocyte degranulation (GO:0043299)2.72236740
148NAD biosynthetic process (GO:0009435)2.71435953
149positive regulation of oligodendrocyte differentiation (GO:0048714)2.71402301
150somite development (GO:0061053)2.71163841
151regulation of tolerance induction (GO:0002643)2.69277606
152adaptation of signaling pathway (GO:0023058)2.64628097
153negative regulation of transcription regulatory region DNA binding (GO:2000678)2.62511502
154membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.59260706
155regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.59004406
156rhodopsin mediated signaling pathway (GO:0016056)2.58409556
157mitochondrial respiratory chain complex assembly (GO:0033108)2.58076272
158axoneme assembly (GO:0035082)2.56968341
159DNA methylation involved in gamete generation (GO:0043046)2.56623697
160regulation of glomerulus development (GO:0090192)2.55598153
161neuronal action potential (GO:0019228)2.55056622
162positive regulation of fatty acid transport (GO:2000193)2.51482542
163regulation of sequestering of triglyceride (GO:0010889)2.50899934
164phosphatidylinositol acyl-chain remodeling (GO:0036149)2.48088915
165positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.46292123
166preassembly of GPI anchor in ER membrane (GO:0016254)2.45912882
167regulation of mesoderm development (GO:2000380)2.45204476
168cornea development in camera-type eye (GO:0061303)2.44221495
169gamma-aminobutyric acid transport (GO:0015812)2.42460651
170positive regulation of cAMP-mediated signaling (GO:0043950)2.42117294
171pyrimidine ribonucleoside catabolic process (GO:0046133)2.41062894
172mannosylation (GO:0097502)2.39932175
173regulation of hippo signaling (GO:0035330)2.36163302
174regulation of triglyceride catabolic process (GO:0010896)2.35911867
175regulation of action potential (GO:0098900)2.35299820
176epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.35194780
177regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.32626989
178reflex (GO:0060004)2.32556456
179negative regulation of telomere maintenance (GO:0032205)2.31161499
180negative regulation of cytosolic calcium ion concentration (GO:0051481)2.29675819
181drug catabolic process (GO:0042737)2.29449317
182negative regulation of T-helper cell differentiation (GO:0045623)2.28562743
183negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.28562743
184amine catabolic process (GO:0009310)2.27818797
185cellular biogenic amine catabolic process (GO:0042402)2.27818797
186protein-cofactor linkage (GO:0018065)2.27002446
187regulation of meiosis I (GO:0060631)2.26482548
188multicellular organism reproduction (GO:0032504)2.25120453
189cellular ketone body metabolic process (GO:0046950)2.24408446
190regulation of collateral sprouting (GO:0048670)2.24376475
191kidney morphogenesis (GO:0060993)2.23722623
192benzene-containing compound metabolic process (GO:0042537)2.22911778
193angiotensin maturation (GO:0002003)11.4952442
194regulation of hypersensitivity (GO:0002883)10.1306431

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human9.82726481
2SCL_19346495_ChIP-Seq_HPC-7_Human4.72673170
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.70066714
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.65539710
5E2F7_22180533_ChIP-Seq_HELA_Human4.49621604
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.97840043
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.95926355
8MYB_21317192_ChIP-Seq_ERMYB_Mouse3.89289957
9GATA1_22025678_ChIP-Seq_K562_Human3.71223597
10EZH2_22144423_ChIP-Seq_EOC_Human3.47483759
11ZNF274_21170338_ChIP-Seq_K562_Hela3.28565755
12RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.07832727
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.03377734
14SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.98229975
15VDR_22108803_ChIP-Seq_LS180_Human2.88715754
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.72273804
17VDR_21846776_ChIP-Seq_THP-1_Human2.67796264
18* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.51958030
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.41894304
20RUNX1_22412390_ChIP-Seq_EML_Mouse2.39440153
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.39059599
22GBX2_23144817_ChIP-Seq_PC3_Human2.36642027
23VDR_24763502_ChIP-Seq_THP-1_Human2.36036703
24RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.28931906
25E2F4_17652178_ChIP-ChIP_JURKAT_Human2.23185003
26SPI1_23547873_ChIP-Seq_NB4_Human2.22105577
27FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.20838483
28GATA1_22383799_ChIP-Seq_G1ME_Mouse2.19762391
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.16457767
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.12011920
31* HOXB4_20404135_ChIP-ChIP_EML_Mouse2.00627634
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.00073002
33BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.96955471
34MYB_26560356_Chip-Seq_TH2_Human1.96567821
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.95972271
36STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.95968690
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.95833957
38LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.94358054
39* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.93723954
40GATA1_19941827_ChIP-Seq_MEL_Mouse1.92121131
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.92108225
42MYC_18555785_ChIP-Seq_MESCs_Mouse1.87770301
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.86502911
44ER_23166858_ChIP-Seq_MCF-7_Human1.86329457
45TCF7_22412390_ChIP-Seq_EML_Mouse1.84544133
46STAT4_19710469_ChIP-ChIP_TH1__Mouse1.83839662
47MYC_22102868_ChIP-Seq_BL_Human1.83631394
48FUS_26573619_Chip-Seq_HEK293_Human1.83175881
49TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.82411734
50IGF1R_20145208_ChIP-Seq_DFB_Human1.81612869
51NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.80663305
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79003076
53SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.77830990
54EWS_26573619_Chip-Seq_HEK293_Human1.77236754
55P300_19829295_ChIP-Seq_ESCs_Human1.75688101
56NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.75634151
57CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.72447328
58* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68899303
59UTX_26944678_Chip-Seq_JUKART_Human1.68837235
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.66490609
61BCAT_22108803_ChIP-Seq_LS180_Human1.66268233
62* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.65484733
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.65236160
64NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.63266859
65STAT6_21828071_ChIP-Seq_BEAS2B_Human1.60785781
66MYB_26560356_Chip-Seq_TH1_Human1.58761194
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.57912627
68GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.57132311
69IRF1_19129219_ChIP-ChIP_H3396_Human1.55758701
70STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.55084611
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.50398086
72IRF8_22096565_ChIP-ChIP_GC-B_Human1.49011687
73MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.48832930
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.47864040
75RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.47405783
76IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.46483042
77IRF8_27001747_Chip-Seq_BMDM_Mouse1.43667470
78NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.43302142
79STAT3_23295773_ChIP-Seq_U87_Human1.40884779
80PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40493820
81IRF8_21731497_ChIP-ChIP_J774_Mouse1.39793779
82TAF15_26573619_Chip-Seq_HEK293_Human1.39774075
83MAF_26560356_Chip-Seq_TH1_Human1.39664229
84SPI1_23127762_ChIP-Seq_K562_Human1.39585195
85PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.38201739
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36756229
87ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36027542
88PCGF2_27294783_Chip-Seq_ESCs_Mouse1.35539240
89HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.35264706
90TCF4_23295773_ChIP-Seq_U87_Human1.35135011
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34669049
92ERG_20887958_ChIP-Seq_HPC-7_Mouse1.34574080
93POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33590352
94TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33590352
95IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.33059376
96TP53_22573176_ChIP-Seq_HFKS_Human1.32767437
97RUNX_20019798_ChIP-Seq_JUKART_Human1.31539922
98IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31537559
99CBP_20019798_ChIP-Seq_JUKART_Human1.31537559
100GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.30839451
101SOX2_19829295_ChIP-Seq_ESCs_Human1.29879849
102NANOG_19829295_ChIP-Seq_ESCs_Human1.29879849
103SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27925616
104PRDM14_20953172_ChIP-Seq_ESCs_Human1.27766821
105FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.27281804
106PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26886307
107* AUTS2_25519132_ChIP-Seq_293T-REX_Human1.26768213
108SMAD4_21799915_ChIP-Seq_A2780_Human1.26478171
109GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26175608
110FOXA1_27270436_Chip-Seq_PROSTATE_Human1.25912234
111FOXA1_25329375_ChIP-Seq_VCAP_Human1.25912234
112CBX2_27304074_Chip-Seq_ESCs_Mouse1.25026209
113MYC_18940864_ChIP-ChIP_HL60_Human1.24918126
114AR_25329375_ChIP-Seq_VCAP_Human1.24610324
115XRN2_22483619_ChIP-Seq_HELA_Human1.24289707
116SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23284269
117E2F1_21310950_ChIP-Seq_MCF-7_Human1.23236018
118PIAS1_25552417_ChIP-Seq_VCAP_Human1.23218085
119EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.21823996
120GATA3_21878914_ChIP-Seq_MCF-7_Human1.21719339
121MYC_19079543_ChIP-ChIP_MESCs_Mouse1.20918039
122TCF4_22108803_ChIP-Seq_LS180_Human1.20040430
123EGR1_23403033_ChIP-Seq_LIVER_Mouse1.19570509
124TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18843782
125BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18624230
126NCOR_22424771_ChIP-Seq_293T_Human1.18131909
127REST_21632747_ChIP-Seq_MESCs_Mouse1.17644562
128SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17372386
129FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.15596601
130ETV2_25802403_ChIP-Seq_MESCs_Mouse1.14491243
131NFE2_27457419_Chip-Seq_LIVER_Mouse1.13833493
132SMAD3_21741376_ChIP-Seq_EPCs_Human1.12979666
133PU_27001747_Chip-Seq_BMDM_Mouse1.11563563
134SMAD4_21741376_ChIP-Seq_EPCs_Human1.10759582
135MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09095836
136* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09037268
137FLI1_21867929_ChIP-Seq_TH2_Mouse1.08943654
138* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08464966
139ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.08267877
140NOTCH1_21737748_ChIP-Seq_TLL_Human1.07988864
141NANOG_18555785_Chip-Seq_ESCs_Mouse1.07143325
142NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06932920
143HOXB7_26014856_ChIP-Seq_BT474_Human1.06555487
144EZH2_27294783_Chip-Seq_NPCs_Mouse1.05910753
145CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05588470
146KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.05494267
147RUNX2_22187159_ChIP-Seq_PCA_Human1.04716056
148AR_21572438_ChIP-Seq_LNCaP_Human1.04676232
149P53_22387025_ChIP-Seq_ESCs_Mouse1.04639590
150TP63_19390658_ChIP-ChIP_HaCaT_Human1.04553132
151MYC_18358816_ChIP-ChIP_MESCs_Mouse1.03593108
152MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.03414333
153EED_16625203_ChIP-ChIP_MESCs_Mouse1.03057671
154EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02557358
155TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02523125
156STAT3_18555785_Chip-Seq_ESCs_Mouse1.02239943
157AR_20517297_ChIP-Seq_VCAP_Human1.01510551
158GATA1_19941826_ChIP-Seq_K562_Human1.00882588
159RNF2_27304074_Chip-Seq_NSC_Mouse1.00441407
160JARID2_20064375_ChIP-Seq_MESCs_Mouse0.99310581
161CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.99005575
162CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98883372
163KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98864466
164TDRD3_21172665_ChIP-Seq_MCF-7_Human0.98822989
165ELK1_19687146_ChIP-ChIP_HELA_Human0.98541451
166SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.98481133
167OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98433652
168RXR_22108803_ChIP-Seq_LS180_Human0.98349016
169GATA3_27048872_Chip-Seq_THYMUS_Human0.96133412
170GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94169722
171TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94088128
172ELF1_17652178_ChIP-ChIP_JURKAT_Human0.93701038
173KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.92935973
174* GATA3_26560356_Chip-Seq_TH2_Human0.92026297
175CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91067264
176CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88130735
177GATA2_19941826_ChIP-Seq_K562_Human0.87360075
178ELK3_25401928_ChIP-Seq_HUVEC_Human0.86902941
179EGR1_19032775_ChIP-ChIP_M12_Human0.85687303
180HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.85199542
181KDM2B_26808549_Chip-Seq_DND41_Human0.85132659
182HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.83427396
183CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82588677
184VDR_23849224_ChIP-Seq_CD4+_Human0.82188283
185E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.82113873
186FOXP3_21729870_ChIP-Seq_TREG_Human0.81448780
187SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80873511
188ETS1_22383799_ChIP-Seq_G1ME_Mouse0.79036458
189AR_21909140_ChIP-Seq_LNCAP_Human0.78683374
190PU.1_20513432_ChIP-Seq_Bcells_Mouse0.78048480
191SPI1_20517297_ChIP-Seq_HL60_Human0.77333150
192CLOCK_20551151_ChIP-Seq_293T_Human0.75804194
193EST1_17652178_ChIP-ChIP_JURKAT_Human0.75462347
194RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74645538
195DCP1A_22483619_ChIP-Seq_HELA_Human0.73758308
196CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73004472
197KDM2B_26808549_Chip-Seq_SUP-B15_Human0.72735239

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system4.21155148
2MP0000465_gastrointestinal_hemorrhage3.58351646
3MP0003195_calcinosis3.41434253
4MP0001545_abnormal_hematopoietic_system3.38276913
5MP0005397_hematopoietic_system_phenotyp3.38276913
6MP0005464_abnormal_platelet_physiology3.25068590
7MP0004808_abnormal_hematopoietic_stem3.20467061
8MP0003436_decreased_susceptibility_to2.92904698
9MP0002735_abnormal_chemical_nociception2.74852619
10MP0002419_abnormal_innate_immunity2.57844361
11MP0003724_increased_susceptibility_to2.49375652
12MP0000569_abnormal_digit_pigmentation2.48661116
13* MP0002148_abnormal_hypersensitivity_rea2.34457654
14MP0004885_abnormal_endolymph2.32719488
15MP0002398_abnormal_bone_marrow2.31900952
16MP0003693_abnormal_embryo_hatching2.28063040
17MP0005025_abnormal_response_to2.24954295
18MP0002138_abnormal_hepatobiliary_system2.22405532
19MP0005000_abnormal_immune_tolerance2.22093662
20MP0005671_abnormal_response_to2.20088108
21MP0001835_abnormal_antigen_presentation2.18548023
22* MP0002420_abnormal_adaptive_immunity2.18449647
23MP0001485_abnormal_pinna_reflex2.18175471
24MP0005551_abnormal_eye_electrophysiolog2.17262464
25* MP0001819_abnormal_immune_cell2.13828618
26MP0002876_abnormal_thyroid_physiology2.11955182
27MP0000858_altered_metastatic_potential2.09982027
28MP0003303_peritoneal_inflammation2.07719801
29MP0003300_gastrointestinal_ulcer2.07073354
30MP0003111_abnormal_nucleus_morphology2.02726715
31MP0001853_heart_inflammation2.02209867
32MP0001873_stomach_inflammation2.00370764
33MP0002722_abnormal_immune_system1.99995921
34MP0003646_muscle_fatigue1.99716476
35MP0000372_irregular_coat_pigmentation1.93123228
36MP0008007_abnormal_cellular_replicative1.91896623
37MP0008877_abnormal_DNA_methylation1.91253419
38MP0002166_altered_tumor_susceptibility1.87195909
39MP0001800_abnormal_humoral_immune1.86804299
40MP0002837_dystrophic_cardiac_calcinosis1.86726493
41MP0005387_immune_system_phenotype1.85934473
42MP0001790_abnormal_immune_system1.85934473
43MP0001348_abnormal_lacrimal_gland1.85928192
44MP0000716_abnormal_immune_system1.84065452
45MP0002733_abnormal_thermal_nociception1.82968679
46MP0009333_abnormal_splenocyte_physiolog1.82192208
47MP0010352_gastrointestinal_tract_polyps1.76806752
48MP0000689_abnormal_spleen_morphology1.75617153
49MP0006292_abnormal_olfactory_placode1.74335351
50MP0002452_abnormal_antigen_presenting1.74230796
51MP0003566_abnormal_cell_adhesion1.74180051
52MP0003763_abnormal_thymus_physiology1.71268088
53MP0000685_abnormal_immune_system1.70983709
54MP0002429_abnormal_blood_cell1.69207629
55MP0005171_absent_coat_pigmentation1.66275650
56MP0005174_abnormal_tail_pigmentation1.65955046
57MP0002653_abnormal_ependyma_morphology1.65358752
58MP0002102_abnormal_ear_morphology1.65033893
59MP0002160_abnormal_reproductive_system1.62247290
60* MP0002723_abnormal_immune_serum1.62195192
61MP0006054_spinal_hemorrhage1.61242556
62MP0001968_abnormal_touch/_nociception1.60899474
63MP0003136_yellow_coat_color1.57193570
64MP0004043_abnormal_pH_regulation1.55922120
65MP0001501_abnormal_sleep_pattern1.55564184
66MP0009745_abnormal_behavioral_response1.54913671
67MP0003283_abnormal_digestive_organ1.54490827
68MP0000631_abnormal_neuroendocrine_gland1.51904751
69MP0004133_heterotaxia1.50249436
70MP0009785_altered_susceptibility_to1.47985551
71MP0002405_respiratory_system_inflammati1.46918383
72MP0001533_abnormal_skeleton_physiology1.46244374
73MP0006072_abnormal_retinal_apoptosis1.45474054
74MP0002909_abnormal_adrenal_gland1.44703144
75MP0005389_reproductive_system_phenotype1.43386739
76MP0005253_abnormal_eye_physiology1.42820488
77MP0002272_abnormal_nervous_system1.41941930
78MP0001970_abnormal_pain_threshold1.41816375
79MP0004142_abnormal_muscle_tone1.41137554
80MP0000703_abnormal_thymus_morphology1.39725619
81MP0008875_abnormal_xenobiotic_pharmacok1.36416262
82MP0002277_abnormal_respiratory_mucosa1.35674065
83MP0004957_abnormal_blastocyst_morpholog1.35638517
84MP0004145_abnormal_muscle_electrophysio1.32955161
85MP0002006_tumorigenesis1.31741243
86MP0004947_skin_inflammation1.31697354
87MP0003638_abnormal_response/metabolism_1.31142759
88MP0005075_abnormal_melanosome_morpholog1.30929716
89MP0001986_abnormal_taste_sensitivity1.30383925
90MP0009046_muscle_twitch1.30068085
91MP0003656_abnormal_erythrocyte_physiolo1.29984592
92MP0002877_abnormal_melanocyte_morpholog1.29792647
93MP0001845_abnormal_inflammatory_respons1.26173819
94MP0004858_abnormal_nervous_system1.26130026
95MP0005448_abnormal_energy_balance1.25529582
96MP0000230_abnormal_systemic_arterial1.23873603
97MP0006276_abnormal_autonomic_nervous1.23668117
98MP0000490_abnormal_crypts_of1.23349334
99MP0000249_abnormal_blood_vessel1.22212872
100MP0002734_abnormal_mechanical_nocicepti1.20462683
101MP0008961_abnormal_basal_metabolism1.19983189
102MP0006082_CNS_inflammation1.19522880
103MP0010155_abnormal_intestine_physiology1.19473914
104MP0002928_abnormal_bile_duct1.19117146
105MP0002638_abnormal_pupillary_reflex1.18600987
106MP0001188_hyperpigmentation1.17617039
107MP0008775_abnormal_heart_ventricle1.17428580
108MP0003191_abnormal_cellular_cholesterol1.16873280
109MP0005646_abnormal_pituitary_gland1.15710433
110MP0003011_delayed_dark_adaptation1.13857405
111MP0008873_increased_physiological_sensi1.12511707
112MP0002938_white_spotting1.11271708
113MP0003252_abnormal_bile_duct1.11169205
114MP0005645_abnormal_hypothalamus_physiol1.10997857
115MP0001663_abnormal_digestive_system1.10928664
116MP0002572_abnormal_emotion/affect_behav1.09169345
117MP0005332_abnormal_amino_acid1.07826024
118MP0001440_abnormal_grooming_behavior1.07676544
119MP0004134_abnormal_chest_morphology1.07105703
120MP0008469_abnormal_protein_level1.06045193
121MP0002163_abnormal_gland_morphology1.04587768
122MP0004147_increased_porphyrin_level1.04371903
123MP0004130_abnormal_muscle_cell1.03912111
124MP0009379_abnormal_foot_pigmentation1.03403568
125MP0005085_abnormal_gallbladder_physiolo1.03127409
126MP0005310_abnormal_salivary_gland1.02769309
127MP0000383_abnormal_hair_follicle1.02571819
128MP0008872_abnormal_physiological_respon1.00505949
129MP0004742_abnormal_vestibular_system0.98910373
130MP0003866_abnormal_defecation0.98116845
131MP0003787_abnormal_imprinting0.97904914
132MP0000427_abnormal_hair_cycle0.96713269
133MP0009763_increased_sensitivity_to0.95392965
134MP0003718_maternal_effect0.94892748
135MP0002736_abnormal_nociception_after0.94817063
136MP0005167_abnormal_blood-brain_barrier0.94090173
137MP0002064_seizures0.93890744
138MP0005084_abnormal_gallbladder_morpholo0.93054566
139MP0005083_abnormal_biliary_tract0.92434960
140MP0009765_abnormal_xenobiotic_induced0.90835060
141MP0000049_abnormal_middle_ear0.90217895
142MP0009764_decreased_sensitivity_to0.90041428
143MP0005623_abnormal_meninges_morphology0.89648580
144MP0001486_abnormal_startle_reflex0.88889269
145MP0003172_abnormal_lysosome_physiology0.88524821
146MP0002557_abnormal_social/conspecific_i0.87743735
147MP0001963_abnormal_hearing_physiology0.87364122
148MP0003075_altered_response_to0.84850555
149MP0000026_abnormal_inner_ear0.82398874
150MP0000343_altered_response_to0.82326642
151MP0005195_abnormal_posterior_eye0.81430025
152MP0000015_abnormal_ear_pigmentation0.81381219
153MP0004019_abnormal_vitamin_homeostasis0.79754193
154MP0001958_emphysema0.79642680
155MP0005058_abnormal_lysosome_morphology0.79198441
156MP0010307_abnormal_tumor_latency0.76684256
157MP0002089_abnormal_postnatal_growth/wei0.76526990
158MP0008995_early_reproductive_senescence0.75578710
159MP0001765_abnormal_ion_homeostasis0.75348206
160MP0001324_abnormal_eye_pigmentation0.74394620
161MP0001919_abnormal_reproductive_system0.73656691
162MP0003329_amyloid_beta_deposits0.72663101
163MP0008770_decreased_survivor_rate0.72648108
164MP0008874_decreased_physiological_sensi0.72395775
165MP0002063_abnormal_learning/memory/cond0.70770736
166MP0002067_abnormal_sensory_capabilities0.70517810
167MP0003878_abnormal_ear_physiology0.70210291
168MP0005377_hearing/vestibular/ear_phenot0.70210291
169MP0010329_abnormal_lipoprotein_level0.70043450
170MP0002019_abnormal_tumor_incidence0.69369947
171MP0005584_abnormal_enzyme/coenzyme_acti0.66829748
172MP0002095_abnormal_skin_pigmentation0.66480821
173MP0003077_abnormal_cell_cycle0.65118020
174MP0001851_eye_inflammation0.63363331
175MP0005330_cardiomyopathy0.58600266
176MP0005165_increased_susceptibility_to0.58065041
177MP0003795_abnormal_bone_structure0.56289767
178MP0000920_abnormal_myelination0.54825996
179MP0005381_digestive/alimentary_phenotyp0.54730482

Predicted human phenotypes

RankGene SetZ-score
1Petechiae (HP:0000967)9.73060212
2Aplastic anemia (HP:0001915)7.32154712
3Prolonged bleeding time (HP:0003010)6.97918188
4Abnormal platelet volume (HP:0011876)6.45134397
5Increased mean platelet volume (HP:0011877)6.32933552
6Abnormal platelet function (HP:0011869)6.12990296
7Impaired platelet aggregation (HP:0003540)6.12990296
8Purpura (HP:0000979)5.70791439
9Gingival bleeding (HP:0000225)5.07655270
10Menorrhagia (HP:0000132)4.94865916
11Abnormal number of erythroid precursors (HP:0012131)4.70458127
12Abnormality of cells of the erythroid lineage (HP:0012130)4.59377613
13Epistaxis (HP:0000421)4.17139999
14Pancreatic cysts (HP:0001737)4.14141555
15Recurrent bacterial skin infections (HP:0005406)4.12171288
16Chronic otitis media (HP:0000389)3.84992061
17True hermaphroditism (HP:0010459)3.80086919
18Pancreatic fibrosis (HP:0100732)3.78201497
19Cellulitis (HP:0100658)3.77140271
20Abolished electroretinogram (ERG) (HP:0000550)3.75115677
21Congenital stationary night blindness (HP:0007642)3.74985812
22Recurrent abscess formation (HP:0002722)3.52967382
23Thrombocytosis (HP:0001894)3.40140301
24Pendular nystagmus (HP:0012043)3.35873147
25Molar tooth sign on MRI (HP:0002419)3.28174707
26Abnormality of midbrain morphology (HP:0002418)3.28174707
27Nephronophthisis (HP:0000090)3.20306797
28Decreased central vision (HP:0007663)3.17916695
29Recurrent fungal infections (HP:0002841)3.12804526
30Absent rod-and cone-mediated responses on ERG (HP:0007688)3.11401437
31Abnormal rod and cone electroretinograms (HP:0008323)2.99941786
32Recurrent viral infections (HP:0004429)2.93385042
33IgM deficiency (HP:0002850)2.93033918
34Attenuation of retinal blood vessels (HP:0007843)2.92633140
35Nasal polyposis (HP:0100582)2.91627205
36Abnormality of the renal cortex (HP:0011035)2.82478310
37Increased corneal curvature (HP:0100692)2.80320762
38Keratoconus (HP:0000563)2.80320762
39Abnormality of the renal medulla (HP:0100957)2.80123805
40Furrowed tongue (HP:0000221)2.73043696
41Leukocytosis (HP:0001974)2.68381068
42Vacuolated lymphocytes (HP:0001922)2.64506296
43Congenital, generalized hypertrichosis (HP:0004540)2.63234212
44Progressive inability to walk (HP:0002505)2.58257119
45Type II lissencephaly (HP:0007260)2.58002983
46Poikilocytosis (HP:0004447)2.57630075
47Acute myeloid leukemia (HP:0004808)2.57429869
48Pallor (HP:0000980)2.57239606
49Myelodysplasia (HP:0002863)2.57238270
50Bruising susceptibility (HP:0000978)2.55470702
51Decreased circulating renin level (HP:0003351)2.55193012
52Inability to walk (HP:0002540)2.52229330
533-Methylglutaconic aciduria (HP:0003535)2.48994651
54Polydipsia (HP:0001959)2.47937120
55Abnormal drinking behavior (HP:0030082)2.47937120
56Broad face (HP:0000283)2.47807095
57Hyperventilation (HP:0002883)2.47205550
58Decreased electroretinogram (ERG) amplitude (HP:0000654)2.45133864
59Abnormality of the heme biosynthetic pathway (HP:0010472)2.44289638
60Abnormality of lateral ventricle (HP:0030047)2.43908762
61Congenital sensorineural hearing impairment (HP:0008527)2.41665459
62Abnormality of the nasal mucosa (HP:0000433)2.40825890
63Eczematoid dermatitis (HP:0000976)2.39711257
64Acute lymphatic leukemia (HP:0006721)2.37825248
65Chorioretinal atrophy (HP:0000533)2.35866145
66Elevated erythrocyte sedimentation rate (HP:0003565)2.35000895
67Reticulocytopenia (HP:0001896)2.34455938
68Tubular atrophy (HP:0000092)2.33110559
69Cystic liver disease (HP:0006706)2.32634791
70Diminished motivation (HP:0000745)2.30938988
7111 pairs of ribs (HP:0000878)2.30908760
72Absent/shortened dynein arms (HP:0200106)2.30905801
73Dynein arm defect of respiratory motile cilia (HP:0012255)2.30905801
74Acanthocytosis (HP:0001927)2.28934944
75Thoracic kyphosis (HP:0002942)2.28897673
76Genetic anticipation (HP:0003743)2.28795577
77Abnormality of the renal collecting system (HP:0004742)2.27753674
78Type 2 muscle fiber atrophy (HP:0003554)2.27257725
79Severe visual impairment (HP:0001141)2.27208155
80IgG deficiency (HP:0004315)2.24725614
81Aplasia/Hypoplasia of the tibia (HP:0005772)2.24423125
82Abnormality of the prostate (HP:0008775)2.24277545
83Sclerocornea (HP:0000647)2.22001965
84Gaze-evoked nystagmus (HP:0000640)2.21467396
85Recurrent skin infections (HP:0001581)2.20539643
86Conjunctival hamartoma (HP:0100780)2.20146842
87Increased neuronal autofluorescent lipopigment (HP:0002074)2.19098999
88Papilledema (HP:0001085)2.17884959
89Agitation (HP:0000713)2.15534936
90Abnormality of macular pigmentation (HP:0008002)2.14919118
91Progressive cerebellar ataxia (HP:0002073)2.14238943
92Recurrent gram-negative bacterial infections (HP:0005420)2.14136466
93Asplenia (HP:0001746)2.13765637
94Chronic hepatic failure (HP:0100626)2.13180480
95Abnormality of the thoracic spine (HP:0100711)2.12665592
96Aplasia/Hypoplasia of the spleen (HP:0010451)2.12143112
97Hypoplasia of the thymus (HP:0000778)2.11381053
98Stomach cancer (HP:0012126)2.11122762
99Apathy (HP:0000741)2.10569590
100Interstitial pulmonary disease (HP:0006530)2.09153759
101Inappropriate behavior (HP:0000719)2.05944640
102Broad palm (HP:0001169)2.05485921
103Stenosis of the external auditory canal (HP:0000402)2.04801898
104Myositis (HP:0100614)2.04105831
105Confusion (HP:0001289)2.03852571
106Abnormality of the lumbar spine (HP:0100712)2.02636411
107Abnormality of alanine metabolism (HP:0010916)2.00286827
108Hyperalaninemia (HP:0003348)2.00286827
109Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.00286827
110Bony spicule pigmentary retinopathy (HP:0007737)1.99714700
111Alveolar cell carcinoma (HP:0006519)1.98516440
112Acute necrotizing encephalopathy (HP:0006965)1.96700022
113Male pseudohermaphroditism (HP:0000037)1.96598599
114Heterochromia iridis (HP:0001100)1.95487876
115Increased cerebral lipofuscin (HP:0011813)1.95281191
116Lower limb hyperreflexia (HP:0002395)1.95098700
117Encephalitis (HP:0002383)1.95006284
118Congenital hepatic fibrosis (HP:0002612)1.94094684
119Nonprogressive disorder (HP:0003680)1.93543245
120Polyuria (HP:0000103)1.92507112
121Pustule (HP:0200039)1.92026026
122Hyperacusis (HP:0010780)1.91404320
123Abnormal delayed hypersensitivity skin test (HP:0002963)1.90420338
124Muscle fiber atrophy (HP:0100295)1.89320501
125Anencephaly (HP:0002323)1.88547696
126Absent thumb (HP:0009777)1.88268021
127Medial flaring of the eyebrow (HP:0010747)1.88206330
128Hypothermia (HP:0002045)1.87039454
129Mediastinal lymphadenopathy (HP:0100721)1.84600168
130Aplasia/Hypoplasia of the hallux (HP:0008362)1.82668169
131Abnormality of reticulocytes (HP:0004312)1.82525137
132Pancytopenia (HP:0001876)1.81988405
133Short hallux (HP:0010109)1.81456805
134Lymphopenia (HP:0001888)1.81387560
135Renal cortical cysts (HP:0000803)1.81243591
136Insomnia (HP:0100785)1.80952949
137Abnormality of DNA repair (HP:0003254)1.80799100
138Abnormality of macrophages (HP:0004311)1.80751615
139Optic disc pallor (HP:0000543)1.78887417
140Neoplasm of the tracheobronchial system (HP:0100552)1.78063166
141Poor eye contact (HP:0000817)1.78051215
142Increased CSF lactate (HP:0002490)1.77475587
143Metabolic alkalosis (HP:0200114)1.76979140
144Inflammation of the large intestine (HP:0002037)1.76797243
145Stomatitis (HP:0010280)1.76351040
146Hamartoma of the eye (HP:0010568)1.75907109
147Mitochondrial inheritance (HP:0001427)1.75642177
148Aplasia/Hypoplasia of the tongue (HP:0010295)1.75382854
149Progressive macrocephaly (HP:0004481)1.74315131
150Duplicated collecting system (HP:0000081)1.73103019
151Abnormality of the nasal septum (HP:0000419)1.72300376
152Aplasia/Hypoplasia of the patella (HP:0006498)1.71834833
153Pancreatic islet-cell hyperplasia (HP:0004510)1.71170143
154Chest pain (HP:0100749)1.70861264
155Bone cyst (HP:0012062)1.70373453
156Abnormal ciliary motility (HP:0012262)1.69974977
157Macular degeneration (HP:0000608)1.69949230
158Abnormality of the phalanges of the 2nd finger (HP:0009541)1.69360813
159Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.68956186
160Short 1st metacarpal (HP:0010034)1.68956186
161Short tibia (HP:0005736)1.68858562
162Bone marrow hypocellularity (HP:0005528)1.68484912
163Abnormality of the axillary hair (HP:0100134)1.68310980
164Abnormality of secondary sexual hair (HP:0009888)1.68310980
165Abnormality of cells of the lymphoid lineage (HP:0012140)1.67746694
166Concave nail (HP:0001598)1.67193287
167Tachypnea (HP:0002789)1.67193196
168Ectopic kidney (HP:0000086)1.66580669
169Hematochezia (HP:0002573)1.66536446
170Methylmalonic acidemia (HP:0002912)1.66500670
171Small hand (HP:0200055)1.66224295
172Gastrointestinal inflammation (HP:0004386)1.65631817
173Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.65460109
174Disinhibition (HP:0000734)1.65431255
175Clumsiness (HP:0002312)1.64885897
176Abnormality of eosinophils (HP:0001879)1.64370974
177Hyperglycinuria (HP:0003108)1.64189564
178Easy fatigability (HP:0003388)1.64032815
179Abnormality of T cell physiology (HP:0011840)1.63605120
180Chronic obstructive pulmonary disease (HP:0006510)1.63129003
181Obstructive lung disease (HP:0006536)1.63129003
182Abnormal respiratory epithelium morphology (HP:0012253)1.62884924
183Neutropenia (HP:0001875)1.62686969
184Impaired social interactions (HP:0000735)1.61887919
185Abnormal social behavior (HP:0012433)1.61887919
186Dysostosis multiplex (HP:0000943)1.57500337
187Eosinophilia (HP:0001880)1.56698262
188Reticulocytosis (HP:0001923)1.53314062
189Nonimmune hydrops fetalis (HP:0001790)1.51850405
190Thoracolumbar scoliosis (HP:0002944)1.51312569
191Ankle clonus (HP:0011448)1.50559505
192Thyroid-stimulating hormone excess (HP:0002925)1.48073729
193Meningitis (HP:0001287)1.47908352
194Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.47771412
195Macrocytic anemia (HP:0001972)1.46377632
196Hyperbilirubinemia (HP:0002904)1.45600454
197Osteomyelitis (HP:0002754)1.45367263
198Acrocyanosis (HP:0001063)1.44900937
199Mucopolysacchariduria (HP:0008155)1.44004457

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.00481445
2KIT4.59221357
3MAP3K124.58722801
4ADRBK23.70180764
5EEF2K3.18275670
6TRIM282.96314901
7TAOK32.90734578
8TNIK2.88454084
9BMPR1B2.70684863
10ACVR1B2.60730490
11FES2.49587414
12BLK2.47608746
13WNK42.41013072
14PIM22.33724883
15STK162.31178876
16ZAK2.29074287
17TEC2.27306185
18NUAK12.19890991
19BUB12.19605881
20WNK32.14367225
21MATK2.13180590
22STK102.10175957
23BTK2.08649920
24VRK12.04448383
25WEE11.86147280
26PINK11.83071398
27MAP4K21.81970325
28NME21.80524382
29GRK61.75751087
30SCYL21.75261308
31RIPK41.73093736
32TLK11.63964729
33DAPK21.59760131
34MAP4K11.59636177
35MAPK131.57255803
36INSRR1.55376972
37DYRK31.48806265
38SYK1.46662855
39TAF11.45470369
40ITK1.44281566
41MYLK1.44131817
42LRRK21.36559416
43MAPKAPK31.36194475
44STK391.33546011
45RPS6KB21.32780831
46ADRBK11.30702503
47PNCK1.29285535
48DAPK11.27374126
49TIE11.26103276
50CLK11.23693806
51JAK21.23585033
52MAP3K41.22663703
53OXSR11.22632268
54RAF11.17985781
55CDK191.17127610
56CDK61.15750516
57LYN1.15219762
58NTRK21.14946775
59MAPKAPK51.12661327
60IKBKB1.10871077
61STK38L1.09799067
62NEK21.07438874
63GRK71.07338624
64TXK1.06761044
65MAP3K81.04385648
66RPS6KA41.00935415
67MAP2K61.00312759
68BRSK10.99904776
69PRKD20.97997146
70HIPK20.96351497
71PRKCE0.96129317
72CAMKK20.95731050
73PDK20.94730487
74MAPKAPK20.94243010
75EIF2AK30.90715622
76TTN0.90307373
77MST40.87062463
78PAK40.87001675
79BRSK20.86370690
80IRAK40.86051263
81TGFBR20.85210990
82PAK20.84641234
83MAPK40.83827263
84MAP2K20.83496369
85PIK3CG0.83430067
86GRK10.83017164
87ILK0.82251891
88JAK30.80374284
89DYRK20.80240115
90PAK30.80075429
91CDK70.79336184
92TRPM70.79033142
93CASK0.78813580
94CSNK1G30.78653794
95FER0.76265444
96IRAK10.75428881
97PTK2B0.75353088
98CAMKK10.74764621
99PIK3CA0.73321088
100PRKCQ0.72360760
101CSNK1A1L0.70326825
102PLK20.69736343
103MUSK0.69399218
104PRKCG0.67229167
105TYK20.66213491
106TGFBR10.65021550
107WNK10.64807297
108PKN20.64689410
109STK30.64153757
110NLK0.63650695
111RPS6KA50.62754378
112MAP3K70.62108152
113GRK50.61580055
114MAPK110.60400336
115CHUK0.60138974
116ERN10.59833371
117ZAP700.59430568
118VRK20.58973369
119LCK0.58095211
120AURKB0.58073203
121PRKACA0.57562311
122PIM10.57520273
123MAP2K70.56477379
124IKBKE0.53988138
125ATR0.53956959
126BCKDK0.52972215
127CDK40.52952678
128MKNK10.52567487
129PRKCI0.51780588
130PRKCH0.51294087
131MARK30.51214089
132RPS6KA60.50409566
133EPHA30.50311380
134EPHB10.49650755
135MAPK150.49072443
136MAP3K60.49071379
137JAK10.49036381
138CAMK10.48954300
139STK110.48779082
140ERBB20.48167682
141CSNK1G20.47900881
142CAMK2A0.47355437
143NME10.47037898
144PKN10.46291008
145MAP2K10.46216145
146ALK0.45386496
147STK40.45335643
148PRKCA0.45212570
149NTRK30.44504969
150CAMK1D0.44378298
151IGF1R0.42740353
152CSF1R0.41450597
153HCK0.41367564
154MAP2K30.39278627
155TRIB30.39269682
156CSNK1A10.37719031
157TNK20.37360455
158ABL10.35872550
159UHMK10.34544430
160PRKCZ0.34542940
161PRKAA20.33898725
162RPS6KA20.32966333
163MAP3K110.32523852
164MKNK20.31484581
165TBK10.30046094
166CSNK1G10.29398634
167AURKA0.29123904
168PTK60.29055947
169CAMK1G0.27297540
170DAPK30.26226007
171PRKACG0.25776495
172CDC70.25073143
173FGFR40.24430351

Predicted pathways (KEGG)

RankGene SetZ-score
1Renin-angiotensin system_Homo sapiens_hsa046147.81864040
2* Asthma_Homo sapiens_hsa053106.39720401
3Phototransduction_Homo sapiens_hsa047442.69159372
4Ribosome_Homo sapiens_hsa030102.68447380
5* Fc epsilon RI signaling pathway_Homo sapiens_hsa046642.63136836
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.51084313
7Hematopoietic cell lineage_Homo sapiens_hsa046402.49442972
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.38071412
9Linoleic acid metabolism_Homo sapiens_hsa005912.37511217
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.22015263
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.07362272
12Nicotine addiction_Homo sapiens_hsa050332.01486709
13Platelet activation_Homo sapiens_hsa046112.00765007
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.94754205
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.92566934
16Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.86473989
17DNA replication_Homo sapiens_hsa030301.84352234
18Caffeine metabolism_Homo sapiens_hsa002321.80233121
19Leishmaniasis_Homo sapiens_hsa051401.73511722
20N-Glycan biosynthesis_Homo sapiens_hsa005101.73012301
21Oxidative phosphorylation_Homo sapiens_hsa001901.71103963
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.70790174
23B cell receptor signaling pathway_Homo sapiens_hsa046621.68841438
24Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.68378583
25Other glycan degradation_Homo sapiens_hsa005111.67260589
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.66481460
27Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.66014111
28Chemical carcinogenesis_Homo sapiens_hsa052041.60597805
29Small cell lung cancer_Homo sapiens_hsa052221.58882943
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.53831914
31Ether lipid metabolism_Homo sapiens_hsa005651.53810203
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.46502514
33Butanoate metabolism_Homo sapiens_hsa006501.46073399
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.45024612
35Morphine addiction_Homo sapiens_hsa050321.44564781
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.43763228
37Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.43163163
38Olfactory transduction_Homo sapiens_hsa047401.42492650
39Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.39948165
40Retinol metabolism_Homo sapiens_hsa008301.38882178
41Basal transcription factors_Homo sapiens_hsa030221.38657812
42Arachidonic acid metabolism_Homo sapiens_hsa005901.30507564
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29536946
44Non-small cell lung cancer_Homo sapiens_hsa052231.26299906
45p53 signaling pathway_Homo sapiens_hsa041151.23562752
46Taste transduction_Homo sapiens_hsa047421.22070573
47Selenocompound metabolism_Homo sapiens_hsa004501.21923301
48Autoimmune thyroid disease_Homo sapiens_hsa053201.16460438
49Acute myeloid leukemia_Homo sapiens_hsa052211.15332909
50Parkinsons disease_Homo sapiens_hsa050121.15081885
51RNA polymerase_Homo sapiens_hsa030201.14141742
52Sulfur metabolism_Homo sapiens_hsa009201.14092637
53Vitamin digestion and absorption_Homo sapiens_hsa049771.11880126
54Osteoclast differentiation_Homo sapiens_hsa043801.07871069
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.07525740
56Graft-versus-host disease_Homo sapiens_hsa053321.06982368
57Glycerolipid metabolism_Homo sapiens_hsa005611.06944861
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.06151383
59Chronic myeloid leukemia_Homo sapiens_hsa052201.05011403
60Fanconi anemia pathway_Homo sapiens_hsa034601.03300535
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.01950396
62Nitrogen metabolism_Homo sapiens_hsa009101.00684174
63ABC transporters_Homo sapiens_hsa020101.00226905
64Protein export_Homo sapiens_hsa030600.95580747
65Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.95371659
66Peroxisome_Homo sapiens_hsa041460.94923239
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.94743106
68Toxoplasmosis_Homo sapiens_hsa051450.93006288
69Hepatitis B_Homo sapiens_hsa051610.92912881
70Serotonergic synapse_Homo sapiens_hsa047260.91808509
71Cardiac muscle contraction_Homo sapiens_hsa042600.91496569
72Insulin secretion_Homo sapiens_hsa049110.91015762
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90922773
74Intestinal immune network for IgA production_Homo sapiens_hsa046720.88838424
75Dorso-ventral axis formation_Homo sapiens_hsa043200.88108864
76Cell cycle_Homo sapiens_hsa041100.87599635
77Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.87393062
78Fat digestion and absorption_Homo sapiens_hsa049750.87048855
79Type I diabetes mellitus_Homo sapiens_hsa049400.86974571
80Spliceosome_Homo sapiens_hsa030400.86171333
81Alzheimers disease_Homo sapiens_hsa050100.85495617
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.84216754
83Measles_Homo sapiens_hsa051620.84192211
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.82446609
85GABAergic synapse_Homo sapiens_hsa047270.82271502
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82078425
87Huntingtons disease_Homo sapiens_hsa050160.80621814
88Apoptosis_Homo sapiens_hsa042100.77710006
89Thyroid cancer_Homo sapiens_hsa052160.73471958
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73351512
91Circadian entrainment_Homo sapiens_hsa047130.73099416
92ECM-receptor interaction_Homo sapiens_hsa045120.72677903
93Pyrimidine metabolism_Homo sapiens_hsa002400.72577863
94Antigen processing and presentation_Homo sapiens_hsa046120.72165442
95RNA degradation_Homo sapiens_hsa030180.71372559
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71128418
97* Sphingolipid signaling pathway_Homo sapiens_hsa040710.68632098
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68406485
99Viral carcinogenesis_Homo sapiens_hsa052030.67973052
100Mismatch repair_Homo sapiens_hsa034300.67193200
101Glutamatergic synapse_Homo sapiens_hsa047240.66927209
102Histidine metabolism_Homo sapiens_hsa003400.66088207
103Salivary secretion_Homo sapiens_hsa049700.65133059
104Shigellosis_Homo sapiens_hsa051310.64857892
105Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64570148
106Colorectal cancer_Homo sapiens_hsa052100.64201130
107Calcium signaling pathway_Homo sapiens_hsa040200.63125377
108Rheumatoid arthritis_Homo sapiens_hsa053230.62877167
109Collecting duct acid secretion_Homo sapiens_hsa049660.62791577
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62715709
111Mineral absorption_Homo sapiens_hsa049780.60869165
112Starch and sucrose metabolism_Homo sapiens_hsa005000.60273736
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57712492
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.57622330
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57516602
116AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57461124
117Glioma_Homo sapiens_hsa052140.54964074
118* Phospholipase D signaling pathway_Homo sapiens_hsa040720.53005571
119Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52738207
120Herpes simplex infection_Homo sapiens_hsa051680.52552770
121Staphylococcus aureus infection_Homo sapiens_hsa051500.52272220
122Tryptophan metabolism_Homo sapiens_hsa003800.51742203
123Primary immunodeficiency_Homo sapiens_hsa053400.51522461
124Drug metabolism - other enzymes_Homo sapiens_hsa009830.51246789
125Pentose phosphate pathway_Homo sapiens_hsa000300.50612681
126Regulation of autophagy_Homo sapiens_hsa041400.49677589
127Cocaine addiction_Homo sapiens_hsa050300.49493326
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49149893
129Cyanoamino acid metabolism_Homo sapiens_hsa004600.48938420
130Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46750061
131Gap junction_Homo sapiens_hsa045400.46129287
132Phagosome_Homo sapiens_hsa041450.46104766
133Salmonella infection_Homo sapiens_hsa051320.45866949
134Dopaminergic synapse_Homo sapiens_hsa047280.44703052
135Glycosaminoglycan degradation_Homo sapiens_hsa005310.44578466
136Propanoate metabolism_Homo sapiens_hsa006400.43894470
137SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42808113
138Neurotrophin signaling pathway_Homo sapiens_hsa047220.42744079
139Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42666411
140PI3K-Akt signaling pathway_Homo sapiens_hsa041510.42603596
141Long-term depression_Homo sapiens_hsa047300.42567232
142Renin secretion_Homo sapiens_hsa049240.42401698
143Chemokine signaling pathway_Homo sapiens_hsa040620.41271156
144Ovarian steroidogenesis_Homo sapiens_hsa049130.40861806
145Pertussis_Homo sapiens_hsa051330.40570546
146Homologous recombination_Homo sapiens_hsa034400.39919756
147beta-Alanine metabolism_Homo sapiens_hsa004100.39277610
148T cell receptor signaling pathway_Homo sapiens_hsa046600.38549823
149Rap1 signaling pathway_Homo sapiens_hsa040150.37991706
150Vascular smooth muscle contraction_Homo sapiens_hsa042700.37624826
151Metabolic pathways_Homo sapiens_hsa011000.36991556
152Focal adhesion_Homo sapiens_hsa045100.36656184
153VEGF signaling pathway_Homo sapiens_hsa043700.36153276
154Primary bile acid biosynthesis_Homo sapiens_hsa001200.35936990
155Alcoholism_Homo sapiens_hsa050340.35876222
156Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.35791408
157Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35297535
158Tuberculosis_Homo sapiens_hsa051520.34137665
159Cholinergic synapse_Homo sapiens_hsa047250.31977717
160Non-homologous end-joining_Homo sapiens_hsa034500.30725485
161Pancreatic secretion_Homo sapiens_hsa049720.28498808
162Systemic lupus erythematosus_Homo sapiens_hsa053220.28430715
163Purine metabolism_Homo sapiens_hsa002300.28104346
164Pathways in cancer_Homo sapiens_hsa052000.27765925
165Allograft rejection_Homo sapiens_hsa053300.27310843
166Melanoma_Homo sapiens_hsa052180.27187297
167Pancreatic cancer_Homo sapiens_hsa052120.27027588
168Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.26182376
169TNF signaling pathway_Homo sapiens_hsa046680.25499360
170One carbon pool by folate_Homo sapiens_hsa006700.25462634
171Thyroid hormone synthesis_Homo sapiens_hsa049180.24818562
172Protein digestion and absorption_Homo sapiens_hsa049740.23971290
173NF-kappa B signaling pathway_Homo sapiens_hsa040640.23704274
174Amoebiasis_Homo sapiens_hsa051460.20937488

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