MS4A3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the membrane-spanning 4A gene family. Members of this protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member likely plays a role in signal transduction and may function as a subunit associated with receptor complexes. The gene encoding this protein is localized to 11q12, among a cluster of related family members. Alternative splicing may result in multiple transcript variants; however, not all variants have been fully described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1killing of cells in other organism involved in symbiotic interaction (GO:0051883)9.91694531
2disruption of cells of other organism involved in symbiotic interaction (GO:0051818)9.91694531
3neutrophil mediated immunity (GO:0002446)8.99531046
4negative regulation of growth of symbiont in host (GO:0044130)7.62770366
5negative regulation of growth of symbiont involved in interaction with host (GO:0044146)7.62770366
6modulation of growth of symbiont involved in interaction with host (GO:0044144)7.62770366
7regulation of growth of symbiont in host (GO:0044126)7.62770366
8killing of cells of other organism (GO:0031640)7.51111828
9disruption of cells of other organism (GO:0044364)7.51111828
10negative regulation of phagocytosis (GO:0050765)7.34560480
11defense response to fungus (GO:0050832)7.31671646
12myeloid leukocyte mediated immunity (GO:0002444)7.28580570
13response to fungus (GO:0009620)6.93120123
14innate immune response in mucosa (GO:0002227)6.79579832
15cellular extravasation (GO:0045123)6.70336963
16cell wall macromolecule catabolic process (GO:0016998)6.52724655
17antibacterial humoral response (GO:0019731)5.93612486
18positive regulation of interleukin-8 biosynthetic process (GO:0045416)5.62448278
19antimicrobial humoral response (GO:0019730)5.44572102
20mucosal immune response (GO:0002385)5.43654229
21cell wall macromolecule metabolic process (GO:0044036)5.39438161
22leukocyte mediated cytotoxicity (GO:0001909)5.20025515
23organ or tissue specific immune response (GO:0002251)5.18635183
24cellular response to zinc ion (GO:0071294)5.02828359
25DNA deamination (GO:0045006)4.95799495
26respiratory burst (GO:0045730)4.95771859
27reactive oxygen species biosynthetic process (GO:1903409)4.90425586
28positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.82704007
29protoporphyrinogen IX metabolic process (GO:0046501)4.80679010
30ribosomal small subunit assembly (GO:0000028)4.41309492
31DNA strand elongation involved in DNA replication (GO:0006271)4.39916382
32telomere maintenance via semi-conservative replication (GO:0032201)4.37237772
33imidazole-containing compound metabolic process (GO:0052803)4.37121901
34pentose-phosphate shunt (GO:0006098)4.27497565
35positive regulation of B cell differentiation (GO:0045579)4.24838070
36DNA strand elongation (GO:0022616)4.21065414
37NADPH regeneration (GO:0006740)4.02569679
38cell killing (GO:0001906)3.87882761
39positive regulation of gamma-delta T cell activation (GO:0046645)3.86977310
40protein localization to kinetochore (GO:0034501)3.79356771
41regulation of interleukin-8 biosynthetic process (GO:0045414)3.76173361
42hemoglobin metabolic process (GO:0020027)3.76127650
43microglial cell activation (GO:0001774)3.73684387
44glucose 6-phosphate metabolic process (GO:0051156)3.71088936
45negative regulation of bone mineralization (GO:0030502)3.69569627
46positive regulation of mast cell activation involved in immune response (GO:0033008)3.69424768
47positive regulation of mast cell degranulation (GO:0043306)3.69424768
48regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.68438321
49leukotriene biosynthetic process (GO:0019370)3.66542058
50telomere maintenance via recombination (GO:0000722)3.66399957
51positive regulation of granulocyte differentiation (GO:0030854)3.65313005
52DNA replication initiation (GO:0006270)3.64848362
53regulation of mast cell degranulation (GO:0043304)3.62384300
54sequestering of metal ion (GO:0051238)3.62245673
55pentose metabolic process (GO:0019321)3.60394126
56angiotensin maturation (GO:0002003)3.60075739
57neutrophil activation involved in immune response (GO:0002283)3.59562261
58defense response to Gram-positive bacterium (GO:0050830)3.56765980
59oxygen transport (GO:0015671)3.52258767
60DNA unwinding involved in DNA replication (GO:0006268)3.51593375
61regulation of chemokine biosynthetic process (GO:0045073)3.51192501
62granulocyte activation (GO:0036230)3.49469814
63regulation of mast cell activation involved in immune response (GO:0033006)3.47302337
64regulation of myeloid leukocyte mediated immunity (GO:0002886)3.47135072
65negative regulation of chemokine production (GO:0032682)3.46468458
66interaction with symbiont (GO:0051702)3.45084297
67Arp2/3 complex-mediated actin nucleation (GO:0034314)3.43278942
68negative regulation of erythrocyte differentiation (GO:0045647)3.42043858
69IMP metabolic process (GO:0046040)3.40591603
70mitotic recombination (GO:0006312)3.37118718
71definitive hemopoiesis (GO:0060216)3.35895243
72detection of other organism (GO:0098543)3.33719312
73regulation of MHC class II biosynthetic process (GO:0045346)3.33291661
74DNA replication checkpoint (GO:0000076)3.32043313
75positive regulation of mast cell activation (GO:0033005)3.31687465
76leukocyte degranulation (GO:0043299)3.29835053
77leukocyte migration involved in inflammatory response (GO:0002523)3.29745641
78response to muramyl dipeptide (GO:0032495)3.27645103
79protein localization to chromosome, centromeric region (GO:0071459)3.25073997
80secretory granule organization (GO:0033363)3.23658993
81SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.23266643
82hydrogen peroxide catabolic process (GO:0042744)3.20956141
83detection of bacterium (GO:0016045)3.20428266
84response to peptidoglycan (GO:0032494)3.20265185
85defense response to bacterium (GO:0042742)3.19876504
86regulation of female gonad development (GO:2000194)3.19777913
87leukotriene metabolic process (GO:0006691)3.18063991
88cotranslational protein targeting to membrane (GO:0006613)3.17007147
89negative regulation of biomineral tissue development (GO:0070168)3.14845668
90leukocyte aggregation (GO:0070486)3.14516703
91protein targeting to ER (GO:0045047)3.13807875
92peptide catabolic process (GO:0043171)3.12499028
93positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.10395476
94telomere maintenance via telomere lengthening (GO:0010833)3.10353448
95signal peptide processing (GO:0006465)3.09929090
96regulation of leukocyte degranulation (GO:0043300)3.09646658
97low-density lipoprotein particle remodeling (GO:0034374)3.09470899
98modification by host of symbiont morphology or physiology (GO:0051851)3.04664005
99natural killer cell activation involved in immune response (GO:0002323)3.04490370
100negative regulation of interleukin-8 production (GO:0032717)3.03600574
101regulation of mast cell activation (GO:0033003)3.03558991
102nucleobase-containing small molecule interconversion (GO:0015949)3.03448350
103IMP biosynthetic process (GO:0006188)3.01009317
104protein localization to endoplasmic reticulum (GO:0070972)3.00540098
105angiogenesis involved in wound healing (GO:0060055)2.99694355
106establishment of protein localization to endoplasmic reticulum (GO:0072599)2.97696563
107gas transport (GO:0015669)2.96030723
108nucleobase biosynthetic process (GO:0046112)2.94545370
109porphyrin-containing compound biosynthetic process (GO:0006779)2.93606839
110macrophage differentiation (GO:0030225)2.93475320
111antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.90233738
112antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.90233738
113glucose catabolic process (GO:0006007)2.88247618
114CENP-A containing nucleosome assembly (GO:0034080)2.87127942
115regulation of B cell differentiation (GO:0045577)2.85433713
116centriole replication (GO:0007099)2.83863200
117myeloid cell activation involved in immune response (GO:0002275)2.83492947
118regulation of regulated secretory pathway (GO:1903305)2.83430495
119regulation of hypersensitivity (GO:0002883)2.82640098
120kinetochore organization (GO:0051383)2.81946096
121purine deoxyribonucleotide catabolic process (GO:0009155)2.80671529
122response to bacterium (GO:0009617)2.79120461
123nucleotide-excision repair, DNA gap filling (GO:0006297)2.78802972
124mast cell activation (GO:0045576)2.78170732
125viral transcription (GO:0019083)2.74476275
126chromatin remodeling at centromere (GO:0031055)2.73930546
127positive regulation of regulated secretory pathway (GO:1903307)2.73928648
128translational termination (GO:0006415)2.68808461
129DNA topological change (GO:0006265)2.68627014
130intra-S DNA damage checkpoint (GO:0031573)2.65968107
131negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.65440781
132macrophage activation (GO:0042116)2.64503903
133regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.58884306
134regulation of gamma-delta T cell differentiation (GO:0045586)2.57315968
135pinocytosis (GO:0006907)2.57183564
136B cell receptor signaling pathway (GO:0050853)2.56527102
137erythrocyte development (GO:0048821)2.54667182
138translational elongation (GO:0006414)2.53456943
139regulation of phagocytosis (GO:0050764)2.53435307
140ether lipid metabolic process (GO:0046485)2.53406034
141regulation of interleukin-6 biosynthetic process (GO:0045408)2.53335645
142mitotic nuclear envelope disassembly (GO:0007077)2.51926422
143tetrapyrrole biosynthetic process (GO:0033014)2.51813197
144attachment of spindle microtubules to kinetochore (GO:0008608)2.51703990
145negative regulation of interleukin-6 production (GO:0032715)2.51396461
146cellular response to exogenous dsRNA (GO:0071360)2.51079079
147pseudouridine synthesis (GO:0001522)2.49907343
1483-UTR-mediated mRNA stabilization (GO:0070935)2.44473732
149ribosome assembly (GO:0042255)2.44359855
150neutrophil activation (GO:0042119)2.43372064
151actin nucleation (GO:0045010)2.42431858
152purine nucleobase metabolic process (GO:0006144)2.41233324
153inflammatory response to antigenic stimulus (GO:0002437)2.40870898
154mitochondrial calcium ion transport (GO:0006851)2.40373489
155protoporphyrinogen IX biosynthetic process (GO:0006782)2.40282165
156antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.38257076
157necroptotic process (GO:0070266)2.38137136
158heme biosynthetic process (GO:0006783)2.37936111
159negative regulation of granulocyte differentiation (GO:0030853)2.36797283
160Golgi transport vesicle coating (GO:0048200)2.35800355
161COPI coating of Golgi vesicle (GO:0048205)2.35800355
162hydrogen peroxide metabolic process (GO:0042743)2.35400584
163anterograde synaptic vesicle transport (GO:0048490)2.35361208

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.22500076
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.81395279
3* MYB_21317192_ChIP-Seq_ERMYB_Mouse3.48498398
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.37675520
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.35505629
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.09486595
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.04225043
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.02848456
9VDR_21846776_ChIP-Seq_THP-1_Human2.90569904
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.85575810
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.79230817
12SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.70357406
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.57938285
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.53177059
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.43259768
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.39302231
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.37557198
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.37222556
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.27813475
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.24474952
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.16278762
22SPI1_23547873_ChIP-Seq_NB4_Human2.14921547
23ETS1_20019798_ChIP-Seq_JURKAT_Human2.14836552
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.09194283
25FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.05864332
26TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.05156577
27CREB1_15753290_ChIP-ChIP_HEK293T_Human1.99011037
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.94462259
29IRF8_21731497_ChIP-ChIP_J774_Mouse1.93623580
30VDR_24763502_ChIP-Seq_THP-1_Human1.93445818
31SCL_19346495_ChIP-Seq_HPC-7_Human1.91542168
32BRD4_27068464_Chip-Seq_AML-cells_Mouse1.89507320
33VDR_23849224_ChIP-Seq_CD4+_Human1.89162280
34HOXB4_20404135_ChIP-ChIP_EML_Mouse1.86866263
35SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.85839275
36FOXP3_21729870_ChIP-Seq_TREG_Human1.84917816
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.84079800
38MYC_22102868_ChIP-Seq_BL_Human1.81724639
39VDR_24787735_ChIP-Seq_THP-1_Human1.81585855
40SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.80264395
41* SPI1_23127762_ChIP-Seq_K562_Human1.79196288
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.78085993
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.76790384
44ERG_20887958_ChIP-Seq_HPC-7_Mouse1.74017589
45MYC_19079543_ChIP-ChIP_MESCs_Mouse1.73631419
46GATA1_19941826_ChIP-Seq_K562_Human1.73387945
47XRN2_22483619_ChIP-Seq_HELA_Human1.72374507
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.58626241
49GATA1_22025678_ChIP-Seq_K562_Human1.58389963
50NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57608951
51DCP1A_22483619_ChIP-Seq_HELA_Human1.57452605
52IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.56972270
53CIITA_25753668_ChIP-Seq_RAJI_Human1.56026531
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.55257355
55RUNX1_22412390_ChIP-Seq_EML_Mouse1.54824698
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.54555887
57SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53520370
58NELFA_20434984_ChIP-Seq_ESCs_Mouse1.52456461
59GABP_19822575_ChIP-Seq_HepG2_Human1.44939151
60AR_21909140_ChIP-Seq_LNCAP_Human1.44014816
61GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.43435907
62PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43205290
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.42107017
64GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.41856328
65MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.40086340
66E2F1_18555785_ChIP-Seq_MESCs_Mouse1.39553936
67STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.39276635
68HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.38464748
69BP1_19119308_ChIP-ChIP_Hs578T_Human1.38218170
70THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37260212
71* NCOR1_26117541_ChIP-Seq_K562_Human1.36885742
72MYB_26560356_Chip-Seq_TH2_Human1.36492029
73STAT4_19710469_ChIP-ChIP_TH1__Mouse1.35756313
74TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34798831
75GATA1_22383799_ChIP-Seq_G1ME_Mouse1.34326322
76KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31447818
77GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.30954292
78GATA1_19941827_ChIP-Seq_MEL_Mouse1.30339365
79TTF2_22483619_ChIP-Seq_HELA_Human1.29940625
80GATA2_19941826_ChIP-Seq_K562_Human1.28721507
81ELK1_19687146_ChIP-ChIP_HELA_Human1.27612970
82GATA3_27048872_Chip-Seq_THYMUS_Human1.27561966
83MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.26923694
84E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.26581922
85IRF8_22096565_ChIP-ChIP_GC-B_Human1.25006875
86CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.24401465
87MAF_26560356_Chip-Seq_TH2_Human1.24295014
88FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.23927584
89TCF7_22412390_ChIP-Seq_EML_Mouse1.23748443
90MYCN_18555785_ChIP-Seq_MESCs_Mouse1.23462083
91VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22709335
92CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.21955646
93FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.18984897
94UTX_26944678_Chip-Seq_JUKART_Human1.18618239
95RUNX_20019798_ChIP-Seq_JUKART_Human1.18029771
96E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17329087
97PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17212705
98LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.16645920
99ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16102745
100MYB_26560356_Chip-Seq_TH1_Human1.15772281
101Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.14458432
102GATA3_26560356_Chip-Seq_TH2_Human1.14353536
103IRF8_27001747_Chip-Seq_BMDM_Mouse1.13773836
104GATA2_22383799_ChIP-Seq_G1ME_Mouse1.13591842
105ETS1_22383799_ChIP-Seq_G1ME_Mouse1.13476107
106CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13460830
107* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12419712
108MAF_26560356_Chip-Seq_TH1_Human1.11450499
109RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10429189
110LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.07807183
111STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.06312936
112STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.03878183
113POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.03202606
114PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.01775810
115TFEB_21752829_ChIP-Seq_HELA_Human1.01511553
116SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01246027
117CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.00391990
118PU_27001747_Chip-Seq_BMDM_Mouse0.99495456
119PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97955780
120MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.97730463
121KDM5A_27292631_Chip-Seq_BREAST_Human0.97354884
122ELF1_20517297_ChIP-Seq_JURKAT_Human0.94828046
123YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94619984
124CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94466514
125CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.93429020
126SPI1_20517297_ChIP-Seq_HL60_Human0.93202515
127CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92454178
128CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91489055
129PU.1_20513432_ChIP-Seq_Bcells_Mouse0.91436301
130KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.90230278
131FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88867378
132PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.88457620

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.07374112
2MP0002396_abnormal_hematopoietic_system4.05066534
3MP0003303_peritoneal_inflammation3.38644423
4MP0003436_decreased_susceptibility_to3.21568536
5MP0003183_abnormal_peptide_metabolism3.06271467
6MP0010094_abnormal_chromosome_stability2.97026892
7MP0008057_abnormal_DNA_replication2.92263988
8MP0009785_altered_susceptibility_to2.90737762
9MP0003172_abnormal_lysosome_physiology2.90308778
10MP0002419_abnormal_innate_immunity2.88825406
11MP0009278_abnormal_bone_marrow2.79165524
12MP0003111_abnormal_nucleus_morphology2.68920522
13MP0003724_increased_susceptibility_to2.62107775
14MP0005174_abnormal_tail_pigmentation2.52501451
15MP0005464_abnormal_platelet_physiology2.42033927
16MP0000490_abnormal_crypts_of2.40201153
17MP0005083_abnormal_biliary_tract2.40144735
18MP0000569_abnormal_digit_pigmentation2.39835979
19MP0005025_abnormal_response_to2.39345787
20MP0001835_abnormal_antigen_presentation2.38082258
21MP0002166_altered_tumor_susceptibility2.38053603
22MP0004957_abnormal_blastocyst_morpholog2.36780678
23MP0003077_abnormal_cell_cycle2.28805131
24MP0000465_gastrointestinal_hemorrhage2.23291120
25MP0002148_abnormal_hypersensitivity_rea2.16852280
26MP0008058_abnormal_DNA_repair1.98809764
27MP0002420_abnormal_adaptive_immunity1.93513488
28MP0005000_abnormal_immune_tolerance1.91523027
29MP0005075_abnormal_melanosome_morpholog1.91063593
30MP0006082_CNS_inflammation1.89687690
31MP0001819_abnormal_immune_cell1.88919495
32MP0002006_tumorigenesis1.85917071
33MP0005397_hematopoietic_system_phenotyp1.85419365
34MP0001545_abnormal_hematopoietic_system1.85419365
35MP0000858_altered_metastatic_potential1.81488488
36MP0000015_abnormal_ear_pigmentation1.78738031
37MP0004808_abnormal_hematopoietic_stem1.77802332
38MP0006054_spinal_hemorrhage1.75269182
39MP0001853_heart_inflammation1.74756526
40MP0002398_abnormal_bone_marrow1.72140293
41MP0009333_abnormal_splenocyte_physiolog1.67558319
42MP0000716_abnormal_immune_system1.63461022
43MP0001533_abnormal_skeleton_physiology1.60270473
44MP0002452_abnormal_antigen_presenting1.55019718
45MP0001845_abnormal_inflammatory_respons1.53649558
46MP0002722_abnormal_immune_system1.53220569
47MP0002429_abnormal_blood_cell1.53065810
48MP0003186_abnormal_redox_activity1.51899570
49MP0002723_abnormal_immune_serum1.51060796
50MP0010307_abnormal_tumor_latency1.48435026
51MP0002095_abnormal_skin_pigmentation1.47932435
52MP0005671_abnormal_response_to1.47448092
53MP0001986_abnormal_taste_sensitivity1.45789682
54MP0000689_abnormal_spleen_morphology1.44073772
55MP0003763_abnormal_thymus_physiology1.43215459
56MP0008995_early_reproductive_senescence1.40204286
57MP0002405_respiratory_system_inflammati1.39552444
58MP0002019_abnormal_tumor_incidence1.38528837
59MP0001800_abnormal_humoral_immune1.38523746
60MP0008007_abnormal_cellular_replicative1.38310480
61MP0010155_abnormal_intestine_physiology1.37386337
62MP0009764_decreased_sensitivity_to1.35690971
63MP0003828_pulmonary_edema1.32309863
64MP0005076_abnormal_cell_differentiation1.32065756
65MP0009379_abnormal_foot_pigmentation1.30759364
66MP0000343_altered_response_to1.28163369
67MP0005360_urolithiasis1.27172279
68MP0003656_abnormal_erythrocyte_physiolo1.26431835
69MP0001663_abnormal_digestive_system1.26225884
70MP0003191_abnormal_cellular_cholesterol1.26061530
71MP0004185_abnormal_adipocyte_glucose1.24757968
72MP0003806_abnormal_nucleotide_metabolis1.23074978
73MP0008961_abnormal_basal_metabolism1.21953518
74MP0003866_abnormal_defecation1.20487205
75MP0005058_abnormal_lysosome_morphology1.19365117
76MP0000685_abnormal_immune_system1.17410138
77MP0003221_abnormal_cardiomyocyte_apopto1.15379500
78MP0002132_abnormal_respiratory_system1.14448729
79MP0004782_abnormal_surfactant_physiolog1.14309582
80MP0002877_abnormal_melanocyte_morpholog1.09037068
81MP0006036_abnormal_mitochondrial_physio1.08767580
82MP0008260_abnormal_autophagy1.08397310
83MP0001764_abnormal_homeostasis1.06867140
84MP0000703_abnormal_thymus_morphology1.06325283
85MP0005409_darkened_coat_color1.05095554
86MP0001873_stomach_inflammation1.04819548
87MP0003786_premature_aging1.03501280
88MP0008469_abnormal_protein_level1.02563784
89MP0004264_abnormal_extraembryonic_tissu1.01619152
90MP0004947_skin_inflammation1.01433204
91MP0001851_eye_inflammation1.00748109
92MP0000350_abnormal_cell_proliferation1.00031636
93MP0000313_abnormal_cell_death0.98839495
94MP0008932_abnormal_embryonic_tissue0.98573830
95MP0008873_increased_physiological_sensi0.95952406
96MP0005164_abnormal_response_to0.91429725
97MP0005319_abnormal_enzyme/_coenzyme0.91308048
98MP0009765_abnormal_xenobiotic_induced0.89804627
99MP0000598_abnormal_liver_morphology0.89615885
100MP0000358_abnormal_cell_content/0.88539183
101MP0003075_altered_response_to0.88464172
102MP0003638_abnormal_response/metabolism_0.81812527
103MP0000249_abnormal_blood_vessel0.79712880
104MP0002735_abnormal_chemical_nociception0.79387242
105MP0001790_abnormal_immune_system0.79324821
106MP0005387_immune_system_phenotype0.79324821
107MP0009115_abnormal_fat_cell0.76827345
108MP0000681_abnormal_thyroid_gland0.75513623
109MP0002971_abnormal_brown_adipose0.73508127
110MP0009763_increased_sensitivity_to0.72354362
111MP0004883_abnormal_blood_vessel0.70632704
112MP0001730_embryonic_growth_arrest0.69850025
113MP0005220_abnormal_exocrine_pancreas0.69220914
114MP0003300_gastrointestinal_ulcer0.68902649
115MP0002998_abnormal_bone_remodeling0.68558765
116MP0005266_abnormal_metabolism0.68430420
117MP0003123_paternal_imprinting0.68322815
118MP0005408_hypopigmentation0.66985308
119MP0004134_abnormal_chest_morphology0.66951323
120MP0005381_digestive/alimentary_phenotyp0.66473141
121MP0005376_homeostasis/metabolism_phenot0.65049865
122MP0005384_cellular_phenotype0.63538173
123MP0000371_diluted_coat_color0.61910894
124MP0002009_preneoplasia0.61549754
125MP0004147_increased_porphyrin_level0.60775076
126MP0002089_abnormal_postnatal_growth/wei0.58462682
127MP0002970_abnormal_white_adipose0.58143429
128MP0005621_abnormal_cell_physiology0.56546835
129MP0002080_prenatal_lethality0.56401968

Predicted human phenotypes

RankGene SetZ-score
1Thrombocytosis (HP:0001894)7.63290929
2Abnormality of the heme biosynthetic pathway (HP:0010472)5.92502611
3Obstructive lung disease (HP:0006536)5.35643737
4Chronic obstructive pulmonary disease (HP:0006510)5.35643737
5Abnormality of the prostate (HP:0008775)4.94726648
6Hypochromic microcytic anemia (HP:0004840)4.90274370
7Recurrent abscess formation (HP:0002722)4.74761118
8Reduced antithrombin III activity (HP:0001976)4.67114207
9Eczematoid dermatitis (HP:0000976)4.52632902
10Amyloidosis (HP:0011034)4.50496929
11Recurrent bacterial skin infections (HP:0005406)4.42642443
12Periodontitis (HP:0000704)4.21619611
13Type I transferrin isoform profile (HP:0003642)4.16373273
14Chest pain (HP:0100749)3.97083517
15Abnormal number of erythroid precursors (HP:0012131)3.82851583
16Eosinophilia (HP:0001880)3.81321370
17Reticulocytopenia (HP:0001896)3.80727332
18Abnormality of cells of the erythroid lineage (HP:0012130)3.64861297
19Granulocytopenia (HP:0001913)3.63959432
20Elevated erythrocyte sedimentation rate (HP:0003565)3.61452725
21Acute lymphatic leukemia (HP:0006721)3.48569781
22Prolonged bleeding time (HP:0003010)3.45471061
23Abnormal delayed hypersensitivity skin test (HP:0002963)3.44126435
24Myositis (HP:0100614)3.40005009
25Aplastic anemia (HP:0001915)3.39658171
26Ureteral stenosis (HP:0000071)3.38885511
27Chronic mucocutaneous candidiasis (HP:0002728)3.34294795
28Recurrent cutaneous fungal infections (HP:0011370)3.34294795
29Meningitis (HP:0001287)3.34132267
30Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.31551690
31Abnormal protein N-linked glycosylation (HP:0012347)3.31551690
32Abnormal protein glycosylation (HP:0012346)3.31551690
33Abnormal glycosylation (HP:0012345)3.31551690
34Papilledema (HP:0001085)3.28607692
35Pulmonary fibrosis (HP:0002206)3.22843118
36Recurrent gram-negative bacterial infections (HP:0005420)3.21356674
37Abnormality of B cell number (HP:0010975)3.07611532
38B lymphocytopenia (HP:0010976)3.07611532
39Hypochromic anemia (HP:0001931)3.06797019
40Petechiae (HP:0000967)3.05693007
41Microcytic anemia (HP:0001935)3.03654301
42Gangrene (HP:0100758)3.00345408
43IgM deficiency (HP:0002850)2.96649623
44Ureteral obstruction (HP:0006000)2.96441167
45Poikilocytosis (HP:0004447)2.95262536
46Hepatosplenomegaly (HP:0001433)2.92548605
47Poikiloderma (HP:0001029)2.92528516
48Abnormal hemoglobin (HP:0011902)2.91311053
49Autoimmune thrombocytopenia (HP:0001973)2.88659195
50Hemoptysis (HP:0002105)2.85354470
51Polycythemia (HP:0001901)2.79050398
52Mediastinal lymphadenopathy (HP:0100721)2.76931398
53Pulmonary infiltrates (HP:0002113)2.76839653
54Abnormality of iron homeostasis (HP:0011031)2.74122969
55Chromsome breakage (HP:0040012)2.73085981
56Abnormality of the pleura (HP:0002103)2.69743388
57Abnormality of eosinophils (HP:0001879)2.69552349
58Neutropenia (HP:0001875)2.68671190
59Hypergammaglobulinemia (HP:0010702)2.64972336
60Increased neuronal autofluorescent lipopigment (HP:0002074)2.63183036
61Abnormality of T cell physiology (HP:0011840)2.61722996
62Recurrent skin infections (HP:0001581)2.60506592
63Epistaxis (HP:0000421)2.54719095
64Increased serum ferritin (HP:0003281)2.53354192
65Leukocytosis (HP:0001974)2.51971845
66Panhypogammaglobulinemia (HP:0003139)2.50835058
67Gingival bleeding (HP:0000225)2.48722397
68Abnormality of the thoracic spine (HP:0100711)2.47996046
69Abnormality of transition element cation homeostasis (HP:0011030)2.47776082
70Chromosomal breakage induced by crosslinking agents (HP:0003221)2.47611266
71Paralysis (HP:0003470)2.45760659
72Abnormality of macrophages (HP:0004311)2.44790032
73Abnormality of DNA repair (HP:0003254)2.40297446
74Chronic otitis media (HP:0000389)2.39842659
75Abnormality of male internal genitalia (HP:0000022)2.39662194
76Entropion (HP:0000621)2.37916358
77Vasculitis (HP:0002633)2.37621754
78Pallor (HP:0000980)2.35859014
79Thoracic kyphosis (HP:0002942)2.35564156
80Increased cerebral lipofuscin (HP:0011813)2.33434580
81Duplicated collecting system (HP:0000081)2.30038935
82J-shaped sella turcica (HP:0002680)2.29756304
83Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.29435066
84Skin ulcer (HP:0200042)2.27944664
85Agammaglobulinemia (HP:0004432)2.26285176
86Oral leukoplakia (HP:0002745)2.24161726
87Sepsis (HP:0100806)2.22183735
88Paresthesia (HP:0003401)2.21432197
89Bone marrow hypocellularity (HP:0005528)2.19963166
90Cellulitis (HP:0100658)2.19316479
91Gingivitis (HP:0000230)2.17732476
92Thrombophlebitis (HP:0004418)2.15767038
93Glomerulopathy (HP:0100820)2.15184679
94Recurrent fungal infections (HP:0002841)2.15080548
95Fatigue (HP:0012378)2.14187912
96Reticulocytosis (HP:0001923)2.13878229
97Myelodysplasia (HP:0002863)2.13862974
98Autoimmune hemolytic anemia (HP:0001890)2.12681852
99Restrictive lung disease (HP:0002091)2.12168975
100Cutaneous melanoma (HP:0012056)2.10930937
101Spondylolisthesis (HP:0003302)2.10043841
102Agnosia (HP:0010524)2.08406196
103Amaurosis fugax (HP:0100576)2.06458978
104Pancytopenia (HP:0001876)2.05731177
105Abnormality of the anterior horn cell (HP:0006802)2.05513208
106Degeneration of anterior horn cells (HP:0002398)2.05513208
107Encephalitis (HP:0002383)2.05274499
108Neurodegeneration (HP:0002180)2.05099551
109Vacuolated lymphocytes (HP:0001922)2.04223955
110Dysostosis multiplex (HP:0000943)2.02988222
111Severe visual impairment (HP:0001141)2.01777746
112Abnormality of T cells (HP:0002843)2.00727151
113Pulmonary embolism (HP:0002204)2.00106277
114Cholelithiasis (HP:0001081)1.99923512
115Abnormality of glycolipid metabolism (HP:0010969)1.99172206
116Abnormality of liposaccharide metabolism (HP:0010968)1.99172206
117Abnormality of glycosphingolipid metabolism (HP:0004343)1.99172206
118Polyneuropathy (HP:0001271)1.97275569
119Abnormality of the renal collecting system (HP:0004742)1.96636000
120Gastrointestinal infarctions (HP:0005244)1.96505225
121Skin rash (HP:0000988)1.96072822
122Osteomyelitis (HP:0002754)1.95214459
123Recurrent viral infections (HP:0004429)1.95191030
124Arterial thrombosis (HP:0004420)1.94532039
125Abnormality of chromosome stability (HP:0003220)1.94047430
126Cutaneous photosensitivity (HP:0000992)1.93992485
127Orchitis (HP:0100796)1.92458458
128Abnormality of reticulocytes (HP:0004312)1.90788365
129Abnormal platelet function (HP:0011869)1.89519493
130Impaired platelet aggregation (HP:0003540)1.89519493
131Episodic fever (HP:0001954)1.88112667
132Generalized aminoaciduria (HP:0002909)1.87636475
133Abnormality of pyrimidine metabolism (HP:0004353)1.86987988
134Hepatic necrosis (HP:0002605)1.86667126
13511 pairs of ribs (HP:0000878)1.85958000
136Ocular albinism (HP:0001107)1.84509743
137Stomatitis (HP:0010280)1.83448111
138Acute myeloid leukemia (HP:0004808)1.82643075
139Macrocytic anemia (HP:0001972)1.80180455
140Premature graying of hair (HP:0002216)1.79474969
141Urticaria (HP:0001025)1.76120443
142Spinal canal stenosis (HP:0003416)1.73331307
143Abnormality of the lumbar spine (HP:0100712)1.72154743

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK34.71257196
2STK164.20515590
3IRAK43.76766797
4MAP3K122.83614699
5WEE12.81277272
6BUB12.67468844
7TESK12.56651065
8TEC2.47241929
9CDC72.38684766
10TESK22.36036537
11TAOK32.23893700
12PRPF4B2.15560402
13FES2.12919176
14BLK2.10168230
15BTK1.98230140
16VRK11.98054987
17MAP2K31.82571570
18PIM21.81325440
19BMPR21.76514504
20BRSK21.59112683
21TNK21.58650078
22ERN11.53556982
23LIMK11.52056739
24EIF2AK11.44993788
25SCYL21.42431729
26EEF2K1.38617258
27CDK61.38125667
28SRPK11.37618904
29MAP4K11.35518187
30EIF2AK21.34773937
31CAMKK21.30143793
32NEK21.23738468
33PKN21.19721589
34CLK11.19574726
35PAK41.19174449
36TBK11.18862300
37ATR1.17535091
38RPS6KA41.17252576
39IRAK31.16515246
40DAPK11.16035556
41MAP3K61.15597506
42MKNK11.13537916
43SYK1.12675845
44TNIK1.11447335
45KIT1.08654080
46RIPK41.08350774
47GRK61.07990291
48TSSK61.05364812
49CDK71.04688994
50FLT31.02597185
51MYLK1.00823806
52CCNB11.00239124
53CDK120.95704174
54MKNK20.94661985
55CAMK1D0.91353821
56BRSK10.89571425
57HIPK20.89462185
58MAPK40.89250375
59ABL20.89088102
60MAP3K80.87647044
61ZAP700.86942867
62JAK20.85313793
63CDK80.83712017
64RPS6KB20.82971641
65MAP2K40.82304801
66RPS6KL10.81161459
67RPS6KC10.81161459
68TRPM70.80978919
69PLK40.80434968
70ITK0.79738716
71PLK10.76708290
72RPS6KA60.76500254
73CDK40.75715655
74IKBKE0.75374584
75PIM10.75309008
76AURKB0.75244076
77NEK10.74063761
78ILK0.71861561
79LCK0.71606117
80MOS0.70623978
81ACVR1B0.70002603
82PDK10.68009071
83LYN0.67863264
84TAOK10.67805150
85LRRK20.67636249
86IKBKB0.67315373
87JAK30.67038281
88BCKDK0.65847658
89VRK20.65722100
90CAMK1G0.64684395
91MAP3K140.64644098
92TTK0.63949413
93RPS6KA20.63899488
94KDR0.63117812
95MAP2K20.62831200
96STK40.62696316
97EPHB10.62631570
98MARK30.62490798
99NME20.61018206
100MAP3K50.60727026
101YES10.60200229
102MAP3K110.59342157
103NUAK10.58987334
104PDPK10.58519873
105PIK3CG0.58519513
106MAPKAPK50.58076141
107RPS6KA50.56201814
108CDK190.56173170
109RPS6KB10.55238770
110PASK0.55207987
111TYK20.53926320
112CSK0.53841632
113TRIB30.52091962
114TXK0.50043585
115GRK70.50033890
116MAP2K60.49554904
117HCK0.49396566
118RAF10.49088374
119ABL10.48005197
120MAPK120.47361021
121BRD40.44690283
122PLK30.44483417
123MAP3K10.44328454
124PAK10.44240787
125MAP4K20.44016246
126TAOK20.43659872
127STK100.43521530
128GSK3A0.43230325
129MATK0.42767080
130CHEK20.41517844
131PRKCD0.39292441
132CHEK10.39065119
133MAPKAPK30.38593125
134CSNK2A20.38398048
135MAPK150.38016604
136PRKCQ0.37583980
137TGFBR10.37542210
138MAP3K70.37257251
139CSF1R0.37075957
140MAPKAPK20.36986209
141AURKA0.36745913

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.18058913
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.67486097
3Mismatch repair_Homo sapiens_hsa034303.30598322
4Protein export_Homo sapiens_hsa030603.18056794
5Ribosome_Homo sapiens_hsa030102.95658699
6Base excision repair_Homo sapiens_hsa034102.94654017
7Homologous recombination_Homo sapiens_hsa034402.77416852
8N-Glycan biosynthesis_Homo sapiens_hsa005102.69332639
9Pentose phosphate pathway_Homo sapiens_hsa000302.46296095
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.26735383
11Renin-angiotensin system_Homo sapiens_hsa046142.20385569
12Nucleotide excision repair_Homo sapiens_hsa034202.10169900
13Non-homologous end-joining_Homo sapiens_hsa034501.96467447
14Spliceosome_Homo sapiens_hsa030401.90205028
15Proteasome_Homo sapiens_hsa030501.89625566
16Malaria_Homo sapiens_hsa051441.88816535
17Fanconi anemia pathway_Homo sapiens_hsa034601.87959686
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.80007943
19Acute myeloid leukemia_Homo sapiens_hsa052211.75608043
20Leishmaniasis_Homo sapiens_hsa051401.73357069
21One carbon pool by folate_Homo sapiens_hsa006701.73233265
22Pyrimidine metabolism_Homo sapiens_hsa002401.72035781
23Other glycan degradation_Homo sapiens_hsa005111.71341902
24Hematopoietic cell lineage_Homo sapiens_hsa046401.64370605
25Cell cycle_Homo sapiens_hsa041101.62992885
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.58352020
27Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.45940835
28Galactose metabolism_Homo sapiens_hsa000521.44374741
29RNA transport_Homo sapiens_hsa030131.43948709
30Glutathione metabolism_Homo sapiens_hsa004801.40570699
31Staphylococcus aureus infection_Homo sapiens_hsa051501.40489178
32Glycosaminoglycan degradation_Homo sapiens_hsa005311.38859615
33RNA polymerase_Homo sapiens_hsa030201.32999917
34SNARE interactions in vesicular transport_Homo sapiens_hsa041301.25504016
35Non-small cell lung cancer_Homo sapiens_hsa052231.23090058
36Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.18760444
37RNA degradation_Homo sapiens_hsa030181.14882172
38Antigen processing and presentation_Homo sapiens_hsa046121.14642402
39African trypanosomiasis_Homo sapiens_hsa051431.11843037
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11341107
41Phagosome_Homo sapiens_hsa041451.09916614
42Systemic lupus erythematosus_Homo sapiens_hsa053221.09476781
43Starch and sucrose metabolism_Homo sapiens_hsa005001.06874642
44Amoebiasis_Homo sapiens_hsa051461.05813616
45Asthma_Homo sapiens_hsa053101.05291385
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.03895199
47Pancreatic cancer_Homo sapiens_hsa052121.03005982
48Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.02260982
49Purine metabolism_Homo sapiens_hsa002301.00614063
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97039917
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94990500
52Glycerophospholipid metabolism_Homo sapiens_hsa005640.92156647
53Chronic myeloid leukemia_Homo sapiens_hsa052200.90903786
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88477387
55Biosynthesis of amino acids_Homo sapiens_hsa012300.87756456
56Fructose and mannose metabolism_Homo sapiens_hsa000510.87728262
57Legionellosis_Homo sapiens_hsa051340.86236110
58Carbon metabolism_Homo sapiens_hsa012000.85132896
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.82519124
60Herpes simplex infection_Homo sapiens_hsa051680.79902779
61Lysosome_Homo sapiens_hsa041420.79429394
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76281896
63Jak-STAT signaling pathway_Homo sapiens_hsa046300.75299005
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.73575081
65Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.73307996
66NOD-like receptor signaling pathway_Homo sapiens_hsa046210.71569004
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71133958
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70703684
69Basal transcription factors_Homo sapiens_hsa030220.68684156
70p53 signaling pathway_Homo sapiens_hsa041150.68316002
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67297155
72Osteoclast differentiation_Homo sapiens_hsa043800.65680761
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.61362802
74Pertussis_Homo sapiens_hsa051330.61337791
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61107411
76Intestinal immune network for IgA production_Homo sapiens_hsa046720.60614731
77Nitrogen metabolism_Homo sapiens_hsa009100.59644462
78T cell receptor signaling pathway_Homo sapiens_hsa046600.59529915
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58997958
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57480778
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56098705
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55704932
83Tuberculosis_Homo sapiens_hsa051520.55271585
84Renal cell carcinoma_Homo sapiens_hsa052110.55129076
85Sulfur relay system_Homo sapiens_hsa041220.54000905
86Primary immunodeficiency_Homo sapiens_hsa053400.53452143
87Epstein-Barr virus infection_Homo sapiens_hsa051690.52810750
88Regulation of autophagy_Homo sapiens_hsa041400.52564637
89Thyroid cancer_Homo sapiens_hsa052160.52344095
90Measles_Homo sapiens_hsa051620.52214686
91Apoptosis_Homo sapiens_hsa042100.51670788
92Arachidonic acid metabolism_Homo sapiens_hsa005900.50208951
93Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50094122
94Choline metabolism in cancer_Homo sapiens_hsa052310.50048959
95VEGF signaling pathway_Homo sapiens_hsa043700.49997840
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.48316544
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.48253635
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48097092
99Selenocompound metabolism_Homo sapiens_hsa004500.47397065
100Chemokine signaling pathway_Homo sapiens_hsa040620.46371048
101Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45466567
102Histidine metabolism_Homo sapiens_hsa003400.44385386
103Shigellosis_Homo sapiens_hsa051310.44311514
104Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42330092
105B cell receptor signaling pathway_Homo sapiens_hsa046620.41182409
106Salmonella infection_Homo sapiens_hsa051320.40665110
107mRNA surveillance pathway_Homo sapiens_hsa030150.40262577
1082-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.39193278
109Influenza A_Homo sapiens_hsa051640.38341310
110Salivary secretion_Homo sapiens_hsa049700.37475762
111Metabolic pathways_Homo sapiens_hsa011000.36629556
112Vitamin B6 metabolism_Homo sapiens_hsa007500.36173524
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36147101
114Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.35684008
115Thyroid hormone synthesis_Homo sapiens_hsa049180.34870552
116Sulfur metabolism_Homo sapiens_hsa009200.34025068
117HIF-1 signaling pathway_Homo sapiens_hsa040660.33489223
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33056123
119Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32898036
120Viral carcinogenesis_Homo sapiens_hsa052030.32684904
121Platelet activation_Homo sapiens_hsa046110.32431505
122Hepatitis B_Homo sapiens_hsa051610.31830532
123Toll-like receptor signaling pathway_Homo sapiens_hsa046200.30328808
124Parkinsons disease_Homo sapiens_hsa050120.29860417
125NF-kappa B signaling pathway_Homo sapiens_hsa040640.29261610
126Cyanoamino acid metabolism_Homo sapiens_hsa004600.29227756
127ABC transporters_Homo sapiens_hsa020100.28733396
128Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28708124
129Pancreatic secretion_Homo sapiens_hsa049720.28296504
130Toxoplasmosis_Homo sapiens_hsa051450.28094212
131Neurotrophin signaling pathway_Homo sapiens_hsa047220.27899889

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