MS4A4A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features, similar intron/exon splice boundaries, and display unique expression patterns in hematopoietic cells and nonlymphoid tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)5.80923311
2positive regulation by symbiont of host defense response (GO:0052509)5.76309473
3modulation by symbiont of host defense response (GO:0052031)5.76309473
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.76309473
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.76309473
6positive regulation by organism of defense response of other organism involved in symbiotic interact5.76309473
7modulation by symbiont of host immune response (GO:0052553)5.76309473
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.49201190
9positive regulation of monocyte chemotaxis (GO:0090026)5.44193867
10regulation of dendritic cell antigen processing and presentation (GO:0002604)5.18161189
11regulation of interferon-beta biosynthetic process (GO:0045357)5.14573020
12positive regulation of interferon-alpha production (GO:0032727)5.10552566
13negative regulation of interleukin-12 production (GO:0032695)5.05441086
14eosinophil chemotaxis (GO:0048245)5.04859750
15macrophage activation involved in immune response (GO:0002281)4.99198899
16microglial cell activation (GO:0001774)4.98780539
17glycosphingolipid catabolic process (GO:0046479)4.95303610
18regulation of interferon-alpha production (GO:0032647)4.87251442
19positive regulation of cellular amide metabolic process (GO:0034250)4.83419892
20positive regulation of antigen processing and presentation (GO:0002579)4.80806404
21macrophage activation (GO:0042116)4.56686229
22cellular response to thyroid hormone stimulus (GO:0097067)4.54132253
23oligosaccharide catabolic process (GO:0009313)4.52682478
24glycolipid catabolic process (GO:0019377)4.45756293
25eosinophil migration (GO:0072677)4.44345626
26immunoglobulin mediated immune response (GO:0016064)4.39321087
27regulation of monocyte chemotaxis (GO:0090025)4.21125167
28response to peptidoglycan (GO:0032494)4.21086504
29regulation of antigen processing and presentation (GO:0002577)4.11068248
30amino sugar catabolic process (GO:0046348)4.09299927
31respiratory burst (GO:0045730)4.07776010
32regulation of mononuclear cell migration (GO:0071675)4.01939438
33granulocyte activation (GO:0036230)3.98117131
34neutrophil activation (GO:0042119)3.98089117
35ceramide catabolic process (GO:0046514)3.96679651
36pinocytosis (GO:0006907)3.94739628
37positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.89401299
38positive regulation of gamma-delta T cell activation (GO:0046645)3.80675201
39positive regulation of mast cell degranulation (GO:0043306)3.79081923
40positive regulation of mast cell activation involved in immune response (GO:0033008)3.79081923
41response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.77451379
42response to host immune response (GO:0052572)3.77451379
43regulation of B cell receptor signaling pathway (GO:0050855)3.76744483
44detection of molecule of bacterial origin (GO:0032490)3.75212660
45positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.72187892
46regulation of hypersensitivity (GO:0002883)3.70356838
47lipopolysaccharide-mediated signaling pathway (GO:0031663)3.69360094
48T-helper 1 type immune response (GO:0042088)3.68888218
49regulation of mast cell degranulation (GO:0043304)3.68511914
50myeloid cell activation involved in immune response (GO:0002275)3.68121997
51monocyte chemotaxis (GO:0002548)3.67428016
52negative regulation of mast cell activation (GO:0033004)3.64634982
53production of molecular mediator involved in inflammatory response (GO:0002532)3.64046114
54positive regulation of mast cell activation (GO:0033005)3.62010903
55cellular response to type I interferon (GO:0071357)3.61500838
56type I interferon signaling pathway (GO:0060337)3.61500838
57lymphocyte chemotaxis (GO:0048247)3.60920809
58detection of other organism (GO:0098543)3.59181233
59positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.56730471
60response to type I interferon (GO:0034340)3.54972178
61response to thyroid hormone (GO:0097066)3.52244136
62positive regulation of interferon-beta production (GO:0032728)3.49723533
63positive regulation of lymphocyte migration (GO:2000403)3.46273552
64positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.44420810
65regulation of mast cell activation involved in immune response (GO:0033006)3.42587497
66regulation of activation of Janus kinase activity (GO:0010533)3.42309618
67regulation of macrophage chemotaxis (GO:0010758)3.39857617
68N-acetylneuraminate metabolic process (GO:0006054)3.37882356
69defense response to protozoan (GO:0042832)3.37480408
70positive regulation of type 2 immune response (GO:0002830)3.30646144
71response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.30071241
72response to host (GO:0075136)3.30071241
73response to host defenses (GO:0052200)3.30071241
74phagocytosis, engulfment (GO:0006911)3.29612399
75regulation of mast cell activation (GO:0033003)3.28851872
76interferon-gamma-mediated signaling pathway (GO:0060333)3.25478714
77cellular extravasation (GO:0045123)3.25014648
78negative regulation of nitric oxide biosynthetic process (GO:0045019)3.24026170
79adhesion of symbiont to host cell (GO:0044650)3.22063693
80virion attachment to host cell (GO:0019062)3.22063693
81regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.21798583
82regulation of lymphocyte chemotaxis (GO:1901623)3.21237252
83myeloid leukocyte activation (GO:0002274)3.20849296
84detection of bacterium (GO:0016045)3.20692058
85positive regulation of macrophage differentiation (GO:0045651)3.20064991
86positive regulation of macrophage cytokine production (GO:0060907)3.18334934
87response to interferon-alpha (GO:0035455)3.17367001
88membrane lipid catabolic process (GO:0046466)3.15077527
89cellular response to interferon-alpha (GO:0035457)3.14206340
90B cell mediated immunity (GO:0019724)3.13671634
91sphingolipid catabolic process (GO:0030149)3.10713304
92positive regulation of leukocyte degranulation (GO:0043302)3.08899102
93myeloid dendritic cell differentiation (GO:0043011)3.08195526
94regulation of T-helper 2 cell differentiation (GO:0045628)3.07537869
95detection of biotic stimulus (GO:0009595)3.06450732
96positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)3.05572585
97antigen processing and presentation of endogenous antigen (GO:0019883)3.05048176
98positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.04468533
99negative regulation of interleukin-17 production (GO:0032700)3.04384319
100response to protozoan (GO:0001562)3.03602037
101positive regulation of T cell migration (GO:2000406)3.03036889
102hydrogen peroxide biosynthetic process (GO:0050665)3.02992318
103positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.00140157
104regulation of leukocyte degranulation (GO:0043300)2.98905324
105positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.96465358
106regulation of myeloid leukocyte mediated immunity (GO:0002886)2.96458239
107regulation of inflammatory response to antigenic stimulus (GO:0002861)2.93059146
108negative regulation of cytokine production involved in immune response (GO:0002719)2.90840122
109regulation of lymphocyte migration (GO:2000401)2.90343810
110negative regulation of myeloid cell apoptotic process (GO:0033033)2.88193967
111positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.87792803
112myeloid dendritic cell activation (GO:0001773)2.87439532
113adhesion of symbiont to host (GO:0044406)2.87085343
114keratan sulfate catabolic process (GO:0042340)2.86528326
115regulation of vitamin D biosynthetic process (GO:0060556)2.86325594
116T cell migration (GO:0072678)2.86128477
117regulation of cholesterol storage (GO:0010885)2.85871134
118regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.83831996
119regulation of MHC class II biosynthetic process (GO:0045346)2.83381504
120adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.82989892
121response to muramyl dipeptide (GO:0032495)2.82523611
122positive regulation of chemokine biosynthetic process (GO:0045080)2.82231510
123cellular response to interferon-gamma (GO:0071346)2.82178153
124dendritic cell chemotaxis (GO:0002407)2.81849260
125negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.81722615
126mature B cell differentiation involved in immune response (GO:0002313)2.81132470
127regulation of RIG-I signaling pathway (GO:0039535)2.80785907
128barbed-end actin filament capping (GO:0051016)2.80268142
129detection of external biotic stimulus (GO:0098581)2.78772110
130regulation of podosome assembly (GO:0071801)2.78548828
131granulocyte chemotaxis (GO:0071621)2.78519938
132regulation of cytokine secretion involved in immune response (GO:0002739)2.78122946
133positive regulation of T-helper 1 type immune response (GO:0002827)2.76776333
134positive regulation of tumor necrosis factor production (GO:0032760)2.76569313
135negative regulation of cell killing (GO:0031342)2.76081254
136negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.76081254
137positive regulation of toll-like receptor signaling pathway (GO:0034123)2.75575179
138regulation of chemokine biosynthetic process (GO:0045073)2.74908911
139positive regulation of regulated secretory pathway (GO:1903307)2.72521589
140positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.70370045
141negative regulation of erythrocyte differentiation (GO:0045647)2.69134676
142positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.67886002
143positive regulation of acute inflammatory response (GO:0002675)2.67262827
144response to interferon-gamma (GO:0034341)2.66570981
145dendritic cell differentiation (GO:0097028)2.66355500

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.98464799
2IRF8_21731497_ChIP-ChIP_J774_Mouse7.51720547
3IRF8_22096565_ChIP-ChIP_GC-B_Human6.60810098
4IRF8_27001747_Chip-Seq_BMDM_Mouse5.03139368
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.54459907
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.29402068
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.07180558
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.88081616
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.57975436
10Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.48791725
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.87601196
12* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.85427739
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.76349877
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.64461116
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.57743106
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.50076257
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.38167108
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.20602804
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.09733157
20PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse2.06577456
21PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.01703355
22VDR_24787735_ChIP-Seq_THP-1_Human2.00971205
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.92369880
24* SPI1_23547873_ChIP-Seq_NB4_Human1.91330540
25BRD4_27068464_Chip-Seq_AML-cells_Mouse1.79284583
26PU_27001747_Chip-Seq_BMDM_Mouse1.76742703
27CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.71499101
28RUNX_20019798_ChIP-Seq_JUKART_Human1.68044066
29CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.60437318
30CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.58917237
31GATA1_22025678_ChIP-Seq_K562_Human1.58337286
32CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.58097627
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.57115626
34SPI1_23127762_ChIP-Seq_K562_Human1.54547850
35SCL_19346495_ChIP-Seq_HPC-7_Human1.52022980
36EGR1_19032775_ChIP-ChIP_M12_Human1.49296275
37VDR_24763502_ChIP-Seq_THP-1_Human1.48428134
38PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.45537067
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.41684761
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.38221740
41PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36937038
42GATA2_21666600_ChIP-Seq_HMVEC_Human1.33551408
43TFEB_21752829_ChIP-Seq_HELA_Human1.31861386
44MYB_26560356_Chip-Seq_TH2_Human1.31857691
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31335618
46FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.29721374
47LXR_22292898_ChIP-Seq_THP-1_Human1.22864145
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22673303
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.21129453
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20142436
51PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17003015
52STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16462252
53LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14593072
54KDM2B_26808549_Chip-Seq_SUP-B15_Human1.14348403
55TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.13600877
56LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.13151693
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12110670
58TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11804330
59EGR1_19374776_ChIP-ChIP_THP-1_Human1.11001274
60GATA3_26560356_Chip-Seq_TH2_Human1.10446392
61STAT1_20625510_ChIP-Seq_HELA_Human1.09880977
62MAF_26560356_Chip-Seq_TH1_Human1.09062959
63RXR_22158963_ChIP-Seq_LIVER_Mouse1.08231299
64SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07817921
65IKZF1_21737484_ChIP-ChIP_HCT116_Human1.06134320
66RARG_19884340_ChIP-ChIP_MEFs_Mouse1.05248604
67ELK3_25401928_ChIP-Seq_HUVEC_Human1.03403070
68ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.01731110
69GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01260753
70PPARA_22158963_ChIP-Seq_LIVER_Mouse0.98708518
71NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96623346
72CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96182304
73MYB_26560356_Chip-Seq_TH1_Human0.93058274
74GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.90565197
75SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.89165028
76ESR1_21235772_ChIP-Seq_MCF-7_Human0.89021161
77NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.87308709
78NRF2_20460467_ChIP-Seq_MEFs_Mouse0.87308709
79CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.86935162
80GATA1_19941826_ChIP-Seq_K562_Human0.86688419
81GATA3_27048872_Chip-Seq_THYMUS_Human0.86330422
82SMAD_19615063_ChIP-ChIP_OVARY_Human0.85940980
83TCF7_22412390_ChIP-Seq_EML_Mouse0.84739721
84* SPI1_20517297_ChIP-Seq_HL60_Human0.83695060
85VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.83500877
86TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83320939
87CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.83039172
88CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.82876493
89FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.82549697
90WT1_19549856_ChIP-ChIP_CCG9911_Human0.82540353
91SOX2_20726797_ChIP-Seq_SW620_Human0.81148438
92ESR2_21235772_ChIP-Seq_MCF-7_Human0.80755652
93BCL6_27268052_Chip-Seq_Bcells_Human0.79193139
94BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78566616
95SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.78246832
96CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.77349831
97E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.77303837
98SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77064707
99MAF_26560356_Chip-Seq_TH2_Human0.76895420
100CLOCK_20551151_ChIP-Seq_293T_Human0.76409477
101CJUN_26792858_Chip-Seq_BT549_Human0.75379736
102TP63_17297297_ChIP-ChIP_HaCaT_Human0.74601261
103GATA2_22383799_ChIP-Seq_G1ME_Mouse0.74556422
104KDM2B_26808549_Chip-Seq_DND41_Human0.73848166
105BCOR_27268052_Chip-Seq_Bcells_Human0.73638239
106CDX2_20551321_ChIP-Seq_CACO-2_Human0.72946836
107SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.72031902
108VDR_21846776_ChIP-Seq_THP-1_Human0.72008549
109CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.68762261
110GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66196052
111EGR1_23403033_ChIP-Seq_LIVER_Mouse0.63141555
112GATA2_19941826_ChIP-Seq_K562_Human0.62980962
113ESR1_20079471_ChIP-ChIP_T-47D_Human0.62149481
114JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.61991572
115SMRT_27268052_Chip-Seq_Bcells_Human0.59839343
116GATA1_19941827_ChIP-Seq_MEL_Mouse0.57862809
117FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.55914989
118JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.55821236
119LXR_22158963_ChIP-Seq_LIVER_Mouse0.55570850
120PU1_27457419_Chip-Seq_LIVER_Mouse0.54864256
121RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.52337622
122PU.1_20513432_ChIP-Seq_Bcells_Mouse0.51771021
123FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.50752201
124UTX_26944678_Chip-Seq_JUKART_Human0.49695594

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.75948420
2MP0002148_abnormal_hypersensitivity_rea4.33063594
3MP0005058_abnormal_lysosome_morphology4.15479477
4MP0003436_decreased_susceptibility_to3.77972784
5MP0009840_abnormal_foam_cell3.64899152
6MP0009785_altered_susceptibility_to3.50923757
7MP0002419_abnormal_innate_immunity3.28648178
8MP0005000_abnormal_immune_tolerance3.11155919
9MP0005671_abnormal_response_to3.01509764
10MP0005025_abnormal_response_to2.92910828
11MP0003191_abnormal_cellular_cholesterol2.73432599
12MP0001790_abnormal_immune_system2.72889621
13MP0005387_immune_system_phenotype2.72889621
14MP0003724_increased_susceptibility_to2.72430471
15MP0006082_CNS_inflammation2.69051801
16MP0002452_abnormal_antigen_presenting2.58796066
17MP0003303_peritoneal_inflammation2.50371155
18MP0001800_abnormal_humoral_immune2.46227098
19MP0002723_abnormal_immune_serum2.45133702
20MP0000685_abnormal_immune_system2.34343728
21MP0002139_abnormal_hepatobiliary_system2.31182449
22MP0001533_abnormal_skeleton_physiology2.28709415
23MP0000343_altered_response_to2.26547608
24MP0000604_amyloidosis2.18271713
25MP0003690_abnormal_glial_cell2.09186580
26MP0001819_abnormal_immune_cell2.07196060
27MP0009764_decreased_sensitivity_to2.07057169
28MP0002420_abnormal_adaptive_immunity2.04674930
29MP0004510_myositis2.02312446
30MP0002405_respiratory_system_inflammati2.01917755
31MP0003075_altered_response_to1.97308927
32MP0002277_abnormal_respiratory_mucosa1.92550553
33MP0005464_abnormal_platelet_physiology1.85591051
34MP0001845_abnormal_inflammatory_respons1.80670005
35MP0001853_heart_inflammation1.79625194
36MP0003172_abnormal_lysosome_physiology1.77068651
37MP0002254_reproductive_system_inflammat1.72939339
38MP0008469_abnormal_protein_level1.71086133
39MP0003448_altered_tumor_morphology1.69091702
40MP0005310_abnormal_salivary_gland1.60678817
41MP0008004_abnormal_stomach_pH1.54695881
42MP0002998_abnormal_bone_remodeling1.52876212
43MP0003828_pulmonary_edema1.51671546
44MP0003806_abnormal_nucleotide_metabolis1.51614006
45MP0008438_abnormal_cutaneous_collagen1.48522139
46MP0000716_abnormal_immune_system1.39030050
47MP0010155_abnormal_intestine_physiology1.37795194
48MP0004947_skin_inflammation1.36991320
49MP0004782_abnormal_surfactant_physiolog1.36468410
50MP0000569_abnormal_digit_pigmentation1.35360704
51MP0005166_decreased_susceptibility_to1.31132244
52MP0005167_abnormal_blood-brain_barrier1.29745069
53MP0005451_abnormal_body_composition1.29677505
54MP0005164_abnormal_response_to1.27113206
55MP0009333_abnormal_splenocyte_physiolog1.25359737
56MP0006054_spinal_hemorrhage1.24600946
57MP0002638_abnormal_pupillary_reflex1.22864990
58MP0003329_amyloid_beta_deposits1.20807258
59MP0002398_abnormal_bone_marrow1.16202400
60MP0005365_abnormal_bile_salt1.14033630
61MP0000689_abnormal_spleen_morphology1.12503581
62MP0003279_aneurysm1.11013743
63MP0002006_tumorigenesis1.09914592
64MP0004883_abnormal_blood_vessel1.08121219
65MP0002429_abnormal_blood_cell1.07853128
66MP0003453_abnormal_keratinocyte_physiol1.05846490
67MP0003656_abnormal_erythrocyte_physiolo1.05551004
68MP0005390_skeleton_phenotype1.02164293
69MP0008260_abnormal_autophagy1.00734359
70MP0002166_altered_tumor_susceptibility0.96195376
71MP0001542_abnormal_bone_strength0.96000851
72MP0002138_abnormal_hepatobiliary_system0.95843067
73MP0000858_altered_metastatic_potential0.95113683
74MP0005174_abnormal_tail_pigmentation0.94690952
75MP0002722_abnormal_immune_system0.93829852
76MP0000015_abnormal_ear_pigmentation0.92442154
77MP0000249_abnormal_blood_vessel0.92325315
78MP0000920_abnormal_myelination0.90095300
79MP0009763_increased_sensitivity_to0.87074076
80MP0000465_gastrointestinal_hemorrhage0.84705636
81MP0002295_abnormal_pulmonary_circulatio0.80843299
82MP0002877_abnormal_melanocyte_morpholog0.77391789
83MP0005647_abnormal_sex_gland0.75949958
84MP0003795_abnormal_bone_structure0.75590658
85MP0003186_abnormal_redox_activity0.75248302
86MP0010307_abnormal_tumor_latency0.72403731
87MP0002136_abnormal_kidney_physiology0.72183764
88MP0003300_gastrointestinal_ulcer0.70940949
89MP0002933_joint_inflammation0.70640740
90MP0003705_abnormal_hypodermis_morpholog0.70430994
91MP0009278_abnormal_bone_marrow0.70019937
92MP0001663_abnormal_digestive_system0.68462381
93MP0003183_abnormal_peptide_metabolism0.67323427
94MP0002332_abnormal_exercise_endurance0.67092925
95MP0003091_abnormal_cell_migration0.66330600
96MP0003195_calcinosis0.65019121
97MP0001727_abnormal_embryo_implantation0.63097622
98MP0000767_abnormal_smooth_muscle0.62122505
99MP0005165_increased_susceptibility_to0.61795485
100MP0003634_abnormal_glial_cell0.61664705
101MP0005257_abnormal_intraocular_pressure0.61339578
102MP0005275_abnormal_skin_tensile0.61278624
103MP0005584_abnormal_enzyme/coenzyme_acti0.60689532
104MP0005319_abnormal_enzyme/_coenzyme0.60329830
105MP0009765_abnormal_xenobiotic_induced0.58441861
106MP0008874_decreased_physiological_sensi0.56779126
107MP0004019_abnormal_vitamin_homeostasis0.55013919
108MP0000609_abnormal_liver_physiology0.54862981
109MP0003566_abnormal_cell_adhesion0.54722879
110MP0003633_abnormal_nervous_system0.54446802
111MP0008873_increased_physiological_sensi0.53900871
112MP0005595_abnormal_vascular_smooth0.53612112
113MP0009115_abnormal_fat_cell0.53497007
114MP0000371_diluted_coat_color0.51597918
115MP0005397_hematopoietic_system_phenotyp0.51565136
116MP0001545_abnormal_hematopoietic_system0.51565136
117MP0010368_abnormal_lymphatic_system0.49971712
118MP0005670_abnormal_white_adipose0.49898316
119MP0001851_eye_inflammation0.49808776
120MP0005076_abnormal_cell_differentiation0.49007070
121MP0003045_fibrosis0.48461581
122MP0002090_abnormal_vision0.48223682

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)7.50155254
2Recurrent abscess formation (HP:0002722)7.47991195
3Recurrent bacterial skin infections (HP:0005406)6.82124837
4Eczematoid dermatitis (HP:0000976)5.84674344
5Glomerulonephritis (HP:0000099)5.82738727
6Recurrent gram-negative bacterial infections (HP:0005420)5.02602395
7Vacuolated lymphocytes (HP:0001922)4.95038674
8Increased cerebral lipofuscin (HP:0011813)4.48782136
9Autoimmune thrombocytopenia (HP:0001973)4.45305659
10Complement deficiency (HP:0004431)4.43883239
11Abnormality of macrophages (HP:0004311)4.43110738
12Increased neuronal autofluorescent lipopigment (HP:0002074)4.35497414
13Loss of speech (HP:0002371)4.35184263
14Axonal loss (HP:0003447)4.06752116
15Thick nail (HP:0001805)4.05971746
16Abnormality of complement system (HP:0005339)4.05921068
17Mutism (HP:0002300)4.04673157
18Mediastinal lymphadenopathy (HP:0100721)3.98695886
19Disinhibition (HP:0000734)3.89781695
20Prostate neoplasm (HP:0100787)3.80701850
21Recurrent skin infections (HP:0001581)3.75869160
22Gingivitis (HP:0000230)3.68414685
23Myositis (HP:0100614)3.68038096
24Dysostosis multiplex (HP:0000943)3.59357495
25Orchitis (HP:0100796)3.55497215
26Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.45082838
27Elevated erythrocyte sedimentation rate (HP:0003565)3.45030583
28Nephritis (HP:0000123)3.44247622
29Abnormality of liposaccharide metabolism (HP:0010968)3.40786815
30Abnormality of glycosphingolipid metabolism (HP:0004343)3.40786815
31Abnormality of glycolipid metabolism (HP:0010969)3.40786815
32Spontaneous hematomas (HP:0007420)3.37514597
33Pustule (HP:0200039)3.37310914
34Optic neuritis (HP:0100653)3.31242567
35Retrobulbar optic neuritis (HP:0100654)3.31242567
36Nuclear cataract (HP:0100018)3.13597988
37Agnosia (HP:0010524)3.12700231
38Stomatitis (HP:0010280)3.11194593
39Obstructive lung disease (HP:0006536)3.09629452
40Chronic obstructive pulmonary disease (HP:0006510)3.09629452
41Amyloidosis (HP:0011034)3.00733677
42Basal ganglia calcification (HP:0002135)3.00348971
43Recurrent fungal infections (HP:0002841)2.99761835
44Recurrent viral infections (HP:0004429)2.93263007
45Osteolytic defects of the phalanges of the hand (HP:0009771)2.89803628
46Osteolytic defects of the hand bones (HP:0009699)2.89803628
47Periodontitis (HP:0000704)2.89765764
48Neurofibrillary tangles (HP:0002185)2.87850713
49Increased IgM level (HP:0003496)2.87807650
50Myocardial infarction (HP:0001658)2.83293776
51Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.73713734
52Pulmonary infiltrates (HP:0002113)2.69606893
53Interstitial pulmonary disease (HP:0006530)2.61360136
54Hematochezia (HP:0002573)2.60644349
55Increased serum ferritin (HP:0003281)2.58996876
56Petechiae (HP:0000967)2.56007143
57Upper motor neuron abnormality (HP:0002127)2.53791476
58Joint hemorrhage (HP:0005261)2.51447949
59Neuronal loss in central nervous system (HP:0002529)2.51023129
60Vasculitis (HP:0002633)2.45860462
61Progressive visual loss (HP:0000529)2.45748353
62Progressive neurologic deterioration (HP:0002344)2.42876602
63Pathologic fracture (HP:0002756)2.40622616
64Cellulitis (HP:0100658)2.39079855
65Recurrent pneumonia (HP:0006532)2.36831315
66Urticaria (HP:0001025)2.34753914
67Hypergammaglobulinemia (HP:0010702)2.33157932
68Mucopolysacchariduria (HP:0008155)2.30377155
69Urinary glycosaminoglycan excretion (HP:0003541)2.30377155
70Abnormality of the vasculature of the conjunctiva (HP:0008054)2.30007959
71Leukocytosis (HP:0001974)2.26539163
72Hypokinesia (HP:0002375)2.22056659
73Thyroiditis (HP:0100646)2.21648806
74Hepatosplenomegaly (HP:0001433)2.21038536
75Keratoconjunctivitis sicca (HP:0001097)2.20365311
76Osteomyelitis (HP:0002754)2.20142690
77Personality changes (HP:0000751)2.20089494
78Bone pain (HP:0002653)2.19883426
79Hemoptysis (HP:0002105)2.18942827
80Abnormality of the prostate (HP:0008775)2.17464809
81Abnormality of iron homeostasis (HP:0011031)2.16409747
82Combined immunodeficiency (HP:0005387)2.16324980
83Polyneuropathy (HP:0001271)2.16226720
84Colitis (HP:0002583)2.15434484
85Abnormality of the periventricular white matter (HP:0002518)2.13373685
86Retinal atrophy (HP:0001105)2.12848851
87Dementia (HP:0000726)2.12137698
88Meningitis (HP:0001287)2.11949365
89Eosinophilia (HP:0001880)2.10830109
90Purpura (HP:0000979)2.09908363
91Asymmetric septal hypertrophy (HP:0001670)2.08855858
92Abnormality of mucopolysaccharide metabolism (HP:0011020)2.08275176
93Abnormality of polysaccharide metabolism (HP:0011012)2.08275176
94Abnormality of glycosaminoglycan metabolism (HP:0004371)2.08275176
95Vertebral compression fractures (HP:0002953)2.07884855
96Prolonged neonatal jaundice (HP:0006579)2.05933355
97Metaphyseal irregularity (HP:0003025)2.05822429
98Inappropriate behavior (HP:0000719)2.03690185
99Cerebral inclusion bodies (HP:0100314)2.03034243
100Poor head control (HP:0002421)2.01903568
101Conjunctival telangiectasia (HP:0000524)2.01747916
102Tetraparesis (HP:0002273)2.01103755
103Premature loss of primary teeth (HP:0006323)1.99782036
104Arterial thrombosis (HP:0004420)1.98780052
105Keratoconjunctivitis (HP:0001096)1.98736601
106Recurrent lower respiratory tract infections (HP:0002783)1.96248956
107Apathy (HP:0000741)1.94415584
108Nausea (HP:0002018)1.92329459
109Peripheral demyelination (HP:0011096)1.90431497
110Memory impairment (HP:0002354)1.88998860
111Cardiomegaly (HP:0001640)1.87990259
112Global brain atrophy (HP:0002283)1.87654566
113Increased CSF protein (HP:0002922)1.87053655
114T lymphocytopenia (HP:0005403)1.86563554
115Diminished motivation (HP:0000745)1.84411406
116Malnutrition (HP:0004395)1.83539034
117Inflammation of the large intestine (HP:0002037)1.81687233
118Spinal muscular atrophy (HP:0007269)1.81647256
119Gingival bleeding (HP:0000225)1.81143052
120Pulmonary embolism (HP:0002204)1.80982038
121Chronic mucocutaneous candidiasis (HP:0002728)1.80793915
122Recurrent cutaneous fungal infections (HP:0011370)1.80793915
123Supranuclear gaze palsy (HP:0000605)1.80649404
124Abnormality of T cell number (HP:0011839)1.78392312
125Thoracic kyphosis (HP:0002942)1.78065811
126Sepsis (HP:0100806)1.75632537
127Chronic otitis media (HP:0000389)1.74950711
128Abnormality of transition element cation homeostasis (HP:0011030)1.74378257
129Gangrene (HP:0100758)1.72951819
130Beaking of vertebral bodies (HP:0004568)1.68663212

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK5.90609384
2MAP3K144.94432221
3TYK24.23588802
4RIPK43.29679285
5TBK13.22143470
6IRAK42.93619677
7NME22.92915450
8MST42.61007398
9GRK72.55769357
10TGFBR22.51289380
11IKBKE2.38636001
12IKBKB2.37728531
13IRAK32.23681676
14TXK2.22254232
15PBK2.19610154
16JAK12.01637862
17DDR21.96777218
18TAOK21.77370531
19ZAP701.76405708
20KIT1.75533498
21ERN11.71569349
22MAP3K31.70136293
23BMPR21.69455578
24ACVR1B1.68082765
25MAP2K31.65945344
26FGR1.65614527
27EPHB11.61478416
28CSK1.55673291
29JAK31.54871536
30CLK11.54582173
31RIPK11.51600502
32MAP3K111.51109436
33MAP4K11.49353817
34CHUK1.47773075
35LYN1.46190422
36SYK1.43080393
37HCK1.41418517
38PIM21.33267599
39NEK91.29158269
40TAOK11.26580423
41STK101.25538056
42CSF1R1.23788464
43EIF2AK21.23088913
44BMX1.20457848
45BTK1.20183734
46TEC1.16116668
47JAK21.15020516
48MAP3K131.14993457
49FES1.10925425
50PDK21.10789573
51LCK1.08835235
52CDC42BPA1.06226643
53ADRBK21.01308544
54TAOK30.99934906
55MAP3K10.99436654
56MATK0.96062730
57BMPR1B0.95170048
58MOS0.95085107
59PRKCD0.91686158
60ITK0.86104338
61PIM10.84511438
62TESK20.82796523
63EGFR0.81540561
64YES10.80126161
65FGFR30.78457933
66ERBB30.73888928
67MAP3K50.72290352
68PDPK10.67709341
69TRPM70.66533445
70MAP2K60.60892772
71SCYL20.57466392
72PIK3CG0.56891240
73NUAK10.55104144
74MAPK120.54879576
75MAPKAPK20.53491127
76FGFR40.53471648
77ABL20.53087924
78MAP3K60.52646685
79ARAF0.51595761
80PRKCQ0.51468099
81DAPK20.50488004
82IGF1R0.50438107
83ABL10.49806013
84FYN0.48813580
85IRAK10.47587781
86PRPF4B0.44682430
87PLK20.44179418
88CDK60.43861237
89TESK10.43737098
90STK40.43487328
91PTK2B0.40024599
92EPHA30.39589449
93PTK60.38156727
94MARK30.37597493
95IRAK20.37437746
96GRK50.36775231
97RPS6KA20.36711415
98CAMK1G0.34636328
99TGFBR10.34545871
100PDGFRA0.33448466
101PKN10.31056242
102CAMKK20.29780062
103INSR0.29513737
104MET0.28157013
105SIK20.27512576
106GSK3A0.26879441
107RPS6KA60.25964133
108KSR20.23663234
109PRKD10.23649156
110PDGFRB0.23368938
111DMPK0.23157207
112PAK40.22855031
113PRKACG0.21663097
114GRK60.21598524
115PDK10.21100426
116CAMK1D0.21080179
117SRC0.20980913
118RPS6KL10.20964089
119RPS6KC10.20964089
120MAPK40.20460828
121CAMKK10.19605122
122HIPK20.19411859
123MAP3K120.19280746
124MAPK70.16956877
125TNK20.15866087
126PRKCG0.14874305
127MAPK30.14518308

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.89470441
2Toll-like receptor signaling pathway_Homo sapiens_hsa046202.88801351
3Lysosome_Homo sapiens_hsa041422.87384881
4Allograft rejection_Homo sapiens_hsa053302.86937049
5Leishmaniasis_Homo sapiens_hsa051402.84974873
6Graft-versus-host disease_Homo sapiens_hsa053322.71075309
7Pertussis_Homo sapiens_hsa051332.59433031
8Osteoclast differentiation_Homo sapiens_hsa043802.44440121
9Legionellosis_Homo sapiens_hsa051342.36567748
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.27662802
11Other glycan degradation_Homo sapiens_hsa005112.25821051
12Rheumatoid arthritis_Homo sapiens_hsa053232.21614676
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.17580697
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.13802359
15Malaria_Homo sapiens_hsa051442.13362779
16Tuberculosis_Homo sapiens_hsa051522.12774449
17Asthma_Homo sapiens_hsa053102.06062452
18Phagosome_Homo sapiens_hsa041451.91329432
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.88436312
20Measles_Homo sapiens_hsa051621.83698679
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.81166533
22Salmonella infection_Homo sapiens_hsa051321.80282128
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.79215324
24Type I diabetes mellitus_Homo sapiens_hsa049401.76844426
25Autoimmune thyroid disease_Homo sapiens_hsa053201.67585346
26Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.60597768
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.60523600
28Antigen processing and presentation_Homo sapiens_hsa046121.57167351
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.57008885
30Complement and coagulation cascades_Homo sapiens_hsa046101.54055686
31Influenza A_Homo sapiens_hsa051641.52916705
32Chemokine signaling pathway_Homo sapiens_hsa040621.50848264
33Toxoplasmosis_Homo sapiens_hsa051451.43560170
34Prion diseases_Homo sapiens_hsa050201.41390377
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.41272002
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.37542815
37African trypanosomiasis_Homo sapiens_hsa051431.32584607
38Herpes simplex infection_Homo sapiens_hsa051681.27874124
39B cell receptor signaling pathway_Homo sapiens_hsa046621.27821390
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.26201953
41Viral myocarditis_Homo sapiens_hsa054161.24529811
42TNF signaling pathway_Homo sapiens_hsa046681.20617434
43Hematopoietic cell lineage_Homo sapiens_hsa046401.18688637
44Apoptosis_Homo sapiens_hsa042101.15583226
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.13466105
46Primary immunodeficiency_Homo sapiens_hsa053401.08287718
47Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.05019440
48Jak-STAT signaling pathway_Homo sapiens_hsa046301.00142619
49Mineral absorption_Homo sapiens_hsa049780.99979583
50Shigellosis_Homo sapiens_hsa051310.95710802
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83343683
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83162728
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82927230
54Hepatitis C_Homo sapiens_hsa051600.81945082
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79082404
56Amoebiasis_Homo sapiens_hsa051460.78000771
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.75241589
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.71702805
59PPAR signaling pathway_Homo sapiens_hsa033200.68746510
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67216284
61Hepatitis B_Homo sapiens_hsa051610.66261071
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66223625
63Galactose metabolism_Homo sapiens_hsa000520.63794826
64Endocytosis_Homo sapiens_hsa041440.59970841
65Sphingolipid metabolism_Homo sapiens_hsa006000.58102515
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57998563
67Ether lipid metabolism_Homo sapiens_hsa005650.52868755
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52616948
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51602680
70Platelet activation_Homo sapiens_hsa046110.47135070
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46499079
72Renin-angiotensin system_Homo sapiens_hsa046140.45002368
73T cell receptor signaling pathway_Homo sapiens_hsa046600.44577207
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44042031
75Arachidonic acid metabolism_Homo sapiens_hsa005900.43790291
76Bladder cancer_Homo sapiens_hsa052190.42951326
77Collecting duct acid secretion_Homo sapiens_hsa049660.39930824
78Sulfur metabolism_Homo sapiens_hsa009200.33025514
79ABC transporters_Homo sapiens_hsa020100.31701980
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.29581371
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.29563701
82Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29307871
83Synaptic vesicle cycle_Homo sapiens_hsa047210.23547266
84Epstein-Barr virus infection_Homo sapiens_hsa051690.22648307
85VEGF signaling pathway_Homo sapiens_hsa043700.22607285
86HIF-1 signaling pathway_Homo sapiens_hsa040660.22456101
87Glutathione metabolism_Homo sapiens_hsa004800.21937593
88Prolactin signaling pathway_Homo sapiens_hsa049170.21523015
89Systemic lupus erythematosus_Homo sapiens_hsa053220.21467406
90Caffeine metabolism_Homo sapiens_hsa002320.21240412
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.20094521
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.18934546
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.18796098
94Notch signaling pathway_Homo sapiens_hsa043300.18191182
95HTLV-I infection_Homo sapiens_hsa051660.17994400
96Tryptophan metabolism_Homo sapiens_hsa003800.17070199
97Chronic myeloid leukemia_Homo sapiens_hsa052200.16968597
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.16036581
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.12614830
100Type II diabetes mellitus_Homo sapiens_hsa049300.12573433
101Pentose phosphate pathway_Homo sapiens_hsa000300.12036627
102Vibrio cholerae infection_Homo sapiens_hsa051100.11206927
103Proteoglycans in cancer_Homo sapiens_hsa052050.10624309
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.10039008
105Histidine metabolism_Homo sapiens_hsa003400.09684611
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.09589827
107Acute myeloid leukemia_Homo sapiens_hsa052210.09145985
108Renal cell carcinoma_Homo sapiens_hsa052110.08741548
109Pancreatic cancer_Homo sapiens_hsa052120.08580383
110Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.08417540
111GnRH signaling pathway_Homo sapiens_hsa049120.08316469
112Fructose and mannose metabolism_Homo sapiens_hsa000510.08022801
113Dorso-ventral axis formation_Homo sapiens_hsa043200.07403621
114Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.05315482
115MAPK signaling pathway_Homo sapiens_hsa040100.05044266
116Adherens junction_Homo sapiens_hsa045200.04000989
117Viral carcinogenesis_Homo sapiens_hsa052030.01894789

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