MS4A4E

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.20154029
2positive regulation of mast cell activation involved in immune response (GO:0033008)5.12219037
3positive regulation of mast cell degranulation (GO:0043306)5.12219037
4positive regulation of mast cell activation (GO:0033005)5.09761924
5response to peptidoglycan (GO:0032494)5.01220853
6neutrophil activation involved in immune response (GO:0002283)4.78952221
7regulation of mast cell degranulation (GO:0043304)4.61828708
8regulation of hypersensitivity (GO:0002883)4.53051017
9regulation of mast cell activation involved in immune response (GO:0033006)4.34248050
10regulation of mast cell activation (GO:0033003)4.29075551
11regulation of gamma-delta T cell activation (GO:0046643)4.23944517
12regulation of myeloid leukocyte mediated immunity (GO:0002886)4.03881868
13regulation of gamma-delta T cell differentiation (GO:0045586)4.00719696
14positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.95407555
15neutrophil mediated immunity (GO:0002446)3.84337818
16regulation of leukocyte degranulation (GO:0043300)3.81391919
17regulation of B cell receptor signaling pathway (GO:0050855)3.77916629
18negative regulation of interleukin-8 production (GO:0032717)3.76421573
19negative regulation of cell killing (GO:0031342)3.75948877
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.75948877
21neutrophil activation (GO:0042119)3.75506843
22cellular extravasation (GO:0045123)3.69341048
23immunoglobulin mediated immune response (GO:0016064)3.68265972
24B cell receptor signaling pathway (GO:0050853)3.59935637
25negative regulation of T cell mediated immunity (GO:0002710)3.59504079
26modulation by symbiont of host immune response (GO:0052553)3.58459458
27positive regulation by symbiont of host defense response (GO:0052509)3.58459458
28modulation by symbiont of host defense response (GO:0052031)3.58459458
29modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.58459458
30modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.58459458
31positive regulation by organism of defense response of other organism involved in symbiotic interact3.58459458
32cell wall macromolecule catabolic process (GO:0016998)3.52588235
33positive regulation of leukocyte degranulation (GO:0043302)3.48553495
34antigen processing and presentation of endogenous antigen (GO:0019883)3.47213573
35antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.45777385
36positive regulation of granulocyte differentiation (GO:0030854)3.45579842
37response to muramyl dipeptide (GO:0032495)3.39288366
38granulocyte activation (GO:0036230)3.38809215
39detection of other organism (GO:0098543)3.38802234
40positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.36371168
41negative regulation of erythrocyte differentiation (GO:0045647)3.29896890
42negative regulation of interleukin-12 production (GO:0032695)3.27986746
43myeloid leukocyte mediated immunity (GO:0002444)3.25535034
44negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.25249642
45myeloid cell activation involved in immune response (GO:0002275)3.24427627
46purinergic nucleotide receptor signaling pathway (GO:0035590)3.19723377
47detection of bacterium (GO:0016045)3.17019220
48regulation of regulated secretory pathway (GO:1903305)3.17005498
49mast cell activation (GO:0045576)3.15667950
50microglial cell activation (GO:0001774)3.15333440
51positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.14795223
52defense response to protozoan (GO:0042832)3.14560087
53positive thymic T cell selection (GO:0045059)3.12974586
54response to protozoan (GO:0001562)3.10390312
55positive regulation of B cell differentiation (GO:0045579)3.08939141
56macrophage activation involved in immune response (GO:0002281)3.08781007
57negative regulation of lymphocyte mediated immunity (GO:0002707)3.08142419
58positive regulation of interleukin-17 production (GO:0032740)3.05695743
59interferon-gamma production (GO:0032609)3.05602670
60negative regulation of granulocyte differentiation (GO:0030853)3.01220738
61positive regulation of regulated secretory pathway (GO:1903307)3.00388658
62regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.99668551
63regulation of B cell differentiation (GO:0045577)2.96861798
64regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.96664039
65negative T cell selection (GO:0043383)2.92364447
66regulation of alpha-beta T cell proliferation (GO:0046640)2.92340555
67positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.92268529
68regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.92196098
69negative thymic T cell selection (GO:0045060)2.91459337
70germinal center formation (GO:0002467)2.90587303
71cellular response to exogenous dsRNA (GO:0071360)2.90013287
72cell wall macromolecule metabolic process (GO:0044036)2.88778321
73positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.87112157
74regulation of granulocyte differentiation (GO:0030852)2.86983390
75respiratory burst (GO:0045730)2.86466228
76mature B cell differentiation involved in immune response (GO:0002313)2.85073291
77definitive hemopoiesis (GO:0060216)2.84952486
78negative regulation of interleukin-6 production (GO:0032715)2.83564188
79positive regulation of alpha-beta T cell proliferation (GO:0046641)2.81760450
80L-fucose catabolic process (GO:0042355)2.81694691
81fucose catabolic process (GO:0019317)2.81694691
82L-fucose metabolic process (GO:0042354)2.81694691
83negative regulation of leukocyte mediated immunity (GO:0002704)2.80552323
84leukocyte degranulation (GO:0043299)2.79747861
85thrombin receptor signaling pathway (GO:0070493)2.78794757
86positive regulation of antigen processing and presentation (GO:0002579)2.77980292
87regulation of interleukin-6 biosynthetic process (GO:0045408)2.77045616
88Arp2/3 complex-mediated actin nucleation (GO:0034314)2.76513766
89leukocyte aggregation (GO:0070486)2.75767190
90regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.75242593
91negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.74170574
92antigen processing and presentation via MHC class Ib (GO:0002475)2.74146283
93regulation of interleukin-8 biosynthetic process (GO:0045414)2.73700370
94positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.72933824
95positive regulation of immunoglobulin mediated immune response (GO:0002891)2.72789302
96positive regulation of B cell mediated immunity (GO:0002714)2.72789302
97antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.71400199
98NIK/NF-kappaB signaling (GO:0038061)2.70939789
99B cell mediated immunity (GO:0019724)2.70399693
100regulation of T cell mediated cytotoxicity (GO:0001914)2.70102630

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.71407976
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.63101622
3SCL_19346495_ChIP-Seq_HPC-7_Human3.56608001
4VDR_21846776_ChIP-Seq_THP-1_Human3.18261518
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.15549184
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.11463935
7VDR_24763502_ChIP-Seq_THP-1_Human3.02900155
8IRF8_27001747_Chip-Seq_BMDM_Mouse2.64414698
9RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.59925268
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.58567808
11MYB_26560356_Chip-Seq_TH2_Human2.55184819
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.49395202
13RUNX_20019798_ChIP-Seq_JUKART_Human2.47907644
14SPI1_23547873_ChIP-Seq_NB4_Human2.45271109
15E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.35721363
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.31343497
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.26771210
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.22827850
19LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.14821941
20VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.13772554
21MAF_26560356_Chip-Seq_TH1_Human2.07702009
22UTX_26944678_Chip-Seq_JUKART_Human2.07415062
23MYB_26560356_Chip-Seq_TH1_Human2.00771813
24STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.00240764
25RUNX1_22412390_ChIP-Seq_EML_Mouse2.00062904
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.99035825
27MYB_21317192_ChIP-Seq_ERMYB_Mouse1.93561557
28MYC_22102868_ChIP-Seq_BL_Human1.91728338
29VDR_24787735_ChIP-Seq_THP-1_Human1.88774978
30SPI1_23127762_ChIP-Seq_K562_Human1.86898246
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.81004810
32LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.79925203
33MAF_26560356_Chip-Seq_TH2_Human1.78596518
34GATA3_26560356_Chip-Seq_TH2_Human1.78060269
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.72079189
36MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.70549069
37GATA3_27048872_Chip-Seq_THYMUS_Human1.65906627
38STAT4_19710469_ChIP-ChIP_TH1__Mouse1.65737024
39FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.65272513
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.63577152
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.60367049
42GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.54117969
43BCL6_27268052_Chip-Seq_Bcells_Human1.53281211
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52219708
45BCOR_27268052_Chip-Seq_Bcells_Human1.50214544
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48137310
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.44830816
48TCF7_22412390_ChIP-Seq_EML_Mouse1.42743521
49SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.42585125
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.41097418
51GATA1_19941826_ChIP-Seq_K562_Human1.39386849
52SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.37415834
53PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.34354383
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.33905404
55EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.33405336
56RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.31575800
57KDM2B_26808549_Chip-Seq_SUP-B15_Human1.29298246
58GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27979517
59KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.25265566
60CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24063952
61P300_27268052_Chip-Seq_Bcells_Human1.22146912
62E2F1_20622854_ChIP-Seq_HELA_Human1.21205418
63P68_20966046_ChIP-Seq_HELA_Human1.19879175
64GATA1_19941827_ChIP-Seq_MEL_Mouse1.19663829
65PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19129740
66CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18951961
67CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18725912
68KDM2B_26808549_Chip-Seq_DND41_Human1.17416559
69VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.17399450
70Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.17179331
71CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16577110
72PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16312713
73TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14937393
74GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14846489
75CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.13570828
76PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12216431
77GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11987546
78ELF1_20517297_ChIP-Seq_JURKAT_Human1.11293858
79ERA_21632823_ChIP-Seq_H3396_Human1.10909476
80RAC3_21632823_ChIP-Seq_H3396_Human1.09369259
81SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09344404
82RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.09195771
83CIITA_25753668_ChIP-Seq_RAJI_Human1.08805907
84PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08803803
85RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.06855155
86SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06819765
87TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05198698
88RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04902838
89SPI1_20517297_ChIP-Seq_HL60_Human1.04479806
90FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04114248
91KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03944896
92PHF8_20622854_ChIP-Seq_HELA_Human1.03573902
93CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01100618
94CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00752856
95STAT1_20625510_ChIP-Seq_HELA_Human0.99729415
96CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98772150
97IKZF1_21737484_ChIP-ChIP_HCT116_Human0.98512241
98SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97702455
99CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.96672167
100NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96440615

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.86719866
2MP0003724_increased_susceptibility_to3.32089623
3MP0003436_decreased_susceptibility_to3.19519717
4MP0005671_abnormal_response_to2.97585795
5MP0001800_abnormal_humoral_immune2.91719114
6MP0002419_abnormal_innate_immunity2.88777573
7MP0000685_abnormal_immune_system2.86823697
8MP0002148_abnormal_hypersensitivity_rea2.74133764
9MP0005025_abnormal_response_to2.62480590
10MP0002452_abnormal_antigen_presenting2.58233719
11MP0005387_immune_system_phenotype2.55511470
12MP0001790_abnormal_immune_system2.55511470
13MP0005000_abnormal_immune_tolerance2.54138051
14MP0002723_abnormal_immune_serum2.53595107
15MP0002420_abnormal_adaptive_immunity2.46379166
16MP0003303_peritoneal_inflammation2.44002482
17MP0001819_abnormal_immune_cell2.42943887
18MP0009278_abnormal_bone_marrow2.42748655
19MP0005464_abnormal_platelet_physiology2.35441805
20MP0003172_abnormal_lysosome_physiology2.32328493
21MP0001986_abnormal_taste_sensitivity2.31427575
22MP0009785_altered_susceptibility_to2.29072502
23MP0003763_abnormal_thymus_physiology2.21569245
24MP0006082_CNS_inflammation2.13390621
25MP0002396_abnormal_hematopoietic_system2.10842188
26MP0009764_decreased_sensitivity_to2.04094814
27MP0002398_abnormal_bone_marrow1.93652970
28MP0000716_abnormal_immune_system1.89073780
29MP0002009_preneoplasia1.87141567
30MP0001545_abnormal_hematopoietic_system1.86713316
31MP0005397_hematopoietic_system_phenotyp1.86713316
32MP0000465_gastrointestinal_hemorrhage1.71539019
33MP0010155_abnormal_intestine_physiology1.67497852
34MP0000689_abnormal_spleen_morphology1.63322139
35MP0001845_abnormal_inflammatory_respons1.63197278
36MP0002405_respiratory_system_inflammati1.59008938
37MP0001533_abnormal_skeleton_physiology1.58504615
38MP0005174_abnormal_tail_pigmentation1.57883200
39MP0004947_skin_inflammation1.56665057
40MP0004381_abnormal_hair_follicle1.54351354
41MP0002722_abnormal_immune_system1.52057769
42MP0002429_abnormal_blood_cell1.50631426
43MP0002166_altered_tumor_susceptibility1.46907978
44MP0005058_abnormal_lysosome_morphology1.39582362
45MP0009333_abnormal_splenocyte_physiolog1.38595285
46MP0003828_pulmonary_edema1.36647131
47MP0008469_abnormal_protein_level1.36350590
48MP0000015_abnormal_ear_pigmentation1.32486574
49MP0004883_abnormal_blood_vessel1.31818854
50MP0003866_abnormal_defecation1.31633739
51MP0003646_muscle_fatigue1.30982739
52MP0000703_abnormal_thymus_morphology1.21877868
53MP0001853_heart_inflammation1.15730152
54MP0002933_joint_inflammation1.13380443
55MP0001873_stomach_inflammation1.13318388
56MP0008260_abnormal_autophagy1.11816720
57MP0002132_abnormal_respiratory_system1.10907258
58MP0002998_abnormal_bone_remodeling1.09270204
59MP0000858_altered_metastatic_potential1.09170923
60MP0004808_abnormal_hematopoietic_stem1.07017935
61MP0003656_abnormal_erythrocyte_physiolo1.04406430
62MP0001501_abnormal_sleep_pattern1.01180023
63MP0002006_tumorigenesis1.00003527
64MP0005075_abnormal_melanosome_morpholog0.99316575
65MP0005310_abnormal_salivary_gland0.97630785
66MP0008961_abnormal_basal_metabolism0.96539415
67MP0002928_abnormal_bile_duct0.94486382
68MP0000569_abnormal_digit_pigmentation0.93785191
69MP0005084_abnormal_gallbladder_morpholo0.93547454
70MP0004130_abnormal_muscle_cell0.92030337
71MP0003252_abnormal_bile_duct0.89111733
72MP0005164_abnormal_response_to0.87984641
73MP0005083_abnormal_biliary_tract0.87478096
74MP0005390_skeleton_phenotype0.86160734
75MP0000249_abnormal_blood_vessel0.84499788
76MP0000681_abnormal_thyroid_gland0.79079062
77MP0000343_altered_response_to0.77668131
78MP0005166_decreased_susceptibility_to0.77003146
79MP0003075_altered_response_to0.70227014
80MP0002095_abnormal_skin_pigmentation0.69629100
81MP0009840_abnormal_foam_cell0.69325218
82MP0003300_gastrointestinal_ulcer0.67396680
83MP0001663_abnormal_digestive_system0.67378894
84MP0000470_abnormal_stomach_morphology0.65657026
85MP0001851_eye_inflammation0.65363603
86MP0003191_abnormal_cellular_cholesterol0.64515052
87MP0008004_abnormal_stomach_pH0.63833171
88MP0008057_abnormal_DNA_replication0.62749245
89MP0005376_homeostasis/metabolism_phenot0.62347448
90MP0009763_increased_sensitivity_to0.61241081
91MP0008995_early_reproductive_senescence0.61188813
92MP0002876_abnormal_thyroid_physiology0.59794711
93MP0002277_abnormal_respiratory_mucosa0.59785758
94MP0005410_abnormal_fertilization0.59505178
95MP0003959_abnormal_lean_body0.59116511
96MP0003183_abnormal_peptide_metabolism0.58732622
97MP0000230_abnormal_systemic_arterial0.58149805
98MP0005535_abnormal_body_temperature0.57296453
99MP0002693_abnormal_pancreas_physiology0.57121802
100MP0003195_calcinosis0.56324364

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)5.49309760
2Stomatitis (HP:0010280)4.71266504
3Myositis (HP:0100614)4.68283361
4Recurrent abscess formation (HP:0002722)4.50376779
5Recurrent bacterial skin infections (HP:0005406)4.48574078
6Eczematoid dermatitis (HP:0000976)3.96446189
7Recurrent fungal infections (HP:0002841)3.86609112
8Retrobulbar optic neuritis (HP:0100654)3.77291873
9Optic neuritis (HP:0100653)3.77291873
10Abnormality of macrophages (HP:0004311)3.70702031
11Prolonged bleeding time (HP:0003010)3.69424176
12Orchitis (HP:0100796)3.68982875
13Congenital stationary night blindness (HP:0007642)3.64694178
14Chronic mucocutaneous candidiasis (HP:0002728)3.43020730
15Recurrent cutaneous fungal infections (HP:0011370)3.43020730
16Autoimmune thrombocytopenia (HP:0001973)3.40813295
17Abnormal delayed hypersensitivity skin test (HP:0002963)3.39267429
18Increased neuronal autofluorescent lipopigment (HP:0002074)3.34695206
19Meningitis (HP:0001287)3.30623228
20Amyloidosis (HP:0011034)3.29642172
21Recurrent gram-negative bacterial infections (HP:0005420)3.25354930
22Increased cerebral lipofuscin (HP:0011813)3.23125397
23Stomach cancer (HP:0012126)3.18769509
24Recurrent skin infections (HP:0001581)3.12854603
25Encephalitis (HP:0002383)3.12556939
26Spontaneous hematomas (HP:0007420)3.06223902
27Increased serum ferritin (HP:0003281)2.99372111
28Vasculitis (HP:0002633)2.97548970
29Increased IgE level (HP:0003212)2.96786493
30Mediastinal lymphadenopathy (HP:0100721)2.96033848
31Chronic obstructive pulmonary disease (HP:0006510)2.91747119
32Obstructive lung disease (HP:0006536)2.91747119
33Agammaglobulinemia (HP:0004432)2.91010266
34Petechiae (HP:0000967)2.87984615
35Panhypogammaglobulinemia (HP:0003139)2.84084573
36Acute lymphatic leukemia (HP:0006721)2.81864312
37Keratoconjunctivitis sicca (HP:0001097)2.76837379
38Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.76738047
39Epistaxis (HP:0000421)2.76036177
40Recurrent viral infections (HP:0004429)2.76003015
41Attenuation of retinal blood vessels (HP:0007843)2.75961872
42Leukocytosis (HP:0001974)2.73261609
43Inflammation of the large intestine (HP:0002037)2.72897452
44Keratoconjunctivitis (HP:0001096)2.72712037
45Hemoptysis (HP:0002105)2.70609622
46Abnormality of T cell physiology (HP:0011840)2.69251804
47Absent rod-and cone-mediated responses on ERG (HP:0007688)2.69139705
48Abnormality of T cells (HP:0002843)2.66891054
49Abnormality of iron homeostasis (HP:0011031)2.62894635
50Abnormality of B cell number (HP:0010975)2.62582558
51Abnormal rod and cone electroretinograms (HP:0008323)2.60797109
52Gastrointestinal inflammation (HP:0004386)2.56281500
53Abnormality of liposaccharide metabolism (HP:0010968)2.51979853
54Abnormality of glycosphingolipid metabolism (HP:0004343)2.51979853
55Abnormality of glycolipid metabolism (HP:0010969)2.51979853
56Pulmonary infiltrates (HP:0002113)2.47269341
57Abnormality of T cell number (HP:0011839)2.47034922
58Clumsiness (HP:0002312)2.45073215
59Urticaria (HP:0001025)2.43742672
60Prostate neoplasm (HP:0100787)2.43414185
61Cellulitis (HP:0100658)2.43340198
62Gastrointestinal infarctions (HP:0005244)2.42565872
63Granulocytopenia (HP:0001913)2.39274786
64Abnormality of transition element cation homeostasis (HP:0011030)2.37116392
65Episodic fever (HP:0001954)2.35511562
66T lymphocytopenia (HP:0005403)2.34527921
67Autoimmune hemolytic anemia (HP:0001890)2.30541102
68Pustule (HP:0200039)2.29856744
69Purpura (HP:0000979)2.28324302
70Abnormality of the prostate (HP:0008775)2.28231748
71Increased IgM level (HP:0003496)2.28209939
72Chest pain (HP:0100749)2.23708855
73Colitis (HP:0002583)2.22423105
74Hypochromic anemia (HP:0001931)2.20238196
75Eosinophilia (HP:0001880)2.17632164
76Gingival bleeding (HP:0000225)2.11444887
77Genetic anticipation (HP:0003743)2.11410765
78Thrombocytosis (HP:0001894)2.11147685
79Abnormality of the pleura (HP:0002103)2.09222128
80Constricted visual fields (HP:0001133)2.04870948
81IgG deficiency (HP:0004315)2.03994205
82Facial diplegia (HP:0001349)2.01635400
83Skin rash (HP:0000988)2.01053384
84Osteomyelitis (HP:0002754)1.99833256
85Pulmonary embolism (HP:0002204)1.99319462
86Macular degeneration (HP:0000608)1.97107882
87Arterial thrombosis (HP:0004420)1.96320621
88Vacuolated lymphocytes (HP:0001922)1.91812109
89Anorexia (HP:0002039)1.91674938
90Abnormality of eosinophils (HP:0001879)1.90738641
91Chronic diarrhea (HP:0002028)1.88950669
92Chronic sinusitis (HP:0011109)1.87828890
93Cheilitis (HP:0100825)1.86705947
94Decreased central vision (HP:0007663)1.86148067
95Protruding tongue (HP:0010808)1.85089662
96Abolished electroretinogram (ERG) (HP:0000550)1.84615485
97Amelogenesis imperfecta (HP:0000705)1.84601795
98Dysostosis multiplex (HP:0000943)1.84431969
99Impaired platelet aggregation (HP:0003540)1.83576314
100Abnormal platelet function (HP:0011869)1.83576314

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.96377718
2TESK23.78850081
3MAP4K13.30161344
4TXK2.82736674
5TAOK32.73582065
6BLK2.68519557
7FES2.46476080
8BTK2.31866948
9GRK62.26034386
10MAPK152.25404583
11ZAP702.19430060
12TEC2.19039651
13IRAK42.08329492
14SYK2.03344079
15KIT2.01482326
16MAP3K141.88127952
17TYK21.83526487
18ITK1.82523483
19BMPR21.78884754
20TNK21.77602078
21IKBKB1.69619195
22MAP3K111.64642367
23HCK1.61848201
24IKBKE1.60751570
25CSF1R1.60293719
26TBK11.59077822
27MAP2K21.56073593
28ADRBK21.54057168
29TRPM71.49393804
30FRK1.43790111
31LYN1.36861270
32CSK1.31671637
33GRK11.29118539
34MAP2K31.24359449
35CDK191.23557594
36ERN11.20299055
37JAK31.17752019
38LCK1.15242547
39TLK11.09190701
40MAPK71.07777120
41MAP3K61.06007726
42KDR1.05499311
43MARK31.02289536
44IRAK10.98321509
45ACVR1B0.96830064
46MATK0.95283846
47HIPK20.95027540
48MAP3K10.94252176
49PIK3CG0.88235099
50JAK20.81241338
51MAP3K130.81030981
52DAPK20.79969119
53ZAK0.77701575
54RPS6KA60.77591204
55CHUK0.76473716
56FLT30.73621357
57GRK70.68303100
58MAP4K20.67827532
59PRKD20.67675280
60JAK10.66898686
61WNK40.65983297
62PRKCQ0.64951619
63PIM10.63756290
64MAP2K60.62794601
65ADRBK10.59330796
66MOS0.58717767
67RPS6KL10.58317348
68RPS6KC10.58317348
69CAMKK20.56411885
70PRPF4B0.56299061
71SIK30.54373531
72MARK20.54273545
73CAMK1D0.52564282
74PDPK10.51771203
75IRAK20.51555814
76FGR0.50754851
77PDK10.50521432
78ABL10.50020870
79MAPK120.49647274
80SIK20.49082220
81MAPKAPK30.49053126
82DYRK1B0.47604860
83MAPK40.47311619
84CDK60.44957453
85CDK120.44438841
86CAMKK10.43901245
87MAP3K50.42953230
88MAPKAPK20.40088695
89MUSK0.39393977
90MAPK30.38498785
91OXSR10.38478970
92IRAK30.36480176
93TRIB30.35953691
94RPS6KA40.35795259
95RPS6KA50.31732335
96MAP3K70.31670019
97DYRK30.30849019
98CAMK40.30375189
99PTK2B0.28741462
100PRKD10.27719268

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.05949622
2Intestinal immune network for IgA production_Homo sapiens_hsa046722.86097765
3Leishmaniasis_Homo sapiens_hsa051402.68752407
4Primary immunodeficiency_Homo sapiens_hsa053402.40419562
5Graft-versus-host disease_Homo sapiens_hsa053322.36532013
6Allograft rejection_Homo sapiens_hsa053302.34260980
7Osteoclast differentiation_Homo sapiens_hsa043802.33174923
8NOD-like receptor signaling pathway_Homo sapiens_hsa046212.32212159
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.29394903
10Autoimmune thyroid disease_Homo sapiens_hsa053202.20626552
11Staphylococcus aureus infection_Homo sapiens_hsa051502.12234600
12Other glycan degradation_Homo sapiens_hsa005111.99145181
13B cell receptor signaling pathway_Homo sapiens_hsa046621.96291651
14Hematopoietic cell lineage_Homo sapiens_hsa046401.92801279
15Tuberculosis_Homo sapiens_hsa051521.88458830
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.73664712
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.71628269
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.70398102
19Type I diabetes mellitus_Homo sapiens_hsa049401.66735007
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.66254286
21Malaria_Homo sapiens_hsa051441.64285983
22Legionellosis_Homo sapiens_hsa051341.61040325
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.58484131
24T cell receptor signaling pathway_Homo sapiens_hsa046601.56475842
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.53723266
26Rheumatoid arthritis_Homo sapiens_hsa053231.51827873
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.45059127
28Regulation of autophagy_Homo sapiens_hsa041401.42590300
29Platelet activation_Homo sapiens_hsa046111.38988117
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.38095742
31Antigen processing and presentation_Homo sapiens_hsa046121.37386282
32Influenza A_Homo sapiens_hsa051641.30916419
33Phototransduction_Homo sapiens_hsa047441.29841832
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.24880467
35Toxoplasmosis_Homo sapiens_hsa051451.22860152
36TNF signaling pathway_Homo sapiens_hsa046681.22675820
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.21197562
38Acute myeloid leukemia_Homo sapiens_hsa052211.19918661
39Herpes simplex infection_Homo sapiens_hsa051681.19074417
40Dorso-ventral axis formation_Homo sapiens_hsa043201.16671649
41Viral myocarditis_Homo sapiens_hsa054161.15319866
42Jak-STAT signaling pathway_Homo sapiens_hsa046301.15107073
43Lysosome_Homo sapiens_hsa041421.11831334
44Pertussis_Homo sapiens_hsa051331.09969263
45Chemokine signaling pathway_Homo sapiens_hsa040621.07762589
46African trypanosomiasis_Homo sapiens_hsa051431.07619045
47Linoleic acid metabolism_Homo sapiens_hsa005911.04350815
48Pancreatic secretion_Homo sapiens_hsa049721.03990238
49Glycosaminoglycan degradation_Homo sapiens_hsa005311.01649263
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.01522378
51Measles_Homo sapiens_hsa051620.96634117
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96298452
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.89123053
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.87635576
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83190902
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.81071469
57Hepatitis B_Homo sapiens_hsa051610.79804536
58Arachidonic acid metabolism_Homo sapiens_hsa005900.79581441
59Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76538784
60ABC transporters_Homo sapiens_hsa020100.73678567
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72866366
62Phagosome_Homo sapiens_hsa041450.70591700
63Salmonella infection_Homo sapiens_hsa051320.69299032
64Nitrogen metabolism_Homo sapiens_hsa009100.67973726
65Ether lipid metabolism_Homo sapiens_hsa005650.67657451
66Shigellosis_Homo sapiens_hsa051310.67099733
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66578064
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65250696
69Glycerolipid metabolism_Homo sapiens_hsa005610.62299655
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.59123824
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58443460
72Apoptosis_Homo sapiens_hsa042100.57529631
73Morphine addiction_Homo sapiens_hsa050320.52166301
74MAPK signaling pathway_Homo sapiens_hsa040100.48597738
75Olfactory transduction_Homo sapiens_hsa047400.47234153
76GnRH signaling pathway_Homo sapiens_hsa049120.46288008
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45088189
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.43453492
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.41708949
80Calcium signaling pathway_Homo sapiens_hsa040200.41461823
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40640350
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40165212
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.39645029
84Collecting duct acid secretion_Homo sapiens_hsa049660.38327508
85Epstein-Barr virus infection_Homo sapiens_hsa051690.38193263
86Sulfur relay system_Homo sapiens_hsa041220.37666487
87Leukocyte transendothelial migration_Homo sapiens_hsa046700.37426851
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37314183
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.35772794
90Salivary secretion_Homo sapiens_hsa049700.35253539
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.34719320
92HTLV-I infection_Homo sapiens_hsa051660.34614386
93Ovarian steroidogenesis_Homo sapiens_hsa049130.33279769
94VEGF signaling pathway_Homo sapiens_hsa043700.32992348
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32787529
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30609166
97Endocytosis_Homo sapiens_hsa041440.28990160
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28926610
99Histidine metabolism_Homo sapiens_hsa003400.28684451
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.26420941

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